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17 results on '"Gounot, Romain"'

1. Pregnancy in primary immunodeficiency diseases: The PREPI study

Author

Amazzough, Karima, Bertrand, Yves, Boutboul, David, Catherinot, Émilie, Chandesris, Olivia, Cheminant, Morgane, Couderc, Anne, D’Aveni, Maud, Delarue, Richard, Fieschi, Claire, Frenzel, Laurent, Galicier, Lionel, Gardembas, Martine, Goujard, Cécile, Gounot, Romain, Hermine, Olivier, Jaccard, Arnaud, Lambotte, Olivier, Lanternier, Fanny, Levy, Romain, Malphettes, Marion, Marcais, Ambroise, Mouthon, Luc, Oksenhendler, Eric, Perlat, Antoinette, Picard, Capucine, Queyrel, Viviane, Robin, Maris, Suarez, Felipe, Viallard, Jean François, Mallart, Elise, Françoise, Ugo, Driessen, Marine, Blanche, Stéphane, Lortholary, Olivier, Lefort, Agnès, Caseris, Marion, Fischer, Alain, Mahlaoui, Nizar, and Charlier, Caroline

Published
2023
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2. Changes in amyloidosis phenotype over 11 years in a cardiac amyloidosis referral centre cohort in France

Author

Damy, Thibaud, Zaroui, Amira, de Tournemire, Marie, Kharoubi, Mounira, Gounot, Romain, Galat, Arnault, Guendouz, Soulef, Funalot, Benoit, Itti, Emmanuel, Roulin, Louise, Audard, Vincent, Fanen, Pascale, Leroy, Vincent, Poulot, Elsa, Belhadj, Karim, Mallet, Sophie, Deep Singh Chadah, Gagan, Planté-Bordeneuve, Violaine, Gendre, Thierry, Chevalier, Xavier, Guignard, Sandra, Bequignon, Emilie, Bartier, Sophie, Folliguet, Thierry, Lemonier, François, Audureau, Etienne, Tixier, Denis, Canoui-Poitrine, Florence, Lefaucheur, Jean-Pascal, Souvannanorath, Sarah, Authier, Francois-Jerome, Maupou, Steven, Hittinger, Luc, Molinier-Frenkel, Valérie, David, Jean-Philippe, Broussier, Amaury, Oghina, Silvia, and Teiger, Emmanuel

Published
2023
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3. Prognostic mortality factors in advanced light chain cardiac amyloidosis: A prospective cohort study

Author

Zaroui, Amira, primary, Kharoubi, Mounira, additional, Gounot, Romain, additional, Oghina, Silvia, additional, Degoutte, Charlotte, additional, Bezard, Melanie, additional, Galat, Arnault, additional, Guendouz, Soulef, additional, Roulin, Louise, additional, Audard, Vincent, additional, Leroy, Vincent, additional, Teiger, Emmanuel, additional, Poullot, Elsa, additional, Molinier‐Frenkel, Valérie, additional, Le Bras, Fabien, additional, Belhadj, Karim, additional, Bastard, Jean‐Philippe, additional, Fellahi, Soraya, additional, Shourick, Jason, additional, Lemonier, Francois, additional, and Damy, Thibaud, additional

Published
2024
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4. Rate and characteristics of inflammatory neuropathies associated with brentuximab vedotin therapy.

Author

Matthys, Arthur, Bardel, Benjamin, Le Bras, Fabien, Créange, Alain, Nordine, Tarik, Gounot, Romain, Ingen‐Housz‐Oro, Saskia, Carvalho, Muriel, Lefaucheur, Jean‐Pascal, Haioun, Corinne, Planté‐Bordeneuve, Violaine, and Gendre, Thierry

Subjects
POLYNEUROPATHIES, CHRONIC inflammatory demyelinating polyradiculoneuropathy, PERIPHERAL neuropathy, MUSCLE weakness, GAIT disorders, PERIPHERAL nervous system
Abstract

