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18 results on '"Gomez, Andrea M."'

1. A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner

Author

Traunmüller, Lisa, Schulz, Jan, Ortiz, Raul, Feng, Huijuan, Furlanis, Elisabetta, Gomez, Andrea M, Schreiner, Dietmar, Bischofberger, Josef, Zhang, Chaolin, and Scheiffele, Peter

Subjects
Human Genome, Genetics, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Neurological, Alternative Splicing, Neurons, Synapses, Pyramidal Cells, Interneurons, Hippocampus, CP: Neuroscience, KHDRBS3, alternative splicing, autism, neurexin, neurodevelopmental disorder, neuroligin, object recognition, synapse formation, synaptic plasticity, Biochemistry and Cell Biology, Medical Physiology
Abstract

The specification of synaptic properties is fundamental for the function of neuronal circuits. "Terminal selector" transcription factors coordinate terminal gene batteries that specify cell-type-specific properties. Moreover, pan-neuronal splicing regulators have been implicated in directing neuronal differentiation. However, the cellular logic of how splicing regulators instruct specific synaptic properties remains poorly understood. Here, we combine genome-wide mapping of mRNA targets and cell-type-specific loss-of-function studies to uncover the contribution of the RNA-binding protein SLM2 to hippocampal synapse specification. Focusing on pyramidal cells and somatostatin (SST)-positive GABAergic interneurons, we find that SLM2 preferentially binds and regulates alternative splicing of transcripts encoding synaptic proteins. In the absence of SLM2, neuronal populations exhibit normal intrinsic properties, but there are non-cell-autonomous synaptic phenotypes and associated defects in a hippocampus-dependent memory task. Thus, alternative splicing provides a critical layer of gene regulation that instructs specification of neuronal connectivity in a trans-synaptic manner.

Published
2023

2. Neurexins: molecular codes for shaping neuronal synapses

Author

Gomez, Andrea M, Traunmüller, Lisa, and Scheiffele, Peter

Subjects
Neurosciences, Genetics, Mental Health, Brain Disorders, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Generic health relevance, Alternative Splicing, Animals, Humans, Nerve Tissue Proteins, Receptors, Cell Surface, Synapses, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

The function of neuronal circuits relies on the properties of individual neuronal cells and their synapses. We propose that a substantial degree of synapse formation and function is instructed by molecular codes resulting from transcriptional programmes. Recent studies on the Neurexin protein family and its ligands provide fundamental insight into how synapses are assembled and remodelled, how synaptic properties are specified and how single gene mutations associated with neurodevelopmental and psychiatric disorders might modify the operation of neuronal circuits and behaviour. In this Review, we first summarize insights into Neurexin function obtained from various model organisms. We then discuss the mechanisms and logic of the cell type-specific regulation of Neurexin isoforms, in particular at the level of alternative mRNA splicing. Finally, we propose a conceptual framework for how combinations of synaptic protein isoforms act as 'senders' and 'readers' to instruct synapse formation and the acquisition of cell type-specific and synapse-specific functional properties.

Published
2021

3. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

Author

Luo, Lin, Ambrozkiewicz, Mateusz C, Benseler, Fritz, Chen, Cui, Dumontier, Emilie, Falkner, Susanne, Furlanis, Elisabetta, Gomez, Andrea M, Hoshina, Naosuke, Huang, Wei-Hsiang, Hutchison, Mary Anne, Itoh-Maruoka, Yu, Lavery, Laura A, Li, Wei, Maruo, Tomohiko, Motohashi, Junko, Pai, Emily Ling-Lin, Pelkey, Kenneth A, Pereira, Ariane, Philips, Thomas, Sinclair, Jennifer L, Stogsdill, Jeff A, Traunmüller, Lisa, Wang, Jiexin, Wortel, Joke, You, Wenjia, Abumaria, Nashat, Beier, Kevin T, Brose, Nils, Burgess, Harold A, Cepko, Constance L, Cloutier, Jean-François, Eroglu, Cagla, Goebbels, Sandra, Kaeser, Pascal S, Kay, Jeremy N, Lu, Wei, Luo, Liqun, Mandai, Kenji, McBain, Chris J, Nave, Klaus-Armin, Prado, Marco AM, Prado, Vania F, Rothstein, Jeffrey, Rubenstein, John LR, Saher, Gesine, Sakimura, Kenji, Sanes, Joshua R, Scheiffele, Peter, Takai, Yoshimi, Umemori, Hisashi, Verhage, Matthijs, Yuzaki, Michisuke, Zoghbi, Huda Yahya, Kawabe, Hiroshi, and Craig, Ann Marie

Subjects
Neurosciences, Biotechnology, Genetics, Animals, Female, Gene Targeting, Genes, Reporter, Germ Cells, Integrases, Male, Mice, Mice, Transgenic, Mosaicism, Neurons, Oocytes, Recombination, Genetic, Spermatozoa, Cre-lox, conditional gene targeting, conditional knockin, conditional knockout, conditional reporter, germline recombination, molecular genetics, mosaic recombination, parental sex bias, site-specific recombinase, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines designed for nervous system-specific recombination. Selective maternal or paternal germline recombination is showcased with sample Cre lines. Collated data reveal germline recombination in over half of 64 commonly used Cre driver lines, in most cases with a parental sex bias related to Cre expression in sperm or oocytes. Slight differences among Cre driver lines utilizing common transcriptional control elements affect germline recombination rates. Specific target loci demonstrated differential recombination; thus, reporters are not reliable proxies for another locus of interest. Similar principles apply to other recombinase systems and other genetically targeted organisms. We hereby draw attention to the prevalence of germline recombination and provide guidelines to inform future research for the neuroscience and broader molecular genetics communities.

Published
2020

4. Cellular Functions of the Autism Risk Factor PTCHD1 in Mice

Author

Tora, David, Gomez, Andrea M, Michaud, Jean-Francois, Yam, Patricia T, Charron, Frédéric, and Scheiffele, Peter

Subjects
Intellectual and Developmental Disabilities (IDD), Neurosciences, Stem Cell Research - Nonembryonic - Non-Human, Genetics, Brain Disorders, Autism, Mental Health, Stem Cell Research, Behavioral and Social Science, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Neurological, Animals, Autistic Disorder, Dendrites, Dentate Gyrus, Hippocampus, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurogenesis, Protein Transport, Risk Factors, autism, glutamatergic synapse, mental retardation, retromer, sonic hedgehog, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

The gene patched domain containing 1 (PTCHD1) is mutated in patients with autism spectrum disorders and intellectual disabilities and has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation. We identify a panel of Ptchd1-interacting proteins that include postsynaptic density proteins and the retromer complex, revealing a link to critical regulators of dendritic and postsynaptic trafficking. Ptchd1 knock-out (KO) male mice exhibit cognitive alterations, including defects in a novel object recognition task. To test whether Ptchd1 is required for Shh-dependent signaling, we examined two Shh-dependent cell populations that express high levels of Ptchd1 mRNA: cerebellar granule cell precursors and dentate granule cells in the hippocampus. We found that proliferation of these neuronal precursors was not altered significantly in Ptchd1 KO male mice. We used whole-cell electrophysiology and anatomical methods to assess synaptic function in Ptchd1-deficient dentate granule cells. In the absence of Ptchd1, we observed profound disruption in excitatory/inhibitory balance despite normal dendritic spine density on dentate granule cells. These findings support a critical role of the Ptchd1 protein in the dentate gyrus, but indicate that it is not required for structural synapse formation in dentate granule cells or for Shh-dependent neuronal precursor proliferation.SIGNIFICANCE STATEMENT The mechanisms underlying neuronal and cellular alterations resulting from patched domain containing 1 (Ptchd1) gene mutations are unknown. The results from this study support an association with dendritic trafficking complexes of Ptchd1. Loss-of-function experiments do not support a role in sonic hedgehog-dependent signaling, but reveal a disruption of synaptic transmission in the mouse dentate gyrus. The findings will help to guide ongoing efforts to understand the etiology of neurodevelopmental disorders arising from Ptchd1 deficiency.

