183 results on '"Goudriaan, A.E."'
Search Results
2. Unity in diversity: A systematic review on the GHB using population
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Dijkstra, B.A.G., Beurmanjer, H., Goudriaan, A.E., Schellekens, A.F.A., and Joosten, E.A.G.
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- 2021
- Full Text
- View/download PDF
3. Biocueing and ambulatory biofeedback to enhance emotion regulation: A review of studies investigating non-psychiatric and psychiatric populations
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ter Harmsel, J.F., Noordzij, M.L., Goudriaan, A.E., Dekker, J.J.M., Swinkels, L.T.A., van der Pol, T.M., and Popma, A.
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- 2021
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4. The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users
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Kaag, A.M., Schulte, M.H.J., Jansen, J.M., van Wingen, G., Homberg, J., van den Brink, W., Wiers, R.W., Schmaal, L., Goudriaan, A.E., and Reneman, L.
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- 2018
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5. Goal-directed and habitual decision making under stress in gambling disorder: An fMRI study
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van Timmeren, T., Piray, P., Goudriaan, A.E., van Holst, R.J., Stress and self-regulation, and Leerstoel Ridder
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The development of addictive behaviors has been suggested to be related to a transition from goal-directed to habitual decision making. Stress is a factor known to prompt habitual behavior and to increase the risk for addiction and relapse. In the current study, we therefore used functional MRI to investigate the balance between goal-directed 'model-based' and habitual 'model-free' control systems and whether acute stress would differentially shift this balance in gambling disorder (GD) patients compared to healthy controls (HCs). Using a within-subject design, 22 patients with GD and 20 HCs underwent stress induction or a control condition before performing a multistep decision-making task during fMRI. Salivary cortisol levels showed that the stress induction was successful. Contrary to our hypothesis, GD patients did not show impaired goal-directed 'model-based' decision making, which remained similar to HCs after stress induction. Bayes factors provided three times more evidence against a difference between the groups or a group-by-stress interaction on the balance between model-based and model-free decision making. Similarly, no differences were found between groups and conditions on the neural estimates of model-based or model-free decision making. These results challenge the notion that GD is related to an increased reliance on habitual (or decreased goal-directed) control, even during stress.
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- 2023
6. Therapeutic effect of psilocybin in addiction: A systematic review
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Meer, P.B. van der, Fuentes, J.J., Kaptein, A.A., Schoones, J.W., Waal, M.M. de, Goudriaan, A.E., Kramers, C., Schellekens, A.F.A., Somers, M., Bossong, M.G., Batalla, A., Meer, P.B. van der, Fuentes, J.J., Kaptein, A.A., Schoones, J.W., Waal, M.M. de, Goudriaan, A.E., Kramers, C., Schellekens, A.F.A., Somers, M., Bossong, M.G., and Batalla, A.
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Item does not contain fulltext, Background: Psychedelic-assisted therapy [e.g., with lysergic acid diethylamide (LSD)] has shown promising results as treatment for substance use disorders (SUDs). Previous systematic reviews assessing the efficacy of psilocybin in SUDs only included clinical trials conducted in the last 25 years, but they may have missed clinical trials assessing the efficacy of psilocybin that were conducted before the 1980s, given much research has been done with psychedelics in the mid-20th century. In this systematic review, we specifically assessed the efficacy of psilocybin in patients with a SUD or non-substance-related disorder with no publication date restrictions in our search strategy. Methods: A systematic literature search was performed according to Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines from the earliest published manuscript up to September 2, 2022, in seven electronic databases, including clinical trials in patients with a SUD or non-substance-related disorder evaluating the efficacy of psilocybin. Results: A total of four studies (six articles, of which two articles were long-term follow-up results from the same trial) were included in this systematic review. Psilocybin-assisted therapy was administered to n = 151 patients in a dose ranging from 6 to 40 mg. Three studies focused on alcohol use disorder, and one study on tobacco use disorder. In a pilot study (n = 10), the percentage of heavy drinking days decreased significantly between baseline and weeks 5-12 (mean difference of 26.0, 95% CI = 8.7-43.2, p = 0.008). In another single-arm study (n = 31), 32% (10/31) became completely abstinent from alcohol (mean duration of follow-up 6 years). In a double-blind, placebo-controlled randomized controlled trial (RCT, n = 95), the percentage of heavy drinking days during the 32-week double-blind period was significantly lower for psilocybin compared to placebo (mean difference of 13.9, 95% CI = 3.0–24.7, p = 0.01). In a pil
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- 2023
7. Effects of 10 add-on HF-rTMS treatment sessions on alcohol use and craving among detoxified inpatients with alcohol use disorder: A randomized sham-controlled clinical trial
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Hoven, M., Schluter, R., Schellekens, A.F.A., Holst, R.J. van, Goudriaan, A.E., Hoven, M., Schluter, R., Schellekens, A.F.A., Holst, R.J. van, and Goudriaan, A.E.
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Contains fulltext : 253754.pdf (Publisher’s version ) (Open Access), Background and aims: Alcohol use disorder (AUD) is a chronic disorder with high relapse rates. There are currently few clinical trials of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) to reduce alcohol use among AUD patients, and results are mixed. The current study tested the effect of 10 add-on sessions of HF-rTMS over the right dorsolateral pre-frontal cortex (DLPFC) on alcohol use and craving. Design: Single-center, single blind sham-controlled parallel-group RCT (n = 80), with 3 and 6 months follow-up. Setting: Clinical treatment center in Amsterdam, the Netherlands. Participants: Eighty detoxified and abstinent AUD inpatients in clinical treatment (20 females, average age = 44.35 years). Intervention: Ten sessions of active or sham HF-rTMS (60 10 Hz trains of 5 sec at 110% motor threshold) over the right DLPFC on 10 consecutive work-days. Measurements: The primary outcome measure is the number of abstinent days over 6-month follow-up (FU). Secondary outcome measures are craving over 6-month FU (alcohol urge questionnaire and obsessive-compulsive drinking scale), time to first relapse over 6-month FU and grams of alcohol consumed over 6-month FU. Additional outcome measures: full abstinence over 6-month FU and treatment success over 12-month FU. Findings: HF-rTMS did not affect the number of abstinent days over 6 months FU [sham = 124 ± 65.9 days, active = 115 ± 69.8 days, difference: 9 days, 95% confidence interval (CI) = Poisson model: 0.578-3.547]. Moreover, HF-rTMS did not affect craving (AUQ/OCDS) (sham = 15.38/5.28, active = 17.48/4.75, differences = 2.1/-0.53, 95% CI mixed-effects model = -9.14 to 2.07/-1.44 to 2.40). Conclusions: There was no clear evidence that high-frequency repetitive transcranial magnetic stimulation over the right dorsolateral pre-frontal cortex treatment has a long-term positive effect on alcohol use or craving as add-on treatment for alcohol use disorder. High treatment response at 6-month follow-up could
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- 2023
8. Goal-directed and habitual decision making under stress in gambling disorder: An fMRI study
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Stress and self-regulation, Leerstoel Ridder, van Timmeren, T., Piray, P., Goudriaan, A.E., van Holst, R.J., Stress and self-regulation, Leerstoel Ridder, van Timmeren, T., Piray, P., Goudriaan, A.E., and van Holst, R.J.
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- 2023
9. Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder Striatal ups or downs?
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Stress and self-regulation, Leerstoel Ridder, Van Timmeren, T., Van Holst, R.J., Goudriaan, A.E., Stress and self-regulation, Leerstoel Ridder, Van Timmeren, T., Van Holst, R.J., and Goudriaan, A.E.
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- 2023
10. Cannabis dependence, cognitive control and attentional bias for cannabis words
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Cousijn, J., Watson, P., Koenders, L., Vingerhoets, W.A.M., Goudriaan, A.E., and Wiers, R.W.
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- 2013
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11. Alcohol Reduction to Reduce Relapse in Acute Alcoholic Pancreatitis—Missed Opportunities
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Sissingh, N.J., Umans, D.S., Goudriaan, A.E., Sijbom, M., Verdonk, R.C., Hooft, J.E. van, Dutch Pancreatitis Study Grp, Gastroenterology and Hepatology, Graduate School, Amsterdam Gastroenterology Endocrinology Metabolism, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, and APH - Digital Health
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medicine.medical_specialty ,Alcohol Drinking ,Pancreatitis, Alcoholic ,medicine.medical_treatment ,Psychological intervention ,Original Manuscript ,Motivational Interviewing ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Surveys and Questionnaires ,Psychoeducation ,Secondary Prevention ,Medicine ,Humans ,AcademicSubjects/MED00860 ,030212 general & internal medicine ,Netherlands ,Response rate (survey) ,First episode ,business.industry ,Primary care physician ,Social Support ,General Medicine ,medicine.disease ,Hospitals ,Patient Discharge ,Crisis Intervention ,Emergency medicine ,Pancreatitis ,030211 gastroenterology & hepatology ,Brief intervention ,business ,Psychosocial - Abstract
Aim Resuming drinking is a main contributant to recurrence in alcoholic pancreatitis. We assessed current clinical practice in the Netherlands regarding alcohol in managing patients with a first episode of acute alcoholic pancreatitis. Methods A survey was distributed to 35 hospitals affiliated with the Dutch Pancreatitis Study Group. We evaluated current support based on various components of brief interventions, the participation of psychosocial healthcare providers, the cooperation with the primary care physicians and the presence of a protocol and its implementation. Results The response rate was 100% (n = 35). Psychoeducation is the most frequently performed intervention in current support treatment (97% of hospitals). In 17% of hospitals, healthcare providers with a psychosocial background routinely participate in current support treatment; 37% of hospitals create an individual treatment plan in which goals regarding alcohol cessation are specified and only 46% of hospitals provide the primary care physician with specific discharge information; 31% of hospitals indicate that the treatment is uniformly performed within their division of Gastroenterology. Protocols are available in 3% of the hospitals surveyed. Opportunities to involve the patient’s social network were not given sufficient priority. Conclusion Among Dutch hospitals, there is no routine management strategy with regard to enhancing treatment for heavy alcohol use in alcoholic pancreatitis patients. There is a need to test a validated support program in randomized studies. Meanwhile, possible opportunities for effecting change are often missed.
