12 results on '"González-Fernández, Carolina"'
Search Results
2. Variations in tumor growth, intra-individual biological variability, and the interpretation of changes.
- Author
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Trapé, Jaume, Bérgamo, Silvia, González-Fernández, Carolina, Rives, José, and González-García, Laura
- Subjects
TUMOR growth ,TUMOR markers ,REFERENCE values ,CLINICAL pathology ,TIME measurements ,DISEASE progression - Abstract
The identification of changes in tumor markers (TMs) in cancer patients that indicate response to treatment, stabilization or disease progression is a challenge for laboratory medicine. Several approaches have been proposed: assessing percentage increases, applying discriminant values, and estimating half-life (t
1/2 ) or doubling time (DT). In all of them it is assumed that the TM is a surrogate of the variation in tumor size. In general this variation is time-dependent, but this is not the case of intraindividual biological variability (CVi), which can range from 6 % in CA15-3 to 22 % in CA125. When decisions are made on the basis of DT or t1/2 , these values can be affected by the CVi; if it is very large, the growth rate very slow and the period of time between determinations very short, the result obtained for DT may be due mainly to the CVi. The aim of this study is to establish the relationship between the CVi and temporal variables. We related equations for calculating DT and t1/2 to the reference change values in tumor markers. The application of the formula obtained allows the calculation of the optimal time between measurements to ensure that the influence of the CVi is minimal in different types of tumors and different scenarios. Intraindividual variation affects the calculation of DT and t1/2 . It is necessary to establish the minimum time between two measurements to ensure that the CVi does not affect their calculation or lead to misinterpretation. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
3. Lung cancer tumor markers in serous effusions and other body fluids.
- Author
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Trapé, Jaume, Bérgamo, Silvia, González-Garcia, Laura, and González-Fernández, Carolina
- Subjects
BODY fluids ,LUNG cancer ,PLEURAL effusions ,TUMOR markers ,LUNG tumors ,EXUDATES & transudates - Abstract
From its onset and during its progression, lung cancer may affect various extrapulmonary structures. These include the serous membranes, the pleura and pericardium, and less frequently the central nervous system, with leptomeningeal involvement. In these cases, fluid accumulates in the serous membranes which may contain substances secreted by the tumor. Measuring the concentrations of these substances can provide useful information for elucidating the origin of the fluid accumulation, either in pleural and pericardial effusions or in cerebrospinal fluid. This paper describes the histological types of lung cancer that most frequently affect the serosa and leptomeninges. It also reviews the literature on tumor markers in different fluids and makes recommendations for their interpretation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Factors influencing blood tumor marker concentrations in the absence of neoplasia.
- Author
-
Trapé, Jaume, Fernández-Galán, Esther, Auge, Josep Maria, Carbonell-Prat, Marina, Filella, Xavier, Miró-Cañís, Sílvia, and González-Fernández, Carolina
- Subjects
TUMOR markers ,HEMATOMA ,PROSTATE cancer ,CARCINOEMBRYONIC antigen ,PROSTATE-specific antigen ,VITAMIN K ,PEPTIDES - Abstract
BACKGROUND: Tumor markers (TMs) are a heterogeneous group of molecules used in the diagnosis, prognosis and follow-up of cancer patients. During neoplastic differentiation, cells can either directly synthesize or induce the synthesis of TMs, and the release of these molecules into the bloodstream allows their quantification in biological fluids. Although very small concentrations of TMs are usually present in the serum or plasma of healthy subjects, increased concentrations may also be found in the presence of benign diseases or due to technical interference, producing false positive results. MATERIAL AND METHODS AND RESULTS: Our review analyses the causes of false positives described between January 1970 to February 2023 for the TMs most frequently used in clinical practice: α-fetoprotein (AFP), β2-microglobulin (β2-M), cancer antigen 15-3 (CA 15-3), cancer antigen CA 19-9 (CA 19-9), cancer antigen CA 72-4 (CA 72-4), cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), chromogranin A (CgA), choriogonadotropin (hCG), cytokeratin 19 fragment (CYFRA 21-1), neuron-specific enolase (NSE), human epididymis protein 4 (HE4), serum HER2 (sHER2), squamous cell carcinoma antigen (SCCA), protein induced by vitamin K absence-II (PIVKA-II), Pro-gastrin-releasing peptide (Pro-GRP), prostate-specific antigen (PSA), Protein S-100 (S-100) and thyroglobulin (Tg). A total of 247 references were included. CONCLUSIONS: A better understanding of pathophysiological processes and other conditions that affect the concentration of TMs might improve the interpretation of results and their clinical application. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Lung cancer tumor markers in serous effusions and other body fluids
- Author
-
Trapé, Jaume, primary, Bérgamo, Silvia, additional, González-Garcia, Laura, additional, and González-Fernández, Carolina, additional
- Published
- 2022
- Full Text
- View/download PDF
6. Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
- Author
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Trinité, Benjamin, primary, Pradenas, Edwards, additional, Marfil, Silvia, additional, Rovirosa, Carla, additional, Urrea, Víctor, additional, Tarrés-Freixas, Ferran, additional, Ortiz, Raquel, additional, Rodon, Jordi, additional, Vergara-Alert, Júlia, additional, Segalés, Joaquim, additional, Guallar, Victor, additional, Lepore, Rosalba, additional, Izquierdo-Useros, Nuria, additional, Trujillo, Glòria, additional, Trapé, Jaume, additional, González-Fernández, Carolina, additional, Flor, Antonia, additional, Pérez-Vidal, Rafel, additional, Toledo, Ruth, additional, Chamorro, Anna, additional, Paredes, Roger, additional, Blanco, Ignacio, additional, Grau, Eulàlia, additional, Massanella, Marta, additional, Carrillo, Jorge, additional, Clotet, Bonaventura, additional, and Blanco, Julià, additional
- Published
- 2021
- Full Text
- View/download PDF
7. Comparative Assessment of Two Strategies for Interpreting Tumor Markers in Ascitic Effusions
- Author
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TRAPÉ, JAUME, primary, SANT, FRANCESC, additional, MONTESINOS, JESUS, additional, ARNAU, ANNA, additional, SALA, MARIA, additional, FIGOLS, CRISTINA, additional, FRANQUESA, JOSEFINA, additional, ESTEVE-VALVERDE, ENRIQUE, additional, PÉREZ, RAFEL, additional, ALIGUÉ, JORDI, additional, CATOT, SILVIA, additional, CASADO, ESTHER, additional, DOMENECH, MONTSERRAT, additional, TRAPÉ-UBEDA, JORDI, additional, BERGÓS, CARMEN, additional, VIDA, FRANSCESC, additional, SORT, PAU, additional, BONET, MARIONA, additional, RUIZ, DOMINGO, additional, GONZÁLEZ-FERNÁNDEZ, CAROLINA, additional, ORDEIG, JOSEP, additional, and MOLINA, RAFAEL, additional
- Published
- 2020
- Full Text
- View/download PDF
8. Complejidad y conservación de la quasiespecies del virus de la hepatitis B analizada mediante secuenciación masiva en el gen X. Asociación con la actividad replicativa e identificación de regiones híper-conservadas en el genoma viral
- Author
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González Fernández, Carolina, Rodríguez Frías, Francisco, Buti, Maria, Tabernero Caellas, David, and Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
- Subjects
HBX ,Hyper-conserved ,VHB ,Ciències Experimentals ,viruses ,HBV ,Híper-conservada ,Hiper-conservada ,digestive system diseases - Abstract
La proteína X del virus de la hepatitis B (HBx), codificada por el gen X de este virus (HBX), es crucial para la replicación del VHB y regula la expresión de múltiples genes del huésped. Por este motivo deben existir zonas altamente conservadas a nivel nucleotídico (HBX) y/o aminoacídico (HBx), esenciales para su actividad reguladora. Sin embargo, las inserciones y deleciones descritas en el extremo C-terminal de esta proteína, parecen limitar la posibilidad de que estas zonas estén en la región 3’ de HBX, por eso se ha escogido estudiar mediante la tecnología de secuenciación masiva la variabilidad del extremo 5’de HBX. En esta región se han identificado 2 regiones híper-conservadas, que además podrían ser utilizadas como potenciales dianas terapéuticas para una nueva estrategia de tratamiento antiviral basada en la terapia génica