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2. National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities

Author

Kim, Michelle M, Mehta, Minesh P, Smart, DeeDee K, Steeg, Patricia S, Hong, Julie A, Espey, Michael G, Prasanna, Pataje G, Crandon, Laura, Hodgdon, Christine, Kozak, Niki, Armstrong, Terri S, Morikawa, Aki, Willmarth, Nicole, Tanner, Kirk, Boire, Adrienne, Gephart, Melanie Hayden, Margolin, Kim A, Hattangadi-Gluth, Jona, Tawbi, Hussein, Trifiletti, Daniel M, Chung, Caroline, Basu-Roy, Upal, Burns, Robyn, Oliva, Isabella C Glitza, Aizer, Ayal A, Anders, Carey K, Davis, Joanne, Ahluwalia, Manmeet S, Chiang, Veronica, Li, Jing, Kotecha, Rupesh, Formenti, Silvia C, Ellingson, Benjamin M, Gondi, Vinai, Sperduto, Paul W, Barnholtz-Sloan, Jill S, Rodon, Jordi, Lee, Eudocia Q, Khasraw, Mustafa, Yeboa, Debra Nana, Brastianos, Priscilla K, Galanis, Evanthia, Coleman, C Norman, and Ahmed, Mansoor M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Neurosciences, Good Health and Well Being, United States, Humans, Quality of Life, National Cancer Institute (U.S.), Biomedical Research, Consensus, Brain Neoplasms, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Brain metastases are an increasing global public health concern, even as survival rates improve for patients with metastatic disease. Both metastases and the sequelae of their treatment are key determinants of the inter-related priorities of patient survival, function, and quality of life, mandating a multidimensional approach to clinical care and research. At a virtual National Cancer Institute Workshop in September, 2022, key stakeholders convened to define research priorities to address the crucial areas of unmet need for patients with brain metastases to achieve meaningful advances in patient outcomes. This Policy Review outlines existing knowledge gaps, collaborative opportunities, and specific recommendations regarding consensus priorities and future directions in brain metastases research. Achieving major advances in research will require enhanced coordination between the ongoing efforts of individual organisations and consortia. Importantly, the continual and active engagement of patients and patient advocates will be necessary to ensure that the directionality of all efforts reflects what is most meaningful in the context of patient care.

Published
2023

3. Proceedings of the Survivorship Care in Neuro-Oncology Workshop sponsored by the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT).

Author

Leeper, Heather E, Tonorezos, Emily, Mayer, Deborah, Bakitas, Marie, Chang, Susan, Cooley, Mary E, Hervey-Jumper, Shawn, Miaskowski, Christine, Sherwood, Paula, Tsien, Christina, Wallgren, Kimberly, Willmarth, Nicole, Arons, David, Acquaye, Alvina, King, Amanda L, Penas-Prado, Marta, Vera, Elizabeth, Gilbert, Mark R, Armstrong, Terri S, Arzbaecher, Jean, Dionne-Odom, J Nicholas, Fink, Karen, Hayes, Christi, Leeper, Heather, Lollo, Nicole, Loughan, Ashlee, Oliver, Kathy, Roche, Kayla, Stearn, Sylvia, Timmer, Michael, Amidei, Christina, Blakeley, Jaishri, Cachia, David, Cooke, Laura, Cooley, Mary, Gondi, Vinai, Leach, Danielle, Mendoza, Tito, Morgan, Kendall, Nabors, Burt, Naines, Kristie, Rogers, James, Sharma, Akanksha, Wall, Kathleen, Weathers, Shiao-Pei, Wollet, Alex, Boccia, Maria, Camphausen, Kevin, Christ, Alexa, Figuracion, Karl Cristie, Gilbert, Mark, Komlodi-Pasztor, Edina, Lieberman, Frank, Malkin, Mark, Miller, Hope, Paleologos, Nina, Panzer, Marissa, Stout, Nicole, Wen, Patrick, Beam, Sarah, Boris, Lisa, Fonkem, Ekokobe, Jammula, Varna, Kauss, McKenzie, Kim, Yeonju, Ozer, Byram H, Pan, Edward, Pugh, Stephanie, Strowd, Roy, Wu, Jing, Zaghloul, Kareem, Bell, Susan, Dunbar, Erin M, Haynes, Chas, Haynes, Tuesday, Lesser, Glenn, Maher, Molly, Polskin, Lily, and Pillai, Tina

