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137 results on '"Gopal, Sandeep"'

1. Assessment of the comparative agreement between chest radiographs and CT scans in intensive care units

Author

Brooks, Daniel, Wright, Stephen E., Beattie, Anna, McAllister, Nadia, Anderson, Niall H., Roy, Alistair I., Gonsalves, Philip, Yates, Bryan, Graziadio, Sara, Mackie, Alasdair, Davidson, John, Gopal, Sandeep Vijaya, Whittle, Robert, Zahed, Asef, Barton, Lorna, Elameer, Mathew, Tuckett, John, Holmes, Rob, Sutcliffe, Alexandra, Santamaria, Nuria, de Lalouviere, Luke la Hausse, Gupta, Sanjay, Subramaniam, Jeevan, Pearson, Janaki A., Brandwood, Matthew, Burnham, Richard, Rostron, Anthony J., and Simpson, A. John

Published
2024
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7. Calcium in Cell-Extracellular Matrix Interactions

Author

Gopal, Sandeep, Multhaupt, Hinke A. B., Couchman, John R., Cohen, Irun R., Editorial Board Member, Lajtha, Abel, Editorial Board Member, Lambris, John D., Series Editor, Paoletti, Rodolfo, Editorial Board Member, Rezaei, Nima, Series Editor, and Islam, Md. Shahidul, editor

Published
2020
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10. The Synergistic Role of Integrated Computed Tomography and Magnetic Resonance Cholangiopancreatography in Disorders of the Pancreatobiliary System.

Author

Rai, Santosh, Srivastava, Saubhagya, Gopal, Sandeep, and Tiku, Anika

Subjects
BILIOUS disease diagnosis, CHOLANGIOGRAPHY, CROSS-sectional method, MAGNETIC resonance imaging, RETROSPECTIVE studies, PANCREATIC diseases, COMPARATIVE studies, DESCRIPTIVE statistics, COMPUTED tomography, SENSITIVITY & specificity (Statistics), RECEIVER operating characteristic curves, DATA analysis software, PROBABILITY theory
Abstract

Objective The aim of the study was to evaluate the synergistic role and advantages of integrating noncontrast computed tomography (NCCT) and magnetic resonance cholangiopancreatography (MRCP) in disorders of the pancreatobiliary (PB) system. Methods In this cross-sectional and retrospective record-based study, radiological (NCCT and MRCP) data were collected retrospectively for a period of 3 years (June 2018–August 2020) from 52 patients. The results were compared to the final diagnosis on endoscopic retrograde cholangiopancreatography (ERCP) findings (gold standard). The data collected were analyzed by measuring the sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy, and p -value for NCCT, MRCP, and integrated NCCT plus MRCP at different cutoff points. Subsequently, a receiver operating characteristic (ROC) curve was plotted to analyze different thresholds for NCCT, MRCP, and integrated NCCT plus MRCP. Results The most common pathologies identified were biliary dilations (18.4%), common bile duct (CBD) calculi (13.6%), and biliary strictures (12.0%). Overall, MRCP provided a higher percentage of correct diagnoses (81.6%) compared to CT (56.0%). Integrating NCCT with MRCP showed a significant increase in sensitivities and specificities when compared to NCCT or MRCP alone. Integrated NCCT plus MRCP showed excellent performance with an area under the curve (AUC) of ROC analysis of 0.937. Conclusion Our study showed that integrating NCCT and MRCP can prove to be an excellent tool in establishing a detailed diagnosis of PB disorders, better than either NCCT or MRCP alone. Due to the concurrent nature of PB disorders, it may be worth considering integrating NCCT and MRCP, given that there is an absence of contraindications to either modality. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Efficacy and validity of image-guided percutaneous fine needle aspiration and core biopsy of liver pathologies: Saga of focal hepatic lesions from the nodule to the needle to the slide.

Author

Rai, Santosh, Kumar, Vinay, Basavaiah, Sridevi, Sreeram, Saraswathy, Gopal, Sandeep, and Tantry, Bailuru

Subjects
LIVER, CYTODIAGNOSIS, ENDOSCOPIC surgery, RETROSPECTIVE studies, TERTIARY care, DIAGNOSTIC imaging, HOSPITAL wards, DESCRIPTIVE statistics, CYTOLOGY, NEEDLE biopsy
Abstract

