285 results on '"González‐Duarte, Alejandra"'
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2. Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study
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Abraham, Rachael, Ager, Arijan, Aguilar, Franchesca A., Ahmadi-Izad, Ghazal, Ahmed, Dilshad R., Alvarez, Alicarmen, Anderson, Blake, Asencios, Walter D., Atha, Mary, Beaty, Casey L., Bedi, Brahmchetna, Berry, Jasmine A., Boone, Donchel, Bower, Mary, Bremner, James D., Brent, Corbin, Brown-Smith, Ke'Ara, Bull, Rachel, Bush, Patricia A., Capo, Gustavo, Carl-Igwe, Kelechi, Chitadze, Calista, Chukwumerije, Nachi, Clyburn, Erna, Collins, Shelby, Costello, Julie, Couture, Grace, Craft, Angel, Cribbs, Sushma K., Cui, Xiangqin, Dandy, Annette, Rio, Carlos del, Jasarevic, Rijalda, Detelich, Joshua F., Dixon, Cartia, Dow, Jeanne, Doyle, D'Andrea, Elchommali, Jannah, Ibeawuchi, Carmel, Elsey, Imani, Fineman, Rebecca, Francis, Anyssa G., Franks, Nicole, Gallini, Julia, Gander, Jennifer C., Gray, Natalie, Grimes, Ash, Gutter, Evan, Han, Jenny E., Hang, Tina P., Harding, Jess, Hernandez, Liliana, Hewitt, Lauren N., Holloway, Carla, Hudgins, Alex F., Huerta, Christopher, Ifejika, Cynthia, Ingram, 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Alejandra L., Illendula, Sai D., Ismail, Nahed, Jain, Akash, Jennette, Kyle J., Kadubek, Grace, Kent, Denise, Kotini-Shah, Pavitra, Kelly, Sara W., Kent, Denise A., Kim, Keri S., Kindred, Elijah, Klein, Jonathan D., Krishnan, Jerry A., Large, Lucia, Lash, James ., Lin, Janet Y., Lu, Jun, Mahamed, Abeer M., Maholovich, Phoebe, Malchenko, Sergey, Martinez, Miriam, Mauntel-Medici, Cammeo, Madineni, Abhigna, McCauley, Mark, Menchaca, Martha, Mermelstein, Robin, Moreno, David J., Morrissy, Liam, Muramatsu, Naoko, Musick, Hugh, Noland, Seth, Norwick, Lourdes, Novak, Richard M., Olds, Lela, Ortiz, Marilyn, Patel, Khushboo, Perez, Nicolas L., Pliskin, Neil H., Pope, Sam, Prabhakar, Bellur S., Prasad, Bharati, Predki, Barbara, Prendergast, Heather M., Quigley, John G., Ramchandran, Ramaswamy, Ramirez, Ana, Rappe, Sarah, Rehman, Jalees, Rolon, Cesar, Rowley, Matthew, Rudraraju, Gowrisree, Rutherfoord, Melissa, Sader, Samer B., Sculley, Jennifer A., Smith-Mack, Jerisha, Swearingen, Peyton, Stewart de Ramirez, Sarah A., Sudhindra, Praveen, Sun, Jun, Tartt, Nancy, Terlinde, Tracy, Thompson, Tiffany, Vanden Hoek, Terry L., Kelly, Sara Warfield, Villanueva, Laura, Welter, Hannah, Woolley, Brittany, Yazici, Cemal, Charney, Alexander W., Kovatch, Patricia, Merad, Miriam, Nadkarni, Girish N., Wisnivesky, Juan P., Aberg, Judith A., Ascolillo, Steven, Assenso, Esther, Bagiella, Emilia, Bartram, Logan, Becker, Jacqueline, Beckmann, Noam D., Bendl, Ashley, Chen, Benjamin K., Civil, Alyssa, Dhar, Kaberi, Evo-Ortega, Lorraine, Fierer, Daniel, Gallagher, Emily J., Garcia-Sastre, Adolfo, Gnjatic, Sacha, Guliyeva, Sabina, Harvey-Ingram, Lori, Herrera-Moreno, Julia, Hill, Matthew, Horowitz, Carol R., Jackson, Rachel, Kastrat, Din, Lala-Trindade, Anu, Lin, Jenny, Macaluso, Nick, Marcon, Kathryn, Meyer, Dara, Morinigo, Janice, Natelson, Benjamin H., Nussenzweig, Maya, Padua, Tiffani, Putrino, David, Quazi, Nawreen, Ramos, Michelle, Richardson, Lynne, Russo, Scott, Seifert, Alan C., Serri, Abdullah, Walker, Jordan, Yee, Michell, Adolphi, Natalie L., Alekhina, Natalya, Archuleta, David A., Barlocker, Jackson, Bateman, Lucinda, Bradfute, Steven B., Brito, Rebecca, Bryan, Tanner W., Buck, Kaitlin E., Davis, Debra, Deakyne Davies, Sara J., Decker, Lauren A., Elifritz, Jamie, Erlandson, Kristine M., Facelli, Julio C., Fudge, Harrison Z., Tran, Huong, Pitch, Chloe, Feuerriegel, Elen M., Ford, Isaac, Friedman, Naomi P., Garcia-Soberanez, Noella D., Gardner, Edward M., Stringham, Caitlyn, Ling, Leah, Gebremariam, Tewodros H., Gentry, Frederick D., Gouripeddi, Ramkiran, Graham, Paige, Gronert, Eve G., Harkins, Michelle S., Hawkins, Kellie L., Hess, Rachel, Johnny, Jace D., Johnson, Brandon M., Jolley, Sarah E., Lloyd, Jennifer, Ludwig, Katelyn R., Martinez, Noah I., McCandless, Sean A., Montoya, Lorenzo A., Oakes, Judy L., Parada, Alisha N., Quinn, Davin K., Raissy, Hengameh, Ramos, Alfredo, Reid, Kayleigh M., Reusch, Jane E., Sheehan, Elyce B., Sokol, Ron J., Treacher, Irena S., Trinity, Joel D., Truong, Dongngan T., West, Shelby C., Molden, Joie, Sharareh, Nasser, Weaver, Lisa J., Spivak, Adam M., Brown, Jeanette P., Shah, Kevin S., Pace, Laura A., Scholand, Mary Beth, Velinder, Matt, Cortez, Melissa, Morimoto, Sarah Shizuko, Vernon, Suzanne D., Lu, Yue, Owen, Megan, Hermansen, Jessica A., Lindsay, Ashton M., Donohue, Dagny K., Garg, Lohit, Wodushek, Thomas, Higgins, Janine, Lockie, Tim, Brightman, Marisa, Thurman, Brook, Powell, Jenny M., Freston, Dylan C., Medina, Juliemar C., Aguirre, Bailee, Anderson, Jeff, Bair, Tami, Bosh, Lindsay, Evans, Lorlie, Garrett, Chase, Harris, Dixie, Herrera, Katherine, Horne, Benjamin D., Juan, James, Knight, Stacey, Knowlton, Kirk, Leither, Lindsay, Maestas, Heather, May, Heidi T., Najarian, Gabriel, Woller, Scott C., Zubal, Shyanne, Jensen, McKenna M., Webb, Tiaura, Iverson, Leslie, Ayache, Mirna, Baloi, Alexis, Barnboym, Emma, Boldt, Nicholas, Bukulmez, Hulya, Chesnick, Hailey, Conrad, Ann, Consolo, Mary, Curtis, Lynette, D’anza, Brian, DiFrancesco, Kathryn, Edminston, Marissa, Eteshola, Ebenezer, Gallagher, Michelle, Gibson, Kelly S., Gordesky, Larraine, Greenwood, Carla, Haghiac, Maricela, Harris, Paul, Hernandez, Carla, Iqbal, Shirin, Kaelber, David C., Kaufman, Elizabeth S., Kennedy, Olivia, Labbato, Danielle, Lengu, Ketrin, Levert, Antonio, Levin, Jennifer, Lowenthal, Rebecca, Mackin, Bridget, Malakooti, Shahdi K., McComsey, Grace A., Minium, Judy, Mouchati, Christian, Oleson, Christine, Pearman, Ann, Hershey, Morgan, Rivera, Amanda, Rodgers, Michael, Rodgers, Theresa, Roy, Arnab, Russ, Kris, Scott, Sarah, Sheth, Niyati, Singer, Nora G., Smith, Beth, Smith, Cheryl, Stancin, Terry, Temple, Daniel, Tribout, Megan, Weinberger, Elisheva, Zhang, David, Zisis, Sokratis N., Atieh, Ornina, Yendewa, George, Baissary, Jhony, Pettinato, KImberly, Lim, Joaquin, Jacob, Joshua, Adams, Cara, Tejani, Viral, Algren, Heather A., Alicic, Radica, Baxter, Joni, Brennan, Conor, Caudill, Antonina, Chen, Peter, Chopra, Tananshi, Chu, Helen Y., Del Alcazar, James, Duven, Alexandria M., Edmark, Rick, Emerson, Sarah, Goldman, Jason D., Gutierrez, Vanessa, Hadlock, Jennifer, Harteloo, Alex, Heath, James R., Hood, Susan, Jackman, Susan, Kaneko, John, Kemp, Megan, Kim, Christina, Kuykendall, Kelli, Li, Sarah, Logue, Jennifer K., Magis, Andrew T., Manner, Paula, Mason, Carly, McCaffrey, Kathryn, McDonald, Connor, McDonald, Dylan, Murray, Kim M., Nackviseth, Callista, Nguyen, Helen, Parimon, Tanyalak, Poussier, Rachel, Rowen, Lee, Satira, Richard, Torbati, Sam, Tuttle, Katherine R., Wallick, Julie A., Yuan, Dan, Watanabe, Kino, Wilcox, Lauren E., Contreras, Fatima, Dahlke, Lea, Gudipudi, Lasya, Modes, Matthew, Muttera, Nicole, Salinas, Nancy, Tadeo, Josie, White, Shane, Alvarado, Stephanie, Anderson, Reed, Arellanes, Azaneth, Barajas, Rose A., Chauhan, Suneet P., Clarke, Geoffrey D., Farner, Cheryl E., Fischer, Melinda S., Goldberg, Mark P., Hasbani, Keren, Hastings, Gabrielyd, Heard, Patricia, Herrera, Italia, Infante, Edgar, Johnson, Hillary, Jones, Johnnie, Kellogg, Dean L., Kraig, Ellen, Longoria, Lisa, Nambiar, Anoop M., Okafor, Emeka, Paredes, Claudia C., Patterson, Thomas F., Patterson, Jan E., Pinones, Alexis, Potter, Jennifer S., Reeves, W.B., Saade, George R., Salehi, Marzieh, Scholler, Irma, Seshadri, Sudha, Shah, Dimpy P., Shah, Pankil, Sharma, Kumar, Sharma, Kavita, Soileau, Bridgette, Solis, Pamela, Stoebner, Carmen, Sullivan, Michael, Taylor, Barbara S., Tragus, Robin, Tsevat, Joel, Verduzco-Gutierrez, Monica, Ahuja, Neera, Blish, Catherine A., Blomkalns, Andra L., Bonilla, Hector, Brotherton, Richard, Clinton, Kimberly, Dingankar, Vaidehi, Geng, Linda N., Go, Minjoung, Haddad, Francois, Jagannathan, Prasanna, Jamero, Christopher, Jee, Kathryn, Jia, Xiaolin K., Khurana, Naresh, Kumar, Andre, Maldonado, Yvonne, Miglis, Mitchell G., O'Conor, Ellen, Olszewski, Kelly, Pathak, Divya, Quintero, Orlando, Scott, Jake, Singh, Upinder, Urdaneta, Alfredo