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6. Obstructive sleep apnea and cognitive functioning in the older general population: The moderating effect of age, sex, ApoE4, and obesity

Author

Marchi, N., Berger, M., Solelhac, G., Bayon, V., Haba‐Rubio, J., Legault, J., Thompson, C., Gosselin, N., Vollenweider, P., Marques‐Vidal, P., von Gunten, A., Strippoli, M., Preisig, M., Draganski, B., and Heinzer, R.

Abstract

Research on the relationship between obstructive sleep apnea and cognitive functioning has yielded conflicting results, particularly in the older population, and moderators of this association have rarely been studied. Here we investigated the cross-sectional association between obstructive sleep apnea and cognitive functioning as well as the moderating effect of age, sex, apolipoprotein E4, and obesity on this association among community-dwelling older people. We analysed data from 496 participants (71.4 ± 4.4 years; 45.6% men) of the HypnoLaus study who underwent polysomnography and a battery of neuropsychological tests. The sample was categorised as no-to-mild obstructive sleep apnea (apnea-hypopnea index 0-14.9/h; reference), moderate obstructive sleep apnea (apnea-hypopnea index 15.0-29.9/h), or severe obstructive sleep apnea (apnea-hypopnea index ≥30/h). Regression and moderation analyses were performed with adjustment for confounders. Apolipoprotein E4 and obesity moderated the association between severe obstructive sleep apnea and processing speed, whereas no moderating effects were found for age and sex. In apolipoprotein E4 carriers only, severe obstructive sleep apnea was associated with lower performance in Stroop condition 1 (B = 3.13, p = 0.024). In obese participants only, severe obstructive sleep apnea was associated with lower performance in Stroop condition 1 (B = 3.02, p = 0.025) and Stroop condition 2 (B = 3.30, p = 0.034). Severe obstructive sleep apnea was also associated with lower executive function in the whole sample according to Stroop condition 3 (B = 3.44, p = 0.020) and Stroop interference score (B = 0.24, p = 0.006). Our findings support associations of severe obstructive sleep apnea (but not moderate obstructive sleep apnea) with lower performance in processing speed and executive function in the older general population. Apolipoprotein E4 and obesity appear to be vulnerability factors that strengthen the association between severe obstructive sleep apnea and lower performance in processing speed.

Published
2023

7. Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea

Author

Villar, G. M., Daneault, V., Martineau-Dussault, M. E., Baril, A. A., Gagnon, K., Lafond, C., Gilbert, D., Thompson, C., Marchi, N. A., Lina, J. M., Montplaisir, J., Carrier, J., Gosselin, N., Andre, C., Villar, G. M., Daneault, V., Martineau-Dussault, M. E., Baril, A. A., Gagnon, K., Lafond, C., Gilbert, D., Thompson, C., Marchi, N. A., Lina, J. M., Montplaisir, J., Carrier, J., Gosselin, N., and Andre, C.

Abstract

Introduction: Obstructive sleep apnea (OSA) is increasingly recognized as a risk factor for cognitive decline, and has been associated with structural brain alterations in regions relevant to memory processes and Alzheimer’s disease. However, it is unclear whether OSA is associated with disrupted functional connectivity (FC) patterns between these regions in late middle-aged and older populations. Thus, we characterized the associations between OSA severity and resting-state FC between the default mode network (DMN) and medial temporal lobe (MTL) regions. Second, we explored whether significant FC changes differed depending on cognitive status and were associated with cognitive performance. Methods: Ninety-four participants [24 women, 65.7 ± 6.9 years old, 41% with Mild Cognitive Impairment (MCI)] underwent a polysomnography, a comprehensive neuropsychological assessment and a resting-state functional magnetic resonance imaging (MRI). General linear models were conducted between OSA severity markers (i.e., the apnea-hypopnea, oxygen desaturation and microarousal indices) and FC values between DMN and MTL regions using CONN toolbox. Partial correlations were then performed between OSA-related FC patterns and (i) OSA severity markers in subgroups stratified by cognitive status (i.e., cognitively unimpaired versus MCI) and (ii) cognitive scores in the whole sample. All analyzes were controlled for age, sex and education, and considered significant at a p < 0.05 threshold corrected for false discovery rate. Results: In the whole sample, a higher apnea-hypopnea index was significantly associated with lower FC between (i) the medial prefrontal cortex and bilateral hippocampi, and (ii) the left hippocampus and both the posterior cingulate cortex and precuneus. FC patterns were not associated with the oxygen desaturation index, or micro-arousal index. When stratifying the sample according to cognitive status, all associations remained significant in cognitively unimpaired i

Published
2023

8. Sleep architecture in idiopathic hypersomnia

Author

Deshaies-Rugama, A.-S., primary, Blais, H., additional, Sekerovic, Z., additional, Massicotte, M., additional, Carrier, J., additional, Thompson, C., additional, Nigam, M., additional, Desautels, A., additional, Montplaisir, J., additional, and Gosselin, N., additional

Published
2022
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32. Sleep spindles are resilient to extensive white matter deterioration

Author

Sanchez, E., primary, Arbour, C., additional, El-Khatib, H., additional, Marcotte, K., additional, Blais, H., additional, Baril, A.-A., additional, Bedetti, C., additional, Descoteaux, M., additional, Lina, J.-M., additional, Gilbert, D., additional, Carrier, J., additional, and Gosselin, N., additional

Published
2019
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49. NEUROPSYCHOLOGICAL EVALUATION OF CONCUSSION: COMPARISON OF THE MCGILL 'ON-FIELD' EVALUATION TO THE NHL TEST BATTERY

Author

Leelere, S.L., Lassonde, M., Giroux, F., Gosselin, N., and Johnston, K.M.

Subjects
National Hockey League -- Management -- Evaluation, McGill University -- Evaluation -- Management, Management, Evaluation, Medical examination, Health aspects, Company business management, College sports -- Health aspects, Medical tests -- Evaluation -- Health aspects, College athletes -- Medical examination -- Health aspects, Concussion -- Health aspects, Sports injuries -- Health aspects, Brain -- Concussion
Abstract

15

Published
2001

50. Cognitive impairment in obstructive sleep apnea

Author

Gagnon, K., primary, Baril, A.-A., additional, Gagnon, J.-F., additional, Fortin, M., additional, Décary, A., additional, Lafond, C., additional, Desautels, A., additional, Montplaisir, J., additional, and Gosselin, N., additional

Published
2014
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