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16 results on '"González-Cervera, Jesús"'

10. Wytyczne dotyczące rozpoznawania i postępowania w eozynofilowym zapaleniu przełyku u dzieci i dorosłych: oparte na faktach stwierdzenia i rekomendacje

Author

Lucendo, Alfredo J., primary, Molina-Infante, Javier, additional, Arias, Ángel, additional, Von Arnim, Ulrike, additional, Bredenoord, Albert J., additional, Bussmann, Christian, additional, Dias, Jorge Amil, additional, Bove, Mogens, additional, González-Cervera, Jesús, additional, Larsson, Helen, additional, Miehlke, Stephan, additional, Papadopoulou, Alexandra, additional, Rodríguez-Sánchez, Joaquín, additional, Ravelli, Alberto, additional, Ronkainen, Jukka, additional, Santander, Cecilio, additional, Schoepfer, Alain M., additional, Storr, Martin A., additional, Terreehorst, Ingrid, additional, Straumann, Alex, additional, and Attwood, Stephen E., additional

Published
2017
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11. Guidelines on eosinophilic esophagitis: evidence‐based statements and recommendations for diagnosis and management in children and adults

Author

Lucendo, Alfredo J, primary, Molina‐Infante, Javier, additional, Arias, Ángel, additional, von Arnim, Ulrike, additional, Bredenoord, Albert J, additional, Bussmann, Christian, additional, Amil Dias, Jorge, additional, Bove, Mogens, additional, González‐Cervera, Jesús, additional, Larsson, Helen, additional, Miehlke, Stephan, additional, Papadopoulou, Alexandra, additional, Rodríguez‐Sánchez, Joaquín, additional, Ravelli, Alberto, additional, Ronkainen, Jukka, additional, Santander, Cecilio, additional, Schoepfer, Alain M, additional, Storr, Martin A, additional, Terreehorst, Ingrid, additional, Straumann, Alex, additional, and Attwood, Stephen E, additional

Published
2017
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16. [Analysis of asthma control and quality of life in severe allergic asthmatics under treatment with anti-IgE, omalizumab].

Author

Pacheco-Galván A, Hinojosa-Macías M, Hurtado-Barbudo B, González-Cervera J, and Sueiro-Bendito A

Subjects
Adolescent, Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones therapeutic use, Adult, Aged, Anti-Asthmatic Agents administration & dosage, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal, Humanized, Asthma diagnosis, Asthma prevention & control, Data Interpretation, Statistical, Female, Humans, Male, Middle Aged, Omalizumab, Skin Tests, Surveys and Questionnaires, Time Factors, Treatment Outcome, Anti-Asthmatic Agents therapeutic use, Antibodies, Monoclonal therapeutic use, Asthma drug therapy, Quality of Life
Abstract

Background and Objectives: To evaluate anti-IgE (ie, omalizumab) efficacy on severe allergic asthma in order to achieve the efficacy of this treatment on severe allergic asthma progress by means of asthma control questionnaire (ACQ), asthma quality of life questionnaire (AQLQ) as well as pulmonary function (FEV1) and physician overall assessment., Patients and Methods: Fourteen patients were studied who suffered from severe allergic asthma for several years; average 20.7yr. A positive skin prick test or specific IgE antibodies to a common aeroallergen were observed in all patients who were under treatment with high doses of inhaled corticosteroids (eight of them also with oral corticosteroids). Omalizumab 150-600 mg were administrated once or twice monthly and each patient was monthly evaluated until sixteen weeks, deciding at this time which patient was or not responder in order to follow up or not omalizumab treatment., Results: Physician overall assessment improved in 11 out of every 14 patients. A marked improvement was observed at two months in ACQ and AQLQ (p<0.05) and at 3 and 4 moths only in AQLQ and AQLQ-symptoms respectively (p<0.05). The FEV1 improved by 9.4% average (p=0.24). Oral corticosteroids were reduced in 4 of 8 patients and in another one there was a definitive suspension. Two patients suffered adverse reactions which suspension of treatment despite the fact that they presented improvement in questionnaires of quality of life and control of asthma., Conclusions: Omalizumab showed a marked global efficacy in more than 3 out of 4 patients suffering severe allergic asthma as revealed by physician overall assessment. Moreover significant improvements were observed in ACQ; AQLQ; AQLQ-symptoms at 2, 3 and 4 months of treatment, without significant changes in FEV1 probably due to chronic irreversible changes in airways.

Published
2009
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