E., Utz, Paul J., Varkey, Mary R., Saperia, Corey, Autry, Lynn, Bime, Christian, Borwege, Sabine, Copeland, Jacquelynn, DiLise-Russo, Marjorie, Ernst, Kacey C., Esquivel, Denise R., Fadden, Susan, Gomez, Isaias, Grischo, Garrett, Hansen, Lillian, Harris, David T., Harris, Stefanie, Hartley, William, Hernandez, Michael, Hillier, Leah, Hsu, Harvey, Hughes, Trina, Ismail, Hira, Iusim, Stephanie, James, Michelle, Kala, Mrinalini, Karnafel, Maria, Kim, Daniel, Knox, Kenneth S., Koleski, Alison, LaFleur, Bonnie, Lambert, Brenda, LaRue, Sicily, Lee-Iannotti, Joyce K., Lieberman, David, Lutrick, Karen, Merchant, Nirav, Morton, Christopher, Mosier, Jarrod M., Murthy, Ganesh, Nikolich, Janko Z., Olorunnisola, Toluwanimi, Parthasarathy, Sairam, Peralta, Jeanette, Pilling, William, Pogreba-Brown, Kristen, Reiman, Eric M., Rischard, Franz P., Ryan, Lee T., Smith, Terry, Snyder, Manuel, Soto, Francisco, Subbian, Vignesh, Suhr, Kyle, Unzek, Samuel, Vadovicky, Sheila, Velarde, Deanna, Veres, Sharry, Wilson, Cathleen, Anderson, Grace, Anglin, Khamal, Argueta, Urania, Asare, Kofi, Buitrago, Melissa, Chang Song, Celina, Clark, Alexus, Conway, Emily, Deeks, Steven G., Del Castillo, Nicole, Deswal, Monika, Durstenfeld, Matthew S., Eilkhani, Elnaz, Eun, Avery, Fehrman, Emily, Figueroa, Tony, Flores, Diana, Grebe, Halle, Henrich, Timothy J., Hoh, Rebecca, Hsue, Priscilla, Huang, Beatrice, Ibrahim, Rania, Kelly, John D., Kerbleski, Marian, Kirtikar, Raushun, Lew, Megan T., Lombardo, James, Lopez, Monica, Luna, Michael, Marquez, Carina, Martin, Jeffrey N., Munter, Sadie, Ngo, Lynn, Peluso, Michael J., Pineda-Ramirez, Jesus, Rhoads, Kim, Rodriguez, Antonio, Romero, Justin, Ryder, Dylan, So, Matthew, Somsouk, Ma, Tai, Viva, Tran, Brandon, Uy, Julian, Valdivieso, Daisy, Verma, Deepshika, Williams, Meghann, Zamora, Andhy, Newman, Lisa T., Abella, Julie, Barnette, Quinn, Bevc, Christine, Beverly, Jennifer, Ceger, Patricia, Croxford, Julie, Enger, Mike, Fain, Katie, Farris, Tonya, Hanlon, Sean, Hines, David, Johnson-Lawrence, Vicki, Jordan, Kevin, Lefebvre, Craig, Linas, Beth, Luukinen, Bryan, Mandal, Meisha, McKoy, Nikki J., Nance, Susan, Pasquarelli, Demian, Quiner, Claire, Sembajwe, Rita, Shaw, Gwendolyn, Thornburg, Vanessa, Tosco, Kendall, Wright, Hannah, Gross, Rachel S., Hochman, Judith S., Horwitz, Leora I., Katz, Stuart D., Troxel, Andrea B., Adler, Lenard, Akinbo, Precious, Almenana, Ramona, Aschalew, Malate, Balick, Lara, Bello, Ola, Bhuiyan, Sultana, Blachman, Nina, Branski, Ryan, Briscoe, Jasmine, Brosnahan, Shari, Bueler, Elliott, Burgos, Yvette, Caplin, Nina, Chaplin, Domonique, Chen, Yu, Cheng, Shen, Choe, Peter, Choi, Jess, Chung, Alicia, Church, Richard, Cobos, Stanley, Croft, Nakia, Irving, Angelique Cruz, Del Boccio, Phoebe, Díaz, Iván, Divers, Jasmin, Doshi, Vishal, Dreyer, Benard, Ebel, Samantha, Esquenazi-Karonika, Shari, Faustin, Arline, Febres, Elias, Fine, Jeffrey, Fink, Sandra, Freeland, Catherine, Frontera, Jennifer, Gallagher, Richard, Gonzalez-Duarte, Alejandra, Gross, Rachel, Hasson, Denise, Hill, Sophia, Hochman, Judith, Horwitz, Leora, Hossain, Jennifer, Islam, Shahidul, Jean, Christina Saint, Johnson, Stephen, Kansal, Neha, Katz, Stuart, Kenney, Rachel, Kershner, Tammy, Kewlani, Deepshikha, Kwak, Judy, Lamendola-Essel, Michelle F., Laury, Sarah, Laynor, Gregory, Lei, Lei, Leon, Terry, Linton, Janelle, Logan, Max, Malik, Nadia, Mamistvalova, Lia, Mandel, Hannah, Maranga, Gabrielle, Mattoo, Aprajita, Mei, Tony, Mendelsohn, Alan, Mercier, Emmanuelle, Vernetti, Patricio Millar, Miller, Marc, Mitchell, Maika, Moreira, Andre, Mudumbi, Praveen C., Nahin, Erica, Nair, Nandini, Nekulak, Joseph, Owens, Kellie, Parent, Brendan, Patibandla, Nandan, Petrov, Peter, Postelnicu, Radu, Pratt, Francesca, Randall, Isabelle, Rao, Priyatha, Rapkiewicz, Amy, Rizzo, JohnRoss, Rosas, Johana, Rose, Chelsea, Saint-Jean, Christina, Santacatterina, Michelle, Shah, Binita, Shaukat, Aasma, Simon, Naomi, Simsir, Aylin, Stinson, Miranda, Tang, Wenfei, Tatapudi, Vasishta, Thawani, Sujata, Thomas, Mary, Thorpe, Lorna, Tom, MeeLee, Treiha, Ethan, Troxel, Andrea, Truong, Jennifer, Udosen, Mmekom, Valencia, Carlos, Velazquez-Perez, Jessica, Vernetti, Patricio M., Vidal, Crystal, Viswanathan, Anand, Willerford, Amy, Williams, Natasha, Wong, Crystal, Wood, Marion J., Wuller, Shannon, Yin, Shonna H., Young, Chloe, Zaretsky, Jonah, Zavlunova, Susanna, Ahirwar, Shreya, Ahmed, Shifa, Ainsworth, Layne L., Atchley-Challenner, Rachel, Avilach, Paul, Balan, Trisha T., Benik, Nicholas, Benoit, Barbara, Bind, Marie-Abèle C., Bonaventura, William J., Boutin, Natalie, Brion, Beverly, Cagan, Andrew, Cai, Tianrun, Cao, Tingyi, Castro, Victor M., Cerretani, Xander R., Chan, James G., Cheng, David, Chibnik, Lori B., Ciriello, Mark, Costenbader, Karen, Dimitrov, Dimitar S., Estiri, Hossein, Fayad, Maria, Feldman, Candace H., Foulkes, Andrea, Gainer, Vivian, Ghosh, Bhaswati, Gollub, Randy, Guan, Zoe, Harris, Alan, Helmer, Karl, Hendrix, Andrew, Holzbach, Ana, Huang, Weixing, Karlson, Elizabeth W., Kaufman, Daniel, Keogh, Diane, Kerr, James D., Klann, Jeffrey G., Krishnamoorthy, Aparna, Lasky-Su, Jessica A., Liao, Katherine P., MacFadden, Doug, Maram, Anupama, Martel, Megan W., Mendis, Michael, Metta, Reeta, Monteiro, Jonathan, Morales, Eduardo, Morse, Richard E., Murphy, Shawn, Nazaire, Marc-Danie, Neils, Gregory, Nguyen, Amber N., Norman, James, Paik, Henry H., Pant, Deepti, Park, HeeKyong, Rabideau, Dustin J., Reeder, Harrison T., Rossi-Roh, Kathleen, Santacroce, Leah M., Schlepphorst, Katherine, Schulte, Carolin, Selvaggi, Caitlin A., Shinnick, Daniel J., Simons, William, Simpson, Lynn A., St. Jean Flanders, Mary L., Strasser, Zachary, Thakrar, Mansi R., Thaweethai, Tanayott, Thorn, Madeleine, Trewett, Philip, Van Fleet, Dustin, Wagholikar, Kavishwar B., Wang, Taowei D., Wattanasin, Nich, Weber, Griffin, Williams, Michael A., Zhang, Ren Zhe, Cicek, Mine, Chang, Nancy, Wirkus, Samantha, Zahnle, Nicole, Flotte, Thomas J., Frisch, Erika, Boysen, Erik M., Welch, Gary, Akintonwa, Teresa, Blancero, Frank, Brown, Heather-Elizabeth, Carmilani, Megan, Cerda, Marta, Clash, Victor H., Copeland, Debra, Hall, Yvonka, kevin kondo, Lerma, Lydia, Lindsay, Jacqui, Marti, Heather, Maughan, Christine, Minor, Tony, Taylor, Brittany, Vincent, Hyatt, Zissis, Mike, Anderson, Brett, Bardhan, Sujata, Castro-Baucom, Leah, Chisolm, Deena, Corchado, Claudia, Damian, April Joy, Daniel, Casey, DasGupta, Soham, Dehority, Walter, Feldman, Candace, Fessel, Josh, Rosas, Lisa Goldman, Horowitz, Carol, Khullar, Dhruv, Lopez, Keila, McDonald Pinkett, Shelly, Myaskovsky, Larissa, Regino, Lidia, St John Thomas, Gelise, Stewart de Ramirez, Sarah, Vangeepuram, Nita, Walden, Anita, Williams, Neely, Yin, Shonna, Burton, Phoebe, Catallozzi, Marina, Clark, Cheryl, Dworetzky, Beth, Edwards, Belinda, Ferrer, Robert L., Judd, Suzanne, Rothman, Russell, Wagner, Laura, Wallace, Ann, Adams, Sonseeahray (Ray), Aragon, Leyna, Bander, Bryan, Bishof, Karyn, Brooks, Gail, Carignan, Etienne, Coombs, Krista, Davis, Hannah, Blakley, Felicia D., Diggs, Marissa, Brown, Heather E., Favors, Umar, Fields, Whitney, Fisher, Liza, Fitzgerald, Megan, Gaffney, Alicia, Witvliet, Margot Gage, Garcia, Roberto, Gustafson, Tyler, Guthe, Nick, Holmes, Verna, Hornig, Mady, Hornig, Maxwell, Jefferson, Wendy, Kochis, Nancy, Kondo, Kevin, Lam, Julie, Lawrence, Fadwa, Letts, Rebecca, Lewis, Juan, Lopez, Silcia, Martinez, Thomas, McCorkell, Lisa, McGrath, Rebecca, Minor, Thomas T., Moore, Charita, Nguyen, Kian, Nichols, Lauren, O'Brien, Lisa, Olson, Holly, Peddie, Aimee, Perlowski, Alice, Lorenzo, Elizabeth P., Prentiss, Lisa, Raytselis, Nadia, Rochez, Nitza, Rockwell, Megan, Rutter, Jacqueline, Seibert, Elle, Sekar, Anisha, Smith, Chimere, Stiles, Lauren, Taylor, Emily, Thompson, Julie, Trapp, Stephen, Valdiva, Stephen, Wilensky, Rochelle, Williams, Melissa, Dawson, Kay W., Wylam, Andrew, Swank, Zoe, Borberg, Ella, Chen, Yulu, Senussi, Yasmeen, Chalise, Sujata, Manickas-Hill, Zachary, Yu, Xu G., Li, Jonathan Z., Alter, Galit, Kelly, J. Daniel, Goldberg, Sarah A., Talla, Aarthi, Li, Xiaojun, Skene, Peter, Bumol, Thomas F., Torgerson, Troy R., Czartoski, Julie L., McElrath, M. Juliana, and Walt, David R.
