1,040 results on '"Gould, G."'
Search Results
2. Giri-nya-la-nha (talk together) to explore acceptability of targeted smoking cessation resources with Australian Aboriginal women
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Bovill, M., Bar-Zeev, Y., Gruppetta, M., Clarke, M., Nicholls, K., O'Mara, P., Bonevski, B., Reath, J., and Gould, G.
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- 2019
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3. Development and initial validation of the Bristol Impact of Hypermobility questionnaire
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Palmer, S., Cramp, F., Lewis, R., Gould, G., and Clark, E.M.
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- 2017
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4. The Glucose Transporter (GLUT-4) and Vesicle-Associated Membrane Protein-2 (VAMP-2) Are Segregated from Recycling Endosomes in Insulin-Sensitive Cells
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Martin, S., Tellam, J., Livingstone, C., Slot, J. W., Gould, G. W., and James, D. E.
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- 1996
5. Ethanol inhibits dopamine uptake via organic cation transporter 3:Implications for ethanol and cocaine co-abuse
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Clauss, N. J., Mayer, F. P., Owens, W. A., Vitela, M., Clarke, K. M., Bowman, M. A., Horton, R. E., Gründemann, D., Schmid, D., Holy, M., Gould, G. G., Koek, W., Sitte, H. H., Daws, L. C., Clauss, N. J., Mayer, F. P., Owens, W. A., Vitela, M., Clarke, K. M., Bowman, M. A., Horton, R. E., Gründemann, D., Schmid, D., Holy, M., Gould, G. G., Koek, W., Sitte, H. H., and Daws, L. C.
- Abstract
Concurrent cocaine and alcohol use is among the most frequent drug combination, and among the most dangerous in terms of deleterious outcomes. Cocaine increases extracellular monoamines by blocking dopamine (DA), norepinephrine (NE) and serotonin (5-HT) transporters (DAT, NET and SERT, respectively). Likewise, ethanol also increases extracellular monoamines, however evidence suggests that ethanol does so independently of DAT, NET and SERT. Organic cation transporter 3 (OCT3) is an emergent key player in the regulation of monoamine signaling. Using a battery of in vitro, in vivo electrochemical, and behavioral approaches, as well as wild-type and constitutive OCT3 knockout mice, we show that ethanol’s actions to inhibit monoamine uptake are dependent on OCT3. These findings provide a novel mechanistic basis whereby ethanol enhances the neurochemical and behavioral effects of cocaine and encourage further research into OCT3 as a target for therapeutic intervention in the treatment of ethanol and ethanol/cocaine use disorders., Concurrent cocaine and alcohol use is among the most frequent drug combination, and among the most dangerous in terms of deleterious outcomes. Cocaine increases extracellular monoamines by blocking dopamine (DA), norepinephrine (NE) and serotonin (5-HT) transporters (DAT, NET and SERT, respectively). Likewise, ethanol also increases extracellular monoamines, however evidence suggests that ethanol does so independently of DAT, NET and SERT. Organic cation transporter 3 (OCT3) is an emergent key player in the regulation of monoamine signaling. Using a battery of in vitro, in vivo electrochemical, and behavioral approaches, as well as wild-type and constitutive OCT3 knockout mice, we show that ethanol’s actions to inhibit monoamine uptake are dependent on OCT3. These findings provide a novel mechanistic basis whereby ethanol enhances the neurochemical and behavioral effects of cocaine and encourage further research into OCT3 as a target for therapeutic intervention in the treatment of ethanol and ethanol/cocaine use disorders.
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- 2023
6. Solutes and low water activity
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Russell, N. J., Leistner, L., Gould, G. W., Russell, N. J., editor, and Gould, Grahame W., editor
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- 2003
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7. Sulfite
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Gould, G. W., Russell, N. J., Russell, N. J., editor, and Gould, Grahame W., editor
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- 2003
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8. Major preservation technologies
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Russell, N. J., Gould, G. W., Russell, N. J., editor, and Gould, Grahame W., editor
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- 2003
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9. Major, new, and emerging food-poisoning and food-spoilage microorganisms
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Gould, G. W., Russell, N. J., Russell, N. J., editor, and Gould, Grahame W., editor
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- 2003
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10. Expression of Glucose Transporters in Xenopus laevis Oocytes: Applications for the Study of Membrane Transporter Function and Regulation
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Seatter, M. J., Gould, G. W., Lacal, Juan Carlos, editor, Feramisco, James, editor, and Perona, Rosario, editor
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- 1999
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11. EXPLORANDO DIFERENTES RECURSOS DIDÁTICOS NO ENSINO FUNDAMENTAL: UMA PROPOSTA PARA O ENSINO DE CÉLULA.
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Menglynn MCKERAL-GOULD, G. Lily, Lima RIBEIRO, Charles, Pereira LEMOS, Bruno, and Rodrigues CALDEIRA, Andreia Juliana
- Abstract
Copyright of Revista Agrotecnologia is the property of Universidade Estadual de Goias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
12. Analytic Properties of the Four-Point Green’s Function
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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13. Consequences for High-Energy Elementary Processes
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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14. Analyticity with respect to Momentum Transfer and Dispersion Relations
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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15. The S-Matrix Method
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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16. Lehmann-Symanzik-Zimmermann Formalism
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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17. Analytic Properties of Wightman Functions in Coordinate Space
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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18. Haag-Ruelle Scattering Theory
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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19. Examples: Explicitly Soluble Two-Dimensional Models
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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20. Fields in an Indefinite Metric
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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21. The Wightman Formalism
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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22. Algebra of Observables and State Space
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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23. The Jost-Lehmann-Dyson Representation
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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24. Relativistic Invariance in Quantum Theory
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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25. Analytic Functions of Several Complex Variables
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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26. Lorentz-Covariant Generalized Functions
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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27. The Technique of Generalized Functions
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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28. Preliminaries on Functional Analysis
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Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor
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- 1990
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29. Water Relations in Single Cells [and Discussion]
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Gould, G. W., Measures, J. C., Wilkie, D. R., and Meares, P.
