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Background As treatment of coronary artery disease improved over the last years, management of elder patients remained a matter of debate since this age group has been underrepresented in most trials. The study aimed to evaluate a population of patients with ≥ 85 years old with non-ST-segment elevation myocardial infarction (NSTEMI) and compare the prognosis according to coronary revascularization execution. Methods We retrospectively studied 324 patients included in a national multicenter registry between October 2010 and October 2018, who underwent coronary angiography and had at least one stenosis ≥ 50%. Results In this population, 73.1% of the patients underwent percutaneous coronary intervention (PCI) and 26.9% of the patients underwent optimized medical treatment (OMT). The OMT group had more past history of diabetes, stroke and dementia. On coronary angiography, the PCI group used more often the femoral artery access and single-vessel lesions were also more common. Three-vessel disease was more common in the OMT group. During hospitalization, there were more major bleeding events and death in the PCI group. During the one-year follow-up, there were no significant differences in all-cause mortality rate. Conclusions Very old patients with NSTEMI submitted to OMT had more comorbidities and more three-vessel disease, factors that could have influenced the therapeutic decision. Patients undergoing PCI had more in-hospital major bleeding events and mortality, with no significant differences after one year.

We consider the initial-boundary value problem for a multidimensional linear parabolic PDE of second order. This problem is solvable in Holder spaces. The solution is numerically approximated, using finite differences, and the rate of convergence of the time-space finite difference scheme is estimated. Both explicit and implicit discrete operators are given. info:eu-repo/semantics/publishedVersion

In many cases, financial option pricing models give rise to PDEs which turn out to be very difficult to solve by classical analytic tools. In this article, we study the numerical approximation in space of the solution of the Cauchy problem for a multidimensional linear parabolic PDE of second order, with time and space-dependent coefficients. Making use of the L 2 theory of solvability in Sobolev spaces, the solution of the PDE problem is approximated in space, with finite-difference methods. The rate of convergence is estimated. info:eu-repo/semantics/publishedVersion

A presente investigação tem como objetivos: (i) a listagem exaustiva das rotas turísticas existentes em Portugal Continental; (ii) a identificação das suas formas de gestão e mecanismos de avaliação de "performance", tendo como critério o número de turistas que as fruem. Foi recolhida informação sobre as rotas existentes em Portugal Continental, através de consulta na internet e de contatos com o Turismo de Portugal, entidades regionais de turismo e câmaras municipais. Tendo-se constatado que uma grande diversidade de produtos turísticos eram indevidamente consideradas como rotas, tais como itinerários turísticos, percursos pedestres e outros, houve necessidade de estabelecer critérios rigorosos para inclusão nesta investigação. Depois deste levantamento, cada uma das entidades gestoras das rotas foi contactada através de email, sendo-lhes solicitado o preenchimento de um questionário previamente objecto de um estudo piloto. Foram recebidos 84 questionários preenchidos que respeitam o universo de rotas identificadas. Numa segunda fase de recolha de informação, procedemos a entrevistas semiestruturadas a especialistas de diversas entidades com vista a melhorar-se o entendimento da realidade objeto de investigação. Como resultados mais significativos das análises quantitativa e qualitativa efetuadas temos: (i) as rotas são maioritariamente de gestão por entidades públicas havendo, no entanto, algumas geridas por associações constituídas para o efeito; (ii) a maioria das rotas usa a internet para sua promoção, assim como folhetos; (iii) na sua maioria, as rotas não estão sinalizadas; (iv) apenas cerca de 60% das rotas procede à avaliação do número de visitantes; (v) o comportamento de avaliar o número de visitantes está associado dominantemente ao tipo de acesso organizado e à governança por uma estrutura de direção. Terminamos com algumas conclusões e recomendações, entre elas a de as rotas deverem ter uma entidade gestora, com participação de entidades públicas e privadas, e deverem ser certificadas e/ou terem acreditação, para sua valorização junto dos turistas. Propõe-se ainda a criação de uma Rede Nacional de Rotas Turísticas, que englobe todas as rotas certificadas e com divulgação num só sítio na Internet de todas as rotas existentes em Portugal. The present research aims to: (i) listing thoroughly the tourism routes existing in Mainland Portugal; (ii) identifying the managing structures and mechanics, and the performance evaluation procedures, using the number of visitors as the variable of interest. We collected information regarding the routes in Mainland Portugal by searching on the Internet and also by contacting the Turismo de Portugal, the regional tourism entities, and the municipal councils. Because the answers included a variety of products wrongly considered as routes, such as tour itineraries, walking tours, etc., there was the need to establish rogorous criteria for inclusion in the study. Next, each one of the route managing entities was contact by email, and asked to answer a previously tested questionnaire. 84 filled questionnaires were received, corresponding to the universe of the identified tourism routes. In a second stage, we conducted a number a semi-structured interviews with experts from several entities, with the purpose of improving the understanding of the object under study. As most relevant results of the quantitative and qualitative analyses, we have: (i) the routes are mostly managed by public entities, with some managed by associations built for the purpose; (ii) most of the routes use the Internet for advertising, as well as leaflets; (iii) most of the routes are signaled; (iv) only about 60% of the routes evaluate the number of visitors; (v) the evaluation behaviour is associated with the organised nature of the route access and governance by a direction board. We finish with some conclusions and recommendations, namely that the routes should have a dedicated managing body, with participation of public and private entities, and should be certified and/or to have accreditation, in order that their perceived value by the tourists is increased. We also propose the creation of a national tourist route network, including all certified routes and with advertising on a unique Internet site of all routes in the Country.