- Published
- 2024
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3. Familial dysautonomia
- Author
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González-Duarte, Alejandra, Cotrina-Vidal, Maria, Kaufmann, Horacio, and Norcliffe-Kaufmann, Lucy
- Published
- 2023
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4. Paradoxical manifestations during tuberculous meningitis treatment among HIV-negative patients: a retrospective descriptive study and literature review
- Author
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Domínguez-Moreno, Rogelio, García-Grimshaw, Miguel, Medina-Julio, David, Cantú-Brito, Carlos, and González-Duarte, Alejandra
- Published
- 2022
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5. Early autonomic biomarkers in ATTRv carriers
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González-Duarte, Alejandra and Norcliffe-Kauffman, Lucy
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- 2023
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6. Neurological manifestations temporally associated with SARS-CoV-2 infection in pediatric patients in Mexico
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Sánchez-Morales, Areli Estela, Urrutia-Osorio, Marta, Camacho-Mendoza, Esteban, Rosales-Pedraza, Gustavo, Dávila-Maldonado, Luis, González-Duarte, Alejandra, Herrera-Mora, Patricia, and Ruiz-García, Matilde
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- 2021
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7. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
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Vita, Giuseppe, Rizzo, Vincenzo, Russo, Massimo, Mazzeo, Anna, Gentile, Luca, Berk, John L, Brueckner, Caitlin, Lazzari, Victoria, Wiesman, Janice, DeLong, Douglas, Victory, Jennifer, Dalton, James, May, John, Gilmore, Catherine, Attarian, Shahram, Diallo, Saran, Delmont, Emilien, Pouget, Jean, Verschueren, Annie, Grapperon, Aude-Marie, Campana-Salort, Emmanuelle, Conceição, Isabel M, Lopes, Ana, Lamas, Filipa, Neves, Carlos, Castro, Jose, Pereira, Pedro, Castro, Isabel, Franco, Ana, Santos, Miguel Oliveira, de Azevedo Coutinho, Conceição, Falcao de Campos, Catarina, Coelho, Teresa, Hipólito Reis, Antonio, Correia, Nuno, Perez, Javier M, Martins da Silva, Ana, Alves, Cristina, Cardoso, Marcio, Valdrez, Katia, Monte, Julia R, Pessoa, Bernardete, Guimaraes, Nadia, Freitas, Monica, Ramalho, Joana, Ferreira, Natalia, Kuzume, Daisuke, Tard, Celine, Waucquier, Nawal, Rougeaux, Isabelle, Brice, Sylvie, Kasprzyk, Emmanuelle, Elrezzi, Elise, Meguig, Sayah, Hachulla, Eric, Gauvain, Clement, Migaud-Chervy, Maria-Claire, Deplanque, Dominique, Jozefowicz, Elsa, Lebellec, Loic, Adams, David, Balaya-Gouraya, Line, Jehan Lacour, Nathalie, Bournane, Halima, Martin, Nathalie, Elabed, Mongia, Sacko, Niamey, Boubrit, Yasmine, Gaouar, Amina, Rakotondratafika, Fetra, Théaudin-Saliou, Marie, Cauquil-Michon, Cécile, Labeyrie, Celine, Not, Adeline, Al-Salameh, Abdallah, Lecoq, Anne-Lise, Stephant, Maeva, Echaniz-Laguna, Andoni, Becquemont, Laurent, Beaudonnet, Guillemette, Algalarrondo, Vincent, Eliahou, Ludivine, Slama, Michel S, Rousseau, Antoine, Signate, Aissatou, Berthelot, Emeline, Inamo, Jocelyn, Planté-Bordeneuve, Violaine, Vervoitte, Laetitia, Focseneanu, Cecile, Gendre, Thierry, Arrouasse, Raphaele, Ayache, Samar S., Ernande, Laura, Le Corvoisier, Philippe, Salhi, Hayet, Choumert, Ariane, Ehinger, Vincent, Ruiz, Julie, Charlin, Cyril, Megelin, Thomas, Brannagan III, Thomas H, Fayerman, Raisy, Kim, Arreum, Paras, Allan, Gonzalez, Leidy J, Tsang, Steven, Wajnsztajn, Fernanda, Shije, Jeffrey, Ulane, Christina, Kleyman, Inna, Weimer, Louis, Cioroiu, Comana, Lambrianides, Sakis, Abu-Manneh, Rana, Zamba-Papanicolaou, Eleni, Agathangelou, Petros, Leonidou, Eleni, Tada, Satoshi, Fujita, Akemi, Nagai, Masahiro, Ando, Rina, Hosokawa, Yuko, Yamanishi, Yuki, Overcash, J. Scott, Giardino, Elena, Boyer, Leslie, Dang, Lien, Le, An, Nguyen, Tyler, Giang, Lien, Sellers, Peter, Tran, Leyla, Truong, Nghi, Vinas, Maita, Hrkman, Nicole, Miller, Sarah, Nguyen, David, Smith, Ashley, Pu, Helen, Li, Steve, Vuong, Thao, Dioso, Holly, Green, Sinikka, Lee, Kia, Chu, Hanh, Waters, Michael, Coskun, Derya J, Zepeda, Karla A, O'Riordan, William, Obici, Laura, Cortese, Andrea, Lozza, Alessandro, Merlini, Giampaolo, Rosti, Vittorio, Sabatelli, Mario, Bisogni, Giulia, Bernardo, Daniela, Luigetti, Marco, Di Paolantonio, Andrea, Guglielmino, Valeria, Romano, Angela, Nienhuis, Hans, Bulthuis-Kuiper, Janita, Kristen, Arnt V, Gerk, Olga, Ulbricht, Hannah, Taylor, Lenka, Meyle, Eva, Kleinschmidt, Natalia, Meyrath, David, Noe-Schwenn, Simone, Meng, Ulrike, Bauer, Ralf, aus dem Siepen, Fabian, Hein, Selina, Takahashi, Tetsuya, Oshita, Tomohiko, Koujin, Yoko, Neshige, Shuichiro, Nezu, Tomohisa, Segawa, Akiko, Ueno, Hiroki, Morino, Hiroyuki, Campistol, Josep M, Rodas Marin, Lida Maria, Blasco Pelicano, Josep Miquel, Dávila, Lucía Galán, Palacios, Marta, Pytel Cordoba, Vanesa, Guerrero Sola, Antonio, Horga, Alejandro, García Feijoo, Julián, Perez de Isla, Leopoldo, Marques Júnior, Wilson, Moscardini, Mariana, Litcanov, Debora Cristina, Viera Lima, Ana Flavia, Rodrigues, Leonardo, Marques Coutinho, Barbara, Moreira, Carolina Lavigne, Daccach Marques, Vanessa, Munoz Beamud, Francisco, Gragera Martínez, Álvaro, Borrachero, Cristina, Losada López, Inés Asunción, Cisneros Barroso, Eugenia, Rodríguez Rodríguez, Adrián, Sanz, Monica, Rigo Oliver, Elena, González Moreno, Juan, Gamez Martinez, Jose M, Descals, Cristina, Uson, Mercedes, Jose Vega, Francisco, Figuerola, Antoni, Montala, Carles, Waddington-Cruz, Márcia, Dias da Silva, Moises, Gervais de Santa Rosa, Renata, Pinto, Luiz Felipe, Pinto, Marcus Vinicius, Cardoso Berensztejn, Amanda, Barroso, Fabio, Lautre, Andrea, Orellana, Lucas G, González-Duarte Briseño, Maria Alejandra, Cárdenas-Soto, Karla, Jiménez López, Brenda Poled, Pérez-Castañeda, Sandra Lorena, Cantú Brito, Carlos Gerardo, Rivera de la Parra, David, Hernandez Reyes, Jose Pablo, del Mar Saniger Alba, Maria, Criollo Mora, Elia, Parman, Yesim, Rezzan, Kus Jülide, Sahin, Erdi, Serbest, Nail G, Durmus, Hacer, Cakar, Arman, Tugal Tutkun, Nuriye Ilknur, Karamursel, Sacit, Elitok, Ali, Sirin Inan, Nermin G, Altinkurt, Emre, Polydefkis, Michael, Ye, Jing, Allen, Adriane C, Chaudhry, Vinay, Jarrett, Raquel, Bressler, Neil, Burks, Kathleen L, Liu, Qingfeng, Khoshnoodi, Mohammad, Judge, Daniel P, Vista, Geno, Shah, Syed Mahmood, Hamaguchi, Hirotoshi, Oda, Junko, Fukase, Emi, Taniguchi, Ikuko, Oda, Tetsuya, Endo, Hironobu, Shimomura, Masahiro, Katanazaka, Kimitaka, Koto, Shusuke, Nakano, Takahiro, Scheid, Christof, Zueiter, Andreas, Pester, Lars, Walter, Doreen, Özdemir, Betül, Frenzel, Lukas F, Holtick, Udo, Oh, Jeeyoung, Kim, Hee Jin, Shin, Hyun Jin, Choi, Kyomin, Yamashita, Taro, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Ueda, Akihiko, Nakahara, Keiichi, Yorita, Akiko, Tsuruhisa, Seiko, Taniwaki, Takayuki, Harada, Masaya, Moritaka, Taiga, Sakurada, Naonori, Mauricio, Elizabeth A, Baskin, Amber, Dimberg, Elliot, Dispenzieri, Angela, Fonder, Amie, Hobbs, Miriam, Russell, Stephen J, Dyck, Peter, Gonsalves, Wilson, Leung, Nelson, Witzig, Thomas E, Zeldenrust, Steven R, Hwa, Lisa, Kapoor, Prashant, Kumar, Shaji K, Lin, Yi, Lust, John A, Rajkumar, Vincent S, Dingli, David, Gertz, Morie A, Go, Ronald, Hayman, Suzanne R, Dalia, Samir, Carrillo, Esmeralda, Gorevic, Peter, Mason, Garnette, Chao, Chi-Chao, Lee, Ming-Jen, Su, Jen-Jen, Hsieh, Sung-Tsang, Tsai, Li-Kai, Yeh, Shin-Joe, Yang, Chih-Chao, Ajroud-Driss, Senda Ajroud-Driss, Casey, Patricia, Joslin, Benjamin C, Freimer, Miriam, Sankey, Alison, Kenepp, Amanda, Heintzman, Sarah, LoRusso, Samantha, Hokezu, Youichi, Kim, Byoung-Joon, Kim, JuHyeon, Lee, Ga Yeon, Cho, Eun Bin, Jeon, Eun-Seok, Min, Ju-Hong, Seok, Jin Myoung, Lee, Hye Lim, Park, Jae Hong, Sekijima, Yoshiki, Miyazawa, Chinatsu, Kato, Nagaaki, Kishida, Dai, Hineno, Akiyo, Kodaira, Minori, Yoshinaga, Tsuneaki, Miyahara, Teruyoshi, Imai, Akira, Matsumoto, Kazuhiko, Lin, Kon-Ping, Lee, Yi-Chung, Wixner, Jonas, Falk, Malin, Pilebro, Bjorn, Suhr, Ole, Lindqvist, Per, Soderberg, Karin, Pedrosa-Domellöf, Fatima, Anan, Intissar, Nordh, Erik, Tournev, Ivaylo, Zhelyazkova-Glaveeva, Sashka, Cherneva, Zheyna, Sarafov, Staiko, Chamova, Teodora, Cherninkova-Gopina, Sylvia, Schmidt, Hartmut H, Friebel, Frauke, Zibert, Andree, Mihailovic, Natasa, Schubert, Friederike, Vorona, Elena, Lahme, Larissa, Huesing-Kabar, Anna, Schilling, Matthias, Kabar, Iyad, Gillmore, Julian D, Martinez-Naharro, Ana, Chacko, Liza, Cohen, Oliver, Law, Steven, Rezk, Tamer, Lachmann, Helen J, Quan, Dianna, Blume, Brianna, Dixon, Stacy, Low, Soon Chai, Chan, Soo Looi, Lim, He Eng Li, Goh, Khean Jin, Mezei, Michelle M, Kraus, Deborah, Jack, Kristin, Wade, N. Kevin, Lopate, Glenn, Zwijack, Brittany, Florence, Julaine, Sommerville, R. Brian, Stewart, Graeme, Ryder, Julie, Mekhael, Linda, Taylor, Mark, Suan, Daniel, Wells, Karen, Stone, Paula, Itoya, Amenze, Owusu-Sekyere, Mercy, Thai, Desmond, Chahine, Ilonah, Pedrosa, Salve, Do, Thi Hoa (Therese), González-Duarte, Alejandra, Kyriakides, Theodoros, Ajroud-Driss, Senda, Mauricio, Elizabeth, Brannagan, Thomas H, III, Aldinc, Emre, Wang, Jing Jing, White, Matthew T, Vest, John, Berber, Erhan, and Sweetser, Marianne T
