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12. [Helicobacter pylori infection: a potential pathogenic factor for laryngeal squamous cell carcinoma].

Author

Gong HL, Shi Y, Zhou L, Tao L, Ji J, and Chen HW

Subjects
Adult, Aged, Carcinoma, Squamous Cell complications, Carcinoma, Squamous Cell pathology, Female, Helicobacter pylori isolation & purification, Humans, Laryngeal Neoplasms complications, Laryngeal Neoplasms pathology, Male, Middle Aged, Polyps complications, Polyps microbiology, Polyps pathology, Vocal Cords microbiology, Vocal Cords pathology, Carcinoma, Squamous Cell microbiology, Helicobacter Infections complications, Laryngeal Neoplasms microbiology
Abstract

Objective: To investigate the difference in Helicobacter pylori (Hp) infection rate between the patients with laryngeal squamous cell carcinoma and the patients with benign laryngeal lesions and to explore the role of Hp infection in the pathogenesis of laryngeal squamous carcinoma., Methods: Nested polymerase chain reaction (nPCR) and Hp culture were used to identify the Hp in laryngeal mucosa in 30 patients with laryngeal carcinoma and 15 patients with benign laryngeal lesions including polyps of vocal cords or epiglottic cysts., Results: nPCR showed that Hp-positive rate (73.3%) of patients with laryngeal carcinoma was significantly higher than that (20.0%) of control patients with benign laryngeal lesions (χ(2) = 11.520, P = 0.010). Regarding the 22 positive neoplastic cases that have 44 tissues, out of the 22 tumor tissues, 10 were positive with Hp (45.4%), and among 22 tissues beside the tumor, 19 were positive (86.4%). This event also indicated a statistical significance (χ(2) = 4.697, P = 0.030). Hp culture showed that Hp was negative in all specimens., Conclusions: Hp exist in the laryngeal mucosa, but with the higher rate of Hp infection in the patients with laryngeal squamous cell carcinoma than that in the patients with benign laryngeal lesions, which suggests Hp may be one of pathogenic factors of laryngeal squamous cell carcinoma.

Published
2010

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