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1. Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©

Author

Pato-Cour, Esperanza, Borrego-Sanz, Lara, Domínguez-Álvaro, Marta, Sánchez-Alonso, Fernando, Rodríguez-González, Fayna, Tejera-Santana, Marta, Esteban-Ortega, Mar, García-Lozano, Isabel, Martínez-Costa, Lucia, González-Ocampo, Samuel, Sainz-de-la-Maza, Maite, Moll-Udina, Aina, Plaza, Zulema, Fonollosa, Alejandro, Artaraz, Joseba, Díaz-Valle, Teresa, Gurrea-Almela, Maria, Díaz-Valle, David, and Méndez-Fernández, Rosalía

Published
2024
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2. Comparative Analysis of Proteinuria and Longitudinal Outcomes in Immune Complex Membranoproliferative Glomerulonephritis and C3 Glomerulopathy

Author

Cavero, Teresa, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Mendiola, Nuria Rodríguez, Cruz, Sonia, Rodríguez, Adela, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez-Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sanchez de la Nieta, Maria Dolores, Rodríguez, Eva, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, López-Rubio, Maria Esperanza, Fenollosa, María Ángeles, Martín-Penagos, Luis, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Caravaca-Fontán, Fernando, Toledo-Rojas, Remedios, Pérez-Canga, José Luis, Martínez-Miguel, Patricia, Da Silva, Iara, Verdalles, Úrsula, Albornoz, Macarena, Durán López, Carmen Mercedes, Fernández-Juárez, Gema, and Praga, Manuel

Published
2025
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5. Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis

Author

Pato-Cour, Esperanza, Martin-Martinez, Mª Auxiliadora, Borrego-Sanz, Lara, Martinez-Costa, Lucia, Esteban-Ortega, Mar, Sánchez-Costa, Jesús T., Cordero-Coma, Miguel, Fonollosa, Alejandro, Diaz-Valle, Teresa, Rodríguez-González, Fayna, Sainz-de-la-Maza, Maite, Diaz-Valle, David, Gonzalez-Ocampo, Samuel, López-Sierra, Sara, Garcia-Lozano, Isabel, Garzo-García, Irene, Artaraz, Joseba, Gurrea-Almela, Maria, Tejera, Marta, Moll-Udina, Aina, Valls-Pascual, Elia, Muñoz-Fernández, Santiago, and Méndez-Fernandez, Rosalía

Published
2023
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6. Effect of Immunosuppressive Treatments on Kidney Outcomes After Gross Hematuria-Related Acute Kidney Injury in Older Patients With IgA Nephropathy

Author

Sevillano, Angel M., Caravaca-Fontán, Fernando, Garcia-Galan, Lucia Cordero, Fernandez-Juarez, Gema, Lopez-Revuelta, Katia, Guzmán, Diomaris A., Martín-Reyes, Guillermo, Quintana, Luis F., Rodas, Lida M., Sanchez de la Nieta, Maria Dolores, Rabasco, Cristina, Espinosa, Mario, Diaz-Encarnación, Monserrat, San Miguel, Luz, Barrios, Clara, Rodriguez, Eva, Garcia, Patricia, Valera, Alfonso, Peña, Jessy-Korina, Shabaka, Amir, Velo, Mercedes, Sierra, Milagros, Gonzalez, Fayna, Fernandez-Reyes, Maria José, Heras, Manuel, Delgado, Patricia, Gutierrez, Eduardo, Moreno, Juan Antonio, Praga, Manuel, and Cordero Garcia-Galan, Lucia

Published
2023
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7. Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms.

Author

Martínez-Quintana, Efrén, Codana-Alcántara, Karen, Montesdeoca-Naranjo, Hector M., García-Suárez, Marta Isabel, Fleitas-Álvarez, María Pino, Alcántara-Castellano, María, Ruiz-Castellano, Alejandro, González-Isasi, Ana, Rodríguez-González, Fayna, and Bosch-Casañas, Esperanza

Subjects
PSYCHOTHERAPY, CONGENITAL heart disease, CARDIAC patients, MENTAL depression, SATISFACTION
Abstract

Introduction: Anxiety and depression are significant mental health concerns for individuals with congenital heart disease (CHD). As group therapy has proven to be a valuable and effective treatment option for managing anxiety and depression, the aim of this study was to determine its effects on patients with CHD and anxious–depressive symptoms. Methods: We used non-pharmacological psychological group intervention, of six weekly sessions of 90 min each, administered by trained personnel, in adult patients with CHD. Measurement tools included quality of life (Euro quality of life-5D questionnaire), self-esteem (Rosenberg Self-Esteem Scale), anxiety (State–Trait Anxiety Inventory), depression (Beck Depression Inventory-II), and satisfaction surveys. Results: A total of 18 out of 21 CHD patients (mean age 35.8 ± 9.0 years old and 13 (72%) females) completed the program. According to CHD complexity, five (28%) patients had mild, six (33%) moderate, and seven (38%) great defects. Patients with CHD scored significantly higher in the Euro quality of life visual analogue scale (7.83 ± 1.4 vs. 7.14 ± 1.6, p = 0.012) and lower in the Beck Depression Inventory-II (12.3 ± 10.9 vs. 18.1 ± 12.1, p = 0.003) post-program than pre-intervention. Meanwhile, the Rosenberg Self-Esteem Scale score was close to reaching statistical significance (27.4 ± 6.0 vs. 25.1 ± 5.4, p = 0.051), while the State–Trait Anxiety Inventory did not. Finally, participants scored high in the satisfaction questionnaire at the end of the sessions, on a scale from 0 to 3, especially in the questions related to feeling comfortable with others (2.5 ± 0.6), recommending the program (2.3 ± 0.6), or being willing to attend future sessions (2.6 ± 0.8). Conclusions: Group psychological therapy proved to be a useful tool to reduce depressive symptomatology after a 6-week program, providing a comfortable environment to patients with CHD. [ABSTRACT FROM AUTHOR]

Published
2025
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8. Correction to: Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis

