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Aim: The aim of this study was to draw a stomatological profile of elderly patients treated at the Stomatology Service of a referral hospital in the city of Belo Horizonte, Minas Gerais -- Brazil. Methods: Information was collected on the diagnostic hypotheses and definitive diagnoses of the elderly (aged 60 to 98 years) treated at the service, from September 2014 to December 2017. Results: Medical records of 1388 patients were evaluated, and 281 different diagnostic hypotheses were found. For males, there was a higher prevalence in both diagnostic and definitive diagnoses for benign and malignant epithelial neoplasms; In females, there was a higher prevalence, also in the hypotheses and diagnostic definitions, of inflammatory fibrous hyperplasia, related to the use of removable prostheses. Conclusion: Thus, this study evidenced the importance of knowledge about the main alterations that affect the oral cavity of elderly patients, which allows better attention to this population, besides being a pioneering stomatological study in hospital units. [ABSTRACT FROM AUTHOR]

Copyright of Archives of Dental Science / Arquivos em Odontologia is the property of Universidade Federal de Minas Gerais, Faculdade de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of Dental Science / Arquivos em Odontologia is the property of Universidade Federal de Minas Gerais, Faculdade de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of Dental Science / Arquivos em Odontologia is the property of Universidade Federal de Minas Gerais, Faculdade de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of Dental Science / Arquivos em Odontologia is the property of Universidade Federal de Minas Gerais, Faculdade de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Oral hairy leukoplakia is characterized by an asymptomatic white plaque on the lateral borders of the tongue. It is associated with immunodeficiency, principally to Human Immunodeficiency virus infection, but it has also been reported in patients with other immunosuppressed states. A 48- year-old man with primary amyloidosis was referred to evaluate a white plaque on the tongue. Based on the patient's clinical presentation, medical history, and localization of the oral lesion, differential clinical diagnosis included amyloidosis, oral hairy leukoplakia, idiopathic leukoplakia, hyperplastic chronic candidiasis, and uremic stomatitis. The diagnosis of oral hairy leukoplakia was confirmed by histopathological analysis and in situ hybridization showing Epstein-Barr virus. This is an unusual clinical presentation of oral hairy leukoplakia. [ABSTRACT FROM AUTHOR]

Graft-versus-host disease (GVHD) is associated with morbidity and mortality in the recipients of allogeneic hematopoietic stem cell transplants (allo-HSCTs). Interleukin-1β(IL-1β) is a potent inflammatory mediator involved in different inflammatory conditions. Therefore, we aimed to investigate the association of IL1B gene polymorphism in recipients and donors in cases in which acute GVHD (aGVHD) has been reported and the impact of this gene polymorphism on the level of cytokines in the blood and saliva. Fifty-eight consecutive allo- HSCT recipients and their donors were prospectively studied. Saliva and/or blood samples were obtained from the recipients and donors to identify the IL1B gene polymorphism, and cytokine levels were assessed by ELISA. Samples were collected weekly from 7 days before transplantation (day - 7) to 100 days after allo-HSCT (day + 100), for a total of 16 weeks or until death. aGVHD occurred in 27 individuals evaluated. A significant association was identified between the IL1B polymorphism in the donor and aGVHD development in the corresponding recipients. However, no significant association was detected between the IL1B polymorphism in recipients and the development of aGVHD. In the recipients who were diagnosed with aGVHD, the level of IL-1β in the saliva and blood were increased. In the saliva, IL-1β levels increased progressively from the time before the diagnosis of aGVHD until weeks after the diagnosis, whereas in the blood, IL-1β peak levels could be observed within the time allotted for diagnosis, followed by a decrease in the levels. In addition, we observed a significant association between the IL1B genotype of the recipient (CC) and high IL-1β levels in the saliva at week 13. In conclusion, IL-1β could be considered a useful predictor of aGVHD development. [ABSTRACT FROM AUTHOR]

Copyright of Pesquisa Brasileira em Odontopediatria e Clinica Integrada is the property of Pesquisa Brasileira em Odontopediatria e Clinica Integrada Journal (Brazil) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective. Interleukin-17 (IL-17) is a cytokine that induces neutrophil recruitment and the release of inflammatory mediators in several inflammatory conditions; nevertheless, the involvement of IL-17 gene polymorphisms in chronic periodontitis (CP) has not been addressed yet. Our aim was to evaluate the association between periodontal status and the polymorphisms IL-17A G197A and IL-17F C7488T in subjects with CP along with their impact on levels of inflammatory mediators. Material and Methods. Genomic DNA was obtained from 30 CP patients and 30 healthy controls (HCs). IL-17A G197A and IL-17F C7488T polymorphisms were determined using PCR-RFLP. Serum and periodontal tissues were collected and processed for ELISA, myeloperoxidase (MPO), and/or microscopic analysis. Results. The frequencies of genotypes in the CP group were significantly different from those of HC. Odds ratio indicated that increased risks for CP were associated with the -197A allele, not with the -7488T allele. In addition, the -197A allele was correlated with worse clinical parameters, higher MPO activity, and increased expression of inflammatory mediators (IL-17A and IL-8) than the other genotypes. Conclusions. These results indicate that the IL-17A -197A allele is associated with increased risk for CP, likely because this genotype relates to the enhanced inflammation in periodontal tissues. [ABSTRACT FROM AUTHOR]