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23 results on '"Govaert, Marc"'

1. Cost-effectiveness of general practitioner- versus surgeon-led colon cancer survivorship care: an economic evaluation alongside a randomised controlled trial

Author

Vos, Julien A. M., El Alili, Mohamed, Duineveld, Laura A. M., Wieldraaijer, Thijs, Wind, Jan, Sert, Edanur, Donkervoort, Sandra C., Govaert, Marc J. P. M., van Geloven, Nanette A. W., van de Ven, Anthony W. H., Heuff, Gijsbert, van Weert, Henk C. P. M., Bosmans, Judith E., and van Asselt, Kristel M.

Published
2024
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2. Better stoma care using the Stoma App: does it help? A first randomized double-blind clinical trial on the effect of mobile healthcare on quality of life in stoma patients

Author

van der Storm, Sebastiaan L., Consten, Esther C. J., Govaert, Marc J. P. M., Tuynman, Jurriaan B., Oosterling, Steven J., Grotenhuis, Brechtje A., Smits, Anke B., Marsman, Hendrik A., van Rossem, Charles C., van Duyn, Eino B., de Nes, Lindsey C. F., Verdaasdonk, Emiel, de Vries Reilingh, Tammo S., Vening, Wouter, Bemelman, Willem A., and Schijven, Marlies P.

Published
2024
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3. Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment

Author

Aalbers, Arend G.J., van Aalten, Susanna M., Amelung, Femke J., Ankersmit, Marjolein, Antonisse, Imogeen E., Ashruf, Jesse F., Aukema, Tjeerd S., Avenarius, Henk, Bahadoer, Renu R., Bakers, Frans C.H., Bakker, Ilsalien S., Bangert, Fleur, Barendse, Renée M., Beekhuis, Heleen M.D., Beets, Geerard L., Bemelman, Willem A., Berbée, Maaike, de Bie, Shira H., Bisschops, Robert H.C., Blok, Robin D., van Bockel, Liselotte W., Boer, Anniek H., den Boer, Frank C., Boerma, Evert-Jan G., Boogerd, Leonora S.F., Borstlap, Jaap, Borstlap, Wernard A.A., Bouwman, Johanna E., Braak, Sicco J., Braat, Manon N.G.J.A., Bradshaw, Jennifer, Brandsma, Amarins T.A., van Breest Smallenburg, Vivian, van den Broek, Wim T., van der Burg, Sjirk W., Burger, Jacobus W.A., Burghgraef, Thijs A., ten Cate, David W.G., Ceha, Heleen M., Cnossen, Jeltsje S., Coebergh van den Braak, Robert R.J., Consten, Esther C.J., Corver, Maaike, Crolla, Rogier M.P.H., Curutchet, Sam, Daniëls-Gooszen, Alette W., Davids, Paul H.P., Dekker, Emmelie N., Dekker, Jan Willem T., Demirkiran, Ahmet, Derksen, Tyche, Diederik, Arjen L., Dinaux, Anne M., Dogan, Kemal, van Dop, Ilse M., Droogh-de Greve, Kitty E., Duijsens, Hanneke M.H., Dunker, Michalda S., Duyck, Johan, van Duyn, Eino B., van Egdom, Laurentine S.E., Eijlers, Bram, El-Massoudi, Youssef, van Elderen, Saskia, Emmen, Anouk M.L.H., Engelbrecht, Marc, van Erp, Anne C., van Essen, Jeroen A., Fabry, Hans F.J., Fassaert, Thomas, Feitsma, Eline A., Feshtali, Shirin S., Frietman, Bas, Furnée, Edgar J.B., van Geel, Anne M., Geijsen, Elisabeth D., van Geloven, Anna A.W., Gerhards, Michael F., Gielkens, Hugo, van Gils, Renza A.H., Goense, Lucas, Govaert, Marc J.P.M., van Grevenstein, Wilhelmina M.U., Joline de Groof, E., de Groot, Irene, de Haas, Robbert J., Hakkenbrak, Nadia A.G., den Hartogh, Mariska D., Heesink, Vera, Heikens, Joost T., Hendriksen, Ellen M., van den Hoek, Sjoerd, van der Hoeven, Erik J.R.J., Hoff, Christiaan, Hogewoning, Anna, Hogewoning, Cornelis R.C., Hoogendoorn, Stefan, van Hoorn, Francois, van der Hul, René L., van Hulst, Rieke, Imani, Farshad, Inberg, Bas, Intven, Martijn P.W., Janssen, Pedro, de Jong, Chris E.J., Jonkers, Jacoline, Jou-Valencia, Daniela, Keizers, Bas, Ketelaers, Stijn H.J., Knöps, Eva, van Koeverden, Sebastiaan, Kok, Sylvia, Kolderman, Stephanie E.M., de Korte, Fleur I., Kortekaas, Robert T.J., Korving, Julie C., Koster, Ingrid M., Krdzalic, Jasenko, Krielen, Pepijn, Kroese, Leonard F., Krul, Eveline J.T., Lahuis, Derk H.H., Lamme, Bas, van Landeghem, An A.G., Leijtens, Jeroen W.A., Leseman-Hoogenboom, Mathilde M., de Lijster, Manou S., Marsman, Martijn S., Martens, MilouH., Masselink, Ilse, van der Meij, Wout, Meijnen, Philip, Melenhorst, Jarno, de Mey, Dietrich J.L., Moelker-Galuzina, Julia, Morsink, Linda, Mulder, Erik J., Muller, Karin, Musters, Gijsbert D., Neijenhuis, Peter A., de Nes, Lindsey C.F., Nielen, M., van den Nieuwboer, Jan B.J., Nieuwenhuis, Jonanne F., Nonner, Joost, Noordman, Bo J., Nordkamp, Stefi, Olthof, Pim B., Oosterling, Steven J., Ootes, Daan, Oppedijk, Vera, Ott, Pieter, Paulusma, Ida, Peeters, Koen C.M.J., Pereboom, Ilona T.A., Peringa, Jan, Pironet, Zoë, Plate, Joost D.J., Polat, Fatih, Poodt, Ingrid G.M., Posma, Lisanne A.E., Prette, Jeroen F., Pultrum, Bareld B., Qaderi, Seyed M., van Rees, Jan M., Renger, Rutger-Jan, Rombouts, Anouk J.M., Roosen, Lodewijk J., Roskott-ten Brinke, Ellen A., Rothbarth, Joost, Rouw, Dennis B., Rozema, Tom, Rütten, Heidi, Rutten, Harm J.T., van der Sande, Marit E., Schaafsma, Boudewijn E., Schasfoort, Renske A., Scheurkogel, Merel M., Schouten van der Velden, Arjan P., Schreurs, Wilhelmina H., Schuivens, Puck M.E., Sietses, Colin, Simons, Petra C.G., Slob, Marjan J., Slooter, Gerrit D., van der Sluis, Martsje, Smalbroek, Bo P., Smits, Anke B., Spillenaar-Bilgen, Ernst J., Spruit, Patty H., Stam, Tanja C., Stoker, Jaap, Talsma, Aaldert K., Temmink, Sofieke J.D., The, G.Y. Mireille, Tielbeek, Jeroen A.W., van Tilborg, Aukje A.J.M., van Tilborg, Fiek, van Trier, Dorothée, Tuynman, Jurriaan B., van der Valk, Maxime J.M., Vanhooymissen, Inge J.S., Vasbinder, G. Boudewijn C., Veeken, Cornelis J., Velema, Laura A., van de Ven, Anthony W.H., Verdaasdonk, Emiel G.G., Verduin, Wouter M., Verhagen, Tim, Verheijen, Paul M., Vermaas, Maarten, Verrijssen, An-Sofie E., Verschuur, Anna V.D., Schaik, Harmke Verwoerd-van, Vliegen, Roy F.A., Voets, Sophie, Vogelaar, F. Jeroen, Vogelij, Clementine L.A., Vos-Westerman, Johanna, de Vries, Marianne, Vroemen, Joy C., van Vugt, Bas S.T., Wegdam, Johannes A., van Wely, Bob J., Westerterp, Marinke, van Westerveld, Paul P., van Westreenen, Henderik L., Wijma, Allard G., de Wilt, Johannes H.W., de Wit, Bart W.K., Wit, Fennie, Woensdregt, Karlijn, van Woerden, Victor, van der Wolf, Floor S.W., van der Wolk, Sander, Wybenga, Johannes M., van der Zaag, Edwin S., Zamaray, Bobby, Zandvoort, Herman J.A., van der Zee, Dennis, Zeilstra, Annette P., Zheng, Kang J., Zimmerman, David D.E., Zorgdrager, Marcel, Geffen, Eline G.M. van, Nederend, Joost, Sluckin, Tania C., Hazen, Sanne-Marije J.A., Horsthuis, Karin, Beets-Tan, Regina G.H., Marijnen, Corrie A.M., Tanis, Pieter J., and Kusters, Miranda

