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6. GENETICS: ASSOCIATION OF GENETIC VARIATION OF TOMM40 WITH COGNITIVE DECLINE IN OLDER ADULTS: THE SONIC STUDY

Author

Ryuno, H., Kamide, K., Kabayama, M., Sugimoto, K., Ishizaki, T., Arai, Y., Gondo, Y., and Rakugi, H.

Subjects
Abstracts
Abstract

Background: It is reported that single nucleotide polymorphism (SNP) of the Translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene is significantly associated with late-onset Alzheimer’s disease and cognitive decline in various ethnic groups. The aim of this study is to clarify the association of rs2075650 in TOMM40 with cognitive function among 70- and 80-year-old Japanese general population.

Published
2017

7. Caregiving centenarians: Cross-national comparison in Caregiver-Burden between the United States and Japan.

Author

Cho, J., Nakagawa, T., Martin, P., Gondo, Y., Poon, L. W., and Hirose, N.

Subjects
GERIATRIC assessment, CENTENARIANS, MULTIVARIATE analysis, PERSONALITY assessment, POPULATION geography, VISION disorders, ETHNOLOGY research, MULTIPLE regression analysis, BURDEN of care, DESCRIPTIVE statistics
Abstract

Background and Objectives: The personal distress associated with caring for a family member has been well documented; however, questions about the burden of caregiving for centenarians and cross-national differences in the caregiving context, remain unanswered. Research Design and Methods: This study includes reports by caregivers of 538 near-centenarians and centenarians in the U.S. and Japan: 234 from the Georgia Centenarian Study and 304 from the Tokyo Centenarian Study. Basic descriptive and multivariate regression analyses were conducted. Mean levels of caregiver burden and near-centenarian and centenarians' characteristics (as predictors) for caregiver burden were compared between the U.S. and Japan. The near-centenarian and centenarians' functional capacity and personality were assessed as predictors. Results: Differential predictive patterns in caregiver burden were found in the two groups. In the U.S., near-centenarian and centenarians' agreeableness and conscientiousness were negatively associated with caregiver burden; whereas the near-centenarian and centenarians' neuroticism and number of diseases were positively associated with caregiver burden. In Japan, the near-centenarian and centenarians' activities of daily living, openness, and agreeableness were negatively associated with caregiving burden. Interaction effects between functional capacity and personality, on caregiver burden were observed only in the U.S. In the U.S., higher levels of agreeableness and openness significantly changed the level of caregiver burden associated with vision problems and a greater number of diseases. Discussion and Implications: Cross-national comparative predictors of caregiving burden between the two countries emphasized that caring for centenarians should be understood in the caregiving context, as well as the social context. [ABSTRACT FROM AUTHOR]

Published
2020
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18. GENETICS

Author

Ryuno, H., primary, Kamide, K., additional, Kabayama, M., additional, Sugimoto, K., additional, Ishizaki, T., additional, Arai, Y., additional, Gondo, Y., additional, and Rakugi, H., additional

Published
2017
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23. Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial

Author

Takada, M., primary, Nishida, K., additional, Gondo, Y., additional, Kikuchi-Hayakawa, H., additional, Ishikawa, H., additional, Suda, K., additional, Kawai, M., additional, Hoshi, R., additional, Kuwano, Y., additional, Miyazaki, K., additional, and Rokutan, K., additional

Published
2017
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24. ICC-dementia (International Centenarian Consortium - dementia): An international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups

Author

Brodaty, H, Woolf, C, Andersen, S, Barzilai, N, Brayne, C, Cheung, KSL, Corrada, MM, Crawford, JD, Daly, C, Gondo, Y, Hagberg, B, Hirose, N, Holstege, H, Kawas, C, Kaye, J, Kochan, NA, Lau, BHP, Lucca, U, Marcon, G, Martin, P, Poon, LW, Richmond, R, Robine, JM, Skoog, I, Slavin, MJ, Szewieczek, J, Tettamanti, M, Viña, J, Perls, T, Sachdev, PS, Brodaty, H, Woolf, C, Andersen, S, Barzilai, N, Brayne, C, Cheung, KSL, Corrada, MM, Crawford, JD, Daly, C, Gondo, Y, Hagberg, B, Hirose, N, Holstege, H, Kawas, C, Kaye, J, Kochan, NA, Lau, BHP, Lucca, U, Marcon, G, Martin, P, Poon, LW, Richmond, R, Robine, JM, Skoog, I, Slavin, MJ, Szewieczek, J, Tettamanti, M, Viña, J, Perls, T, and Sachdev, PS

Abstract

Background: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. Methods: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. Discussion: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisa

Published
2016

26. Dietary Intake Is Associated with Occlusal Force Rather Than Number of Teeth in 80-y-Old Japanese

Author

Inomata, C., primary, Ikebe, K., additional, Okubo, H., additional, Takeshita, H., additional, Mihara, Y., additional, Hatta, K., additional, Tada, S., additional, Enoki, K., additional, Ogawa, T., additional, Matsuda, K., additional, Gondo, Y., additional, Masui, Y., additional, Kamide, K., additional, Takahashi, R., additional, Arai, Y., additional, and Maeda, Y., additional

Published
2016
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29. Probiotic Lactobacillus casei strain Shirota relieves stress‐associated symptoms by modulating the gut–brain interaction in human and animal models

Author

Takada, M., primary, Nishida, K., additional, Kataoka‐Kato, A., additional, Gondo, Y., additional, Ishikawa, H., additional, Suda, K., additional, Kawai, M., additional, Hoshi, R., additional, Watanabe, O., additional, Igarashi, T., additional, Kuwano, Y., additional, Miyazaki, K., additional, and Rokutan, K., additional

Published
2016
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30. Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after -irradiation through Wnt/ -catenin pathway

Author

Sakamaki, A., primary, Katsuragi, Y., additional, Otsuka, K., additional, Tomita, M., additional, Obata, M., additional, Iwasaki, T., additional, Abe, M., additional, Sato, T., additional, Ochiai, M., additional, Sakuraba, Y., additional, Aoyagi, Y., additional, Gondo, Y., additional, Sakimura, K., additional, Nakagama, H., additional, Mishima, Y., additional, and Kominami, R., additional

Published
2015
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32. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

Author

Su, Z, Labaj, PP, Li, S, Thierry-Mieg, J, Thierry-Mieg, D, Shi, W, Wang, C, Schroth, GP, Setterquist, RA, Thompson, JF, Jones, WD, Xiao, W, Xu, W, Jensen, RV, Kelly, R, Xu, J, Conesa, A, Furlanello, C, Gao, H, Hong, H, Jafari, N, Letovsky, S, Liao, Y, Lu, F, Oakeley, EJ, Peng, Z, Praul, CA, Santoyo-Lopez, J, Scherer, A, Shi, T, Smyth, GK, Staedtler, F, Sykacek, P, Tan, X-X, Thompson, EA, Vandesompele, J, Wang, MD, Wang, J, Wolfinger, RD, Zavadil, J, Auerbach, SS, Bao, W, Binder, H, Blomquist, T, Brilliant, MH, Bushel, PR, Cain, W, Catalano, JG, Chang, C-W, Chen, T, Chen, G, Chen, R, Chierici, M, Chu, T-M, Clevert, D-A, Deng, Y, Derti, A, Devanarayan, V, Dong, Z, Dopazo, J, Du, T, Fang, H, Fang, Y, Fasold, M, Fernandez, A, Fischer, M, Furio-Tari, P, Fuscoe, JC, Caiment, F, Gaj, S, Gandara, J, Ge, W, Gondo, Y, Gong, B, Gong, M, Gong, Z, Green, B, Guo, C, Guo, L, Guo, L-W, Hadfield, J, Hellemans, J, Hochreiter, S, Jia, M, Jian, M, Johnson, CD, Kay, S, Kleinjans, J, Lababidi, S, Levy, S, Li, Q-Z, Li, L, Li, P, Li, Y, Li, H, Li, J, Lin, SM, Lopez, FJ, Lu, X, Luo, H, Ma, X, Meehan, J, Megherbi, DB, Mei, N, Mu, B, Ning, B, Pandey, A, Perez-Florido, J, Perkins, RG, Peters, R, Phan, JH, Pirooznia, M, Qian, F, Qing, T, Rainbow, L, Rocca-Serra, P, Sambourg, L, Sansone, S-A, Schwartz, S, Shah, R, Shen, J, Smith, TM, Stegle, O, Stralis-Pavese, N, Stupka, E, Suzuki, Y, Szkotnicki, LT, Tinning, M, Tu, B, van Deft, J, Vela-Boza, A, Venturini, E, Walker, SJ, Wan, L, Wang, W, Wieben, ED, Willey, JC, Wu, P-Y, Xuan, J, Yang, Y, Ye, Z, Yin, Y, Yu, Y, Yuan, Y-C, Zhang, J, Zhang, KK, Zhang, W, Zhang, Y, Zhao, C, Zheng, Y, Zhou, Y, Zumbo, P, Tong, W, Kreil, DP, Mason, CE, Shi, L, Su, Z, Labaj, PP, Li, S, Thierry-Mieg, J, Thierry-Mieg, D, Shi, W, Wang, C, Schroth, GP, Setterquist, RA, Thompson, JF, Jones, WD, Xiao, W, Xu, W, Jensen, RV, Kelly, R, Xu, J, Conesa, A, Furlanello, C, Gao, H, Hong, H, Jafari, N, Letovsky, S, Liao, Y, Lu, F, Oakeley, EJ, Peng, Z, Praul, CA, Santoyo-Lopez, J, Scherer, A, Shi, T, Smyth, GK, Staedtler, F, Sykacek, P, Tan, X-X, Thompson, EA, Vandesompele, J, Wang, MD, Wang, J, Wolfinger, RD, Zavadil, J, Auerbach, SS, Bao, W, Binder, H, Blomquist, T, Brilliant, MH, Bushel, PR, Cain, W, Catalano, JG, Chang, C-W, Chen, T, Chen, G, Chen, R, Chierici, M, Chu, T-M, Clevert, D-A, Deng, Y, Derti, A, Devanarayan, V, Dong, Z, Dopazo, J, Du, T, Fang, H, Fang, Y, Fasold, M, Fernandez, A, Fischer, M, Furio-Tari, P, Fuscoe, JC, Caiment, F, Gaj, S, Gandara, J, Ge, W, Gondo, Y, Gong, B, Gong, M, Gong, Z, Green, B, Guo, C, Guo, L, Guo, L-W, Hadfield, J, Hellemans, J, Hochreiter, S, Jia, M, Jian, M, Johnson, CD, Kay, S, Kleinjans, J, Lababidi, S, Levy, S, Li, Q-Z, Li, L, Li, P, Li, Y, Li, H, Li, J, Lin, SM, Lopez, FJ, Lu, X, Luo, H, Ma, X, Meehan, J, Megherbi, DB, Mei, N, Mu, B, Ning, B, Pandey, A, Perez-Florido, J, Perkins, RG, Peters, R, Phan, JH, Pirooznia, M, Qian, F, Qing, T, Rainbow, L, Rocca-Serra, P, Sambourg, L, Sansone, S-A, Schwartz, S, Shah, R, Shen, J, Smith, TM, Stegle, O, Stralis-Pavese, N, Stupka, E, Suzuki, Y, Szkotnicki, LT, Tinning, M, Tu, B, van Deft, J, Vela-Boza, A, Venturini, E, Walker, SJ, Wan, L, Wang, W, Wieben, ED, Willey, JC, Wu, P-Y, Xuan, J, Yang, Y, Ye, Z, Yin, Y, Yu, Y, Yuan, Y-C, Zhang, J, Zhang, KK, Zhang, W, Zhang, Y, Zhao, C, Zheng, Y, Zhou, Y, Zumbo, P, Tong, W, Kreil, DP, Mason, CE, and Shi, L

