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1. Pan-Asian adaptation of the EHNS–ESMO–ESTRO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with squamous cell carcinoma of the head and neck

Author

Keam, B., Machiels, J.-P., Kim, H.R., Licitra, L., Golusinski, W., Gregoire, V., Lee, Y.G., Belka, C., Guo, Y., Rajappa, S.J., Tahara, M., Azrif, M., Ang, M.K., Yang, M.-H., Wang, C.-H., Ng, Q.S., Wan Zamaniah, W.I., Kiyota, N., Babu, S., Yang, K., Curigliano, G., Peters, S., Kim, T.W., Yoshino, T., and Pentheroudakis, G.

Published
2021
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7. 706TiP Phase III study assessing the “best of” radiotherapy compared to the “best of” surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0-N1 oropharyngeal, supraglottic carcinoma and with T1, N0 hypopharyngeal carcinoma

Author

Simon, C., primary, Fortpied Lefevre, C., additional, Govaerts, A-S., additional, Raveloarivahy, T., additional, Bourhis, J., additional, Evans, M., additional, Klussmann, J.P., additional, Leemans, C.R., additional, Hunter, K.D., additional, Singer, S., additional, Nuyts, S., additional, Willemse, E., additional, Ansarin, M., additional, Spriano, G., additional, Golusinski, W., additional, Giger, R., additional, Boehm, A., additional, Lopez, F., additional, and Grégoire, V., additional

Published
2022
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9. A European survey on the practice of nutritional interventions in head-neck cancer patients undergoing curative treatment with radio(chemo)therapy

Author

Bozzetti, F., Gurizzan, C., Lal, S., Gossum, A. van, Wanten, G.J.A., Golusinski, W., Hosal, S., Bossi, P., Bozzetti, F., Gurizzan, C., Lal, S., Gossum, A. van, Wanten, G.J.A., Golusinski, W., Hosal, S., and Bossi, P.

Abstract

Item does not contain fulltext, PURPOSE: As the practice of nutritional support in patients with head and neck cancer (HNC) during curative radio(chemo)therapy is quite heterogeneous, we carried out a survey among European specialists. METHODS: A 19-item questionnaire was drawn up and disseminated via the web by European scientific societies involved in HNC and nutrition. RESULTS: Among 220 responses, the first choice was always for the enteral route; naso-enteral tube feeding was preferred to gastrostomy in the short term, while the opposite for period longer than 1 month. Indications were not solely related to the patient's nutritional status, but also to the potential burden of the therapy. CONCLUSION: European HNC specialists contextualize the use of the nutritional support in a comprehensive plan of therapy. There is still uncertainty relating to the role of naso-enteral feeding versus gastrostomy feeding in patients requiring < 1 month nutritional support, an issue that should be further investigated.

Published
2022

10. Phase III study assessing the best of radiotherapy compared to the best of surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0-N1 oropharyngeal, supraglottic carcinoma and with T1, N0 hypopharyngeal carcinoma

Author

Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., Gregoire, V., Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., and Gregoire, V.

Published
2022

12. Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients

Author

Tjon Pian Gi, R. E. A., Ilmarinen, T., van den Heuvel, E. R., Aaltonen, L. M., Andersen, J., Brunings, J. W., Chirila, M., Dietz, A., Ferran Vilà, F., Friedrich, G., de Gier, H. H. W., Golusinski, W., Graupp, M., Hantzakos, A., Horcasitas, R., Jackowska, J., Koelmel, J. C., Lawson, G., Lindner, F., Remacle, M., Sittel, C., Weichbold, V., Wierzbicka, M., and Dikkers, F. G.

Published
2013
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13. The impact of Allergic Rhinitis in clinical practice: An International Survey