Published
2024
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4. Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment

Author

Geffen, Eline G.M. van, primary, Nederend, Joost, additional, Sluckin, Tania C., additional, Hazen, Sanne-Marije J.A., additional, Horsthuis, Karin, additional, Beets-Tan, Regina G.H., additional, Marijnen, Corrie A.M., additional, Tanis, Pieter J., additional, Kusters, Miranda, additional, Aalbers, Arend G.J., additional, van Aalten, Susanna M., additional, Amelung, Femke J., additional, Ankersmit, Marjolein, additional, Antonisse, Imogeen E., additional, Ashruf, Jesse F., additional, Aukema, Tjeerd S., additional, Avenarius, Henk, additional, Bahadoer, Renu R., additional, Bakers, Frans C.H., additional, Bakker, Ilsalien S., additional, Bangert, Fleur, additional, Barendse, Renée M., additional, Beekhuis, Heleen M.D., additional, Beets, Geerard L., additional, Bemelman, Willem A., additional, Berbée, Maaike, additional, de Bie, Shira H., additional, Bisschops, Robert H.C., additional, Blok, Robin D., additional, van Bockel, Liselotte W., additional, Boer, Anniek H., additional, den Boer, Frank C., additional, Boerma, Evert-Jan G., additional, Boogerd, Leonora S.F., additional, Borstlap, Jaap, additional, Borstlap, Wernard A.A., additional, Bouwman, Johanna E., additional, Braak, Sicco J., additional, Braat, Manon N.G.J.A., additional, Bradshaw, Jennifer, additional, Brandsma, Amarins T.A., additional, van Breest Smallenburg, Vivian, additional, van den Broek, Wim T., additional, van der Burg, Sjirk W., additional, Burger, Jacobus W.A., additional, Burghgraef, Thijs A., additional, ten Cate, David W.G., additional, Ceha, Heleen M., additional, Cnossen, Jeltsje S., additional, Coebergh van den Braak, Robert R.J., additional, Consten, Esther C.J., additional, Corver, Maaike, additional, Crolla, Rogier M.P.H., additional, Curutchet, Sam, additional, Daniëls-Gooszen, Alette W., additional, Davids, Paul H.P., additional, Dekker, Emmelie N., additional, Dekker, Jan Willem T., additional, Demirkiran, Ahmet, additional, Derksen, Tyche, additional, Diederik, Arjen L., additional, Dinaux, Anne M., additional, Dogan, Kemal, additional, van Dop, Ilse M., additional, Droogh-de Greve, Kitty E., additional, Duijsens, Hanneke M.H., additional, Dunker, Michalda S., additional, Duyck, Johan, additional, van Duyn, Eino B., additional, van Egdom, Laurentine S.E., additional, Eijlers, Bram, additional, El-Massoudi, Youssef, additional, van Elderen, Saskia, additional, Emmen, Anouk M.L.H., additional, Engelbrecht, Marc, additional, van Erp, Anne C., additional, van Essen, Jeroen A., additional, Fabry, Hans F.J., additional, Fassaert, Thomas, additional, Feitsma, Eline A., additional, Feshtali, Shirin S., additional, Frietman, Bas, additional, Furnée, Edgar J.B., additional, van Geel, Anne M., additional, Geijsen, Elisabeth D., additional, van Geloven, Anna A.W., additional, Gerhards, Michael F., additional, Gielkens, Hugo, additional, van Gils, Renza A.H., additional, Goense, Lucas, additional, Govaert, Marc J.P.M., additional, van Grevenstein, Wilhelmina M.U., additional, Joline de Groof, E., additional, de Groot, Irene, additional, de Haas, Robbert J., additional, Hakkenbrak, Nadia A.G., additional, den Hartogh, Mariska D., additional, Heesink, Vera, additional, Heikens, Joost T., additional, Hendriksen, Ellen M., additional, van den Hoek, Sjoerd, additional, van der Hoeven, Erik J.R.J., additional, Hoff, Christiaan, additional, Hogewoning, Anna, additional, Hogewoning, Cornelis R.C., additional, Hoogendoorn, Stefan, additional, van Hoorn, Francois, additional, van der Hul, René L., additional, van Hulst, Rieke, additional, Imani, Farshad, additional, Inberg, Bas, additional, Intven, Martijn P.W., additional, Janssen, Pedro, additional, de Jong, Chris E.J., additional, Jonkers, Jacoline, additional, Jou-Valencia, Daniela, additional, Keizers, Bas, additional, Ketelaers, Stijn H.J., additional, Knöps, Eva, additional, van Koeverden, Sebastiaan, additional, Kok, Sylvia, additional, Kolderman, Stephanie E.M., additional, de Korte, Fleur I., additional, Kortekaas, Robert T.J., additional, Korving, Julie C., additional, Koster, Ingrid M., additional, Krdzalic, Jasenko, additional, Krielen, Pepijn, additional, Kroese, Leonard F., additional, Krul, Eveline J.T., additional, Lahuis, Derk H.H., additional, Lamme, Bas, additional, van Landeghem, An A.G., additional, Leijtens, Jeroen W.A., additional, Leseman-Hoogenboom, Mathilde M., additional, de Lijster, Manou S., additional, Marsman, Martijn S., additional, Martens, MilouH., additional, Masselink, Ilse, additional, van der Meij, Wout, additional, Meijnen, Philip, additional, Melenhorst, Jarno, additional, de Mey, Dietrich J.L., additional, Moelker-Galuzina, Julia, additional, Morsink, Linda, additional, Mulder, Erik J., additional, Muller, Karin, additional, Musters, Gijsbert D., additional, Neijenhuis, Peter A., additional, de Nes, Lindsey C.F., additional, Nielen, M., additional, van den Nieuwboer, Jan B.J., additional, Nieuwenhuis, Jonanne F., additional, Nonner, Joost, additional, Noordman, Bo J., additional, Nordkamp, Stefi, additional, Olthof, Pim B., additional, Oosterling, Steven J., additional, Ootes, Daan, additional, Oppedijk, Vera, additional, Ott, Pieter, additional, Paulusma, Ida, additional, Peeters, Koen C.M.J., additional, Pereboom, Ilona T.A., additional, Peringa, Jan, additional, Pironet, Zoë, additional, Plate, Joost D.J., additional, Polat, Fatih, additional, Poodt, Ingrid G.M., additional, Posma, Lisanne A.E., additional, Prette, Jeroen F., additional, Pultrum, Bareld B., additional, Qaderi, Seyed M., additional, van Rees, Jan M., additional, Renger, Rutger-Jan, additional, Rombouts, Anouk J.M., additional, Roosen, Lodewijk J., additional, Roskott-ten Brinke, Ellen A., additional, Rothbarth, Joost, additional, Rouw, Dennis B., additional, Rozema, Tom, additional, Rütten, Heidi, additional, Rutten, Harm J.T., additional, van der Sande, Marit E., additional, Schaafsma, Boudewijn E., additional, Schasfoort, Renske A., additional, Scheurkogel, Merel M., additional, Schouten van der Velden, Arjan P., additional, Schreurs, Wilhelmina H., additional, Schuivens, Puck M.E., additional, Sietses, Colin, additional, Simons, Petra C.G., additional, Slob, Marjan J., additional, Slooter, Gerrit D., additional, van der Sluis, Martsje, additional, Smalbroek, Bo P., additional, Smits, Anke B., additional, Spillenaar-Bilgen, Ernst J., additional, Spruit, Patty H., additional, Stam, Tanja C., additional, Stoker, Jaap, additional, Talsma, Aaldert K., additional, Temmink, Sofieke J.D., additional, The, G.Y. Mireille, additional, Tielbeek, Jeroen A.W., additional, van Tilborg, Aukje A.J.M., additional, van Tilborg, Fiek, additional, van Trier, Dorothée, additional, Tuynman, Jurriaan B., additional, van der Valk, Maxime J.M., additional, Vanhooymissen, Inge J.S., additional, Vasbinder, G. Boudewijn C., additional, Veeken, Cornelis J., additional, Velema, Laura A., additional, van de Ven, Anthony W.H., additional, Verdaasdonk, Emiel G.G., additional, Verduin, Wouter M., additional, Verhagen, Tim, additional, Verheijen, Paul M., additional, Vermaas, Maarten, additional, Verrijssen, An-Sofie E., additional, Verschuur, Anna V.D., additional, Schaik, Harmke Verwoerd-van, additional, Vliegen, Roy F.A., additional, Voets, Sophie, additional, Vogelaar, F. Jeroen, additional, Vogelij, Clementine L.A., additional, Vos-Westerman, Johanna, additional, de Vries, Marianne, additional, Vroemen, Joy C., additional, van Vugt, Bas S.T., additional, Wegdam, Johannes A., additional, van Wely, Bob J., additional, Westerterp, Marinke, additional, van Westerveld, Paul P., additional, van Westreenen, Henderik L., additional, Wijma, Allard G., additional, de Wilt, Johannes H.W., additional, de Wit, Bart W.K., additional, Wit, Fennie, additional, Woensdregt, Karlijn, additional, van Woerden, Victor, additional, van der Wolf, Floor S.W., additional, van der Wolk, Sander, additional, Wybenga, Johannes M., additional, van der Zaag, Edwin S., additional, Zamaray, Bobby, additional, Zandvoort, Herman J.A., additional, van der Zee, Dennis, additional, Zeilstra, Annette P., additional, Zheng, Kang J., additional, Zimmerman, David D.E., additional, and Zorgdrager, Marcel, additional