Subjects
Cancer, Clinical Research, Neurosciences, Management of diseases and conditions, 7.1 Individual care needs, Good Health and Well Being, NCI-CONNECT, patient-centered care, primary central nervous system cancer, survivorship, survivorship care, NCI-CONNECT Survivorship Care in Neuro-Oncology Workshop
Abstract

BackgroundSurvivorship for those living with primary CNS cancers begins at diagnosis, continues throughout a person's life, and includes caregivers. Opportunities and challenges exist to advance survivorship care for those living with primary CNS cancers that necessitate stakeholder involvement.MethodsIn June 2021, NCI-CONNECT convened a two-day virtual workshop about survivorship care in neuro-oncology. Two expert panels provided key recommendations and five working groups considered critical questions to identify strengths, weaknesses, opportunities, and threats to the advancement of survivorship care and developed recommendations and action items.ResultsThe following action items emanated from the workshop: seek endorsement of meeting report from stakeholder organizations; address barriers in access to survivorship care and provider reimbursement; advance survivorship research through NIH and private grant support; develop a survivorship tool kit for providers, people living with primary CNS cancers and their caregivers; provide accessible educational content for neuro-oncology, neurology, and oncology community providers about survivorship care in neuro-oncology; and establish core competencies for survivorship care for neuro-oncology providers to be included in training and standardized exams.ConclusionsAction items aim to address access and reimbursement barriers, expand patient and provider education, develop core competencies, and support survivorship research through funding and other supports.

Published
2022

7. Association of Pretreatment Hippocampal Volume With Neurocognitive Function in Patients Treated With Hippocampal Avoidance Whole Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology/RTOG 0933

Author

Abraham, Christopher D., Pugh, Stephanie L., Bovi, Joseph A., Gondi, Vinai, Mehta, Minesh P., Benzinger, Tammie, Owen, Christopher J., Lo, Simon S., Kundapur, Vijayananda, Brown, Paul D., Sun, Alexander Y., Howard, Steven P., DeNittis, Albert S., Robinson, Clifford G., and Kachnic, Lisa A.

Published
2022
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8. Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline

Author

Gondi, Vinai, Bauman, Glenn, Bradfield, Lisa, Burri, Stuart H., Cabrera, Alvin R., Cunningham, Danielle A., Eaton, Bree R., Hattangadi‐Gluth, Jona A., Kim, Michelle M., Kotecha, Rupesh, Kraemer, Lianne, Li, Jing, Nagpal, Seema, Rusthoven, Chad G., Suh, John H., Tomé, Wolfgang A., Wang, Tony J.C., Zimmer, Alexandra S., Ziu, Mateo, and Brown, Paul D.

Published
2022
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9. National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury.

Author

Haas-Kogan, Daphne, Indelicato, Daniel, Paganetti, Harald, Esiashvili, Natia, Mahajan, Anita, Yock, Torunn, Flampouri, Stella, MacDonald, Shannon, Fouladi, Maryam, Stephen, Kry, Kalapurakal, John, Terezakis, Stephanie, Kooy, Hanne, Grosshans, David, Makrigiorgos, Mike, Mishra, Kavita, Poussaint, Tina, Cohen, Kenneth, Fitzgerald, Thomas, Gondi, Vinai, Liu, Arthur, Michalski, Jeff, Mirkovic, Dragan, Mohan, Radhe, Perkins, Stephanie, Wong, Kenneth, Vikram, Bhadrasain, Buchsbaum, Jeff, and Kun, Larry

