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302 results on '"Goodrich, Laurie R."'

4. A Pilot Study to Assess the Safety and Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stromal Cells for the Treatment of Synovitis in Horses.

Author

Seabaugh, Kathryn, Rao, Sangeeta, Koenig, Judith B., Pezzanite, Lynn, Dow, Steven, Koch, Thomas G., Russell, Keith A., Mehrpouyan, Sahar, Alizadeh, A. Hamed, and Goodrich, Laurie R.

Subjects
JOINT capsule, LAMENESS in horses, INTRA-articular injections, STROMAL cells, UMBILICAL cord
Abstract

Simple Summary: Synovitis frequently affects joints in horses and can result in lameness. Synovitis results in joint capsule distention and inflammation of the joint environment, which can lead to more serious complications, such as osteoarthritis, if not addressed early. Researchers are searching for a treatment to interrupt this progression and address the synovitis prior to osteoarthritis developing. We present a study that assesses the safety and efficacy of a single administration of 10 million cryopreserved allogeneic mesenchymal stromal cells (MSC) that were either activated (aMSC) or non-activated (naMSC) for the treatment of synovitis. The front or hind fetlock or a single joint of the carpus in 24 client-owned horses were split into two groups. Both MSC treatments resulted in positive clinical outcomes. When evaluating from Day 0 to Day 42, naMSC-treated horses improved by 0.79 lameness grades and aMSC-treated horses improved by 1.25 lameness grades. There was no significant difference between the two treatments for any outcome parameter. Owners were contacted at 12 and 18 weeks after treatment. All fifteen owners who returned questionnaires at 12 weeks were satisfied with their horses' response to treatment. Eighteen of the twenty-three questionnaires that were returned at Week 18 indicated that the owners were satisfied with their horses' response to treatment. Synovitis is present before and during osteoarthritis in horses and can result in performance-limiting lameness. Twenty-four horses with lameness localized to the metacarpo-/metatarsophalangeal joint or a single joint of the carpus were enrolled in this study. We evaluated the response of intra-articular injection with 10 million activated (aMSC) or non-activated (naMSC) allogeneic equine umbilical cord blood-derived mesenchymal stromal cells (MSCs). Subjective and objective lameness was assessed on Days 0, 1, 21, and 42. The treatment injection was randomly assigned and performed following the baseline assessment on Day 0. naMSC-treated horses had straight-line lameness scores that were significantly lower on Day 21 (1.0 ± 1.15) and Day 42 (1.13 ± 1.00) than on Day 0 (p = 0.0098 and p = 0.0418, respectively). aMSC-treated horses had straight-line lameness scores that were significantly lower on Day 21 (0.96 ± 1.03) and Day 42 (0.79 ± 1.05) than on Day 0 (p = 0.0011 and p < 0.0001, respectively). There was no significant difference between the treatment groups for any parameter at any timepoint. In conclusion, both aMSC and naMSC allogeneic MSCs resulted in significantly improved subjective lameness scores in horses when compared to baseline lameness scores. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Longitudinal in vivo cationic contrast‐enhanced computed tomography classifies equine articular cartilage injury and repair.

Author

Nelson, Brad B., Mäkelä, Janne T. A., Lawson, Taylor B., Patwa, Amit N., Snyder, Brian D., McIlwraith, C. Wayne, Grinstaff, Mark W., Seabaugh, Kathryn A., Barrett, Myra F., Goodrich, Laurie R., and Kawcak, Christopher E.