Published
2024
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5. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial

Author

Hop, WC, Opmeer, BC, Reitsma, JB, Scholte, RA, Waltmann, EWH, Legemate, DA, Bartelsman, JF, Meijer, DW, Ünlü, Ç, Kluit, AB, El-Massoudi, Y, Vuylsteke, RJCLM, Tanis, PJ, Matthijsen, R, Polle, SW, Lagarde, SM, Gisbertz, SS, Wijers, O, van der Bilt, JDW, Boermeester, MA, Blom, R, Gooszen, JAH, Schreinemacher, MHF, van der Zande, T, Leeuwenburgh, MMN, Bartels, SAL, Hesp, WLEM, Koet, L, van der Schelling, GP, van Dessel, E, van Zeeland, MLP, Lensvelt, MMA, Nijhof, H, Verest, S, Buijs, M, Wijsman, JH, Stassen, LPS, Klinkert, M, de Maat, MFG, Sellenraad, G, Jeekel, J, Kleinrensink, GJ, Tha-In, T, Nijboer, WN, Boom, MJ, Verbeek, PCM, Sietses, C, Stommel, MWJ, van Huijstee, PJ, Merkus, JWS, Eefting, D, Mieog, JSD, van Geldere, D, Patijn, GA, de Vries, M, Boskamp, M, Bentohami, A, Bijlsma, TS, de Korte, N, Nio, D, Rijna, H, Luttikhold, J, van Gool, MH, Fekkes, JF, Akkersdijk, GJM, Heuff, G, Jutte, EH, Kortmann, BA, Werkman, JM, Laméris, W, Rietbergen, L, Frankenmolen, P, Draaisma, WA, Stam, MAW, Verweij, MS, Karsten, TM, de Nes, LC, Fortuin, S, de Castro, SM, Doeksen, A, Simons, MP, Koffeman, GI, Steller, EP, Tuynman, JB, Boele van Hensbroek, P, Mok, M, van Diepen, SR, Hulsewé, KWE, Melenhorst, J, Stoot, JHMB, Fransen, S, Sosef, MN, van Bastelaar, J, Vissers, YLJ, Douchy, TPD, Christiaansen, CE, Smeenk, R, Pijnenburg, AM, Tanaydin, V, Veger, HTC, Clermonts, SHEM, Al-Taher, M, de Graaf, EJR, Menon, AG, Vermaas, M, Cense, HA, Jutte, E, Wiezer, MJ, Smits, AB, Westerterp, M, Marsman, HA, Hendriks, ER, van Ruler, O, Vriens, EJC, Vogten, JM, van Rossem, CC, Ohanis, D, Tanis, E, van Grinsven, J, Maring, JK, Heisterkamp, J, Besselink, MGH, Borel Rinkes, IHM, Molenaar, IQ, Joosten, JJA, Jongkind, V, Diepenhorst, GMP, Boute, MC, Smeenge, M, Nielsen, K, Harlaar, JJ, Luyer, MDP, van Montfort, G, Smulders, JF, Daams, F, van Haren, E, Nieuwenhuijzen, GAP, Lauret, GJ, Pereboom, ITA, Stokmans, RA, Birindelli, A, Bianchi, E, Pellegrini, S, Terrasson, I, Wolthuis, A, de Buck van Overstraeten, A, Nijs, S, Lambrichts, Daniël P V, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Hoofwijk, Anton G M, Belgers, Eric H J, Stockmann, Hein B A C, Eijsbouts, Quirijn A J, Gerhards, Michael F, van Wagensveld, Bart A, van Geloven, Anna A W, Crolla, Rogier M P H, Nienhuijs, Simon W, Govaert, Marc J P M, di Saverio, Salomone, D'Hoore, André J L, Consten, Esther C J, van Grevenstein, Wilhelmina M U, Pierik, Robert E G J M, Kruyt, Philip M, van der Hoeven, Joost A B, Steup, Willem H, Catena, Fausto, Konsten, Joop L M, Vermeulen, Jefrey, van Dieren, Susan, Bemelman, Willem A, and Lange, Johan F

Published
2019
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6. A personalized app to improve quality of life of patients with a stoma: A protocol for a multicentre randomized controlled trial.

