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The most active catalysts so far successful in hydrogenation reduction of CO2 are mainly heterogeneous Cu‐based catalysts. The complex coordination environments and multiple active sites in heterogeneous catalysts result in low selectivity of target product, while molecular catalysts with well‐defined active sites and tailorable structures allow mechanism‐based performance optimization. Herein, we firstly report a single ethylenediaminetetraacetic acid (EDTA) molecular‐level immobilized on the surface of carbon nanotube as a catalyst for transferring CO2 to CH4 with an excellent performance. This catalyst exhibits a high Faradaic efficiency of 61.6 % toward CH4, a partial current density of −16.5 mA cm−2 at a potential of −1.3 V versus reversible hydrogen electrode. Density functional theory calculations reveal that the Lewis basic COO− groups in EDTA molecule are the active sites for CO2 reduction reaction (CO2RR). The energy barrier for the generation of CO from *CO intermediate is as high as 0.52 eV, while the further protonation of *CO to *CHO follows an energetic downhill path (−1.57 eV), resulting in the high selectivity of CH4. This work makes it possible to control the product selectivity for CO2RR according to the relationship between the energy barrier of *CO intermediate and molecular structures in the future. [ABSTRACT FROM AUTHOR]

The most active catalysts so far successful in hydrogenation reduction of CO2 are mainly heterogeneous Cu‐based catalysts. The complex coordination environments and multiple active sites in heterogeneous catalysts result in low selectivity of target product, while molecular catalysts with well‐defined active sites and tailorable structures allow mechanism‐based performance optimization. Herein, we firstly report a single ethylenediaminetetraacetic acid (EDTA) molecular‐level immobilized on the surface of carbon nanotube as a catalyst for transferring CO2 to CH4 with an excellent performance. This catalyst exhibits a high Faradaic efficiency of 61.6 % toward CH4, a partial current density of −16.5 mA cm−2 at a potential of −1.3 V versus reversible hydrogen electrode. Density functional theory calculations reveal that the Lewis basic COO− groups in EDTA molecule are the active sites for CO2 reduction reaction (CO2RR). The energy barrier for the generation of CO from *CO intermediate is as high as 0.52 eV, while the further protonation of *CO to *CHO follows an energetic downhill path (−1.57 eV), resulting in the high selectivity of CH4. This work makes it possible to control the product selectivity for CO2RR according to the relationship between the energy barrier of *CO intermediate and molecular structures in the future. [ABSTRACT FROM AUTHOR]

The most active catalysts so far successful in hydrogenation reduction of CO2 are mainly heterogeneous Cu‐based catalysts. The complex coordination environments and multiple active sites in heterogeneous catalysts result in low selectivity of target product, while molecular catalysts with well‐defined active sites and tailorable structures allow mechanism‐based performance optimization. Herein, we firstly report a single ethylenediaminetetraacetic acid (EDTA) molecular‐level immobilized on the surface of carbon nanotube as a catalyst for transferring CO2 to CH4 with an excellent performance. This catalyst exhibits a high Faradaic efficiency of 61.6 % toward CH4, a partial current density of −16.5 mA cm−2 at a potential of −1.3 V versus reversible hydrogen electrode. Density functional theory calculations reveal that the Lewis basic COO− groups in EDTA molecule are the active sites for CO2 reduction reaction (CO2RR). The energy barrier for the generation of CO from *CO intermediate is as high as 0.52 eV, while the further protonation of *CO to *CHO follows an energetic downhill path (−1.57 eV), resulting in the high selectivity of CH4. This work makes it possible to control the product selectivity for CO2RR according to the relationship between the energy barrier of *CO intermediate and molecular structures in the future. [ABSTRACT FROM AUTHOR]