Author

Passali, D, Passali, G, Damiani, V, Passali, F, Cingi, C, Di Girolamo, S, Ciprandi, G, International Study Group on Allergic Rhinitis: Agius, A, Ahluwalia, H, Al Abri, A, Alho, O, Bachert, C, Balaji, N, Balsevicius, T, Baudoin, T, Benghalem, A, Bhattarai, H, Boci, B, Bunnang, C, Carvajal, J, Charalambous, M, Chen, L, Cuilty Siller, C, Dimov, P, Din, M, Douglas, R, Durham, S, Eloy, P, Erdenechuluun, B, Felippu Neto, A, Fliss, D, Gendeh, S, Gerlinger, I, Golusinski, W, Hadi, U, Hasbellaoui, M, Heinichen, J, Huizing, E, Jenko, K, Kamel, R, Kawauchi, H, Kennedy, D, Kern, E, Kiesling Calderon, V, Kopacheva Barsova, G, Landis, B, Lopatin, A, Lubbe, D, Marakyna-Kibak, L, Matuba, K, Melendez, A, Mesbahi, A, Metsmaa, M, Mladina, R, Mosges, R, Nassir, T, Negm, H, Nguyen Thi ND, Nyembue, D, Onerci, T, Pais Clemente, M, Papavassiliou, A, Patil, N, Perdomo Flores EA, Plzak, J, Rahman, H, Rhee, C, Rodriguez, H, Sacks, R, Salaverry, F, Sandul, A, Sarafoleanu, C, Sarandeses Garcia, A, Shukuryan, A, Sicak, M, Siguror, K, Silva Chacon, F, Stankovic, M, Stierna, L, Stott, C, Tariq Rafi SM, Talishinskiy, A, Tarafder, K, Tong, M, Tulebayev, R, Vicente, G, Von Buchwald, C, Wagener, M, Wang, D, Wardani, R, Yeh, T, and Zabolotnyi, D

Subjects
Settore MED/31
Published
2021

14. The hidden curve behind COVID-19 outbreak: the impact of delay in treatment initiation in cancer patients and how to mitigate the additional risk of dying—the head and neck cancer model

Author

Matos, L.L. Forster, C.H.Q. Marta, G.N. Castro Junior, G. Ridge, J.A. Hirata, D. Miranda-Filho, A. Hosny, A. Sanabria, A. Gregoire, V. Patel, S.G. Fagan, J.J. D’Cruz, A.K. Licitra, L. Mehanna, H. Hao, S.-P. Psyrri, A. Porceddu, S. Galloway, T.J. Golusinski, W. Lee, N.Y. Shiguemori, E.H. Matieli, J.E. Shiguemori, A.P.A.C. Diamantino, L.R. Schiaveto, L.F. Leão, L. Castro, A.F. Carvalho, A.L. Kowalski, L.P.

Abstract

Purpose: The rapid spread of the SARS-CoV-2 pandemic around the world caused most healthcare services to turn substantial attention to treatment of these patients and also to alter the structure of healthcare systems to address an infectious disease. As a result, many cancer patients had their treatment deferred during the pandemic, increasing the time-to-treatment initiation, the number of untreated patients (which will alter the dynamics of healthcare delivery in the post-pandemic era) and increasing their risk of death. Hence, we analyzed the impact on global cancer mortality considering the decline in oncology care during the COVID-19 outbreak using head and neck cancer, a known time-dependent disease, as a model. Methods: An online practical tool capable of predicting the risk of cancer patients dying due to the COVID-19 outbreak and also useful for mitigation strategies after the peak of the pandemic has been developed, based on a mathematical model. The scenarios were estimated by information of 15 oncological services worldwide, given a perspective from the five continents and also some simulations were conducted at world demographic data. Results: The model demonstrates that the more that cancer care was maintained during the outbreak and also the more it is increased during the mitigation period, the shorter will be the recovery, lessening the additional risk of dying due to time-to-treatment initiation. Conclusions: This impact of COVID-19 pandemic on cancer patients is inevitable, but it is possible to minimize it with an effort measured by the proposed model. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Published
2021

15. Pan-Asian adaptation of the EHNS–ESMO–ESTRO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with squamous cell carcinoma of the head and neck

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre du cancer, Keam, B., Machiels, J.-P., Kim, H.R., Licitra, L., Golusinski, W., Gregoire, V., Lee, Y.G., Belka, C., Guo, Y., Rajappa, S.J., Tahara, M., Azrif, M., Ang, M.K., Yang, M.-H., Wang, C.-H., Ng, Q.S., Wan Zamaniah, W.I., Kiyota, N., Babu, S., Yang, K., Curigliano, G., Peters, S., Kim, T.W., Yoshino, T., Pentheroudakis, G., UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre du cancer, Keam, B., Machiels, J.-P., Kim, H.R., Licitra, L., Golusinski, W., Gregoire, V., Lee, Y.G., Belka, C., Guo, Y., Rajappa, S.J., Tahara, M., Azrif, M., Ang, M.K., Yang, M.-H., Wang, C.-H., Ng, Q.S., Wan Zamaniah, W.I., Kiyota, N., Babu, S., Yang, K., Curigliano, G., Peters, S., Kim, T.W., Yoshino, T., and Pentheroudakis, G.