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- 1977
30. Tertiary Hydrogen Bonds in the Solution Structure of Transfer RNA
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Reid, B. R., Ribeiro, N. S., Gould, G., Robillard, G., Hilbers, C. W., and Shulman, R. G.
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- 1975
31. E-099 Transition from proximal to distal radial access for diagnostic cerebral angiography: Learning curve analysis
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Hoffman, H, primary, Bunch, K, additional, Mikhailova, T, additional, Cote, J, additional, Ashok Kumar, A, additional, Masoud, H, additional, and Gould, G, additional
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- 2021
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32. E-100 Endovascular management of refractory nasopharyngeal and oropharyngeal bleeding: Case series
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Hoffman, H, primary and Gould, G, additional
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- 2021
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33. Building an Indigenous-Led Evidence Base for Smoking Cessation Care among Aboriginal and Torres Strait Islander Women during Pregnancy and Beyond: Research Protocol for the Which Way? Project
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Bovill, M, Chamberlain, C, Bennett, J, Longbottom, H, Bacon, S, Field, B, Hussein, P, Berwick, R, Gould, G, O'Mara, P, Bovill, M, Chamberlain, C, Bennett, J, Longbottom, H, Bacon, S, Field, B, Hussein, P, Berwick, R, Gould, G, and O'Mara, P
- Abstract
Strong and healthy futures for Aboriginal and Torres Strait Islander people requires engagement in meaningful decision making which is supported by evidence-based approaches. While a significant number of research publications state the research is co-designed, few describe the research process in relation to Indigenous ethical values. Improving the health and wellbeing of Aboriginal and Torres Strait Islander mothers and babies is crucial to the continuation of the oldest living culture in the world. Developing meaningful supports to empower Aboriginal and Torres Strait Islander mothers to quit smoking during pregnancy is paramount to addressing a range of health and wellbeing outcomes. Aboriginal and Torres Strait Islander women have called for non-pharmacological approaches to smoking cessation during pregnancy. We describe a culturally responsive research protocol that has been co-designed and is co-owned with urban and regional Aboriginal communities in New South Wales. The project has been developed in line with the AH&MRC's (Aboriginal Health & Medical Research Council) updated guidelines for ethical research with Aboriginal and Torres Strait Islander communities. Ethics approvals have been granted by AH&MRC #14541662 University of Newcastle HREC H-2020-0092 and the Local Health District ethics committee 2020/ETH02095. Results will be disseminated through peer reviewed articles, community reports, infographics, and online social media content.
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- 2021
34. Isolation of a variant infectious bronchitis virus in Australia that further illustrates diversity among emerging strains
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Ignjatovic, J., Gould, G., and Sapats, S.
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- 2006
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35. Chicken recombinant antibodies specific for very virulent infectious bursal disease virus
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Sapats, S. I., Trinidad, L., Gould, G., Heine, H. G., van den Berg, T. P., Eterradossi, N., Jackwood, D., Parede, L., Toquin, D., and Ignjatovic, J.
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- 2006
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36. Finding the Right Candidate — Part II
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Raymond Gould, G.
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- 1990
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37. Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats
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Collison, M., James, D. J., Graham, D., Holman, G. D., Connell, J. M. C., Dominiczak, A. F., Gould, G. W., and Salt, I. P.
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- 2005
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38. Generation of chicken single chain antibody variable fragments (scFv) that differentiate and neutralize infectious bursal disease virus (IBDV)
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Sapats, S. I., Heine, H. G., Trinidad, L., Gould, G. J., Foord, A. J., Doolan, S. G., Prowse, S., and Ignjatovic, J.
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- 2003
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39. Antibody Expression and Engineering
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HENRY Y. WANG, TADAYUKI IMANAKA, D. K. Robinson, D. DiStefano, S. L. Gould, G. Cuca, T. C. Seamans, D. Benincasa, S. Munshi, C. P. Chan, J. Stafford-Hollis, G. F. Hollis, D. Jain, K. Ramasubramanyan, G. E. Mark, M. Siberklang, Hidekazu Sawada, Kazuaki Kitano, R. S. Barnett, K. L. Limoli, T. B. Huynh
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- 1995
40. Long-term insulin treatment of 3T3-L1 adipocytes results in mis-targeting of GLUT4: implications for insulin-stimulated glucose transport
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Maier, V. H. and Gould, G. W.
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- 2000
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41. Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins
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Collison, M., Campbell, I. W., Salt, I. P., Dominiczak, A. F., Connell, J. M. C., Lyall, H., and Gould, G. W.
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- 2000
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42. Preservation principles and new technologies
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Gould, G., primary
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- 2009
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43. Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects
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Barba-Escobedo, P. A. and Gould, G. G.
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- 2012
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44. Pathogen resistance and adaptation to emerging technologies
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Gould, G., primary
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- 2005
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45. PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injury: Poster Presentation No.: P094
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Huang, Yiyun, Nabulsi, N., Weinzimmer, D., Fung, E., Ropchan, J., Labaree, D., Wang, X., Gould, G., Frost, J. J., Carson, R. E., and Strittmatter, S. M.
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- 2008
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46. National survey of College Tutors in the UK regarding training in medical education
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Rashid, A., Doger, A., and Gould, G.
