1. Expansion of T-Cell Receptor zeta(dim) Effector T Cells in Acute Coronary Syndromes
- Author
-
M. Banfi, Claudia Monaco, Claire L. Gorman, Andrew P. Cope, Anna Chiara Vermi, Luca A. Ferri, Angelo A. Manfredi, Cosmo Godino, Chiara Foglieni, Attilio Maseri, Flavio Airoldi, Enrico Ammirati, Domenico Cianflone, Ammirati, E, Vermi, Ac, Cianflone, Domenico, Banfi, M, Foglieni, C, Godino, C, Airoldi, F, Ferri, La, Gorman, Cl, Manfredi, ANGELO ANDREA M. A., Maseri, A, Cope, Ap, and Monaco, C.
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,Lymphocyte ,T cell ,Receptors, Antigen, T-Cell ,CD8-Positive T-Lymphocytes ,Angina Pectoris ,Interleukin 21 ,Immune system ,Antigen ,T-Lymphocyte Subsets ,Medicine ,Humans ,Acute Coronary Syndrome ,Aged ,Inflammation ,biology ,business.industry ,C-reactive protein ,T lymphocyte ,Middle Aged ,Atherosclerosis ,Flow Cytometry ,Killer Cells, Natural ,medicine.anatomical_structure ,C-Reactive Protein ,Case-Control Studies ,Immunology ,biology.protein ,Female ,Cardiology and Cardiovascular Medicine ,business ,CD8 - Abstract
Objective— The T-cell receptor zeta (TCRζ)-chain is a master sensor and regulator of lymphocyte responses. Loss of TCRζ-chain expression has been documented during infectious and inflammatory diseases and defines a population of effector T cells (TCRζ dim T cells) that migrate to inflamed tissues. We assessed the expression and functional correlates of circulating TCRζ dim T cells in coronary artery disease. Methods and Results— We examined the expression of TCRζ-chain by flow cytometry in 140 subjects. Increased peripheral blood CD4 + TCRζ dim T cells were found in patients with acute coronary syndromes (ACS, n=66; median 5.3%, interquartile 2.6 to 9.1% of total CD4 + T cells; P dim cells were also more represented within CD8 + T cell, NK, and CD4 + CD28 null T cell subsets in ACS compared to CSA and controls. Finally, CD4 + and CD8 + TCRζ dim T cells isolated from ACS displayed an enhanced transendothelial migratory capacity. Conclusions— TCRζ dim T cells, an effector T-cell subset with transendothelial migratory ability, are increased in ACS, and may be implicated in coronary instability.
- Published
- 2008