Abstract

The most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of squamous cell carcinoma (SCC) of the oral cavity, larynx, oropharynx and hypopharynx was published in 2020. It was therefore decided by both the ESMO and the Korean Society of Medical Oncology (KSMO) to convene a special, virtual guidelines meeting in July 2021 to adapt the ESMO 2020 guidelines to consider the potential ethnic differences associated with the treatment of SCCs of the head and neck (SCCHN) in Asian patients. These guidelines represent the consensus opinions reached by experts in the treatment of patients with SCCHN (excluding nasopharyngeal carcinomas) representing the oncological societies of Korea (KSMO), China (CSCO), India (ISMPO), Japan (JSMO), Malaysia (MOS), Singapore (SSO) and Taiwan (TOS). The voting was based on scientific evidence and was independent of the current treatment practices and drug access restrictions in the different Asian countries. The latter was discussed when appropriate. This manuscript provides a series of expert recommendations (Clinical Practice Guidelines) which can be used to provide guidance to health care providers and clinicians for the optimisation of the diagnosis, treatment and management of patients with SCC of the oral cavity, larynx, oropharynx and hypopharynx across Asia.

Published
2021

16. Reprint of 'Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up'.

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Service d'oto-rhino-laryngologie, Machiels, Jean-Pascal, René Leemans, C, Golusinski, W, Grau, C, Licitra, L, Gregoire, V, EHNS Executive Board, ESMO Guidelines Committee, ESTRO Executive Board, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Service d'oto-rhino-laryngologie, Machiels, Jean-Pascal, René Leemans, C, Golusinski, W, Grau, C, Licitra, L, Gregoire, V, and EHNS Executive Board, ESMO Guidelines Committee, ESTRO Executive Board

Abstract

This EHNS-ESMO-ESTRO Clinical Practice Guideline provides key recommendations for managing SCCHN. It covers clinical and pathological diagnosis, staging and risk assessment, treatment and follow-up. Opportunities for personalised medicine in SCCHN are also discussed. All recommendations were compiled by a multidisciplinary group of experts from different institutions and countries. Recommendations are based on available clinical evidence and the collective expert opinion of the authors.

Published
2021

18. An International Survey on the pragmatic management of epistaxis

Author

Passali, D, Damiani, V, Passali, Fm, Tosca, Ma, Motta, G, Ciprandi, G, Agius, A, Ahluwalia, H, Al Abri, A, Alho, Op, Bachert, C, Balaji, N, Balsevicius, T, Baudoin, T, Benghalem, A, Bhattarai, H, Boci, B, Bunnang, C, Carvajal, Jd, Charalambous, M, Chen, L, Cuilty Siller, C, Dimov, P, Din, Mf, Douglas, Rg, Durham, Sr, Eloy, P, Erdenechuluun, B, Felippu Neto, A, Fliss, Dm, Gendeh, S, Gerlinger, I, Golusinski, W, Hadi, U, Hasbellaoui, M, Heinichen, J, Huizing, Eh, Jenko, K, Kamel, R, Kawauchi, H, Kennedy, D, Kern, E, Kiesling Calderon, V, Kopacheva Barsova, G, Landis, Bn, Lopatin, A, Lubbe, D, Marakyna-Kibak, L, Matuba, Kmd, Melendez, A, Mesbahi, A, Metsmaa, M, Mladina, R, Mosges, R, Nassir, Th, Negm, Hma, Nguyen Thi, Nd, Nyembue, Dt, Onerci, Tm, Pais Clemente, M, Papavassiliou, Ag, Patil, Np, Perdomo Flores, Ea, Plzak, J, Rahman, Ha, Rhee, Cs, Rodriguez, Ha, Sacks, R, Salaverry, F, Sandul, A, Sarafoleanu, Cc, Sarandeses Garcia, A, Shukuryan, Ak, Sicak, M, Siguror, K, Silva Chacon, F, Stankovic, M, Stierna, Lep, Stott, C, Tariq Rafi, Sm, Talishinskiy, A, Tarafder, Kh, Tong, M, Tulebayev, Rk, Vicente, Gm, Von Buchwald, C, Wagener, M, Wang, Dy, Wardani, Rs, Yeh, Th, Zabolotnyi, D, Passali, Desiderio, Damiani, Valerio, Passali, Francesco Maria, Tosca, Maria Angela, Motta, Gaetano, and Ciprandi, Giorgio

Subjects
Adult, Male, Adolescent, epistaxis, emergency, otorhinolaryngology, Infant, Middle Aged, Global Health, surgery, Young Adult, Child, Preschool, Health Care Surveys, Settore MED/31, Humans, Original Article, Female, medical treatment, Preschool, Child
Abstract

