15 results on '"Gomes-Pereira L"'
Search Results
2. Runoff and erosion at the micro-plot and slope scale in a small burnt catchment, central Portugal
- Author
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Vieira, D., Keizer, J., Nunes, J., Fernandes I., Faria, S., Ferreira, R., Pedrosa, E., Varela, M., and Gomes Pereira, L.
- Subjects
burnt catchment ,runoff ,erosion - Abstract
Wildfires can have important impacts on hydrological processes and soil erosion in forest catchments, due to the destruction of vegetation cover and changes to soil properties. However, the processes involved are non-linear and not fully understood. This has severely limited the understanding on the impacts of wildfires, especially in the up-scaling from hillslopes to catchments; in consequence, current models are poorly adapted for burnt forest conditions. The objective of this presentation is to give an overview of the hydrological response and sediment yield from the micro-plot to slope scale, in the first year following a wildfire (2008/2009) that burnt an entire catchment nearby the Colmeal village, central Portugal. The overview will focus on three slopes inside the catchment, with samples including: • Runoff at micro-plot scale (12 bounded plots) and slope scale (12 open plots); • Sediments and Organic Matter loss at micro-plot scale (12 bounded plots) and slope scale (12 open plots plus 3 Sediment fences); • Rainfall and Soil moisture data; • Soil Water Repellency and Ground Cover data. The analysis of the first year following the wildfire clearly shows the complexity of runoff generation and the associated sediment transport in recently burnt areas, with pronounced differences between hillslopes and across spatial scales as well as with marked variations through time. This work was performed in the framework of the EROSFIRE-II project (PTDC/AGR-CFL/70968/2006) which has as overall aim to predict soil erosion risk in recently burnt forest areas, including common post-fire forest management practices; the project focuses on the simultaneous measurement of runoff and soil erosion at multiple spatial scales.The results to be presented in this session are expected to show how sediment is generated, transported and exported in the Colmeal watershed; and contribute to understand and simulate erosion processes in burnt catchments, including for model development and evaluation.
- Published
- 2011
3. The study of soil, hydrological, erosion and vegetation processes following wildfire in the Colmeal study area, central Portugal
- Author
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Keizer, J., Nunes, J., Sande Silva, J., Gomes Pereira, L., Vieira, D., Varela, M., Prats, S., Pinheiro, J., Pereira, V., Mendes, H., Malvar, M., Maia, P., Ferreira, R., Faria, S., Coelho, C., Albuquerque, A., Abrantes, N., Benali, A., Santos, A., Magalhães, M., Ferreira, A., Fernandes, I., and Cambra, S
- Subjects
Erosion processes ,Soil processes ,Wildfire ,Hydrological processes ,Vegetation processes - Abstract
The EROSFIRE-II project (PTDC/AGR-CFL/70968/2006) has as overall aim to predict soil erosion risk in recently burnt forest areas, including following common post-fire forest management practices. Although the project’s main focus is on onsite erosion processes, also the export of sediments out of small catchments is addressed. To this end, a study area of about 60 ha located near to the village of Colmeal (municipality of Góis, central Portugal) was instrumented extensively following a wildfire during August 2008, and has been monitored intensively afterwards.(...)
- Published
- 2010
4. Runoff and erosion in a small burnt catchment in central Portugal
- Author
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Vieira, D., Keizer, J., Nunes, J., Fernandes, I., Faria, S., Ferreira, R., Varela, M., and Gomes Pereira, L.