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- 2008
47. The role of context in implementation research for non-communicable diseases: Answering the 'how-to' dilemma
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Daivadanam, M, Ingram, M, Annerstedt, KS, Parker, G, Bobrow, K, Dolovich, L, Gould, G, Riddell, M, Vedanthan, R, Webster, J, Absetz, P, Alvesson, HM, Androutsos, O, Chavannes, N, Cortez, B, Devarasetty, P, Fottrell, E, Gonzalez-Salazar, F, Goudge, J, Herasme, O, Jennings, H, Kapoor, D, Kamano, J, Kasteleyn, MJ, Kyriakos, C, Manios, Y, Mogulluru, K, Owolabi, M, Lazo-Porras, M, Silva, W, Thrift, A, Uvere, E, Webster, R, Van der Kleij, R, Van Olmen, J, Vardavas, C, Zhang, P, Almeda-Valdes, P, Britton, J, Cristobal, F, Delobelle, P, Gonzalez, C, Guwatudde, D, Gyamfi, J, Johnson, C, Kirkham, R, Lopez-Jaramillo, P, Lucero, VP, Mills, K, Oldenburg, B, Patel, A, Saulson, R, Silva, N, Trieu, K, GACD Concepts Contexts Working Grp, and Public Health Sciences
- Subjects
Lung Diseases ,Male ,lung disease ,Knowledge management ,International Cooperation ,Health Care Providers ,Psychological intervention ,Stakeholder engagement ,Blood Pressure ,030204 cardiovascular system & hematology ,Global Health ,Vascular Medicine ,medical research ,interpersonal communication ,0302 clinical medicine ,Endocrinology ,Surveys and Questionnaires ,Health care ,Medicine and Health Sciences ,Public and Occupational Health ,030212 general & internal medicine ,health service ,Qualitative Research ,Aged, 80 and over ,Multidisciplinary ,quantitative analysis ,Geography ,Health services research ,methodology ,Public Health, Global Health, Social Medicine and Epidemiology ,SCIENCE ,Middle Aged ,Research Assessment ,health care planning ,health survey ,3. Good health ,Multidisciplinary Sciences ,Treatment Outcome ,Research Design ,Hypertension ,Medicine ,Science & Technology - Other Topics ,Female ,Health Services Research ,Engineering sciences. Technology ,Research Article ,Adult ,Endocrine Disorders ,General Science & Technology ,Qualitative property ,Context (language use) ,Health Promotion ,Research and Analysis Methods ,Community Based Intervention ,Article ,03 medical and health sciences ,purl.org/pe-repo/ocde/ford#3.03.02 [https] ,Stakeholder Participation ,Diabetes Mellitus ,cross-sectional study ,qualitative analysis ,Humans ,GACD Concepts and Contexts working group ,Noncommunicable Diseases ,Poverty ,Aged ,Internet ,Health Care Policy ,Science & Technology ,business.industry ,questionnaire ,stakeholder engagement ,non communicable disease ,MIXED METHODS ,Health Care ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Cross-Sectional Studies ,Metabolic Disorders ,Chronic Disease ,Implementation research ,business ,Delivery of Health Care ,Qualitative research - Abstract
IntroductionUnderstanding context and how this can be systematically assessed and incorporated is crucial to successful implementation. We describe how context has been assessed (including exploration or evaluation) in Global Alliance for Chronic Diseases (GACD) implementation research projects focused on improving health in people with or at risk of chronic disease and how contextual lessons were incorporated into the intervention or the implementation process.MethodsUsing a web-based semi-structured questionnaire, we conducted a cross-sectional survey to collect quantitative and qualitative data across GACD projects (n = 20) focusing on hypertension, diabetes and lung diseases. The use of context-specific data from project planning to evaluation was analyzed using mixed methods and a multi-layered context framework across five levels; 1) individual and family, 2) community, 3) healthcare setting, 4) local or district level, and 5) state or national level.ResultsProject teams used both qualitative and mixed methods to assess multiple levels of context (avg. = 4). Methodological approaches to assess context were identified as formal and informal assessments, engagement of stakeholders, use of locally adapted resources and materials, and use of diverse data sources. Contextual lessons were incorporated directly into the intervention by informing or adapting the intervention, improving intervention participation or improving communication with participants/stakeholders. Provision of services, equipment or information, continuous engagement with stakeholders, feedback for personnel to address gaps, and promoting institutionalization were themes identified to describe how contextual lessons are incorporated into the implementation process.ConclusionsContext is regarded as critical and influenced the design and implementation of the GACD funded chronic disease interventions. There are different approaches to assess and incorporate context as demonstrated by this study and further research is required to systematically evaluate contextual approaches in terms of how they contribute to effectiveness or implementation outcomes.