Background and purpose: Peripheral neuropathy is a frequent complication of brentuximab vedotin (BV), used in CD30+ lymphoma treatment. Classic BV‐induced neuropathy (BV‐CN) is a mild distal sensory axonal polyneuropathy. Severe BV‐induced inflammatory neuropathies (BV‐IN) have been described. BV‐IN contribute to lymphoma‐associated morbidity but might be immunotherapy‐responsive. Our primary objective was to evaluate the rate of BV‐IN. Our secondary objectives were to determine risk factors and warning signs. Methods: We conducted a retrospective cohort study on all patients treated with BV at our center between April 2014 and September 2021. Clinical, biological, and electrophysiological data were collected. BV‐induced neuropathy was defined as the occurrence of neuropathy up to 3 months after BV discontinuation. BV‐IN was defined with criteria adapted from European Academy of Neurology/Peripheral Nerve Society 2021 electrodiagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy. Other neuropathies were classified as BV‐CN. Results: Among 83 patients, 41 (49%) developed neuropathy: 35 BV‐CN and 6 BV‐IN. Thus, the rate of BV‐IN was 7.2%. Compared to patients with BV‐CN, no predisposing factor was identified. However, patients with BV‐IN more frequently presented muscle weakness (67% vs. 5.7%, p < 0.05), gait disorders (83% vs. 20%, p < 0.05), or acute or subacute onset (67% vs. 14%, p < 0.05). BV‐IN was frequently more severe (Common Terminology Criteria for Adverse Events grade ≥3; 50% vs. 0%, p < 0.05). Four patients were treated with immunotherapy. Conclusions: Brentuximab vedotin‐induced neuropathy is an overlooked complication. Based on four easily identifiable "red flags", we provide an algorithm to help non‐neurologist physicians that care for BV‐treated patients to detect BV‐IN. The aim of the algorithm is to decrease the diagnostic and management delay of this disabling neuropathy. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Teclistamab in relapsed or refractory AL amyloidosis: a multinational retrospective case series

Author

Forgeard, Nathalie, primary, Elessa, Dikélélé, additional, Carpinteiro, Alexander, additional, Belhadj, Karim, additional, Minnema, Monique, additional, Roussel, Murielle, additional, Huart, Antoine, additional, Javaugue, Vincent, additional, Pascal, Laurent, additional, Royer, Bruno, additional, Talbot, Alexis, additional, Gounot, Romain, additional, Hegenbart, Ute, additional, Schonland, Stefan, additional, Karlin, Lionel, additional, Harel, Stéphanie, additional, Kastritis, Efstathios, additional, Bridoux, Frank, additional, Jaccard, Arnaud, additional, and Arnulf, Bertrand, additional

Published
2024
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6. Efficacy of CAR T-cell therapy is not impaired by previous bispecific antibody treatment in large B-cell lymphoma

Author

Crochet, Gilles, Iacoboni, Gloria, Couturier, Audrey, Bachy, Emmanuel, Iraola-Truchuelo, Josu, Gastinne, Thomas, Cartron, Guillaume, Fradon, Tom, Lesne, Bastien, Kwon, Mi, Gounot, Romain, Martínez-Cibrian, Nuria, Castilla-Llorente, Cristina, Abrisqueta, Pau, Guerreiro, Manuel, Sarkozy, Clémentine, Aspa-Cilleruelo, Jose María, Camus, Vincent, Guidez, Stéphanie, Chauchet, Adrien, Deconinck, Eric, Bouabdallah, Krimo, Bosch, Francesc, Barba, Pere, Morschhauser, Franck, and Houot, Roch

Published
2024
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7. Amylo-AFFECT-QOL, a self-reported questionnaire to assess health-related quality of life and to determine the prognosis in cardiac amyloidosis