Published
2017

5. Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4.

Author

Gomez, Andrea M, Froemke, Robert C, and Burden, Steven J

Subjects
Muscles, Dendritic Spines, Membranes, Animals, Animals, Newborn, Mice, Mutant Strains, Receptors, LDL, Cognition, Maze Learning, Memory, Synaptic Transmission, Neuronal Plasticity, Long-Term Potentiation, CA1 Region, Hippocampal, behavior, hippocampus, learning, long-term potentiation, low-density lipoprotein-related receptor, mouse, neuroscience, synapse, Newborn, CA1 Region, Hippocampal, Mice, Mutant Strains, Receptors, LDL, Biochemistry and Cell Biology
Abstract

Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth. Lrp4-/- mice, rescued for Lrp4 expression selectively in muscle, survive into adulthood and showed profound deficits in cognitive tasks that assess learning and memory. To learn whether synapses form and function aberrantly, we used electrophysiological and anatomical methods to study hippocampal CA3-CA1 synapses. In the absence of Lrp4, the organization of the hippocampus appeared normal, but the frequency of spontaneous release events and spine density on primary apical dendrites were reduced. CA3 input was unable to adequately depolarize CA1 neurons to induce long-term potentiation. Our studies demonstrate a role for Lrp4 in hippocampal function and suggest that patients with mutations in Lrp4 or auto-antibodies to Lrp4 should be evaluated for neurological deficits.