The most active catalysts so far successful in hydrogenation reduction of CO2 are mainly heterogeneous Cu‐based catalysts. The complex coordination environments and multiple active sites in heterogeneous catalysts result in low selectivity of target product, while molecular catalysts with well‐defined active sites and tailorable structures allow mechanism‐based performance optimization. Herein, we firstly report a single ethylenediaminetetraacetic acid (EDTA) molecular‐level immobilized on the surface of carbon nanotube as a catalyst for transferring CO2 to CH4 with an excellent performance. This catalyst exhibits a high Faradaic efficiency of 61.6 % toward CH4, a partial current density of −16.5 mA cm−2 at a potential of −1.3 V versus reversible hydrogen electrode. Density functional theory calculations reveal that the Lewis basic COO− groups in EDTA molecule are the active sites for CO2 reduction reaction (CO2RR). The energy barrier for the generation of CO from *CO intermediate is as high as 0.52 eV, while the further protonation of *CO to *CHO follows an energetic downhill path (−1.57 eV), resulting in the high selectivity of CH4. This work makes it possible to control the product selectivity for CO2RR according to the relationship between the energy barrier of *CO intermediate and molecular structures in the future. [ABSTRACT FROM AUTHOR]

eNRR is a promisingly environment-friendly strategy to obtain ammonia under ambient conditions. For metal-based catalysts, the competitive adsorption of H+ over N2 remains the primary hurdle for high ammonia yield and faradaic efficiency. Carbon-based metal-free catalysts attract our attention for the potential of being promising NRR catalysts due to their natural low HER activity. In this study, we prepared a modified Zn-based metal–organic framework (Zn-BTC) decorated with Cl ions by simply adding NaCl in the synthetic process. The existence of Cl ions in the framework contributes to the generation of large pores during thermolysis. Moreover, –Cl and –COCl species were formed in situ and connected with carbon atoms in the defect area. Benefitting from such a structure, this catalyst achieves a high ammonia yield rate of 103.96 μg h−1 mgcat−1 and a faradaic efficiency of 21.71% at room temperature. Theoretical results also proved that the newly produced –COCl and –Cl functional groups could attract more electrons from adjacent carbon atoms due to their stronger electronegativity, thus improving its affinity towards N2 while lowering the HER activity as reactive sites. [ABSTRACT FROM AUTHOR]

Introduction: A three-dimensional (3D) model of the pelvic vessels was reconstructed before surgery to aid in the understanding of the individual anatomy and help guide lymphadenectomy performance. Material and methods: Thirty patients with early-stage cervical cancer who were scheduled for lymphadenectomy at Nanfang Hospital, Southern Medical University from January 2017 to June 2017 were included. Three-dimensional models of the pelvic vessels were obtained. Results: All 3D models of the 30 patients were reconstructed successfully and were consistent with the operative findings.The most common structural types posterior to the common iliac artery (CIA) and CIA bifurcation (CIAB) were non-vessel structures (23/30 patients) and the common iliac vein (CIV) (27/30); these were observed separately on the left pelvic vein. The confluence of common iliac vein (CCIV) (29/30) and CIV (20/30) were most commonly observed posterior to the CIA and CIAB; these were observed separately on the right pelvic vein. Venous abnormalities were identified in 15 patients. There were variants in venous confluence shown to be homolateral to the CIV (2/15) and contralateral to the CIV (2/15) and CCIV (4/15). Conclusions: Three-dimensional models of the pelvic vessels can provide information on individual anatomy features that can help guide lymphadenectomy performance. [ABSTRACT FROM AUTHOR]

Objective: We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)‐sensitive and ‐resistant ovarian cancer. Methods: OVCAR3 and SKOV3 were selected and the corresponding DDP‐resistant cells were constructed. Cell viability, proliferation, apoptosis, cycle were performed. Expression cAMP, PKA, CREB, phosphorylation of CREB and FtMt were detected. The roles of roflumilast in development of DDP‐sensitive and ‐resistant ovarian cancer were confirmed by xenograft model. Results: Roflumilast + DDP inhibited cell proliferation, and induced cell apoptosis and G0/G1 arrest in OVCAR3 and SKOV3 cells, roflumilast induced expression of FtMt, the activity of cAMP and PKA and phosphorylation of CREB in ovarian cancer cells and the above‐effect were inhibited by H89. Downregulation of CREB inhibited the roflumilast‐increased DDP sensitivity of ovarian cancer cells, and the roflumilast‐induced FtMt expression and phosphorylation of CREB. Also, roflumilast reversed cisplatin‐resistance, and induced expression of FtMt and activation of cAMP/PKA/CREB in DDP‐resistant ovarian cancer cells. Similarly, treated with H89 or downregulation of CREB inhibited the changes induced by roflumilast. In vivo, roflumilast inhibited the development of SKOV3 or SKOV3‐DDP‐R xenograft models. Conclusions: Roflumilast enhanced DDP sensitivity and reversed the DDP resistance of ovarian cancer cells via activation of cAMP/PKA/CREB pathway and upregulation of the downstream FtMt expression, which has great promise in clinical treatment. [ABSTRACT FROM AUTHOR]