Subjects
ARTICULAR cartilage, SYNOVIAL membranes, SYNOVIAL fluid, CONTRAST media, HISTOLOGY
Abstract

Cationic contrast‐enhanced computed tomography (CECT) capitalizes on increased contrast agent affinity to the charged proteoglycans in articular cartilage matrix to provide quantitative assessment of proteoglycan content with enhanced images. While high resolution microCT has demonstrated success, we investigate cationic CECT use in longitudinal in vivo imaging at clinical resolution. We hypothesize that repeated administration of CA4+ will have no adverse side effects or complications, and that sequential in vivo imaging assessments will distinguish articular cartilage repair tissue from early degenerative and healthy cartilage in critically sized chondral defects. In an established equine translational preclinical model, lameness and synovial effusion scores are similar to controls after repeated injections of CA4+ (eight injections over 16 weeks) compared to controls. Synovial fluid total protein, leukocyte concentration, and sGAG and PGE2 concentrations and articular cartilage and synovial membrane scores are also equivalent to controls. Longitudinal in vivo cationic CECT attenuation in repair tissue is significantly lower than peripheral to (adjacent) and distantly from defects (remote sites) by 4 weeks (p < 0.001), and this difference persists until 16 weeks. At the 6‐ and 8‐week time points, the adjacent locations exhibit significantly lower cationic CECT attenuation compared with the remote sites, reflecting peri‐defect degeneration (p < 0.01). Cationic CECT attenuation at clinical resolution significantly correlates with cationic CECT (microCT) (r = 0.69, p < 0.0001), sGAG (r = 0.48, p < 0.0001), and ICRS II histology score (r = 0.63, p < 0.0001). In vivo cationic CECT imaging at clinical resolution distinguishes fibrous repair tissue from degenerative and healthy hyaline cartilage and correlates with molecular tissue properties of articular cartilage. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Use of quantitative mass spectrometry-based proteomics and ELISA to compare the alpha 2 macroglobulin concentration in equine blood-based products processed by three different orthobiologic devices

Author

Ortved, Kyla F., primary, Alward, Larry, additional, Cowles, Bobby, additional, Linardi, Renata, additional, Barot, Dhvani, additional, Usimaki, Alex, additional, Fedie, Joseph R., additional, Amodie, Deb, additional, and Goodrich, Laurie R., additional

Published
2024
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10. Proceedings of the signature series symposium “cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies—promise, facts and fantasy,” international society for cellular therapies, montreal, canada, may 2, 2018

Author

Piuzzi, NICOLAS S., DOMINICI, MASSIMO, LONG, MARC, PASCUAL-GARRIDO, CECILIA, RODEO, SCOTT, HUARD, JOHNNY, GUICHEUX, JÉROME, MCFARLAND, RICHARD, GOODRICH, LAURIE R., MADDENS, STÉPHANE, ROBEY, PAMELA G., BAUER, THOMAS W, BARRETT, JOHN, BARRY, FRANK, KARLI, DAVID, CHU, CONSTANCE R., WEISS, DANIEL J., MARTIN, IVAN, JORGENSEN, CHRISTIAN, and MUSCHLER, GEORGE F.

Published
2018
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18. Distinct differences in immunological properties of equine orthobiologics revealed by functional and transcriptomic analysis using an activated macrophage readout system

Author

Pezzanite, Lynn M., Chow, Lyndah, Griffenhagen, Gregg M., Bass, Luke, Goodrich, Laurie R., Impastato, Renata, and Dow, Steven