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- 2021
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8. Cutaneous biomarkers of therapeutic efficacy in early treatment of hereditary ATTR amyloid polyneuropathy with tafamidis.
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Cárdenas‐Soto, Karla, Dominguez, Xel‐Ha, Cortes, Giovanni, Tsai, Felix, Saniger, Maria del Mar, Guraieb‐Chahin, Paola, Torres‐Ocatvo, Benjamín, Gibbons, Christopher, Kelly, Jeffery W., Freeman, Roy, and González‐Duarte, Alejandra
- Subjects
AMYLOID genetics ,PERIPHERAL neuropathy ,THYROXINE ,LEG ,RESEARCH funding ,NEURONS ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,SKIN ,AMYLOID ,POLYNEUROPATHIES ,DRUG efficacy ,THIGH ,COMPARATIVE studies ,BIOMARKERS - Abstract
Background: ATTR (ATTRv) amyloidosis neuropathy is characterized by progressive sensorimotor and autonomic nerve degeneration secondary to amyloid deposition caused by a misfolded transthyretin protein (TTR). Small nerve fiber neuropathy is an early clinical manifestation of this disease resulting from the dysfunction of the Aδ and C small nerve fibers. Tafamidis, a selective TTR stabilizer, has proven its efficacy in the earlier stages of hATTR. Objectives: To evaluate the clinical course and utility of cutaneous pathological biomarkers in patients with ATTR amyloidosis treated with tafamidis compared to control patients. Methods: Forty patients diagnosed with early stages of ATTRv amyloidosis (polyneuropathy disability [PND] scores 0‐II) underwent small and large nerve fiber neurological evaluations, and annual skin biopsies for intraepidermal nerve fiber density (IENFD) and amyloid deposition index (ADI) estimation. Thirty patients were allocated to receive tafamidis, and 10 patients served as controls. Tafamidis pharmacokinetics analysis was performed in patients who received the treatment. Results: At baseline, 12% of patients in stage PND 0 and 28% in PND I displayed small nerve fiber denervation in the distal thigh, whereas 23% and 38%, respectively, in the distal leg. Similarly, 72% and 84% had amyloid deposition in the distal thigh and 56% and 69% in the distal leg. Following 1 year of treatment, the tafamidis group showed significant clinical improvement compared to the control group, revealed by the following mean differences (1) −9.3 versus −4 points (p = <.00) in the patient's neuropathy total symptom score 6 (NTSS‐6) questionnaire, (2) −2.5 versus +2.8 points (p = <.00) in the Utah Early Neuropathy Score (UENS), and (3) +1.2°C versus −0.6 (p =.01) in cold detection thresholds. Among the patients who received tafamidis, 65% had stable or increased IENFD in their distal thigh and 27% in the distal leg. In contrast, all patients in the control group underwent denervation. The ADI either decreased or remained constant in 31% of the biopsies in the distal thigh and in 24% of the biopsies in the distal leg of the tafamidis‐treated patients, whereas it rose across all the biopsies in the control group. At the 4‐year follow‐up, the tafamidis group continued to display less denervation in the distal thigh (mean difference [MD] of −3.0 vs. −9.3 fibers/mm) and the distal leg (mean difference [MD] −4.9 vs. −8.6 fibers/mm). ADI in tafamidis‐treated patients was also lower in the distal thigh (10 vs. 30 amyloid/mm2) and the distal leg (23 vs. 40 amyloid/mm2) compared to control patients. Plasma tafamidis concentrations were higher in patients with IENFD improvement and in patients with reduced amyloid deposition. Patients without amyloid deposition in the distal leg at baseline displayed delayed disease progression at 4 years. Conclusions: Cutaneous IENFD and amyloid deposition assessments in the skin of the distal thigh and distal leg are valuable biomarkers for early diagnosis of ATTR amyloidosis and for measuring the progression of small nerve fiber neuropathy. Early treatment with tafamidis slows the clinical progression of the disease, skin denervation, and amyloid deposition in the skin. Higher plasma concentrations of tafamidis are associated with better disease outcomes, suggesting that increasing the drug dose could achieve better plasma concentrations and response rates. This study describes the longest small nerve fiber neuropathy therapeutic trial with tafamidis and is the first to report small fiber symptoms, function, and structural assessments as outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy
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González‐Duarte, Alejandra, Conceição, Isabel, Amass, Leslie, Botteman, Marc F., Carter, John A., and Stewart, Michelle
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- 2020
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10. Clinical, Imaging, and Laboratory Characteristics of Adult Mexican Patients with Tuberculous Meningitis: A Retrospective Cohort Study
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García-Grimshaw, Miguel, Gutiérrez-Manjarrez, Francisco Alejandro, Navarro-Álvarez, Samuel, and González-Duarte, Alejandra
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- 2020
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11. Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis
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González-Duarte, Alejandra, Berk, John L., Quan, Dianna, Mauermann, Michelle L., Schmidt, Hartmut H., Polydefkis, Michael, Waddington-Cruz, Márcia, Ueda, Mitsuharu, Conceição, Isabel M., Kristen, Arnt V., Coelho, Teresa, Cauquil, Cécile A., Tard, Céline, Merkel, Madeline, Aldinc, Emre, Chen, Jihong, Sweetser, Marianne T., Wang, Jing Jing, and Adams, David
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- 2020
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12. Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies
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González-Duarte, Alejandra, Varma-Doyle, Aditi, and Freeman, Roy
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- 2021
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13. Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis
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Maurer, Mathew S., primary, Kale, Parag, additional, Fontana, Marianna, additional, Berk, John L., additional, Grogan, Martha, additional, Gustafsson, Finn, additional, Hung, Rebecca R., additional, Gottlieb, Robert L., additional, Damy, Thibaud, additional, González-Duarte, Alejandra, additional, Sarswat, Nitasha, additional, Sekijima, Yoshiki, additional, Tahara, Nobuhiro, additional, Taylor, Mark S., additional, Kubanek, Milos, additional, Donal, Erwan, additional, Palecek, Tomas, additional, Tsujita, Kenichi, additional, Tang, W.H. Wilson, additional, Yu, Wen-Chung, additional, Obici, Laura, additional, Simões, Marcus, additional, Fernandes, Fábio, additional, Poulsen, Steen Hvitfeldt, additional, Diemberger, Igor, additional, Perfetto, Federico, additional, Solomon, Scott D., additional, Di Carli, Marcelo, additional, Badri, Prajakta, additional, White, Matthew T., additional, Chen, Jihong, additional, Yureneva, Elena, additional, Sweetser, Marianne T., additional, Jay, Patrick Y., additional, Garg, Pushkal P., additional, Vest, John, additional, and Gillmore, Julian D., additional
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- 2023
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14. Novel Treatments for Hereditary ATTRv Amyloidosis
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González-Duarte, Alejandra, primary
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- 2023
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15. Is 'happy hypoxia' in COVID-19 a disorder of autonomic interoception? A hypothesis
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González-Duarte, Alejandra and Norcliffe-Kaufmann, Lucy
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- 2020
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16. A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol
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Fragoso-Saavedra, Sergio, Iruegas-Nunez, David A., Quintero-Villegas, Alejandro, García-González, H. Benjamín, Nuñez, Isaac, Carbajal-Morelos, Sergio L., Audelo-Cruz, Belem M., Arias-Martínez, Sarahi, Caro-Vega, Yanink, Calva, Juan José, Luqueño-Martínez, Verónica, González-Duarte, Alejandra, Crabtree-Ramírez, Brenda, Crispín, José C., Sierra-Madero, Juan, Belaunzarán-Zamudio, Pablo F., and Valdés-Ferrer, Sergio I.