Transition metal sulfides have attracted tremendous attention as promising lithium-ion anodes due to their natural abundance, intrinsic safety and high theoretical capacity. However, low conductivity and dramatic volume variation hinder their further application in lithium storage. Here, we reported a facile metal–organic framework (MOF)-derived self-template approach to prepare hollow cobalt sulfide polyhedra with vertically aligned metallic phase MoS2 nanosheets (denoted as CoS@1T-MoS2) as efficient anode materials for lithium storage. Benefiting from the high intrinsic conductivity of metallic phase MoS2, the hierarchical hollow framework, and the synergistic effect of interior cobalt sulfide and exterior metallic MoS2, the CoS@1T-MoS2 composite delivers a high reversible capacity of 1269 mA h g−1 after 100 cycles at a current density of 100 mA g−1 and 936 mA h g−1 at a current density of 1000 mA g−1 after 220 cycles. [ABSTRACT FROM AUTHOR]

The most active catalysts so far successful in hydrogenation reduction of CO 2 are mainly heterogeneous Cu-based catalysts. The complex coordination environments and multiple active sites in heterogeneous catalysts result in low selectivity of target product, while molecular catalysts with well-defined active sites and tailorable structures allow mechanism-based performance optimization. Herein, we firstly report a single ethylenediaminetetraacetic acid (EDTA) molecular-level immobilized on the surface of carbon nanotube as a catalyst for transferring CO 2 to CH 4 with an excellent performance. This catalyst exhibits a high Faradaic efficiency of 61.6 % toward CH 4 , a partial current density of -16.5 mA cm -2 at a potential of -1.3 V versus reversible hydrogen electrode. Density functional theory calculations reveal that the Lewis basic COO - groups in EDTA molecule are the active sites for CO 2 reduction reaction (CO 2 RR). The energy barrier for the generation of CO from *CO intermediate is as high as 0.52 eV, while the further protonation of *CO to *CHO follows an energetic downhill path (-1.57 eV), resulting in the high selectivity of CH 4 . This work makes it possible to control the product selectivity for CO 2 RR according to the relationship between the energy barrier of *CO intermediate and molecular structures in the future., (© 2021 Wiley-VCH GmbH.)

We have collected the data of five patients with ovarian teratoma and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis admitted to the Southern Hospital of Southern Medical University from June 2014 to December 2017, we found that all of them started with psychiatric symptoms, four had autonomic nervous system dysfunction, while all of them exposed to abnormal brain and pelvic imaging, four patients required mechanical ventilation to assist breathing during the hospital stay. The serum anti-NMDAR antibodies were positive in five patients. After immunotherapy and surgery, all patients showed favorable prognosis. Pathology: four mature teratomas and one immature teratoma. In conclusion, patients with ovarian teratoma with anti-NMDAR encephalitis often begins with neurological and psychiatric symptoms, it is easy to be misdiagnosed due to the lack of overt symptoms, while the early detection and tumor resection combined with immunotherapy will win favorable prognosis.

Developing highly active electrocatalysts with superior durability for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in the same electrolyte is a grand challenge to realize the practical application of electrolysis water for producing hydrogen. In this work, an ultrasmall Ru/Cu-doped RuO 2 complex embedded in an amorphous carbon skeleton is synthesized, through thermolysis of Ru-modified Cu-1,3,5-benzenetricarboxylic acid (BTC), as a highly efficient bifunctional catalyst for overall water splitting electrocatalysis. The ultrasmall Ru nanoparticles in the complex expose more activity sites for hydrogen evolution and outperform the commercial Pt/C. Meanwhile, the ultrasmall RuO 2 nanoparticles exhibit superior oxygen evolution performance over commercial RuO 2 , and the doping of Cu into the ultrasmall RuO 2 nanoparticles further enhances the oxygen evolution performance of the catalyst. The outstanding OER and decent HER catalytic activity endow the complex with impressive overall water splitting performance superior to that of the state-of-the-art electrocatalysts, which just require 1.47 and 1.67 V to achieve a current density of 10 mA cm -2 and 100 mA cm -2 . The density functional theory calculations reveal that a Cu dopant could effectively tailor the d-band center, thereby tuning electronic structure of Ru activity sites on the RuO 2 (110) plane and ultimately improving the OER performance of RuO 2 ., (© 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.)