Author

Pato-Cour, Esperanza, Martin-Martinez, Mª Auxiliadora, Borrego-Sanz, Lara, Martinez-Costa, Lucia, Esteban-Ortega, Mar, Sánchez-Costa, Jesús T., Cordero-Coma, Miguel, Fonollosa, Alejandro, Diaz-Valle, Teresa, Rodríguez-González, Fayna, Sainz-de-la-Maza, Maite, Diaz-Valle, David, Gonzalez-Ocampo, Samuel, López-Sierra, Sara, Garcia-Lozano, Isabel, Garzo-García, Irene, Artaraz, Joseba, Gurrea-Almela, Maria, Tejera, Marta, Moll-Udina, Aina, Valls-Pascual, Elia, Muñoz-Fernández, Santiago, and Méndez-Fernandez, Rosalía

Published
2023
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9. Validation of a Histologic Scoring Index for C3 Glomerulopathy

Author

Cavero, Teresa, Sevillano, Ángel, Gutiérrez, Eduardo, Morales, Enrique, González, Lucia, Camacho Galán, Rafael, Gabaldón Domínguez, Alejandra, Garrido, Marta, Navarro, Alexandra, Cortés, José Antonio, Pascual Martin, Alejando, Pérez-Ebri, M. Luisa, Cabrera-Pérez, Rocío, Panizo Santos, Ángel, Yébenes Gregorio, Laura, García Fernández, Maria Eugenia, Gimeno, Javier, Cannata Ortiz, Pablo, Roselló Sastre, Esther, Saiz, Ana, Salido Ruiz, Eduardo, Rodríguez, Rosa, Corbacho Cuevas, Cesáreo, Crespo, Francisco Díaz, Arce, Yolanda, Garcia-Cuerva Calvar, Maria Soledad, Saus, Carles, Guerrero Márquez, Carmen, García-Herrera, Adriana, Gomà Gallego, Montserrat, López Álvarez, Dolores, Meléndez Muñoz, Cristina, Centeno, Macarena, Ferri Ñíguez, Belén, Mosquera Reboredo, Juan, Vázquez Martul, Eduardo, Pérez Gutiérrez, Sofía, Caravaca-Fontán, Fernando, Trujillo, Hernando, Alonso, Marina, Díaz-Encarnación, Montserrat, Cabello, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Eva, de la Cerda, Francisco, Pérez de José, Ana, López, Inmaculada, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Lumbreras, Javier, Allende, Natalia, Sanchez de la Nieta, Maria Dolores, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, Illescas, Maria Luisa, Calvo, Consuelo, Oviedo, Victoria, Da Silva, Iara, Goicoechea de Jorge, Elena, Caravaca, Francisco, and Praga, Manuel

Published
2021
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11. Risk Factors for Chronic Kidney Disease in Adult Patients with Congenital Heart Disease and Its Relationship with Cardiovascular Mortality.

Author

Martínez-Quintana, Efrén and Rodríguez-González, Fayna

Subjects
*DISEASE risk factors, *CONGENITAL heart disease, *AGE groups, *CARDIAC patients, *LOGISTIC regression analysis
Abstract

Background: Patients with congenital heart disease (CHD) show risk factors for chronic kidney disease (CKD) and it is well known that CKD has a large negative impact on survival. Methods: Observational and prospective cohort study. Adult CHD patients and controls were matched for age and sex. Results: A total of 657 CHD adult patients (cases) and 1954 controls were studied. Median age in CHD patients was 30 (17–62) years and 373 (57%) were male. The prevalence of CKD (Glomerular filtration rate (GFR) < 60 mL/min/1.73 m2) was 0.2% and 4.5% in the control and CHD groups, respectively. Binary logistic regression analysis determined as risk factors for CKD in CHD patients: age [1.54 (1.04–1.28), p = 0.009], dyslipidemia [19.8 (1.35–301.1), p = 0.031], low iron concentration [0.96 (0.96–0.93), p = 0.048], cyanosis [25.7 (1.60–411.8), p = 0.022], and Down syndrome [46.8 (8.09–2710), p = 0.003]. During a follow-up time of 6.8 (1.2–10.5) years, cardiovascular mortality occurred in 31 patients with CHD showing, through the Kaplan–Meier test, a worse outcome among patients with CKD (p < 0.05) as was also seen in the univariate Cox regression survival analysis. However, after adjusting for other variables, this significance was lost, with age remaining as the unique independent prognostic factor. Conclusions: The prevalence of CKD was much higher in patients with CHD than in the control group; age, cyanosis, and Down syndrome were the predictors of a higher risk of CKD among CHD patients. Although CKD was associated with worse survival in CHD patients, only age was identified as an independent prognostic factor for cardiovascular mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Clinical profiles and patterns of kidney disease progression in C3 glomerulopathy

Author

Instituto de Salud Carlos III, European Commission, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Cavero, Teresa [0000-0001-5187-9906], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Allende, Natalia [0000-0001-9857-793X], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Rivas, Begoña [0000-0002-5886-9943], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], Miquel, Rosa [0000-0002-0298-7342], Mon, Carmen [0000-0001-9081-8428], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Rivas, Begoña, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, Instituto de Salud Carlos III, European Commission, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Cavero, Teresa [0000-0001-5187-9906], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Allende, Natalia [0000-0001-9857-793X], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Rivas, Begoña [0000-0002-5886-9943], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], Miquel, Rosa [0000-0002-0298-7342], Mon, Carmen [0000-0001-9081-8428], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Rivas, Begoña, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, and Praga, Manuel