Published
2014

10. State of the climate in 2017

Author

Abernethy, R., Ackerman, Steven A., Adler, R., Albanil Encarnación, Adelina, Aldeco, Laura S., Alfaro, Eric J., Aliaga-Nestares, Vannia, Allan, Richard P., Allan, Rob, Alves, Lincoln M., Amador, Jorge A., Anderson, John, Andreassen, L. M., Argüez, Anthony, Armitage, C., Arndt, Derek S., Avalos, Grinia, Azorin-Molina, César, Báez, Julián, Bardin, M. Yu, Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Beck, H. E., Becker, Andreas, Bedka, Kristopher M., Behe, Carolina, Bell, Gerald D., Bellouin, Nicolas, Belmont, M., Benedetti, Angela, Bernhard, G. H., Berrisford, Paul, Berry, David I., Bhatt, U. S., Bissolli, Peter, Bjerke, J., Blake, Eric S., Blenkinsop, Stephen, Blunden, Jessica, Bolmgren, K., Bosilovich, Michael G., Boucher, Olivier, Bouchon, Marilú, Box, J. E., Boyer, Tim, Braathen, Geir O., Bromwich, David H., Brown, R., Buehler, S., Bulygina, Olga N., Burgess, D., Calderón, Blanca, Camargo, Suzana J., Campbell, Ethan C., Campbell, Jayaka D., Cappelen, J., Carrea, Laura, Carter, Brendan R., Castro, Anabel, Chambers, Don P., Cheng, Lijing, Christiansen, Hanne H., Christy, John R., Chung, E. S., Clem, Kyle R., Coelho, Caio A.S., Coldewey-Egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Costanza, Carol, Covey, Curt, Coy, Lawrence, Cronin, T., Crouch, Jake, Cruzado, Luis, Daniel, Raychelle, Davis, Sean M., Davletshin, S. G., De Eyto, Elvira, De Jeu, Richard A.M., De La Cour, Jacqueline L., De Laat, Jos, De Gasperi, Curtis L., Degenstein, Doug, Deline, P., Demircan, Mesut, Derksen, C., Dewitte, Boris, Dhurmea, R., Di Girolamo, Larry, Diamond, Howard J., Dickerson, C., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolman, A. Johannes, Domingues, Catia M., Domingues, Ricardo, Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Drozdov, D. S., Dunn, Robert J.H., Durre, Imke, Dutton, Geoff S., Eakin, C. Mark, El Kharrim, M., Elkins, James W., Epstein, H. E., Espinoza, Jhan C., Famiglietti, James S., Farmer, J., Farrell, S., Fauchald, P., Fausto, R. S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Forbes, B. C., Foster, Michael J., Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Geiger, Erick F., Gerland, S., Gilson, John, Gobron, Nadine, Goldenberg, Stanley B., Gomez, Andrea M., Goni, Gustavo, Grooß, Jens Uwe, Gruber, Alexander, Guard, Charles P., Gugliemin, Mario, Gupta, S. K., Gutiérrez, Dimitri, Haas, C., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hansen, K., Hanssen-Bauer, L., Harris, Ian, Hartfield, Gail, Heidinger, Andrew K., Heim, Richard R., Helfrich, S., Hemming, D. L., Hendricks, S., Hernández, Rafael, Hernández, Sosa Marieta, Heron, Scott F., Heuzé, C., Hidalgo, Hugo G., Ho, Shu Peng, Hobbs, William R., Horstkotte, T., Huang, Boyin, Hubert, Daan, Hueuzé, Céline, Hurst, Dale F., Ialongo, Iolanda, Ibrahim, M. M., Ijampy, J. A., Inness, Antje, Isaac, Victor, Isaksen, K., Ishii, Masayoshi, Jacobs, Stephanie J., Jeffries, Martin O., Jevrejeva, Svetlana, Jiménez, C., Jin, Xiangze, John, Viju, Johns, William E., Johnsen, Bjørn, Johnson, Bryan, Johnson, Gregory C., Johnson, Kenneth S., Jones, Philip D., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, J. W., Karaköylü, Erdem M., Kato, Seiji, Kazemi, A., Keller, Linda M., Kennedy, John, Kerr, Kenneth, Khan, M. S., Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. J., Klotzbach, Philip J., Knaff, John A., Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Krumpen, T., Ladd, C., Lakatos, Mónika, Lakkala, Kaisa, Lander, Mark A., Landschützer, Peter, Landsea, Chris W., Lankhorst, Matthias, Lavado-Casimiro, Waldo, Lazzara, Matthew A., Lee, S. E., Lee, T. C., Leuliette, Eric, L'Heureux, Michelle, Li, Tim, Lieser, Jan L., Lin, I. I., Mears, Carl A., Liu, Gang, Li, Bailing, Liu, Hongxing, Locarnini, Ricardo, Loeb, Norman G., Long, Craig S., López, Luis A., Lorrey, Andrew M., Loyola, Diego, Lumpkin, Rick, Luo, Jing Jia, Luojus, K., Luthcke, S., Macias-Fauria, M., Malkova, G. V., Manney, Gloria L., Marcellin, Vernie, Marchenko, S. S., Marengo, José A., Marín, Dora, Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martin, A., Martínez, Alejandra G., Martínez-Güingla, Rodney, Martínez-Sánchez, Odalys, Marsh, Benjamin L., Lyman, John M., Massom, Robert A., May, Linda, Mayer, Michael, Mazloff, Matthew, McBride, Charlotte, McCabe, M. F., McCarthy, Mark, Meier, W., Meijers, Andrew J.S., Mekonnen, Ademe, Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Miller, Ben, Miralles, Diego G., Mitchum, Gary T., Mitro, Sukarni, Moat, Ben, Mochizuki, Y., Monselesan, Didier, Montzka, Stephen A., Mora, Natalie, Morice, Colin, Mosquera-Vásquez, Kobi, Mostafa, Awatif E., Mote, T., Mudryk, L., Mühle, Jens, Mullan, A. Brett, Müller, Rolf, Myneni, R., Nash, Eric R., Nerem, R. Steven, Newman, L., Newman, Paul A., Nielsen-Gammon, John W., Nieto, Juan José, Noetzli, Jeannette, Noll, Ben E., O'Neel, S., Osborn, Tim J., Osborne, Emily, Overland, J., Oyunjargal, Lamjav, Park, T., Pasch, Richard J., Pascual-Ramírez, Reynaldo, Pastor Saavedra, Maria Asuncion, Paterson, Andrew M., Paulik, Christoph, Pearce, Petra R., Peltier, Alexandre, Pelto, Mauri S., Peng, Liang, Perkins-Kirkpatrick, Sarah E., Perovich, Don, Petropavlovskikh, Irina, Pezza, Alexandre B., Phillips, C., Phillips, David, Phoenix, G., Pinty, Bernard, Pinzon, J., Po-Chedley, S., Polashenski, C., Purkey, Sarah G., Quispe, Nelson, Rajeevan, Madhavan, Rakotoarimalala, C., Rayner, Darren, Raynolds, M. K., Reagan, James, Reid, Phillip, Reimer, Christoph, Rémy, Samuel, Revadekar, Jayashree V., Richardson, A. D., Richter-Menge, Jacqueline, Ricker, R., Rimmer, Alon, Robinson, David A., Rodell, Matthew, Rodriguez Camino, Ernesto, Romanovsky, Vladimir E., Ronchail, Josyane, Rosenlof, Karen H., Rösner, Benjamin, Roth, Chris, Roth, David Mark, Rusak, James A., Rutishäuser, T., Sallée, Jean Bapiste, Sánchez-Lugo, Ahira, Santee, Michelle L., Sasgen, L., Sawaengphokhai, P., Sayad, T. A., Sayouri, Amal, Scambos, Ted A., Scanlon, T., Schenzinger, Verena, Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schreck, Carl J., Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Sharp, M., Shi, Lei, Shiklomanov, Nikolai I., Shimaraeva, Svetlana V., Siegel, David A., Silow, Eugene, Sima, Fatou, Simmons, Adrian J., Skirving, William J., Smeed, David A., Smeets, C. J.P.P., Smith, Adam, Smith, Sharon L., Soden, B., Sofieva, Viktoria, Sparks, T. H., Spence, Jacqueline M., Spillane, Sandra, Srivastava, A. K., Stackhouse, Paul W., Stammerjohn, Sharon, Stanitski, Diane M., Steinbrecht, Wolfgang, Stella, José L., Stengel, M., Stephenson, Kimberly, Stephenson, Tannecia S., Strahan, Susan, Streletskiy, Dimitri A., Strong, Alan E., Sun-Mack, Sunny, Sutton, Adrienne J., Swart, Sebastiaan, Sweet, William, Takahashi, Kenneth S., Tamar, Gerard, Taylor, Michael A., Tedesco, M., Thackeray, S. J., Thoman, R. L., Thompson, Philip, Thomson, L., Thorsteinsson, T., Timbal, Bertrand, Timmermans, M. L., TImofeyev, Maxim A., Tirak, Kyle V., Tobin, Skie, Togawa, H., Tømmervik, H., Tourpali, Kleareti, Trachte, Katja, Trewin, Blair C., Triñanes, Joaquin A., Trotman, Adrian R., Tschudi, M., Tucker, C. J., Tye, Mari R., Van As, D., Van De Wal, R. S.W., Van Der Ronald, J. A., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velden, Christopher S., Velicogna, I., Verburg, Piet, Vickers, H., Vincent, Lucie A., Vömel, Holger, Vose, Russell S., Wagner, Wolfgang, Walker, D. A., Walsh, J., Wang, Bin, Wang, Junhong, Wang, Lei, Wang, M., Wang, Ray, Wang, Sheng Hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Webster, M., Weller, Robert A., Westberry, Toby K., Weyhenmeyer, Gesa A., Whitewood, Robert, Widlansky, Matthew J., Wiese, David N., Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Willis, Josh K., Wolken, G., Wong, Takmeng, Wood, E. F., Wood, K., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yin, Xungang, Yoon, Huang, York, A., Yu, Lisan, Zambrano, Eduardo, Zhang, Huai Min, Zhang, Peiqun, Zhao, Guanguo, Zhao, Lin, Zhu, Zhiwei, Ziel, R., Ziemke, Jerry R., Ziese, Markus G., Griffin, Jessicca, Hammer, Gregory, Love-Brotak, S. Elizabeth, Misch, Deborah J., Riddle, Deborah B., Slagle, Mary, Sprain, Mara, Veasey, Sara W., McVicar, Tim R., Sub Dynamics Meteorology, Sub Soft Condensed Matter, LS Religiewetenschap, Sub Atmospheric physics and chemistry, Zonder bezoldiging NED, LS Taalverwerving, Leerstoel Tubergen, Afd Chemical Biology and Drug Discovery, Hafd Faculteitsbureau GW, Afd Pharmacology, Dep IRAS, Marine and Atmospheric Research, and OFR - Religious Studies