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- 2021
12. Metacognition and the effect of incentive motivation in two compulsive disorders: gambling disorder and obsessive‐compulsive disorder
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Hoven, M., Boer, N.S. de, Goudriaan, A.E., Denys, D.A.J.P., Lebreton, M., Holst, R.J. van, Hoven, M., Boer, N.S. de, Goudriaan, A.E., Denys, D.A.J.P., Lebreton, M., and Holst, R.J. van
- Abstract
Contains fulltext : 253485.pdf (Publisher’s version ) (Open Access)
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- 2022
13. Effects of 10 add-on HF-rTMS treatment sessions on alcohol use and craving among detoxified inpatients with alcohol use disorder: A randomized sham-controlled clinical trial
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Hoven, M., Schluter, R., Schellekens, A.F.A., Holst, R.J. van, Goudriaan, A.E., Hoven, M., Schluter, R., Schellekens, A.F.A., Holst, R.J. van, and Goudriaan, A.E.
- Abstract
Contains fulltext : 253754.pdf (Publisher’s version ) (Open Access), Background and aims: Alcohol use disorder (AUD) is a chronic disorder with high relapse rates. There are currently few clinical trials of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) to reduce alcohol use among AUD patients, and results are mixed. The current study tested the effect of 10 add-on sessions of HF-rTMS over the right dorsolateral pre-frontal cortex (DLPFC) on alcohol use and craving. Design: Single-center, single blind sham-controlled parallel-group RCT (n = 80), with 3 and 6 months follow-up. Setting: Clinical treatment center in Amsterdam, the Netherlands. Participants: Eighty detoxified and abstinent AUD inpatients in clinical treatment (20 females, average age = 44.35 years). Intervention: Ten sessions of active or sham HF-rTMS (60 10 Hz trains of 5 sec at 110% motor threshold) over the right DLPFC on 10 consecutive work-days. Measurements: The primary outcome measure is the number of abstinent days over 6-month follow-up (FU). Secondary outcome measures are craving over 6-month FU (alcohol urge questionnaire and obsessive-compulsive drinking scale), time to first relapse over 6-month FU and grams of alcohol consumed over 6-month FU. Additional outcome measures: full abstinence over 6-month FU and treatment success over 12-month FU. Findings: HF-rTMS did not affect the number of abstinent days over 6 months FU [sham = 124 ± 65.9 days, active = 115 ± 69.8 days, difference: 9 days, 95% confidence interval (CI) = Poisson model: 0.578-3.547]. Moreover, HF-rTMS did not affect craving (AUQ/OCDS) (sham = 15.38/5.28, active = 17.48/4.75, differences = 2.1/-0.53, 95% CI mixed-effects model = -9.14 to 2.07/-1.44 to 2.40). Conclusions: There was no clear evidence that high-frequency repetitive transcranial magnetic stimulation over the right dorsolateral pre-frontal cortex treatment has a long-term positive effect on alcohol use or craving as add-on treatment for alcohol use disorder. High treatment response at 6-month follow-up could
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- 2022
14. Youth in transition: Study protocol of a prospective cohort study into the long-term course of addiction, mental health problems and social functioning in youth entering addiction treatment
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Moska, C., Goudriaan, A.E., Blanken, P., Mheen, H. van de, Spijkerman, R., Schellekens, A.F.A., Jonge, J.M. de, Bary, F., Vollebergh, W.A.M., Hendriks, V.M., Moska, C., Goudriaan, A.E., Blanken, P., Mheen, H. van de, Spijkerman, R., Schellekens, A.F.A., Jonge, J.M. de, Bary, F., Vollebergh, W.A.M., and Hendriks, V.M.
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Contains fulltext : 241718.pdf (Publisher’s version ) (Open Access), Background: Substance use disorders (SUDs) are prevalent in the general population, tend to follow a chronic course, are associated with many individual and social problems, and often have their onset in adolescence. However, the knowledge base from prospective population surveys and treatment-outcome studies on the course of SUD in adolescents is limited at best. The present study aims to fill this gap and focuses on a subgroup that is particularly at risk for chronicity: adolescents in addiction treatment. We will investigate the rate of persistent SUD and its predictors longitudinally from adolescence to young adulthood among youth with DSM-5 SUD from the start of their addiction treatment to 2 and 4 years following treatment-entry. In addition to SUD, we will investigate the course of comorbid mental disorders, social functioning, and quality of life and their association with SUD over time. Methods/design: In a naturalistic, multi-center prospective cohort design, we will include youths (n = 420), who consecutively enter addiction treatment at ten participating organizations in the Netherlands. Inclusion is prestratified by treatment organization, to ensure a nationally representative sample. Eligible youths are 16 to 22 years old and seek help for a primary DSM-5 cannabis, alcohol, cocaine or amphetamine use disorder. Assessments focus on lifetime and current substance use and SUD, non-SUD mental disorders, family history, life events, social functioning, treatment history, quality of life, chronic stress indicators (hair cortisol) and neuropsychological tests (computerized executive function tasks) and are conducted at baseline, end of treatment, and 2 and 4 years post-baseline. Baseline data and treatment data (type, intensity, duration) will be used to predict outcome - persistence of or desistance from SUD. Discussion: There are remarkably few prospective studies worldwide that investigated the course of SUD in adolescents in addiction treatment for longer
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- 2021
15. The effect of non-invasive brain stimulation on executive functioning in healthy controls: A systematic review and meta-analysis
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Boer, N.S. de, Schluter, R.S., Daams, J., Werf, Y.D. van der, Goudriaan, A.E., Holst, R.J. van, Boer, N.S. de, Schluter, R.S., Daams, J., Werf, Y.D. van der, Goudriaan, A.E., and Holst, R.J. van
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Item does not contain fulltext
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- 2021
16. Economic Evaluation of the SOS Training to Reduce Victimization in Dual Diagnosis Patients
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de Waal, M.M., Blankers, M., Lommerse, N.M., Kikkert, M.J., Dekker, J.J.M., Goudriaan, A.E., de Waal, M.M., Blankers, M., Lommerse, N.M., Kikkert, M.J., Dekker, J.J.M., and Goudriaan, A.E.
- Abstract
Objective: Economic evaluations of interventions for dual diagnosis patients are scarce. A recent randomized controlled trial has supported the effectiveness of the Self-wise, Otherwise, Streetwise (SOS) training to reduce victimization in dual diagnosis patients. The purpose of the current study was to analyze the cost-effectiveness and cost-utility of the SOS training as an add-on to care as usual (CAU). Methods: We performed an economic evaluation from a societal perspective alongside the SOS trial. Participants were 250 dual diagnosis patients recruited at three locations from a large urban psychiatric service in the Netherlands. The main outcomes were treatment response for victimization and quality-adjusted life years (QALYs). Both costs and effects were measured across a 14-month follow-up. Results: There was no significant difference between CAU + SOS and CAU in total costs (mean difference €4,859; 95% CI [−€4,795 to €14,513]) and QALY gains (mean difference 0.0012; 95% CI [−0.05 to 0.05]). Significantly more participants in CAU + SOS achieved treatment response for victimization compared to CAU (68% vs. 54%; mean difference 0.14; 95% CI [0.02 to 0.26]). The cost-effectiveness analysis indicated an 83% likelihood that CAU + SOS resulted in a higher treatment response rate for victimization at higher costs compared to CAU. The cost-utility analysis indicated that adding SOS-training to CAU is probably not cost-effective at conventional willingness-to-pay levels for QALYs. Conclusions: At a societal willingness-to-pay of €38,000 or more per extra treatment responder, adding SOS-training to usual care is probably more attractive than usual care alone with regard to cost-effectiveness. This is a considerable willingness to pay. However, the direct costs of offering the SOS training are expected to be minor. Our findings should be interpreted with caution due to the short follow-up period and absence of data on potential reductions in police and judicial costs ot
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- 2021
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17. Often overlooked and ignored, but do not underestimate its relevance: ADHD in addiction - addiction in ADHD
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Schellekens, A.F.A., Brink, W. van den, Kiefer, F., Goudriaan, A.E., Schellekens, A.F.A., Brink, W. van den, Kiefer, F., and Goudriaan, A.E.