Author

van der Storm, Sebastiaan L., Bemelman, Willem A., van Dieren, Susan, Schijven, Marlies P., Consten, Esther C. J., Govaert, Marc J. P. M., Tuynman, Jurriaan B., Oosterling, Steven J., Grotenhuis, Brechtje A., Smits, Anke B., Marsman, Hendrik A., Buskens, Christianne J., Hompes, Roel, Kusters, Miranda, van Rossem, Charles C., van Duyn, Eino B., De Nes, Lindsey C. F., Verdaasdonk, Emiel, de Vries Reilingh, Tammo S., and Vening, Wouter

Subjects
OSTOMATES, PATIENT reported outcome measures, RANDOMIZED controlled trials, COLOSTOMY, QUALITY of life, ILEOSTOMY, LENGTH of stay in hospitals
Abstract

Aim: Proper education, guidance and support is crucial before and following creation of a stoma. Patients with a stoma and their close relatives need to adapt to and cope with this new – and sometimes unforeseen – situation, which may result in insecurities and a variety of psychosocial problems. Self‐efficacy is associated both with a reduction in psychosocial problems and with improved quality of life. The main objective of this study was to investigate whether self‐reported quality of life of patients with a stoma can be enhanced by offering personalized and timed guidance, as well as peer contact, in a patient‐centred mobile application. Method: A multicentre, double‐blind, randomized controlled trial will be conducted. Consented adults >18 years of age who will receive an ileostomy or colostomy and possess an eligible smartphone will be included. The intervention group will be given the full version of the application (containing personalized and timed guidance, such as operation‐specific information and information on the associated care pathway) to install on their smartphone. In addition, the intervention group has access to a protected peer‐support platform within the app. The control group will receive a restricted version of the application that contains only generic (non‐personalized) stoma‐related information. The primary outcome is quality of life, 3 months postoperatively. Secondary outcomes are Patient Reported Outcome Measures (PROMs), such as psychological adaption, as well as number of complications, re‐admission and re‐operation rates and the length of hospital stay. Results: Patient enrolment began in March 2021. Data collection was not complete when this protocol was submitted. Conclusion: We hypothesize that patients with a stoma who are supported by the intervention version of the app will report a significantly higher quality of life than patients with a stoma who are supported by the control version of the app (ie, are not offered personalized and timed guidance and information and do not have access to peer support in the app). [ABSTRACT FROM AUTHOR]

Published
2023
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7. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial

Author

Hop, W C, Opmeer, B C, Reitsma, J B, Scholte, R A, Waltmann, E W H, Legemate, D A, Bartelsman, J F, Meijer, D W, de Brouwer, M, van Dalen, J, Durbridge, M, Geerdink, M, Ilbrink, G J, Mehmedovic, S, Middelhoek, P, Di Saverio, Salomone, Boom, M J, Consten, E C J, van der Bilt, J D W, van Olden, G D J, Stam, M A W, Verweij, M S, Busch, O R C, Buskens, C J, El-Massoudi, Y, Kluit, A B, van Rossem, C C, Schijven, M P, Tanis, P J, Unlu, C, Gerhards, M F, Karsten, T M, de Nes, L C, Rijna, H, van Wagensveld, B A, Koffeman, G I, Steller, E P, Tuynman, J B, Bruin, S C, van der Peet, D L, Blanken-Peeters, C F J M, Cense, H A, Jutte, E, Crolla, R M P H, van der Schelling, G P, van Zeeland, M, de Graaf, E J R, Groenendijk, R P R, Vermaas, M, Schouten, O, de Vries, M R, Prins, H A, Lips, D J, Bosker, R J I, van der Hoeven, J A B, Diks, J, Plaisier, P W, Kruyt, P M, Sietses, C, Stommel, M W J, Nienhuijs, S W, de Hingh, I H J T, Luyer, M D P, van Montfort, G, Ponten, E H, Smulders, J F, van Duyn, E B, Klaase, J M, Swank, D J, Ottow, R T, Stockmann, H B A C, Vermeulen, J, Vuylsteke, R J C L M, Belgers, H J, Fransen, S, von Meijenfeldt, E M, Sosef, M N, van Geloven, A A W, Hendriks, E R, ter Horst, B, Leeuwenburgh, M M N, van Ruler, O, Vogten, J M, Vriens, E J C, Westerterp, M, Eijsbouts, Q A J, Bentohami, A, Bijlsma, T S, de Korte, N, Nio, D, Govaert, M J P M, Joosten, J J A, Tollenaar, R A E M, Stassen, L P S, Wiezer, M J, Hazebroek, E J, Smits, A B, van Westreenen, H L, Lange, J F, Brandt, A, Nijboer, W N, Toorenvliet, B R, Weidema, W F, Coene, P P L O, Mannaerts, G H H, den Hartog, D, de Vos, R J, Zengerink, J F, Hoofwijk, A G M, Hulsewé, K W E, Melenhorst, J, Stoot, J H M B, Steup, W H, Huijstee, P J, Merkus, J W S, Wever, J J, Maring, J K, Heisterkamp, J, van Grevenstein, W M U, Vriens, M R, Besselink, M G H, Borel Rinkes, I H M, Witkamp, A J, Slooter, G D, Konsten, J L M, Engel, A F, Pierik, E G J M, Frakking, T G, van Geldere, D, Patijn, G A, D'Hoore, A J L, de Buck van Overstraeten, A, Miserez, M, Terrasson, I, Wolthuis, A, De Blasiis, M G, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Consten, Esther C, Belgers, Eric H, van Geloven, Anna A, Gerhards, Michael F, Govaert, Marc J, van Grevenstein, Wilhelmina M, Hoofwijk, Anton G, Kruyt, Philip M, Nienhuijs, Simon W, Boermeester, Marja A, Vermeulen, Jefrey, van Dieren, Susan, Lange, Johan F, and Bemelman, Willem A

Published
2015
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8. Detection of colon cancer recurrences during follow-up care by general practitioners versus surgeons

Author

Vos, Julien A. M., Sert, Eda, Busschers, Wim B., Duineveld, Laura A. M., Wieldraaijer, Thijs, Wind, Jan, Donkervoort, Sandra C., Govaert, Marc, Beverdam, Frédérique H., Smits, Anke, Bemelman, Wilhelmus A., Heuff, Gijsbert, van Weert, Henk C. P. M., van Asselt, Kristel M., General practice, Graduate School, APH - Personalized Medicine, CCA - Cancer Treatment and Quality of Life, APH - Methodology, Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, APH - Quality of Care, ACS - Heart failure & arrhythmias, CCA - Imaging and biomarkers, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Cancer Research, Oncology
Abstract

Background In the I CARE study, colon cancer patients were randomly assigned to receive follow-up care from either a general practitioner (GP) or a surgeon. Here, we address a secondary outcome, namely, detection of recurrences and effect on time to detection of transferring care from surgeon to GP. Methods Pattern, stage, and treatment of recurrences were described after 3 years. Time to event was defined as date of surgery, until date of recurrence or last follow-up, with death as competing event. Effects on time to recurrence and death were estimated as hazard ratios (HRs) using Cox regression. Restricted mean survival times were estimated. Results Of 303 patients, 141 were randomly assigned to the GP and 162 to the surgeon. Patients were male (67%) with a mean age of 68.0 (8.4) years. During follow-up, 46 recurrences were detected; 18 (13%) in the GP vs 28 (17%) in the surgeon group. Most recurrences were detected via abnormal follow-up tests (74%) and treated with curative intent (59%). Hazard ratio for recurrence was 0.75 (95% confidence interval [CI] = 0.41 to 1.36) in GP vs surgeon group. Patients in the GP group remained in the disease-free state slightly longer (2.76 vs 2.71 years). Of the patients, 38 died during follow-up; 15 (11%) in the GP vs 23 (14%) in the surgeon group. Of these, 21 (55%) deaths were related to colon cancer. There were no differences in overall deaths between the groups (HR = 0.76, 95% CI = 0.39 to 1.46). Conclusion Follow-up provided by GPs vs surgeons leads to similar detection of recurrences. Also, no differences in mortality were found.

