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26 results on '"Gourbeyre, Pascal"'

1. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity

Author

Régnier, Marion, Polizzi, Arnaud, Lukowicz, Céline, Smati, Sarra, Lasserre, Frédéric, Lippi, Yannick, Naylies, Claire, Laffitte, Joelle, Bétoulières, Colette, Montagner, Alexandra, Ducheix, Simon, Gourbeyre, Pascal, Ellero-Simatos, Sandrine, Menard, Sandrine, Bertrand-Michel, Justine, Al Saati, Talal, Lobaccaro, Jean-Marc, Burger, Hester M., Gelderblom, Wentzel C., Guillou, Hervé, Oswald, Isabelle P., and Loiseau, Nicolas

Published
2019
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3. Tissular Genomic Responses to Oral FB1 Exposure in Pigs

Author

Dopavogui, Léonie, primary, Polizzi, Arnaud, additional, Fougerat, Anne, additional, Gourbeyre, Pascal, additional, Terciolo, Chloé, additional, Klement, Wendy, additional, Pinton, Philippe, additional, Laffite, Joëlle, additional, Cossalter, Anne-Marie, additional, Bailly, Jean-Denis, additional, Puel, Olivier, additional, Lippi, Yannick, additional, Naylies, Claire, additional, Guillou, Hervé, additional, Oswald, Isabelle P., additional, and Loiseau, Nicolas, additional

Published
2022
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5. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity

Author

Régnier, Marion, primary, Polizzi, Arnaud, additional, Lukowicz, Céline, additional, Smati, Sarra, additional, Lasserre, Frédéric, additional, Lippi, Yannick, additional, Naylies, Claire, additional, Laffitte, Joelle, additional, Bétoulières, Colette, additional, Montagner, Alexandra, additional, Ducheix, Simon, additional, Gourbeyre, Pascal, additional, Ellero-Simatos, Sandrine, additional, Menard, Sandrine, additional, Bertrand-Michel, Justine, additional, Al Saati, Talal, additional, Lobaccaro, Jean-Marc, additional, Burger, Hester M., additional, Gelderblom, Wentzel C., additional, Guillou, Hervé, additional, Oswald, Isabelle P., additional, and Loiseau, Nicolas, additional

Published
2018
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6. Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine

Author

Régnier, Marion, primary, Gourbeyre, Pascal, additional, Pinton, Philippe, additional, Napper, Scott, additional, Laffite, Joëlle, additional, Cossalter, Anne‐Marie, additional, Bailly, Jean‐Denis, additional, Lippi, Yannick, additional, Bertrand‐Michel, Justine, additional, Bracarense, Ana Paula F.R.L., additional, Guillou, Hervé, additional, Loiseau, Nicolas, additional, and Oswald, Isabelle P., additional

Published
2017
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7. Previous food allergy aggravates allergic markers and intestinal damages in a mouse model of asthma

Author

Bouchaud, Gregory, Gourbeyre, Pascal, Bihouée, Tiphaine, Aubert, Philippe, Lair, David, Cheminant, Marie-Aude, Denery, Sandra, Neunlist, Michel, Magnan, Antoine, Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), International Cytokine and Interferon Society (ICIS). AUS., ProdInra, Migration, and Unité de recherche de l'institut du thorax (ITX-lab)

Subjects
food allergy, atopic march, mouse model, gut, lung, asthma, souris, respiratory tract diseases, Allergologie, asthme, Allergology, immune system diseases, poumon, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, allergie alimentaire, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology, dermatite atopique
Abstract

International audience; Increasing clinical data suggest a link between food allergy and the later development of respiratory allergy. This progression may be triggered by exposures to different allergens but the mechanism implicated remains unknown. This study aimed to identify the impact of a first exposure to food allergen on the development of a new form of allergy caused by exposure to a novel allergen using a mouse model.

Published
2014
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8. Les récepteurs aux éléments microbiens dans l'intestin : analyse de leur expression dans les différents segments et organes lymphoïdes et le long de l'axe crypto-villositaire

Author

Gourbeyre, Pascal, Berri, El Mostafa, Chevaleyre, Claire, Gaillard, Claire, Pinton, Philippe, Oswald, Isabelle, Toxicologie Alimentaire (UTA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, UR Infectiologie animale et Santé publique (UR IASP), Institut National de la Recherche Agronomique (INRA), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Toxicologie Alimentaire ( UTA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, UR Infectiologie animale et Santé publique ( UR IASP ), Institut National de la Recherche Agronomique ( INRA ), Génétique Animale et Biologie Intégrative ( GABI ), Institut National de la Recherche Agronomique ( INRA ) -AgroParisTech, ProdInra, Archive Ouverte, AgroParisTech-Institut National de la Recherche Agronomique (INRA), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Institut National de Recherche Agronomique (INRA). UAR Département Santé Animale (0564)., and Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)

