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2. Written language achievement in children and adolescents with neurofibromatosis type 1 and Plexiform Neurofibromas.

Author

Siegel, Atara, Toledo-Tamula, Mary Anne, Martin, Staci, Gillespie, Andy, Goodwin, Anne, Widemann, Brigitte, and Wolters, Pamela L.

Abstract

Neurofibromatosis type 1 (NF1) is associated with below average writing achievement. However, little is known about specific aspects of written language impacted by NF1, changes in writing over time, and associations between cognitive aspects of the NF1 phenotype and writing. At three timepoints over six years, children with NF1 and plexiform neurofibromas (PNs) completed Woodcock-Johnson tests of writing mechanics (Spelling, Punctuation & Capitalization, handwriting), written expression of ideas (Writing Samples), writing speed (Writing Fluency), and tests of general cognitive ability, executive function, memory, and attention. Children (N = 76, mean age = 12.8 ± 3.4 years) completed at least one baseline writing subtest. Overall writing scores were in the Average range (M = 93.4, SD = 17.4), but lower than population norms (p = 0.002). Scores were highest on Writing Samples (M = 95.2, SD = 17.3), and lowest for Punctuation & Capitalization (M = 87.9, SD = 18.8, p = 0.034). Writing scores were mostly stable over time. Nonverbal reasoning was related to some tests of writing mechanics and written expression of ideas. Short-term memory and inattention explained additional variance in Writing Samples and Spelling. Poor handwriting was associated with writing content beyond the impact of cognitive factors. Children with NF1 and PNs may benefit from early screening and writing support. Interventions should address the contribution of both cognitive and handwriting difficulties in written language. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Longitudinal association between executive function and academic achievement in children with neurofibromatosis type 1 and plexiform neurofibromas.

Author

Hou, Yang, Wu, Xian, Allen, Taryn, Toledo-Tamula, Mary Anne, Martin, Staci, Gillespie, Andy, Goodwin, Anne, Widemann, Brigitte C., and Wolters, Pamela L.

Subjects
EXECUTIVE function, PERFORMANCE in children, NEUROFIBROMATOSIS 1, ACADEMIC achievement, RESPONSE inhibition
Abstract

Objective: To examine how executive functioning (EF) relates to academic achievement longitudinally in children with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PNs) and whether age at baseline moderates this relationship. Method: Participants included 88 children with NF1 and PNs (ages 6–18 years old, M = 12.05, SD = 3.62, 50 males) enrolled in a natural history study. Neuropsychological assessments were administered three times over 6 years. EF (working memory, inhibitory control, cognitive flexibility, and attention) was assessed by performance-based (PB) and parent-reported (PR) measures. Multilevel growth modeling was used to examine how EF at baseline related to initial levels and changes in broad math, reading, and writing across time, controlling for demographic variables. Results: The relationship between EF and academic achievement varied across EF and academic domains. Cognitive flexibility (PB) uniquely explained more variances in initial math, reading, and writing scores; working memory (PB) uniquely explained more variances in initial levels of reading and writing. The associations between EF and academic achievement tended to remain consistent across age groups with one exception: Lower initial levels of inhibitory control (PR) were related to a greater decline in reading scores. This pattern was more evident among younger (versus older) children. Conclusions: Findings emphasize the heterogeneous nature of academic development in NF1 and that EF skills could help explain the within-group variability in this population. Routine cognitive/academic monitoring via comprehensive assessments and early targeted treatments consisting of medication and/or systematic cognitive interventions are important to evaluate for improving academic performance in children with NF1 and PNs. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Demographic and Disease-Related Predictors of Socioemotional Development in Children with Neurofibromatosis Type 1 and Plexiform Neurofibromas: An Exploratory Study

Author

Hou, Yang, primary, Wu, Xian, additional, Liu, Dan, additional, Martin, Staci, additional, Toledo-Tamula, Mary Anne, additional, Allen, Taryn, additional, Baldwin, Andrea, additional, Gillespie, Andy, additional, Goodwin, Anne, additional, Widemann, Brigitte C., additional, and Wolters, Pamela L., additional

Published
2022
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9. Phase II Trial of Pirfenidone in Children and Young Adults With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas

Author

Widemann, Brigitte C., Babovic-Vuksanovic, Dusica, Dombi, Eva, Wolters, Pamela L., Goldman, Stewart, Martin, Staci, Goodwin, Anne, Goodspeed, Wendy, Kieran, Mark W., Cohen, Bruce, Blaney, Susan M., King, Allison, Solomon, Jeffrey, Patronas, Nicholas, Balis, Frank M., Fox, Elizabeth, Steinberg, Seth M., and Packer, Roger J

Published
2014
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14. Cediranib phase‐II study in children with metastatic alveolar soft‐part sarcoma (ASPS)

Author

Cohen, Julia W., primary, Widemann, Brigitte C., additional, Derdak, Joanne, additional, Dombi, Eva, additional, Goodwin, Anne, additional, Dompierre, Jessica, additional, Onukwubiri, Uzoma, additional, Steinberg, Seth M., additional, O'Sullivan Coyne, Geraldine, additional, Kummar, Shivaani, additional, Chen, Alice P., additional, and Glod, John, additional

Published
2019
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15. Oh, brave new world of parenthood!