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- 2020
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17. Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay.
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Coelho, Teresa, Dispenzieri, Angela, Grogan, Martha, Conceição, Isabel, Waddington-Cruz, Márcia, Kristen, Arnt V., Wixner, Jonas, Diemberger, Igor, Gonzalez-Moreno, Juan, Maurer, Mathew S., Planté-Bordeneuve, Violaine, Garcia-Pavia, Pablo, Tournev, Ivailo, Gonzalez-Costello, Jose, Cariou, Eve, González-Duarte, Alejandra, Glass, Oliver, Chapman, Doug, and Amass, Leslie
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DELAYED diagnosis ,TRANSTHYRETIN ,AMYLOIDOSIS - Published
- 2023
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18. Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry
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Ntaios, George, Michel, Patrik, Georgiopoulos, Georgios, Guo, Yutao, Li, Wencheng, Xiong, Jing, Calleja, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Fuentes, Blanca, Alonso de Leciñana, María, Díez-Tejedor, Exuperio, García-Madrona, Sebastian, Masjuan, Jaime, DeFelipe, Alicia, Turc, Guillaume, Gonçalves, Bruno, Domigo, Valerie, Dan, Gheorghe-Andrei, Vezeteu, Roxana, Christensen, Hanne, Christensen, Louisa Marguerite, Meden, Per, Hajdarevic, Lejla, Rodriguez-Lopez, Angela, Díaz-Otero, Fernando, García-Pastor, Andrés, Gil-Nuñez, Antonio, Maslias, Errikos, Strambo, Davide, Werring, David J., Chandratheva, Arvind, Benjamin, Laura, Simister, Robert, Perry, Richard, Beyrouti, Rahma, Jabbour, Pascal, Sweid, Ahmad, Tjoumakaris, Stavropoula, Cuadrado-Godia, Elisa, Campello, Ana Rodríguez, Roquer, Jaume, Moreira, Tiago, Mazya, Michael V., Bandini, Fabio, Matz, Karl, Iversen, Helle K., González-Duarte, Alejandra, Tiu, Cristina, Ferrari, Julia, Vosko, Milan R., Salzer, Helmut J.F., Lamprecht, Bernd, Dünser, Martin W., Cereda, Carlo W., Quintero, Ángel Basilio Corredor, Korompoki, Eleni, Soriano-Navarro, Eduardo, Soto-Ramírez, Luis Enrique, Castañeda-Méndez, Paulo F., Bay-Sansores, Daniela, Arauz, Antonio, Cano-Nigenda, Vanessa, Kristoffersen, Espen Saxhaug, Tiainen, Marjaana, Strbian, Daniel, Putaala, Jukka, and Lip, Gregory Y.H.
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- 2020
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19. Correction to: Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis
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González-Duarte, Alejandra, Berk, John L., Quan, Dianna, Mauermann, Michelle L., Schmidt, Hartmut H., Polydefkis, Michael, Waddington-Cruz, Márcia, Ueda, Mitsuharu, Conceição, Isabel M., Kristen, Arnt V., Coelho, Teresa, Cauquil, Cécile A., Tard, Céline, Merkel, Madeline, Aldinc, Emre, Chen, Jihong, Sweetser, Marianne T., Wang, Jing Jing, and Adams, David
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- 2020
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20. Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis: Analysis of the APOLLO Study
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Solomon, Scott D., Adams, David, Kristen, Arnt, Grogan, Martha, González-Duarte, Alejandra, Maurer, Mathew S., Merlini, Giampaolo, Damy, Thibaud, Slama, Michel S., Brannagan, Thomas H., III, Dispenzieri, Angela, Berk, John L., Shah, Amil M., Garg, Pushkal, Vaishnaw, Akshay, Karsten, Verena, Chen, Jihong, Gollob, Jared, Vest, John, and Suhr, Ole
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- 2019
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21. What a neurologist must know of hereditary ATTRv amyloidosis
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Briseño-Godínez, Maria E., primary, Cárdenas-Soto, Karla, additional, Domínguez-Vega, Rosa X., additional, and González-Duarte, Alejandra, additional
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- 2023
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22. 137 PRIMARY RESULTS FROM APOLLO-B, A PHASE 3 STUDY OF PATISIRAN IN PATIENTS WITH TRANSTHYRETIN-MEDIATED AMYLOIDOSIS WITH CARDIOMYOPATHY
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Longhi(on Behalf Of), Simone, primary, Maurer, Mathew S, additional, Fontana, Marianna, additional, Berk, John L, additional, Gustafsson, Finn, additional, Simões, Marcos, additional, Grogan, Martha, additional, Fernandes, Fábio, additional, Gottlieb, Robert L, additional, Kubanek, Milos, additional, Poulsen, Steen, additional, Damy, Thibaud, additional, Diemberger, Igor, additional, Tahara, Nobuhiro, additional, Yu, Wen-chuhg, additional, Wilson Tang, W H, additional, Obici, Laura, additional, González-duarte, Alejandra, additional, Sekijima, Yoshiki, additional, White, Matthew T, additional, Yureneva, Elena, additional, Jay, Patrick Y, additional, Vest, John, additional, and Gillmore, Julian D, additional
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- 2022
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23. Detection of sudomotor alterations evaluated by Sudoscan in patients with recently diagnosed type 2 diabetes
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García-Ulloa, Ana Cristina, primary, Almeda-Valdes, Paloma, additional, Cuatecontzi-Xochitiotzi, Teresa Enedina, additional, Ramírez-García, Jorge Alberto, additional, Díaz-Pineda, Michelle, additional, Garnica-Carrillo, Fernanda, additional, González-Duarte, Alejandra, additional, Narayan, K M Venkat, additional, Aguilar-Salinas, Carlos Alberto, additional, and Hernández-Jiménez, Sergio, additional
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- 2022
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24. Amyloidosis due to TTR mutations in Mexico with 4 distincts genotypes in the index cases
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González-Duarte, Alejandra, Cárdenas-Soto, Karla, Bañuelos, Carlo Enrico, Fueyo, Omar, Dominguez, Carolina, Torres, Benjamín, and Cantú-Brito, Carlos
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- 2018
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25. Characteristics of patients with autonomic dysfunction in the Transthyretin Amyloidosis Outcomes Survey (THAOS)
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Barroso, Fabio A., Coelho, Teresa, Dispenzieri, Angela, Conceição, Isabel, Waddington-Cruz, Marcia, Wixner, Jonas, Maurer, Mathew S., Rapezzi, Claudio, Planté-Bordeneuve, Violaine, Kristen, Arnt V., González-Duarte, Alejandra, Chapman, Doug, Stewart, Michelle, Amass, Leslie, Barroso, Fabio A., Coelho, Teresa, Dispenzieri, Angela, Conceição, Isabel, Waddington-Cruz, Marcia, Wixner, Jonas, Maurer, Mathew S., Rapezzi, Claudio, Planté-Bordeneuve, Violaine, Kristen, Arnt V., González-Duarte, Alejandra, Chapman, Doug, Stewart, Michelle, and Amass, Leslie
- Abstract
Background: Autonomic dysfunction is common in transthyretin amyloidosis (ATTR amyloidosis), but its frequency, characteristics, and quality-of-life (QoL) impact are not well understood. Methods: The Transthyretin Amyloidosis Outcomes Survey (THAOS) is an ongoing, global, longitudinal survey of patients with ATTR amyloidosis, including patients with inherited (ATTRv) and wild-type (ATTRwt) disease and asymptomatic patients with TTR mutations (ClinicalTrials.gov: NCT00628745). In a descriptive analysis, characteristics and Norfolk QoL-DN total (TQoL) scores at enrolment were compared in patients with vs without autonomic dysfunction (analysis cut-off: 1 August 2020). Results: Autonomic dysfunction occurred in 1181/2922 (40.4%) symptomatic patients, and more commonly in ATTRv (1107/1181 [93.7%]) than ATTRwt (74/1181 [6.3%]) amyloidosis. Time (mean [SD]) from ATTR amyloidosis symptom onset to first autonomic dysfunction symptom was shorter in ATTRv (3.4 [5.7] years) than ATTRwt disease (9.7 [10.4]). In ATTRv disease, patients with vs without autonomic dysfunction had worse QoL (TQoL, 47.3 [33.2] vs 16.1 [18.1]); in ATTRwt disease, those with vs without autonomic dysfunction had similar QoL (23.0 [18.2] vs 19.9 [20.5]). Conclusions: Autonomic dysfunction was more common and presented earlier in symptomatic ATTRv than ATTRwt amyloidosis and adversely affected QoL in ATTRv disease. These THAOS findings may aid clinicians in diagnosing and treating patients with ATTR amyloidosis. Trial registration: ClinicalTrials.gov: NCT00628745.
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- 2022
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26. Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial.