contra la HBx mediante el silenciamiento génico. Este tratamiento podría ser útil para conseguir la “cura funcional” de la infección en todos los estadios clínicos y en presencia de todos los genotipos virales. Además de la conservación del extremo 5’ de HBX en esta tesis también se ha estudiado en profundidad la complejidad y variantes específicas de la quasiespecies (QS) de esta región en pacientes en diferentes etapas clínicas de la infección crónica por el VHB HBeAg (-), para investigar su relación con los mecanismos que permiten controlar la replicación viral. El estudio de la complejidad y la variabilidad de la QS de un grupo de pacientes con infección crónica HBeAg (-) (IC) evidenció, en estos pacientes, una QS más conservada y compleja que en los pacientes con hepatitis crónica (en presencia o no de lesiones hepáticas como la cirrosis y el HCC), caracterizada por la presencia de un alto número de haplotipos altamente mutados probablemente a muy bajas frecuencias, por lo que no afectan a la conservación. Asimismo, se ha evidenciado un grupo de mutaciones genotipo-específicas. En concreto se ha descrito un patrón mutacional en los haplotipos de genotipo D de los IC asociado a una probable reducción de la expresión viral. Este patrón mutacional genotipo-específico evidencia la necesidad de genotipar adecuadamente el virus en el seguimiento de los pacientes infectados por VHB. En resumen, el extremo 5’de HBX contiene regiones híper-conservadas que podrían ser esenciales para la función de la HBx y explotadas como diana para el tratamiento antiviral basado en terapia génica. Además la QS de los pacientes IC presenta características diferenciales de complejidad y conservación. Estas características junto con patrones de mutaciones genotipo-específicas, podrían estar relacionados con la baja replicación del VHB en estos pacientes. The hepatitis B virus X protein (HBx), encoded by the X gene of this virus (HBX), is crucial for HBV replication and regulates the expression of multiple host genes. For this reason, there must be highly conserved areas at nucleotide (HBX) and/or amino acid (HBx) level, essential for its regulatory activity. However, the insertions and deletions described in the C-terminal end of this protein seem to limit the possibility that these areas are located in the 3’ region of HBX. By this reason, the 5’-end of HBX has been chosen to study its conservation by next-generation sequencing. In this region, 2 hyper-conserved regions have been identified. These regions could be used as potential therapeutic targets for a new antiviral treatment strategy, based on gene therapy against HBx through gene silencing. This treatment could be useful to achieve “functional cure” of the HBV infection in all clinical stages and in the presence of all viral genotypes. In addition to the conservation of the 5’ end of HBX, in this thesis the complexity and specific variants of the quasispecies (QS) of this region have also been studied in depth in patients at different clinical stages of HBeAg (-) chronic HBV infection, to investigate its relationship with the mechanisms that allow to control viral replication. The study of the complexity and variability of the QS of a group of patients with HBeAg (-) chronic infection (IC) showed a more conserved and complex QS in these patients than in patients with chronic hepatitis (with or without liver lesion such liver cirrhosis and HCC), characterized by the presence of a high number of highly mutated haplotypes, probably at very low frequencies, so they do not affect conservation. Likewise, a group of genotype-specific mutations has been evidenced. In particular, a mutational pattern has been described in genotype D haplotypes of IC patients, probably associated with a reduction of viral expression. This genotype-specific mutational pattern demonstrates the need to adequately genotype the virus in the HBV infected patients follow-up. In summary, the 5’-end of HBX contains hyper-conserved regions that could be essential for the HBx function and could be exploited as a target for antiviral treatment based on gene therapy. In addition, the IC patients’ QS presents differential characteristics of complexity and conservation. These characteristics, together with patterns of genotype-specific mutations, could be related to the low replication of HBV in these patients.