Subjects
Brain Stem, Cancer Care Facilities, Child, Florida, Humans, Infratentorial Neoplasms, Linear Energy Transfer, Massachusetts, National Cancer Institute (U.S.), Necrosis, Photons, Practice Guidelines as Topic, Proton Therapy, Radiation Injuries, Radiotherapy, Intensity-Modulated, Relative Biological Effectiveness, Texas, Uncertainty, United States
Abstract

PURPOSE: Proton therapy can allow for superior avoidance of normal tissues. A widespread consensus has been reached that proton therapy should be used for patients with curable pediatric brain tumor to avoid critical central nervous system structures. Brainstem necrosis is a potentially devastating, but rare, complication of radiation. Recent reports of brainstem necrosis after proton therapy have raised concerns over the potential biological differences among radiation modalities. We have summarized findings from the National Cancer Institute Workshop on Proton Therapy for Children convened in May 2016 to examine brainstem injury. METHODS AND MATERIALS: Twenty-seven physicians, physicists, and researchers from 17 institutions with expertise met to discuss this issue. The definition of brainstem injury, imaging of this entity, clinical experience with photons and photons, and potential biological differences among these radiation modalities were thoroughly discussed and reviewed. The 3 largest US pediatric proton therapy centers collectively summarized the incidence of symptomatic brainstem injury and physics details (planning, dosimetry, delivery) for 671 children with focal posterior fossa tumors treated with protons from 2006 to 2016. RESULTS: The average rate of symptomatic brainstem toxicity from the 3 largest US pediatric proton centers was 2.38%. The actuarial rate of grade ≥2 brainstem toxicity was successfully reduced from 12.7% to 0% at 1 center after adopting modified radiation guidelines. Guidelines for treatment planning and current consensus brainstem constraints for proton therapy are presented. The current knowledge regarding linear energy transfer (LET) and its relationship to relative biological effectiveness (RBE) are defined. We review the current state of LET-based planning. CONCLUSIONS: Brainstem injury is a rare complication of radiation therapy for both photons and protons. Substantial dosimetric data have been collected for brainstem injury after proton therapy, and established guidelines to allow for safe delivery of proton radiation have been defined. Increased capability exists to incorporate LET optimization; however, further research is needed to fully explore the capabilities of LET- and RBE-based planning.

Published
2018

12. Results from METIS (EF-25), an international, multicenter phase III randomized study evaluating the efficacy and safety of tumor treating fields (TTFields) therapy in NSCLC patients with brain metastases.

Author

Mehta, Minesh P., primary, Gondi, Vinai, additional, Ahluwalia, Manmeet Singh, additional, Roberge, David, additional, Ilic, Rosanda, additional, Sio, Terence Tai Weng, additional, Trifiletti, Daniel Michael, additional, Muanza, Thierry, additional, Krpan, Ana Misir, additional, Ramakrishna, Naren R, additional, Fiveash, John B., additional, Metellus, Philippe, additional, Wang, Chiachien Jake, additional, Feuvret, Loïc, additional, Freyschlag, Christian, additional, Csőszi, Tibor, additional, Brown, Paul D., additional, and Harat, Maciej, additional

Published
2024
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13. Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach

Author

Wang, Du, primary, Geng, Huaizhi, additional, Gondi, Vinai, additional, Lee, Nancy Y., additional, Tsien, Christina I., additional, Xia, Ping, additional, Chenevert, Thomas L., additional, Michalski, Jeff M., additional, Gilbert, Mark R., additional, Le, Quynh-Thu, additional, Omuro, Antonio M., additional, Men, Kuo, additional, Aldape, Kenneth D., additional, Cao, Yue, additional, Srinivasan, Ashok, additional, Barani, Igor J., additional, Sachdev, Sean, additional, Huang, Jiayi, additional, Choi, Serah, additional, Shi, Wenyin, additional, Battiste, James D., additional, Wardak, Zabi, additional, Chan, Michael D., additional, Mehta, Minesh P., additional, and Xiao, Ying, additional

Published
2024
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14. Dose-escalated accelerated hypofractionation for elderly or frail patients with a newly diagnosed glioblastoma

Author

Perlow, Haley K., Yaney, Alexander, Yang, Michael, Klamer, Brett, Matsui, Jennifer, Raval, Raju R., Blakaj, Dukagjin M., Arnett, Andrea, Beyer, Sasha, Elder, James B., Ammirati, Mario, Lonser, Russell, Hardesty, Douglas, Ong, Shirley, Giglio, Pierre, Pillainayagam, Clement, Goranovich, Justin, Grecula, John, Chakravarti, Arnab, Gondi, Vinai, Brown, Paul D., and Palmer, Joshua D.

