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Simple Summary: The current prognostic index for chronic lymphocytic leukemia does not account for the dynamic changes in the B-cell clone over time. This study aims to investigate the association between the tumor microenvironment and the kinetics of clonal B-cells in early-stage CLL patients. By categorizing patients based on the rate of clonal B-cell increase, we identified significant differences in immune cell profiles and clinical outcomes. Patients with rapidly increasing clones exhibited poorer prognosis and shorter time to treatment, but notably, lower Tαβ CD4+CD8lo cell counts, altered B-cell subsets, and higher plasma cell counts were associated with highly proliferative clones. Multivariate analysis confirmed that the number of clonal B-cells, Tαβ CD4+CD8lo cells, and the IGHV mutational status were independent predictors of clonal expansion. These findings suggest that the interplay between CLL cells and the immune microenvironment might play a relevant role in disease progression, potentially leading to the development of novel prognostic markers. Background/Objectives: Despite the current international prognostic index for chronic lymphocytic leukemia (CLL) being widely accepted and broadly used, it does not consider the kinetics of the B-cell clone over time. Here, we investigated the potential association between distinct features of leukemic cells and other immune cells in blood and the kinetics of clonal B-cells in CLL stage Binet A/Rai 0 (A/0) patients; Methods: Based on the leukemia cell kinetics, 69 CLL A/0 cases followed for a median of 105 months were classified as carrying stable (n = 53) vs. rapidly increasing in size (n = 16) CLL clones; Results: Patients with increasing CLL clones had a significantly higher risk of disease progression and shortened time to first therapy vs. those carrying stable B-cell clones (p ≤ 0.001). Strikingly, the distribution of various immune-cell populations in blood at diagnosis also differed significantly between the two groups, with lower Tαβ CD4+CD8lo cell counts (p = 0.03), a greater switched/unswitched memory B-cell ratio (p = 0.01), and higher plasma cell counts (p = 0.05) in CLL with increasing vs. stable clones. Multivariate analysis revealed that the number of circulating clonal B-cells (≥15 × 109/L) and Tαβ CD4+CD8lo cells (≤35 cells/µL), together with an IGHV unmutated gene status at diagnosis, were independent predictors of an increasing CLL clone; Conclusions: Altogether, these data suggest that the expansion of the CLL clone in stage A/0 patients may depend on both the intrinsic characteristics of CLL cells and the surrounding immune microenvironment. [ABSTRACT FROM AUTHOR]

The number of foreign owners in football clubs has recently increased in Europe and especially in England. This study aims to analyze whether clubs owned by foreign investors show different parameters of sporting and managerial efficiency. We use data on expected performance (from betting odds), wage costs, and the results of football clubs in the English Premier League (EPL) and English Football League Championship (EFL) over 13 seasons. We estimate different measures of efficiency using three alternative methods: expected vs. actual performance index, nonparametric conditional data envelopment analysis (DEA), and stochastic frontier, while considering foreign ownership as an exogenous factor. Our results suggest that there are not significant differences between domestic- and foreign-owned clubs. [ABSTRACT FROM AUTHOR]

Empirical studies show that first- and second-generation immigrants are less likely to be members of sports clubs than their non-immigrant peers. Common explanations are cultural differences and socioeconomic disadvantages. However, lower participation rates in amateur sport could be at least partly due to ethnic discrimination. Are minority ethnic groups granted the same right to belong as their non-immigrant peers? To answer this question, this paper uses publicly available data from a field experiment in which mock applications were sent out to over 1,600 football clubs in Germany. Having a foreign-sounding name significantly reduces the likelihood of being invited to participate. The paper concludes that amateur football clubs are not as permeable as they are often perceived to be. It claims that traditional explanations for lower participation rates of immigrants need to be revisited. [ABSTRACT FROM AUTHOR]

This article describes the content published in the Journal of Sports Economics (JSE) for its 20th anniversary. The analysis focuses on the most relevant topics and captures the characteristics of authors, institutions, and types of collaborations over a 20-year period. In total, the sample includes 663 research articles (published from February 2000 to December 2019) and 856 authors from 490 institutions. The 20-year period offers an insightful picture of sports economics research. The article discusses additional features and trends and reflects on expected directions for future research in the journal. [ABSTRACT FROM AUTHOR]