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Contains fulltext : 221828.pdf (Publisher’s version ) (Open Access)
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- 2020
18. Alcohol- and drug-related public violence in Europe
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Amsterdam, J. van, Ramaekers, J.G., Verkes, R.J., Kuypers, K.P.C., Goudriaan, A.E., Brink, W. van den, Amsterdam, J. van, Ramaekers, J.G., Verkes, R.J., Kuypers, K.P.C., Goudriaan, A.E., and Brink, W. van den
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Item does not contain fulltext
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- 2020
19. A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study
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Yücel, M., Oldenhof, E., Ahmed, S.H., Belin, D., Billieux, J., Bowden-Jones, H., Carter, A., Chamberlain, S.R., Clark, L., Connor, J., Daglish, M., Dom, G., Dannon, P., Duka, T., Fernandez-Serrano, M.J., Field, M., Franken, I., Goldstein, R.Z., Gonzalez, R., Goudriaan, A.E., Grant, J.E., Gullo, M.J., Hester, R., Hodgins, D.C., Le Foll, B., Lee, R.S.C., Lingford-Hughes, A., Lorenzetti, V., Moeller, S.J., Munafò, M.R., Odlaug, B., Potenza, M.N., Segrave, R., Sjoerds, Z., Solowij, N., Brink, W., Holst, R.J., Voon, V., Wiers, R., Fontenelle, L.F., Verdejo-Garcia, A., Yücel, Murat [0000-0002-4705-452X], Ahmed, Serge H [0000-0002-1225-9234], Billieux, Joel [0000-0002-7388-6194], Carter, Adrian [0000-0002-3593-0772], Clark, Luke [0000-0003-1103-2422], Daglish, Mark [0000-0002-1787-4375], Goudriaan, Anna E [0000-0001-8670-9384], Grant, Jon E [0000-0001-7784-7021], Gullo, Matthew J [0000-0003-3657-5191], Hester, Robert [0000-0003-0982-8026], Hodgins, David C [0000-0003-2737-5200], Le Foll, Bernard [0000-0002-6406-4973], Lingford-Hughes, Anne [0000-0003-4512-3453], Moeller, Scott J [0000-0002-4449-0844], Munafò, Marcus R [0000-0002-4049-993X], Odlaug, Brian [0000-0001-5407-0686], Sjoerds, Zsuzsika [0000-0001-9467-3772], Solowij, Nadia [0000-0002-5222-5637], Wiers, Reinout [0000-0002-4312-9766], Verdejo-Garcia, Antonio [0000-0001-8874-9339], Apollo - University of Cambridge Repository, ANS - Compulsivity, Impulsivity & Attention, APH - Mental Health, Adult Psychiatry, APH - Digital Health, Ontwikkelingspsychologie (Psychologie, FMG), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Laboratory of Molecular Neuropsychiatry, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Bristol [Bristol], Department of Psychiatry [Amsterdam, The Netherlands], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Department of Neurology, and University of Toronto-Toronto Western Hospital
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ALCOHOL-DEPENDENT PATIENTS ,DISORDER ,cognition ,Delphi Technique ,assessment ,RELAPSE ,Brain and Behaviour ,Habits ,11 Medical and Health Sciences ,ComputingMilieux_MISCELLANEOUS ,reward ,habit ,National Institute of Mental Health (U.S.) ,Psychiatry ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,Neurosciences & comportement [H07] [Sciences sociales & comportementales, psychologie] ,Tobacco and Alcohol ,Substance Abuse ,17 Psychology and Cognitive Sciences ,Europe ,Inhibition, Psychological ,transdiagnostic ,HUMAN DRUG-ADDICTION ,Compulsive Behavior ,Physical and Mental Health ,Neurosciences & behavior [H07] [Social & behavioral sciences, psychology] ,Life Sciences & Biomedicine ,RESPONSE-INHIBITION ,IMPULSE CONTROL ,Asia ,Substance-Related Disorders ,Decision Making ,Addiction ,Reward ,RDoC ,Humans ,Learning ,SUBSTANCE USE ,Science & Technology ,Australia ,decision-making ,South America ,United States ,Behavior, Addictive ,North America ,COMPULSIVITY ,INCENTIVE-SENSITIZATION THEORY ,Human medicine ,decision‐making ,compulsions - Abstract
BackgroundThe US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. The RDoC framework comprises 39 functional constructs designed to be revised and refined, with the overall goal of improving diagnostic validity and treatments. This study aimed to reach a consensus among experts in the addiction field on the ‘primary’ RDoC constructs most relevant to substance and behavioural addictions.MethodsForty‐four addiction experts were recruited from Australia, Asia, Europe and the Americas. The Delphi technique was used to determine a consensus as to the degree of importance of each construct in understanding the essential dimensions underpinning addictive behaviours. Expert opinions were canvassed online over three rounds (97% completion rate), with each consecutive round offering feedback for experts to review their opinions.ResultsSeven constructs were endorsed by ≥ 80% of experts as ‘primary’ to the understanding of addictive behaviour: five from the Positive Valence System (reward valuation, expectancy, action selection, reward learning, habit); one from the Cognitive Control System (response selection/inhibition); and one expert‐initiated construct (compulsivity). These constructs were rated to be related differentially to stages of the addiction cycle, with some linked more closely to addiction onset and others more to chronicity. Experts agreed that these neuropsychological dimensions apply across a range of addictions.ConclusionsThe study offers a novel and neuropsychologically informed theoretical framework, as well as a cogent step forward to test transdiagnostic concepts in addiction research, with direct implications for assessment, diagnosis, staging of disorder, and treatment.
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- 2019
20. Alteration to hippocampal volume and shape confined to cannabis dependence: a multi-site study
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Chye, Y., Lorenzetti, Valentina, Suo, C., Batalla, A., Cousijn, J., Goudriaan, A.E., Yucel, Murat, Solowij, Nadia, Chye, Y., Lorenzetti, Valentina, Suo, C., Batalla, A., Cousijn, J., Goudriaan, A.E., Yucel, Murat, and Solowij, Nadia
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Contains fulltext : 204600.pdf (publisher's version ) (Closed access)
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- 2019
21. Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects
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Mackey, S., Allgaier, N., Chaarani, B., Spechler, P., Orr, C., Bunn, J., Allen, N.B., Alia-Klein, N., Batalla, A., Blaine, S., Brooks, S., Caparelli, E., Chye, Y.Y., Cousijn, J., Dagher, A., Desrivieres, S., Feldstein-Ewing, S., Foxe, J.J., Goldstein, R.Z., Goudriaan, A.E., Heitzeg, M.M., Hester, R., Hutchison, K.E., Korucuoglu, O., Li, C.S.R., London, E.D., Lorenzetti, V., Luijten, M., Martin-Santos, R., May, A., Momenan, R., Morales, A.M., Paulus, M.P., Pearlson, G., Rousseau, M.E., Salmeron, B.J., Schluter, R., Schmaal, L., Schumann, G., Sjoerds, Z., Stein, D.J., Stein, E.A., Sinha, R., Solowij, N., Tapert, S., Uhlmann, A., Veltman, D.J., Holst, R.J. van, Whittle, S., Wright, M.J., Yücel, M., Zhang, S., Yurgelun-Todd, D., Hibar, D.P., Jahanshad, N., Evans, A.C., Thompson, P.M., Glahn, D.C., Conrod, P., Garavan, H., Mackey, S., Allgaier, N., Chaarani, B., Spechler, P., Orr, C., Bunn, J., Allen, N.B., Alia-Klein, N., Batalla, A., Blaine, S., Brooks, S., Caparelli, E., Chye, Y.Y., Cousijn, J., Dagher, A., Desrivieres, S., Feldstein-Ewing, S., Foxe, J.J., Goldstein, R.Z., Goudriaan, A.E., Heitzeg, M.M., Hester, R., Hutchison, K.E., Korucuoglu, O., Li, C.S.R., London, E.D., Lorenzetti, V., Luijten, M., Martin-Santos, R., May, A., Momenan, R., Morales, A.M., Paulus, M.P., Pearlson, G., Rousseau, M.E., Salmeron, B.J., Schluter, R., Schmaal, L., Schumann, G., Sjoerds, Z., Stein, D.J., Stein, E.A., Sinha, R., Solowij, N., Tapert, S., Uhlmann, A., Veltman, D.J., Holst, R.J. van, Whittle, S., Wright, M.J., Yücel, M., Zhang, S., Yurgelun-Todd, D., Hibar, D.P., Jahanshad, N., Evans, A.C., Thompson, P.M., Glahn, D.C., Conrod, P., and Garavan, H.
- Abstract
Contains fulltext : 200963.pdf (publisher's version ) (Closed access), Objective: Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes. Method: Brain structure was examined in a mega-analysis of previously published data pooled from 23 laboratories, including 3,240 individuals, 2,140 of whom had substance dependence on one of five substances: alcohol, nicotine, cocaine, methamphetamine, or cannabis. Subcortical volume and cortical thickness in regions defined by FreeSurfer were compared with nondependent control subjects when all sampled substance categories were combined, as well as separately, while controlling for age, sex, imaging site, and total intracranial volume. Because of extensive associations with alcohol dependence, a secondary contrast was also performed for dependence on all substances except alcohol. An optimized split-half strategy was used to assess the reliability of the findings. Results: Lower volume or thickness was observed in many brain regions in individuals with substance dependence. The greatest effects were associated with alcohol use disorder. A set of affected regions related to dependence in general, regardless of the substance, included the insula and the medial orbitofrontal cortex. Furthermore, a support vector machine multivariate classification of regional brain volumes successfully classified individuals with substance dependence on alcohol or nicotine relative to nondependent contr
- Published
- 2019
22. Cortical surface morphology in long-term cannabis users: A multi-site MRI study
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Chye, Y., Suo, C., Lorenzetti, V., Batalla, A., Cousijn, J., Goudriaan, A.E., Martin-Santos, R., Whittle, S., Solowij, N., Yucel, M., Chye, Y., Suo, C., Lorenzetti, V., Batalla, A., Cousijn, J., Goudriaan, A.E., Martin-Santos, R., Whittle, S., Solowij, N., and Yucel, M.
