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11 results on '"González-Hernández, Mariana"'

1. Comparison of two antibody screening systems for SARS-CoV-2 antibody detection in recovered and vaccinated subjects - test performance and possible indicators for immunity

Author

Jonczyk, Rebecca, Stanislawski, Nils, Seiler, Lisa K., Ahani, Somayeh, Bueltemeier, Arne, Stahl, Frank, Beutel, Sascha, Blume, Holger, Hauß, Corinna, Melk, Anette, Paulsen, Mira, Stiesch, Meike, Winkel, Andreas, Pott, Philipp-Cornelius, Saletti, Giulietta, González-Hernández, Mariana, Kaiser, Franziska Karola, Rimmelzwaan, Guus F., Osterhaus, Albert D.M.E., and Blume, Cornelia

Published
2022
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2. An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

Author

Du, Wenjuan, primary, Hurdiss, Daniel L., additional, Drabek, Dubravka, additional, Mykytyn, Anna Z., additional, Kaiser, Franziska K., additional, González-Hernández, Mariana, additional, Muñoz-Santos, Diego, additional, Lamers, Mart M., additional, van Haperen, Rien, additional, Li, Wentao, additional, Drulyte, Ieva, additional, Wang, Chunyan, additional, Sola, Isabel, additional, Armando, Federico, additional, Beythien, Georg, additional, Ciurkiewicz, Malgorzata, additional, Baumgärtner, Wolfgang, additional, Guilfoyle, Kate, additional, Smits, Tony, additional, van der Lee, Joline, additional, van Kuppeveld, Frank J. M., additional, van Amerongen, Geert, additional, Haagmans, Bart L., additional, Enjuanes, Luis, additional, Osterhaus, Albert D. M. E., additional, Grosveld, Frank, additional, and Bosch, Berend-Jan, additional

Published
2022
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3. An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

Author

Virologie, dI&I I&I-1, Bedrijfsvoering, Du, Wenjuan, Hurdiss, Daniel L, Drabek, Dubravka, Mykytyn, Anna Z, Kaiser, Franziska K, González-Hernández, Mariana, Muñoz-Santos, Diego, Lamers, Mart M, van Haperen, Rien, Li, Wentao, Drulyte, Ieva, Wang, Chunyan, Sola, Isabel, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Baumgärtner, Wolfgang, Guilfoyle, Kate, Smits, Tony, van der Lee, Joline, van Kuppeveld, Frank J M, van Amerongen, Geert, Haagmans, Bart L, Enjuanes, Luis, Osterhaus, Albert D M E, Grosveld, Frank, Bosch, Berend-Jan, Virologie, dI&I I&I-1, Bedrijfsvoering, Du, Wenjuan, Hurdiss, Daniel L, Drabek, Dubravka, Mykytyn, Anna Z, Kaiser, Franziska K, González-Hernández, Mariana, Muñoz-Santos, Diego, Lamers, Mart M, van Haperen, Rien, Li, Wentao, Drulyte, Ieva, Wang, Chunyan, Sola, Isabel, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Baumgärtner, Wolfgang, Guilfoyle, Kate, Smits, Tony, van der Lee, Joline, van Kuppeveld, Frank J M, van Amerongen, Geert, Haagmans, Bart L, Enjuanes, Luis, Osterhaus, Albert D M E, Grosveld, Frank, and Bosch, Berend-Jan

Published
2022

4. Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany

Author

Jonczyk, Rebecca, Stanislawski, Nils, Seiler, Lisa K., Blume, Holger, Heiden, Stefanie, Lucas, Henning, Sarikouch, Samir, Pott, Philipp-Cornelius, Stiesch, Meike, Hauß, Corinna, Saletti, Giulietta, González-Hernández, Mariana, Kaiser, Franziska Karola, Rimmelzwaan, Guus, Osterhaus, Albert, Blume, Cornelia, Jonczyk, Rebecca, Stanislawski, Nils, Seiler, Lisa K., Blume, Holger, Heiden, Stefanie, Lucas, Henning, Sarikouch, Samir, Pott, Philipp-Cornelius, Stiesch, Meike, Hauß, Corinna, Saletti, Giulietta, González-Hernández, Mariana, Kaiser, Franziska Karola, Rimmelzwaan, Guus, Osterhaus, Albert, and Blume, Cornelia

Abstract

Despite lockdown measures, intense symptom-based PCR, and antigen testing, the SARS-CoV-2 pandemic spread further. In this open observational study conducted in Lower Saxony, Germany, voluntary SARS-CoV-2 PCR tests were performed from April 2020 until June 2021, supported by serum antibody testing to prove whether PCR testing in subjects with none or few symptoms of COVID-19 is a suitable tool to manage the pandemic. In different mobile stations, 4,817 subjects from three different working fields participated in the PCR testing. Serum antibody screening using the SARS-CoV-2 ViraChip IgG (Viramed, Germany) and the Elecsys Anti-SARS-CoV-2 assay (Roche, Germany) was performed alongside virus neutralization testing. Subjects were questioned regarding comorbidities and COVID-19 symptoms. Fifty-one subjects with acute SARS-CoV-2 infection were detected of which 31 subjects did not show any symptoms possibly characteristic for COVID-19. An additional 37 subjects reported a previous SARS-CoV-2 infection (total prevalence 1.82%). Seroconversion was discovered in 58 subjects with known SARS-CoV-2 infection and in 58 subjects that never had a positive PCR test. The latter had a significantly lower Charlson Comorbidity Index, and one third of them were asymptomatic. In 50% of all seroconverted subjects, neutralizing serum antibodies (NAbs) were detectable in parallel to N/S1 (n = 16) or N/S1/S2 antigen specific antibodies (n = 40) against SARS-CoV-2. NAb titers decreased within 100 days after PCR-confirmed SARS-CoV-2 acute infection by at least 2.5-fold. A relatively high rate of subclinical SARS-CoV-2 infections may contribute to the spread of SARS-CoV-2, suggesting that in addition to other intervention strategies, systematic screening of asymptomatic persons by PCR testing may significantly enable better pandemic control.

Published
2022

5. Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany

Author

Jonczyk, Rebecca, primary, Stanislawski, Nils, additional, Seiler, Lisa K., additional, Blume, Holger, additional, Heiden, Stefanie, additional, Lucas, Henning, additional, Sarikouch, Samir, additional, Pott, Philipp-Cornelius, additional, Stiesch, Meike, additional, Hauß, Corinna, additional, Saletti, Giulietta, additional, González-Hernández, Mariana, additional, Kaiser, Franziska Karola, additional, Rimmelzwaan, Guus, additional, Osterhaus, Albert, additional, and Blume, Cornelia, additional

Published
2022
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10. The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies

Author

Brinkmann, Constantin, primary, Nehlmeier, Inga, additional, Walendy-Gnirß, Kerstin, additional, Nehls, Julia, additional, González Hernández, Mariana, additional, Hoffmann, Markus, additional, Qiu, Xiangguo, additional, Takada, Ayato, additional, Schindler, Michael, additional, and Pöhlmann, Stefan, additional

Published
2016
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