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Prins reaction is a very useful and important reaction in the field of synthetic organic chemistry. Prins cyclization is one of the greatest significant synthetic approaches in the total synthesis of various natural compounds especially pyran and furan units. The addition of aldehydes to olefinic compounds utilizing acid catalyst has become important for the industry. : Aldehydes and alkenes to give different products depending on the reaction conditions, yield an acidcatalyzed reaction. Formation of Carbon-Carbon bonds is useful to produce 1,3-diol, 1,3-dioxane, β- halohydrin and allylic alcohols and tetrahydropyrans by using this methodology. Now coming to the point of tandem Prins cyclization, this method is very useful for the synthesis of fused compounds and also for the construction of spirocyclic compounds such as tetrahydropyrans or furans. The present brief review mainly deals with the development of the synthesis of oxygen-containing heterocyclic compounds by using prins/tandem prins cyclization. This current review is focused mainly on tandem prins cyclization’s reactions for the particular recent applications and what methods are used for the construction of the oxygen contained heterocyclic compounds.

India has been facing many problems in recent times due to pandemic Covid-19, pollution, population and also many other natural disasters. In addition to these problems, the country is also facing some tragedies such as leakage of gases from industries and blasts. Many gas leakages and blasts were seen in India from the last few decades. Recently, the Visakhapatnam in Andhra Pradesh, India also experienced a gas leakage into atmosphere, which is a dangerous chemical gas i.e styrene from Polymer Company named LG polymer India Company limited on May 7th 2020. LG polymers manufacture plastics and expandable plastics using styrene monomer as raw material. Many people were affected and died due to this leakage of dangerous chemical gas which was released from the polymer industry at early hours of morning. The gas leakage has spread to many nearby villages and has spread to many kilometres. Mainly respiratory problems, eye irritation and skin irritation are the symptoms of the exposure to styrene. Long exposure to this chemical gas may cause the respiratory diseases that effect during lifetime. There should be some environmental measurements and remedies should be taken by government and also by the people in order to overcome these types of situations.