Epistaxis is one of the most common ear, nose and throat emergencies. The management of epistaxis has evolved significantly in recent years, including the use of nasal cautery and packs. However, a correct treatment requires the knowledge of nasal anatomy, potential risks, and complications of treatment. Epistaxis is often a simple and readily treatable condition, even though a significant bleed may have potentially severe consequences. At present, there are very few guidelines concerning this topic. The current Survey explored the pragmatic approach in managing epistaxis. A questionnaire, including 7 practical questions has been used. The current International Survey on epistaxis management reported a relevant prevalence (21.7%), mainly during childhood and senescence, an important hospitalization rate (11.8%), the common use of anterior packing and electrocoagulation, and the popular prescription of a vitamin supplement and intranasal creams. (www.actabiomedica.it)

Published
2020

19. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Author

UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, Machiels, J-P, René Leemans, C, Golusinski, W, Grau, C, Licitra, L, Gregoire, V, EHNS Executive Board. Electronic address: secretariat@ehns.org, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org, ESTRO Executive Board. Electronic address: info@estro.org, UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, Machiels, J-P, René Leemans, C, Golusinski, W, Grau, C, Licitra, L, Gregoire, V, EHNS Executive Board. Electronic address: secretariat@ehns.org, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org, and ESTRO Executive Board. Electronic address: info@estro.org

Abstract

No abstract available

Published
2020

20. Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus

Author

Mehanna, H, Hardman, JC, Shenson, JA, Abou-Foul, AK, Topf, MC, AlFalasi, M, Chan, JYK, Chaturvedi, P, Chow, VLY, Dietz, A, Fagan, JJ, Godballe, C, Golusinski, W, Homma, A, Hosal, S, Iyer, NG, Kerawala, C, Koh, YW, Konney, A, Kowalski, LP, Kraus, D, Kuriakose, MA, Kyrodimos, E, Lai, SY, Leemans, CR, Lennon, P, Licitra, L, Lou, P-J, Lyons, B, Mirghani, H, Nichols, AC, Paleri, V, Panizza, BJ, Arias, PP, Patel, MR, Piazza, C, Rischin, D, Sanabria, A, Takes, RP, Thomson, DJ, Uppaluri, R, Wang, Y, Yom, SS, Zhu, Y-M, Porceddu, SV, De Almeida, JR, Simon, C, Holsinger, FC, Mehanna, H, Hardman, JC, Shenson, JA, Abou-Foul, AK, Topf, MC, AlFalasi, M, Chan, JYK, Chaturvedi, P, Chow, VLY, Dietz, A, Fagan, JJ, Godballe, C, Golusinski, W, Homma, A, Hosal, S, Iyer, NG, Kerawala, C, Koh, YW, Konney, A, Kowalski, LP, Kraus, D, Kuriakose, MA, Kyrodimos, E, Lai, SY, Leemans, CR, Lennon, P, Licitra, L, Lou, P-J, Lyons, B, Mirghani, H, Nichols, AC, Paleri, V, Panizza, BJ, Arias, PP, Patel, MR, Piazza, C, Rischin, D, Sanabria, A, Takes, RP, Thomson, DJ, Uppaluri, R, Wang, Y, Yom, SS, Zhu, Y-M, Porceddu, SV, De Almeida, JR, Simon, C, and Holsinger, FC

Abstract

The speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is an urgent need to identify consensus statements on head and neck surgical oncology practice. We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. Endorsed by 39 societies and professional bodies, these consensus practice recommendations aim to decrease inconsistency of practice, reduce uncertainty in care, and provide reassurance for clinicians worldwide for head and neck surgical oncology in the context of the COVID-19 pandemic and in the setting of acute severe resource constraint and high risk of infection to patients and staff.

Published
2020

25. Age of onset of recurrent respiratory papillomatosis: a distribution analysis

Author

San Giorgi, M.R.M., primary, van den Heuvel, E.R., additional, Tjon Pian Gi, R.E.A., additional, Brunings, J.W., additional, Chirila, M., additional, Friedrich, G., additional, Golusinski, W., additional, Graupp, M., additional, Horcasitas Pous, R.A., additional, Ilmarinen, T., additional, Jackowska, J., additional, Koelmel, J.C., additional, Ferran Vilà, F., additional, Weichbold, V., additional, Wierzbicka, M., additional, and Dikkers, F.G., additional

Published
2016
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26. Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: An international retrospective study on 635 RRP patients

Author

Tjon Pian Gi, R.E.A. Ilmarinen, T. Van Den Heuvel, E.R. Aaltonen, L.M. Andersen, J. Brunings, J.W. Chirila, M. Dietz, A. Ferran Vilà, F. Friedrich, G. De Gier, H.H.W. Golusinski, W. Graupp, M. Hantzakos, A. Horcasitas, R. Jackowska, J. Koelmel, J.C. Lawson, G. Lindner, F. Remacle, M. Sittel, C. Weichbold, V. Wierzbicka, M. Dikkers, F.G.