- Abstract
Post-fire erosion is a major concern because of its potential effects on soil and water resources. Wildfire is frequently observed to increases soil erosion rates (Shakesby and Doerr, 2006). Many studies have emphasized the role of the partial or entire elimination of vegetation and ground cover (thereby exposing the mineral soil to direct impact of raindrops and overland flow) as a key factor in the increased soil losses. Also fire-induced changes in topsoil properties like total porosity (e.g. Neary et al., 2005) and water repellency (e.g. Keizer et al., 2008a) can enhance overland flow and the associated transport of soil particles. Existing process-based erosion models like e.g. WEPP (Nearing et al., 1989) and EUROSEM (Morgan et al., 1998) can successfully simulate the effect of vegetation on soil losses in individual storms but their complexity often limits their usefulness for non-academic purposes. Therefore, empirical models such as USLE (Wischmeier and Smith, 1978) continue to be widely used. For example, the Portuguese national Water Institute (INAG) applied USLE to the 300.000 ha of rural areas affected by wildfires during the summer of 2003. However, the model’s suitability for burnt areas (as opposed to the agricultural areas for which USLE was originally developed) was not supported by field observations. The present work concerns the EROSFIRE-II project (PTDC/AGR-CFL/70968/2006), which has as overall aim to assess the suitability of selected models for predicting soil erosion in recently burnt forest areas in Portugal. The proposed presentation will focus on the evaluation of the revised Morgan-Morgan-Finney model (MMF; Morgan, 2001) against slope-scale measurements of overland flow and/or erosion during the first year after fire. Earlier studies reported this model to perform satisfactorily in forests and shrublands in the humid areas of the north-eastern Iberian Peninsula (Keizer et al., 2008b; Fernández et al., 2010). The hydrological and erosion response at the catchment scale will be modeled with MEFIDIS (Nunes et al., 2005) but that is beyond the present scope.
- Published
- 2010
5. 3D segmentation of forest structure using an adaptive mean shift based procedure
- Author
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Ferraz, A., Bretar, F., Jacquemoud, S., Gonçalves, G., and Gomes Pereira, L.
- Subjects
Multi-layered forest ,3-D mapping ,LiDAR ,Airborne laser scanning ,mean-shift algorithm - Abstract
Plant communities display a vertical structure based on the size and growth pattern of the dominant species. To a large extent, this pattern, called vertical stratification, depends on the climatic zone. Vertical structure analysis consists in detecting the number of layers and their limits within a forest stand. So far, there is a lack of robust approaches applied to airborne laser scanning (ALS) data that properly segment the different strata of forests having complex structures. In this study, we propose a procedure to characterize vertical forest stratification based on the mean shift (MS) algorithm. The MS is a non-linear filter that searches for local density maxima (modes). It is a non-parametric and unsupervised approach, which only requires a single criterion, the kernel bandwidth. Since the forest point cloud is a multi-modal distribution, the MS is used to find the modes which are supposed to be the barycenters of vegetation features. Once achieved, the modes are grouped together according to height range and the corresponding ALS points are assigned to each vegetation strata. Due to their complex pattern, using a single scale over the whole space is not recommended for the analysis of such environments. On this basis, the modes are computed using a variable kernel bandwidth according to the forest pattern. To depict such a pattern, we propose a new technique that segments the main forest layers at the plot level: overstory, understory, and surface vegetation. The procedure has been carried out on 45 plots of a Portuguese forest mainly composed of eucalyptus (Eucalyptus globulus) and pine (Pinus pinaster) trees that can be strongly populated by understory and surface vegetation.
- Published
- 2010
6. Integration of Aerial Laser Scanning Data and CIR Images to Produce DTM in Urban Areas: Preliminary Results
- Author
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Gonçalves, G. and Gomes Pereira, L.
- Subjects
DTM ,Integration ,Urban areas ,Laser scanning ,CIR images - Abstract
Airborne Laser Scanning is an established technique to produce Digital Terrain Models (DTM). In spite of its widespread use, the extraction of a DTM in urban areas still poses problems because the filtering process often fails to separate some of the objects on the terrain surface from the terrain itself. This happens because only one kind of information – geometric information – is used in the process. To overcome this problem a methodology is proposed that integrates aerial laser scanning data with high-resolution orto-rectified CIR images to extract reliable information of the terrain and of the objects on it (like buildings and trees). The methodology was tested in an urban area located in north Portugal. The obtained results show that in complex urban areas the proposed methodology has a superior performance than the conventional one.
- Published
- 2010
7. Effect of the Resolution and Accuracy of DTM produced with Aerial Photogrammetry and Terrestrial Laser Scanning on Slope- and Catchment-scale Erosion Assessment in a Recently Burnt Forest Area: a Case Study
- Author
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Cambra, S., Gomes Pereira, L., and Keizer, J.