- Abstract
Item does not contain fulltext, Cannabis exerts its psychoactive effect through cannabinoid receptors that are widely distributed across the cortical surface of the human brain. It is suggested that cannabis use may contribute to structural alterations across the cortical surface. In a large, multisite dataset of 120 controls and 141 cannabis users, we examined whether differences in key characteristics of the cortical surface - including cortical thickness, surface area, and gyrification index were related to cannabis use characteristics, including (i) cannabis use vs. non-use, (ii) cannabis dependence vs. non-dependence vs. non-use, and (iii) early adolescent vs. late adolescent onset of cannabis use vs. non-use. Our results revealed that cortical morphology was not associated with cannabis use, dependence, or onset age. The lack of effect of regular cannabis use, including problematic use, on cortical structure in our study is contrary to previous evidence of cortical morphological alterations (particularly in relation to cannabis dependence and cannabis onset age) in cannabis users. Careful reevaluation of the evidence on cannabis-related harm will be necessary to address concerns surrounding the long-term effects of cannabis use and inform policies in a changing cannabis regulation climate.
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- 2019
23. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead
- Author
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Ekhtiari, H. (Hamed), Tavakoli, H. (Hosna), Addolorato, G. (Giovanni), Baeken, C. (Chris), Bonci, A. (Antonello), Campanella, S. (Salvatore), Castelo-Branco, L. (Luis), Challet-Bouju, G. (Gaëlle), Clark, V.P., Claus, E. (Eric), Dannon, P.N. (Pinhas N.), Del Felice, A. (Alessandra), den Uyl, T. (Tess), Diana, M. (Marco), di Giannantonio, M. (Massimo), Fedota, J.R. (John R.), Fitzgerald, P. (Paul), Gallimberti, L. (Luigi), Grall-Bronnec, M. (Marie), Herremans, S.C. (Sarah C.), Herrmann, M.J. (Martin J.), Jamil, A. (Asif), Khedr, E. (Eman), Kouimtsidis, C. (Christos), Kozak, K. (Karolina), Krupitsky, E. (Evgeny), Lamm, C. (Claus), Lechner, W.V. (William V.), Madeo, G. (Graziella), Malmir, N. (Nastaran), Martinotti, G. (Giovanni), McDonald, W.M. (William M.), Montemitro, C. (Chiara), Nakamura-Palacios, E.M. (Ester M.), Nasehi, M. (Mohammad), Noël, X. (Xavier), Nosratabadi, M. (Masoud), Paulus, M. (Martin), Pettorruso, M. (Mauro), Pradhan, B. (Basant), Praharaj, S.K. (Samir K.), Rafferty, H. (Haley), Sahlem, G. (Gregory), Salmeron, B.J. (Betty jo), Sauvaget, A. (Anne), Schluter, R.S. (Renée S.), Sergiou, C.S. (Carmen), Shahbabaie, A. (Alireza), Sheffer, C. (Christine), Spagnolo, P.A. (Primavera A.), Steele, V.R. (Vaughn R.), Yuan, T.-F. (Ti-fei), Dongen, J.D.M. (Josanne) van, Van Waes, V. (Vincent), Venkatasubramanian, G. (Ganesan), Verdejo-García, A. (Antonio), Verveer, I. (Ilse), Welsh, J.W. (Justine W.), Wesley, M.J. (Michael J.), Witkiewitz, K. (Katie), Yavari, F. (Fateme), Zarrindast, M.-R. (Mohammad-Reza), Zawertailo, L. (Laurie), Zhang, X. (Xiaochu), Cha, Y.-H. (Yoon-Hee), George, T.P. (Tony P.), Frohlich, F. (Flavio), Goudriaan, A.E. (Anna), Fecteau, S. (Shirley), Daughters, S.B. (Stacey B.), Stein, E.A. (Elliot A.), Fregni, F. (Felipe), Nitsche, M.A. (Michael A.), Zangen, A. (Abraham), Bikson, M. (Marom), Hanlon, C.A. (Colleen A.), Ekhtiari, H. (Hamed), Tavakoli, H. (Hosna), Addolorato, G. (Giovanni), Baeken, C. (Chris), Bonci, A. (Antonello), Campanella, S. (Salvatore), Castelo-Branco, L. (Luis), Challet-Bouju, G. (Gaëlle), Clark, V.P., Claus, E. (Eric), Dannon, P.N. (Pinhas N.), Del Felice, A. (Alessandra), den Uyl, T. (Tess), Diana, M. (Marco), di Giannantonio, M. (Massimo), Fedota, J.R. (John R.), Fitzgerald, P. (Paul), Gallimberti, L. (Luigi), Grall-Bronnec, M. (Marie), Herremans, S.C. (Sarah C.), Herrmann, M.J. (Martin J.), Jamil, A. (Asif), Khedr, E. (Eman), Kouimtsidis, C. (Christos), Kozak, K. (Karolina), Krupitsky, E. (Evgeny), Lamm, C. (Claus), Lechner, W.V. (William V.), Madeo, G. (Graziella), Malmir, N. (Nastaran), Martinotti, G. (Giovanni), McDonald, W.M. (William M.), Montemitro, C. (Chiara), Nakamura-Palacios, E.M. (Ester M.), Nasehi, M. (Mohammad), Noël, X. (Xavier), Nosratabadi, M. (Masoud), Paulus, M. (Martin), Pettorruso, M. (Mauro), Pradhan, B. (Basant), Praharaj, S.K. (Samir K.), Rafferty, H. (Haley), Sahlem, G. (Gregory), Salmeron, B.J. (Betty jo), Sauvaget, A. (Anne), Schluter, R.S. (Renée S.), Sergiou, C.S. (Carmen), Shahbabaie, A. (Alireza), Sheffer, C. (Christine), Spagnolo, P.A. (Primavera A.), Steele, V.R. (Vaughn R.), Yuan, T.-F. (Ti-fei), Dongen, J.D.M. (Josanne) van, Van Waes, V. (Vincent), Venkatasubramanian, G. (Ganesan), Verdejo-García, A. (Antonio), Verveer, I. (Ilse), Welsh, J.W. (Justine W.), Wesley, M.J. (Michael J.), Witkiewitz, K. (Katie), Yavari, F. (Fateme), Zarrindast, M.-R. (Mohammad-Reza), Zawertailo, L. (Laurie), Zhang, X. (Xiaochu), Cha, Y.-H. (Yoon-Hee), George, T.P. (Tony P.), Frohlich, F. (Flavio), Goudriaan, A.E. (Anna), Fecteau, S. (Shirley), Daughters, S.B. (Stacey B.), Stein, E.A. (Elliot A.), Fregni, F. (Felipe), Nitsche, M.A. (Michael A.), Zangen, A. (Abraham), Bikson, M. (Marom), and Hanlon, C.A. (Colleen A.)
- Abstract
There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.
- Published
- 2019
- Full Text
- View/download PDF
24. A qualitative approach in understanding illness perception and treatment needs in patients with gamma hydroxybutyrate use disorder
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Beurmanjer, H., Asperslag, E.M., Oliemeulen, E.A.P., Goudriaan, A.E., Jong, C.A.J. de, Schellekens, A.F.A., Dijkstra, B.A.G., Beurmanjer, H., Asperslag, E.M., Oliemeulen, E.A.P., Goudriaan, A.E., Jong, C.A.J. de, Schellekens, A.F.A., and Dijkstra, B.A.G.
- Abstract
Item does not contain fulltext, Background: The party drug gamma hydroxybutyrate (GHB) is highly addictive. GHB use disorder (GUD) has poor treatment outcome, with relapse rates over 60% within 3 months after detoxification. In order to get a better understanding of the limited treatment success, we explored GUD patients' illness perceptions and treatment needs. Methods: In a qualitative cross-sectional observational study, using a semi-structured interview based on the works of Kleinmann, illness perceptions were explored among treatment seeking GUD patients (n = 20). The analysis was based on the principles of Grounded Theory by the 2 interviewers and an independent researcher. Results: GUD patients had mainly positive views toward GHB. GHB was perceived as strongly rewarding and perceived as the solution to psychosocial problems, rather than the cause. After repeated readmissions, GUD patients perceived themselves as addicted to GHB and GHB use as more problematic. They reported a need for personalized treatment goals, which were mainly aimed toward dealing with psychiatric symptoms and social reintegration. Conclusion: GUD shares many characteristics with other substance use disorders, in line with gradual development from positive reinforcement in early-stage GUD to negative reinforcement in later stages of more compulsive GHB use. Future studies should investigate whether personalization of treatment goals, such as social reintegration, lead to better treatment outcomes.
- Published
- 2019
25. Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease
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Smeding, H.M.M., Goudriaan, A.E., Foncke, E.M.J., Schuurman, P.R., Speelman, J.D., and Schmand, B.
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Compulsive gambling -- Development and progression ,Parkinson's disease -- Care and treatment ,Neural stimulation -- Complications and side effects ,Health ,Psychology and mental health - Published
- 2007
26. Verslaving en comorbide psychiatrische stoornissen
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Goudriaan, A.E., Schellekens, A.F.A., Dom, G., Spinhoven, P., Bockting, C., Ruhe, E., Spijker, J., Spinhoven, P., Bockting, C., Ruhe, E., and Spijker, J.