Subjects
General Veterinary
Abstract

IntroductionMultiple biological therapies for orthopedic injuries are marketed to veterinarians, despite a lack of rigorous comparative biological activity data to guide informed decisions in selecting a most effective compound. Therefore, the goal of this study was to use relevant bioassay systems to directly compare the anti-inflammatory and immunomodulatory activity of three commonly used orthobiological therapies (OTs): mesenchymal stromal cells (MSC), autologous conditioned serum (ACS), and platelet rich plasma (PRP).MethodsEquine monocyte-derived macrophages were used as the readout system to compare therapies, including cytokine production and transcriptomic responses. Macrophages were stimulated with IL-1ß and treated 24 h with OTs, washed and cultured an additional 24 h to generate supernatants. Secreted cytokines were measured by multiplex immunoassay and ELISA. To assess global transcriptomic responses to treatments, RNA was extracted from macrophages and subjected to full RNA sequencing, using an Illumina-based platform. Data analysis included comparison of differentially expressed genes and pathway analysis in treated vs. untreated macrophages.ResultsAll treatments reduced production of IL-1ß by macrophages. Secretion of IL-10 was highest in MSC-CM treated macrophages, while PRP lysate and ACS resulted in greater downregulation of IL-6 and IP-10. Transcriptomic analysis revealed that ACS triggered multiple inflammatory response pathways in macrophages based on GSEA, while MSC generated significant downregulation of inflammatory pathways, and PRP lysate induced a mixed immune response profile. Key downregulated genes in MSC-treated cultures included type 1 and type 2 interferon response, TNF-α and IL-6. PRP lysate cultures demonstrated downregulation of inflammation-related genes IL-1RA, SLAMF9, ENSECAG00000022247 but concurrent upregulation of TNF-α, IL-2 signaling, and Myc targets. ACS induced upregulation of inflammatory IL-2 signaling, TNFα and KRAS signaling and hypoxia, but downregulation of MTOR signaling and type 1 interferon signaling.DiscussionThese findings, representing the first comprehensive look at immune response pathways for popular equine OTs, reveal distinct differences between therapies. These studies address a critical gap in our understanding of the relative immunomodulatory properties of regenerative therapies commonly used in equine practice to treat musculoskeletal disease and will serve as a platform from which further in vivo comparisons may build.

Published
2023
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21. A Polymer Network Architecture Provides Superior Cushioning and Lubrication of Soft Tissue Compared to a Linear Architecture

Author

Cooper, Benjamin G, primary, DeMoya, Christian D., additional, Sikes, Katie J., additional, Frisbie, David D., additional, Phillips, Nikki, additional, Nelson, Brad B., additional, McIlwraith, C. Wayne, additional, Kawcak, Chris E., additional, Goodrich, Laurie R., additional, Snyder, Brian D., additional, and Grinstaff, Mark W., additional

Published
2023
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24. Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference

Author

Chu, Constance R., Rodeo, Scott, Bhutani, Nidhi, Goodrich, Laurie R., Huard, Johnny, Irrgang, James, LaPrade, Robert F., Lattermann, Christian, Lu, Ying, Mandelbaum, Bert, Mao, Jeremy, McIntyre, Louis, Mishra, Allan, Muschler, George F., Piuzzi, Nicolas S., Potter, Hollis, Spindler, Kurt, Tokish, John M., Tuan, Rocky, Zaslav, Kenneth, and Maloney, William

Published
2019
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26. TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant Staphylococcal septic arthritis in an equine model

Author

Pezzanite, Lynn M., primary, Chow, Lyndah, additional, Phillips, Jennifer, additional, Griffenhagen, Gregg M., additional, Moore, A. Russell, additional, Schaer, Thomas P., additional, Engiles, Julie B., additional, Werpy, Natasha, additional, Gilbertie, Jessica, additional, Schnabel, Lauren V., additional, Antczak, Doug, additional, Miller, Donald, additional, Dow, Steven, additional, and Goodrich, Laurie R., additional

Published
2022
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31. Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation

Author

Kearney, Clodagh M., primary, Khatab, Sohrab, additional, van Buul, Gerben M., additional, Plomp, Saskia G. M., additional, Korthagen, Nicoline M., additional, Labberté, Margot C., additional, Goodrich, Laurie R., additional, Kisiday, John D., additional, Van Weeren, P. R., additional, van Osch, Gerjo J. V. M., additional, and Brama, Pieter A. J., additional

Published
2022
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32. Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation

Author

Kearney, Clodagh M, Khatab, Sohrab, van Buul, Gerben M, Plomp, Saskia G M, Korthagen, Nicoline M, Labberté, Margot C, Goodrich, Laurie R, Kisiday, John D, Van Weeren, P R, van Osch, Gerjo J V M, Brama, Pieter A J, Kearney, Clodagh M, Khatab, Sohrab, van Buul, Gerben M, Plomp, Saskia G M, Korthagen, Nicoline M, Labberté, Margot C, Goodrich, Laurie R, Kisiday, John D, Van Weeren, P R, van Osch, Gerjo J V M, and Brama, Pieter A J