Context: Radiology and pathology are pivotal tools in the investigational artillery for management of wide spectrum of hepatic lesions and early detection is of a paramount importance. Aims: The study aimed at analyzing the efficacy, comparative yield and validity of image-guided aspiration cytology (FNA)/core biopsy (CB) in focal hepatic lesions. Settings and Design: A retrospective hospital-based study was conducted in departments of Pathology and Radiology and Imaging of a tertiary care center. Materials and Methods: Cases of focal hepatic lesions that underwent percutaneous image guided-FNA reported (2011-2018) were analyzed. Cytological-histopathological correlation was performed where available. FNA diagnoses were divided into four categories-positive for malignancy (group 1), atypical (group 2), negative for malignancy (group 3), and non-diagnostic (group 4). Statistical Analysis Used: Categorical data was depicted in the form of frequencies and proportions. Validity of percutaneous image-guided FNA diagnosis was collated with the final diagnosis and results were analyzed. Results: A total of 338 FNA of focal hepatic lesions were reported in which 217 (68.2%) cases in group 1; 21 (6.2%) in group 2; 58 (17.2%) in group 3 and 42 (12.4%) in group 4. CB correlation was available in 123 cases. Based on clinical, radiological and pathological findings, conclusive final diagnoses were obtained and the cases were regrouped [malignant cases-245, benign lesions-57 and uncertain lesions-36]. Metastasis was the most common malignancy (175/245; 71.4%). Sensitivity, specificity, and overall diagnostic accuracy of FNA to categorize the lesion as benign or malignant were 96.94%, 100% and 97.51%, respectively. However, the cytology-histopathology correlation revealed discordance of subtyping the lesion in 20% of cases and sensitivity and specificity reduced to 80% and 50% respectively in rendering the specific diagnosis. Conclusions: Percutaneous image-guided FNA is a sensitive and specific tool with high diagnostic accuracy in evaluating focal hepatic lesions. The study highlights the pre-eminence of interventional radiology and cytology in the care of patients with liver lesions. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Fibronectin-guided migration of carcinoma collectives

Author

Gopal, Sandeep, primary, Veracini, Laurence, additional, Grall, Dominique, additional, Butori, Catherine, additional, Schaub, Sébastien, additional, Audebert, Stéphane, additional, Camoin, Luc, additional, Baudelet, Emilie, additional, Radwanska, Agata, additional, Beghelli-de la Forest Divonne, Stéphanie, additional, Violette, Shelia M., additional, Weinreb, Paul H., additional, Rekima, Samah, additional, Ilie, Marius, additional, Sudaka, Anne, additional, Hofman, Paul, additional, and Van Obberghen-Schilling, Ellen, additional

Published
2017
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42. Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour

Author

Couchman, John R, Gopal, Sandeep, Lim, Hooi Ching, Nørgaard, Steffen, and Multhaupt, Hinke AB

Subjects
Inflammation, Mice, Knockout, animal structures, Syndecans, Genotype, Protein Conformation, Receptors, Cell Surface, Review Article, Ligands, carbohydrates (lipids), Structure-Activity Relationship, Phenotype, Neoplasms, embryonic structures, Animals, Humans, Signal Transduction
Abstract

In the 25 years, as the first of the syndecan family was cloned, interest in these transmembrane proteoglycans has steadily increased. While four distinct members are present in mammals, one is present in invertebrates, including C. elegans that is such a powerful genetic model. The syndecans, therefore, have a long evolutionary history, indicative of important roles. However, these roles have been elusive. The knockout in the worm has a developmental neuronal phenotype, while knockouts of the syndecans in the mouse are mild and mostly limited to post-natal rather than developmental effects. Moreover, their association with high-affinity receptors, such as integrins, growth factor receptors, frizzled and slit/robo, have led to the notion that syndecans are coreceptors, with minor roles. Given that their heparan sulphate chains can gather many different protein ligands, this gave credence to views that the importance of syndecans lay with their ability to concentrate ligands and that only the extracellular polysaccharide was of significance. Syndecans are increasingly identified with roles in the pathogenesis of many diseases, including tumour progression, vascular disease, arthritis and inflammation. This has provided impetus to understanding syndecan roles in more detail. It emerges that while the cytoplasmic domains of syndecans are small, they have clear interactive capabilities, most notably with the actin cytoskeleton. Moreover, through the binding and activation of signalling molecules, it is likely that syndecans are important receptors in their own right. Here, an overview of syndecan structure and function is provided, with some prospects for the future.

Published
2014

45. Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels

Author

Gopal, Sandeep, primary, Søgaard, Pernille, additional, Multhaupt, Hinke A.B., additional, Pataki, Csilla, additional, Okina, Elena, additional, Xian, Xiaojie, additional, Pedersen, Mikael E., additional, Stevens, Troy, additional, Griesbeck, Oliver, additional, Park, Pyong Woo, additional, Pocock, Roger, additional, and Couchman, John R., additional

Published
2015
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47. Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

Author

Subesinghe, Manil, primary, Scarsbrook, Andrew F, additional, Sourbron, Steven, additional, Wilson, Daniel J, additional, McDermott, Garry, additional, Speight, Richard, additional, Roberts, Neil, additional, Carey, Brendan, additional, Forrester, Roan, additional, Gopal, Sandeep Vijaya, additional, Sykes, Jonathan R, additional, and Prestwich, Robin JD, additional

Published
2015
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50. On the Roles and Regulation of Chondroitin Sulfate and Heparan Sulfate in Zebrafish Pharyngeal Cartilage Morphogenesis

Author

Holmborn, Katarina, primary, Habicher, Judith, additional, Kasza, Zsolt, additional, Eriksson, Anna S., additional, Filipek-Gorniok, Beata, additional, Gopal, Sandeep, additional, Couchman, John R., additional, Ahlberg, Per E., additional, Wiweger, Malgorzata, additional, Spillmann, Dorothe, additional, Kreuger, Johan, additional, and Ledin, Johan, additional

Published
2012
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