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Experimental Psychopathology and Treatment ,Psychology ,Human medicine - Abstract
Item does not contain fulltext
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- 2018
27. Verslaving en comorbide psychiatrische stoornissen
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Spinhoven, P., Bockting, C., Ruhe, E., Spijker, J., Goudriaan, A.E., Schellekens, A.F.A., Dom, G., Spinhoven, P., Bockting, C., Ruhe, E., Spijker, J., Goudriaan, A.E., Schellekens, A.F.A., and Dom, G.
- Abstract
Item does not contain fulltext
- Published
- 2018
28. A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study
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Yücel, M. (Murat), Oldenhof, E. (Erin), Ahmed, S.H. (Serge H.), Belin, D. (David), Billieux, J. (Joel), Bowden-Jones, H. (Henrietta), Carter, A. (Adrian), Chamberlain, S.R. (Samuel R.), Clark, L. (Luke), Connor, J. (Jason), Daglish, M. (Mark), Dom, G. (Geert), Dannon, P. (Pinhas), Duka, T. (Theodora), Fernandez-Serrano, M.J. (Maria Jose), Field, M. (Matt), Franken, I.H.A. (Ingmar), Goldstein, R.Z. (Rita), Gonzalez, R. (Raul), Goudriaan, A.E. (Anna), Grant, J.E. (Jon E.), Gullo, M.J. (Matthew J.), Hester, R. (Rob), Hodgins, D.C. (David C.), Le Foll, B. (Bernard), Lee, R.S.C. (Rico S. C.), Lingford-Hughes, A. (Anne), Lorenzetti, V. (Valentina), Moeller, S.J. (Scott J.), Munafò, M.R. (Marcus), Odlaug, B. (Brian), Potenza, M.N. (Marc N.), Segrave, R. (Rebecca), Sjoerds, Z. (Zsuzsika), Solowij, N. (Nadia), Brink, W. (Wim) van den, Holst, R.J. (Ruth) van, Voon, V. (Valerie), Wiers, R.W. (Reinout), Fontenelle, L.F. (Leonardo F.), Verdejo-Garcia, A. (Antonio), Yücel, M. (Murat), Oldenhof, E. (Erin), Ahmed, S.H. (Serge H.), Belin, D. (David), Billieux, J. (Joel), Bowden-Jones, H. (Henrietta), Carter, A. (Adrian), Chamberlain, S.R. (Samuel R.), Clark, L. (Luke), Connor, J. (Jason), Daglish, M. (Mark), Dom, G. (Geert), Dannon, P. (Pinhas), Duka, T. (Theodora), Fernandez-Serrano, M.J. (Maria Jose), Field, M. (Matt), Franken, I.H.A. (Ingmar), Goldstein, R.Z. (Rita), Gonzalez, R. (Raul), Goudriaan, A.E. (Anna), Grant, J.E. (Jon E.), Gullo, M.J. (Matthew J.), Hester, R. (Rob), Hodgins, D.C. (David C.), Le Foll, B. (Bernard), Lee, R.S.C. (Rico S. C.), Lingford-Hughes, A. (Anne), Lorenzetti, V. (Valentina), Moeller, S.J. (Scott J.), Munafò, M.R. (Marcus), Odlaug, B. (Brian), Potenza, M.N. (Marc N.), Segrave, R. (Rebecca), Sjoerds, Z. (Zsuzsika), Solowij, N. (Nadia), Brink, W. (Wim) van den, Holst, R.J. (Ruth) van, Voon, V. (Valerie), Wiers, R.W. (Reinout), Fontenelle, L.F. (Leonardo F.), and Verdejo-Garcia, A. (Antonio)
- Abstract
Background: The US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. The RDoC framework comprises 39 functional constructs designed to be revised and refined, with the overall goal of improving diagnostic validity and treatments. This study aimed to reach a consensus among experts in the addiction field on the ‘primary’ RDoC constructs most relevant to substance and behavioural addictions. Methods: Forty-four addiction experts were recruited from Australia, Asia, Europe and the Americas. The Delphi technique was used to determine a consensus as to the degree of importance of each construct in understanding the essential dimensions underpinning addictive behaviours. Expert opinions were canvassed online over three rounds (97% completion rate), with each consecutive round offering feedback for experts to review their opinions. Results: Seven constructs were endorsed by ≥ 80% of experts as ‘primary’ to the understanding of addictive behaviour: five from the Positive Valence System (reward valuation, expectancy, action selection, reward learning, habit); one from the Cognitive Control System (response selection/inhibition); and one expert-initiated construct (compulsivity). These constructs were rated to be related differentially to stages of the addiction cycle, with some linked more closely to addiction onset and others more to chronicity. Experts agreed that these neuropsychological dimensions apply across a range of addictions. Conclusions: The study offers a novel and neuropsychologically informed theoretical framework, as well as a cogent step forward to test transdiagnostic concepts in addiction research, with direct implications for assessment, diagnosis, staging of disorder, and treatment.
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- 2018
- Full Text
- View/download PDF
29. Connectivity networks in gambling disorder: A resting-state fMRI study
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Timmeren, T. van, Zhutovsky, P., Holst, R.J. van, Goudriaan, A.E., Timmeren, T. van, Zhutovsky, P., Holst, R.J. van, and Goudriaan, A.E.
- Abstract
Contains fulltext : 216292.pdf (Publisher’s version ) (Open Access), Gambling disorder (GD) is characterized by an inability to stop or control gambling behaviour and is often accompanied by gambling-related cognitive distortions. Task-based functional Magnetic Resonance Imaging (fMRI) studies have revealed abnormal responses within the prefrontal and insular cortex, and mesolimbic reward regions. Studies examining resting-state functional connectivity in GD, although limited in number, have so far applied seed-based analysis approaches which revealed altered brain functioning. Here, we applied data-driven Independent Components Analysis to resting-state multi-echo fMRI data. Networks of interest were selected by spatially correlating them to independently derived network templates. Using dual regression, we compared connectivity strength between 20 GD patients and 20 healthy controls within 4 well-known networks (the ventral attention, limbic, frontoparietal control, and default mode network) and an additional basal ganglia component. Compared to controls, GD patients showed increased integration of the right middle insula within the ventral attention network, an area suggested to play an important role in addiction-related drive. Moreover, our findings indicate that gambling-related cognitive distortions - a hallmark of GD - were positively related to stronger integration of the amygdala, medial prefrontal cortex and insula within various resting-state networks.
- Published
- 2018
30. White matter integrity between left basal ganglia and left prefrontal cortex is compromised in gambling disorder
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Timmeren, T. van, Jansen, J.M., Caan, M.W.A., Goudriaan, A.E., Holst, R.J. van, Klinische Psychologie (Psychologie, FMG), Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Graduate School, Radiology and Nuclear Medicine, APH - Mental Health, Adult Psychiatry, APH - Digital Health, ACS - Diabetes & metabolism, ACS - Microcirculation, and ACS - Atherosclerosis & ischemic syndromes
- Subjects
All institutes and research themes of the Radboud University Medical Center ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] - Abstract
Pathological gambling (PG) is a behavioral addiction characterized by an inability to stop gambling despite the negative consequences, which may be mediated by cognitive flexibility deficits. Indeed, impaired cognitive flexibility has previously been linked to PG and also to reduced integrity of white matter connections between the basal ganglia and the prefrontal cortex. It remains unclear, however, how white matter integrity problems relate to cognitive inflexibility seen in PG. We used a cognitive switch paradigm during functional magnetic resonance imaging in pathological gamblers (PGs; n = 26) and healthy controls (HCs; n = 26). Cognitive flexibility performance was measured behaviorally by accuracy and reaction time on the switch task, while brain activity was measured in terms of blood oxygen level-dependent responses. We also used diffusion tensor imaging on a subset of data (PGs = 21; HCs = 21) in combination with tract-based spatial statistics and probabilistic fiber tracking to assess white matter integrity between the basal ganglia and the dorsolateral prefrontal cortex. Although there were no significant group differences in either task performance, related neural activity or tract-based spatial statistics, PGs did show decreased white matter integrity between the left basal ganglia and prefrontal cortex. Our results complement and expand similar findings from a previous study in alcohol-dependent patients. Although we found no association between white matter integrity and task performance here, decreased white matter connections may contribute to a diminished ability to recruit prefrontal networks needed for regulating behavior in PG. Hence, our findings could resonate an underlying risk factor for PG, and we speculate that these findings may extend to addiction in general.
- Published
- 2017
31. Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users
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Schulte, M.H.J., Kaag, A.M., Wiers, R.W.H.J., Schmaal, L., Brink, W. van den, Reneman, L., Homberg, J.R., Wingen, G.A. van, Goudriaan, A.E., Schulte, M.H.J., Kaag, A.M., Wiers, R.W.H.J., Schmaal, L., Brink, W. van den, Reneman, L., Homberg, J.R., Wingen, G.A. van, and Goudriaan, A.E.