Abstract

Background C3 glomerulopathy is a rare kidney disease, which makes it difficult to collect large cohorts of patients to better understand its variability. The aims of this study were to describe the clinical profiles and patterns of progression of kidney disease., Methods This was a retrospective, observational cohort study. Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled. Study population was divided into clinical profiles by combining the following predictors: eGFR under/above 30 ml/min per 1.73 m2, proteinuria under/above 3.5 g/d, and histologic chronicity score under/above 4. The change in eGFR and proteinuria over time was evaluated in a subgroup with consecutive measurements of eGFR and proteinuria., Results One hundred and fifteen patients with a median age of 30 years (interquartile range 19–50) were included. Patients were divided into eight clinical profiles. Kidney survival was significantly higher in patients with a chronicity score <4 and proteinuria <3.5 g/d, both in those presenting with an eGFR under/above 30 ml/min per 1.73 m2. The median eGFR slope of patients who reached kidney failure was −6.5 ml/min per 1.73 m2 per year (interquartile range −1.6 to −17). Patients who showed a reduction in proteinuria over time did not reach kidney failure. On the basis of the rate of eGFR decline, patients were classified as faster eGFR decline (≥5 ml/min per 1.73 m2 per year), slower (<5 ml/min per 1.73 m2 per year), and those without decline. A faster eGFR decline was associated with higher probability of kidney failure., Conclusions Kidney survival is significantly higher in patients with a chronicity score <4 and proteinuria <3.5 g/d regardless of baseline eGFR, and a faster rate of decline in eGFR is associated with higher probability of kidney failure.

Published
2023

15. Determinants of Favourable Outcome Among Adults with Active Thyroid Eye Disease: The Remarkable Role of Long-Duration Treatment Approaches

Author

Rutllan-Civit, Joaquim, primary, Rodríguez-González, Fayna, additional, Salas-Salas, Bárbara, additional, Ferrera, Laura, additional, Juan, Lucía, additional, Cabrera, Raquel, additional, Lloret, Marta, additional, Medina-Rivero, Francisco, additional, González-Martín, Jesús-María, additional, and Pablos-Velasco, Pedro De, additional

Published
2024
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18. Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©.

Author

Pato-Cour, Esperanza, Borrego-Sanz, Lara, Domínguez-Álvaro, Marta, Sánchez-Alonso, Fernando, Rodríguez-González, Fayna, Tejera-Santana, Marta, Esteban-Ortega, Mar, García-Lozano, Isabel, Martínez-Costa, Lucia, González-Ocampo, Samuel, Sainz-de-la-Maza, Maite, Moll-Udina, Aina, Plaza, Zulema, Fonollosa, Alejandro, Artaraz, Joseba, Díaz-Valle, Teresa, Gurrea-Almela, Maria, Díaz-Valle, David, and Méndez-Fernández, Rosalía

Published
2024
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19. Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©.

Author

Pato-Cour, Esperanza, Borrego-Sanz, Lara, Domínguez-Álvaro, Marta, Sánchez-Alonso, Fernando, Rodríguez-González, Fayna, Tejera-Santana, Marta, Esteban-Ortega, Mar, García-Lozano, Isabel, Martínez-Costa, Lucia, González-Ocampo, Samuel, Sainz-de-la-Maza, Maite, Moll-Udina, Aina, Plaza, Zulema, Fonollosa, Alejandro, Artaraz, Joseba, Díaz-Valle, Teresa, Gurrea-Almela, Maria, Díaz-Valle, David, and Méndez-Fernández, Rosalía

Subjects
INTER-observer reliability, IRIDOCYCLITIS, INTRACLASS correlation, TRIAL practice
Abstract

Introduction: This was a multicenter, prospective, longitudinal, observational study involving eight Spanish tertiary hospitals to determine the interobserver reliability of an uveitis disease activity index, (UVEDAI) and assess its sensitivity to change in patients with receiving pharmacologic treatment. Methods: Patients aged ≥ 18 years diagnosed with active noninfectious uveitis were included. A complete baseline assessment was performed by two ophthalmologists who determined ocular inflammatory activity using the UVEDAI index independently of each other. The principal ophthalmologist made a new visit at 4 weeks to determine the change in inflammatory activity. The interobserver reliability analysis was performed by calculating the intraclass correlation coefficient (ICC), with the values of the variables and the UVEDAI obtained by both ophthalmologists in the more active eye at the baseline visit. Sensitivity to change in the UVEDAI index was assessed at 4 weeks from the start of pharmacologic treatment by determining the clinically relevant change, defined as a change in UVEDAI of ≥ 0.8 points over baseline. The mean change between both measures was compared using the repeated-measures t-test. Results: A total of 111 patients were included. In the interobserver reliability analysis, the ICC for the UVEDAI value was 0.9, and, when compared with the mean UVEDAI values obtained by the ophthalmologists, no statistically significant differences were found (p value > 0.05). As for the sensitivity to change in UVEDAI, statistically significant differences (p value = 0.00) were found for the mean values of the index compared with baseline. In all cases, the index value decreased by > 1 point at the 4-week visit. Conclusions: The interobserver reliability of the UVEDAI was high in the total sample. Furthermore, the index was sensitive in determining the change in inflammatory activity after treatment. We believe that UVEDAI is a disease activity index that enables objective comparison of results in clinical practice and trials. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Clinical profiles and patterns of kidney disease progression in C3 glomerulopathy

Author

Caravaca-Fontán, Fernando, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Rivas, Begoña, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, Instituto de Salud Carlos III, European Commission, Red de Investigación Renal (España), Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Ariceta, Gema, Quintana, Luis F., Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Fernández-Juárez, Gema, Pérez de José, Ana, Pérez Gómez, Vanessa, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rivas, Begoña, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, Martín-Penagos, L., Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, and Praga, Manuel

Abstract

14 p.-4 fig.-3 tab., Background C3 glomerulopathy is a rare kidney disease, which makes it difficult to collect large cohorts of patients to better understand its variability. The aims of this study were to describe the clinical profiles and patterns of progression of kidney disease., Methods This was a retrospective, observational cohort study. Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled. Study population was divided into clinical profiles by combining the following predictors: eGFR under/above 30 ml/min per 1.73 m2, proteinuria under/above 3.5 g/d, and histologic chronicity score under/above 4. The change in eGFR and proteinuria over time was evaluated in a subgroup with consecutive measurements of eGFR and proteinuria., Results One hundred and fifteen patients with a median age of 30 years (interquartile range 19–50) were included. Patients were divided into eight clinical profiles. Kidney survival was significantly higher in patients with a chronicity score, Conclusions Kidney survival is significantly higher in patients with a chronicity score, Work in this study was supported by the Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (ISCIII/FEDER) grant PI16/01685 and PI19/1624, and Red de Investigación Renal (RedInRen) (RD12/0021/0029) (to MP), the Autonomous Region of Madrid (S2017/BMD-3673) (to MP). SRdeC is supported by Ministerio de Economia y Competitividad grant PID2019-104912RB-I00 y Autonomous Region of Madrid grant S2017/BMD-3673.