Subjects
Atmospheric Science
Abstract

In 2017, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-reached new record highs. The annual global average carbon dioxide concentration at Earth's surface for 2017 was 405.0 ± 0.1 ppm, 2.2 ppm greater than for 2016 and the highest in the modern atmospheric measurement record and in ice core records dating back as far as 800 000 years. The global growth rate of CO2 has nearly quadrupled since the early 1960s. With ENSO-neutral conditions present in the central and eastern equatorial Pacific Ocean during most of the year and weak La Niña conditions notable at the start and end, the global temperature across land and ocean surfaces ranked as the second or third highest, depending on the dataset, since records began in the mid-to-late 1800s. Notably, it was the warmest non-El Niño year in the instrumental record. Above Earth's surface, the annual lower tropospheric temperature was also either second or third highest according to all datasets analyzed. The lower stratospheric temperature was about 0.2°C higher than the record cold temperature of 2016 according to most of the in situ and satellite datasets. Several countries, including Argentina, Uruguay, Spain, and Bulgaria, reported record high annual temperatures. Mexico broke its annual record for the fourth consecutive year. On 27 January, the temperature reached 43.4°C at Puerto Madryn, Argentina-the highest temperature recorded so far south (43°S) anywhere in the world. On 28 May in Turbat, western Pakistan, the high of 53.5°C tied Pakistan's all-time highest temperature and became the world-record highest temperature for May. In the Arctic, the 2017 land surface temperature was 1.6°C above the 1981-2010 average, the second highest since the record began in 1900, behind only 2016. The five highest annual Arctic temperatures have all occurred since 2007. Exceptionally high temperatures were observed in the permafrost across the Arctic, with record values reported in much of Alaska and northwestern Canada. In August, high sea surface temperature (SST) records were broken for the Chukchi Sea, with some regions as warm as +11°C, or 3° to 4°C warmer than the longterm mean (1982-present). According to paleoclimate studies, today's abnormally warm Arctic air and SSTs have not been observed in the last 2000 years. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 7 March, sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, covering 8% less area than the 1981-2010 average. The Arctic sea ice minimum on 13 September was the eighth lowest on record and covered 25% less area than the long-term mean. Preliminary data indicate that glaciers across the world lost mass for the 38th consecutive year on record; the declines are remarkably consistent from region to region. Cumulatively since 1980, this loss is equivalent to slicing 22 meters off the top of the average glacier. Antarctic sea ice extent remained below average for all of 2017, with record lows during the first four months. Over the continent, the austral summer seasonal melt extent and melt index were the second highest since 2005, mostly due to strong positive anomalies of air temperature over most of the West Antarctic coast. In contrast, the East Antarctic Plateau saw record low mean temperatures in March. The year was also distinguished by the second smallest Antarctic ozone hole observed since 1988. Across the global oceans, the overall long-term SST warming trend remained strong. Although SST cooled slightly from 2016 to 2017, the last three years produced the three highest annual values observed; these high anomalies have been associated with widespread coral bleaching. The most recent global coral bleaching lasted three full years, June 2014 to May 2017, and was the longest, most widespread, and almost certainly most destructive such event on record. Global integrals of 0-700-m and 0-2000-m ocean heat content reached record highs in 2017, and global mean sea level during the year became the highest annual average in the 25-year satellite altimetry record, rising to 77 mm above the 1993 average. In the tropics, 2017 saw 85 named tropical storms, slightly above the 1981-2010 average of 82. The North Atlantic basin was the only basin that featured an above-normal season, its seventh most active in the 164-year record. Three hurricanes in the basin were especially notable. Harvey produced record rainfall totals in areas of Texas and Louisiana, including a storm total of 1538.7 mm near Beaumont, Texas, which far exceeds the previous known U.S. tropical cyclone record of 1320.8 mm. Irma was the strongest tropical cyclone globally in 2017 and the strongest Atlantic hurricane outside of the Gulf of Mexico and Caribbean on record with maximum winds of 295 km h-1. Maria caused catastrophic destruction across the Caribbean Islands, including devastating wind damage and flooding across Puerto Rico. Elsewhere, the western North Pacific, South Indian, and Australian basins were all particularly quiet. Precipitation over global land areas in 2017 was clearly above the long-term average. Among noteworthy regional precipitation records in 2017, Russia reported its second wettest year on record (after 2013) and Norway experienced its sixth wettest year since records began in 1900. Across India, heavy rain and flood-related incidents during the monsoon season claimed around 800 lives. In August and September, above-normal precipitation triggered the most devastating floods in more than a decade in the Venezuelan states of Bolívar and Delta Amacuro. In Nigeria, heavy rain during August and September caused the Niger and Benue Rivers to overflow, bringing floods that displaced more than 100 000 people. Global fire activity was the lowest since at least 2003; however, high activity occurred in parts of North America, South America, and Europe, with an unusually long season in Spain and Portugal, which had their second and third driest years on record, respectively. Devastating fires impacted British Columbia, destroying 1.2 million hectares of timber, bush, and grassland, due in part to the region's driest summer on record. In the United States, an extreme western wildfire season burned over 4 million hectares; the total costs of $18 billion tripled the previous U.S. annual wildfire cost record set in 1991.