- Author
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Adams, David, Tournev, Ivailo L., Taylor, Mark S., Coelho, Teresa, Planté-Bordeneuve, Violaine, Berk, John L., González-Duarte, Alejandra, Gillmore, Julian D., Low, Soon-Chai, Sekijima, Yoshiki, Obici, Laura, Chen, Chongshu, Badri, Prajakta, Arum, Seth M., Vest, John, and Polydefkis, Michael
- Subjects
CLINICAL trials ,AMYLOIDOSIS ,PATIENT safety ,POLYNEUROPATHIES - Abstract
The study objective was to assess the effect of vutrisiran, an RNA interference therapeutic that reduces transthyretin (TTR) production, in patients with hereditary transthyretin (ATTRv) amyloidosis with polyneuropathy. HELIOS-A was a phase 3, global, open-label study comparing the efficacy and safety of vutrisiran with an external placebo group (APOLLO study). Patients were randomized 3:1 to subcutaneous vutrisiran 25 mg every 3 months (Q3M) or intravenous patisiran 0.3 mg/kg every 3 weeks (Q3W) for 18 months. HELIOS-A enrolled 164 patients (vutrisiran, n = 122; patisiran reference group, n = 42); external placebo, n = 77. Vutrisiran met the primary endpoint of change from baseline in modified Neuropathy Impairment Score +7 (mNIS+7) at 9 months (p = 3.54 × 10
−12 ), and all secondary efficacy endpoints; significant improvements versus external placebo were observed in Norfolk Quality of Life-Diabetic Neuropathy, 10-meter walk test (both at 9 and 18 months), mNIS+7, modified body-mass index, and Rasch-built Overall Disability Scale (all at 18 months). TTR reduction with vutrisiran Q3M was non-inferior to within-study patisiran Q3W. Most adverse events were mild or moderate in severity, and consistent with ATTRv amyloidosis natural history. There were no drug-related discontinuations or deaths. Vutrisiran significantly improved multiple disease-relevant outcomes for ATTRv amyloidosis versus external placebo, with an acceptable safety profile. NCT03759379 [ABSTRACT FROM AUTHOR]- Published
- 2023
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27. HELIOS-A: Results from the Phase 3 Study of Vutrisiran in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy (S8.003)
- Author
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Adams, David, primary, Tournev, Ivailo, additional, Taylor, Mark, additional, Coelho, Teresa, additional, Planté-Bordeneuve, Violaine, additional, Berk, John, additional, González-Duarte, Alejandra, additional, Gillmore, Julian, additional, Low, Soon-Chai, additional, Sekijima, Yoshiki, additional, Obici, Laura, additional, Chen, Chongshu, additional, Badri, Prajakta, additional, Arum, Seth, additional, Vest, John, additional, and Polydefkis, Michael, additional
- Published
- 2022
- Full Text
- View/download PDF
28. Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial
- Author
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Adams, David, Tournev, Ivailo L., Taylor, Mark S., Coelho, Teresa, Planté-Bordeneuve, Violaine, Berk, John L., González-Duarte, Alejandra, Gillmore, Julian D., Low, Soon-Chai, Sekijima, Yoshiki, Obici, Laura, Chen, Chongshu, Badri, Prajakta, Arum, Seth M., Vest, John, and Polydefkis, Michael
- Abstract
The study objective was to assess the effect of vutrisiran, an RNA interference therapeutic that reduces transthyretin (TTR) production, in patients with hereditary transthyretin (ATTRv) amyloidosis with polyneuropathy. HELIOS-A was a phase 3, global, open-label study comparing the efficacy and safety of vutrisiran with an external placebo group (APOLLO study). Patients were randomized 3:1 to subcutaneous vutrisiran 25 mg every 3 months (Q3M) or intravenous patisiran 0.3 mg/kg every 3 weeks (Q3W) for 18 months. HELIOS-A enrolled 164 patients (vutrisiran, n = 122; patisiran reference group, n = 42); external placebo, n = 77. Vutrisiran met the primary endpoint of change from baseline in modified Neuropathy Impairment Score +7 (mNIS+7) at 9 months (p = 3.54 × 10−12), and all secondary efficacy endpoints; significant improvements versus external placebo were observed in Norfolk Quality of Life-Diabetic Neuropathy, 10-meter walk test (both at 9 and 18 months), mNIS+7, modified body-mass index, and Rasch-built Overall Disability Scale (all at 18 months). TTR reduction with vutrisiran Q3M was non-inferior to within-study patisiran Q3W. Most adverse events were mild or moderate in severity, and consistent with ATTRv amyloidosis natural history. There were no drug-related discontinuations or deaths. Vutrisiran significantly improved multiple disease-relevant outcomes for ATTRv amyloidosis versus external placebo, with an acceptable safety profile. NCT03759379
- Published
- 2022
- Full Text
- View/download PDF
29. Vitreous involvement as initial presentation of hereditary transthyretin amyloidosis related to the rare TTR Ile107Met (p.Ile127Met) pathogenic variant
- Author
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Treviño-Herrera, Alan Baltazar, primary, Bustamante-Vargas, Ana Patricia, additional, Lisker-Cervantes, Andrés, additional, Ríos Y Valles Valles, Dolores, additional, Villanueva-Mendoza, Cristina, additional, González-Duarte, Alejandra, additional, and Concha-Del-Río, Luz Elena, additional
- Published
- 2022
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30. “Red-flag” symptom clusters in transthyretin familial amyloid polyneuropathy
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Conceição, Isabel, González-Duarte, Alejandra, Obici, Laura, Schmidt, Hartmut H.-J., Simoneau, Damien, Ong, Moh-Lim, and Amass, Leslie
- Published
- 2016
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31. Creutzel-Jakob disease mimics a Richardson syndrome, spectrum of supranuclear progressive palsy
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García, Daniel Rebolledo, Fernandez, Arturo Cadena, González-Duarte, Alejandra, Vega, Rosa Xel Ha Dominguez, Vargas, Perfecto Oscar Gonzalez, and Sanchez, Griselda Teresa Romero
- Published
- 2021
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32. HELIOS-A: 9-month results from the phase 3 study of vutrisiran in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy
- Author
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Adams, Davide, Tournev, Ivailo, Taylor, Mark, Coelho, Teresa, Planté-Bordeneuve, Violaine, Berk, John, González-Duarte, Alejandra, Gillmore, Julian, Low, Soon-Chai, Sekijima, Yoshiki, Obici, Laura, Blakesley, Rick, Arum, Seth, Shilling, Rebecca, Vest, John, and Polydefkis, Michael
- Published
- 2021
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33. Global open-label extension: 24-month data of patisiran in patients with HATTR amyloidosis
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Luigetti, Marco, Adams, Davide, González-Duarte, Alejandra, Mauricio, Elizabeth, Brannagan, Thomas, Coelho, Teresa, Wixner, Jonas, Schmidt, Hartmut, Berber, Erhan, Sweetser, Marianne T., White, Matthew T., Wang, Jing Jing, and Polydefkis, Michael
- Published
- 2021
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34. Characteristics and predictors for silent hypoxemia in a cohort of hospitalized COVID-19 patients
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García-Grimshaw, Miguel, primary, Flores-Silva, Fernando Daniel, additional, Chiquete, Erwin, additional, Cantú-Brito, Carlos, additional, Michel-Chávez, Anaclara, additional, Vigueras-Hernández, Alma Poema, additional, Domínguez-Moreno, Rogelio, additional, Chávez-Martínez, Oswaldo Alan, additional, Sánchez-Torres, Samantha, additional, Marché-Fernández, Osvaldo Alexis, additional, and González-Duarte, Alejandra, additional
- Published
- 2021
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35. Paradoxical manifestations during tuberculous meningitis treatment among HIV-negative patients: a retrospective descriptive study and literature review
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Domínguez-Moreno, Rogelio, primary, García-Grimshaw, Miguel, additional, Medina-Julio, David, additional, Cantú-Brito, Carlos, additional, and González-Duarte, Alejandra, additional
- Published
- 2021
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36. Brain and spinal cord abscesses caused by Mycobacterium mucogenicum in an immunocompetent patient
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Tristán-Samaniego, Dioselina Panamá, primary, García-Grimshaw, Miguel, additional, Jiménez-Ruiz, Amado, additional, and González-Duarte, Alejandra, additional
- Published
- 2021
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37. Transthyretin Amyloidosis Therapies: Guiding the Future
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González-Duarte, Alejandra, primary
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- 2021
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38. COVID-19-related diffuse posthypoxic leukoencephalopathy and microbleeds masquerades as acute necrotizing encephalopathy.
- Author
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Tristán-Samaniego, Dioselina Panamá, Chiquete, Erwin, Treviño-Frenk, Irene, Rubalcava-Ortega, Johnatan, Higuera-Calleja, Jesús Antonio, Romero-Sánchez, Griselda, Espinoza-Alvarado, Lissett, Barrera-Vargas, Ana, Flores-Silva, Fernando, González-Duarte, Alejandra, Vega-Boada, Felipe, and Cantú-Brito, Carlos
- Subjects
SARS-CoV-2 ,LEUKOENCEPHALOPATHIES ,COVID-19 ,CORONAVIRUS diseases ,BRAIN diseases ,CEREBRAL edema - Abstract
The complications of coronavirus disease 2019 (COVID-19), the clinical entity caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are not limited to the respiratory system. Leukoencephalopathy with microbleeds is increasingly seen in patients with COVID-19. New information is needed to delineate better the clinical implications of this infectious disease. A 46-year-old man with confirmed SARS-CoV-2 infection was admitted to the intensive care unit (ICU) with severe COVID-19. After transfer to the general wards, the patient was noted drowsy, disorientated, with slow thinking and speech. A brain MRI showed bilateral symmetrical hyperintense lesions in the deep and subcortical whiter matter, involving the splenium of the corpus callosum, as well as multiple microhemorrhages implicating the splenium and subcortical white matter. No contrast-enhanced lesions were observed in brain CT or MRI. CSF analysis showed no abnormalities, including a negative rtRT-PCR for SARS-CoV-2. An outpatient follow-up visit showed near-complete clinical recovery and resolution of the hyperintense lesions on MRI, without microbleeds change. We present the case of a survivor of severe COVID-19 who presented diffuse posthypoxic leukoencephalopathy, and microbleeds masquerading as acute necrotizing encephalopathy. We postulate that this kind of cerebral vasogenic edema with microbleeds could be the consequence of hypoxia, inflammation, the prothrombotic state and medical interventions such as mechanical ventilation and anticoagulation. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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39. Global & Community Health: Implementation of and Patient Satisfaction With the First Neurologic Telemedicine Program in Mexico During COVID-19
