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7 results on '"Goubert, Virginie"'

2. The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients

Author

López‐Janeiro, Álvaro, primary, Villalba‐Esparza, María, additional, Brizzi, María Emilia, additional, Jiménez‐Sánchez, Daniel, additional, Ruz‐Caracuel, Ignacio, additional, Kadioglu, Ece, additional, Masetto, Ivan, additional, Goubert, Virginie, additional, Garcia‐Ros, David, additional, Melero, Ignacio, additional, Peláez‐García, Alberto, additional, Hardisson, David, additional, and de Andrea, Carlos E, additional

Published
2022
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3. Proteomic analysis of low-grade, early-stage endometrialcarcinoma reveals new dysregulated pathways associated with cell death and cell signaling

Author

Instituto de Salud Carlos III, European Commission, López-Janeiro, Álvaro [0000-0002-5744-3115], Ruz-Caracuel, Ignacio [0000-0002-2298-4683], Ramón-Patino, Jorge L. [0000-0002-7308-823X], Ríos, Vivian de los [0000-0001-5582-6879], Villalba Esparza, María [0000-0002-9183-0610], Berjón, Alberto [0000-0002-3467-106X], Kadioglu, Ece [0000-0001-8679-8030], Heredia-Soto, Victoria [0000-0002-0704-7958], Barderas, Rodrigo [0000-0003-3539-7469], Casal, J. Ignacio [0000-0003-1085-2840], De Andrea, Carlos E. [0000-0002-7628-8050], Mendiola, Marta [0000-0002-2463-1304], Peláez-García, Alberto [0000-0002-5401-3216], Hardisson, David [0000-0002-2183-3699], López-Janeiro, Álvaro, Ruz-Caracuel, Ignacio, Ramón-Patino, Jorge L., Ríos, Vivian de los, Villalba Esparza, María, Berjón, Alberto, Yébenes, Laura, Hernández, Alicia, Masetto, Ivan, Kadioglu, Ece, Goubert, Virginie, Heredia-Soto, Victoria, Barderas, Rodrigo, Casal, J. Ignacio, De Andrea, Carlos E., Redondo, Andrés, Mendiola, Marta, Peláez-García, Alberto, Hardisson, David, Instituto de Salud Carlos III, European Commission, López-Janeiro, Álvaro [0000-0002-5744-3115], Ruz-Caracuel, Ignacio [0000-0002-2298-4683], Ramón-Patino, Jorge L. [0000-0002-7308-823X], Ríos, Vivian de los [0000-0001-5582-6879], Villalba Esparza, María [0000-0002-9183-0610], Berjón, Alberto [0000-0002-3467-106X], Kadioglu, Ece [0000-0001-8679-8030], Heredia-Soto, Victoria [0000-0002-0704-7958], Barderas, Rodrigo [0000-0003-3539-7469], Casal, J. Ignacio [0000-0003-1085-2840], De Andrea, Carlos E. [0000-0002-7628-8050], Mendiola, Marta [0000-0002-2463-1304], Peláez-García, Alberto [0000-0002-5401-3216], Hardisson, David [0000-0002-2183-3699], López-Janeiro, Álvaro, Ruz-Caracuel, Ignacio, Ramón-Patino, Jorge L., Ríos, Vivian de los, Villalba Esparza, María, Berjón, Alberto, Yébenes, Laura, Hernández, Alicia, Masetto, Ivan, Kadioglu, Ece, Goubert, Virginie, Heredia-Soto, Victoria, Barderas, Rodrigo, Casal, J. Ignacio, De Andrea, Carlos E., Redondo, Andrés, Mendiola, Marta, Peláez-García, Alberto, and Hardisson, David

Abstract

Low-grade, early-stage endometrial carcinoma (EC) is the most frequent malignant tumor of the uterine corpus. However, the molecular alterations that underlie these tumors are far from being fully understood. The purpose of this study is to describe dysregulated molecular pathways from EC patients. Sixteen samples of tumor tissue and paired healthy controls were collected and both were subjected to mass spectrometry (MS)/MS proteomic analysis. Gene ontology and pathway analysis was performed to discover dysregulated pathways and/or proteins using different databases and bioinformatic tools. Dysregulated pathways were cross-validated in an independent external cohort. Cell signaling, immune response, and cell death-associated pathways were robustly identified. The SLIT/ROBO signaling pathway demonstrated dysregulation at the proteomic and transcriptomic level. Necroptosis and ferroptosis were cell death-associated processes aberrantly regulated, in addition to apoptosis. Immune response-associated pathways showed a dominance of innate immune responses. Tumor immune infiltrates measured by immunofluorescence demonstrated diverse lymphoid and myeloid populations. Our results suggest a role of SLIT/ROBO, necroptosis, and ferroptosis, as well as a prominent role of innate immune response in low-grade, early-stage EC. These results could guide future research in this group of tumors

Published
2021

5. Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling

Author

López-Janeiro, Álvaro, primary, Ruz-Caracuel, Ignacio, additional, Ramón-Patino, Jorge L., additional, De Los Ríos, Vivian, additional, Villalba Esparza, María, additional, Berjón, Alberto, additional, Yébenes, Laura, additional, Hernández, Alicia, additional, Masetto, Ivan, additional, Kadioglu, Ece, additional, Goubert, Virginie, additional, Heredia-Soto, Victoria, additional, Barderas, Rodrigo, additional, Casal, José Ignacio, additional, de Andrea, Carlos E., additional, Redondo, Andrés, additional, Mendiola, Marta, additional, Peláez-García, Alberto, additional, and Hardisson, David, additional

Published
2021
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7. The von Economo neurons in fronto-insular and anterior cingulate cortex

Author

Allman, John M., Tetreault, Nicole A., Hakeem, Atiya Y., Manaye, Kebreten F., Semendeferi, Katerina, Erwin, Joseph M., Park, Soyoung, Goubert, Virginie, and Hof, Patrick R.

Subjects
Neurons, Primates, Animals, Humans, Cell Count, Growth and Development, Biological Evolution, Gyrus Cinguli, Models, Biological, Article
Abstract

The von Economo neurons (VENs) are large bipolar neurons located in the frontoinsular cortex (FI) and limbic anterior (LA) area in great apes and humans but not in other primates. Our stereological counts of VENs in FI and LA show them to be more numerous in humans than in apes. In humans, small numbers of VENs appear the 36th week postconception, with numbers increasing during the first 8 months after birth. There are significantly more VENs in the right hemisphere in postnatal brains; this may be related to asymmetries in the autonomic nervous system. VENs are also present in elephants and whales and may be a specialization related to very large brain size. The large size and simple dendritic structure of these projection neurons suggest that they rapidly send basic information from FI and LA to other parts of the brain, while slower neighboring pyramids send more detailed information. Selective destruction of VENs in early stages of frontotemporal dementia (FTD) implies that they are involved in empathy, social awareness, and self-control, consistent with evidence from functional imaging.

Published
2011

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