- Abstract
Contains fulltext : 177182.pdf (publisher's version ) (Open Access), Glutamate and GABA play an important role in substance dependence. However, it remains unclear whether this holds true for different substance use disorders and how this is related to risk-related traits such as impulsivity. We, therefore, compared Glx (as a proxy measure for glutamate) and GABA concentrations in the dorsal anterior cingulate cortex (dACC) of 48 male cigarette smokers, 61 male smoking polysubstance users, and 90 male healthy controls, and investigated the relationship with self-reported impulsivity and substance use. Glx and GABA concentrations were measured using proton Magnetic Resonance Spectroscopy. Impulsivity, smoking, alcohol and cocaine use severity and cannabis use were measured using self-report instruments. Results indicate a trend towards group differences in Glx. Post-hoc analyses showed a difference between smokers and healthy controls (p=0.04) and a trend towards higher concentrations in smoking polysubstance users and healthy controls (p=0.09), but no differences between smokers and smoking polysubstance users. dACC GABA concentrations were not significantly different between groups. Smoking polysubstance users were more impulsive than smokers, and both groups were more impulsive than controls. No significant associations were observed between dACC neurotransmitter concentrations and impulsivity and level and severity of smoking, alcohol or cocaine use or the presence of cannabis use. The results indicate that differences in dACC Glx are unrelated to type and level of substance use. No final conclusion can be drawn on the lack of GABA differences due to assessment difficulties. The relationship between dACC neurotransmitter concentrations and cognitive impairments other than self-reported impulsivity should be further investigated.
- Published
- 2017
32. Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms
- Author
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Chye, Y., Solowij, N., Ganella, E.P., Suo, C., Yucel, M., Batalla, A., Cousijn, J., Goudriaan, A.E., Martin-Santos, R., Whittle, S., Bartholomeusz, C.F., Lorenzetti, V., Chye, Y., Solowij, N., Ganella, E.P., Suo, C., Yucel, M., Batalla, A., Cousijn, J., Goudriaan, A.E., Martin-Santos, R., Whittle, S., Bartholomeusz, C.F., and Lorenzetti, V.
- Abstract
Item does not contain fulltext, Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confer risk for earlier onset of cannabis (CB) use and greater use in later life. The OFC sulcogyral pattern may therefore be a stable trait marker in understanding individual differences in substance-use vulnerability and associated affective disturbances in users. In a large multisite cross-sectional study, we compared OFC pattern type distribution between 128 healthy controls (HC) and 146 CB users. Within users (n=140), we explored the association between OFC pattern type and CB use level, and subsequently if level of CB use informed by OFC pattern type may mediate disturbances in affective tone, as indexed by depressive symptoms. While OFC pattern distribution did not distinguish between HC and CB groups, it informed greater lifetime use within users. Specifically, CB users with pattern Type III in the right OFC tended to use more CB over their lifetime, than did CB users with pattern Type I or II. Greater lifetime CB use was subsequently associated with higher depressive symptoms, such that it mediated an indirect association between right OFC pattern Type III and higher depressive symptoms. The present study provides evidence for neurobiological differences, specifically sulcogyral pattern of the OFC, to modulate level of CB use, which may subsequently influence the expression of depressive symptoms.
- Published
- 2017
33. Genetic imaging consortium for addiction medicine: From neuroimaging to genes
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Mackey, S., Kan, K.-J., Chaarani, B., Alia-Klein, N., Batalla, A., Brooks, S., Cousijn, J., Dagher, D., de Ruiter, M., Desrivieres, S., Feldstein Ewing, S.W., Goldstein, R.Z., Goudriaan, A.E., Heitzeg, M.M., Hutchison, K., Li, C.S.R., London, E.D., Lorenzetti, V., Luijten, M., Martin-Santos, R., Morales, A.M., Paulus, M.P., Paus, T., Pearlson, G., Schluter, R., Momenan, R., Schmaal, L., Schumann, G., Sinha, R., Sjoerds, Z., Stein, D.J., Stein, E.A., Solowij, N., Tapert, S., Uhlmann, A., Veltman, D., van Holst, R., Walter, H., Wright, M.J., Yucel, M., Yurgelun-Todd, D., Hibar, D.P., Jahanshad, N., Thompson, P.M., Glahn, D.C., Garavan, H., Conrod, P., Ekhtiari, H., Paulus, M., and Ontwikkelingspsychologie (Psychologie, FMG)
- Abstract
Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction. The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.
- Published
- 2016
34. Reaching out towards cannabis: approach-bias in heavy cannabis users predicts changes in cannabis use
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Cousijn, J., Goudriaan, A.E., Wiers, R.W., Adult Psychiatry, Amsterdam Neuroscience, Ontwikkelingspsychologie (Psychologie, FMG), Faculteit der Geneeskunde, and ANS - Amsterdam Neuroscience
- Subjects
cannabis ,Adult ,Male ,Marijuana Abuse ,Adolescent ,cannabis use disorder ,Approach avoidance task ,Young Adult ,approach-bias ,Avoidance Learning ,Reaction Time ,Humans ,Attention ,Netherlands ,Motivation ,craving ,Smoking ,Research Reports ,dependence ,Behavior, Addictive ,Diagnostic and Statistical Manual of Mental Disorders ,Cross-Sectional Studies ,Disease Progression ,Female ,Cues ,Epidemiologic Methods ,Photic Stimulation ,Psychomotor Performance - Abstract
Aims Repeated drug exposure can lead to an approach-bias, i.e. the relatively automatically triggered tendencies to approach rather that avoid drug-related stimuli. Our main aim was to study this approach-bias in heavy cannabis users with the newly developed cannabis Approach Avoidance Task (cannabis-AAT) and to investigate the predictive relationship between an approach-bias for cannabis-related materials and levels of cannabis use, craving, and the course of cannabis use. Design, settings and participants Cross-sectional assessment and six-month follow-up in 32 heavy cannabis users and 39 non-using controls. Measurements Approach and avoidance action-tendencies towards cannabis and neutral images were assessed with the cannabis AAT. During the AAT, participants pulled or pushed a joystick in response to image orientation. To generate additional sense of approach or avoidance, pulling the joystick increased picture size while pushing decreased it. Craving was measured pre- and post-test with the multi-factorial Marijuana Craving Questionnaire (MCQ). Cannabis use frequencies and levels of dependence were measured at baseline and after a six-month follow-up. Findings Heavy cannabis users demonstrated an approach-bias for cannabis images, as compared to controls. The approach-bias predicted changes in cannabis use at six-month follow-up. The pre-test MCQ emotionality and expectancy factor were associated negatively with the approach-bias. No effects were found on levels of cannabis dependence. Conclusions Heavy cannabis users with a strong approach-bias for cannabis are more likely to increase their cannabis use. This approach-bias could be used as a predictor of the course of cannabis use to identify individuals at risk from increasing cannabis use.
- Published
- 2011
35. A high working memory load preceding alcohol cue exposure, reduces the desire for alcohol in non-treatment seeking problem drinkers
- Author
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Kaag, A.M., primary, Pattij, T., additional, De Vries, T.J., additional, Goudriaan, A.E., additional, and Wiers, R.W., additional
- Published
- 2017
- Full Text
- View/download PDF
36. An fMRI study on the effect of cue reactivity on striatal reward anticipation in alcohol dependent patients
- Author
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Van Timmeren, T., primary, Van Holst, R.J., additional, Van den Brink, W., additional, and Goudriaan, A.E., additional
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- 2017
- Full Text
- View/download PDF
37. Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls
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Jansen, J.M., van Holst, R.J., van den Brink, W., Veltman, D.J., Caan, M.W.A., Goudriaan, A.E., Anatomy and neurosciences, Psychiatry, and NCA - Neurobiology of mental health
- Published
- 2015
38. New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity
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Fineberg, N.A., Chamberlain, S.R., Goudriaan, A.E., Stein, D.J., Vanderschuren, L.J.M.J., Gillan, C.M., Shekar, S., Gorwood, P., Voon, V., Morein-Zamir, S., Denys, D.A.J.P., Sahakian, B.J., Moeller, F.G., Robbins, T.W., Potenza, M.N., Emotion and Cognition, Dep of Animals in Science and Society, ASS E&C1, and Netherlands Institute for Neuroscience (NIN)
- Subjects
Substance-Related Disorders ,media_common.quotation_subject ,Dysfunctional family ,Impulsivity ,Article ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Taverne ,medicine ,Addictive ,Animals ,Humans ,media_common ,Behavior ,Addiction ,Neuropsychology ,Cognition ,Prognosis ,030227 psychiatry ,Behavior, Addictive ,Psychiatry and Mental health ,International (English) ,Compulsive behavior ,Impulsive Behavior ,Compulsive Behavior ,Cognitive Science ,Neurology (clinical) ,medicine.symptom ,Psychology ,Neurocognitive ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.
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- 2014
39. Relationship between working-memory network function and substance use: a 3-year longitudinal fMRI study in heavy cannabis users and controls
- Author
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Cousijn, J., Vingerhoets, W.A.M., Koenders, L., de Haan, L., van den Brink, W., Wiers, R.W., Goudriaan, A.E., Ontwikkelingspsychologie (Psychologie, FMG), and Faculteit der Geneeskunde
- Abstract
Deficient executive functions play an important role in the development of addiction. Working-memory may therefore be a powerful predictor of the course of drug use, but chronic substance use may also impair working-memory. The aim of this 3-year longitudinal neuro-imaging study was to investigate the relationship between substance use (e.g. alcohol, cannabis, nicotine, illegal psychotropic drugs) and working-memory network function over time in heavy cannabis users and controls. Forty-nine participants performed an n-back working-memory task at baseline and at 3-year follow-up. At follow-up, there were 22 current heavy cannabis users, 4 abstinent heavy cannabis users and 23 non-cannabis-using controls. Tensor-independent component analysis (Tensor-ICA) was used to investigate individual differences in working-memory network functionality over time. Within the group of cannabis users, cannabis-related problems remained stable, whereas alcohol-related problems, nicotine dependence and illegal psychotropic substance use increased over time. At both measurements, behavioral performance and network functionality during the n-back task did not differ between heavy cannabis users and controls. Although n-back accuracy improved, working-memory network function remained stable over time. Within the group of cannabis users, working-memory network functionality was not associated with substance use. These results suggest that sustained moderate to heavy levels of cannabis, nicotine, alcohol and illegal psychotropic substance use do not change working-memory network functionality. Moreover, baseline network functionality did not predict cannabis use and related problems three years later, warranting longitudinal studies in more chronic or dependent cannabis users.