Published
2023

22. Development and validation of a nomogram to predict kidney survival at baseline in patients with C3 glomerulopathy

Author

Instituto de Salud Carlos III, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Cavero, Teresa [0000-0001-5187-9906], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Allende, Natalia [0000-0001-9857-793X], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], Mon, Carmen [0000-0001-9081-8428], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Rivero, Marta, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, Instituto de Salud Carlos III, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Cavero, Teresa [0000-0001-5187-9906], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Allende, Natalia [0000-0001-9857-793X], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], Mon, Carmen [0000-0001-9081-8428], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Rivero, Marta, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, and Praga, Manuel

Abstract

Background: C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It is often challenging to accurately predict in clinical practice the individual kidney prognosis at baseline. We herein sought to develop and validate a prognostic nomogram to predict long-term kidney survival., Methods: We conducted a retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. The dataset was randomly divided into a training group (n = 87) and a validation group (n = 28). The least absolute shrinkage and selection operator (LASSO) regression was used to screen the main predictors of kidney outcome and to build the nomogram. The accuracy of the nomogram was assessed by discrimination and risk calibration in the training and validation sets., Results: The study group comprised 115 patients, of whom 46 (40%) reached kidney failure in a median follow-up of 49 months (range 24–112). No significant differences were observed in baseline estimated glomerular filtration rate (eGFR), proteinuria or total chronicity score of kidney biopsies, between patients in the training versus those in the validation set. The selected variables by LASSO were eGFR, proteinuria and total chronicity score. Based on a Cox model, a nomogram was developed for the prediction of kidney survival at 1, 2, 5 and 10 years from diagnosis. The C-index of the nomogram was 0.860 (95% confidence interval 0.834–0.887) and calibration plots showed optimal agreement between predicted and observed outcomes., Conclusions: We constructed and validated a practical nomogram with good discrimination and calibration to predict the risk of kidney failure in C3 glomerulopathy patients at 1, 2, 5 and 10 years.

Published
2022

23. Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis

Author

Dermatología, oftalmología y otorrinolaringología, Dermatologia, oftalmologia eta otorrinolaringologia, Pato Cour, Esperanza, Martín Martínez, Auxiliadora, Borrego Sanz, Lara, Martínez Costa, Lucía, Esteban Ortega, Mar, Sánchez Costa, Jesús T., Cordero Coma, Miguel, Fonollosa Calduch, Alejandro, Díaz Valle, Teresa, Rodríguez González, Fayna, Sainz de la Mata, Maite, Díaz Valle, David, González Ocampo, Samuel, López Sierra, Sara, García Lozano, Isabel, Garzo García, Irene, Artaraz Beobide, Joseba Iñaki, Gurrea Almela, María, Tejera, Marta, Moll Udina, Aina, Valls Pascual, Elia, Muñoz Fernández, Santiago, Méndez Fernández, Rosalía, Dermatología, oftalmología y otorrinolaringología, Dermatologia, oftalmologia eta otorrinolaringologia, Pato Cour, Esperanza, Martín Martínez, Auxiliadora, Borrego Sanz, Lara, Martínez Costa, Lucía, Esteban Ortega, Mar, Sánchez Costa, Jesús T., Cordero Coma, Miguel, Fonollosa Calduch, Alejandro, Díaz Valle, Teresa, Rodríguez González, Fayna, Sainz de la Mata, Maite, Díaz Valle, David, González Ocampo, Samuel, López Sierra, Sara, García Lozano, Isabel, Garzo García, Irene, Artaraz Beobide, Joseba Iñaki, Gurrea Almela, María, Tejera, Marta, Moll Udina, Aina, Valls Pascual, Elia, Muñoz Fernández, Santiago, and Méndez Fernández, Rosalía

Abstract

Introduction Uveitis is the inflammation of the middle layer of the eye, the uvea, and is a major cause of blindness. None of the instruments used in clinical practice are, in themselves, sufficient to evaluate the course of uveitis. Therefore, it is necessary to develop instruments enabling standardized measurement of inflammatory activity. We developed a composite disease activity index for patients with uveitis known as UVEDAI, which considers the overall activity of the eye. The objective of this study was to validate the composite index of ocular inflammation, UVEDAI. Methods A multicenter cross-sectional study involving eight Spanish tertiary hospitals. Sixty-two patients aged ≥ 18 years with acute uveitis were recruited. Participants gave informed consent before participating in the study. A full ophthalmological examination was performed by two ophthalmologists to determine inflammatory activity: one used the UVEDAI score and the other used clinical judgment. The ophthalmologists did not share their findings with each other to avoid introducing bias into the analysis. Construct validity was established by means of factor analysis. The criterion validity of the index was determined using an ordinal multivariate regression model, in which the dependent variable was the degree of uveal inflammation (mild, moderate, or high/severe). Cut-off points were determined for the UVEDAI and for the receiver operating characteristic (ROC) curves. Results Sixty-two patients were included. Total variance with the three components accounted for 80.32% of the construct validity. Each of the three components identified one type of eye involvement. The discriminatory capacity of UVEDAI was 0.867 (95% CI 0.778; 0.955 p < 0.001) for mild versus moderate–high and 0.946 (95% CI 0.879; 1.000 p < 0.001) for high versus mild–moderate. Conclusions The variables included in UVEDAI enable ocular inflammatory activity to be described with a high degree of accuracy. The index may be used t