- Author
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Domínguez-Moreno, Rogelio, primary, García-Grimshaw, Miguel, additional, Chávez-Martínez, Oswaldo Alan, additional, Rebolledo-García, Daniel, additional, Diestel-Bautista, Jarumi Crystal, additional, Michel-Chávez, Anaclara, additional, Calderón-Martínez, Juan Andrés, additional, Tristán-Samaniego, Dioselina Panamá, additional, Vigueras-Hernández, Alma, additional, Estrada-Rodríguez, Humberto, additional, Vega-Boada, Felipe Arturo, additional, Dávila-Maldonado, Luis, additional, Tanimoto, Miguel Ángel, additional, Cantú-Brito, Carlos, additional, and González-Duarte, Alejandra, additional
- Published
- 2021
- Full Text
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40. Supplemental Data.pdf
- Author
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García-Grimshaw, Miguel, Domínguez-Moreno, Rogelio, Chávez-Martínez, Oswaldo Alan, Rebolledo-García, Daniel, Jarumi Crystal Diestel-Bautista, Michel-Chávez, Anaclara, Martínez, Juan Andrés Calderón, Dioselina Panamá Tristán-Samaniego, Vigueras-Hernández, Alma, Estrada-Rodríguez, Humberto, Vega-Boada, Felipe Arturo, Dávila-Maldonado, Luis, Tanimoto-Licona, Miguel Ángel, Cantú-Brito, Carlos, and González-Duarte, Alejandra
- Abstract
Implementation and Patient Satisfaction of the First Neurological Telemedicine Program in Mexico
- Published
- 2021
- Full Text
- View/download PDF
41. Multiple sclerosis typical clinical and MRI findings in a patient with HIV infection
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González-Duarte, Alejandra, Ramirez, Carlos, Pinales, Ricardo, and Sierra-Madero, Juan
- Published
- 2011
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42. Clinical Description of Intracranial Hemorrhage Associated with Bleeding Disorders
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González-Duarte, Alejandra, García-Ramos, Guillermo S., Valdés-Ferrer, Sergio Iván, and Cantú-Brito, Carlos
- Published
- 2008
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43. Acute Hydrocephalus and Stroke in a 20 Year-Old Man
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González-Duarte, Alejandra, Venzor-Castellanos, Juan Pablor, Treviño-Frenk, Irene, Cano-García, Fernando, and Barrios-Ordoñez, Ariadna
- Published
- 2014
- Full Text
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44. HELIOS-A: 9-month Results from the Phase 3 Study of Vutrisiran in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy (1234)
- Author
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Adams, David, primary, Tournev, Ivailo L., additional, Taylor, Mark S., additional, Coelho, Teresa, additional, Planté-Bordeneuve, Violaine, additional, Berk, John L., additional, González-Duarte, Alejandra, additional, Gillmore, Julian D., additional, Low, Soon-Chai, additional, Sekijima, Yoshiki, additional, Obici, Laura, additional, Blakesley, Rick, additional, Arum, Seth, additional, Shilling, Rebecca, additional, Vest, John, additional, and Polydefkis, Michael, additional
- Published
- 2021
- Full Text
- View/download PDF
45. Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City
- Author
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Flores-Silva, Fernando Daniel, primary, García-Grimshaw, Miguel, additional, Valdés-Ferrer, Sergio Iván, additional, Vigueras-Hernández, Alma Poema, additional, Domínguez-Moreno, Rogelio, additional, Tristán-Samaniego, Dioselina Panamá, additional, Michel-Chávez, Anaclara, additional, González-Duarte, Alejandra, additional, Vega-Boada, Felipe A., additional, Reyes-Melo, Isael, additional, Jiménez-Ruiz, Amado, additional, Chávez-Martínez, Oswaldo Alan, additional, Rebolledo-García, Daniel, additional, Marché-Fernández, Osvaldo Alexis, additional, Sánchez-Torres, Samantha, additional, García-Ramos, Guillermo, additional, Cantú-Brito, Carlos, additional, and Chiquete, Erwin, additional
- Published
- 2021
- Full Text
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46. Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke:The Global COVID-19 Stroke Registry
- Author
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Ntaios, George, Michel, Patrik, Georgiopoulos, Georgios, Guo, Yutao, Li, Wencheng, Xiong, Jing, Calleja, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Fuentes, Blanca, Alonso de Leciñana, María, Díez-Tejedor, Exuperio, García-Madrona, Sebastian, Masjuan, Jaime, DeFelipe, Alicia, Turc, Guillaume, Gonçalves, Bruno, Domigo, Valerie, Dan, Gheorghe-Andrei, Vezeteu, Roxana, Christensen, Hanne, Christensen, Louisa Marguerite, Meden, Per, Hajdarevic, Lejla, Rodriguez-Lopez, Angela, Díaz-Otero, Fernando, García-Pastor, Andrés, Gil-Nuñez, Antonio, Maslias, Errikos, Strambo, Davide, Werring, David J, Chandratheva, Arvind, Benjamin, Laura, Simister, Robert, Perry, Richard, Beyrouti, Rahma, Jabbour, Pascal, Sweid, Ahmad, Tjoumakaris, Stavropoula, Cuadrado-Godia, Elisa, Campello, Ana Rodríguez, Roquer, Jaume, Moreira, Tiago, Mazya, Michael V, Bandini, Fabio, Matz, Karl, Iversen, Helle K, González-Duarte, Alejandra, Tiu, Cristina, Ferrari, Julia, Vosko, Milan R, Salzer, Helmut J F, Lamprecht, Bernd, Dünser, Martin W, Cereda, Carlo W, Quintero, Ángel Basilio Corredor, Korompoki, Eleni, Soriano-Navarro, Eduardo, Soto-Ramírez, Luis Enrique, Castañeda-Méndez, Paulo F, Bay-Sansores, Daniela, Arauz, Antonio, Cano-Nigenda, Vanessa, Kristoffersen, Espen Saxhaug, Tiainen, Marjaana, Strbian, Daniel, Putaala, Jukka, Lip, Gregory Y H, Ntaios, George, Michel, Patrik, Georgiopoulos, Georgios, Guo, Yutao, Li, Wencheng, Xiong, Jing, Calleja, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Fuentes, Blanca, Alonso de Leciñana, María, Díez-Tejedor, Exuperio, García-Madrona, Sebastian, Masjuan, Jaime, DeFelipe, Alicia, Turc, Guillaume, Gonçalves, Bruno, Domigo, Valerie, Dan, Gheorghe-Andrei, Vezeteu, Roxana, Christensen, Hanne, Christensen, Louisa Marguerite, Meden, Per, Hajdarevic, Lejla, Rodriguez-Lopez, Angela, Díaz-Otero, Fernando, García-Pastor, Andrés, Gil-Nuñez, Antonio, Maslias, Errikos, Strambo, Davide, Werring, David J, Chandratheva, Arvind, Benjamin, Laura, Simister, Robert, Perry, Richard, Beyrouti, Rahma, Jabbour, Pascal, Sweid, Ahmad, Tjoumakaris, Stavropoula, Cuadrado-Godia, Elisa, Campello, Ana Rodríguez, Roquer, Jaume, Moreira, Tiago, Mazya, Michael V, Bandini, Fabio, Matz, Karl, Iversen, Helle K, González-Duarte, Alejandra, Tiu, Cristina, Ferrari, Julia, Vosko, Milan R, Salzer, Helmut J F, Lamprecht, Bernd, Dünser, Martin W, Cereda, Carlo W, Quintero, Ángel Basilio Corredor, Korompoki, Eleni, Soriano-Navarro, Eduardo, Soto-Ramírez, Luis Enrique, Castañeda-Méndez, Paulo F, Bay-Sansores, Daniela, Arauz, Antonio, Cano-Nigenda, Vanessa, Kristoffersen, Espen Saxhaug, Tiainen, Marjaana, Strbian, Daniel, Putaala, Jukka, and Lip, Gregory Y H
- Abstract
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (med
- Published
- 2020
47. Bioethics in Medical Care Rationing During the Coronavirus Disease-19 Pandemic
- Author
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González-Duarte, Alejandra, primary, Kaufer-Horwitz, Martha, additional, Gamba, Gerardo, additional, Rivera-Moscoso, Raúl, additional, and Aguilar-Salinas, Carlos A., additional
- Published
- 2021
- Full Text
- View/download PDF
48. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
- Author
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Adams, David, primary, Polydefkis, Michael, additional, González-Duarte, Alejandra, additional, Wixner, Jonas, additional, Kristen, Arnt V, additional, Schmidt, Hartmut H, additional, Berk, John L, additional, Losada López, Inés Asunción, additional, Dispenzieri, Angela, additional, Quan, Dianna, additional, Conceição, Isabel M, additional, Slama, Michel S, additional, Gillmore, Julian D, additional, Kyriakides, Theodoros, additional, Ajroud-Driss, Senda, additional, Waddington-Cruz, Márcia, additional, Mezei, Michelle M, additional, Planté-Bordeneuve, Violaine, additional, Attarian, Shahram, additional, Mauricio, Elizabeth, additional, Brannagan, Thomas H, additional, Ueda, Mitsuharu, additional, Aldinc, Emre, additional, Wang, Jing Jing, additional, White, Matthew T, additional, Vest, John, additional, Berber, Erhan, additional, Sweetser, Marianne T, additional, Coelho, Teresa, additional, Vita, Giuseppe, additional, Rizzo, Vincenzo, additional, Russo, Massimo, additional, Mazzeo, Anna, additional, Gentile, Luca, additional, Brueckner, Caitlin, additional, Lazzari, Victoria, additional, Wiesman, Janice, additional, DeLong, Douglas, additional, Victory, Jennifer, additional, Dalton, James, additional, May, John, additional, Gilmore, Catherine, additional, Diallo, Saran, additional, Delmont, Emilien, additional, Pouget, Jean, additional, Verschueren, Annie, additional, Grapperon, Aude-Marie, additional, Campana-Salort, Emmanuelle, additional, Lopes, Ana, additional, Lamas, Filipa, additional, Neves, Carlos, additional, Castro, Jose, additional, Pereira, Pedro, additional, Castro, Isabel, additional, Franco, Ana, additional, Santos, Miguel Oliveira, additional, de Azevedo Coutinho, Conceição, additional, Falcao de Campos, Catarina, additional, Hipólito Reis, Antonio, additional, Correia, Nuno, additional, Perez, Javier M, additional, Martins da Silva, Ana, additional, Alves, Cristina, additional, Cardoso, Marcio, additional, Valdrez, Katia, additional, Monte, Julia R, additional, Pessoa, Bernardete, additional, Guimaraes, Nadia, additional, Freitas, Monica, additional, Ramalho, Joana, additional, Ferreira, Natalia, additional, Kuzume, Daisuke, additional, Tard, Celine, additional, Waucquier, Nawal, additional, Rougeaux, Isabelle, additional, Brice, Sylvie, additional, Kasprzyk, Emmanuelle, additional, Elrezzi, Elise, additional, Meguig, Sayah, additional, Hachulla, Eric, additional, Gauvain, Clement, additional, Migaud-Chervy, Maria-Claire, additional, Deplanque, Dominique, additional, Jozefowicz, Elsa, additional, Lebellec, Loic, additional, Adams, David, additional, Balaya-Gouraya, Line, additional, Jehan Lacour, Nathalie, additional, Bournane, Halima, additional, Martin, Nathalie, additional, Elabed, Mongia, additional, Sacko, Niamey, additional, Boubrit, Yasmine, additional, Gaouar, Amina, additional, Rakotondratafika, Fetra, additional, Théaudin-Saliou, Marie, additional, Cauquil-Michon, Cécile, additional, Labeyrie, Celine, additional, Not, Adeline, additional, Al-Salameh, Abdallah, additional, Lecoq, Anne-Lise, additional, Stephant, Maeva, additional, Echaniz-Laguna, Andoni, additional, Becquemont, Laurent, additional, Beaudonnet, Guillemette, additional, Algalarrondo, Vincent, additional, Eliahou, Ludivine, additional, Rousseau, Antoine, additional, Signate, Aissatou, additional, Berthelot, Emeline, additional, Inamo, Jocelyn, additional, Vervoitte, Laetitia, additional, Focseneanu, Cecile, additional, Gendre, Thierry, additional, Arrouasse, Raphaele, additional, Ayache, Samar