- Subjects
Terrestrial laser scanning ,Burnt forest ,Erosion assessment ,Aerial photogrammetry ,DTM accuracy ,DTM resolution - Abstract
Wildfires are a common phenomenon in Portugal, affecting on average 100.000 ha of rural areas per year and up to 400.000 ha in dramatic years like 2003 and 2005. Wildfires can strongly enhance the hydrological response and associated sediment losses in recently burnt forest catchments and, thereby, negatively affect land-use sustain- ability of the affected terrains as well as ecosystem functioning of downstream aquatic habitats. Therefore, the EROSFIRE-I and –II projects aim at developing a GIS-tool for predicting soil erosion hazard following wildfire and, ultimately, for assessing the implications of alternative post-fire land management practices. Assessment of runoff and soil erosion rates critically depends on accurate estimates of the corresponding runoff areas. In the case of catchments as well as unbounded erosion plots (arguably, the only practical solution for slope-scale measurements), delineation of runoff area requires a Digital Terrain Model (DTM) with an adequate resolution and accuracy. The DTM that was available for the Colmeal study area, localized in the mountain range of Lousã, in the central part of Portugal, of EROSFIRE-II project is that of the 1:25.000 topographic map produced by the Military Geographic Institute. Since the Colmeal area involves a rather small experimental catchment of roughly 10 ha and relatively short study slopes of less than 100 m long, two different data acquisition techniques were used to produce high-resolution and high-accuracy DTM. One of the data acquisition techniques is aerial photogrammetry whilst the other is terrestrial laser scanning. In order to produce a DTM by photogrammetric means, a dedicated digital aerial photography mission was carried out. The images have a pixel size of 10 cm. Manual measurements permitted to measure breaklines and were complemented by automatic measurements. In this way, a DTM in a TIN format was produced. This was further converted to grid format using the ArcGIS software system. Signalized control points allowed obtaining the DTM in the same global reference system as that employed for terrestrial laser scanning. The terrestrial laser scanning was done using a Riegl LMS Z360I, stationed in 8 points within the area to provide a complete coverage. The resulting dense cloud of points was filtered – by the company carrying out the scanning mission - to remove the non-terrain points (in particular vegetation). Several grids of different sizes were produced (0.10 x 0.10, 0.20 x 0.20, 0.50 x 0.50, 1 x 1 and 2 x 2 m2). This work will study the effect on runoff and erosion rates at the slope- and catchment-scale of DTM with differ- ent resolution, but produced with data collected with the same acquisition technique, and of DTM with the same resolution, but produced with data collected with the two different acquisition techniques. The study is being carried out in ArcGIS using DTM in a grid format. Preliminary results suggest that the conver- sion of TIN-to-grid in ArcGIS produces results that depend on the procedure being applied. Therefore, the different algorithms available at ArcGIS for TIN-to-grid conversion are currently being tested, using an artificially produced DTM. This testing includes various interpolation techniques for grid generation, and will be extended to different algorithms for computation of drainage flow direction.
- Published
- 2010
8. Hydrological and erosion response at micro-plot to -catchment scale following forest wildfire, north-central Portugal
- Author
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Vieira, D., Keizer, J., Nunes, J., Fernandes, I., Ferreira, R., Gomes Pereira, L., Prats, S., Rial, M., and Varela, M.
- Subjects
micro-plot scale ,hydrological response ,erosion response ,Wildfires ,catchment scale - Abstract
Wildfires can have important impacts on hydrological and soil erosion processes, due to the destruction of vegetation cover and changes to soil properties. According to Shakesby and Doerr (2006), these wildfire effects are: i) much better known at small spatial scales (especially erosion plots) than at the scale of catchments; ii) much better studied with respect to overland flow and streamflow (and, then, especially peak discharges) than to soil erosion. Following up on a precursor project studying runoff generation and the associated soil losses from micro-plot to slope-scale in Portuguese eucalypt forests, the EROSFIRE-II project addresses the connectivity of these processes across hillslopes as well as within the channel network. This is done in the Colmeal study area in central Portugal, where the outlet of an entirely burnt catchment of roughly 10 ha was instrumented with a gauging station continuously recording water level and tubidity, and five slopes were each equipped with 4 runoff plots of < 0,5 m2 (“micro-plot”) and 4 slope-scale plots as well as 1 slope-scale sediment fence. Starting one month after the August 2008 wildfire, the plots were monitored at 1- to 2-weekly intervals, depending on the occurrence of rainfall. The gauging station became operational at the end of November 2008, since the in-situ construction of an H-flume required several weeks. A preliminary analysis of the data collected till the end of 2008, focusing on two slopes with contrasting slope lengths as well as the gauging station: revealed clear differences in runoff and erosion between: (i) the micro-plot and slope-scale plots on the same hillslope; (ii) the two slopes; (iii) an initial dry period and a subsequent much wetter period; (iv) the slopes and the catchment-scale, also depending on the sampling period. These results suggest that the different processes govern the hydrological and erosion response at different spatial scales as well as for different periods, with soil water repellency playing a role during the initial post-fire period. The current presentation will review these preliminary results based on the data collected during the first year after the wildfire.
