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5. Ethanol inhibits dopamine uptake via organic cation transporter 3:Implications for ethanol and cocaine co-abuse

Author

Clauss, N. J., Mayer, F. P., Owens, W. A., Vitela, M., Clarke, K. M., Bowman, M. A., Horton, R. E., Gründemann, D., Schmid, D., Holy, M., Gould, G. G., Koek, W., Sitte, H. H., Daws, L. C., Clauss, N. J., Mayer, F. P., Owens, W. A., Vitela, M., Clarke, K. M., Bowman, M. A., Horton, R. E., Gründemann, D., Schmid, D., Holy, M., Gould, G. G., Koek, W., Sitte, H. H., and Daws, L. C.

Abstract

Concurrent cocaine and alcohol use is among the most frequent drug combination, and among the most dangerous in terms of deleterious outcomes. Cocaine increases extracellular monoamines by blocking dopamine (DA), norepinephrine (NE) and serotonin (5-HT) transporters (DAT, NET and SERT, respectively). Likewise, ethanol also increases extracellular monoamines, however evidence suggests that ethanol does so independently of DAT, NET and SERT. Organic cation transporter 3 (OCT3) is an emergent key player in the regulation of monoamine signaling. Using a battery of in vitro, in vivo electrochemical, and behavioral approaches, as well as wild-type and constitutive OCT3 knockout mice, we show that ethanol’s actions to inhibit monoamine uptake are dependent on OCT3. These findings provide a novel mechanistic basis whereby ethanol enhances the neurochemical and behavioral effects of cocaine and encourage further research into OCT3 as a target for therapeutic intervention in the treatment of ethanol and ethanol/cocaine use disorders., Concurrent cocaine and alcohol use is among the most frequent drug combination, and among the most dangerous in terms of deleterious outcomes. Cocaine increases extracellular monoamines by blocking dopamine (DA), norepinephrine (NE) and serotonin (5-HT) transporters (DAT, NET and SERT, respectively). Likewise, ethanol also increases extracellular monoamines, however evidence suggests that ethanol does so independently of DAT, NET and SERT. Organic cation transporter 3 (OCT3) is an emergent key player in the regulation of monoamine signaling. Using a battery of in vitro, in vivo electrochemical, and behavioral approaches, as well as wild-type and constitutive OCT3 knockout mice, we show that ethanol’s actions to inhibit monoamine uptake are dependent on OCT3. These findings provide a novel mechanistic basis whereby ethanol enhances the neurochemical and behavioral effects of cocaine and encourage further research into OCT3 as a target for therapeutic intervention in the treatment of ethanol and ethanol/cocaine use disorders.

Published
2023

7. Sulfite

Author

Gould, G. W., Russell, N. J., Russell, N. J., editor, and Gould, Grahame W., editor

Published
2003
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14. The S-Matrix Method

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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15. Lehmann-Symanzik-Zimmermann Formalism

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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17. Haag-Ruelle Scattering Theory

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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19. Fields in an Indefinite Metric

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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20. The Wightman Formalism

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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21. Algebra of Observables and State Space

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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22. The Jost-Lehmann-Dyson Representation

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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23. Relativistic Invariance in Quantum Theory

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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24. Analytic Functions of Several Complex Variables

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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25. Lorentz-Covariant Generalized Functions

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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26. The Technique of Generalized Functions

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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27. Preliminaries on Functional Analysis

Author

Bogolubov, N. N., Logunov, A. A., Oksak, A. I., Todorov, I. T., Gould, G. G., Flato, M., editor, Rączka, R., editor, Bogolubov, N. N., editor, Logunov, A. A., editor, Oksak, A. I., editor, and Todorov, I. T., editor

Published
1990
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28. EXPLORANDO DIFERENTES RECURSOS DIDÁTICOS NO ENSINO FUNDAMENTAL: UMA PROPOSTA PARA O ENSINO DE CÉLULA.