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- 2019
48. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA
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McGuire D, Alexander J, Johansen O, Perkovic V, Rosenstock J, Cooper M, Wanner C, Kahn S, Toto R, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George J, von Eynatten M, Marx N, Aizenberg D, Fiorella A, Edgardo N, Belen C, Alonso P, Walter M, Maia K, Guillermo S, Leandro B, Constanza R, Alejandra N, Melina C, Ariel I, Rodrigo C, Alvarez C, Jorge M, Gabriel C, German S, Bartolacci I, Bolobanich G, Tale T, Meritano M, Echeverria M, Gerrini S, Alvarez M, Torrijos N, Berli M, Coggiola J, Castaneda G, Rode R, Milessi R, Roude A, Bono J, Caresani J, Arias V, Westberg J, Allende G, Liberman A, Bordonava A, Almagro S, Gerbaudo C, Schiavi L, Budassi N, Cecilia M, Buncuga M, Carlos S, Osvaldo T, Mercedes S, Calella P, Agustina V, Aljandro M, Alberto D, Fiorella M, Cantero M, Cariganano M, Anadon P, Cartasegna L, Gabriela M, Fernanda A, Alberto R, Chacon C, Jazmin F, Colombo H, Coni E, Mattausch S, Thomsenhall K, della Torre M, Morandini M, Berra F, Margarita H, Commendatore V, Tedesco J, Bolzan P, Cuneo C, Narcisa G, Caputi V, Pablo S, Sandra G, Pacora F, Tinari M, Jure H, Parody M, Toranzo A, Frechtel G, Yohena S, Lovecchio S, Muller C, Martin S, Olivera C, Breyaui M, Bianchi G, Garcia C, Luciana V, Florencia F, Ruben G, Gelersztein E, Rey G, Sanchez C, Fornasari L, Di Pierro L, Giacomi G, Miguel S, Laura T, Gonzalo C, Ramon C, Glenny J, Koretzky M, Porto A, Tiberio O, Ellenberg A, Saurral R, Igarzabal C, Vilamajo O, Matkovich J, de Lapertosa S, Villagra M, Cuzziol G, de la Cruz M, Pinchetti R, Mierez M, Lopez C, Gorosito V, Gabito A, Kleiban A, Grosembacher L, Adrian P, Paula R, Javier G, Kraft F, Andres F, Krynski F, Nicolas P, Marcelo F, Alfredo F, de la Fuente R, Natalia C, Luquez H, Recuero Y, Becchetti N, Ruiz M, Costantino M, Vazquez G, Guzman C, Pelatia P, Maffei L, Sassone S, Yantorno M, Prado G, Khron B, Maldonado N, Gustavo L, Veronica V, Marino J, Elizabeth A, Alejandra C, Oscar R, Azize G, Gallardo M, Escudero M, Vargas E, Ramos H, Lucero C, Najenson M, Crocci I, Chiesa A, Nardone L, Dominguez S, Zanini A, Manghi F, Grossman M, Giudice G, Romeo A, Piskorz D, Miguel C, Susana D, Noeli U, Rosa S, Martin V, Soledad A, Virginia M, Lorena G, Prado A, Veronica L, Eduardo H, Adolfo P, Florencia W, Rista L, Scolari C, Rojas N, Bertolio V, Zarandon R, Jair S, Orlando C, Sanabria H, Ignacio D, Viviana C, Marina R, Sarjanovich R, Scaro G, Huerta C, Mana M, Gutierrez M, Dain A, Gavicola R, Sessa H, Sacripanti J, Felman R, Vilarino P, Sicer M, Lagrutta M, Sala J, Casabella T, Cecilia H, Carlos B, Vines G, Javier R, Vico M, Lanchiotti P, Martella C, Torres L, Villarino A, Molina M, Martinez J, Farias C, Bertola S, Rojas M, Guzman P, Nisi J, Martinez D, Barrionuevo M, Vita N, Lopez A, Vottero E, Giuliano M, Paron L, Vogel D, Mele P, Imposti H, Dominguez A, Zaidman C, Fernando G, Beck M, Beltrame P, Chemello D, Junior R, Abreu A, Fernandes V, Saboia J, Rodrigues L, Carvalho M, Gurgel M, Gadelha D, Ramos C, Borba V, Golbert M, Pitthan M, Golbert L, 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Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, 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V, Camelia T, Oana P, Monia A, Onaca A, Mircea O, Mot A, Stolea V, Elena N, Barbonta D, Cristian B, Oana S, Popescu A, Madalina M, Coman A, Anca C, Constantinescu S, Mircea C, Diaconu-Sotropa M, Ene D, Pintilei E, Mihai G, Delia R, Toarba I, Simona H, Negru D, Flaminzeanu F, Iulian C, Maria-Cristina C, Doros R, Cleo S, Sorin B, Demian L, Mihai S, Raul B, Ioana A, Nicolau A, Cosmin P, Isabela G, Elena C, Ileana T, Valuyskikh E, Miroshnichenko E, Klementyeva N, Zelman O, Chumakova G, Vigel A, Leonova N, Pergaeva Y, Stefanovskaya O, Pushkareva S, Antoshkina L, Zheleznova N, Iveitsman, Barbarash O, Zvereva T, Zhuravleva E, Zavyrylina I, Usoltceva E, Savostyanova Y, Kupriyanova T, Krivoshapova K, Kondyukova N, Inozemceva A, Argunova Y, Tsyba L, Belenky D, Mariich O, Terekhova A, Tsygankova O, Kuznetsova E, Nagibovich G, Ivchenko Y, Dobronravov V, Dobronravov A, Bush M, Trofimenko I, Vishnevsky A, Zikov V, Kositsyn D, Palzman Z, Spiridonova T, Rodina N, Polozhentsev S, Mamedova L, Panov A, 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Delport E, Mathijs S, Soma P, van Zyl D, Strydom M, Marais A, Badat A, Hansa S, Fourie D, Walton T, Engelbrecht J, Jansen J, Roos J, du Toit S, Lehloenya K, van Zyl L, van Zyl F, Naude M, Mookadam M, van der