- Published
- 2010
9. Accuracy of a DTM derived from full-waveform laser scanning data under unstructured eucalypt forest: a case study
- Author
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Gomes Pereira, L. and Gonçalves, G.
- Subjects
DTM ,Full-waveform laser scanning ,Vertical accuracy ,Unstructured Eucalypti forest - Abstract
A Digital Terrain Model (DTM) is fundamental for extracting several forest canopy structure metrics from data acquired with small-footprint airborne laser scanning (ALS). This modern remote sensing technology is based on laser measurements from a laser system mounted on an aircraft and integrated with a geodetic GNSS receiver and an inertial measurement unit (IMU) or inertia navigation system (INS). In the context of a research project for deriving forest inventory parameters and fuel variables under eucalypt stands in Mediterranean climates, the vertical precision of the DTM obtained by automatic filtering of full-waveform ALS data had to be evaluated. The DTM accuracy estimation on a study area with peculiar characteristics, which are often avoided in related studies, will also allow verifying the performance of full- waveform ALS systems. The accuracy estimation is carried out in a novel way. By novel way, it is meant an exhaustive, well-planned collection of reliable control data in forest environment. The collection of the control data involves the production of DTM on 43 circular plots (radius = 11.28m) using total stations and geodetic GNSS receivers. These DTM, with a total of 3356 points, allowed one to evaluate consistently and reliably the vertical accuracy of the terrain surface produced with ALS under a eucalypt forest. This global accuracy, expressed by the Root Mean Square Error (RMSE) of the vertical differences between the field surveyed surface and the ALS derived DTM surface is 0.15m (mean=0.08m and std=0.09m). This impressive value indicates that, for an ALS point cloud density of 10pts/m2 and footprint of 20 cm, the methodology used to extract the DTM from full- waveform ALS data under an unstructured eucalypt forest is very accurate. In this article it is addressed both the strategy adopted to collect the control data and the quality assessment of the DTM produced by means of the ALS data.
- Published
- 2010
10. Assessment of the performance of eight filtering algorithms by using full-waveform LiDAR data of unmanaged eucalypt forest
- Author
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Gonçalves, G. and Gomes Pereira, L.
- Subjects
Unmanaged eucalypt forest ,LiDAR ,Filtering algorithms - Abstract
In this study the strengths and weaknesses of eight filtering algorithms are evaluated by using the mean, standard deviation and RMSE metrics. Seven of these algorithms are implemented in the freeware software ALDPAT (Airborne LiDAR Data Processing and Analysis Tools) and the eighth, known as the Axelsson filter, in the commercial software Terrascan. The referred metrics are calculated by using DTM of topographic surfaces with quite different morphologies and vegetation covers. Forty-three of these surfaces, on circular plots of 400 m2 each, are covered by brushwood and unmanaged eucalypt forest with different stand characteristics. The mean tree density is around 1600 trees per hectare. The reference DTM for assessing the DTM produced by filtering full-waveform LiDAR data using the eight filtering algorithms are created with the help of a total station and geodetic GNSS receivers. The results show that the Axelsson and the so-called Polynomial Two Surface Fitting filters give the best results in terms of RMSE. Nonetheless, the results also show that all the tested filters are suitable for the filtering of full-waveform LiDAR data used in forestry related work, and collected over areas with great amount and high brushwood, chaotic eucalypt tree distribution and high tree density. The results obtained for a forest area with such characteristics – among which it should be mentioned a RMSE of 15 cm - are quite surprising.
- Published
- 2010
11. Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery-a scoping review.
