561 results on '"Gooley, Paul R."'
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2. Analysis of mechanisms of the rabies virus P protein-nucleocapsid interaction using engineered N-protein peptides and potential applications in antivirals design
3. Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1
4. Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant
5. Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome.
6. Encounter Complexes Between the N-terminal of Neurotensin with the Extracellular Loop 2 of the Neurotensin Receptor 1 Steer Neurotensin to the Orthosteric Binding Pocket
7. NMR applications to GPCR recognition by peptide ligands
8. High yield expression and purification of full-length Neurotensin with pyroglutamate modification
9. Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)
10. Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
11. The Monomeric α-Crystallin Domain of the Small Heat-shock Proteins αB-crystallin and Hsp27 Binds Amyloid Fibril Ends
12. The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome
13. Machine learning and multi-omics in precision medicine for ME/CFS.
14. Characterizing Conformational Diversity of G Protein-coupled Receptors by Solution NMR Spectroscopy
15. Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2
16. N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation
17. The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement
18. Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches
19. Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface
20. Identification of a Novel Subtype-Selective α1B-Adrenoceptor Antagonist
21. In vitro B cell experiments explore the role of CD24, CD38, and energy metabolism in ME/CFS
22. RNA Binding Properties of SOX Family Members.
23. Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
24. The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting
25. Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies
26. Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
27. 1H, 15N and 13C resonance assignments of the C-terminal domain of the P protein of the Nishigahara strain of rabies virus
28. Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics
29. Molecular Insights into the Enigmatic Metabolic Regulator, SnRK1
30. Expression and Purification of a Functional E. coli 13CH3-Methionine-Labeled Thermostable Neurotensin Receptor 1 Variant for Solution NMR Studies
31. Identification of a Novel Subtype-Selective α1B-Adrenoceptor Antagonist.
32. Regulation of Starch Stores by a Ca2+-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii
33. The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation
34. Physical characterisation of high amylose maize starch and acylated high amylose maize starches
35. Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)
36. Hydrodynamic radii of solubilized high amylose native and modified starches by pulsed field gradient NMR diffusion measurements
37. The Role of Select Subtype Polymorphisms on HIV-1 Protease Conformational Sampling and Dynamics
38. Applications of NMR and ITC for the Study of the Kinetics of Carbohydrate Binding by AMPK β-Subunit Carbohydrate-Binding Modules
39. The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome
40. The dynamic nature of neurotensin receptor 1 (NTS1) allostery and signaling bias
41. Systematic Review of NMR-Based Metabolomics Practices in Human Disease Research
42. The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation
43. Identification and characterization of bi-thiazole-2,2′-diamines as kinase inhibitory scaffolds
44. Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients
45. NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome
46. A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis
47. Acylation-dependent and-independent membrane targeting and distinct functions of small myristoylated proteins (SMPs) in Leishmania major
48. AMP-Activated Protein Kinase β-Subunit Requires Internal Motion for Optimal Carbohydrate Binding
49. Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis
50. Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant
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