Published
2023

11. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES) : a multicentre, parallel-group, randomised, open-label, superiority trial

Author

Lambrichts, Daniël P.V., Vennix, Sandra, Musters, Gijsbert D., Mulder, Irene M., Swank, Hilko A., Hoofwijk, Anton G.M., Belgers, Eric H.J., Stockmann, Hein B.A.C., Eijsbouts, Quirijn A.J., Gerhards, Michael F., van Wagensveld, Bart A., van Geloven, Anna A.W., Crolla, Rogier M.P.H., Nienhuijs, Simon W., Govaert, Marc J.P.M., di Saverio, Salomone, D'Hoore, André J.L., Consten, Esther C.J., van Grevenstein, Wilhelmina M.U., Pierik, Robert E.G.J.M., Kruyt, Philip M., van der Hoeven, Joost A.B., Steup, Willem H., Catena, Fausto, Konsten, Joop L.M., Vermeulen, Jefrey, van Dieren, S., Bemelman, Willem A., Lange, Johan F., Hop, W. C., Opmeer, B. C., Reitsma, J. B., Meijer, D. W., Matthijsen, R., Blom, R., Wijsman, J. H., de Maat, M. F.G., Boom, M. J., de Vries, M., Stam, M. A.W., Verweij, M. S., Steller, E. P., de Graaf, E. J.R., Vermaas, M., Wiezer, M. J., Smits, A. B., Hendriks, E. R., Borel Rinkes, I. H.M., Molenaar, I. Q., Nijs, S., Lambrichts, Daniël P.V., Vennix, Sandra, Musters, Gijsbert D., Mulder, Irene M., Swank, Hilko A., Hoofwijk, Anton G.M., Belgers, Eric H.J., Stockmann, Hein B.A.C., Eijsbouts, Quirijn A.J., Gerhards, Michael F., van Wagensveld, Bart A., van Geloven, Anna A.W., Crolla, Rogier M.P.H., Nienhuijs, Simon W., Govaert, Marc J.P.M., di Saverio, Salomone, D'Hoore, André J.L., Consten, Esther C.J., van Grevenstein, Wilhelmina M.U., Pierik, Robert E.G.J.M., Kruyt, Philip M., van der Hoeven, Joost A.B., Steup, Willem H., Catena, Fausto, Konsten, Joop L.M., Vermeulen, Jefrey, van Dieren, S., Bemelman, Willem A., Lange, Johan F., Hop, W. C., Opmeer, B. C., Reitsma, J. B., Meijer, D. W., Matthijsen, R., Blom, R., Wijsman, J. H., de Maat, M. F.G., Boom, M. J., de Vries, M., Stam, M. A.W., Verweij, M. S., Steller, E. P., de Graaf, E. J.R., Vermaas, M., Wiezer, M. J., Smits, A. B., Hendriks, E. R., Borel Rinkes, I. H.M., Molenaar, I. Q., and Nijs, S.

Published
2019

12. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial

Author

Arts Assistenten CTC, MS CGO, Cancer, Cardiovasculaire Epi Team 1, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, AIOS Psychiatrie, Trialbureau Vitale Functies, Projectafdeling functional imaging, Brain, Projectafdeling ALS, Heelkunde Opleiding, Groep Timmers, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Regenerative Medicine and Stem Cells, Onderzoek Longziekten, Lambrichts, Daniël P.V., Vennix, Sandra, Musters, Gijsbert D., Mulder, Irene M., Swank, Hilko A., Hoofwijk, Anton G.M., Belgers, Eric H.J., Stockmann, Hein B.A.C., Eijsbouts, Quirijn A.J., Gerhards, Michael F., van Wagensveld, Bart A., van Geloven, Anna A.W., Crolla, Rogier M.P.H., Nienhuijs, Simon W., Govaert, Marc J.P.M., di Saverio, Salomone, D'Hoore, André J.L., Consten, Esther C.J., van Grevenstein, Wilhelmina M.U., Pierik, Robert E.G.J.M., Kruyt, Philip M., van der Hoeven, Joost A.B., Steup, Willem H., Catena, Fausto, Konsten, Joop L.M., Vermeulen, Jefrey, van Dieren, S., Bemelman, Willem A., Lange, Johan F., Hop, W. C., Opmeer, B. C., Reitsma, J. B., Meijer, D. W., Matthijsen, R., Blom, R., Wijsman, J. H., de Maat, M. F.G., Boom, M. J., de Vries, M., Stam, M. A.W., Verweij, M. S., Steller, E. P., de Graaf, E. J.R., Vermaas, M., Wiezer, M. J., Smits, A. B., Hendriks, E. R., Borel Rinkes, I. H.M., Molenaar, I. Q., Nijs, S., Arts Assistenten CTC, MS CGO, Cancer, Cardiovasculaire Epi Team 1, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, AIOS Psychiatrie, Trialbureau Vitale Functies, Projectafdeling functional imaging, Brain, Projectafdeling ALS, Heelkunde Opleiding, Groep Timmers, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Regenerative Medicine and Stem Cells, Onderzoek Longziekten, Lambrichts, Daniël P.V., Vennix, Sandra, Musters, Gijsbert D., Mulder, Irene M., Swank, Hilko A., Hoofwijk, Anton G.M., Belgers, Eric H.J., Stockmann, Hein B.A.C., Eijsbouts, Quirijn A.J., Gerhards, Michael F., van Wagensveld, Bart A., van Geloven, Anna A.W., Crolla, Rogier M.P.H., Nienhuijs, Simon W., Govaert, Marc J.P.M., di Saverio, Salomone, D'Hoore, André J.L., Consten, Esther C.J., van Grevenstein, Wilhelmina M.U., Pierik, Robert E.G.J.M., Kruyt, Philip M., van der Hoeven, Joost A.B., Steup, Willem H., Catena, Fausto, Konsten, Joop L.M., Vermeulen, Jefrey, van Dieren, S., Bemelman, Willem A., Lange, Johan F., Hop, W. C., Opmeer, B. C., Reitsma, J. B., Meijer, D. W., Matthijsen, R., Blom, R., Wijsman, J. H., de Maat, M. F.G., Boom, M. J., de Vries, M., Stam, M. A.W., Verweij, M. S., Steller, E. P., de Graaf, E. J.R., Vermaas, M., Wiezer, M. J., Smits, A. B., Hendriks, E. R., Borel Rinkes, I. H.M., Molenaar, I. Q., and Nijs, S.