Subjects
Lamina propria, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, TLR, Système immunitaire, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, NOD
Abstract

Session 3 : Dialogue agresseurs-hôtes, adaptation réciproquesCommunication orale; absent

Published
2013

9. Pattern recognition receptors are differentially expressed in the pig small intestine

Author

Gourbeyre, Pascal, Nassif, Charbel, Lippi, Yannick, Chevaleyre, Claire, Melo, Sandrina, Pinton, Philippe, Berri, El Mostafa, ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Transcriptomic impact of Xenobiotics (E23 TRiX), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), Istituto Zooprofilattico Sperimentale della Lombardia e dell' Emilia Romagna Bruno Ubertini. Brescia, ITA., Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Plateforme Génome & Transcriptome (GET), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
[SDV.BA]Life Sciences [q-bio]/Animal biology
Abstract

International audience; Pattern Recognition Receptors (PRR) include Toll-like receptors and NOD-like receptors. These molecules are involved in the innate immune response to infection, triggering inflammatory responses. The aim of this study was to determine if PRR and inflammatory cytokines are differentially expressed along the intestinal segments and relative lymphoid organs of healthy pigs. Duodenum, jejunum, ileum, jejunal Peyer patches, ileal Peyer patches and mesenteric lymph nodes were collected from 32 healthy pigs to study the expression of genes encoding for PRR (Tolllike receptors 1 to 10, NOD1 and NOD2) and inflammatory cytokines by quantitative PCR. Toll-like receptors 1, 2, 4, 5, 6, 8, 9, 10 were less expressed in the duodenum than in the other intestinal segments. Toll-like receptors 1, 2, 4, 7, 8, 9, 10, NOD1, 2 were more expressed in the mesenteric lymph nodes than in the intestinal segments. Toll-like receptors 1, 7, 8, 9, 10 showed a more pronounced expression in Peyer patches than in relative intestinal segment. A heatmap analysis of our data highlights two distinct clusters of organs. Intestinal segments belong to the first cluster. They displayed high expression levels of TLR 5, 6 and IL-1 beta. Among these segments, duodenum was characterized by a weak expression of PRRs and cytokines, which may be related to its local lumen environment, poor in microorganisms. Lymphoid organs belong to the second cluster. They showed weak expression levels of TLR3, 5 and IL-1 beta and a high expression of TLR 1, 2, 7, 9, 10, IL-6 and TNF-alpha. Among these organs, mesenteric lymph nodes presented a high expression of most PRR and inflammatory cytokines, which may be related to their antigen uptake function. Our findings demonstrate thus that PRR and cytokines are differentially expressed along the intestine, highlighting segment-specific mechanisms. Acknowledgment: The present study was supported by the ANR “Sus Flora” research grant (coordinator: Claire Rogel-Gaillard).

Published
2013

10. Study of immuno-physiological mechanism implicated in atopic march using an original mouse model of food and respiratory combined allergy

Author

Bouchaud, Gregory, Gourbeyre, Pascal, Bihouée-Roussey, T., Aubert, P., Lair, D., Denery-Papini, Sandra, Neunlist, M., Magnan, A., Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Cardiopathies et mort subite [ERL 3147], Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN), U913 neuropathies du système nerveux entérique et pathologies digestives, Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
[SDV.IDA]Life Sciences [q-bio]/Food engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

11. A first sensitisation to food allergen induces an aggravation of asthmatic phenotype in a house dust mite asthmatic model

Author

Lair, D., Roussey-Bihouée, T., Rolland-Debord, C., Aubert, P., Gourbeyre, Pascal, Cheminant, M.-A., Sagan, C., Neunlist, M., Bodinier, Marie, Magnan, A., ProdInra, Migration, Institut National de la Santé et de la Recherche Médicale (INSERM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), U913 neuropathies du système nerveux entérique et pathologies digestives, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.IDA]Life Sciences [q-bio]/Food engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.IDA] Life Sciences [q-bio]/Food engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

12. Impact of the exposure period to galactooligosaccharides/inulin prebiotics on immune system orientation

Author

Gourbeyre, Pascal, Desbuards, Nicolas, Grémy, Guilaine, Tranquet, Olivier, Champ, Martine, Denery-Papini, Sandra, Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Physiologie des Adaptations Nutritionnelles (PhAN), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)

Subjects
[SDV.IDA]Life Sciences [q-bio]/Food engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