- Published
- 2019
9. Diagnostic Accuracy of CYFRA21-1 in the Differential Diagnosis of Pleural Effusions
- Author
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TRAPÉ, JAUME, primary, SANT, FRANCESC, additional, MONTESINOS, JESUS, additional, ARNAU, ANNA, additional, SALA, MARIA, additional, BERNADICH, OSCAR, additional, MARTÍN, ESPERANZA, additional, PERICH, DAMIA, additional, LOPEZ, JOAN, additional, ROS, SANDRA, additional, ESTEVE-VALVERDE, ENRIQUE, additional, PÉREZ, RAFAEL, additional, GONZÁLEZ-FERNÁNDEZ, CAROLINA, additional, ALIGUE, JORDI, additional, CATOT, SILVIA, additional, DOMENECH, MONTSERRAT, additional, RUIZ, DOMINGO, additional, BONET, MARIONA, additional, MOLINA, RAFAEL, additional, and ORDEIG, JOSEP, additional
- Published
- 2019
- Full Text
- View/download PDF
10. Contribución al estudio de la profilaxis del sarampión por la globulina placentaria y sangre materna
- Author
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González Fernández, Carolina
- Subjects
Xarampió Espanya - Published
- 1943
11. Factors influencing blood tumor marker concentrations in the absence of neoplasia.
- Author
-
Trapé J, Fernández-Galán E, Auge JM, Carbonell-Prat M, Filella X, Miró-Cañís S, and González-Fernández C
- Subjects
- Male, Humans, Antigens, Neoplasm analysis, Keratin-19, Carcinoembryonic Antigen, Prostate-Specific Antigen, Phosphopyruvate Hydratase, CA-125 Antigen, Biomarkers, Tumor, Lung Neoplasms pathology
- Abstract
Background: Tumor markers (TMs) are a heterogeneous group of molecules used in the diagnosis, prognosis and follow-up of cancer patients. During neoplastic differentiation, cells can either directly synthesize or induce the synthesis of TMs, and the release of these molecules into the bloodstream allows their quantification in biological fluids. Although very small concentrations of TMs are usually present in the serum or plasma of healthy subjects, increased concentrations may also be found in the presence of benign diseases or due to technical interference, producing false positive results., Material and Methods and Results: Our review analyses the causes of false positives described between January 1970 to February 2023 for the TMs most frequently used in clinical practice: α-fetoprotein (AFP), β2-microglobulin (β2-M), cancer antigen 15-3 (CA 15-3), cancer antigen CA 19-9 (CA 19-9), cancer antigen CA 72-4 (CA 72-4), cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), chromogranin A (CgA), choriogonadotropin (hCG), cytokeratin 19 fragment (CYFRA 21-1), neuron-specific enolase (NSE), human epididymis protein 4 (HE4), serum HER2 (sHER2), squamous cell carcinoma antigen (SCCA), protein induced by vitamin K absence-II (PIVKA-II), Pro-gastrin-releasing peptide (Pro-GRP), prostate-specific antigen (PSA), Protein S-100 (S-100) and thyroglobulin (Tg). A total of 247 references were included., Conclusions: A better understanding of pathophysiological processes and other conditions that affect the concentration of TMs might improve the interpretation of results and their clinical application.
- Published
- 2024
- Full Text
- View/download PDF
12. Lung cancer tumor markers in serous effusions and other body fluids.
- Author
-
Trapé J, Bérgamo S, González-Garcia L, and González-Fernández C
- Subjects
- Humans, Biomarkers, Tumor analysis, Ascitic Fluid, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Body Fluids, Pericardial Effusion chemistry, Pericardial Effusion pathology, Pleural Effusion pathology, Pleural Effusion, Malignant pathology
- Abstract
From its onset and during its progression, lung cancer may affect various extrapulmonary structures. These include the serous membranes, the pleura and pericardium, and less frequently the central nervous system, with leptomeningeal involvement. In these cases, fluid accumulates in the serous membranes which may contain substances secreted by the tumor. Measuring the concentrations of these substances can provide useful information for elucidating the origin of the fluid accumulation, either in pleural and pericardial effusions or in cerebrospinal fluid. This paper describes the histological types of lung cancer that most frequently affect the serosa and leptomeninges. It also reviews the literature on tumor markers in different fluids and makes recommendations for their interpretation.
- Published
- 2024
- Full Text
- View/download PDF
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