Author

Kharoubi, Mounira, primary, Bézard, Mélanie, additional, Broussier, Amaury, additional, Galat, Arnault, additional, Gounot, Romain, additional, Poullot, Elsa, additional, Molinier-Frenkel, Valérie, additional, Fanen, Pascale, additional, Funalot, Benoit, additional, Itti, Emmanuel, additional, Lemonnier, François, additional, Sing Chadha, Gagan Deep, additional, Guendouz, Soulef, additional, Mallet, Sophie, additional, Zaroui, Amira, additional, Audard, Vincent, additional, Audureau, Etienne, additional, Le Corvoisier, Philippe, additional, Hittinger, Luc, additional, Planté Bordeneuve, Violaine, additional, Lefaucheur, Jean-Pascal, additional, Amiot, Aurélien, additional, Bequignon, Emilie, additional, Bartier, Sophie, additional, Leroy, Vincent, additional, Teiger, Emmanuel, additional, Oghina, Silvia, additional, and Damy, Thibaud, additional

Published
2023
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8. CAR T-Cell Therapy Remain Effective in Patients with Relapse/Refractory B-Cell Non-Hodgkin Lymphoma after Bispecific Antibodies Exposure: Results of a Lysa Study Based on the Descar-T Registry

Author

Crochet, Gilles, primary, Audrey, Couturier, additional, Bachy, Emmanuel, additional, Gastinne, Thomas, additional, Cartron, Guillaume, additional, Fradon, Tom, additional, Gounot, Romain, additional, Castilla-LLorente, Cristina, additional, Sarkozy, Clementine, additional, Camus, Vincent, additional, Guidez, Stéphanie, additional, Chauchet, Adrien, additional, Deconinck, Eric, additional, Bouabdallah, Krimo, additional, Morschhauser, Franck, additional, and Houot, Roch, additional

Published
2022
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9. Anti-SARS-CoV-2 antibody response after 2 and 3 doses of BNT162b2 mRNA vaccine in patients with lymphoid malignancies

Author

Gressens, Simon B., primary, Fourati, Slim, additional, Le Bouter, Anne, additional, Le Bras, Fabien, additional, Dupuis, Jehan, additional, Hammoud, Mohammad, additional, El Gnaoui, Taoufik, additional, Gounot, Romain, additional, Roulin, Louise, additional, Belhadj, Karim, additional, Haioun, Corinne, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, and Lemonnier, François, additional

Published
2022
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11. Integrative Study of a High-Grade B-Cell Lymphoma Cohort of 45 Patients: A Single Institution Real Life Study

Author

Roulin, Louise, primary, Poullot, Elsa, additional, Blanc-Durand, Paul, additional, Robe, Cyrielle, additional, Lemonnier, Francois, additional, Le Bras, Fabien, additional, Gounot, Romain, additional, Belhadj, Karim, additional, Dupuis, Jehan, additional, Hammoud, Mohammad, additional, El Gnaoui, Taoufik, additional, Mule, Sebastien, additional, Copie Bergman, Christiane, additional, Molina, Thierry, additional, Delfau Larue, Marie Helene, additional, Itti, Emmanuel, additional, Gaulard, Philippe, additional, and Haioun, Corinne, additional

Published
2021
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12. Efficacy of Chimeric Antigen Receptor T-Cell Therapy Is Not Impaired By Previous Bispecific Antibody Treatment in Patients with Large B-Cell Lymphoma

Author

Iacoboni, Gloria, Crochet, Gilles, Couturier, Audrey, Bachy, Emmanuel, Iraola, Josu, Gastinne, Thomas, Herbaux, Charles, Fradon, Tom, Kwon, Mi, Gounot, Romain, Martinez-Cibrian, Nuria, Castilla-Llorente, Cristina, Guerreiro, Manuel, Sarkozy, Clementine, Aspa-Cilleruelo, Jose, Camus, Vincent, Guidez, Stephanie, Chauchet, Adrien, Deconinck, Eric, Bouabdallah, Krimo, Barba, Pere, Houot, Roch, and Morschhauser, Franck

Published
2023
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13. Venetoclax induces profound and sustained responses in patients with relapsed/refractory light‐chain amyloidosis