Published
2018

11. State of the Climate in 2017

Author

Arndt, D. S., Blunden, J., Hartfield, G., Ackerman, Steven A., Adler, Robert, Alfaro, Eric J., Allan, Richard P., Allan, Rob, Alves, Lincoln M., Amador, Jorge A., Andreassen, L. M., Argueez, Anthony, Arndt, Derek S., Azorin-molina, Cesar, Baez, Julian, Bardin, M. U., Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Beck, H. E., Becker, Andreas, Bedka, Kristopher M., Bell, Gerald D., Belmont, M., Benedetti, Angela, Berrisford, Paul, Berry, David I., Bhatt, U. S., Bissolli, Peter, Bjerke, J., Blake, Eric S., Bosilovich, Michael G., Boucher, Olivier, Box, J. E., Boyer, Tim, Braathen, Geir O., Bromwich, David H., Brown, R., Buehler, S., Bulygina, Olga N., Burgess, D., Calderon, Blanca, Camargo, Suzana J., Campbell, Jayaka D., Cappelen, J., Carrea, Laura, Carter, Brendan R., Chambers, Don P., Cheng, Ming-dean, Christiansen, Hanne H., Christy, John R., Chung, E. -s., Clem, Kyle R., Coelho, Caio A. S., Coldewey-egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Crouch, Jake, Davis, Sean M., De Eyto, Elvira, De Jeu, Richard A. M., De Laat, Jos, Degasperi, Curtis L., Degenstein, Doug, Demircan, M., Derksen, C., Di Girolamo, Larry, Diamond, Howard J., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolman, A. Johannes, Domingues, Catia M., Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Drozdov, D. S., Dunn, Robert J. H., Dutton, Geoff S., Elkharrim, M., Elkins, James W., Epstein, H. E., Espinoza, Jhan C., Famiglietti, James S., Farrell, S., Fausto, R. S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Forbes, B. C., Foster, Michael J., Francis, S. 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S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Forbes, B. C., Foster, Michael J., Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Gerland, S., Gilson, John, Gobron, Nadine, Goldenberg, Stanley B., Goni, Gustavo, Grooss, J. -u., Gruber, Alexander, Guard, Charles, Gupta, S. K., Gutierrez, J. M., Haas, C., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hanssen-bauer, I, Harris, Ian, Heidinger, Andrew K., Heim, Richard R., Jr., Hendricks, S., Hernandez, Marieta, Hernandez, Rafael, Hidalgo, Hugo G., Ho, Shu-peng, Hobbs, William R., Huang, Boyin, Hurst, Dale F., Ialongo, I., Ijampy, J. A., Inness, Antje, Isaksen, K., Ishii, Masayoshi, Jevrejeva, Svetlana, Jimenez, C., Jin Xiangze, John, Viju, Johns, William E., Johnsen, B., Johnson, Bryan, Johnson, Gregory C., Johnson, Kenneth S., Jones, Philip D., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, J. W., Kato, Seiji, Kazemi, A., Keller, Linda M., Kennedy, John, Kerr, Kenneth, Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. -j., Klotzbach, Philip J., Knaff, John A., Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Krumpen, T., Lakatos, M., Lakkala, K., Lander, Mark A., Landschuetzer, Peter, Landsea, Chris W., Lankhorst, Matthias, Lazzara, Matthew A., Leuliette, Eric, L'Heureux, Michelle, Lieser, Jan L., Lin, I-i, Liu, Hongxing, Liu, Yinghui, Locarnini, Ricardo, Loeb, Norman G., Long, Craig S., Lorrey, Andrew M., Loyola, Diego, Lumpkin, Rick, Luo, Jing-jia, Luojus, K., Lyman, John M., Macias-fauria, M., Malkova, G. V., Manney, G., Marchenko, S. S., Marengo, Jose A., Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martinez-gueingla, Rodney, Massom, Robert A., May, Linda, Mayer, Michael, Mazloff, Matthew, Mcbride, Charlotte, Mccabe, M. F., Mccarthy, M., Mcvicar, Tim R., Mears, Carl A., Meier, W., Mekonnen, A., Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Miralles, Diego G., Mitchum, Gary T., Mitro, Srkani, Monselesan, Didier, Montzka, Stephen A., Mora, Natalie, Morice, Colin, Mote, T., Mudryk, L., Muehle, Jens, Mullan, A. Brett, Mueller, R., Nash, Eric R., Nerem, R. Steven, Newman, Louise, Newman, Paul A., Nieto, Juan Jose, Noetzli, Jeannette, O'Neel, S., Osborn, Tim J., Overland, J., Oyunjargal, Lamjav, Park, E-hyung, Pasch, Richard J., Pascual-ramirez, Reynaldo, Paterson, Andrew M., Pearce, Petra R., Pelto, Mauri S., Perkins-kirkpatrick, Sarah E., Perovich, D., Petropavlovskikh, Irina, Pezza, Alexandre B., Phillips, C., Phillips, David, Phoenix, G., Pinty, Bernard, Rajeevan, Madhavan, Rayner, Darren, Raynolds, M. K., Reagan, James, Reid, Phillip, Reimer, Christoph, Remy, Samuel, Revadekar, Jayashree V., Richter-menge, J., Rimmer, Alon, Robinson, David A., Rodell, Matthew, Romanovsky, Vladimir E., Ronchail, Josyane, Rosenlof, Karen H., Roth, Chris, Rusak, James A., Sallee, Jean-bapiste, Sanchez-lugo, Ahira, Santee, Michelle L., Sawaengphokhai, P., Sayouri, Amal, Scambos, Ted A., Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schreck, Carl J., Iii, Schuur, Ted, Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Sharp, M., Shi, Lei, Shiklomanov, Nikolai I., Shimaraeva, Svetlana V., Siegel, David A., Signorini, Sergio R., Sima, Fatou, Simmons, Adrian J., Smeed, David A., Smeets, C. J. P. P., Smith, Adam, Smith, Sharon L., Soden, B., Spence, Jaqueline M., Srivastava, A. K., Stackhouse, Paul W., Jr., Stammerjohn, Sharon, Steinbrecht, Wolfgang, Stella, Jose L., Stephenson, Tannecia S., Strahan, Susan, Streletskiy, Dimitri A., Sun-mack, Sunny, Swart, Sebastiaan, Sweet, William, Tamar, Gerard, Taylor, Michael A., Tedesco, M., Thoman, R. L., Thompson, L., Thompson, Philip R., Timmermans, M. -l., Tobin, Skie, Trachte, Katja, Trewin, Blair C., Trotman, Adrian R., Tschudi, M., Van As, D., Van De Wal, R. S. W., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velicogna, I., Verburg, Piet, Vincent, Lucie A., Voemel, Holger, Vose, Russell S., Wagner, Wolfgang, Walker, D. A., Walsh, J., Wang, Bin, Wang, Chunzai, Wang, Junhong, Wang, Lei, Wang, M., Wang, Sheng-hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Weller, Robert A., Weyhenmeyer, Gesa A., Whitewood, Robert, Wiese, David N., Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Willis, Josh K., Wolken, G., Wong, Takmeng, Wood, E. F., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yin, Xungang, Yu, Lisan, Zambrano, Eduardo, Zhang, Huai-min, Zhang, Peiqun, Zhao, Guanguo, Zhao, Lin, Ziemke, Jerry R., Abernethy, R., Albanil, Encarnacion Adelina, Aldeco, Laura S., Aliaga-nestares, Vannia, Anderson, John, Armitage, C., Avalos, Grinia, Behe, Carolina, Bellouin, Nicolas, Bernhard, G. H., Blenkinsop, Stephen, Bolmgren, K., Bouchon, Marilu, Campbell, Ethan C., Castro, Anabel, Costanza, Carol, Covey, Curt, Coy, Lawrence, Cronin, T., Cruzado, Luis, Daniel, Raychelle, Davletshin, S. G., De La Cour, Jacqueline L., Deline, P., Dewitte, Boris, Dhurmea, R., Dickerson, C., Domingues, Ricardo, Durre, Imke, Eakin, C. Mark, Farmer, J., Fauchald, P., Geiger, Erick F., Gomez, Andrea M., Gugliemin, Mario, Hansen, K., Helfrich, S., Hemming, D. L., Heron, Scott F., Heuze, C., Horstkotte, T., Hubert, Daan, Hueuze, Celine, Ibrahim, M. M., Isaac, Victor, Jacobs, Stephanie J., Jeffries, Martin O., Karakoylu, Erdem M., Khan, M. S., Ladd, C., Lavado-casimiro, Waldo, Lee, S. -e, Lee, T. C., Li, Bailing, Li, Tim, Lopez, Luis A., Luthcke, S., Marcellin, Vernie, Marin, Dora, Marsh, Benjamin L., Martin, A, Martinez, Alejandra G., Martinez-sanchez, Odalys, Meijers, Andrew J. S., Miller, Ben, Moat, Ben, Mochizuki, Y., Mosquera-vasquez, Kobi, Mostafa, Awatif E., Nielsen-gammon, John W., Noll, Ben E., Osborne, Emily, Pastor, Saavedra Maria Asuncion, Paulik, Christoph, Peltier, Alexandre, Pinzon, J., Po-chedley, S., Polashenski, C., Purkey, Sarah G., Quispe, Nelson, Rakotoarimalala, C., Richardson, A. D., Ricker, R, Rodriguez, Camino Ernesto, Rosner, Benjamin, Roth, David Mark, Rutishauser, T., Sasgen, L., Sayad, T. A., Scanlon, T., Schenzinger, Verena, Silow, Eugene, Skirving, William J., Sofieva, Viktoria, Sparks, T. H., Spillane, Sandra, Stanitski, Diane M., Stengel, M., Stephenson, Kimberly, Strong, Alan E., Sutton, Adrienne J., Takahashi, Kenneth S., Thackeray, S. J., Thomson, Lthorsteinsson T., Timbal, Bertrand, Timofeyev, Maxim A., Tirak, Kyle, V, Togawa, H., Tommervik, H., Tourpali, Kleareti, Trinanes, Joaquin A., Tucker, C. J., Tye, Mari R., Van Der A, Ronald J., Velden, Christopher S., Vickers, H., Webster, M., Westberry, Toby K., Widlansky, Matthew J., Wood, K., Yoon, Huang, York, A., Zhu, Zhiwei, Ziel, R., and Ziese, Markus G.