Merwe A, Trokis J, Lombard L, Coetzee K, Ismail S, Bruning H, Latiff G, Yasmin O, Pillay T, Mohamed Z, Dawood S, Stapelberg A, Abrahams P, Jurgens J, van Heerden P, Swart E, Botha C, Meeding J, Hemus A, Oosthuysen W, Visagie G, Fourie N, Hutton P, van der Merwe N, Chelin N, Everton T, Duki M, Ghila N, Joshi M, Hira M, Madueno F, Martinez B, Sebastian N, Mercadal L, Isbert S, Gonzalez I, Asencio J, Figueras M, Rivas M, Garcia H, Fusalba A, Geat D, Cambra G, Sastre J, Castro F, Mas A, Portillo C, Serrano I, Hernandez S, Fajardo F, Juan C, Ferrer J, Peralta F, Padin C, Mauricio D, Madorell B, San Miguel F, Pedrol N, Trescoli C, Montanana C, Gonzalo M, Capellan J, Estrella A, Martinez C, Montesinos I, Loscos A, Coronado J, Perez J, Castillo B, Alonso C, Quesada V, Teruel J, Perez S, 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Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
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cardiovascular disease ,type 2 diabetes mellitus ,heart failure ,chronic kidney diseases - Abstract
Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increased HF risk. We performed secondary analyses of HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin), a cardiovascular outcomes trial that enrolled participants with type 2 diabetes mellitus and atherosclerotic cardiovascular disease and/or kidney disease. Methods: Participants in 27 countries with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease were randomized 1:1 to receive once daily oral linagliptin 5 mg or placebo, on top of standard of care. All hospitalization for HF (hHF), cardiovascular outcomes, and deaths were prospectively captured and centrally adjudicated. In prespecified and post hoc analyses of HF and related events, Cox proportional hazards models adjusting for region and baseline history of HF were used. Recurrent hHF events were analyzed using a negative binomial model. In a subset of participants with left ventricular ejection fraction captured within the year before randomization, HF-related outcomes were assessed in subgroups stratified by left ventricular ejection fraction > or 50%. Results: CARMELINA enrolled 6979 participants (mean age, 65.9 years; estimated glomerular filtration rate, mL/min per 1.73m(2); hemoglobin A1c, 8.0%; 62.9% men; diabetes mellitus duration, 14.8 years), including 1873 (26.8%) with a history of HF at baseline. Median follow-up was 2.2 years. Linagliptin versus placebo did not affect the incidence of hHF (209/3494 [6.0%] versus 226/3485 [6.5%], respectively; hazard ratio [HR], 0.90; 95% CI, 0.74-1.08), the composite of cardiovascular death/hHF (HR, 0.94; 95% CI, 0.82-1.08), or risk for recurrent hHF events (326 versus 359 events, respectively; rate ratio, 0.94; 95% CI, 0.75-1.20). There was no heterogeneity of linagliptin effects on hHF by history of HF at baseline, baseline estimated glomerular filtration rate or urine albumin-creatinine ratio, or prerandomization left ventricular ejection fraction. Conclusions: In a large, international cardiovascular outcome trial in participants with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease, linagliptin did not affect the risk of hHF or other selected HF-related outcomes, including among participants with and without a history of HF, across the spectrum of kidney disease, and independent of previous left ventricular ejection fraction. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01897532.
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- 2019
49. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk The CARMELINA Randomized Clinical Trial
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Feldman D, Fujino Y, Kitamura H, Toriumi Y, Ishiguro H, Naganuma T, Shu S, Suzuki K, Hirota Y, Hayashi T, Hozawa K, Fukui T, Abe Y, Yamauchi K, Maruyama M, Matsumura S, Kozuma R, Nagai Y, Kihara Y, Maeda H, Nakanishi K, Iitsuka T, Hatori M, Shinozaki Y, Akiyama D, Kawabe M, Takei M, Sato A, Kawai Y, Kitajima K, Ide M, Sato N, Morisaki H, Nakashima K, Takayanagi H, Watanabe H, Iwahashi N, Tsujimoto M, Hibuse K, Hata T, Ueno K, Tatsuma H, Wakida Y, Ito T, Mizuno R, Fujita H, Konishi N, Kanehira T, Watanabe R, Miyaoka H, Okada T, Yamamoto M, Okita S, Murakami H, Todo Y, Umeoka F, Hori K, Shiraishi K, Tada F, Shimizu T, Tamai J, Sasaki C, Okuzima Y, Yasuda M, Iwaita Y, Tanaka K, Rha S, Na J, Cho D, Cho Y, Hwang E, Choi T, Won K, Kim H, Kim S, Oh D, Lee J, Choi H, Chung H, Park H, Suh Y, Kim Y, Kim N, Kim K, An J, Kim J, Park K, Kwak S, Kim M, Hwangbo Y, Lee D, Hong A, Kim L, Oh C, Moon S, Jung C, Jin J, Hyun