Author

Goodwin, Anne L.

Subjects
Parenthood -- Laws, regulations and rules, Parent and child (Law) -- Analysis, Human reproductive technology -- Laws, regulations and rules
Published
1994

21. PLANETARY PROBLEMS.

Author

GRASSE, SELINA, TAIT, HILARY, CHRISTIANSEN, DEIDRE, HASTINGS, PAM, CASELEY, ANDREW, FITZGIBBON, S., FENTON, PATRICIA, ESPERSEN, ANDY, RYAN, ELIZABETH, HOPCROFT, JULIE, and GOODWIN, ANNE

Published
2020

22. Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas

Author

Jakacki, Regina I., primary, Dombi, Eva, additional, Steinberg, Seth M., additional, Goldman, Stewart, additional, Kieran, Mark W., additional, Ullrich, Nicole J., additional, Pollack, Ian F., additional, Goodwin, Anne, additional, Manley, Peter E., additional, Fangusaro, Jason, additional, Allen, Rudy, additional, and Widemann, Brigitte C., additional

Published
2016
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25. Early detection of transformation of plexiform neurofibromas to malignant peripheral nerve sheath tumors in neurofibromatosis type 1.

Author

Bhaumik, Sucharita, primary, Stewart, Douglas, additional, Pemov, Alexander, additional, Choyke, Peter L., additional, Dombi, Eva, additional, Glod, John, additional, Miettinen, Markku, additional, Khan, Javed, additional, Steinberg, Seth M, additional, Goodwin, Anne, additional, Baldwin, Andrea, additional, and Widemann, Brigitte C., additional

Published
2015
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28. Abundance and diversity of ascidians in the southern Gulf of Chiriquí, Pacific Panama

Author

Bullard, Stephan G., Carman, Mary R., Rocha, Rosana M., Dijkstra, Jennifer A., Goodwin, Anne M., Bullard, Stephan G., Carman, Mary R., Rocha, Rosana M., Dijkstra, Jennifer A., and Goodwin, Anne M.

Abstract

© The Author(s), 2011. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Aquatic Invasions 6 (2011): 381-390, doi:10.3391/ai.2011.6.4.03., Little is known about the ascidian fauna of Pacific Panama. Ascidian surveys were conducted in the southern Gulf of Chiriquí on the Pacific coast of Panama in January 2008 and 2009. Surveys along linear transects at 2-3 m depth (snorkel, 2008) and 5 and 12 m depth (SCUBA, 2009) were conducted at multiple sites within a chain of islands extending out from the mainland. Twelve different ascidian taxa were observed with mean densities of up to ~17 ascidians m-2. The most abundant species was Rhopalaea birkelandi. Two of the most abundant taxa (Ascidia sp., Pyura sp.) appear to represent previously undescribed species. Several species of didemnids were also abundant. Ascidians were most abundant near the coast of the mainland and were less abundant near the islands farthest offshore. These data on Panamanian ascidian communities provide a baseline of local biodiversity against which it will be possible to determine whether the communities change over time, if additional species become introduced to the region, or if native Panamanian species become invasive in other parts of the world., This research was supported by Ocean Life Institute Exploratory Grant (250513.38) to Carman and Sievert, Tropical Research Initiative Grant (253750.09) to Carman, Molyneaux and Sievert, a University of Hartford International Center Faculty Grant to Bullard, and CNPq senior postdoctoral grant to Rocha (200914/2008-1).

Published
2012

29. Ascidians at the Pacific and Atlantic entrances to the Panama Canal

Author

Carman, Mary R., Bullard, Stephan G., Rocha, Rosana M., Lambert, Gretchen, Dijkstra, Jennifer A., Roper, James J., Goodwin, Anne M., Carman, Mimi M., Vail, Elisabete M., Carman, Mary R., Bullard, Stephan G., Rocha, Rosana M., Lambert, Gretchen, Dijkstra, Jennifer A., Roper, James J., Goodwin, Anne M., Carman, Mimi M., and Vail, Elisabete M.

Abstract

© The Author(s), 2011. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Aquatic Invasions 6 (2011): 371-380, doi:10.3391/ai.2011.6.4.02., The Panama Canal region is susceptible to non-native species introductions due to the heavy international shipping traffic through the area. Ascidian introductions are occurring worldwide but little is known about introductions at the Panama Canal. Surveys were conducted in 2002, 2008, and 2009 within the Pacific and Atlantic entrances to the canal. We found a high diversity of ascidians on both sides of the canal, dominated by non-native species; six species occurred at both Pacific and Atlantic Panama sites. This is the first report of Polyandrocarpa anguinea and P. sagamiensis in Atlantic Panama waters and Ascidia incrassata, Ascidia sydneiensis, Botrylloides nigrum, Botryllus planus, Didemnum perlucidum, Diplosoma listerianum, Microcosmus exasperatus, Polyandrocarpa zorritensis, Polyclinum constellatum, Symplegma brakenhielmi, Symplegma rubra, and Trididemnum orbiculatum in Pacific Panama waters. The canal may serve as a major invasion corridor for ascidians and should be monitored over time., Funding for this project came from WHOI Ocean Life Institute-Tropical Research Initiative to Carman and CNPq to Rocha.

