1. Non-lymphoma hematological malignancies in systemic lupus erythematosus.
- Author
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Lu, Mary, Bernatsky, Sasha, Ramsey-Goldman, Rosalind, Petri, Michelle, Manzi, Susan, Urowitz, Murray B, Gladman, Dafna, Fortin, Paul R, Ginzler, Ellen M, Yelin, Edward, Bae, Sang-Cheol, Wallace, Daniel J, Jacobsen, Soren, Dooley, Mary Anne, Peschken, Christine A, Alarcón, Graciela S, Nived, Ola, Gottesman, Lena, Criswell, Lindsey A, Sturfelt, Gunnar, Dreyer, Lene, Lee, Jennifer L, and Clarke, Ann E
- Subjects
Humans ,Hematologic Neoplasms ,Lupus Erythematosus ,Systemic ,Incidence ,Cohort Studies ,Adult ,Aged ,Middle Aged ,Female ,Male ,Pediatric Cancer ,Clinical Research ,Rare Diseases ,Lymphoma ,Hematology ,Lupus ,Cancer ,Orphan Drug ,Pediatric ,Childhood Leukemia ,2.1 Biological and endogenous factors ,Aetiology ,Systemic lupus erythematosus ,Malignancy ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
ObjectiveTo describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE).MethodsA large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers.ResultsIn 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks).ConclusionsIn this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.
- Published
- 2013