B, Yang Y, Kong S, Yoon K, Yang H, Hong T, Oh J, Park J, Lee H, Choi J, Ahn J, Han S, Park W, Jo S, Suh S, An W, Park M, Lee S, Kim D, Jin H, Seo J, Chung C, Lim J, Huh J, Park I, Yu S, Sim N, Khan S, Albakari N, Sivaraman J, Manaf K, Maharuddin I, Nagendram S, Ali N, Abdul Latiff N, Othman N, Sarip S, Chew E, Mohamed S, Aziz N, Hui K, Lin L, Velaiutham S, Khir A, Lee L, Manikam S, Chooi K, Chang M, Ooi C, Anthony J, Seganathirajah M, Ng O, Ismail N, Cheah C, Ramanathan G, Mui N, Wen F, Choo T, Bin Ruhani A, Jamaludin S, Abidin S, Nor F, Abu Hassan M, Hanari N, Ahmad N, Suan M, Zainul N, Ali S, Sridhar G, Han C, Chin A, Vin L, Kadir K, Zain A, Hussain N, Pusparajah P, Lozano F, Gomez A, Zaccari E, Vigil A, Preciado C, de Leon M, Parra M, Cervantes A, Aguirre E, Orozco E, Gonzalez S, Elizondo R, Flores E, Guerrero M, Flores F, Sanchez J, Perez F, Rodriguez J, Martinez L, Marquez D, Gutierrez B, Flores M, Real M, Campos P, Garcia P, Rios M, Romero E, Perez Z, Tarabay C, Munoz L, Farias J, Gonzalez J, Palestino N, Sanchez L, Carrillo G, Ordonez N, Pech C, Andrade M, Euan J, Ortegon M, Garcia S, Orozco J, Vazquez H, Herrera R, Perez E, Arango A, Ibarra M, Gonzales L, Esperano J, Quintana L, Salazar I, Ruiz L, Barron C, Ballesteros C, Cervera L, Hercilla E, Gomez H, Mesa J, Herrera P, Rodriguez M, Ochoa R, Mora E, Charles C, Silva R, Mijangos J, Diaz C, Zavala C, Baron P, Bernal A, Martinez F, Tlapale M, Ramirez E, Basila A, Munguia R, Tello M, Martinez M, Mulder H, van der Graaff P, Nawaz A, Keller I, Schoofs M, Smak-Gregoor P, Al-Windy N, Bulut S, de Jong J, Maas A, Schaardenburgh P, Imholz B, Heijster J, Hoogenberg K, Smit C, Kooy A, Huvers F, Landewe-Cleuren S, Kars M, van Moorsel D, Wolffenbuttel B, Lutgens H, Schutte E, Gansevoort R, Idzerda N, Westerink J, Weijmans M, Berg J, van Kleef M, Slob M, Jaspers N, Hovens M, Monajemi H, Kobielusz-Gembala I, Zmuda W, Adamczyk M, Konieczny M, Strzelecka-Sosik A, Nowacka E, Krzyzagorska E, Sekulska M, CzajkowskaKaczmarek E, Kaczmarek B, Opawska K, Dabrowska M, Kus W, Wrzesien-Kus A, Piotrowski G, Hotlos L, Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, Gmytrasiewicz M, Zambrzycki J, Krysiak-Kowaluk H, Klodawska K, Klszczewski Z, Zieleniewski J, Opadczuk P, Urbanska K, Faran-Grabowska K, Szczepanik T, Siegel A, Kleczek A, Kincel K, Nowak D, Slowik-Gomulka L, Watemborska-Matuszyk G, Lampart J, Strozik-Krecichwost A, Dziewit T, Broncel M, Wojcik-Odyniec J, Jakubczyk E, Wierzbicka K, Witowicz A, Jedrych B, Korczyk P, Socik-Pojawa M, Monteiro P, Monteiro S, Mendes P, Soares F, Mendes S, Leite L, Vicente J, Santos M, Ferreira A, Alves P, Rosario F, Garrao A, Duarte L, Rogado C, Duarte R, Laginha T, Matos P, Raposo J, Mariz J, Teixeira J, Capela C, Leitao A, Cardiga R, Alface M, Augusto S, Basto L, Cunha A, Rei D, Dantas J, Verdasca I, Andrade L, Silva A, Suarez M, Dias V, Silva J, Pereira N, Goncalves M, Goncalves A, Silveira A, Sampaio A, Dias A, Diogo M, Vilaca C, Cif A, Calin T, Elena S, Crisan C, Adina S, Ramona S, Anghel V, Simona C, Turcu L, Mihaela V, Cosma D, Cristina H, Marius-Calin H, Negrisanu G, Andreea-Andrada M, Maria-Mihaela V, Camelia T, Oana P, Monia A, Onaca A, Mircea O, Mot A, Stolea V, Elena N, Barbonta D, Cristian B, Oana S, Popescu A, Madalina M, Coman A, Anca C, Constantinescu S, Mircea C, Diaconu-Sotropa M, Ene D, Pintilei E, Mihai G, Delia R, Toarba I, Simona H, Negru D, Flaminzeanu F, Iulian C, Maria-Cristina C, Doros R, Cleo S, Sorin B, Demian L, Mihai S, Raul B, Ioana A, Nicolau A, Cosmin P, Isabela G, Elena C, Ileana T, Valuyskikh E, Miroshnichenko E, Klementyeva N, Zelman O, Chumakova G, Vigel A, Leonova N, Pergaeva Y, Stefanovskaya O, Pushkareva S, Antoshkina L, Zheleznova N, Iveitsman, Barbarash O, Zvereva T, Zhuravleva E, Zavyrylina I, Usoltceva E, Savostyanova Y, Kupriyanova T, Krivoshapova K, Kondyukova N, Inozemceva A, Argunova Y, Tsyba L, Belenky D, Mariich O, Terekhova A, Tsygankova O, Kuznetsova E, Nagibovich G, Ivchenko Y, Dobronravov V, Dobronravov A, Bush M, Trofimenko I, Vishnevsky A, Zikov V, Kositsyn D, Palzman Z, Spiridonova T, Rodina N, Polozhentsev S, Mamedova L, Panov A, Abesadze I, Alugishvili M, Ivashkin V, Drapkina O, Korneeva O, Zyatenkova E, Glinkina I, Poluboyarinova I, Gurova O, Raykhman A, Vertkin A, Rodykova I, Shamaeva K, Petrovskaya T, Uzueva E, Milovanov Y, Milovanova S, Milovanova L, Markina M, Dobrosmyslov I, Markov V, Afanasiev S, Babich E, Belokopytova N, Demyanov S, Maximov A, Maximov I, Rebrova T, Shtatolkina M, Masin A, Demko A, Chuyko O, Pronina A, Charf G, Akatova E, Urlaeva I, Nikolin