Published
2012

30. Phase I trial and pharmacokinetic (PK) study of satraplatin in children and young adults with refractory solid tumors including brain tumors.

Author

Akshintala, Srivandana, primary, Marcus, Leigh, additional, Warren, Katherine E., additional, Murphy, Robert F., additional, Goodspeed, Wendy J., additional, Goodwin, Anne, additional, Brewer, Carmen C., additional, Zalewski, Christopher, additional, King, Kelly A., additional, Kim, AeRang, additional, and Widemann, Brigitte C., additional

Published
2013
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33. A Phase 1 Trial and Pharmacokinetic Study of Cediranib, an Orally Bioavailable Pan–Vascular Endothelial Growth Factor Receptor Inhibitor, in Children and Adolescents With Refractory Solid Tumors

Author

Fox, Elizabeth, primary, Aplenc, Richard, additional, Bagatell, Rochelle, additional, Chuk, Meredith K., additional, Dombi, Eva, additional, Goodspeed, Wendy, additional, Goodwin, Anne, additional, Kromplewski, Marie, additional, Jayaprakash, Nalini, additional, Marotti, Marcelo, additional, Brown, Kathryn H., additional, Wenrich, Barbara, additional, Adamson, Peter C., additional, Widemann, Brigitte C., additional, and Balis, Frank M., additional

Published
2010
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34. Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group

Author

Widemann, Brigitte C., primary, Arceci, Robert J., additional, Jayaprakash, Nalini, additional, Fox, Elizabeth, additional, Zannikos, Peter, additional, Goodspeed, Wendy, additional, Goodwin, Anne, additional, Wright, John J., additional, Blaney, Susan M., additional, Adamson, Peter C., additional, and Balis, Frank M., additional

Published
2010
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35. Phase II Trial of Ixabepilone Administered Daily for Five Days in Children and Young Adults with Refractory Solid Tumors: A Report from the Children's Oncology Group

Author

Jacobs, Shana, primary, Fox, Elizabeth, additional, Krailo, Mark, additional, Hartley, Gwen, additional, Navid, Fariba, additional, Wexler, Leonard, additional, Blaney, Susan M., additional, Goodwin, Anne, additional, Goodspeed, Wendy, additional, Balis, Frank M., additional, Adamson, Peter C., additional, and Widemann, Brigitte C., additional

Published
2010
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37. Abstract A5: Phase I trial and pharmacokinetic study of cediranib in children with recurrent or refractory solid tumors

Author

Fox, Elizabeth, primary, Aplenc, Richard, additional, Widemann, Brigitte, additional, Chuk, Meredith, additional, Bagatell, Rochelle, additional, Goodwin, Anne, additional, Goodspeed, Wendy, additional, Kromplewski, Marie, additional, Wenrich, Barbara, additional, Brown, Kathryn H., additional, Marotti, Marcelo, additional, Adamson, Peter C., additional, and Balis, Frank M., additional

Published
2009
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40. A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors

Author

Fox, Elizabeth, primary, Maris, John M., additional, Widemann, Brigitte C., additional, Goodspeed, Wendy, additional, Goodwin, Anne, additional, Kromplewski, Marie, additional, Fouts, Molly E., additional, Medina, Diane, additional, Cohn, Susan L., additional, Krivoshik, Andrew, additional, Hagey, Anne E., additional, Adamson, Peter C., additional, and Balis, Frank M., additional

Published
2008
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44. A Phase 1 Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 7 Days Every 21 Days in Pediatric Patients with Solid Tumors

Author

Fox, Elizabeth, primary, Maris, John M., additional, Widemann, Brigitte C., additional, Meek, Kysa, additional, Goodwin, Anne, additional, Goodspeed, Wendy, additional, Kromplewski, Marie, additional, Fouts, Molly E., additional, Medina, Diane, additional, Cho, Steve Y., additional, Cohn, Susan L., additional, Krivoshik, Andrew, additional, Hagey, Anne E., additional, Adamson, Peter C., additional, and Balis, Frank M., additional

Published
2006
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47. Vessel Maturation and Perivascular Cells.

Author

Marmé, Dieter, Fusenig, Norbert, Goodwin, Anne M., and D'Amore, PatriciaA.

Abstract

Maturation of new vessels involves interaction of vascular endothelial cells with surrounding mural cells, namely smooth muscle cells or pericytes. In this chapter we will focus on the role of pericytes, as well as the various factors secreted by pericytes, in promoting microvascular growth, differentiation and function. We will discuss perivascular cell contributions to blood-neural barrier function and fenestrations, specialized phenotypes of microvascular endothelial cells. Finally, we will address clinical implications of pericyte function and vessel maturation in cancer, diabetic retinopathy and therapeutic angiogenesis. [ABSTRACT FROM AUTHOR]

Published
2008
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