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29 results on '"Gopala Krishna, B."'

15. Validation of a prediction score model to distinguish acute coronary syndromes from other conditions causing raised cardiac troponin T levels

Author

Charles van Heyningen, Gopala Krishna B. Rao, Yawer Saeed, Derek R. Robinson, Peter Sze Chai Wong, and Antony Leslie Innasimuthu

Subjects
Male, medicine.medical_specialty, Acute coronary syndrome, Time Factors, Comorbidity, Logistic regression, Risk Assessment, Sensitivity and Specificity, Angina Pectoris, Diagnosis, Differential, Hospitals, University, Electrocardiography, Troponin T, Predictive Value of Tests, Risk Factors, Internal medicine, Atrial Fibrillation, Odds Ratio, Medicine, Humans, Myocardial infarction, Hospital Mortality, Prospective Studies, Acute Coronary Syndrome, Prospective cohort study, Aged, ST depression, Aged, 80 and over, Chi-Square Distribution, business.industry, Reproducibility of Results, General Medicine, Middle Aged, medicine.disease, Prognosis, Confidence interval, Up-Regulation, Logistic Models, Atrial Flutter, England, Area Under Curve, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Chi-squared distribution, Biomarkers
Abstract

Objective: Serum cardiac troponins can be elevated in acute coronary syndromes (ACS) and other non-ACS conditions. We investigated the usefulness of a prediction score model comprising clinical variables to distinguish patients with ACS from other non-ACS conditions. Methods: Two independent, non-randomized observational cohorts (groups 1 and 2) were examined, comprising consecutive patients who were admitted to a university teaching hospital and found to have a raised serum troponin T level (>=0.01 [mu]g/l). The international definition was used to confirm acute myocardial infarction. Multivariate logistic regression identified clinical variables in the first cohort, which were used to construct a score model for distinguishing between ACS and non-ACS, and this score was re-evaluated in the second cohort. Results: Of the 313 patients in group 1, a score model was formulated using logarithm troponin T, ischaemic chest pain, ST depression and atrial fibrillation or flutter. Using a score of more than or equal to 1.5, sensitivity and specificity for predicting non-ACS were 0.81 and 0.84. The area under the curve was 0.900 (95% confidence interval 0.867-0.934). Sensitivity and specificity for predicting non-ACS among the 341 patients in group 2 using the same model and a score of more than or equal to 1.5 were 0.76 and 0.89, respectively, and the area under the curve was 0.918 (confidence interval 0.887-0.945). Conclusion: A prediction score model using simple clinical variables has been validated, and this can help clinicians in distinguishing patients with ACS from other non-ACS conditions.

Published
2010

16. An unusual cause of breathlessness in a young man

Author

Antony Leslie Innasimuthu, Rob S. Hornung, Rajiv Sankarnarayanan, and Gopala Krishna B. Rao

Subjects
Adult, Cardiomyopathy, Dilated, Male, education.field_of_study, Pediatrics, medicine.medical_specialty, business.industry, Incidence (epidemiology), Population, Amphetamine-Related Disorders, Cardiomyopathy, Dilated cardiomyopathy, Case Report, medicine.disease, Dyspnea, Heart failure, Anesthesia, Amphetamine abuse, medicine, Humans, Cardiology and Cardiovascular Medicine, education, Amphetamine, business, medicine.drug
Abstract

Amphetamine abuse is a common problem in the developed world. Cardiomyopathy secondary to amphetamine abuse is rare in the general population. The present report describes a 34-year-old man who presented with shortness of breath. Following further investigations, the cause of his breathlessness was determined to be amphetamine abuse. The incidence of amphetamine abuse and its cardiac sequelae are reviewed. The mechanism of amphetamine-induced dilated cardiomyopathy is analyzed, with further review of its complications and treatment.