Abstract

We present primary results from the Sequencing Quality Control (SEQC) project, coordinated by the US Food and Drug Administration. Examining Illumina HiSeq, Life Technologies SOLiD and Roche 454 platforms at multiple laboratory sites using reference RNA samples with built-in controls, we assess RNA sequencing (RNA-seq) performance for junction discovery and differential expression profiling and compare it to microarray and quantitative PCR (qPCR) data using complementary metrics. At all sequencing depths, we discover unannotated exon-exon junctions, with >80% validated by qPCR. We find that measurements of relative expression are accurate and reproducible across sites and platforms if specific filters are used. In contrast, RNA-seq and microarrays do not provide accurate absolute measurements, and gene-specific biases are observed for all examined platforms, including qPCR. Measurement performance depends on the platform and data analysis pipeline, and variation is large for transcript-level profiling. The complete SEQC data sets, comprising >100 billion reads (10Tb), provide unique resources for evaluating RNA-seq analyses for clinical and regulatory settings.

Published
2014

42. A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice

Author

Masuya, H., primary, Nishida, K., additional, Furuichi, T., additional, Toki, H., additional, Nishimura, G., additional, Kawabata, H., additional, Yokoyama, H., additional, Yoshida, A., additional, Tominaga, S., additional, Nagano, J., additional, Shimizu, A., additional, Wakana, S., additional, Gondo, Y., additional, Noda, T., additional, Shiroishi, T., additional, and Ikegawa, S., additional

Published
2007
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45. Burden of family caregivers of centenarians

Author

Konishi, K., Fujimori, J., Kanno, Y., Ebihara, Y., Shimizu, K., Hirose, N., Arai, Y., Takayama, M., Yamamura, K., Nakazawa, S., Gondo, Y., Masui, Y., Inagaki, H., and Kitagawa, K.