Published
2022

33. Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation

Author

Kearney, Clodagh M., Khatab, Sohrab, van Buul, Gerben M., Plomp, Saskia G.M., Korthagen, Nicoline M., Labberté, Margot C., Goodrich, Laurie R., Kisiday, John D., Van Weeren, P. R., van Osch, Gerjo J.V.M., Brama, Pieter A.J., Kearney, Clodagh M., Khatab, Sohrab, van Buul, Gerben M., Plomp, Saskia G.M., Korthagen, Nicoline M., Labberté, Margot C., Goodrich, Laurie R., Kisiday, John D., Van Weeren, P. R., van Osch, Gerjo J.V.M., and Brama, Pieter A.J.

Published
2022

34. Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation

Author

Equine Musculoskeletal Biology, CS_Locomotion, Dep Clinical Sciences, Kearney, Clodagh M, Khatab, Sohrab, van Buul, Gerben M, Plomp, Saskia G M, Korthagen, Nicoline M, Labberté, Margot C, Goodrich, Laurie R, Kisiday, John D, Van Weeren, P R, van Osch, Gerjo J V M, Brama, Pieter A J, Equine Musculoskeletal Biology, CS_Locomotion, Dep Clinical Sciences, Kearney, Clodagh M, Khatab, Sohrab, van Buul, Gerben M, Plomp, Saskia G M, Korthagen, Nicoline M, Labberté, Margot C, Goodrich, Laurie R, Kisiday, John D, Van Weeren, P R, van Osch, Gerjo J V M, and Brama, Pieter A J

Published
2022

37. Contributors

Author

Barrett, Myra F., primary, Brama, Pieter A.J., additional, de Grauw, Janny C., additional, Frisbie, David D., additional, Goodrich, Laurie R., additional, Haussler, Kevin K., additional, Kawcak, Christopher E., additional, King, Melissa R., additional, McIlwraith, C. Wayne, additional, Selberg, Kurt, additional, van Weeren, P. René, additional, and Werpy, Natasha M., additional

Published
2016
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39. Contributors

Author

Adair, Steve, Allen, Kate, Art, Tatiana, Bayly, Warwick M., Beard, Laurie, Benoit, Philippe H., Bertone, Alicia L., Birch, Helen L., Bubeck, Kirstin A., Carr, Elizabeth A., Cheetham, Jonathan, Cobbold, Felicity, Contino, Erin K., Couetil, Laurent L., Courouce-Malblanc, Anne, Cardoso de Mira, Monica, Decloedt, Annelies, Dockery, Allison, Ducharme, Norm G., Emerson, Mark, Faramarzi, Babak, Fiedler, Julie, Foreman, Jonathan H., Franklin, Samantha H., Geffroy, Olivier, Geor, Raymond J., Gilger, Brian, Gillis, Carol, Goodrich, Laurie R., Goodship, Allen E., Hamilton, Natasha Anne, Harris, Patricia A., Hernlund, Elin, Hinchcliff, Kenneth W., Lee Hitchens, Peta, Holbrook, Todd C., Jansson, Anna, Jose-Cunilleras, Eduard, Kallings, Peter L., Kaneps, Andris J., Katz, Lisa M., Léguillette, Renaud, Leleu, Claire, Lindinger, Michael I., Maher, Omar, Matthews, Andrew, McBride, Sebastian D., McCutcheon, L. Jill, McKenzie, Erica, Morrice-West, Ashleigh, Muir, Tessa I., Murray, Rachel C., Nath, Laura C., Nelson, Brad B., Oosterlinck, Maarten, Piercy, Richard J., Puccetti, Massimo, Rhodin, Marie, Rivero, José-Luis L., Robert, Celine, Rossignol, Fabrice, Schoonover, Mike J., Serra Bragança, Filipe M., Sinclair, Charlotte, Slater, Josh, Smith, Roger K.W., Starke, Sandra, Steel, Cate, Sykes, Ben, Sykes, David, Ursini, Tena, van Erck-Westergren, Emmanuelle, van Galen, Gaby, van Loon, Gunther, Van Weeren, P. René, Votion, Dominique-M., Waller, Amanda P., Whitton, Chris, and Williams, Cooper