Published
2019

13. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial

Author

Lambrichts, Daniël P V, primary, Vennix, Sandra, additional, Musters, Gijsbert D, additional, Mulder, Irene M, additional, Swank, Hilko A, additional, Hoofwijk, Anton G M, additional, Belgers, Eric H J, additional, Stockmann, Hein B A C, additional, Eijsbouts, Quirijn A J, additional, Gerhards, Michael F, additional, van Wagensveld, Bart A, additional, van Geloven, Anna A W, additional, Crolla, Rogier M P H, additional, Nienhuijs, Simon W, additional, Govaert, Marc J P M, additional, di Saverio, Salomone, additional, D'Hoore, André J L, additional, Consten, Esther C J, additional, van Grevenstein, Wilhelmina M U, additional, Pierik, Robert E G J M, additional, Kruyt, Philip M, additional, van der Hoeven, Joost A B, additional, Steup, Willem H, additional, Catena, Fausto, additional, Konsten, Joop L M, additional, Vermeulen, Jefrey, additional, van Dieren, Susan, additional, Bemelman, Willem A, additional, Lange, Johan F, additional, Hop, WC, additional, Opmeer, BC, additional, Reitsma, JB, additional, Scholte, RA, additional, Waltmann, EWH, additional, Legemate, DA, additional, Bartelsman, JF, additional, Meijer, DW, additional, Ünlü, Ç, additional, Kluit, AB, additional, El-Massoudi, Y, additional, Vuylsteke, RJCLM, additional, Tanis, PJ, additional, Matthijsen, R, additional, Polle, SW, additional, Lagarde, SM, additional, Gisbertz, SS, additional, Wijers, O, additional, van der Bilt, JDW, additional, Boermeester, MA, additional, Blom, R, additional, Gooszen, JAH, additional, Schreinemacher, MHF, additional, van der Zande, T, additional, Leeuwenburgh, MMN, additional, Bartels, SAL, additional, Hesp, WLEM, additional, Koet, L, additional, van der Schelling, GP, additional, van Dessel, E, additional, van Zeeland, MLP, additional, Lensvelt, MMA, additional, Nijhof, H, additional, Verest, S, additional, Buijs, M, additional, Wijsman, JH, additional, Stassen, LPS, additional, Klinkert, M, additional, de Maat, MFG, additional, Sellenraad, G, additional, Jeekel, J, additional, Kleinrensink, GJ, additional, Tha-In, T, additional, Nijboer, WN, additional, Boom, MJ, additional, Verbeek, PCM, additional, Sietses, C, additional, Stommel, MWJ, additional, van Huijstee, PJ, additional, Merkus, JWS, additional, Eefting, D, additional, Mieog, JSD, additional, van Geldere, D, additional, Patijn, GA, additional, de Vries, M, additional, Boskamp, M, additional, Bentohami, A, additional, Bijlsma, TS, additional, de Korte, N, additional, Nio, D, additional, Rijna, H, additional, Luttikhold, J, additional, van Gool, MH, additional, Fekkes, JF, additional, Akkersdijk, GJM, additional, Heuff, G, additional, Jutte, EH, additional, Kortmann, BA, additional, Werkman, JM, additional, Laméris, W, additional, Rietbergen, L, additional, Frankenmolen, P, additional, Draaisma, WA, additional, Stam, MAW, additional, Verweij, MS, additional, Karsten, TM, additional, de Nes, LC, additional, Fortuin, S, additional, de Castro, SM, additional, Doeksen, A, additional, Simons, MP, additional, Koffeman, GI, additional, Steller, EP, additional, Tuynman, JB, additional, Boele van Hensbroek, P, additional, Mok, M, additional, van Diepen, SR, additional, Hulsewé, KWE, additional, Melenhorst, J, additional, Stoot, JHMB, additional, Fransen, S, additional, Sosef, MN, additional, van Bastelaar, J, additional, Vissers, YLJ, additional, Douchy, TPD, additional, Christiaansen, CE, additional, Smeenk, R, additional, Pijnenburg, AM, additional, Tanaydin, V, additional, Veger, HTC, additional, Clermonts, SHEM, additional, Al-Taher, M, additional, de Graaf, EJR, additional, Menon, AG, additional, Vermaas, M, additional, Cense, HA, additional, Jutte, E, additional, Wiezer, MJ, additional, Smits, AB, additional, Westerterp, M, additional, Marsman, HA, additional, Hendriks, ER, additional, van Ruler, O, additional, Vriens, EJC, additional, Vogten, JM, additional, van Rossem, CC, additional, Ohanis, D, additional, Tanis, E, additional, van Grinsven, J, additional, Maring, JK, additional, Heisterkamp, J, additional, Besselink, MGH, additional, Borel Rinkes, IHM, additional, Molenaar, IQ, additional, Joosten, JJA, additional, Jongkind, V, additional, Diepenhorst, GMP, additional, Boute, MC, additional, Smeenge, M, additional, Nielsen, K, additional, Harlaar, JJ, additional, Luyer, MDP, additional, van Montfort, G, additional, Smulders, JF, additional, Daams, F, additional, van Haren, E, additional, Nieuwenhuijzen, GAP, additional, Lauret, GJ, additional, Pereboom, ITA, additional, Stokmans, RA, additional, Birindelli, A, additional, Bianchi, E, additional, Pellegrini, S, additional, Terrasson, I, additional, Wolthuis, A, additional, de Buck van Overstraeten, A, additional, and Nijs, S, additional

Published
2019
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14. The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037)

Author

Bruin Sjoerd C, Mannaerts Guido HH, Cense Huib A, Blanken-Peeters Charlotte FJM, Neijenhuis Peter A, Karsten Thomas M, Hoofwijk Anton GM, Gerhards Michael F, van Duijn Eino B, Consten Esther CJ, Slooter Gerrit D, Coene Peter-Paul LO, van Wagensveld Bart A, Tollenaar Rob AEM, Stockmann Hein BAC, Prins Hubert A, Pierik Robert EGJM, Weidema Wibo F, de Graaf Eelco JR, Steup Willem H, Swank Dingeman J, Kruyt Philip M, Boom Maarten J, Bosker Robbert JI, Nienhuijs Simon W, Sosef Meindert N, Crolla Rogier MPH, Stassen Laurents PS, van der Hoeven Joost AB, Mulder Irene M, Lange Johan F, Vermeulen Jefrey, Swank Hilko A, Eijsbouts Quirijn AJ, Wiezer Marinus J, Hazebroek Eric J, van Geloven Anna AW, Maring John K, D'Hoore André JL, Kartheuser Alex, Remue Christophe, van Grevenstein Helma MU, Konsten Joop LM, van der Peet Donald L, Govaert Marc JPM, Engel Alexander F, Reitsma Johannes B, and Bemelman Willem A

Subjects
Surgery, RD1-811
Abstract

Abstract Background Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis). Methods/Design In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm). Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm). The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%). Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and power = 90%) in favour of the patients with resection with primary anastomosis. Secondary endpoints for both arms are the number of days alive and outside the hospital, health related quality of life, health care utilisation and associated costs. Discussion The Ladies trial is a nationwide multicentre randomised trial on perforated diverticulitis that will provide evidence on the merits of laparoscopic lavage and drainage for purulent generalised peritonitis and on the optimal resectional strategy for both purulent and faecal generalised peritonitis. Trial registration Nederlands Trial Register NTR2037

Published
2010
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15. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis : A multicentre, parallel-group, randomised, open-label trial

