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2,505 results on '"Gotoh M"'

9. Electron-Beam-Induced Decomposition of SiO2 Overlay on Si in STM Nanolithography

Author

Iwasaki, H., Ito, T., Gotoh, M., Nan, L., Sudoh, K., Beig, R., editor, Englert, B. -G., editor, Frisch, U., editor, Hänggi, P., editor, Hepp, K., editor, Hillebrandt, W., editor, Imboden, D., editor, Jaffe, R. L., editor, Lipowsky, R., editor, v. Löhneysen, H., editor, Ojima, I., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Wess, J., editor, Zittartz, J., editor, Watanabe, Yoshio, editor, Salviati, Giancarlo, editor, Heun, Stefan, editor, and Yamamoto, Naoki, editor

Published
2002
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11. Impact of Board Certification and Adherence to Clinical Practice Guidelines for Liver Cancer on Post-Hepatectomy Mortality Rate in Japan: A Questionnaire Survey of Departments Registered with the National Clinical Database

Author

Arita, J., primary, Yamamoto, H., additional, Kokudo, T., additional, Hasegawa, K., additional, Miyata, H., additional, Toh, Y., additional, Gotoh, M., additional, Kokudo, N., additional, Kakeji, Y., additional, and Seto, Y., additional

Published
2022
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36. Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome-epigenome correlation

Author

Arai, E., Miura, F., Totoki, Y., Yamashita, S., Tian, Y., Gotoh, M., Ojima, H., Nakagawa, H., Takahashi, Y., Nakamura, H., Hama, N., Kato, M., Kimura, Hiroshi, Suzuki, Y., Ito, T., Shibata, T., and Kanai, Y.

Subjects
0301 basic medicine, Cancer Research, Bisulfite sequencing, personal differentially methylated region, DNA Methylation, Biology, Epigenesis, Genetic, 03 medical and health sciences, Gene expression, Genetics, International Human Epigenome Consortium, Humans, Epigenetics, Gene, Sequence Analysis, RNA, Genetic Variation, High-Throughput Nucleotide Sequencing, Epigenome, CpG Islands, Hepatocytes/*metabolism, 030104 developmental biology, Differentially methylated regions, CpG site, DNA methylation, Hepatocytes, postbisulfite adaptor tagging, Transcription Initiation Site
Abstract

Aim: The aim of this study was to reveal the epigenome landscape of human normal hepatocytes. Materials & methods: Cells purified from partial hepatectomy specimens of Japanese patients were subjected to whole-genome bisulfite sequencing using postbisulfite adaptor tagging, chromatin immunoprecipitation sequencing, RNA sequencing and whole-genome sequencing. Results: CHG and CHH methylations were inversely associated with gene expression. Histone modification profiles of personal differentially methylated regions (pDMRs) differed considerably among samples. pDMRs were observed around the transcription start sites of genes whose expression is reportedly regulated by CpG methylation. pDMRs were frequently observed in the vicinity of single-nucleotide variations and insertions/deletions. Conclusion: Genetic variations may induce epigenetic variations, generating individual differences in the phenotypes of normal hepatocytes through variations in expression.

Published
2018

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