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- 2014
40. Working-memory network function in heavy cannabis users predicts changes in cannabis use: A prospective fMRI study
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Cousijn, J., Wiers, R.W., Ridderinkhof, K.R., Van den Brink, W., Veltman, D.J., and Goudriaan, A.E.
- Abstract
Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal of the current functional magnetic resonance imaging study was to assess the predictive power of working-memory network function for future cannabis use and cannabis-related problem severity in heavy cannabis users. Tensor independent component analysis was used to investigate differences in working-memory network function between 32 heavy cannabis users and 41 nonusing controls during an N-back working-memory task. In addition, associations were examined between working-memory network function and cannabis use and problem severity at baseline and at 6-month follow-up. Behavioral performance and working-memory network function did not significantly differ between heavy cannabis users and controls. However, among heavy cannabis users, individual differences in working-memory network response had an independent effect on change in weekly cannabis use 6 months later (ΔR2 = 0.11, P = 0.006, f2 = 0.37) beyond baseline cannabis use (ΔR2 = 0.41) and a behavioral measure of approach bias (ΔR2 = 0.18): a stronger network response during the N-back task was related to an increase in weekly cannabis use. These findings imply that heavy cannabis users requiring greater effort to accurately complete an N-back working-memory task have a higher probability of escalating cannabis use. Working-memory network function may be a biomarker for the prediction of course and treatment outcome in cannabis users.
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- 2014
41. Neural responses associated with cue-reactivity in frequent cannabis users
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Cousijn, J., Goudriaan, A.E., Ridderinkhof, K.R., van den Brink, W., Veltman, D.J., Wiers, R.W., Anatomy and neurosciences, Psychiatry, NCA - Neurobiology of mental health, Ontwikkelingspsychologie (Psychologie, FMG), and Faculteit der Geneeskunde
- Abstract
Cue-reactivity reflects enhanced motivational processing underlying continued substance use and relapse in substance use disorders. Substance use disorders are associated with greater cue-reactivity in orbitofrontal cortex, anterior cingulate cortex, striatum, ventral tegmental area and amygdala. Here we examine whether this also holds for frequent cannabis users. Using functional magnetic resonance imaging (fMRI), neural responses to neutral and cannabis-related cues were compared between frequent cannabis users (n = 31), sporadic cannabis users (n = 20) and cannabis-naive controls (n = 21). In addition, fMRI findings were correlated with the level of cannabis use, problem severity and craving. In frequent users compared with sporadic users and controls, cannabis images engendered higher activation than control images in the ventral tegmental area. Activation of the orbitofrontal cortex, anterior cingulate cortex and striatum was only higher in a subgroup of frequent users with high compared with low-problem severity. Activity in the right putamen and right dorsolateral prefrontal cortex correlated negatively with subjective craving in frequent users. Activity was not correlated with level of cannabis use. These findings indicate that cannabis cues activate areas associated with addiction pathology in frequent cannabis users compared with sporadic users and controls. However, among frequent users, cue-reactivity seems to be primarily associated with problem severity, not with amount of cannabis use. These findings imply neural cue-reactivity as a tool in assessing problem severity of cannabis use.
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- 2013
42. Implicit associations and explicit expectancies toward cannabis in heavy cannabis users and controls
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Beraha, E.M., Cousijn, J., Hermanides, E., Goudriaan, A.E., Wiers, R.W., and Ontwikkelingspsychologie (Psychologie, FMG)
- Subjects
psychological phenomena and processes - Abstract
Cognitive biases, including implicit memory associations are thought to play an important role in the development of addictive behaviors. The aim of the present study was to investigate implicit affective memory associations in heavy cannabis users. Implicit positive-arousal, sedation, and negative associations toward cannabis were measured with three Single Category Implicit Association Tests (SC-IAT's) and compared between 59 heavy cannabis users and 89 controls. Moreover, we investigated the relationship between these implicit affective associations and explicit expectancies, subjective craving, cannabis use, and cannabis related problems. Results show that heavy cannabis users had stronger implicit positive-arousal associations but weaker implicit negative associations toward cannabis compared to controls. Moreover, heavy cannabis users had stronger sedation but weaker negative explicit expectancies toward cannabis compared to controls. Within heavy cannabis users, more cannabis use was associated with stronger implicit negative associations whereas more cannabis use related problems was associated with stronger explicit negative expectancies, decreasing the overall difference on negative associations between cannabis users and controls. No other associations were observed between implicit associations, explicit expectancies, measures of cannabis use, cannabis use related problems, or subjective craving. These findings indicate that, in contrast to other substances of abuse like alcohol and tobacco, the relationship between implicit associations and cannabis use appears to be weak in heavy cannabis users.
- Published
- 2013
43. Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study
- Author
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Cousijn, J., Wiers, R.W., Ridderinkhof, K.R., van den Brink, W., Veltman, D.J., Porrino, L.J., Goudriaan, A.E., Ontwikkelingspsychologie (Psychologie, FMG), Faculteit der Geneeskunde, Anatomy and neurosciences, Psychiatry, and NCA - Neurobiology of mental health
- Abstract
Decision-making deficits are thought to play an important role in the development and persistence of substance use disorders. Individual differences in decision-making abilities and their underlying neurocircuitry may, therefore, constitute an important predictor for the course of substance use and the development of substance use disorders. Here, we investigate the predictive value of decision making and neural mechanisms underlying decision making for future cannabis use and problem severity in a sample of heavy cannabis users. Brain activity during a monetary decision-making task (Iowa gambling task) was compared between 32 heavy cannabis users and 41 matched non-using controls using functional magnetic resonance imaging. In addition, within the group of heavy cannabis users, associations were examined between task-related brain activations, cannabis use and cannabis use-related problems at baseline, and change in cannabis use and problem severity after a 6-month follow-up. Despite normal task performance, heavy cannabis users compared with controls showed higher activation during wins in core areas associated with decision making. Moreover, within the group of heavy cannabis users, win-related activity and activity anticipating loss outcomes in areas generally involved in executive functions predicted change in cannabis use after 6 months. These findings are consistent with previous studies and point to abnormal processing of motivational information in heavy cannabis users. A new finding is that individuals who are biased toward immediate rewards have a higher probability of increasing drug use, highlighting the importance of the relative balance between motivational processes and regulatory executive processes in the development of substance use disorders.
- Published
- 2013
44. Impulsregulatie en verslaving: een translationeel onderzoek [Impulse control in addiction: a translational perspective]
- Author
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Schmaal, L., Broos, N., Joos, L., Pattij, T., Goudriaan, A.E., Psychiatry, Anatomy and neurosciences, and NCA - Neurobiology of mental health
- Published
- 2013
45. P.1.j.031 The efficacy of N-acetylcysteine on smoking cessation, impulsivity and cue reactivity in heavy smokers
- Author
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Schulte, M.H.J., primary, Goudriaan, A.E, additional, Van den Brink, W., additional, Wiers, R.W, additional, and Schmaal, L., additional
- Published
- 2015
- Full Text
- View/download PDF
46. Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study
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Goudriaan, A.E., de Ruiter, M.B., van den Brink, W., Oosterlaan, J., Veltman, D.J., Psychiatry, NCA - Brain Imaging, Clinical Neuropsychology, and Neuroscience Campus Amsterdam - Brain Imaging
- Subjects
SDG 3 - Good Health and Well-being ,mental disorders - Abstract
Abnormal cue reactivity is a central characteristic of addiction, associated with increased activity in motivation, attention and memory related brain circuits. In this neuroimaging study, cue reactivity in problem gamblers (PRG) was compared with cue reactivity in heavy smokers (HSM) and healthy controls (HC). A functional magnetic resonance imaging event-related cue reactivity paradigm, consisting of gambling, smoking-related and neutral pictures, was employed in 17 treatment-seeking non-smoking PRG, 18 non-gambling HSM, and 17 non-gambling and non-smoking HC. Watching gambling pictures (relative to neutral pictures) was associated with higher brain activation in occipitotemporal areas, posterior cingulate cortex, parahippocampal gyrus and amygdala in PRG compared with HC and HSM. Subjective craving in PRG correlated positively with brain activation in left ventrolateral prefrontal cortex and left insula. When comparing the HSM group with the two other groups, no significant differences in brain activity induced by smoking cues were found. In a stratified analysis, the HSM subgroup with higher Fagerström Test for Nicotine Dependence scores (FTND M = 5.4) showed higher brain activation in ventromedial prefrontal cortex, rostral anterior cingulate cortex, insula and middle/superior temporal gyrus while watching smoking-related pictures (relative to neutral pictures) than the HSM subgroup with lower FTND scores (FTND M = 2.9) and than non-smoking HC. Nicotine craving correlated with activation in left prefrontal and left amygdala when viewing smoking-related pictures in HSM. Increased regional responsiveness to gambling pictures in brain regions linked to motivation and visual processing is present in PRG, similar to neural mechanisms underlying cue reactivity in substance dependence. Increased brain activation in related fronto-limbic brain areas was present in HSM with higher FTND scores compared with HSM with lower FTND scores. © 2010 Society for the Study of Addiction.