Published
2024
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42. Contributors

Author

Abutarbush, Sameeh M., primary, Aceto, Helen, additional, Affolter, Verena K., additional, Albanese, Valeria, additional, Aleman, Monica, additional, Allen, Kate, additional, Allen, Kent, additional, Alvarenga, Marco Antonio, additional, Andrews, Frank M., additional, Annear, Matthew, additional, Banse, Heidi, additional, Barrett, Elizabeth J., additional, Bauck, Anje G., additional, Beard, Laurie A., additional, Beard, Warren, additional, Belgrave, Rodney L., additional, Blanchard, Terry L., additional, Blott, Sarah, additional, Brandt, Sabine, additional, Branson, Keith R., additional, Brink, Palle, additional, Brockus, Charles W., additional, Brown, James A., additional, Buchanan, Benjamin R., additional, Buhl, Rikke, additional, Burba, Daniel J., additional, Burden, Faith, additional, Burns, Teresa A., additional, Camacho-Luna, Pilar, additional, Canisso, Igor F., additional, Carlson, Kelly L., additional, Carr, Elizabeth A., additional, Chapman, Hannah-Sophie, additional, Claes, Anthony, additional, Clayton, Hilary M., additional, Clode, Alison B., additional, Coleman, Michelle C., additional, Contino, Erin K., additional, Cook, R. Frank, additional, Cook, Vanessa L., additional, Corley, Kevin T., additional, Cullinane, Ann, additional, Coutinho da Silva, Marco A., additional, Dahlgren, Linda A., additional, Dart, Andrew J., additional, Davidson, Elizabeth J., additional, Davis, Elizabeth, additional, Dechant, Julie E., additional, Diaz-Méndez, Andrés, additional, Divers, Thomas J., additional, du Toit, Nicole, additional, Dunkel, Bettina, additional, Durham, Matthew G., additional, Dyson, Sue, additional, Eastman, Tim G., additional, Elton, Debra, additional, Epstein, Kira L., additional, Estell, Krista E., additional, Ewart, Susan L., additional, Ferris, Ryan A., additional, Fielding, C. Langdon, additional, Finan, Seán A., additional, Finno, Carrie J., additional, Fowlie, Jennifer, additional, Frank, Nicholas, additional, Franklin, Samantha H., additional, Frazer, Michele L., additional, Freeman, David E., additional, Furr, Martin, additional, Garrett, Katherine S., additional, Gilger, Brian C., additional, Gillis, Carol L., additional, Gimenez, Rebecca M., additional, Giuliano, Elizabeth A., additional, Goehring, Lutz S., additional, Goodrich, Laurie R., additional, Graves, Emily A., additional, Guthrie, Alan J., additional, Hackett, Eileen S., additional, Hahn, Caroline, additional, Hainisch, Edmund K., additional, Hanson, R. Reid, additional, Hart, Kelsey A., additional, Haussler, Kevin K., additional, Henninger, Rick W., additional, Hogan, Patricia M., additional, Hollis, Anna R., additional, Hurcombe, Samuel D.A., additional, Issel, Charles J., additional, Jesty, Sophy A., additional, Johnson, Amy L., additional, Johnson, Philip J., additional, Jokisalo, Jonna M., additional, Kamm, J. Lacy, additional, Katz, Lisa Michelle, additional, Knych, Heather K., additional, Labelle, Amber L., additional, Lacombe, Véronique A., additional, Landolt, Gabriele A., additional, Léguillette, Renaud, additional, Leutenegger, Christian M., additional, Lorch, Gwendolen, additional, Losinno, Luis, additional, Lugo, Joel, additional, Macpherson, Margo L., additional, Madigan, John E., additional, Magdesian, K. Gary, additional, Mair, Tim, additional, Mama, Khursheed