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13 results on '"Gomes, Lia Lima"'

1. Characterization of Mycobacterium tuberculosis var. africanum isolated from a patient with pulmonary tuberculosis in Brazil

Author

Rabahi, Marcelo Fouad, Conceição, Emilyn Costa, de Paiva, Luísa Oliveira, Souto, Marcos Vinícius Muniz Lemes, Sisco, Maria Carolina, de Waard, Jacobus, de Souza Caldas, Paulo Cesar, Fandinho, Fatima, Ramos, Jesus Pais, de Carvalho, Luciana Distasio, Campos, Carlos Eduardo Dias, Lima, Karla Valéria Batista, da Silva, Sandro Patroca, Sharma, Abhinav, Robledo, Jaime, Paez, Uriel Alonso Hurtado, Duarte, Rafael Silva, da Silva, Marlei Gomes, Gomes, Lia Lima, Vasconcellos, Sidra Ezidio Gonçalves, Uwezeye, Cecile, de Jong, Bouke C., Junqueira-Kipnis, Ana Paula, and Suffys, Philip Noel

Published
2020
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2. Genetic Characterization and Population Structure of Drug-Resistant Mycobacterium tuberculosis Isolated from Brazilian Patients Using Whole-Genome Sequencing

Author

Esteves, Leonardo Souza, primary, Gomes, Lia Lima, additional, Brites, Daniela, additional, Fandinho, Fátima Cristina Onofre, additional, Bhering, Marcela, additional, Pereira, Márcia Aparecida da Silva, additional, Conceição, Emilyn Costa, additional, Salvato, Richard, additional, Costa, Bianca Porphirio da, additional, Medeiros, Reginalda Ferreira de Melo, additional, Caldas, Paulo Cesar de Souza, additional, Redner, Paulo, additional, Dalcolmo, Margareth Pretti, additional, Eldholm, Vegard, additional, Gagneux, Sebastien, additional, Rossetti, Maria Lucia, additional, Kritski, Afrânio Lineu, additional, and Suffys, Philip Noel, additional

Published
2024
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3. Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells

Author

Gomes, Lia Lima, Vasconcellos, Sidra Ezidrio Gonçalves, Gomes, Harrison Magdinier, Elias, Atina Ribeiro, da Silva Rocha, Adalgiza, Ribeiro, Simone C.M., Panunto, Alessandra Costa, Ferrazoli, Lucilaine, da Silva Telles, Maria Alice, Ivens de, Araujo Marelo Emanuel, Kritski, Afranio Lineu, Mokrousov, Igor, Manicheva, Olga A., Lasunskaia, Elena, and Suffys, Philip Noel

Published
2015
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4. Whole genome sequence of Mycobacterium kansasii isolates of the genotype 1 from Brazilian patients with pulmonary disease demonstrates considerable heterogeneity

Author

Machado, Edson, primary, Vasconcellos, Sidra Ezidio Gonçalves, additional, Cerdeira, Camillo, additional, Gomes, Lia Lima, additional, Junqueira, Ricardo, additional, Carvalho, Luciana Distasio de, additional, Ramos, Jesus Pais, additional, Redner, Paulo, additional, Campos, Carlos Eduardo Dias, additional, Caldas, Paulo Cesar de Souza, additional, Gomes, Ana Paula Chaves Sobral, additional, Goldenberg, Telma, additional, Montes, Fatima Fandinho, additional, Mello, Fernanda Carvalho de Queiroz, additional, Mussi, Vinicius de Oliveira, additional, Lasunskaia, Elena, additional, Soolingen, Dick van, additional, Miranda, Antonio Basílio de, additional, Rigouts, Leen, additional, Jong, Bouke C de, additional, Meehan, Conor J, additional, Catanho, Marcos, additional, and Suffys, Philip N, additional

Published
2018
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5. Rapid Assay for Detection of the Epidemiologically Important Central Asian/Russian Strain of the Mycobacterium tuberculosis Beijing Genotype

Author

Mokrousov, Igor, primary, Chernyaeva, Ekaterina, additional, Vyazovaya, Anna, additional, Skiba, Yuriy, additional, Solovieva, Natalia, additional, Valcheva, Violeta, additional, Levina, Klavdia, additional, Malakhova, Natalya, additional, Jiao, Wei-Wei, additional, Gomes, Lia Lima, additional, Suffys, Philip N., additional, Kütt, Marge, additional, Aitkhozhina, Nagima, additional, Shen, A-Dong, additional, Narvskaya, Olga, additional, and Zhuravlev, Viacheslav, additional

Published
2018
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7. Strain Classification of Mycobacterium tuberculosis Isolates in Brazil Based on Genotypes Obtained by Spoligotyping, Mycobacterial Interspersed Repetitive Unit Typing and the Presence of Large Sequence and Single Nucleotide Polymorphism