13. Les prébiotiques : une stratégie pour lutter contre les allergies?

Author

Bodinier, Marie, Gourbeyre, Pascal, ProdInra, Migration, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)

Subjects
Allergie, [SDV.IMM] Life Sciences [q-bio]/Immunology, ORL, Immunopathologie, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2012

14. Prebiotics induce tolerance mechanisms but are not able to alleviate allergic symptoms in a mouse model of wheat allergy

Author

Gourbeyre, Pascal, Desbuards, Nicolas, Triballeau, Sylvie, Grémy, Guilaine, Champ, Martine, Denery-Papini, Sandra, Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Physiologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), and The European Academy of Allergy and Clinical Immunology (EAACI). Zurich, CHE. the Turkish National Society of Allergy and Clinical Immunology cordially.

Subjects
[SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

15. Des prébiotiques capables d’induire des mécanismes de tolérance sans réduire les symptômes d’allergie chez la souris

Author

Gourbeyre, Pascal, Desbuards, Nicolas, Triballeau, Sylvie, Grémy, Guilaine, Champ, Martine, Denery-Papini, Sandra, Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Physiologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), and Société Française d’Allergologie (SFA). FRA.

Subjects
systeme immunitaire, murin, prebiotique, nutrition prénatale, symptôme, prebiotiques, gos/inuline, prevention, allergie alimentaire, mécanismes, Allergologie, Allergology, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

16. Relations entre le microbiote intestinal et les allergies alimentaires

Author

Bodinier, Marie, Gourbeyre, Pascal, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
probiotiques, Microbiote intestina, [SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.IDA]Life Sciences [q-bio]/Food engineering, dysbiose, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.IDA] Life Sciences [q-bio]/Food engineering, prébiotiques, allergie alimentaire, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

17. Les prébiotiques peuvent-ils agir sur la maturation intestinale et prévenir du risque allergique alimentaire chez le nouveau-né ?'

Author

Gourbeyre, Pascal, Desbuards, Nicolas, Triballeau, Sylvie, Michel, Catherine, Champ, Martine, Denery-Papini, Sandra, Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Physiologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), and Réseau d'Intelligence Territoriale. Rennes, FRA.

Subjects
allergies, système immunitaire, prebiotique, prévention des maladies, nouveau né, GOS et inuline, mécanismes, Allergologie, prévention, maturation de l'intestin, Allergology, prébiotiques, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, allergie alimentaire, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

19. 14

Author

Bouchaud, Gregory, primary, Gourbeyre, Pascal, additional, Bihouee, Tiphaine, additional, Aubert, Philippe, additional, Lair, David, additional, Cheminant, Maire-Aude, additional, Denery, Sandra, additional, Neunlist, Michel, additional, Magnan, Antoine, additional, and Bodinier, Marie, additional

Published
2014
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26. Impact of perinatal prebiotic consumption on gestating mice and their offspring: a preliminary report.

Author

Desbuards, Nicolas, Gourbeyre, Pascal, Haure-Mirande, Vianney, Darmaun, Dominique, Champ, Martine, and Bodinier, Marie

Subjects
ANIMAL experimentation, BODY weight, DIETARY supplements, INFANT development, INFANT weaning, LONGITUDINAL method, MICE, PROBABILITY theory, PUERPERIUM, U-statistics, LEPTIN, FETAL development, PREBIOTICS, PREGNANCY
Abstract

To assess the impact of prebiotic supplementation during gestation and fetal and early neonatal life, gestating BALB/cj dam mice were fed either a control or a prebiotic (galacto-oligosaccharides–inulin, 9:1 ratio)-enriched diet throughout pregnancy and lactation, and allowed to nurse their pups until weaning. At the time of weaning, male offspring mice were separated from their mothers, weaned to the same solid diet as their dam and their growth was monitored until killed 48 d after weaning. Prebiotic treatment affected neither the body-weight gain nor the food intake of pregnant mice. In contrast, at the time of weaning, pups that had been nursed by prebiotic-fed dams had a higher body weight (11·0 (se 1·2) g) than pups born from control dams (9·8 (se 0·9) g). At 48 d after weaning, significantly higher values were observed for colon length and muscle mass in the offspring of prebiotic-fed dams (1·2 (se 0·1) cm/cm and 5·7 (se 1·8) mg/g, respectively), compared with control offspring (1·1 (se 0·1) cm/cm and 2·9 (se 0·9) mg/g, respectively), without any difference in spleen and stomach weight, or serum leptin concentration. The present preliminary study suggests that altering the fibre content of the maternal diet during both pregnancy and lactation enhances offspring growth, through an effect on intestinal and muscle mass rather than fat mass accretion. [ABSTRACT FROM PUBLISHER]

Published
2012
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