Objective: The paper is an attentative effort to evaluate the reaction and mechanism of estrogen on pregnant rabbits with acute lung injury caused by hemorrhagic shock., Methods: Sixty pregnant New Zealand white rabbits were randomly divided into 6 groups, with 10 rabbits in each group, namely normal control group (NG group, with anesthesia only), estrogen group (E(2)G group, with additional estrogen injection at 60 min) and the other four hemorrhagic shock groups underwent hemorrhagic shock (i.e. E(2)SG, FSG, SBSG, E(2)SBSG group; mean blood pressure- 40 mmHg (1 mmHg = 0.133 kPa) by phlebotomy for 15 min. After maintenance of the pressure for 45 min, the rabbits were treated with E(2) (0.37 mg/kg), fructose injection (5%, 2 ml/kg), the p38 mitogen-activated protein kinases (p38MAPK) inhibitor SB-203580 (2 mg/kg) or E(2) plus SB-203580. Tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) were measured at different time points (0 min, 60 min, 80 min and 260 min), lung tissue methane dicarboxylic aldehyde (MDA) level, lung tissue myeloperoxidase (MOP), superoxide dismutase (SOD) activity, lung tissue dry weight/wet weight (DW/WW) value were measured after the experiment was finished, pulmonary pathology of the rabbits was observed., Result: (1) Serum TNF-α level of NG group and E(2)SG group were not significantly different compared with the other four groups at the 0 min and 60 min. At 80 min and 260 min of experiment, serum TNF-α level of all the four shock groups were increased, E(2)SG group [(172.4 ± 16.0) and (216.7 ± 18.6) ng/L], FSG group [(171.6 ± 9.1) and (263.9 ± 7.8) ng/L], SBSG group [(172.8 ± 7.2) and (300.6 ± 4.8) ng/L], E(2)SBSG group [(167.9 ± 4.8 ) and (261.8 ± 9.6) ng/L], and significantly higher than NG group and E(2)G group, separately (P < 0.05). (2) Serum IL-6 level of NG group and E(2)SG group were not significantly different compared with the other four groups at the 0 min, 60 min and 80 min. At 260 min, the serum IL-6 level [(98.3 ± 0.9) and (110.4 ± 1.8) ng/L; (120.9 ± 2.3) and (109.8 ± 2.6) ng/L] of the four shock groups (E(2)SG, FSG, SBSG, E(2)SBSG group) were significantly higher than NG group and E(2)G group (P < 0.05). (3) Lung tissue MDA level [(2.20 ± 0.12), (2.57 ± 0.11), (3.17 ± 0.08), (2.75 ± 1.09) nmol/mg] and MPO activity [(4.45 ± 0.25), (6.65 ± 0.56), (9.55 ± 0.30), (6.78 ± 0.11) U/mg] of the four shock groups (E(2)SG, FSG, SBSG, E(2)SBSG group) were higher than NG group and E(2)G group (P < 0.05). (4) Lung tissue SOD activity [(51.8 ± 1.8), (40.2 ± 1.5), (30.0 ± 1.7), (41.2 ± 2.0) U/mg] was significantly higher in the four shock groups (E(2)SG, FSG, SBSG, E(2)SBSG group) compared with NG group and E(2)G group (P < 0.05). (5) Lung tissue DW/WW value (0.143 ± 0.008, 0.127 ± 0.008, 0.109 ± 0.006, 0.125 ± 0.008) was significantly lower in the four shock groups (E(2)SG, FSG, SBSG, E(2)SBSG group) compared with NG group and E(2)G group (P < 0.05). (6) Lung tissue of the rabbits in NG group and E(2)G group is basically normal without obvious pathology changes. Lung tissue pathological damage of rabbits was observed in the four shock groups, and the pathological damage of rabbits in SBSG group was most serious., Conclusion: Estrogen can reduce acute lung injury of pregnant rabbits with hemorrhagic shock, the p38MAPK pathway plays a critical role in mediating the salutary effects of E(2) on shock-induced acute lung injury.

