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297 results on '"Gorgi, Y."'

18. Hepatitis C Virus Antibodies in Dialysis Patients in Tunisia: A Single Center Study

Author

Sassi F, Gorgi Y, Ayed K, Abdallah T, Lamouchi A, and Maiz H

Subjects
Hemodialysis, Hepatitis C, Tunisia., Medicine
Abstract

Fifty-eight patients on maintenance hemodialysis in a dialysis unit at Tunis, Tunisia were tested for anti-hepatitis C virus (anti-HCV) antibodies by second generation ELISA test, and for HCV-RNA by nested reverse transcriptase polymerase chain reaction (RT-PCR) of 5′ non-coding region. Specificity of the antibodies was confirmed by immunoblot test. HCV genotype was defined using INNO-LIPA test. Twenty-seven out of 58 patients (46.5%) were reactive by ELISA. Transaminase levels were assessed over a six-month period and showed normal average values. Fourteen of the 27 anti-HCV positive patients (51%) were positive by RT-PCR. Type 1b HCV genotype was the most prevalent, seen in all the dialysis patients and one patient in addition, was co-infected with genotype 4. There was a significant correlation between the duration on dialysis (over five years) and the prevalence of anti-HCV-positive patients (P< 0.005) while no correlation existed between the number of blood transfusions and the presence of anti-HCV antibodies. The present study illustrates the high prevalence of HCV infection among Tunisian dialysis patients (51%) and indicates that the spread may be nosocomial rather than transfusion-related.

Published
2000

34. Preliminary results of the project A.I.D.A. (Auto Immunity: Diagnosis Assisted by computer)

Author

Benammar Elgaaied, A, BRUNO, Salvatore, CASCIO, Donato, CIACCIO, Maria Cristina, CIPOLLA, Marco, FAUCI, Alessandro, MORGANTE, Rossella, Gorgi, Y, Marrakchi Triki, R, Ben Ahmed, M, Louzir, H, Yalaoui, S, Sfar, I, Issaoui, Y, Abidi, A, Ammar, M, Bedhiafi, W, Ben Fraj, O, Bouhaha, R, Hamdi, K, Koudhi, S, Neili, B, Gati, A, Lucchese, M, Catanzaro, M, Barbara, V, Brusca, I, Fregapane, M, Amato, G, Friscia, G, Trai, N, Souayeh, T, Haouami, Y, Rekik, R, Bouokez, H, Fauci, F, Taormina, V, Vasile Simone, M, RASO, Giuseppe, Benammar Elgaaied, A, Bruno, S, Cascio, D, Ciaccio M.C, Cipolla, M, Fauci, A, Morgante, R, Gorgi, Y, Marrakchi Triki, R, Ben Ahmed, M, Louzir, H, Yalaoui, S, Sfar, I, Issaoui, Y, Abidi, A, Ammar, M, Bedhiafi, W, Ben Fraj, O, Bouhaha, R, Hamdi, K, Koudhi, S, Neili, B, Gati, A, Lucchese, M, Catanzaro, M, Barbara, V, Brusca, I, Fregapane, M, Amato, G, Friscia, G, Trai, N, Souayeh, T, Haouami, Y, Rekik, R, Bouokez, H, Fauci, F, Taormina, V, Vasile Simone, M, and Raso, G

Subjects
Autoimmunity, ImmunoFluorescence, Database, Gold Standard, CAD, Patterns, Accuracy, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract

In this paper, are presented the preliminary results of the A.I.D.A. (Auto Immunity: Diagnosis Assisted by computer) project which is developed in the frame of the cross-border cooperation Italy-Tunisia. According to the main objectives of this project, a database of interpreted Indirect ImmunoFluorescence (IIF) images on HEp 2 cells is being collected thanks to the contribution of Italian and Tunisian experts involved in routine diagnosis of autoimmune diseases. Through exchanging images and double reporting; a Gold Standard database, containing around 1000 double reported IIF images with different patterns including negative tests, has been settled. This Gold Standard database has been used for optimization of a computing solution (CADComputer Aided Detection) and for assessment of its added value in order to be used along with an immunologist as a second reader in detection of auto antibodies for autoimmune disease diagnosis. From the preliminary results obtained, the CAD appeared more powerful than junior immunologists used as second readers and may significantly improve their efficacy.

Published
2014

35. Allograft renal rejection and chemokine polymorphism

Author

Gorgi, Y., Sfar, I., Jendoubi-Ayed, S., Makhlouf, M., Rhomdhane, T. B., Bardi, R., Aouadi, H., Abdallah, T. B., Ezzedine Abderrahim, and Ayed, K.