Abstract

In 2017, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide— reached new record highs. The annual global average carbon dioxide concentration at Earth’s surface for 2017 was 405.0 ± 0.1 ppm, 2.2 ppm greater than for 2016 and the highest in the modern atmospheric measurement record and in ice core records dating back as far as 800 000 years. The global growth rate of CO2 has nearly quadrupled since the early 1960s. With ENSO-neutral conditions present in the central and eastern equatorial Pacific Ocean during most of the year and weak La Niña conditions notable at the start and end, the global temperature across land and ocean surfaces ranked as the second or third highest, depending on the dataset, since records began in the mid-to-late 1800s. Notably, it was the warmest non-El Niño year in the instrumental record. Above Earth’s surface, the annual lower tropospheric temperature was also either second or third highest according to all datasets analyzed. The lower stratospheric temperature was about 0.2°C higher than the record cold temperature of 2016 according to most of the in situ and satellite datasets. Several countries, including Argentina, Uruguay, Spain, and Bulgaria, reported record high annual temperatures. Mexico broke its annual record for the fourth consecutive year. On 27 January, the temperature reached 43.4°C at Puerto Madryn, Argentina—the highest temperature recorded so far south (43°S) anywhere in the world. On 28 May in Turbat, western Pakistan, the high of 53.5°C tied Pakistan’s all-time highest temperature and became the world-record highest temperature for May. In the Arctic, the 2017 land surface temperature was 1.6°C above the 1981–2010 average, the second highest since the record began in 1900, behind only 2016. The five highest annual Arctic temperatures have all occurred since 2007. Exceptionally high temperatures were observed in the permafrost across the Arctic, with record values r

Published
2018
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12. State of the climate in 2017