Author

Vasconcellos, Sidra E. G., primary, Acosta, Chyntia Carolina, additional, Gomes, Lia Lima, additional, Conceição, Emilyn Costa, additional, Lima, Karla Valéria, additional, de Araujo, Marcelo Ivens, additional, Leite, Maria de Lourdes, additional, Tannure, Flávio, additional, Caldas, Paulo Cesar de Souza, additional, Gomes, Harrison M., additional, Santos, Adalberto Rezende, additional, Gomgnimbou, Michel K., additional, Sola, Christophe, additional, Couvin, David, additional, Rastogi, Nalin, additional, Boechat, Neio, additional, and Suffys, Philip Noel, additional

Published
2014
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8. Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage

Author

Ribeiro, Simone C. M., primary, Gomes, Lia Lima, additional, Amaral, Eduardo P., additional, Andrade, Marcelle R. M., additional, Almeida, Fabricio M., additional, Rezende, Andreza L., additional, Lanes, Verônica R., additional, Carvalho, Eulógio C. Q., additional, Suffys, Philip N., additional, Mokrousov, Igor, additional, and Lasunskaia, Elena B., additional

Published
2014
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10. Emerging multidrug resistant Mycobacterium tuberculosis strains of the Beijing genotype circulating in Russia express a pattern of biological properties associated with enhanced virulence

Author

Lasunskaia, Elena, primary, Ribeiro, Simone C.M., additional, Manicheva, Olga, additional, Gomes, Lia Lima, additional, Suffys, Philip N., additional, Mokrousov, Igor, additional, Ferrazoli, Lucilaine, additional, Andrade, Marcelle R.M., additional, Kritski, Afranio, additional, Otten, Tatiana, additional, Kipnis, Thereza L., additional, da Silva, Wilmar D., additional, Vishnevsky, Boris, additional, Oliveira, Martha M., additional, Gomes, Harrison M., additional, Baptista, Ida F., additional, and Narvskaya, Olga, additional

Published
2010
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11. Mycobacterium tuberculosisStrains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage

Author

Ribeiro, Simone C. M., Gomes, Lia Lima, Amaral, Eduardo P., Andrade, Marcelle R. M., Almeida, Fabricio M., Rezende, Andreza L., Lanes, Verônica R., Carvalho, Eulógio C. Q., Suffys, Philip N., Mokrousov, Igor, and Lasunskaia, Elena B.

Abstract

ABSTRACTStrains of the Beijing genotype family of Mycobacterium tuberculosisare a cause of particular concern because of their increasing dissemination in the world and their association with drug resistance. Phylogenetically, this family includes distinct ancient and modern sublineages. The modern strains, contrary to the ancestral counterparts, demonstrated increasing prevalence in many world regions that suggest an enhanced bacterial pathogenicity. We therefore evaluated virulence of modern versus ancient Beijing strains with similar epidemiological and genotype characteristics. For this, we selected six strains that had very similar 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing profiles and belonged to the region of difference 181 (RD181) subgroup but differed using markers (mutT2and mutT4genes and NTF locus) that discriminate between modern and ancient Beijing sublineages. The strains were isolated from native patients in Brazil and Mozambique, countries with a low prevalence of Beijing strains. The virulence levels of these strains were determined in models of pulmonary infection in mice and in vitromacrophage infection and compared with that of a strain from Russia, part of the epidemic and hypervirulent Beijing clone B0/W148, and of the laboratory strain H37Rv. The results showed that two of the three modern Beijing strains were highly pathogenic, exhibiting levels of virulence comparable with that of the epidemic Russian strain. In contrast, all isolates of the ancient sublineage displayed intermediate or low virulence. The data obtained demonstrate that the strains of the modern Beijing sublineage are more likely to exhibit highly virulent phenotypes than ancient strains and suggest that genetic alterations characteristic of the modern Beijing sublineage favor selection of highly virulent bacteria.

Published
2014
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12. Russian “Successful” Clone B0/W148 of Mycobacterium tuberculosisBeijing Genotype: a Multiplex PCR Assay for Rapid Detection and Global Screening

Author

Mokrousov, Igor, Narvskaya, Olga, Vyazovaya, Anna, Otten, Tatiana, Jiao, Wei-Wei, Gomes, Lia Lima, Suffys, Philip N., Shen, A-Dong, and Vishnevsky, Boris

Abstract

ABSTRACTWe describe a multiplex PCR assay to detect the Mycobacterium tuberculosisBeijing genotype variant B0/W148, which is considered a “successful” clone of M. tuberculosis, widespread in Russia. Specificity and sensitivity of the assay were 100% based on the analysis of a collection of 516 M. tuberculosisisolates of different genotypes and origins. This assay may be used for accurate and simple detection and surveillance of this clinically and epidemiologically important variant of M. tuberculosis.

Published
2012
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