S., additional, Ernande, Laura, additional, Le Corvoisier, Philippe, additional, Salhi, Hayet, additional, Choumert, Ariane, additional, Ehinger, Vincent, additional, Ruiz, Julie, additional, Charlin, Cyril, additional, Megelin, Thomas, additional, Brannagan III, Thomas H, additional, Fayerman, Raisy, additional, Kim, Arreum, additional, Paras, Allan, additional, Gonzalez, Leidy J, additional, Tsang, Steven, additional, Wajnsztajn, Fernanda, additional, Shije, Jeffrey, additional, Ulane, Christina, additional, Kleyman, Inna, additional, Weimer, Louis, additional, Cioroiu, Comana, additional, Lambrianides, Sakis, additional, Abu-Manneh, Rana, additional, Zamba-Papanicolaou, Eleni, additional, Agathangelou, Petros, additional, Leonidou, Eleni, additional, Tada, Satoshi, additional, Fujita, Akemi, additional, Nagai, Masahiro, additional, Ando, Rina, additional, Hosokawa, Yuko, additional, Yamanishi, Yuki, additional, Overcash, J. Scott, additional, Giardino, Elena, additional, Boyer, Leslie, additional, Dang, Lien, additional, Le, An, additional, Nguyen, Tyler, additional, Giang, Lien, additional, Sellers, Peter, additional, Tran, Leyla, additional, Truong, Nghi, additional, Vinas, Maita, additional, Hrkman, Nicole, additional, Miller, Sarah, additional, Nguyen, David, additional, Smith, Ashley, additional, Pu, Helen, additional, Li, Steve, additional, Vuong, Thao, additional, Dioso, Holly, additional, Green, Sinikka, additional, Lee, Kia, additional, Chu, Hanh, additional, Waters, Michael, additional, Coskun, Derya J, additional, Zepeda, Karla A, additional, O'Riordan, William, additional, Obici, Laura, additional, Cortese, Andrea, additional, Lozza, Alessandro, additional, Merlini, Giampaolo, additional, Rosti, Vittorio, additional, Sabatelli, Mario, additional, Bisogni, Giulia, additional, Bernardo, Daniela, additional, Luigetti, Marco, additional, Di Paolantonio, Andrea, additional, Guglielmino, Valeria, additional, Romano, Angela, additional, Nienhuis, Hans, additional, Bulthuis-Kuiper, Janita, additional, Gerk, Olga, additional, Ulbricht, Hannah, additional, Taylor, Lenka, additional, Meyle, Eva, additional, Kleinschmidt, Natalia, additional, Meyrath, David, additional, Noe-Schwenn, Simone, additional, Meng, Ulrike, additional, Bauer, Ralf, additional, aus dem Siepen, Fabian, additional, Hein, Selina, additional, Takahashi, Tetsuya, additional, Oshita, Tomohiko, additional, Koujin, Yoko, additional, Neshige, Shuichiro, additional, Nezu, Tomohisa, additional, Segawa, Akiko, additional, Ueno, Hiroki, additional, Morino, Hiroyuki, additional, Campistol, Josep M, additional, Rodas Marin, Lida Maria, additional, Blasco Pelicano, Josep Miquel, additional, Dávila, Lucía Galán, additional, Palacios, Marta, additional, Pytel Cordoba, Vanesa, additional, Guerrero Sola, Antonio, additional, Horga, Alejandro, additional, García Feijoo, Julián, additional, Perez de Isla, Leopoldo, additional, Marques Júnior, Wilson, additional, Moscardini, Mariana, additional, Litcanov, Debora Cristina, additional, Viera Lima, Ana Flavia, additional, Rodrigues, Leonardo, additional, Marques Coutinho, Barbara, additional, Moreira, Carolina Lavigne, additional, Daccach Marques, Vanessa, additional, Munoz Beamud, Francisco, additional, Gragera Martínez, Álvaro, additional, Borrachero, Cristina, additional, Cisneros Barroso, Eugenia, additional, Rodríguez Rodríguez, Adrián, additional, Sanz, Monica, additional, Rigo Oliver, Elena, additional, González Moreno, Juan, additional, Gamez Martinez, Jose M, additional, Descals, Cristina, additional, Uson, Mercedes, additional, Jose Vega, Francisco, additional, Figuerola, Antoni, additional, Montala, Carles, additional, Dias da Silva, Moises, additional, Gervais de Santa Rosa, Renata, additional, Pinto, Luiz Felipe, additional, Pinto, Marcus Vinicius, additional, Cardoso Berensztejn, Amanda, additional, Barroso, Fabio, additional, Lautre, Andrea, additional, Orellana, Lucas G, additional, González-Duarte Briseño, Maria Alejandra, additional, Cárdenas-Soto, Karla, additional, Jiménez López, Brenda Poled, additional, Pérez-Castañeda, Sandra Lorena, additional, Cantú Brito, Carlos Gerardo, additional, Rivera de la Parra, David, additional, Hernandez Reyes, Jose Pablo, additional, del Mar Saniger Alba, Maria, additional, Criollo Mora, Elia, additional, Parman, Yesim, additional, Rezzan, Kus Jülide, additional, Sahin, Erdi, additional, Serbest, Nail G, additional, Durmus, Hacer, additional, Cakar, Arman, additional, Tugal Tutkun, Nuriye Ilknur, additional, Karamursel, Sacit, additional, Elitok, Ali, additional, Sirin Inan, Nermin G, additional, Altinkurt, Emre, additional, Ye, Jing, additional, Allen, Adriane C, additional, Chaudhry, Vinay, additional, Jarrett, Raquel, additional, Bressler, Neil, additional, Burks, Kathleen L, additional, Liu, Qingfeng, additional, Khoshnoodi, Mohammad, additional, Judge, Daniel P, additional, Vista, Geno, additional, Shah, Syed Mahmood, additional, Hamaguchi, Hirotoshi, additional, Oda, Junko, additional, Fukase, Emi, additional, Taniguchi, Ikuko, additional, Oda, Tetsuya, additional, Endo, Hironobu, additional, Shimomura, Masahiro, additional, Katanazaka, Kimitaka, additional, Koto, Shusuke, additional, Nakano, Takahiro, additional, Scheid, Christof, additional, Zueiter, Andreas, additional, Pester, Lars, additional, Walter, Doreen, additional, Özdemir, Betül, additional, Frenzel, Lukas F, additional, Holtick, Udo, additional, Oh, Jeeyoung, additional, Kim, Hee Jin, additional, Shin, Hyun Jin, additional, Choi, Kyomin, additional, Yamashita, Taro, additional, Masuda, Teruaki, additional, Misumi, Yohei, additional, Ueda, Akihiko, additional, Nakahara, Keiichi, additional, Yorita, Akiko, additional, Tsuruhisa, Seiko, additional, Taniwaki, Takayuki, additional, Harada, Masaya, additional, Moritaka, Taiga, additional, Sakurada, Naonori, additional, Mauricio, Elizabeth A, additional, Baskin, Amber, additional, Dimberg, Elliot, additional, Fonder, Amie, additional, Hobbs, Miriam, additional, Russell, Stephen J, additional, Dyck, Peter, additional, Gonsalves, Wilson, additional, Leung, Nelson, additional, Witzig, Thomas E, additional, Zeldenrust, Steven R, additional, Hwa, Lisa, additional, Kapoor, Prashant, additional, Kumar, Shaji K, additional, Lin, Yi, additional, Lust, John A, additional, Rajkumar, Vincent S, additional, Dingli, David, additional, Gertz, Morie A, additional, Go, Ronald, additional, Hayman, Suzanne R, additional, Dalia, Samir, additional, Carrillo, Esmeralda, additional, Gorevic, Peter, additional, Mason, Garnette, additional, Chao, Chi-Chao, additional, Lee, Ming-Jen, additional, Su, Jen-Jen, additional, Hsieh, Sung-Tsang, additional, Tsai, Li-Kai, additional, Yeh, Shin-Joe, additional, Yang, Chih-Chao, additional, Ajroud-Driss, Senda Ajroud-Driss, additional, Casey, Patricia, additional, Joslin, Benjamin C, additional, Freimer, Miriam, additional, Sankey, Alison, additional, Kenepp, Amanda, additional, Heintzman, Sarah, additional, LoRusso, Samantha, additional, Hokezu, Youichi, additional, Kim, Byoung-Joon, additional, Kim, JuHyeon, additional, Lee, Ga Yeon, additional, Cho, Eun Bin, additional, Jeon, Eun-Seok, additional, Min, Ju-Hong, additional, Seok, Jin Myoung, additional, Lee, Hye Lim, additional, Park, Jae Hong, additional, Sekijima, Yoshiki, additional, Miyazawa, Chinatsu, additional, Kato, Nagaaki, additional, Kishida, Dai, additional, Hineno, Akiyo, additional, Kodaira, Minori, additional, Yoshinaga, Tsuneaki, additional, Miyahara, Teruyoshi, additional, Imai, Akira, additional, Matsumoto, Kazuhiko, additional, Lin, Kon-Ping, additional, Lee, Yi-Chung, additional, Falk, Malin, additional, Pilebro, Bjorn, additional, Suhr, Ole, additional, Lindqvist, Per, additional, Soderberg, Karin, additional, Pedrosa-Domellöf, Fatima, additional, Anan, Intissar, additional, Nordh, Erik, additional, Tournev, Ivaylo, additional, Zhelyazkova-Glaveeva, Sashka, additional, Cherneva, Zheyna, additional, Sarafov, Staiko, additional, Chamova, Teodora, additional, Cherninkova-Gopina, Sylvia, additional, Friebel, Frauke, additional, Zibert, Andree, additional, Mihailovic, Natasa, additional, Schubert, Friederike, additional, Vorona, Elena, additional, Lahme, Larissa, additional, Huesing-Kabar, Anna, additional, Schilling, Matthias, additional, Kabar, Iyad, additional, Martinez-Naharro, Ana, additional, Chacko, Liza, additional, Cohen, Oliver, additional, Law, Steven, additional, Rezk, Tamer, additional, Lachmann, Helen J, additional, Blume, Brianna, additional, Dixon, Stacy, additional, Low, Soon Chai, additional, Chan, Soo Looi, additional, Lim, He Eng Li, additional, Goh, Khean Jin, additional, Kraus, Deborah, additional, Jack, Kristin, additional, Wade, N. Kevin, additional, Lopate, Glenn, additional, Zwijack, Brittany, additional, Florence, Julaine, additional, Sommerville, R. Brian, additional, Stewart, Graeme, additional, Ryder, Julie, additional, Mekhael, Linda, additional, Taylor, Mark, additional, Suan, Daniel, additional, Wells, Karen, additional, Stone, Paula, additional, Itoya, Amenze, additional, Owusu-Sekyere, Mercy, additional, Thai, Desmond, additional, Chahine, Ilonah, additional, Pedrosa, Salve, additional, and Do, Thi Hoa (Therese), additional
- Published
- 2021
- Full Text
- View/download PDF
49. COVID-19-related diffuse posthypoxic leukoencephalopathy and microbleeds masquerades as acute necrotizing encephalopathy
- Author
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Tristán-Samaniego, Dioselina Panamá, primary, Chiquete, Erwin, additional, Treviño-Frenk, Irene, additional, Rubalcava-Ortega, Johnatan, additional, Higuera-Calleja, Jesús Antonio, additional, Romero-Sánchez, Griselda, additional, Espinoza-Alvarado, Lissett, additional, Barrera-Vargas, Ana, additional, Flores-Silva, Fernando, additional, González-Duarte, Alejandra, additional, Vega-Boada, Felipe, additional, and Cantú-Brito, Carlos, additional
- Published
- 2020
- Full Text
- View/download PDF
50. Exploratory Analyses From Apollo-B, A Phase 3 Study Of Patisiran In Patients With Attr Amyloidosis With Cardiomyopathy
- Author
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Kale, Parag, Maurer, Mathew S, Fontana, Marianna, Grogan, Martha, Fernandes, Fábio, Palecek, Tomas, Taylor, Mark S, Hung, Rebecca R, Gonzalez-Duarte, Alejandra, Poulsen, Steen, Donal, Erwan, Perfetto, Federico, Tsujita, Kenichi, Yu, Wen-Chung, Sarswat, Nitasha, White, Matthew T, Arum, Seth, Jay, Patrick Y, Vest, John, and Gillmore, Julian
- Published
- 2023
- Full Text
- View/download PDF
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