Published
2022
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18. Role of Whole-Brain Radiotherapy

Author

Lynch, Connor, Gross, Jeffrey P., Gondi, Vinai, Ramakrishna, Rohan, editor, Magge, Rajiv S., editor, Baaj, Ali A., editor, and Knisely, Jonathan P.S., editor

Published
2020
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20. A Multi-institutional Phase I Study of Acetazolamide with Temozolomide in Adults with Newly Diagnosed MGMT-methylated Malignant Glioma

Author

Driscoll, Riley K, primary, Lyne, Sean B, additional, Voce, David J, additional, Maraka, Stefania, additional, Gondi, Vinai, additional, Chmura, Steven J, additional, Dixit, Karan S, additional, Kumthekar, Priya U, additional, Karrison, Theodore G, additional, Pytel, Peter, additional, Collins, John M, additional, Stupp, Roger, additional, Merrell, Ryan T, additional, Lukas, Rimas V, additional, and Yamini, Bakhtiar, additional

Published
2024
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22. Pretreatment Volume of MRI-Determined White Matter Injury Predicts Neurocognitive Decline After Hippocampal Avoidant Whole-Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology Radiation Therapy Oncology Group 0933

Author

Bovi, Joseph A., Pugh, Stephanie L., Sabsevitz, David, Robinson, Clifford G., Paulson, Eric, Mehta, Minesh P., Gondi, Vinai, Kundapur, Vijayananda, Shahin, Mark S., Chao, Samuel T., Machtay, Mitch, DeNittis, Albert S., Laack, Nadia N., Greenspoon, Jeffrey N., Moore, Kathleen N., Huang, Jiayi, Dominello, Michael M., and Kachnic, Lisa A.

Published
2019
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23. Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001.

Author

Cherng, Hua-Ren R, Qu, Melody, Zafari, Zafar, Bentzen, Søren M, Armstrong, Terri S, Gondi, Vinai, Brown, Paul D, Mehta, Minesh, and Mishra, Mark V

Subjects
SECONDARY analysis, QUALITY of life, VISUAL analog scale, BRAIN tumors
Abstract

Background EuroQoL EQ-5D-5L is a commonly used measure of health-related quality of life in clinical trials given the use of its index score as a measure of health utilities. It is unclear whether EQ-5D-5L is sensitive to changes in neurocognitive function and progression that occur following brain radiation. This study sought to evaluate the sensitivity of EQ-5D-5L in reflecting these changes. Methods A secondary analysis of NRG Oncology CC001 was performed. Mean EQ-5D-5L index and visual analog scale (VAS) score changes from baseline between groups of patients stratified by neurocognitive function and intracranial progression status were assessed. MD Anderson Symptom Inventory for brain tumor (MDASI-BT) symptom and interference items were also analyzed between groups. Results EQ-5D-5L mean index and VAS score changes between patients who had cognitive failure and those who had preserved cognition showed no statistically significant differences at any timepoint. In contrast, VAS changes at 4 months (1.61 vs -5.13, P  = .05) and 6 months (8.17 vs −0.14, P  = .04) were significantly improved in the patients who survived without intracranial progression. MDASI-BT cognitive factor scores were improved in the cohort of patients with preserved neurocognitive function at 2 months (1.68 vs 2.08, P  = .05) and 4 months (1.35 vs 1.83, P  = .04). MDASI-BT symptom interference was significantly associated with intracranial progression at 4 months, but not with neurocognitive status. Conclusion EQ-5D-5L index and VAS scores were not sensitive to neurocognitive changes that patients experienced, but VAS scores were sensitive to progression. This study challenges the routine use of EQ-5D as a quality of life metric in brain metastases clinical trials that are focused on preventing neurocognitive dysfunction. Trial Registration NCT# 02360215. [ABSTRACT FROM AUTHOR]