R., additional, Marsella, Rosanna, additional, Mason, Clara Ann, additional, Matthews, Nora S., additional, McCarrel, Taralyn M., additional, McCluskey, Brian J., additional, McConnico, Rebecca S., additional, McCracken, Jeanette L., additional, McCue, Patrick M., additional, McGorum, Bruce C., additional, McGurrin, M. Kimberly J., additional, McKenzie, Harold C., additional, McKinnon, Angus O., additional, McNabb, Noelle T., additional, Meindel, Mandy J., additional, Mendes, Luiz Claudio Nogueira, additional, Millerick-May, Melissa L., additional, Morehead, James P., additional, Morresey, Peter R., additional, Morrison, Scott E., additional, Morton, Alison J., additional, Mowat, Freya M., additional, Murray, Rachel C., additional, Natalini, Claudio C., additional, Nelson, Brad B., additional, Neto, Carlos Ramires, additional, Newcombe, John R., additional, Newton, J. Richard, additional, Nielsen, Martin K., additional, O'Brien, Philippa, additional, O'Grady, Stephen E., additional, O'Neill, Henry D., additional, Oosterlinck, Maarten, additional, Paccamonti, Dale L., additional, Page, Allen E., additional, Papa, Frederico Ozanam, additional, Parkin, Tim D.H., additional, Parks, Andrew H., additional, Pease, Anthony P., additional, Peek, Simon F., additional, Pelzel-McCluskey, Angela M., additional, Perkins, Justin D., additional, Peroni, John F., additional, Peters, Duncan F., additional, Petersen, Annette, additional, Phillips, Jeffrey, additional, Plummer, Caryn E., additional, Powell, Sarah E., additional, Pozor, Malgorzata, additional, Prange, Timo, additional, Puschner, Birgit, additional, Pusterla, Nicola, additional, Pynn, Oliver D., additional, Ragle, Claude A., additional, Rashmir-Raven, Ann, additional, Reed, Stephen M., additional, Richter, Ruth-Anne, additional, Robinson, N. Edward, additional, Rombach, Nicole, additional, Ruggles, Alan J., additional, Runcan, Erin E., additional, Schott, Harold C., additional, Schroeder, Eric L., additional, Schumacher, John, additional, Schumacher, Stephen A., additional, Scoggin, Charles F., additional, Sellon, Debra C., additional, Sherlock, Ceri, additional, Sinclair, Charlotte, additional, Sinclair, Melissa, additional, Slovis, Nathan, additional, Soboll Hussey, Gisela, additional, Spier, Sharon J., additional, Sponseller, Beatrice T., additional, Sprayberry, Kim A., additional, Stack, Alice, additional, Stick, John, additional, Stover, Susan M., additional, Stratford, Claire H., additional, Stubbs, Narelle Colleen, additional, Taintor, Jennifer S., additional, Thiemann, Alexandra K., additional, Timoney, John F., additional, Toribio, Ramiro E., additional, Tranquille, Carolyne A., additional, Traub-Dargatz, Josie L., additional, Tulloch, Laura K., additional, Utter, Mary Lassaline, additional, van den Top, Gerald, additional, Varner, Dickson D., additional, Viel, Laurent, additional, von Schweinitz, Dietrich Graf, additional, Waldridge, Bryan M., additional, Walker, Vicki A., additional, Watts, Ashlee E., additional, Werner, Laura A., additional, Weyer, Camilla T., additional, White, Stephen D., additional, Wilkerson, Melinda J., additional, Wilkins, Pamela A., additional, Wilson, M. Eilidh, additional, Wilson, Pamela J., additional, Witte, Thomas H., additional, Wong, David M., additional, and Yiannikouris, Stavros, additional