- Author
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Alves Bersot CD, Ferreira Gomes Pereira L, Goncho VGV, Pereira JEG, and Falcão LFDR
- Abstract
Introduction: The relationship between the Enhanced Recovery After Surgery (ERAS) guidelines and inflammatory markers in laparoscopic surgery has garnered increasing attention. These recommendations are designed to minimize surgical stress and potentially improve recovery outcomes by modifying perioperative care., Objective: This scoping review aims to evaluate the impact of ERAS recommendations on inflammatory markers in patients undergoing laparoscopic surgeries, identifying current research gaps and consolidating findings from existing studies., Methods: Guided by the Cochrane Handbook for Systematic Reviews and adhering to the PRISMA-ScR guidelines, this review analyzed studies from databases like PubMed, Scopus, and Cochrane Library. We included both randomized controlled trials and observational studies that assessed inflammatory markers such as C-reactive protein (CRP), white blood cells (WBC), and Interleukin-6 (IL-6) in laparoscopic surgery patients managed with ERAS recommendations., Results: Out of 64 initial studies, 7 met the inclusion criteria, involving a total of 2,047 patients. Most of the studies focused on laparoscopic colorectal surgeries. Commonly assessed markers were CRP and WBC. The findings consistently showed that ERAS guideline could mitigate the inflammatory response, evidenced by reduced levels of CRP and IL-6, which correlated with fewer postoperative complications and expedited recovery., Conclusion: ERAS recommendations appear to beneficially modulate inflammatory responses in laparoscopic surgery, which suggests a potential for enhanced recovery outcomes. However, the evidence is currently limited by the small number of studies and inherent methodological biases. Further robust RCTs are required to strengthen the evidence base and refine these protocols for broader clinical application., Systematic Review Registration: https://osf.io/tj8mw/., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Alves Bersot, Ferreira Gomes Pereira, Goncho, Pereira and Falcão.)
- Published
- 2024
- Full Text
- View/download PDF
12. Pharmacokinetics, biodistribution, and in vivo toxicity of 7-nitroindazole loaded in pegylated and non-pegylated nanoemulsions in rats.
- Author
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França AP, Silva TA, Schulz D, Gomes-Pereira L, Cunha LMA, Gonçalves MP, Vieira JVS, Sanches MP, Koehler N, Maluf S, Poli A, da Silva-Santos JE, Assreuy J, and Lemos-Senna E
- Subjects
- Rats, Animals, Rats, Wistar, Tissue Distribution, Indazoles toxicity, Indazoles pharmacokinetics, Polyethylene Glycols toxicity, Enzyme Inhibitors pharmacology, Nitric Oxide Synthase metabolism, Sepsis
- Abstract
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. The development of sepsis is associated with excessive nitric oxide (NO) production, which plays an important role in controlling vascular homeostasis. 7-nitroindazole (7-NI) is a selective inhibitor of neuronal nitric oxide synthase (NOS-1) with potential application for treating NO imbalance conditions. However, 7-NI exhibits a low aqueous solubility and a short plasma half-life. To circumvent these biopharmaceutical limitations, pegylated (NEPEG
7NI ) and non-pegylated nanoemulsions (NENPEG7 NI ) containing 7-NI were developed. This study evaluates the pharmacokinetic profiles and toxicological properties of 7-NI loaded into the nanoemulsions. After a single intravenous administration of the free drug and the nanoemulsions at a dose of 10 mg.kg-1 in Wistar rats, 7-NI was widely distributed in the organs. The pharmacokinetic parameters of Cmax , t1/2 , and AUC0-t were significantly increased after administration of the NEPEG7NI , compared to both free 7-NI and NENPEG7NI (p < 0.05). No observable adverse effects were observed after administering the free 7-NI, NEPEG7NI , or NENPEG7NI in the animals after a single dose of up to 3.0 mg.kg-1 . The results indicated that 7-NI-loaded nanoemulsions are safe, constituting a promising approach to treating sepsis., Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF
13. Efficacy and Safety of Ketamine in the Treatment of Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Author
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Guimarães Pereira JE, Ferreira Gomes Pereira L, Mercante Linhares R, Darcy Alves Bersot C, Aslanidis T, and Ashmawi HA
- Abstract