Subjects
Health, Seniors
Abstract

To reduce the burden of caregivers and fulfill successful aging of family caregivers self, better supporting systems of caring elderly are requested. A questionnaire was mailed to each caregiver, who lives in Tokyo metropolitan. Quesions included burden of the caregivers and ADL of centenarians. Physical and psychological burden of caregivers is storongly affected by centenarian's ADL,cognitive level, and abnormal behaviors. Family caregivers of centenarians had a lower accumulated fatigue level and rated their health as very good to good, despite being older themselves and in spite of impoverished ADL of centenarians. Family caregivers of centenarians perceive their work not just duty or responsibility but worthwhile and satisfying. The care of centenarians might be possible model for successful caring.

Published
2002

46. The medical records of Japanese centenarians and its effects on their autonomy

Author

Takayama, M., Masui, Y., Nakazawa, S., Yamamura, K., Arai, Y., Shimizu, K., Ebihara, Y., Abe, Y., Inagaki, H., Gondo, Y., Konishi, K., Kanno, Y., Fujimori, J., Kitagawa, K., and Hirose, N.

Subjects
Health, Seniors
Abstract

We examined the medical records of Japanese centenarians to clarify whether centenarians lived free from diseases, what kinds of morbidity they had experienced, and how such morbidity affected their autonomy. Three hundreds and thirty five centenarians living in Tokyo area were enrolled in this study. Informed consent was obtained in written form from the centenarians or their proxies. Their medical records were questioned by questionnaire and/or interview. The levels of activities of daily living (ADL) and cognitive function were also assessed using Barthel Index and mini-mental state examination (MMSE), respectively. The levels of ADL and cognitive function were significantly lower in female centenarians. About one third of centenarians escaped from grave diseases. Among their present and previous diseases, cataract, coronary and valvular heart diseases, hypertension, and cerebrovascular diseases were frequently reported. The incidence of fracture was significantly high in female centenarians. Another remarkable finding was very low incidence of diabetes mellitus (DM). The levels of ADL and cognitive function of the centenarians with the history of fracture were lower, suggesting that fracture, irrespective of its location, affected their autonomy. In conclusion, one third of Japanese centenarians escape from severe diseases, DM is unfavorable for longevity, and prevention of fracture may improve autonomy in the oldest old.

Published
2002

47. The influence of personality traits on longevity and centenarians' ADL

Author

Yukie. M., Gondo, Y., Hiroki, I., Koji, K., Nobuyoshi, H., Yasumichi, A., Michiyo, T., Yoshinori, E., Ken, Y., Susumu, N., Kenichiro, S., Kanoko, K., Yoshiko, K., and Junko, F.

Subjects
Health, Seniors
Abstract

The purpose of this study is to examine whether the personality contributes to longevity and centenarians[infinity]fADL. The NEO-FFI was administered to 272 centenarians and 1812 elderly people 65 through to 85 years old in Tokyo. Comparisons of each personality trait between the centenarians and the 65-85 elderly people showed the centenarians[infinity]f characteristics: Agreeableness was lower than the elderly in men and women, Neuroticism was higher in men, Conscientiousness and Extraversion were higher in women. Relations of the profiles of 5 personality traits and the ADL scores in the centenarians showed that the ADL level differed with the type of personality profiles. The higher level of ADL observed in the higher neuroticism and lower E, O, A, C type and the lower neuroticism and higher E, O, A, C type on ADL level than other personality types. These results suggested that the personality contributed to longevity and centenarians' ADL.

Published
2002

48. The association of dopamine receptor 4 and serotonin transpotter gene polymorphism with longivity

Author

Gondo, Y., Hirose, N., Arai, Y., Masui, Y., Ohno, Y., Inagaki, H., Kitagawa, K., Yamamura, K., Nakazawa, S., Takayama,M., Ebihara, Y., Konishi, K., Kanno, Y., Fujimori, J., and Shimizu, K.

Subjects
Gerontology -- Research, Dopamine receptors -- Research, Centenarians -- Physiological aspects, Serotonin -- Research, Health, Seniors
Abstract

It is reported that some personality traits in centenarians are different from those in younger controls. Recently polymorphism of dopamine receptor 4(D4DR) and serotonin transporter (5HTT) genes are shown to be related with novelty seeking and neurosis, respectively. It is not reported that polymorphism of these genes is associated with longevity. One hundred and forty five female centenarians living in Tokyo metropolitan area were enrolled in this study. As control group. 173 young females(average age 18.9 years old) were recruited. Polymorphism of D4DR in centenarians was not different from that in younger control and was not associated with the level of ADL and cognitive function of the centenarians. As for the polymorphism of 5HTT, frequency of 1 allele in centenarians was significantly higher than that in control. Centenarians with 1 allele have high level of ADL and serum albumin, compared with those with s allele. These data suggests that 5HTT polymorphism seems to be associated with longevity through behavioral and biological factors.

Published
2002

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