Published
2023

24. Sodium-glucose cotransporter 2 inhibition in primary and secondary glomerulonephritis.

Author

Caravaca-Fontán, Fernando, Stevens, Kate, Padrón, Maite, Huerta, Ana, Montomoli, Marco, Villa, Juan, González, Fayna, Vega, Cristina, Mendoza, Manuel López, Fernández, Loreto, Shabaka, Amir, Rodríguez-Moreno, Antolina, Martín-Gómez, Adoración, Labrador, Pedro J, Andújar, Alicia Molina, Soler, M Carmen Prados, Martín-Penagos, Luis, Yerovi, Estefanía, Zahonero, Laura Medina, and Flor, José Carlos De La

Subjects
GLUCOSE transporters, SODIUM-glucose cotransporters, SODIUM-glucose cotransporter 2 inhibitors, NEPHRITIS, GLOMERULAR filtration rate, GLOMERULONEPHRITIS, BODY mass index, KIDNEY glomerulus diseases
Abstract

Background The role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the management glomerular/systemic autoimmune diseases with proteinuria in real-world clinical settings is unclear. Methods This is a retrospective, observational, international cohort study. Adult patients with biopsy-proven glomerular diseases were included. The main outcome was the percentage reduction in 24-h proteinuria from SGLT2i initiation to 3, 6, 9 and 12 months. Secondary outcomes included percentage change in estimated glomerular filtration rate (eGFR), proteinuria reduction by type of disease and reduction of proteinuria ≥30% from SGLT2i initiation. Results Four-hundred and ninety-three patients with a median age of 55 years and background therapy with renin–angiotensin system blockers were included. Proteinuria from baseline changed by –35%, –41%, –45% and –48% at 3, 6, 9 and 12 months after SGLT2i initiation, while eGFR changed by –6%, –3%, –8% and –10.5% at 3, 6, 9 and 12 months, respectively. Results were similar irrespective of the underlying disease. A correlation was found between body mass index (BMI) and percentage proteinuria reduction at last follow-up. By mixed-effects logistic regression model, serum albumin at SGLT2i initiation emerged as a predictor of ≥30% proteinuria reduction (odds ratio for albumin <3.5 g/dL, 0.53; 95% CI 0.30–0.91; P  = .02). A slower eGFR decline was observed in patients achieving a ≥30% proteinuria reduction: –3.7 versus –5.3 mL/min/1.73 m2/year (P  = .001). The overall tolerance to SGLT2i was good. Conclusions The use of SGLT2i was associated with a significant reduction of proteinuria. This percentage change is greater in patients with higher BMI. Higher serum albumin at SGLT2i onset is associated with higher probability of achieving a ≥30% proteinuria reduction. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Effectiveness of mycophenolate mofetil in C3 glomerulonephritis

Author

Rabasco, Cristina, Cavero, Teresa, Román, Elena, Rojas-Rivera, Jorge, Olea, Teresa, Espinosa, Mario, Cabello, Virginia, Fernández-Juarez, Gema, González, Fayna, Ávila, Ana, Baltar, José María, Díaz, Montserrat, Alegre, Raquel, Elías, Sandra, Antón, Monserrat, Frutos, Miguel Angel, Pobes, Alfonso, Blasco, Miguel, Martín, Francisco, Bernis, Carmen, Macías, Manuel, Barroso, Sergio, de Lorenzo, Alberto, Ariceta, Gema, López-Mendoza, Manuel, Rivas, Begoña, López-Revuelta, Katia, Campistol, José María, Mendizábal, Santiago, de Córdoba, Santiago Rodríguez, and Praga, Manuel

Published
2015
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27. Longitudinal change in proteinuria and kidney outcomes in C3 glomerulopathy

Author

Instituto de Salud Carlos III, European Commission, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Cabello, Virginia [0000-0002-0877-5498], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Cabello, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, Cano-Megías, Marta, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, Spanish Group for the Study of Glomerular Diseases (GLOSEN), Instituto de Salud Carlos III, European Commission, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Cabello, Virginia [0000-0002-0877-5498], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Cabello, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, Cano-Megías, Marta, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, and Spanish Group for the Study of Glomerular Diseases (GLOSEN)

Abstract

Introduction: The association between a change in proteinuria over time and its impact in kidney prognosis has not been analyzed in C3 glomerulopathy. This study aims to investigate the association between the longitudinal change in proteinuria and the risk of kidney failure., Methods: Retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases (GLOSEN). Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled. A joint modeling of linear mixed-effects models was applied to assess the underlying trajectory of a repeatedly measured proteinuria, and a Cox model to evaluate the association of this trajectory with the risk of kidney failure., Results: The study group consisted of 85 patients, 70 C3 glomerulonephritis and 15 dense deposit disease, with a median age of 26 years (range 13-41). During a median follow-up of 42 months, 25 patients reached kidney failure. The longitudinal change in proteinuria showed a strong association with the risk of this outcome, with a doubling of proteinuria levels resulting in a 2.5-fold increase of the risk. A second model showed that a ≥ 50% proteinuria reduction over time was significantly associated with a lower risk of kidney failure (HR: 0.79; 95% CI : 0.56-0.97; p < 0.001). This association was also found when the ≥50% proteinuria reduction was observed within the first 6 and 12 months of follow-up., Conclusion: The longitudinal change in proteinuria is strongly associated with the risk of kidney failure. The change in proteinuria over time can provide clinicians a dynamic prediction of kidney outcomes.