Published
2024
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26. BIOM-03. LACK OF CORRELATION OF MR-DETERMINED WHITE MATTER INJURY(WMI)WITH NEUROCOGNITIVE FUNCTION (NCF)6 MONTHS FOLLOWING WBRT+/-HIPPOCAMPAL AVOIDANCE(HA)+MEMANTINE:SECONDARY ANALYSIS OF NRG ONCOLOGY NRGCC001

Author

Bovi, Joseph, primary, Pugh, Stephanie, additional, Brown, Paul, additional, Gondi, Vinai, additional, Robinson, Clifford, additional, Wefel, Jeffrey, additional, Sabsevitz, David, additional, Sprenger, Markus, additional, Kundapur, Vijayananda, additional, Roberge, David, additional, Devisetty, Kiran, additional, Shah, Sunjay, additional, Usuki, Kenneth, additional, Stea, Baldassarre, additional, Yoon, Harold, additional, Donnelly, Eric, additional, Laack, Nadia, additional, Baschnagel, Andrew, additional, Paulus, Rebecca, additional, and Kachnic, Lisa, additional

Published
2023
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27. RADT-01. BASELINE HIPPOCAMPAL VOLUME AS A PREDICTOR OF NEUROCOGNITIVE CHANGES AFTER WBRT OR HA-WBRT: SECONDARY ANALYSIS OF NRG ONCOLOGY CC001

Author

Abraham, Christopher, primary, Pugh, Stephanie, additional, Brown, Paul, additional, Gondi, Vinai, additional, Bovi, Joseph, additional, Robinson, Clifford, additional, Wefel, Jeffrey, additional, Roberge, David, additional, Kundapur, Vijayananda, additional, Devisetty, Kiran, additional, Shah, Sunjay, additional, Usuki, Kenneth, additional, Baschnagel, Andrew, additional, Stea, Baldassarre, additional, Yoon, Harold, additional, Li, Jing, additional, Laack, Nadia, additional, Jindal, Saurahb, additional, Borges, Monica, additional, and Kachnic, Lisa, additional

Published
2023
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28. CTIM-18. NRG ONCOLOGY STUDY BN007: RANDOMIZED PHASE II/III TRIAL OF IPILIMIUMAB (IPI) PLUS NIVOLUMAB (NIVO) VS. TEMOZOLOMIDE (TMZ) IN MGMT-UNMETHYLATED (UMGMT) NEWLY DIAGNOSED GLIOBLASTOMA (NGBM)

Author

Lassman, Andrew, primary, Polly, Mei-Yin, additional, Iwamoto, Fabio, additional, Sloan, Andrew, additional, Wang, Tony, additional, Aldape, Kenneth, additional, Wefel, Jeffrey, additional, Gondi, Vinai, additional, Gutierrez, Alonson, additional, Manasawala, Mohammed, additional, Gilbert, Mark, additional, Sulman, Erik, additional, Wolchok, Jedd, additional, Green, Richard, additional, Neil, Elizabeth, additional, Lukas, Rimas, additional, Goldlust, Samuel, additional, Snuderl, Matija, additional, Dignam, James, additional, Won, Minhee, additional, Movsas, Benjamin, additional, and Mehta, Minesh, additional

Published
2023
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29. Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001

Author

Gondi, Vinai, primary, Deshmukh, Snehal, additional, Brown, Paul D., additional, Wefel, Jeffrey S., additional, Armstrong, Terri S., additional, Tome, Wolfgang A., additional, Gilbert, Mark R., additional, Konski, Andre, additional, Robinson, Clifford G., additional, Bovi, Joseph A., additional, Benzinger, Tammie L.S., additional, Roberge, David, additional, Kundapur, Vijayananda, additional, Kaufman, Isaac, additional, Shah, Sunjay, additional, Usuki, Kenneth Y., additional, Baschnagel, Andrew M., additional, Mehta, Minesh P., additional, and Kachnic, Lisa A., additional