Purpose: Ketamine is a N-methyl-D-aspartate (NMDA) antagonist with strong analgesic properties. Its addition to the treatment of neuropathic pain may reduce pain intensity and improve overall quality of life. A systematic review and meta-analysis of randomized controlled trials was performed to investigate the addition of ketamine to the treatment of patients with neuropathic pain., Patients and Methods: GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach was used to rate the overall certainty of the evidence for each outcome. Eighteen (18) randomized controlled trials including 706 participants were included for further analysis., Results: Ketamine addition to standard treatment of neuropathic pain (NP) resulted in a statistically significant reduction of pain intensity at one week after the end of treatment with ketamine (MD -2.14, 95% CI -2.65 to -1.63; p<0.00001) and after 30 days after the end of treatment with ketamine (MD -1.68, 95% CI -2.25 to -1.12; p<0.00001) and a statistically significant increase in discomfort (RR 4.06; 95% CI 1.18 to 13.95; p=0.03), and psychedelic effects (RR 4.94; 95% CI 2.76 to 8.84; p<0.00001)., Conclusion: There is a statistically significant pain reduction by adding ketamine to the treatment of chronic NP when compared to the standard treatment. However, such pain reduction comes at the expense of adverse outcomes, especially psychedelic effects related to the administration of ketamine. However, the overall quality of certainty of evidence is low due to the clinical heterogeneity among the intervention characteristics of the trials analyzed (different administration routes, dosing regimen, therapy durations, different clinical characteristics of the population investigated). Future large multi-centered trials are necessary to confirm or not the results of the present review., Competing Interests: The authors report no conflicts of interest in this work., (© 2022 Guimarães Pereira et al.)
- Published
- 2022
- Full Text
- View/download PDF
14. Adipokines and Metabolic Syndrome: Pluripotent Markers for a Complex Relationship?
- Author
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Gomes-Pereira L and da Silva-Santos JE
- Subjects
- Adiposity, Biomarkers, Humans, Adipokines metabolism, Metabolic Syndrome diagnosis, Metabolic Syndrome metabolism
- Published
- 2022
- Full Text
- View/download PDF
15. Phosphodiesterase-3 inhibitor cilostazol reverses endothelial dysfunction with ageing in rat mesenteric resistance arteries.
- Author
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Moreira HS, Lima-Leal GA, Santos-Rocha J, Gomes-Pereira L, Duarte GP, and Xavier FE
- Subjects
- Animals, Arterial Pressure drug effects, Cilostazol, Endothelium, Vascular metabolism, Male, Mesenteric Arteries cytology, Nitric Oxide metabolism, Nitric Oxide Synthase Type III metabolism, Proto-Oncogene Proteins c-akt metabolism, Rats, Rats, Wistar, Superoxides metabolism, Vasoconstriction drug effects, Vasodilation drug effects, Aging metabolism, Cyclic Nucleotide Phosphodiesterases, Type 3 metabolism, Endothelium, Vascular drug effects, Mesenteric Arteries drug effects, Mesenteric Arteries physiology, Phosphodiesterase 3 Inhibitors pharmacology, Tetrazoles pharmacology
- Abstract
Ageing impairs endothelial function, which is considered a hallmark of the development of cardiovascular diseases in elderly. Cilostazol, a phosphodiesterase-3 inhibitor, has antiplatelet, antithrombotic and protective effects on endothelial cells. Here, we hypothesized that cilostazol could improve endothelial function in mesenteric resistance arteries (MRA) from old rats. Using eight-week cilostazol-treated (100mg/kg/day) or untreated 72-week-old Wistar rats, we evaluate the relaxation to acetylcholine, sodium nitroprusside (SNP), forskolin and isoproterenol and the noradrenaline-induced contraction in MRA. Superoxide anion and nitric oxide (NO) was measured by dihydroethidium- and diaminofluorescein-2-emitted fluorescence, respectively. Normotensive old rats had impaired acetylcholine-induced NO- and EDHF-mediated relaxation and increased noradrenaline vasoconstriction than young rats. This age-associated endothelial dysfunction was restored by cilostazol treatment. Relaxation to SNP, forskolin or isoproterenol remained unmodified by cilostazol. Diaminofluorescein-2-emitted fluorescence was increased while dihydroethidium-emitted was decreased by cilostazol, indicating increased NO and reduced superoxide generation, respectively. Cilostazol improves endothelial function in old MRA without affecting blood pressure. This protective effect of cilostazol could be attributed to reduced oxidative stress, increased NO bioavailability and EDHF-type relaxation. Although these results are preliminary, we believe that should stimulate further interest in cilostazol as an alternative for the treatment of age-related vascular disorders., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
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