Published
2021

28. Longitudinal change in proteinuria and kidney outcomes in C3 glomerulopathy

Author

Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Cabello, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Espinosa, Natalia, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Draibe, Juliana, Cano-Megías, Marta, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, Spanish Group for the Study of Glomerular Diseases (GLOSEN), Instituto de Salud Carlos III, European Commission, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Cabello, Virginia [0000-0002-0877-5498], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Praga, Manuel [0000-0001-9270-1071], Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Cabello, Virginia, Ariceta, Gema, Quintana, Luis F., Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Fernández-Juárez, Gema, Pérez de José, Ana, Pérez Gómez, Vanessa, Sánchez de la Nieta, María Dolores, Olea, Teresa, Melgosa, Marta, Huerta, Ana, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, Martín-Penagos, L., Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, and Praga, Manuel

Subjects
Nephrology, Adult, medicine.medical_specialty, Adolescent, Glomerulonephritis, Membranoproliferative, 030232 urology & nephrology, Kidney failure, 030204 cardiovascular system & hematology, Lower risk, Kidney, 03 medical and health sciences, Joint models, Young Adult, 0302 clinical medicine, Glomerulonephritis, Glomerulopathy, Internal medicine, medicine, Humans, C3 glomerulopathy, Retrospective Studies, Transplantation, Proteinuria, business.industry, Proportional hazards model, urogenital system, Complement C3, medicine.disease, medicine.anatomical_structure, Kidney Failure, Chronic, medicine.symptom, business, Cohort study
Abstract

11 p.-4 fig.-4 tab., Introduction: The association between a change in proteinuria over time and its impact in kidney prognosis has not been analyzed in C3 glomerulopathy. This study aims to investigate the association between the longitudinal change in proteinuria and the risk of kidney failure., Methods: Retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases (GLOSEN). Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled. A joint modeling of linear mixed-effects models was applied to assess the underlying trajectory of a repeatedly measured proteinuria, and a Cox model to evaluate the association of this trajectory with the risk of kidney failure., Results: The study group consisted of 85 patients, 70 C3 glomerulonephritis and 15 dense deposit disease, with a median age of 26 years (range 13-41). During a median follow-up of 42 months, 25 patients reached kidney failure. The longitudinal change in proteinuria showed a strong association with the risk of this outcome, with a doubling of proteinuria levels resulting in a 2.5-fold increase of the risk. A second model showed that a ≥ 50% proteinuria reduction over time was significantly associated with a lower risk of kidney failure (HR: 0.79; 95% CI : 0.56-0.97; p < 0.001). This association was also found when the ≥50% proteinuria reduction was observed within the first 6 and 12 months of follow-up., Conclusion: The longitudinal change in proteinuria is strongly associated with the risk of kidney failure. The change in proteinuria over time can provide clinicians a dynamic prediction of kidney outcomes., This study was supported by the Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (ISCIII/FEDER) grant PI16/01685 and PI19/1624, and Red de Investigación Renal (RedInRen) (RD12/0021/0029) (to M.P.), the Autonomous Region of Madrid (S2017/BMD-3673) (to M.P.); E.G.d.J. was supported by the Spanish ‘Ministerio de Ciencia, Innovación y Universidades’ (RYC-2013-13395 and RTI2018-095955-B-100); S.R.d.C. was supported by Ministerio de Economía y Competitividad/FEDER grant SAF2015-66287R and Autonomous Region of Madrid grant S2017/BMD3673.

Published
2021

29. A Common Variant at the 3'untranslated Region of the CCL7 Gene (rs17735770) Is Associated With Decreased Susceptibility to Coronary Heart Disease

Author

Medina-Gil, José María, primary, Pérez-García, Ana, additional, Saavedra-Santana, Pedro, additional, Díaz-Carrasco, Asunción, additional, Martínez-Quintana, Efrén, additional, Rodríguez-González, Fayna, additional, Ramírez, Cristina M., additional, Riaño, Marta, additional, Garay-Sánchez, Paloma, additional, and Tugores, Antonio, additional

Published
2022
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30. Development and validation of a nomogram to predict kidney survival at baseline in patients with C3 glomerulopathy

Author

Caravaca-Fontán, Fernando, primary, Rivero, Marta, additional, Cavero, Teresa, additional, Díaz-Encarnación, Montserrat, additional, Cabello, Virginia, additional, Ariceta, Gema, additional, Quintana, Luis F, additional, Marco, Helena, additional, Barros, Xoana, additional, Ramos, Natalia, additional, Rodríguez-Mendiola, Nuria, additional, Cruz, Sonia, additional, Fernández-Juárez, Gema, additional, Rodríguez, Adela, additional, Pérez de José, Ana, additional, Rabasco, Cristina, additional, Rodado, Raquel, additional, Fernández, Loreto, additional, Pérez-Gómez, Vanessa, additional, Ávila, Ana, additional, Bravo, Luis, additional, Espinosa, Natalia, additional, Allende, Natalia, additional, Sanchez de la Nieta, Maria Dolores, additional, Rodríguez, Eva, additional, Olea, Teresa, additional, Melgosa, Marta, additional, Huerta, Ana, additional, Miquel, Rosa, additional, Mon, Carmen, additional, Fraga, Gloria, additional, de Lorenzo, Alberto, additional, Draibe, Juliana, additional, González, Fayna, additional, Shabaka, Amir, additional, López-Rubio, Maria Esperanza, additional, Fenollosa, María Ángeles, additional, Martín-Penagos, Luis, additional, Da Silva, Iara, additional, Alonso Titos, Juana, additional, Rodríguez de Córdoba, Santiago, additional, Goicoechea de Jorge, Elena, additional, and Praga, Manuel, additional

Published
2022
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31. Mycophenolate Mofetil in C3 glomerulopathy and pathogenic drivers of the disease

Author

Instituto de Salud Carlos III, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Lucientes, Laura [0000-0001-5596-370X], Cavero, Teresa [0000-0001-5187-9906], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Lumbreras, Javier [0000-0003-1855-0724], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Praga, Manuel [0000-0001-9270-1071], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Lucientes, Laura, Cavero, Teresa, Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Lumbreras, Javier, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Cano-Megías, Marta, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, Instituto de Salud Carlos III, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Lucientes, Laura [0000-0001-5596-370X], Cavero, Teresa [0000-0001-5187-9906], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Lumbreras, Javier [0000-0003-1855-0724], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Praga, Manuel [0000-0001-9270-1071], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Lucientes, Laura, Cavero, Teresa, Cabello-Chaves, Virginia, Ariceta, Gema, Quintana, Luis F., Marco, Helena, Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Cruz, Sonia, Fernández-Juárez, Gema, Rodríguez, Adela, Pérez de José, Ana, Rabasco, Cristina, Rodado, Raquel, Fernández, Loreto, Pérez Gómez, Vanessa, Ávila, Ana, Bravo, Luis, Lumbreras, Javier, Allende, Natalia, Sánchez de la Nieta, María Dolores, Rodríguez, Eva, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Miquel, Rosa, Mon, Carmen, Fraga, Gloria, de Lorenzo, Alberto, Cano-Megías, Marta, González, Fayna, Shabaka, Amir, López-Rubio, María Esperanza, Fenollosa, María Ángeles, Martín-Penagos, L., Da Silva, Iara, Alonso Titos, Juana, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, and Praga, Manuel