O, Khovaeva Y, Ermachkova L, Burdina E, Shvalb P, Suchkov I, Pshennikov A, Gryaznov S, Rymar O, Dolinskaya Y, Bahareva Y, Mustafina S, Sherbakova L, Ovsyannikova A, Bolshakova O, Polunicheva E, Dora S, Agafyina A, Yashina A, Vasilieva I, Yakhontova P, Selivanova S, Kargapoltseva O, Shilina N, Bayramova G, Sorokin I, Astamirova K, Kuchuk P, Koniushenko D, Malykh N, Dvorkin M, Krovelets T, Konovalova K, Seeber M, van Niekerk F, Siebert H, Steenkamp W, Wiid S, Noeth M, Siebert R, Breedt J, Bouwer J, Kapp C, Venter T, Rayner B, Trinder Y, Rheeder P, Delport E, Mathijs S, Soma P, van Zyl D, Strydom M, Marais A, Badat A, Hansa S, Fourie D, Walton T, Engelbrecht J, Jansen J, Roos J, du Toit S, Lehloenya K, van Zyl L, van Zyl F, Naude M, Mookadam M, van der Merwe A, Trokis J, Lombard L, Coetzee K, Ismail S, Bruning H, Latiff G, Yasmin O, Pillay T, Mohamed Z, Dawood S, Stapelberg A, Abrahams P, Jurgens J, van Heerden P, Swart E, Botha C, Meeding J, Hemus A, Oosthuysen W, Visagie G, Fourie N, Hutton P, van der Merwe N, Chelin N, Everton T, Duki M, Ghila N, Joshi M, Hira M, Madueno F, Martinez B, Sebastian N, Mercadal L, Isbert S, Gonzalez I, Asencio J, Figueras M, Rivas M, Garcia H, Fusalba A, Geat D, Cambra G, Sastre J, Castro F, Mas A, Portillo C, Serrano I, Hernandez S, Fajardo F, Juan C, Ferrer J, Peralta F, Padin C, Mauricio D, Madorell B, San Miguel F, Pedrol N, Trescoli C, Montanana C, Gonzalo M, Capellan J, Estrella A, Martinez C, Montesinos I, Loscos A, Coronado J, Perez J, Castillo B, Alonso C, Quesada V, Teruel J, Perez S, Lama M, del Rio E, Zlova T, Ponomarenko K, Karpenko O, Bezuglova S, Mitskevych L, Kizim S, Nevolina I, Katerenchuk V, Liudmyla B, Ivan K, Rudyk I, Olena M, Anna I, Ganna B, Topchii I, Semenovykh P, Yulia Y, Mykhalchyshyn G, Kirienko D, Kobiliak N, Bodnar, Mykhalchyshyn, Pertseva N, Olena G, Tomashkevych H, Korpachev V, Prybyla O, Kovalchuk A, Kushnarova N, Zinych O, Tseluyko V, Andriy Z, Olga R, Mankovskyy B, Zherdova N, Lykhoshapko O, Logoida P, Godlevska O, Olena V, Olga C, Gyrina O, Alifer O, Dozhuk K, Pekhenko V, Gorobets N, Korneichuk A, Makarenko E, Martynyuk L, Martynuyk O, Stanislavchuk M, Larysa P, Natalia S, Botsyurko V, Kostitska I, Dzeman O, Ablitsov Y, Ivaseiko S, Konovart O, Sandurska S, Vendzilovych Y, Samoylov O, Iryna C, Rozhkivska L, Ulyanchenko I, Kateryna V, Orlenko V, Ivaskina K, Tronko M, Tronko K, Pashkovska N, Stankova N, Vynnychenko L, Bolotnikova N, Demokhova N, Reshotko D, Popova A, Dr Bogdana, Tetiana S, Svitlana D, Oksana R, Vlasenko M, Litvinova S, Semenyuk I, Fishchuk O, Mostovoy Y, Tkachenko T, Ovcharuk M, Rasputina L, Vakaliuk I, Tymochko N, Drapchak I, Petrovska L, Lai W, Yen H, Voon W, Lin T, Cheng K, Chiu C, Chu C, Hsu P, Chiang C, Li Y, Kuo C, Lin S, Chao T, Yu W, Sung S, Wang K, Lu T, Shih K, Wu C, Chiang F, Hwang J, Tsai C, Juang J, Jeng J, Tang S, Lai C, Cheng C, Hsieh I, Hsieh M, Chen C, Lee C, Pai P, Ko P, Wang T, Chen T, Wu H, Chang S, Chen K, Hsieh L, Chou C, Jiang J, Lee M, Huang J, Chen J, Chiu K, Tsai L, Chen P, Saxena M, Collier D, Vaidya B, Harman S, Ramell M, Davies M, Chatterjee S, Meakin L, Quinn M, Bain S, Mallipedhi A, Min T, Bashir J, Blagden M, Ali J, McCrimmon R, Brennan G, Malcolm E, McDonald D, Pearson E, Illsley G, Darzy K, Winocour P, Hanif W, Cockwell P, Charlton M, Thekkepat S, Howat I, Devers M, Patrick J, Wyatt N, Smith C, Singh B, Nicholas J, Gillani S, Green F, Bell E, Boyle J, MacKin S, Livingstone R, Arif A, Syed M, Hammoud J, Sparks J, Anderson M, Tumey R, Condit J, Reddy M, Abalos-Galito M, Rebecca J, Barker T, Seaton B, Campbell E, Kompanik H, Jayson L, Huffman C, Bialow M, McDonnell G, McCaffrey J, Manis C, DeLuca E, Levins J, Bartlett M, Anorga K, Franco M, Gentry P, Hodge D, Pohil R, Rschultz, Leggett R, Blair L, Gisler J, Niegos F, Osburn M, Parma K, Schendel S, Stines L, Winnie M, Wu P, Canales J, Yu J, Cornett G, Beavins J, Hyde D, Zapinski D, Johnson T, Levinson D, Ahmed A, Kenny B, Kuehl A, Bates C, Jantzi C, Ananthula P, Shafer J, Louthan J, Bays A, Stapleton A, Staton P, Strum D, Taylor P, Smith A, Rapp R, Bao S, Randolph C, MacGillivray B, Schuster R, Harden T, Barnella C, Dunnam T, Whiles R, Bolick C, Brockmyre A, Plucker S, Marshall C, Poteet C, Morin D, Tavel E, Averill N, McFann A, Purcell D, Dixon T, Corey E, Goss J, Drescher R, Irfan M, Naeem M, Egelhof R, Mehta P, Koehler T, Walia J, Fernandez J, Bedel G, Preet R, Bhuchar S, Ahmed F, Onyema D, Benchabbat A, Kohanbash L, Miller P, Lalinde M, Carrithers E, Patterson R, Raube-Miceli A, Martinez A, Harris B, Levy R, Siev E, Berlin H, DiMattia M, Sugimoto