Published
2023
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37. Deep Learning-Based Automatic Detection of Brain Metastases in Heterogenous Multi-Institutional Magnetic Resonance Imaging Sets: An Exploratory Analysis of NRG-CC001

Author

Liang, Ying, primary, Lee, Karen, additional, Bovi, Joseph A., additional, Palmer, Joshua D., additional, Brown, Paul D., additional, Gondi, Vinai, additional, Tomé, Wolfgang A., additional, Benzinger, Tammie L.S., additional, Mehta, Minesh P., additional, and Li, X. Allen, additional

Published
2022
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38. NCOG-03. IMPACT OF THE RATE OF RADIOGRAPHIC RESPONSE (RR) OF BRAIN METASTASES (BM) TO WHOLE BRAIN RADIATION THERAPY (WBRT) ON NEUROCOGNITIVE FUNCTION (NCF) ON NRG-CC001

Author

Devisetty, Kiran, primary, Pugh, Stephanie, additional, Brown, Paul, additional, Gondi, Vinai, additional, Wefel, Jeffrey, additional, Solanki, Abhishek, additional, Kalapparambath, Tomy, additional, Harmon, Grant, additional, Saripalli, Anjali, additional, Chou, Brian, additional, Venkatesulu, Bhanu Prasad, additional, Boike, Thomas, additional, Kundapur, Vijayananda, additional, Roberge, David, additional, Bovi, Joseph, additional, McGee, Mackenzie, additional, Kruser, Tim, additional, Baschnagel, Andrew, additional, Usuki, Kenneth, additional, Mehta, Minesh, additional, and Kachnic, Lisa, additional

Published
2022
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39. CTNI-49. EARLY SIGNAL OF ACTIVITY FROM A PHASE 2 STUDY OF ST101, A FIRST-IN-CLASS PEPTIDE ANTAGONIST OF CCAAT/ENHANCER-BINDING PROTEIN Β (C/EBPΒ), IN RECURRENT GLIOBLASTOMA (GBM)

Author

Iwamoto, Fabio, primary, Gondi, Vinai, additional, Butowski, Nicholas, additional, Falchook, Gerald, additional, Williams, Anja, additional, Peters, Katherine B, additional, Evans, Jeff, additional, Lakhani, Nehal, additional, McKean, Meredith, additional, Symeonides, Stefan, additional, Ellingson, Benjamin, additional, Rotolo, Jim, additional, Capiaux, Gina, additional, Wiegert, Erol, additional, Michel, Rob, additional, Kaesshaefer, Steve, additional, and Bexon, Alice, additional

Published
2022
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43. Assembling the brain trust: the multidisciplinary imperative in neuro-oncology

Author

Ludmir, Ethan B., Mahajan, Anita, Ahern, Verity, Ajithkumar, Thankamma, Alapetite, Claire, Bernier-Chastagner, Valérie, Bindra, Ranjit S., Bishop, Andrew J., Bolle, Stephanie, Brown, Paul D., Carrie, Christian, Chalmers, Anthony J., Chang, Eric L., Chung, Caroline, Dieckmann, Karin, Esiashvili, Natia, Gandola, Lorenza, Ghia, Amol J., Gondi, Vinai, Grosshans, David R., Harrabi, Semi B., Horan, Gail, Indelicato, Danny J., Jalali, Rakesh, Janssens, Geert O., Krause, Mechthild, Laack, Nadia N., Laperriere, Normand, Laprie, Anne, Li, Jing, Marcus, Karen J., McGovern, Susan L., Merchant, Thomas E., Merrell, Kenneth W., Padovani, Laetitia, Parkes, Jeannette, Paulino, Arnold C., Schwarz, Rudolf, Shih, Helen A., Souhami, Luis, Sulman, Erik P., Taylor, Roger E., Thorp, Nicola, Timmermann, Beate, Wheeler, Greg, Wolden, Suzanne L., Woodhouse, Kristina D., Yeboa, Debra N., Yock, Torunn I., Kortmann, Rolf-Dieter, and McAleer, Mary Frances

Published
2019
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44. Primary Central Nervous System Lymphoma: PART 1: Epidemiology, Diagnosis, Staging, and Prognosis

Author

Lukas, Rimas V., Stupp, Roger, Gondi, Vinai, and Raizer, Jeffrey J.