Abstract

BACKGROUND AND OBJECTIVES: C3 glomerulopathy is a complement-mediated disease arising from abnormalities in complement genes and/or antibodies against complement components. Previous studies showed that treatment with corticosteroids plus mycophenolate mofetil (MMF) was associated with improved outcomes, although the genetic profile of these patients was not systematically analyzed. This study aims to analyze the main determinants of disease progression and response to this therapeutic regimen., DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective, multicenter, observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. Patients diagnosed with C3 glomerulopathy (n=81) or dense deposit disease (n=16) between January 1995 and March 2018 were enrolled. Multivariable and propensity score matching analyses were used to evaluate the association of clinical and genetic factors with response to treatment with corticosteroids and MMF as measured by proportion of patients with disease remission and kidney survival (status free of kidney failure)., RESULTS: The study group comprised 97 patients (84% C3 glomerulopathy, 16% dense deposit disease). Forty-two patients were treated with corticosteroids plus MMF, and this treatment was associated with a higher rate of remission and lower probability of kidney failure (79% and 14%, respectively) compared with patients treated with other immunosuppressives (24% and 59%, respectively), or ecluzimab (33% and 67%, respectively), or conservative management (18% and 65%, respectively). The therapeutic superiority of corticosteroids plus MMF was observed both in patients with complement abnormalities and with autoantibodies. However, patients with pathogenic variants in complement genes only achieved partial remission, whereas complete remissions were common among patients with autoantibody-mediated forms. The main determinant of no remission was baseline proteinuria. Relapses occurred after treatment discontinuation in 33% of the patients who had achieved remission with corticosteroids plus MMF, and a longer treatment length of MMF was associated with a lower risk of relapse., CONCLUSIONS: The beneficial response to corticosteroids plus MMF treatment in C3 glomerulopathy appears independent of the pathogenic drivers analyzed in this study.

Published
2020

34. Blood test assessment of liver ultrasound findings in patients with Fontan surgery

Author

Martínez-Quintana, Efrén and Rodríguez-González, Fayna

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, cardiovascular system, Original Article, cardiovascular diseases, digestive system diseases
Abstract

Hepatic complications are common in patients with Fontan surgery. The objective of this observational study is to compare demographic, clinical and blood test data in patients older than 14 years old with a Fontan procedure (cases) and asymptomatic patients with single non-operated restrictive ventricular septal defect (VSD) (controls) and to determine whether there are differences in blood collection and liver disease scores according to the liver ultrasound findings in the group of Fontan patients. The liver findings were classified as mild (normal or heterogeneous echogenicity) and significant (nodular surface, small hyperechoic nodules or hepatocarcinoma). 74 patients (14 patients with a Fontan procedure and 60 patients with a restrictive VSD) were included in the study. Median age was 18 (14-45) years old and 41 patients were males. Fontan patients had significantly lower platelet count, lower mean platelet volume (MPV) and lower glucose levels than patients with single non-operated restrictive VSD. On the contrary, Fontan patients showed higher liver enzymes [aspartate aminotransferase (AST) and alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT)], N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and thyroid-stimulating hormone (TSH) concentrations than patients with restrictive VSD. 4 out of 14 (29%) patients with Fontan operation and significant liver ultrasound findings showed greater number of cardiac surgeries, lower MPV values and higher GGT and TSH levels than Fontan patients with mild findings. In conclusion, Fontan patients showed higher liver enzymes (AST, ALT and GGT) than controls and Fontan patients with significant liver ultrasound findings had higher GGT and TSH concentrations than Fontan patients with mild findings.

Published
2021

35. Mental well-being among patients with congenital heart disease and heart failure during the COVID-19 pandemic

Author

Martínez-Quintana, Efrén, Vega-Acedo, Laura del Carmen, Santana-Herrera, Daniela, Pérez-Acosta, Carolina, Medina-Gil, José María, Muñoz-Díaz, Encarnación, and Rodríguez-González, Fayna

Subjects
Original Article
Abstract

Patients with congenital heart disease (CHD) show increasing survival. We evaluated the influence of COVID-19 confinement on the mental well-being of patients with CHD. Descriptive, cross-sectional, observational epidemiological study in a cohort of 242 patients with CHD over 14 years old recruited consecutively from a single adolescent and adult CHD outpatient unit. Patients were sent an online questionnaire to determine clinical, demographic and the 12-element general health questionnaire (GHQ-12) data during the COVID-19 quarantine. 242 out of 407 (59%) patients with CHD, to whom the questionnaire was sent, responded to the survey. 98 (42%) patients were between 14 and 24 years old and 133 (58%) were over 25 years old. Of the total, 119 (51%) were male. 123 (51%), 88 (36%) and 31 (13%) patients with CHD had mild, moderate, and severe anatomical complexity respectively. 11 (4.5%) out of 242 patients with CC presented heart failure (HF) symptoms, requiring 18% of them admission to the hospital emergency department during the pandemic (P=0.002). In relation to the GHQ-12 questionnaire, patients with CHD and HF enjoyed less their daily activities (81% vs. 51%, P=0.043) and had less self-confidence (46% vs. 18%, P=0.041) than those without HF symptoms. In conclusion, patients with CHD and HF, during the COVID-19 quarantine, presented a lower capacity to enjoy daily activities and self-confidence than CHD without HF symptoms.