Author

Sub Dynamics Meteorology, Sub Soft Condensed Matter, LS Religiewetenschap, Sub Atmospheric physics and chemistry, Zonder bezoldiging NED, LS Taalverwerving, Leerstoel Tubergen, Afd Chemical Biology and Drug Discovery, Hafd Faculteitsbureau GW, Afd Pharmacology, Dep IRAS, Marine and Atmospheric Research, OFR - Religious Studies, Abernethy, R., Ackerman, Steven A., Adler, R., Albanil Encarnación, Adelina, Aldeco, Laura S., Alfaro, Eric J., Aliaga-Nestares, Vannia, Allan, Richard P., Allan, Rob, Alves, Lincoln M., Amador, Jorge A., Anderson, John, Andreassen, L. M., Argüez, Anthony, Armitage, C., Arndt, Derek S., Avalos, Grinia, Azorin-Molina, César, Báez, Julián, Bardin, M. Yu, Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Beck, H. E., Becker, Andreas, Bedka, Kristopher M., Behe, Carolina, Bell, Gerald D., Bellouin, Nicolas, Belmont, M., Benedetti, Angela, Bernhard, G. H., Berrisford, Paul, Berry, David I., Bhatt, U. S., Bissolli, Peter, Bjerke, J., Blake, Eric S., Blenkinsop, Stephen, Blunden, Jessica, Bolmgren, K., Bosilovich, Michael G., Boucher, Olivier, Bouchon, Marilú, Box, J. E., Boyer, Tim, Braathen, Geir O., Bromwich, David H., Brown, R., Buehler, S., Bulygina, Olga N., Burgess, D., Calderón, Blanca, Camargo, Suzana J., Campbell, Ethan C., Campbell, Jayaka D., Cappelen, J., Carrea, Laura, Carter, Brendan R., Castro, Anabel, Chambers, Don P., Cheng, Lijing, Christiansen, Hanne H., Christy, John R., Chung, E. S., Clem, Kyle R., Coelho, Caio A.S., Coldewey-Egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Costanza, Carol, Covey, Curt, Coy, Lawrence, Cronin, T., Crouch, Jake, Cruzado, Luis, Daniel, Raychelle, Davis, Sean M., Davletshin, S. G., De Eyto, Elvira, De Jeu, Richard A.M., De La Cour, Jacqueline L., De Laat, Jos, De Gasperi, Curtis L., Degenstein, Doug, Deline, P., Demircan, Mesut, Derksen, C., Dewitte, Boris, Dhurmea, R., Di Girolamo, Larry, Diamond, Howard J., Dickerson, C., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolman, A. Johannes, Domingues, Catia M., Domingues, Ricardo, Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Drozdov, D. S., Dunn, Robert J.H., Durre, Imke, Dutton, Geoff S., Eakin, C. Mark, El Kharrim, M., Elkins, James W., Epstein, H. E., Espinoza, Jhan C., Famiglietti, James S., Farmer, J., Farrell, S., Fauchald, P., Fausto, R. S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Forbes, B. C., Foster, Michael J., Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Geiger, Erick F., Gerland, S., Gilson, John, Gobron, Nadine, Goldenberg, Stanley B., Gomez, Andrea M., Goni, Gustavo, Grooß, Jens Uwe, Gruber, Alexander, Guard, Charles P., Gugliemin, Mario, Gupta, S. K., Gutiérrez, Dimitri, Haas, C., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hansen, K., Hanssen-Bauer, L., Harris, Ian, Hartfield, Gail, Heidinger, Andrew K., Heim, Richard R., Helfrich, S., Hemming, D. L., Hendricks, S., Hernández, Rafael, Hernández, Sosa Marieta, Heron, Scott F., Heuzé, C., Hidalgo, Hugo G., Ho, Shu Peng, Hobbs, William R., Horstkotte, T., Huang, Boyin, Hubert, Daan, Hueuzé, Céline, Hurst, Dale F., Ialongo, Iolanda, Ibrahim, M. M., Ijampy, J. A., Inness, Antje, Isaac, Victor, Isaksen, K., Ishii, Masayoshi, Jacobs, Stephanie J., Jeffries, Martin O., Jevrejeva, Svetlana, Jiménez, C., Jin, Xiangze, John, Viju, Johns, William E., Johnsen, Bjørn, Johnson, Bryan, Johnson, Gregory C., Johnson, Kenneth S., Jones, Philip D., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, J. W., Karaköylü, Erdem M., Kato, Seiji, Kazemi, A., Keller, Linda M., Kennedy, John, Kerr, Kenneth, Khan, M. S., Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. J., Klotzbach, Philip J., Knaff, John A., Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Krumpen, T., Ladd, C., Lakatos, Mónika, Lakkala, Kaisa, Lander, Mark A., Landschützer, Peter, Landsea, Chris W., Lankhorst, Matthias, Lavado-Casimiro, Waldo, Lazzara, Matthew A., Lee, S. E., Lee, T. C., Leuliette, Eric, L'Heureux, Michelle, Li, Tim, Lieser, Jan L., Lin, I. I., Mears, Carl A., Liu, Gang, Li, Bailing, Liu, Hongxing, Locarnini, Ricardo, Loeb, Norman G., Long, Craig S., López, Luis A., Lorrey, Andrew M., Loyola, Diego, Lumpkin, Rick, Luo, Jing Jia, Luojus, K., Luthcke, S., Macias-Fauria, M., Malkova, G. V., Manney, Gloria L., Marcellin, Vernie, Marchenko, S. S., Marengo, José A., Marín, Dora, Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martin, A., Martínez, Alejandra G., Martínez-Güingla, Rodney, Martínez-Sánchez, Odalys, Marsh, Benjamin L., Lyman, John M., Massom, Robert A., May, Linda, Mayer, Michael, Mazloff, Matthew, McBride, Charlotte, McCabe, M. F., McCarthy, Mark, Meier, W., Meijers, Andrew J.S., Mekonnen, Ademe, Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Miller, Ben, Miralles, Diego G., Mitchum, Gary T., Mitro, Sukarni, Moat, Ben, Mochizuki, Y., Monselesan, Didier, Montzka, Stephen A., Mora, Natalie, Morice, Colin, Mosquera-Vásquez, Kobi, Mostafa, Awatif E., Mote, T., Mudryk, L., Mühle, Jens, Mullan, A. Brett, Müller, Rolf, Myneni, R., Nash, Eric R., Nerem, R. 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D., Richter-Menge, Jacqueline, Ricker, R., Rimmer, Alon, Robinson, David A., Rodell, Matthew, Rodriguez Camino, Ernesto, Romanovsky, Vladimir E., Ronchail, Josyane, Rosenlof, Karen H., Rösner, Benjamin, Roth, Chris, Roth, David Mark, Rusak, James A., Rutishäuser, T., Sallée, Jean Bapiste, Sánchez-Lugo, Ahira, Santee, Michelle L., Sasgen, L., Sawaengphokhai, P., Sayad, T. A., Sayouri, Amal, Scambos, Ted A., Scanlon, T., Schenzinger, Verena, Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schreck, Carl J., Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Sharp, M., Shi, Lei, Shiklomanov, Nikolai I., Shimaraeva, Svetlana V., Siegel, David A., Silow, Eugene, Sima, Fatou, Simmons, Adrian J., Skirving, William J., Smeed, David A., Smeets, C. J.P.P., Smith, Adam, Smith, Sharon L., Soden, B., Sofieva, Viktoria, Sparks, T. H., Spence, Jacqueline M., Spillane, Sandra, Srivastava, A. K., Stackhouse, Paul W., Stammerjohn, Sharon, Stanitski, Diane M., Steinbrecht, Wolfgang, Stella, José L., Stengel, M., Stephenson, Kimberly, Stephenson, Tannecia S., Strahan, Susan, Streletskiy, Dimitri A., Strong, Alan E., Sun-Mack, Sunny, Sutton, Adrienne J., Swart, Sebastiaan, Sweet, William, Takahashi, Kenneth S., Tamar, Gerard, Taylor, Michael A., Tedesco, M., Thackeray, S. J., Thoman, R. L., Thompson, Philip, Thomson, L., Thorsteinsson, T., Timbal, Bertrand, Timmermans, M. L., TImofeyev, Maxim A., Tirak, Kyle V., Tobin, Skie, Togawa, H., Tømmervik, H., Tourpali, Kleareti, Trachte, Katja, Trewin, Blair C., Triñanes, Joaquin A., Trotman, Adrian R., Tschudi, M., Tucker, C. J., Tye, Mari R., Van As, D., Van De Wal, R. S.W., Van Der Ronald, J. A., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velden, Christopher S., Velicogna, I., Verburg, Piet, Vickers, H., Vincent, Lucie A., Vömel, Holger, Vose, Russell S., Wagner, Wolfgang, Walker, D. A., Walsh, J., Wang, Bin, Wang, Junhong, Wang, Lei, Wang, M., Wang, Ray, Wang, Sheng Hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Webster, M., Weller, Robert A., Westberry, Toby K., Weyhenmeyer, Gesa A., Whitewood, Robert, Widlansky, Matthew J., Wiese, David N., Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Willis, Josh K., Wolken, G., Wong, Takmeng, Wood, E. F., Wood, K., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yin, Xungang, Yoon, Huang, York, A., Yu, Lisan, Zambrano, Eduardo, Zhang, Huai Min, Zhang, Peiqun, Zhao, Guanguo, Zhao, Lin, Zhu, Zhiwei, Ziel, R., Ziemke, Jerry R., Ziese, Markus G., Griffin, Jessicca, Hammer, Gregory, Love-Brotak, S. Elizabeth, Misch, Deborah J., Riddle, Deborah B., Slagle, Mary, Sprain, Mara, Veasey, Sara W., McVicar, Tim R., Sub Dynamics Meteorology, Sub Soft Condensed Matter, LS Religiewetenschap, Sub Atmospheric physics and chemistry, Zonder bezoldiging NED, LS Taalverwerving, Leerstoel Tubergen, Afd Chemical Biology and Drug Discovery, Hafd Faculteitsbureau GW, Afd Pharmacology, Dep IRAS, Marine and Atmospheric Research, OFR - Religious Studies, Abernethy, R., Ackerman, Steven A., Adler, R., Albanil Encarnación, Adelina, Aldeco, Laura S., Alfaro, Eric J., Aliaga-Nestares, Vannia, Allan, Richard P., Allan, Rob, Alves, Lincoln M., Amador, Jorge A., Anderson, John, Andreassen, L. M., Argüez, Anthony, Armitage, C., Arndt, Derek