- Published
- 2010
47. Getting a grip on problem gambling: What can neuroscience tell us?
- Author
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Goudriaan, A.E., Yucel, M., Holst, R.J. van, Goudriaan, A.E., Yucel, M., and Holst, R.J. van
- Abstract
Contains fulltext : 135384.pdf (publisher's version ) (Open Access), In problem gamblers, diminished cognitive control and increased impulsivity is present compared to healthy controls. Moreover, impulsivity has been found to be a vulnerability marker for the development of pathological gambling (PG) and problem gambling (PrG) and to be a predictor of relapse. In this review, the most recent findings on functioning of the brain circuitry relating to impulsivity and cognitive control in PG and PrG are discussed. Diminished functioning of several prefrontal areas and of the anterior cingulate cortex (ACC) indicate that cognitive-control related brain circuitry functions are diminished in PG and PrG compared to healthy controls. From the available cue reactivity studies on PG and PrG, increased responsiveness towards gambling stimuli in fronto-striatal reward circuitry and brain areas related to attentional processing is present compared to healthy controls. At this point it is unresolved whether PG is associated with hyper- or hypo-activity in the reward circuitry in response to monetary cues. More research is needed to elucidate the complex interactions for reward responsivity in different stages of gambling and across different types of reward. Conflicting findings from basic neuroscience studies are integrated in the context of recent neurobiological addiction models. Neuroscience studies on the interface between cognitive control and motivational processing are discussed in light of current addiction theories. CLINICAL IMPLICATIONS: We suggest that innovation in PG therapy should focus on improvement of dysfunctional cognitive control and/or motivational functions. The implementation of novel treatment methods like neuromodulation, cognitive training and pharmacological interventions as add-on therapies to standard treatment in PG and PrG, in combination with the study of their effects on brain-behavior mechanisms could prove an important clinical step forward towards personalizing and improving treatment results in PG.
- Published
- 2014
48. Contingency learning in alcohol dependence and pathological gambling: learning and unlearning reward contingencies
- Author
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Vanes, L.D., Holst, R.J. van, Jansen, J.M., Brink, W. van den, Oosterlaan, J., Goudriaan, A.E., Vanes, L.D., Holst, R.J. van, Jansen, J.M., Brink, W. van den, Oosterlaan, J., and Goudriaan, A.E.
- Abstract
Contains fulltext : 137689.pdf (publisher's version ) (Open Access), BACKGROUND: Patients with alcohol dependence (AD) and pathological gambling (PG) are characterized by dysfunctional reward processing and their ability to adapt to alterations of reward contingencies is impaired. However, most neurocognitive tasks investigating reward processing involve a complex mix of elements, such as working memory, immediate and delayed rewards, and risk-taking. As a consequence, it is not clear whether contingency learning is altered in AD or PG. Therefore, the current study aimed to examine performance in a deterministic contingency learning task, investigating discrimination, reversal, and extinction learning. METHODS: Thirty-three alcohol-dependent patients (ADs), 28 pathological gamblers (PGs), and 18 healthy controls (HCs) performed a contingency learning task in which they learned stimulus-reward associations that were first reversed and later extinguished while receiving deterministic feedback throughout. Accumulated points, number of perseverative errors and trials required to reach a criterion in each learning phase were compared between groups using nonparametric Kruskal-Wallis rank-sum tests. Regression analyses were performed to compare learning curves. RESULTS: PGs and ADs did not differ from HCs in discrimination learning, reversal learning, or extinction learning, on the nonparametric tests. Regression analyses, however, showed differences in the initial speed of learning: PGs were significantly faster in discrimination learning compared to ADs, and both PGs and ADs learned slower than HCs in the reversal learning and extinction phases of the task. CONCLUSIONS: Learning rates for reversal and extinction were slower for the alcohol-dependent group and PG group compared to HCs, suggesting that reversing and extinguishing learned contingencies require more effort in ADs and PGs. This implicates a diminished flexibility to overcome previously learned contingencies.
- Published
- 2014
49. Enhanced striatal responses during expectancy coding in alcohol dependence
- Author
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Holst, R.J. van, Clark, L., Veltman, D.J., Brink, W. van den, Goudriaan, A.E., Holst, R.J. van, Clark, L., Veltman, D.J., Brink, W. van den, and Goudriaan, A.E.
- Abstract
Contains fulltext : 135381.pdf (publisher's version ) (Closed access), Individuals with alcohol dependence are known to make disadvantageous decisions, possibly caused by alterations in either reward or punishment sensitivity, which lead to persistent alcohol use despite its adverse consequences. Previous studies in alcohol dependence have mainly focused on reward anticipation processing and results from these studies are mixed. To clarify the nature of the motivational deficit that underlies disadvantageous choice in alcohol dependence, the current study sought to characterize the neural representation of expected value in individuals with alcohol dependence, separating expectancy-related processing of gains and losses, as a function of outcome magnitude and outcome probability. METHOD: Functional MRI was used to examine brain responses during the expectation of gains and losses in patients with alcohol dependence (n=19) and healthy controls (n=19). The task manipulated outcome magnitude (euro1 and euro5) and outcome probability (30% and 70%). RESULTS: Compared to healthy controls, patients with alcohol dependence were more responsive to the expectancy of large wins, in the caudate and putamen. This effect was driven by a higher caudate activity in the contrast comparing euro5 vs. euro1 trials in patients with alcohol dependence. There were no group differences in the responses to the expectancy for loss. The patient group reported lower expectancies of winning in the trial-by-trial ratings. CONCLUSIONS: Patients with alcohol dependence showed caudate hyperactivity when expecting wins. The result contrasts with past work using the monetary incentive delay task, showing caudate hypoactivity; the passive nature of our task contrasts with an active response requirement in the MIDT studies., BACKGROUND: Individuals with alcohol dependence are known to make disadvantageous decisions, possibly caused by alterations in either reward or punishment sensitivity, which lead to persistent alcohol use despite its adverse consequences. Previous studies in alcohol dependence have mainly focused on reward anticipation processing and results from these studies are mixed. To clarify the nature of the motivational deficit that underlies disadvantageous choice in alcohol dependence, the current study sought to characterize the neural representation of expected value in individuals with alcohol dependence, separating expectancy-related processing of gains and losses, as a function of outcome magnitude and outcome probability. METHOD: Functional MRI was used to examine brain responses during the expectation of gains and losses in patients with alcohol dependence (n=19) and healthy controls (n=19). The task manipulated outcome magnitude (euro1 and euro5) and outcome probability (30% and 70%). RESULTS: Compared to healthy controls, patients with alcohol dependence were more responsive to the expectancy of large wins, in the caudate and putamen. This effect was driven by a higher caudate activity in the contrast comparing euro5 vs. euro1 trials in patients with alcohol dependence. There were no group differences in the responses to the expectancy for loss. The patient group reported lower expectancies of winning in the trial-by-trial ratings. CONCLUSIONS: Patients with alcohol dependence showed caudate hyperactivity when expecting wins. The result contrasts with past work using the monetary incentive delay task, showing caudate hypoactivity; the passive nature of our task contrasts with an active response requirement in the MIDT studies.
- Published
- 2014
50. Cognitive inflexibility in gamblers is primarily present in reward-related decision making
- Author
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Boog, M.C. (Michiel), Höppener, P. (Paul), Wetering, B.J.M. (Ben) van de, Goudriaan, A.E. (Anna), Boog, M.C. (Matthijs), Franken, I.H.A. (Ingmar), Boog, M.C. (Michiel), Höppener, P. (Paul), Wetering, B.J.M. (Ben) van de, Goudriaan, A.E. (Anna), Boog, M.C. (Matthijs), and Franken, I.H.A. (Ingmar)
- Abstract
One hallmark of gambling disorder (GD) is the observation that gamblers have problems stopping their gambling behavior once it is initiated. On a neuropsychological level, it has been hypothesized that this is the result of a cognitive inflexibility.The present study investigated cognitive inflexibility in patients with GD using a task involving cognitive inflexibility with a reward element (i.e., reversal learning) and a task measuring general cognitive inflexibility without such a component (i.e., response perseveration). For this purpose, scores of a reward-based reversal learning task (probabilistic reversal learning task) and the Wisconsin card sorting task were compared between a group of treatment seeking patients with GD and a gender and age matched control group. The results show that pathological gamblers have impaired performance on the neurocognitive task measuring reward-based cognitive inflexibility. However, no difference between the groups is observed regarding non-reward-based cognitive inflexibility. This suggests that cognitive inflexibility in GD is the result of an aberrant reward-based learning, and not based on a more general problem with cognitive flexibility. The pattern of observed problems is suggestive of a dysfunction of the orbitofrontal cortex, the ventrolateral prefrontal cortex, and the ventral regions of the striatum in gamblers. Relevance for the neurocognition of problematic gambling is discussed.
- Published
- 2014
- Full Text
- View/download PDF
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