Subjects
animal diseases, viruses, virus diseases, respiratory system
Abstract

Intralesional use of cidofovir (Vistide®) has been one of the mainstays of adjuvant therapy in patients with recurrent respiratory papillomatosis (RRP) since 1998. In 2011, a communication provided by the producer of cidofovir addressed very serious side effects concerning its off-label use. As this was a general warning, it was inconclusive whether this would account for its use in RRP. The aim of this study is to determine whether nephrotoxic, neutropenic, or oncogenic side effects have occurred after intralesional use of cidofovir in patients with RRP. Update of recent developments in RRP, a multicentre questionnaire and a multicentre retrospective chart review. Sixteen hospitals from eleven countries worldwide submitted records of 635 RRP patients, of whom 275 were treated with cidofovir. RRP patients received a median of three intralesional injections (interquartile range 2-6). There were no statistical differences in occurrence of neutropenia or renal dysfunction before and after cidofovir. There was no statistical difference in occurrence of upper airway and tracheal malignancies between the cidofovir and the non-cidofovir group. In this retrospective patient chart review, no clinical evidence was found for more long-term nephrotoxicity, neutropenia or laryngeal malignancies after the administration of intralesional cidofovir in RRP patients. © 2013 Springer-Verlag Berlin Heidelberg.

Published
2013

30. Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients.

Author

UCL - (MGD) Service d'oto-rhino-laryngologie, Tjon Pian Gi, R E A, Ilmarinen, T, van den Heuvel, E R, Aaltonen, L M, Andersen, J, Brunings, J W, Chirila, M, Dietz, A, Ferran Vilà, F, Friedrich, G, de Gier, H H W, Golusinski, W, Graupp, M, Hantzakos, A, Horcasitas, R, Jackowska, J, Koelmel, J C, Lawson, Georges, Lindner, F, Remacle, Marc, Sittel, C, Weichbold, V, Wierzbicka, M, Dikkers, F G, UCL - (MGD) Service d'oto-rhino-laryngologie, Tjon Pian Gi, R E A, Ilmarinen, T, van den Heuvel, E R, Aaltonen, L M, Andersen, J, Brunings, J W, Chirila, M, Dietz, A, Ferran Vilà, F, Friedrich, G, de Gier, H H W, Golusinski, W, Graupp, M, Hantzakos, A, Horcasitas, R, Jackowska, J, Koelmel, J C, Lawson, Georges, Lindner, F, Remacle, Marc, Sittel, C, Weichbold, V, Wierzbicka, M, and Dikkers, F G

Abstract

Intralesional use of cidofovir (Vistide(®)) has been one of the mainstays of adjuvant therapy in patients with recurrent respiratory papillomatosis (RRP) since 1998. In 2011, a communication provided by the producer of cidofovir addressed very serious side effects concerning its off-label use. As this was a general warning, it was inconclusive whether this would account for its use in RRP. The aim of this study is to determine whether nephrotoxic, neutropenic, or oncogenic side effects have occurred after intralesional use of cidofovir in patients with RRP. Update of recent developments in RRP, a multicentre questionnaire and a multicentre retrospective chart review. Sixteen hospitals from eleven countries worldwide submitted records of 635 RRP patients, of whom 275 were treated with cidofovir. RRP patients received a median of three intralesional injections (interquartile range 2-6). There were no statistical differences in occurrence of neutropenia or renal dysfunction before and after cidofovir. There was no statistical difference in occurrence of upper airway and tracheal malignancies between the cidofovir and the non-cidofovir group. In this retrospective patient chart review, no clinical evidence was found for more long-term nephrotoxicity, neutropenia or laryngeal malignancies after the administration of intralesional cidofovir in RRP patients.

Published
2013

31. Treatment of recurrent respiratory papillomatosis and adverse reactions following off-label use of cidofovir (Vistide®)

Author

UCL - (MGD) Service d'oto-rhino-laryngologie, Tjon Pian Gi, R.E.A., Dietz, A., Djukic, V., Eckel, H.E., Friedrich, G., Golusinski, W., Hantzakos, A., Lawson, Georges, Remacle, Marc, Rihkanen, H., Dikkers, F.G., UCL - (MGD) Service d'oto-rhino-laryngologie, Tjon Pian Gi, R.E.A., Dietz, A., Djukic, V., Eckel, H.E., Friedrich, G., Golusinski, W., Hantzakos, A., Lawson, Georges, Remacle, Marc, Rihkanen, H., and Dikkers, F.G.

Published
2012

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