Objective: To evaluate the effects of estrogen on renal function of pregnant rabbits with hemorrhagic shock., Methods: Forty pregnant New Zealand white rabbits were randomized into 4 groups, namely normal control group (NG group, with anesthesia only), estrogen group (E2 group, with additional estrogen injection at 60 min), estrogen-hemorrhagic shock (E2SG) group and fructose-hemorrhagic shock (FSG) group. In the latter two groups, the rabbits were subjected to phlebotomy for 15 min to induce hemorrhagic shock with a blood pressure of 40 mmHg; after maintenance of the pressure for 45 min, intravenous injections of estrogen or fructose were given before resuscitation 20 min later. Blood urea nitrogen (BUN) and creatinine (Cr) concentration were measured at different time points and renal pathology of the rabbits was observed., Results: No significant differences were founding serum BUN and Cr levels between NG and E2G groups during the experiment. In FSG and E2SG groups, serum BUN level began to increase at 80 min after hemorrhagic shock and was significantly higher in FSG group (P<0.05); serum Cr level increased progressively from the start of the experiment and began to decrease at 60 min, with a faster rate of reduction in E2SG group (P<0.05)., Conclusion: Estrogen can effectively lower serum BUN and Cr levels and ameliorate renal pathologies to offer protective effect in pregnant rabbits against hemorrhagic shock.

Objective: To evaluate the significance of the serum cystatin C (Cys-C) in assessing renal dysfunction in preeclamptic women., Methods: Ninety-six women with normal pregnancies and 48 with severe preeclampsia were examined for 24-hour creatinine clearance (CrCl), serum creatinine (Scr), Cys-C, uric acid (UA) and beta microglobulin (MG) concentrations during the second and third trimesters and postpartum in severe preeclamptic patients. These indexes were analyzed to estimate the glomerular filtration rate., Results: The concentrations of Scr, UA and MG were significantly higher in the third trimester than in the second trimester in women with normal pregnancies, where serum Cys-C levels showed no significant variations. Severe preeclamptic patients exhibited significantly higher serum Cys-C levels in the third than in the second trimester. Correlation analyses demonstrated significant negative correlations between Cys-C and 24-hour CrCl in the second and third trimesters in all the 144 pregnant women and in the postpartum period in severe preeclamptic patients., Conclusion: Serum Cys-C can serve as a good indicator for assessing renal function in severe preeclamptic women from antepartum to postpartum periods.

microRNAs (miRNAs) are non-coding RNA transcripts thought to be instrumental in controlling eukaryotic cell function. This study aimed to identify miRNAs associated with the differential expression of estrogen receptor α (ERα) and progesterone receptor (PR) in uterine endometrial cancer. First, the pathology of Ishikawa and KLE cell lines was identified by transplant and biopsy. Expression levels of ERα and PR and their response to estrogen and progesterone were examined, and total RNA was isolated to identify differentially expressed miRNAs by microarray analysis. miRNAs targeting ESR1 and PGR were predicted by miRANDA and TargetScan software, and their expression levels in cell lines and in patient samples were validated by real-time RT-PCR. Ishikawa and KLE represent estrogen-dependent and estrogen-independent endometrial cancers, respectively. As identified by miRNA microarray, 126 miRNAs were differentially expressed between the two cell lines; hsa-miR-100 and hsa-miR-99a were predicted to target ESR1, and hsa-miR-378 and hsa-miR-768-3p to target PGR. The differential expression of these miRNAs between Ishikawa and KLE was consistent in vivo and in vitro. Hsa-miR-100 was significantly down-regulated in the estrogen-dependent endometrial cancer samples as compared to the estrogen-independent samples and thus has the potential to target ESR1.