Author

Menglynn MCKERAL-GOULD, G. Lily, Lima RIBEIRO, Charles, Pereira LEMOS, Bruno, and Rodrigues CALDEIRA, Andreia Juliana

Abstract

Copyright of Revista Agrotecnologia is the property of Universidade Estadual de Goias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

34. Building an Indigenous-Led Evidence Base for Smoking Cessation Care among Aboriginal and Torres Strait Islander Women during Pregnancy and Beyond: Research Protocol for the Which Way? Project

Author

Bovill, M, Chamberlain, C, Bennett, J, Longbottom, H, Bacon, S, Field, B, Hussein, P, Berwick, R, Gould, G, O'Mara, P, Bovill, M, Chamberlain, C, Bennett, J, Longbottom, H, Bacon, S, Field, B, Hussein, P, Berwick, R, Gould, G, and O'Mara, P

Abstract

Strong and healthy futures for Aboriginal and Torres Strait Islander people requires engagement in meaningful decision making which is supported by evidence-based approaches. While a significant number of research publications state the research is co-designed, few describe the research process in relation to Indigenous ethical values. Improving the health and wellbeing of Aboriginal and Torres Strait Islander mothers and babies is crucial to the continuation of the oldest living culture in the world. Developing meaningful supports to empower Aboriginal and Torres Strait Islander mothers to quit smoking during pregnancy is paramount to addressing a range of health and wellbeing outcomes. Aboriginal and Torres Strait Islander women have called for non-pharmacological approaches to smoking cessation during pregnancy. We describe a culturally responsive research protocol that has been co-designed and is co-owned with urban and regional Aboriginal communities in New South Wales. The project has been developed in line with the AH&MRC's (Aboriginal Health & Medical Research Council) updated guidelines for ethical research with Aboriginal and Torres Strait Islander communities. Ethics approvals have been granted by AH&MRC #14541662 University of Newcastle HREC H-2020-0092 and the Local Health District ethics committee 2020/ETH02095. Results will be disseminated through peer reviewed articles, community reports, infographics, and online social media content.

Published
2021

40. Antibody Expression and Engineering

Author

HENRY Y. WANG, TADAYUKI IMANAKA, D. K. Robinson, D. DiStefano, S. L. Gould, G. Cuca, T. C. Seamans, D. Benincasa, S. Munshi, C. P. Chan, J. Stafford-Hollis, G. F. Hollis, D. Jain, K. Ramasubramanyan, G. E. Mark, M. Siberklang, Hidekazu Sawada, Kazuaki Kitano, R. S. Barnett, K. L. Limoli, T. B. Huynh, E. A. Ople, M. E. Re, Henry Y. Wang, Tadayuki Imanaka

Published
1995

47. Aerogel Blanket Insulation Materials for Cryogenic Applications

Author

Coffman, B. E, Fesmire, J. E, White, S, Gould, G, and Augustynowicz, S

Subjects
Composite Materials
Abstract

Aerogel blanket materials for use in thermal insulation systems are now commercially available and implemented by industry. Prototype aerogel blanket materials were presented at the Cryogenic Engineering Conference in 1997 and by 2004 had progressed to full commercial production by Aspen Aerogels. Today, this new technology material is providing superior energy efficiencies and enabling new design approaches for more cost effective cryogenic systems. Aerogel processing technology and methods are continuing to improve, offering a tailor-able array of product formulations for many different thermal and environmental requirements. Many different varieties and combinations of aerogel blankets have been characterized using insulation test cryostats at the Cryogenics Test Laboratory of NASA Kennedy Space Center. Detailed thermal conductivity data for a select group of materials are presented for engineering use. Heat transfer evaluations for the entire vacuum pressure range, including ambient conditions, are given. Examples of current cryogenic applications of aerogel blanket insulation are also given. KEYWORDS: Cryogenic tanks, thermal insulation, composite materials, aerogel, thermal conductivity, liquid nitrogen boil-off

Published
2009

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