Published
2021

38. Quality of Life in Congenital Heart Disease Patients according to Their Anatomical and Physiological Classification.

Author

Martínez-Quintana, Efrén, Estupiñán-León, Hiurma, Rojas-Brito, Ana Beatriz, Déniz-Déniz, Liuva, Barreto-Martín, Alejandro, and Rodríguez-González, Fayna

Subjects
CONGENITAL heart disease, CARDIAC patients, QUALITY of life, LOGISTIC regression analysis, PULMONARY valve
Abstract

Background: Living well is as important as living longer. The objective of this study is to assess quality of life (QoL) in congenital heart disease (CHD) according to current AHA/ACC anatomical and physiological classifi- cation. Methods: Cross-sectional study examining the World Health Organization QoL Bref questionnaire (WHOQoL-Bref) in consecutive outpatient CHD patients from a single unit. Results: 191 CHD patients were studied. Median age was 28 ± 13 years and 59% were male. 44 (23%), 115 (60%) and 33 (17%) CHD patients showed mild, moderate and great anatomical defects respectively while 69 (36%) patients were in physiological Stage A, 27 (14%) in Stage B, 84 (44%) in Stage C and 11 (6%) in Stage D. No significant differences were seen in relation the anatomical classification and the different sections of the WHOQoL-Bref questionnaire. CHD patients in Stages C and D had significant lower physical domain scores than patients in the Stage A (p < 0.05). However, no significant differences were seen in the psychological, social relationships and environmental domains. The binary logistic regression analysis showed that having a higher educational level was a protective factor [OR 0.32 (95% CI, 0.12-0.87), p = 0.026] while being married or cohabit was a risk factor [OR 3.46 (95% CI, 1.13-10.63), p = 0.030] for having a worse rated QoL. Meanwhile, having a worse functional class (NYHA ≥2) [OR 3.44 (95% CI, 1.20-9.81), p = 0.021] was associated with dissatisfaction with health. Conclusion: Patients with advanced physiological stages scored lower on the physiological domain. No statistical significance was seen, according to the anatomical and physiological classification, in the psychological, social relationship and environmental domains. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Cardiogenic shock following blunt chest trauma

Author

Rodríguez-González Fayna and Martínez-Quintana Efrén

Subjects
Aneurysm, blunt cardiac injury, cardiac contusion, cardiac complications, echocardiography, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Cardiac contusion, usually caused by blunt chest trauma, has been recognized with increased frequency over the past decades. Traffic accidents are the most frequent cause of cardiac contusions resulting from a direct blow to the chest. Other causes of blunt cardiac injury are numerous and include violent fall impacts, interpersonal aggression, explosions, and various types of high-risk sports. Myocardial contusion is difficult to diagnose; clinical presentation varies greatly, ranging from lack of symptoms to cardiogenic shock and arrhythmia. Although death is rare, cardiac contusion can be fatal. We present a case of cardiac contusion due to blunt chest trauma secondary to a fall impact, which manifested as cardiogenic shock.

Published
2010

46. Validation of a Histologic Scoring Index for C3 Glomerulopathy

Author

Caravaca-Fontán, Fernando, primary, Trujillo, Hernando, additional, Alonso, Marina, additional, Díaz-Encarnación, Montserrat, additional, Cabello, Virginia, additional, Ariceta, Gema, additional, Quintana, Luis F., additional, Marco, Helena, additional, Barros, Xoana, additional, Ramos, Natalia, additional, Rodríguez-Mendiola, Nuria, additional, Cruz, Sonia, additional, Fernández-Juárez, Gema, additional, Rodríguez, Eva, additional, de la Cerda, Francisco, additional, Pérez de José, Ana, additional, López, Inmaculada, additional, Fernández, Loreto, additional, Pérez Gómez, Vanessa, additional, Ávila, Ana, additional, Bravo, Luis, additional, Lumbreras, Javier, additional, Allende, Natalia, additional, Sanchez de la Nieta, Maria Dolores, additional, Olea, Teresa, additional, Melgosa, Marta, additional, Huerta, Ana, additional, Miquel, Rosa, additional, Mon, Carmen, additional, Fraga, Gloria, additional, de Lorenzo, Alberto, additional, Draibe, Juliana, additional, González, Fayna, additional, Shabaka, Amir, additional, Illescas, Maria Luisa, additional, Calvo, Consuelo, additional, Oviedo, Victoria, additional, Da Silva, Iara, additional, Goicoechea de Jorge, Elena, additional, Caravaca, Francisco, additional, Praga, Manuel, additional, Cavero, Teresa, additional, Sevillano, Ángel, additional, Gutiérrez, Eduardo, additional, Morales, Enrique, additional, González, Lucia, additional, Camacho Galán, Rafael, additional, Gabaldón Domínguez, Alejandra, additional, Garrido, Marta, additional, Navarro, Alexandra, additional, Cortés, José Antonio, additional, Pascual Martin, Alejando, additional, Pérez-Ebri, M. Luisa, additional, Cabrera-Pérez, Rocío, additional, Panizo Santos, Ángel, additional, Yébenes Gregorio, Laura, additional, García Fernández, Maria Eugenia, additional, Gimeno, Javier, additional, Cannata Ortiz, Pablo, additional, Roselló Sastre, Esther, additional, Saiz, Ana, additional, Salido Ruiz, Eduardo, additional, Rodríguez, Rosa, additional, Corbacho Cuevas, Cesáreo, additional, Crespo, Francisco Díaz, additional, Arce, Yolanda, additional, Garcia-Cuerva Calvar, Maria Soledad, additional, Saus, Carles, additional, Guerrero Márquez, Carmen, additional, García-Herrera, Adriana, additional, Gomà Gallego, Montserrat, additional, López Álvarez, Dolores, additional, Meléndez Muñoz, Cristina, additional, Centeno, Macarena, additional, Ferri Ñíguez, Belén, additional, Mosquera Reboredo, Juan, additional, Vázquez Martul, Eduardo, additional, and Pérez Gutiérrez, Sofía, additional

Published
2021
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