Subjects
lcsh:R, lcsh:Medicine
Abstract

Chemokines play a major role in the process by which leukocytes are recruited from the bloodstream into the sites of inflammation. Genes for the chemokine receptors CCR5, CCR2 and MCP-1 are characterized by functional polymorphisms implicated in transplant rejection. To investigate this association, we analyzed polymorphisms of CCR5-∆32, CCR5-59029-A/G, CCR2-V64I and MCP-1 G/A (-2518) in 173 renal transplant recipients and 169 healthy blood donors. The patients were classified in two groups: Group-1 (G-1) included 33 HLA-identical recipients and Group-2 (G-2) included 140 (one or more) mismatched graft recipients. Forty-two patients had developed acute rejection episodes (ARs): seven in G-1 and 35 in G-2. Thirteen G-2 patients developed chronic allograft dysfunction (CAD). The genotypic and allelic frequencies of all polymorphisms studied did not reveal significant differences between patients and controls and among G-1 and G-2 recipients. However, a significant risk of acute renal transplant rejection was found in G-1 patients who possessed the CCR2-64I allele (odds ratio 0.24, 95% confidence inter-val [CI], 0.05-1.06; P = 0.035). There was no significant association of this polymorphism and CAD. In conclusion, the observed association of CCR2-64I with AR should be added to the spectrum of immunogenetic factors known to be involved in allograft renal loss.

Published
2011

37. Anti-factor H autoantibodies in Tunisian aHUS patients

Author

Sellami, M. Kallel, primary, Ayadi, Imen, additional, Jalouli, M., additional, Mahmouda, D. Hadj, additional, Jlajla, H., additional, Kheder, R., additional, Zerzeri, Y., additional, Sfar, I., additional, Laadhar, L., additional, Achour, L., additional, Mahfoud, A., additional, Moussa, F. Ben, additional, Gorgi, Y., additional, Gargeh, T., additional, and Sellami, M. Kallel, additional

Published
2017
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47. The involvement of HLA -DRB1FNx01, DQA1FNx01, DQB1FNx01 and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians

Author

Ayed K, Gorgi Y, Ayed-Jendoubi S, and Bardi R

Subjects
analysis, lcsh:R, Complement C4a, lcsh:Medicine, HLA-DR Antigens, immune system diseases, blood, Case-Control Studies, HLA-DQ Antigens, Lupus Er, Humans, Female, skin and connective tissue diseases, Immunoglobulin Allotypes
Abstract

BACKGROUND: Genetic susceptibility to systemic lupus erythematosus (SLE) varies among populations. Few data exist on associations of HLA class II and class III alleles of the major histocompatibility complex (MHC) and susceptibility to SLE in Tunisians. PATIENTS AND METHODS: We compared HLA-DRB1FNx01, DQA1, DQB1FNx01 and C4 allotypes in 62 Tunisian SLE patients and 100 matched controls. We also assessed the association of specific alleles with distinct autoantibody profiles in SLE patients. RESULTS: HLA-DRB1FNx010301, -DRB1FNx011501 and C4AQO alleles were increased in the SLE patients, while the frequencies of HLA-DRB1FNx0104 and DQB1FNx0103 were decreased. HLA-DQA1FNx010102 and DQA1FNx010501 were significantly increased in the SLE patients. HLA-DQB1FNx010201 and DQB1FNx010602 were more frequent in the SLE patients. C4AFNx01QO and C4BFNx01QO were increased in frequency in the SLE patients compared to the controls, but only C4A null was significantly increased. Eleven of 17 SLE patients with the C4 null allele were HLA-DRB1FNx010301 positive. Three of 16 SLE patients with HLA-DRB1FNx011501 were associated with HLA-DQB1FNx010501 rather than DQB1FNx010602, as has been reported in European SLE patients. CONCLUSIONS: The MHC class II alleles (DRB1, DQA1, DQB1) and C4 null associations noted in other ethnic groups are also found in Tunisians, suggesting shared susceptibility factors across ethnic lines in predisposition to SLE. In contrast to other ethnic groups, MHC class II alleles are not associated with the presence of specific autoantibodies in Tunisian SLE patients.

Published
2004

48. La pancréatite chronique auto-immune : à propos de 3 cas

Author

Mouelhi, L., primary, Ayadi, S., additional, Sfar, I., additional, Houissa, F., additional, Eljeri, K., additional, Khedher, S., additional, Said, Y., additional, Salem, M., additional, Debbeche, R., additional, Gorgi, Y., additional, and Najjar, T., additional

Published
2016
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