D, Dugas J, Benson M, Stegemoller R, Schmoll M, Kinnaman S, O'Connor T, Powel T, Rudolph L, Lewiecki M, Best E, Chavez J, Garcia M, Cohen R, Colman D, Ocampo M, Heaney L, Rappley G, Quezada I, Santos V, Nikfarjam A, Reyes M, Rodriguez R, Josephs L, Hernandez R, Flores P, Espinoza L, Mejia W, Pedraza Z, Castaneda R, Laguerre J, Cook R, Patel R, Werner H, Blank R, Small S, Andersen J, Holmes D, Farmer M, Wiener V, Pharr W, Bray B, Beekman J, Anderson A, Andrawis N, Gabra N, Moche T, Marty S, Galvez O, Reyes R, Garcia R, Lerma G, Pliquin B, Mayfield R, Durham N, Phillips R, Baran A, Kondo N, Dempsey S, Kufs W, Laddis T, Zimmer K, Van Depol M, Dweck L, Kestler M, Werner N, Ashraf M, Quick A, Schallert G, Sligh T, Trueba P, Batista J, Martinez T, Moya J, Amarales V, Santos E, Torres P, Diaz T, Diaz J, Hodish I, Else T, Buras E, Moratis A, Valika S, Rahman A, Malalis W, Box E, Box P, Kerwood B, Nagaeva J, Metz C, Hinnant J, Griswell D, 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- Abstract
IMPORTANCE Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease. OBJECTIVE To evaluate the effect of linagliptin, a selective DPP-4 inhibitor, on CV outcomes and kidney outcomes in patients with type 2 diabetes at high risk of CV and kidney events. DESIGN, SETTING, AND PARTICIPANTS Randomized, placebo-controlled, multicenter noninferiority trial conducted from August 2013 to August 2016 at 605 clinic sites in 27 countries among adults with type 2 diabetes, hemoglobin A(1c) of 6.5% to 10.0%, high CV risk (history of vascular disease and urine-albumin creatinine ratio [UACR] > 200mg/g), and high renal risk (reduced eGFR and micro-or macroalbuminuria). Participants with end-stage renal disease (ESRD) were excluded. Final follow-up occurred on January 18, 2018. INTERVENTIONS Patients were randomized to receive linagliptin, 5 mg once daily (n = 3494), or placebo once daily (n = 3485) added to usual care. Other glucose-lowering medications or insulin could be added based on clinical need and local clinical guidelines. MAIN OUTCOMES AND MEASURES Primary outcomewas time to first occurrence of the composite of CV death, nonfatalmyocardial infarction, or nonfatal stroke. Criteria for noninferiority of linagliptin vs placebo was defined by the upper limit of the 2-sided 95% CI for the hazard ratio (HR) of linagliptin relative to placebo being less than 1.3. Secondary outcome was time to first occurrence of adjudicated death due to renal failure, ESRD, or sustained 40% or higher decrease in eGFR from baseline. RESULTS Of 6991 enrollees, 6979 (mean age, 65.9 years; eGFR, 54.6 mL/min/1.73m2; 80.1% with UACR > 30mg/g) received at least 1 dose of study medication and 98.7% completed the study. During a median follow-up of 2.2 years, the primary outcome occurred in 434 of 3494 (12.4%) and 420 of 3485 (12.1%) in the linagliptin and placebo groups, respectively, (absolute incidence rate difference, 0.13 [95% CI,-0.63 to 0.90] per 100 person-years) (HR, 1.02; 95% CI, 0.89-1.17; P
- Published
- 2019
50. Aerogel Blanket Insulation Materials for Cryogenic Applications
- Author
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Coffman, B. E, Fesmire, J. E, White, S, Gould, G, and Augustynowicz, S
- Subjects
Composite Materials - Abstract
Aerogel blanket materials for use in thermal insulation systems are now commercially available and implemented by industry. Prototype aerogel blanket materials were presented at the Cryogenic Engineering Conference in 1997 and by 2004 had progressed to full commercial production by Aspen Aerogels. Today, this new technology material is providing superior energy efficiencies and enabling new design approaches for more cost effective cryogenic systems. Aerogel processing technology and methods are continuing to improve, offering a tailor-able array of product formulations for many different thermal and environmental requirements. Many different varieties and combinations of aerogel blankets have been characterized using insulation test cryostats at the Cryogenics Test Laboratory of NASA Kennedy Space Center. Detailed thermal conductivity data for a select group of materials are presented for engineering use. Heat transfer evaluations for the entire vacuum pressure range, including ambient conditions, are given. Examples of current cryogenic applications of aerogel blanket insulation are also given. KEYWORDS: Cryogenic tanks, thermal insulation, composite materials, aerogel, thermal conductivity, liquid nitrogen boil-off
- Published
- 2009
Catalog
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