Subjects
Lymphomas -- Diagnosis -- Demographic aspects, Central nervous system diseases -- Diagnosis -- Demographic aspects, Health
Abstract

Primary central nervous system (CNS) lymphoma is a rare CNS neoplasm. Its highest incidence is in the elderly and the immunocompromised. The initial steps in establishing a diagnosis involve CNS imaging. Familiarity with the clinical presentation is important in order to limit the risk of a nondiagnostic biopsy. In addition to confirming the diagnosis, it is wise to evaluate for extra-CNS disease. There are important differences in the presentation and evaluation of immunocompetent patients and those of immunocompromised patients; we will delineate these in this review. Appropriate initial clinical evaluations facilitate optimal therapeutic management for patients with primary CNS lymphoma. This is of particular importance because primary CNS lymphoma is a potentially curable disease, despite the high likelihood of recurrence., Introduction Primary central nervous system (CNS) lymphoma is a rare and aggressive CNS neoplasm with a high morbidity and often fatal outcome. However, many patients may be cured. Diagnostic pitfalls [...]

Published
2018

45. Radiotherapy for elderly patients with glioblastoma: an assessment of hypofractionation and modern treatment techniques

Author

Matsui, Jennifer K., primary, Perlow, Haley K., additional, Facer, Benjin D., additional, McCalla, Aliah, additional, Marrazzo, Livia, additional, Detti, Beatrice, additional, Scorsetti, Marta, additional, Clerici, Elena, additional, Scoccianti, Silvia, additional, Navarria, Pierina, additional, Trifiletti, Daniel M., additional, Gondi, Vinai, additional, Bovi, Joseph, additional, Huang, Jiayi, additional, Brown, Paul D., additional, and Palmer, Joshua D., additional

Published
2022
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46. Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic

Author

Matsui, Jennifer K., primary, Perlow, Haley K., additional, Baiyee, Cyril, additional, Ritter, Alex R., additional, Mishra, Mark V., additional, Bovi, Joseph A., additional, Gondi, Vinai, additional, Brown, Paul D., additional, Loughan, Ashlee R., additional, Leeper, Heather E., additional, Dawson, Erica, additional, and Palmer, Joshua D., additional

Published
2022
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47. SPCR-01 RAPIDPLAN HIPPOCAMPAL SPARING WHOLE BRAIN MODEL VERSION 2 - HOW FAR CAN WE REDUCE THE DOSE?

Author

Liu, Hefei, primary, Clark, Ryan, additional, Magliari, Anthony, additional, Foster, Robert, additional, Reynoso, Francisco, additional, Schmidt, Matthew, additional, Gondi, Vinai, additional, Abraham, Christopher, additional, Curry, Heather, additional, Kupelian, Patrick, additional, Khuntia, Deepak, additional, and Beriwal, Sushil, additional

Published
2022
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50. Radiation Therapy for Brain Metastases: ASCO Guideline Endorsement of ASTRO Guideline

Author

Schiff, David, primary, Messersmith, Hans, additional, Brastianos, Priscilla K., additional, Brown, Paul D., additional, Burri, Stuart, additional, Dunn, Ian F., additional, Gaspar, Laurie E., additional, Gondi, Vinai, additional, Jordan, Justin T., additional, Maues, Julia, additional, Mohile, Nimish, additional, Redjal, Navid, additional, Stevens, Glen H.J., additional, Sulman, Erik P., additional, van den Bent, Martin, additional, Wallace, H. James, additional, Zadeh, Gelareh, additional, and Vogelbaum, Michael A., additional

Published
2022
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