Author

Pasquer, Hélène, primary, Belhadj, Karim, additional, Dupuis, Jehan, additional, Oghina, Sylvia, additional, Galat, Antoine, additional, Ladaique, Amandine, additional, Maarek, Alizée, additional, Roulin, Louise, additional, Gounot, Romain, additional, Poulot, Elsa, additional, Beldi‐Ferchiou, Asma, additional, Molinier‐Frenkel, Valérie, additional, Haioun, Corinne, additional, Damy, Thibaud, additional, Le Bras, Fabien, additional, and Lemonnier, François, additional

Published
2021
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14. Daratumumab is safe and induces a rapid hematological response in light-chain amyloidosis with severe cardiac impairment

Author

Gounot, Romain, primary, Le Bras, Fabien, additional, Dupuis, Jehan, additional, Oghina, Silvia, additional, Bodez, Diane, additional, Roulin, Louise, additional, Maarek, Alizee, additional, Ladaique, Amandine, additional, Beldi-Ferchiou, Asma, additional, Poullot, Elsa, additional, Molinier-Frenkel, Valerie, additional, Haioun, Corinne, additional, Damy, Thibaud, additional, Belhadj, Karim, additional, and Lemonnier, François, additional

Published
2020
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15. Daratumumab is safe and induces a rapid hematological response in light-chain amyloidosis with severe cardiac impairment.

Author

Gounot, Romain, Le Bras, Fabien, Dupuis, Jehan, Oghina, Silvia, Bodez, Diane, Roulin, Louise, Maarek, Alizee, Ladaique, Amandine, Beldi-Ferchiou, Asma, Poullot, Elsa, Molinier-Frenkel, Valerie, Haioun, Corinne, Damy, Thibaud, Belhadj, Karim, and Lemonnier, François

Subjects
*CARDIAC amyloidosis, *URINARY tract infections, *PLASMA cell diseases
Abstract

Eighteen patients received a dose of 20 mg at each daratumumab infusions, three patients received 10 mg and four patients did not receive dexamethasone because of dexamethasone induced cardiac failure. Systemic light-chain (AL) amyloidosis is a plasma cell disorder characterized by extracellular deposition of monoclonal immunoglobulin light chains leading to organ dysfunction. We assessed the efficacy of daratumumab in such AL patients with severe cardiac involvement by performing a single-center retrospective study that included consecutive patients with Mayo Clinic stage III AL treated with daratumumab from May 2017 to August 2019. However, patients with severe cardiac amyloidosis involvement, defined as stage IIIb by the Mayo classification with European modification, have been excluded from these studies and little data on daratumumab use are available for patients with severe cardiac involvement. [Extracted from the article]

Published
2021
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16. CAR T-cells in very elderly (≥80 years) lymphoma patients: a DESCAR-T analysis.

Author

Menez, Simon, Bourbon, Estelle, Gounot, Romain, Tudesq, Jean-Jacques, Moya, Niels, Houot, Roch, and Bachy, Emmanuel

Subjects
*HEMATOPOIETIC stem cell transplantation, *B cell lymphoma, *MANTLE cell lymphoma, *CYTOKINE release syndrome, *OLDER patients
Abstract

This document is a letter to the editor discussing the use of CAR T-cell therapy in elderly lymphoma patients aged 80 years and older. The authors report on the outcomes of 12 patients who received CAR T-cell therapy and found that it was feasible and provided some clinical benefit, although efficacy outcomes were slightly lower compared to previous studies. Adverse events were reported, but no severe events occurred. The study suggests that CAR T-cell therapy may be beneficial for selected elderly patients with lymphoma, but more research is needed to confirm these results. [Extracted from the article]

Published
2024
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17. Teclistamab in relapsed or refractory AL amyloidosis: a multinational retrospective case series

Author

Forgeard, Nathalie, Elessa, Dikélélé, Carpinteiro, Alexander, Belhadj, Karim, Minnema, Monique, Roussel, Murielle, Huart, Antoine, Javaugue, Vincent, Laurent, Pascal, Royer, Bruno, Talbot, Alexis, Gounot, Romain, Hegenbart, Ute, Schonland, Stefan, Karlin, Lionel, Harel, Stéphanie, Kastritis, Efstathios, Bridoux, Frank, Jaccard, Arnaud, and Arnulf, Bertrand

Published
2023
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