Published
2015
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44. List of contributors

Author

ALLEN, KATE, primary, ANDERSON, BRIAN, additional, ART, TATIANA, additional, BARREY, ERIC, additional, BASSAGE, LANCE H., additional, BAYLY, WARWICK, additional, BELL, BRENDON, additional, BERGH, ANNA, additional, BERTONE, ALICIA L., additional, BIRCH, HELEN L., additional, BODEN, LISA, additional, CARR, ELIZABETH A., additional, CHEETHAM, JON, additional, COUETIL, LAURENT L., additional, COUROUCÉ-MALBLANC, ANNE, additional, DANIEL, ALEXANDER J., additional, DUCHARME, NORM G., additional, ELLIS, PATRICIA M., additional, ERICKSON, HOWARD H., additional, FELDMANN, HILLARY, additional, FOREMAN, JONATHAN H., additional, FRANKLIN, SAMANTHA, additional, GEOR, RAYMOND J., additional, GILLIS, CAROL, additional, GIRAUDET, AUDE, additional, GOFF, LESLEY, additional, GOODRICH, LAURIE R., additional, GOODSHIP, ALLEN E., additional, HARDY, JOANNE, additional, HARRIS, PATRICIA A., additional, HAUSSLER, KEVIN K., additional, HINCHCLIFF, KENNETH W., additional, HOLBROOK, TODD C., additional, HOLCOMBE, SUSAN J., additional, HUBBELL, JOHN A.E., additional, IRELAND, JO L., additional, JEFFCOTT, LEO B., additional, JOSE-CUNILLERAS, EDUARD, additional, KANEPS, ANDRIS J., additional, KAWCAK, CHRISTOPHER E., additional, KEEGAN, KEVIN G., additional, KIRKER-HEAD, CARL A., additional, KRAMER, JOANNE, additional, LINDINGER, MICHAEL, additional, LORENZO-FIGUERAS, MIREIA, additional, LUMSDEN, JONATHAN M., additional, McCUTCHEON, L. JILL, additional, MCGOWAN, CATHERINE M., additional, MCKEEVER, KENNETH HARRINGTON, additional, MCKENZIE, ERICA C., additional, MAHER, OMAR, additional, MERRITT, ALFRED M., additional, MORLEY, PAUL S., additional, MURRAY, RACHEL C., additional, NATH, LAURA C., additional, NELSON, BRAD B., additional, NIETO, JORGE, additional, O'SULLIVAN, CHRISTOPHER B., additional, PARKIN, TIM, additional, PIERCY, RICHARD J., additional, PILSWORTH, ROB, additional, POOLE, DAVID C., additional, PUSTERLA, NICOLA, additional, RIGGS, CHRISTOPHER M., additional, RITMEESTER, ANDREA, additional, RIVERO, JOSÉ-LUIS L., additional, ROBERT, CÉLINE, additional, SCHWARZWALD, COLIN C., additional, SINCLAIR, CHARLOTTE, additional, SMITH, ROGER K.W., additional, STEWART, BRIAN D., additional, VAN DER KOLK, JOHANNES H., additional, VAN ERCK-WESTERGREN, EMMANUELLE, additional, VAN LOON, GUNTHER, additional, VAN WEEREN, RENÉ, additional, VOTION, DOMINIQUE, additional, WHITTON, CHRIS, additional, and YOUNG, LESLEY E., additional

Published
2014
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46. Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity

Author

Pezzanite, Lynn, primary, Chow, Lyndah, additional, Hendrickson, Dean, additional, Gustafson, Daniel L., additional, Russell Moore, A, additional, Stoneback, Jason, additional, Griffenhagen, Gregg M., additional, Piquini, Gabriella, additional, Phillips, Jennifer, additional, Lunghofer, Paul, additional, Dow, Steven, additional, and Goodrich, Laurie R., additional

Published
2021
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