Author

Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Consten, Esther C, Belgers, Eric H, van Geloven, Anna A, Gerhards, Michael F., Govaert, Marc J, Van Grevenstein, Wilhelmina M., Hoofwijk, Anton G, Kruyt, Philip M., Nienhuijs, Simon W, Boermeester, Marja A, Vermeulen, Jefrey, Van Dieren, Susan, Lange, Johan F, Bemelman, Willem A, and Ladies trial colloborators

Subjects
Male, Research Support, Non-U.S. Gov't, Middle Aged, Peritonitis, Diverticulitis, Colonic, Multicenter Study, Treatment Outcome, Colon, Sigmoid, Intestinal Perforation, Randomized Controlled Trial, Journal Article, Humans, Female, Laparoscopy, Peritoneal Lavage, Comparative Study
Abstract

Background Case series suggest that laparoscopic peritoneal lavage might be a promising alternative to sigmoidectomy in patients with perforated diverticulitis. We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in patients with purulent perforated diverticulitis, with respect to overall long-term morbidity and mortality. Methods We did a multicentre, parallel-group, randomised, open-label trial in 34 teaching hospitals and eight academic hospitals in Belgium, Italy, and the Netherlands (the Ladies trial). The Ladies trial is split into two groups: the LOLA group comparing laparoscopic lavage with sigmoidectomy and the DIVA group comparing Hartmann's procedure with sigmoidectomy plus primary anastomosis. The DIVA section of this trial is still underway but here we report the results of the LOLA section. Patients with purulent perforated diverticulitis were enrolled for LOLA, excluding patients with faecal peritonitis, aged older than 85 years, with high-dose steroid use (≤20 mg daily), and haemodynamic instability. Patients were randomly assigned (2:1:1; stratified by age [

Published
2015

16. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: A multicentre, parallel-group, randomised, open-label trial

Author

Verpleegafd Vaatchirurgie D4 Oost, UMC Utrecht, MS CGO, Cancer, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Consten, Esther C, Belgers, Eric H, van Geloven, Anna A, Gerhards, Michael F., Govaert, Marc J, Van Grevenstein, Wilhelmina M., Hoofwijk, Anton G, Kruyt, Philip M., Nienhuijs, Simon W, Boermeester, Marja A, Vermeulen, Jefrey, Van Dieren, Susan, Lange, Johan F, Bemelman, Willem A, Ladies trial colloborators, Verpleegafd Vaatchirurgie D4 Oost, UMC Utrecht, MS CGO, Cancer, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Consten, Esther C, Belgers, Eric H, van Geloven, Anna A, Gerhards, Michael F., Govaert, Marc J, Van Grevenstein, Wilhelmina M., Hoofwijk, Anton G, Kruyt, Philip M., Nienhuijs, Simon W, Boermeester, Marja A, Vermeulen, Jefrey, Van Dieren, Susan, Lange, Johan F, Bemelman, Willem A, and Ladies trial colloborators

Published
2015

17. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial

Author

Vennix, Sandra, primary, Musters, Gijsbert D, additional, Mulder, Irene M, additional, Swank, Hilko A, additional, Consten, Esther C, additional, Belgers, Eric H, additional, van Geloven, Anna A, additional, Gerhards, Michael F, additional, Govaert, Marc J, additional, van Grevenstein, Wilhelmina M, additional, Hoofwijk, Anton G, additional, Kruyt, Philip M, additional, Nienhuijs, Simon W, additional, Boermeester, Marja A, additional, Vermeulen, Jefrey, additional, van Dieren, Susan, additional, Lange, Johan F, additional, Bemelman, Willem A, additional, Hop, W C, additional, Opmeer, B C, additional, Reitsma, J B, additional, Scholte, R A, additional, Waltmann, E W H, additional, Legemate, D A, additional, Bartelsman, J F, additional, Meijer, D W, additional, de Brouwer, M, additional, van Dalen, J, additional, Durbridge, M, additional, Geerdink, M, additional, Ilbrink, G J, additional, Mehmedovic, S, additional, Middelhoek, P, additional, Di Saverio, Salomone, additional, Boom, M J, additional, Consten, E C J, additional, van der Bilt, J D W, additional, van Olden, G D J, additional, Stam, M A W, additional, Verweij, M S, additional, Busch, O R C, additional, Buskens, C J, additional, El-Massoudi, Y, additional, Kluit, A B, additional, van Rossem, C C, additional, Schijven, M P, additional, Tanis, P J, additional, Unlu, C, additional, Gerhards, M F, additional, Karsten, T M, additional, de Nes, L C, additional, Rijna, H, additional, van Wagensveld, B A, additional, Koffeman, G I, additional, Steller, E P, additional, Tuynman, J B, additional, Bruin, S C, additional, van der Peet, D L, additional, Blanken-Peeters, C F J M, additional, Cense, H A, additional, Jutte, E, additional, Crolla, R M P H, additional, van der Schelling, G P, additional, van Zeeland, M, additional, de Graaf, E J R, additional, Groenendijk, R P R, additional, Vermaas, M, additional, Schouten, O, additional, de Vries, M R, additional, Prins, H A, additional, Lips, D J, additional, Bosker, R J I, additional, van der Hoeven, J A B, additional, Diks, J, additional, Plaisier, P W, additional, Kruyt, P M, additional, Sietses, C, additional, Stommel, M W J, additional, Nienhuijs, S W, additional, de Hingh, I H J T, additional, Luyer, M D P, additional, van Montfort, G, additional, Ponten, E H, additional, Smulders, J F, additional, van Duyn, E B, additional, Klaase, J M, additional, Swank, D J, additional, Ottow, R T, additional, Stockmann, H B A C, additional, Vermeulen, J, additional, Vuylsteke, R J C L M, additional, Belgers, H J, additional, Fransen, S, additional, von Meijenfeldt, E M, additional, Sosef, M N, additional, van Geloven, A A W, additional, Hendriks, E R, additional, ter Horst, B, additional, Leeuwenburgh, M M N, additional, van Ruler, O, additional, Vogten, J M, additional, Vriens, E J C, additional, Westerterp, M, additional, Eijsbouts, Q A J, additional, Bentohami, A, additional, Bijlsma, T S, additional, de Korte, N, additional, Nio, D, additional, Govaert, M J P M, additional, Joosten, J J A, additional, Tollenaar, R A E M, additional, Stassen, L P S, additional, Wiezer, M J, additional, Hazebroek, E J, additional, Smits, A B, additional, van Westreenen, H L, additional, Lange, J F, additional, Brandt, A, additional, Nijboer, W N, additional, Toorenvliet, B R, additional, Weidema, W F, additional, Coene, P P L O, additional, Mannaerts, G H H, additional, den Hartog, D, additional, de Vos, R J, additional, Zengerink, J F, additional, Hoofwijk, A G M, additional, Hulsewé, K W E, additional, Melenhorst, J, additional, Stoot, J H M B, additional, Steup, W H, additional, Huijstee, P J, additional, Merkus, J W S, additional, Wever, J J, additional, Maring, J K, additional, Heisterkamp, J, additional, van Grevenstein, W M U, additional, Vriens, M R, additional, Besselink, M G H, additional, Borel Rinkes, I H M, additional, Witkamp, A J, additional, Slooter, G D, additional, Konsten, J L M, additional, Engel, A F, additional, Pierik, E G J M, additional, Frakking, T G, additional, van Geldere, D, additional, Patijn, G A, additional, D'Hoore, A J L, additional, de Buck van Overstraeten, A, additional, Miserez, M, additional, Terrasson, I, additional, Wolthuis, A, additional, and De Blasiis, M G, additional

Published
2015
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18. Improving care after colon cancer treatment in The Netherlands, personalised care to enhance quality of life (I CARE study): study protocol for a randomised controlled trial

Author

Duineveld, Laura A.M., primary, Wieldraaijer, Thijs, additional, van Asselt, Kristel M., additional, Nugteren, Ineke C., additional, Donkervoort, Sandra C., additional, van de Ven, Anthony W.H., additional, Smits, Anke B., additional, van Geloven, Anna A.W., additional, Bemelman, Willem A., additional, Beverdam, Frederique H., additional, van Tets, Willem F., additional, Govaert, Marc J.P.M., additional, Bosmans, Judith E., additional, Leeuw, Irma M. Verdonck-de, additional, van Uden-Kraan, Cornelia F., additional, van Weert, Henk C.P.M., additional, and Wind, Jan, additional

Published
2015
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21. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial.