Published
2009

24. Severe rheumatic mitral stenosis in a young caucasian man: A forgotten entity

Author

Prashanth Raju, Gopala Krishna B. Rao, Lindsay Morrison, and Robert S Hornung

Subjects
Pediatrics, medicine.medical_specialty, Heart disease, business.industry, Incidence (epidemiology), valvular heart disease, Rheumatic mitral stenosis, Electronic journal, Disease, medicine.disease, Pulmonary hypertension, medicine, Rheumatic fever, business
Abstract

Introduction: Rheumatic mitral stenosis is considered to be a disease of the past, especially in young population in developed countries. Case report: We came across a young 30-year-old male Caucasian presenting with severe rheumatic mitral stenosis associated with pulmonary hypertension in unusually short span of time. Conclusion: Our case illustrates that rheumatic heart disease although declining in incidence in the UK, may still present at a relatively young age. Consequently, we should remain vigilant and be aware of the presenting symptoms and signs of rheumatic fever.

Published
2011

27. Advanced studies in strip pair processing of Cartosat-1 data.

Author

Srivastava, Pradeep K., Srinivasan, T. P., Gupta, Amit, Singh, Sanjay, Nain, Jagjeet Singh, Prakash, Shilpa, Kartikeyan, B., and Gopala Krishna, B.

Subjects
ARTIFICIAL satellites, REMOTE sensing, REMOTE sensing equipment, PHOTOGRAMMETRY, THREE-dimensional imaging in astronomy
Abstract

With the launch of the Indian remote sensing satellite Cartosat-1, an along-track stereoscopic imaging mission of the Indian Space Research Organisation (ISRO), new possibilities for operational availability of high-resolution stereo-imagery from space for the remote sensing and cartography user communities have emerged. The high-resolution stereo data beamed from twin cameras on board the Cartosat-1 mission facilitates topographic mapping up to 1:25 000 scale. The primary advantage of the Cartosat-1 mission is seen in the generation of digital elevation models (DEMs) and the production of ortho-images in an operational set-up. This also facilitates 3D terrain visualisation for very large tracts of land. Stereo Strip Triangulation (SST) is a software system developed and perfected at the Space Applications Centre of ISRO for operational generation of secondary control and appropriate DEMs for subsequent use in the generation of ortho-images. This system has been in use for almost 2 years at the National Remote Sensing Agency in Hyderabad, India, and has generated a wealth of data for use in topographic mapping. An initiative to generate a database of seamless, homogeneous DEMs and associated ortho-image tiles at country level has been undertaken by ISRO. This data-set has been named CartoDEM. The Cartosat-1 data processing team has completed the design and testing of software for the generation of the CartoDEM. This software system has undergone detailed evaluation and currently is in the final stage of development of the operational procedures required to make maximum use of the capabilities of the Cartosat-1 sensors. A data dissemination software system is currently under development. As part of the large-scale evaluation exercises to finalise the specifications of CartoDEM, it is established that with the 2·5 m ground resolution, a base-to-height ratio of 0·62 and with capability to register conjugate points in the stereopair to sub-pixel level, DEMs can be generated at 0·3 arc second intervals, with a height accuracy of 3 to 4 m, over tracts of undulating land mass up to 15 000 km2 with the use of 10 to 20 ground control points. The Cartosat-1 data processing and evaluation team regularly monitors the radiometric quality of images. As part of the radiometric characterisation of sensors, the team computed point spread functions (PSFs) for the two cameras of Cartosat-1. Special filters based on the PSFs then work to improve the radiometric quality of the images. Initial results from these exercises show good promise in image restoration based on PSFs for Cartosat-1. This paper presents a summary of activities and exercises related to (i) Stereo Strip Triangulation, (ii) CartoDEM, (iii) image quality improvement using the PSF-based image restoration and (iv) block adjustment exercises using a COTS software package. Also reported are the results of post-launch experiments, study and evaluation of DEMs vis-à-vis ortho-images from Cartosat-1. [ABSTRACT FROM AUTHOR]

Published
2008
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