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613 results on '"Gong, Wenbin"'

23. Subphenotyping heterogeneous patients with chronic critical illness to guide individualised fluid balance treatment using machine learning: a retrospective cohort study

Author

Liu, Peizhao, Li, Sicheng, Zheng, Tao, Wu, Jie, Fan, Yong, Liu, Xiaoli, Gong, Wenbin, Xie, Haohao, Liu, Juanhan, Li, Yangguang, Jiang, Haiyang, Zhao, Fan, Zhang, Jinpeng, Wu, Lei, Ren, Huajian, Hong, Zhiwu, Chen, Jun, Gu, Guosheng, Wang, Gefei, Zhang, Zhengbo, Wu, Xiuwen, Zhao, Yun, and Ren, Jianan

Published
2023
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38. 4‐Octyl itaconate blocks GSDMB‐mediated pyroptosis and restricts inflammation by inactivating granzyme A.

Author

Gong, Wenbin, Fu, Hangyu, Yang, Kui, Zheng, Tao, Guo, Kun, and Zhao, Wei

Abstract

GSDMB‐mediated pyroptosis facilitates a pro‐inflammatory immune microenvironment and needs to be tightly regulated to avoid excessive inflammation. Here, we provide evidence that itaconate and its cell‐permeable derivative 4‐octyl itaconate (4‐OI) can significantly inhibit GSDMB‐rendered pyroptotic activity independent of Nrf2. 4‐OI interferes proteolytic process of GSDMB by directly modifying Cys54, Cys148 and Ser212 on granzyme A (GrzA), a serine protease that site‐specifically cleaves the inter‐domain linker of GSDMB, instead of interaction with GSDMB, thereby blocking pyroptosis and exerts anti‐inflammatory effects. Moreover, 4‐OI alleviates inflammation by suppressing GSDMB‐induced pyroptotic cell death during acute colitis models in intestinal epithelial GSDMB conditional transgenic mice. Our data expand the role of 4‐OI as a crucial immunometabolic derivative that regulates innate immunity and inflammation through a newly identified posttranslational modification, and targeting of pyroptosis by 4‐OI therefore holds potent therapeutic potential for primarily inflammatory and/or autoimmune diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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40. A Beidou Laser Link Allocation Scheme Based on Network Throughput Optimization

Author

Huang, Zheng, Gong, Wenbin, Shao, FengWei, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Yang, Changfeng, editor, and Xie, Jun, editor

Published
2021
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