S., Avalos, Grinia, Azorin-Molina, César, Báez, Julián, Bardin, M. Yu, Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Beck, H. E., Becker, Andreas, Bedka, Kristopher M., Behe, Carolina, Bell, Gerald D., Bellouin, Nicolas, Belmont, M., Benedetti, Angela, Bernhard, G. H., Berrisford, Paul, Berry, David I., Bhatt, U. S., Bissolli, Peter, Bjerke, J., Blake, Eric S., Blenkinsop, Stephen, Blunden, Jessica, Bolmgren, K., Bosilovich, Michael G., Boucher, Olivier, Bouchon, Marilú, Box, J. E., Boyer, Tim, Braathen, Geir O., Bromwich, David H., Brown, R., Buehler, S., Bulygina, Olga N., Burgess, D., Calderón, Blanca, Camargo, Suzana J., Campbell, Ethan C., Campbell, Jayaka D., Cappelen, J., Carrea, Laura, Carter, Brendan R., Castro, Anabel, Chambers, Don P., Cheng, Lijing, Christiansen, Hanne H., Christy, John R., Chung, E. S., Clem, Kyle R., Coelho, Caio A.S., Coldewey-Egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Costanza, Carol, Covey, Curt, Coy, Lawrence, Cronin, T., Crouch, Jake, Cruzado, Luis, Daniel, Raychelle, Davis, Sean M., Davletshin, S. G., De Eyto, Elvira, De Jeu, Richard A.M., De La Cour, Jacqueline L., De Laat, Jos, De Gasperi, Curtis L., Degenstein, Doug, Deline, P., Demircan, Mesut, Derksen, C., Dewitte, Boris, Dhurmea, R., Di Girolamo, Larry, Diamond, Howard J., Dickerson, C., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolman, A. Johannes, Domingues, Catia M., Domingues, Ricardo, Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Drozdov, D. S., Dunn, Robert J.H., Durre, Imke, Dutton, Geoff S., Eakin, C. Mark, El Kharrim, M., Elkins, James W., Epstein, H. E., Espinoza, Jhan C., Famiglietti, James S., Farmer, J., Farrell, S., Fauchald, P., Fausto, R. S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Forbes, B. C., Foster, Michael J., Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Geiger, Erick F., Gerland, S., Gilson, John, Gobron, Nadine, Goldenberg, Stanley B., Gomez, Andrea M., Goni, Gustavo, Grooß, Jens Uwe, Gruber, Alexander, Guard, Charles P., Gugliemin, Mario, Gupta, S. K., Gutiérrez, Dimitri, Haas, C., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hansen, K., Hanssen-Bauer, L., Harris, Ian, Hartfield, Gail, Heidinger, Andrew K., Heim, Richard R., Helfrich, S., Hemming, D. L., Hendricks, S., Hernández, Rafael, Hernández, Sosa Marieta, Heron, Scott F., Heuzé, C., Hidalgo, Hugo G., Ho, Shu Peng, Hobbs, William R., Horstkotte, T., Huang, Boyin, Hubert, Daan, Hueuzé, Céline, Hurst, Dale F., Ialongo, Iolanda, Ibrahim, M. M., Ijampy, J. A., Inness, Antje, Isaac, Victor, Isaksen, K., Ishii, Masayoshi, Jacobs, Stephanie J., Jeffries, Martin O., Jevrejeva, Svetlana, Jiménez, C., Jin, Xiangze, John, Viju, Johns, William E., Johnsen, Bjørn, Johnson, Bryan, Johnson, Gregory C., Johnson, Kenneth S., Jones, Philip D., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, J. W., Karaköylü, Erdem M., Kato, Seiji, Kazemi, A., Keller, Linda M., Kennedy, John, Kerr, Kenneth, Khan, M. S., Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. J., Klotzbach, Philip J., Knaff, John A., Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Krumpen, T., Ladd, C., Lakatos, Mónika, Lakkala, Kaisa, Lander, Mark A., Landschützer, Peter, Landsea, Chris W., Lankhorst, Matthias, Lavado-Casimiro, Waldo, Lazzara, Matthew A., Lee, S. E., Lee, T. C., Leuliette, Eric, L'Heureux, Michelle, Li, Tim, Lieser, Jan L., Lin, I. I., Mears, Carl A., Liu, Gang, Li, Bailing, Liu, Hongxing, Locarnini, Ricardo, Loeb, Norman G., Long, Craig S., López, Luis A., Lorrey, Andrew M., Loyola, Diego, Lumpkin, Rick, Luo, Jing Jia, Luojus, K., Luthcke, S., Macias-Fauria, M., Malkova, G. V., Manney, Gloria L., Marcellin, Vernie, Marchenko, S. S., Marengo, José A., Marín, Dora, Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martin, A., Martínez, Alejandra G., Martínez-Güingla, Rodney, Martínez-Sánchez, Odalys, Marsh, Benjamin L., Lyman, John M., Massom, Robert A., May, Linda, Mayer, Michael, Mazloff, Matthew, McBride, Charlotte, McCabe, M. F., McCarthy, Mark, Meier, W., Meijers, Andrew J.S., Mekonnen, Ademe, Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Miller, Ben, Miralles, Diego G., Mitchum, Gary T., Mitro, Sukarni, Moat, Ben, Mochizuki, Y., Monselesan, Didier, Montzka, Stephen A., Mora, Natalie, Morice, Colin, Mosquera-Vásquez, Kobi, Mostafa, Awatif E., Mote, T., Mudryk, L., Mühle, Jens, Mullan, A. Brett, Müller, Rolf, Myneni, R., Nash, Eric R., Nerem, R. Steven, Newman, L., Newman, Paul A., Nielsen-Gammon, John W., Nieto, Juan José, Noetzli, Jeannette, Noll, Ben E., O'Neel, S., Osborn, Tim J., Osborne, Emily, Overland, J., Oyunjargal, Lamjav, Park, T., Pasch, Richard J., Pascual-Ramírez, Reynaldo, Pastor Saavedra, Maria Asuncion, Paterson, Andrew M., Paulik, Christoph, Pearce, Petra R., Peltier, Alexandre, Pelto, Mauri S., Peng, Liang, Perkins-Kirkpatrick, Sarah E., Perovich, Don, Petropavlovskikh, Irina, Pezza, Alexandre B., Phillips, C., Phillips, David, Phoenix, G., Pinty, Bernard, Pinzon, J., Po-Chedley, S., Polashenski, C., Purkey, Sarah G., Quispe, Nelson, Rajeevan, Madhavan, Rakotoarimalala, C., Rayner, Darren, Raynolds, M. K., Reagan, James, Reid, Phillip, Reimer, Christoph, Rémy, Samuel, Revadekar, Jayashree V., Richardson, A. D., Richter-Menge, Jacqueline, Ricker, R., Rimmer, Alon, Robinson, David A., Rodell, Matthew, Rodriguez Camino, Ernesto, Romanovsky, Vladimir E., Ronchail, Josyane, Rosenlof, Karen H., Rösner, Benjamin, Roth, Chris, Roth, David Mark, Rusak, James A., Rutishäuser, T., Sallée, Jean Bapiste, Sánchez-Lugo, Ahira, Santee, Michelle L., Sasgen, L., Sawaengphokhai, P., Sayad, T. A., Sayouri, Amal, Scambos, Ted A., Scanlon, T., Schenzinger, Verena, Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schreck, Carl J., Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Sharp, M., Shi, Lei, Shiklomanov, Nikolai I., Shimaraeva, Svetlana V., Siegel, David A., Silow, Eugene, Sima, Fatou, Simmons, Adrian J., Skirving, William J., Smeed, David A., Smeets, C. J.P.P., Smith, Adam, Smith, Sharon L., Soden, B., Sofieva, Viktoria, Sparks, T. H., Spence, Jacqueline M., Spillane, Sandra, Srivastava, A. K., Stackhouse, Paul W., Stammerjohn, Sharon, Stanitski, Diane M., Steinbrecht, Wolfgang, Stella, José L., Stengel, M., Stephenson, Kimberly, Stephenson, Tannecia S., Strahan, Susan, Streletskiy, Dimitri A., Strong, Alan E., Sun-Mack, Sunny, Sutton, Adrienne J., Swart, Sebastiaan, Sweet, William, Takahashi, Kenneth S., Tamar, Gerard, Taylor, Michael A., Tedesco, M., Thackeray, S. J., Thoman, R. L., Thompson, Philip, Thomson, L., Thorsteinsson, T., Timbal, Bertrand, Timmermans, M. L., TImofeyev, Maxim A., Tirak, Kyle V., Tobin, Skie, Togawa, H., Tømmervik, H., Tourpali, Kleareti, Trachte, Katja, Trewin, Blair C., Triñanes, Joaquin A., Trotman, Adrian R., Tschudi, M., Tucker, C. J., Tye, Mari R., Van As, D., Van De Wal, R. S.W., Van Der Ronald, J. A., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velden, Christopher S., Velicogna, I., Verburg, Piet, Vickers, H., Vincent, Lucie A., Vömel, Holger, Vose, Russell S., Wagner, Wolfgang, Walker, D. A., Walsh, J., Wang, Bin, Wang, Junhong, Wang, Lei, Wang, M., Wang, Ray, Wang, Sheng Hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Webster, M., Weller, Robert A., Westberry, Toby K., Weyhenmeyer, Gesa A., Whitewood, Robert, Widlansky, Matthew J., Wiese, David N., Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Willis, Josh K., Wolken, G., Wong, Takmeng, Wood, E. F., Wood, K., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yin, Xungang, Yoon, Huang, York, A., Yu, Lisan, Zambrano, Eduardo, Zhang, Huai Min, Zhang, Peiqun, Zhao, Guanguo, Zhao, Lin, Zhu, Zhiwei, Ziel, R., Ziemke, Jerry R., Ziese, Markus G., Griffin, Jessicca, Hammer, Gregory, Love-Brotak, S. Elizabeth, Misch, Deborah J., Riddle, Deborah B., Slagle, Mary, Sprain, Mara, Veasey, Sara W., and McVicar, Tim R.

Published
2018

17. Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

Author

Kim, Natalie, primary, Stiegler, Amy L., additional, Cameron, Thomas O., additional, Hallock, Peter T., additional, Gomez, Andrea M., additional, Huang, Julie H., additional, Hubbard, Stevan R., additional, Dustin, Michael L., additional, and Burden, Steven J., additional

Published
2008
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