Author

Musters, Gijsbert D., Swank, Hilko A., Boermeester, Marja A., Bemelman, Willem A., Vennix, Sandra, Kruyt, Philip M., Nienhuijs, Simon W., Vermeulen, Jefrey, van Dieren, Susan, Mulder, Irene M., Lange, Johan F., Consten, Esther C., Belgers, Eric H., van Geloven, Anna A., Gerhards, Michael F., Govaert, Marc J., van Grevenstein, Wilhelmina M., Hoofwijk, Anton G., and Ladies trial colloborators

Subjects
*COLON surgery, *IRRIGATION (Medicine), *LAPAROSCOPY, *PERITONITIS, *TREATMENT effectiveness, *INTESTINAL perforation, *COLON diverticulum, *DISEASE complications, *THERAPEUTICS
Abstract

Background: Case series suggest that laparoscopic peritoneal lavage might be a promising alternative to sigmoidectomy in patients with perforated diverticulitis. We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in patients with purulent perforated diverticulitis, with respect to overall long-term morbidity and mortality.Methods: We did a multicentre, parallel-group, randomised, open-label trial in 34 teaching hospitals and eight academic hospitals in Belgium, Italy, and the Netherlands (the Ladies trial). The Ladies trial is split into two groups: the LOLA group comparing laparoscopic lavage with sigmoidectomy and the DIVA group comparing Hartmann's procedure with sigmoidectomy plus primary anastomosis. The DIVA section of this trial is still underway but here we report the results of the LOLA section. Patients with purulent perforated diverticulitis were enrolled for LOLA, excluding patients with faecal peritonitis, aged older than 85 years, with high-dose steroid use (≥20 mg daily), and haemodynamic instability. Patients were randomly assigned (2:1:1; stratified by age [<60 years vs ≥60 years]) using secure online computer randomisation to laparoscopic lavage, Hartmann's procedure, or primary anastomosis in a parallel design after diagnostic laparoscopy. Patients were analysed according to a modified intention-to-treat principle and were followed up after the index operation at least once in the outpatient setting and after sigmoidoscopy and stoma reversal, according to local protocols. The primary endpoint was a composite endpoint of major morbidity and mortality within 12 months. This trial is registered with ClinicalTrials.gov, number NCT01317485.Findings: Between July 1, 2010, and Feb 22, 2013, 90 patients were randomly assigned in the LOLA section of the Ladies trial when the study was terminated by the data and safety monitoring board because of an increased event rate in the lavage group. Two patients were excluded for protocol violations. The primary endpoint occurred in 30 (67%) of 45 patients in the lavage group and 25 (60%) of 42 patients in the sigmoidectomy group (odds ratio 1·28, 95% CI 0·54-3·03, p=0·58). By 12 months, four patients had died after lavage and six patients had died after sigmoidectomy (p=0·43).Interpretation: Laparoscopic lavage is not superior to sigmoidectomy for the treatment of purulent perforated diverticulitis.Funding: Netherlands Organisation for Health Research and Development. [ABSTRACT FROM AUTHOR]

Published
2015
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22. Detection of colon cancer recurrences during follow-up care by general practitioners vs surgeons.

Author

Vos JAM, Sert E, Busschers WB, Duineveld LAM, Wieldraaijer T, Wind J, Donkervoort SC, Govaert MJPM, Beverdam FH, Smits AB, Bemelman WA, Heuff G, van Weert HCPM, and van Asselt KM

Subjects
Humans, Male, Aged, Female, Aftercare, Follow-Up Studies, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local epidemiology, General Practitioners, Colonic Neoplasms diagnosis, Colonic Neoplasms surgery, Surgeons
Abstract

Background: In the I CARE study, colon cancer patients were randomly assigned to receive follow-up care from either a general practitioner (GP) or a surgeon. Here, we address a secondary outcome, namely, detection of recurrences and effect on time to detection of transferring care from surgeon to GP., Methods: Pattern, stage, and treatment of recurrences were described after 3 years. Time to event was defined as date of surgery, until date of recurrence or last follow-up, with death as competing event. Effects on time to recurrence and death were estimated as hazard ratios (HRs) using Cox regression. Restricted mean survival times were estimated., Results: Of 303 patients, 141 were randomly assigned to the GP and 162 to the surgeon. Patients were male (67%) with a mean age of 68.0 (8.4) years. During follow-up, 46 recurrences were detected; 18 (13%) in the GP vs 28 (17%) in the surgeon group. Most recurrences were detected via abnormal follow-up tests (74%) and treated with curative intent (59%). Hazard ratio for recurrence was 0.75 (95% confidence interval [CI] = 0.41 to 1.36) in GP vs surgeon group. Patients in the GP group remained in the disease-free state slightly longer (2.76 vs 2.71 years). Of the patients, 38 died during follow-up; 15 (11%) in the GP vs 23 (14%) in the surgeon group. Of these, 21 (55%) deaths were related to colon cancer. There were no differences in overall deaths between the groups (HR = 0.76, 95% CI = 0.39 to 1.46)., Conclusion: Follow-up provided by GPs vs surgeons leads to similar detection of recurrences. Also, no differences in mortality were found., (© The Author(s) 2023. Published by Oxford University Press.)

Published
2023
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23. The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitis and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitis in perforated diverticulitis (NTR2037).

Author

Swank HA, Vermeulen J, Lange JF, Mulder IM, van der Hoeven JA, Stassen LP, Crolla RM, Sosef MN, Nienhuijs SW, Bosker RJ, Boom MJ, Kruyt PM, Swank DJ, Steup WH, de Graaf EJ, Weidema WF, Pierik RE, Prins HA, Stockmann HB, Tollenaar RA, van Wagensveld BA, Coene PP, Slooter GD, Consten EC, van Duijn EB, Gerhards MF, Hoofwijk AG, Karsten TM, Neijenhuis PA, Blanken-Peeters CF, Cense HA, Mannaerts GH, Bruin SC, Eijsbouts QA, Wiezer MJ, Hazebroek EJ, van Geloven AA, Maring JK, D'Hoore AJ, Kartheuser A, Remue C, van Grevenstein HM, Konsten JL, van der Peet DL, Govaert MJ, Engel AF, Reitsma JB, and Bemelman WA

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anastomosis, Surgical, Colectomy, Colostomy, Female, Humans, Intestinal Perforation etiology, Laparoscopy, Middle Aged, Peritonitis etiology, Treatment Outcome, Diverticulitis complications, Intestinal Perforation surgery, Peritoneal Lavage methods, Peritonitis surgery
Abstract

Background: Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy.The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis)., Methods/design: In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm). Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm). The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%). Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and power = 90%) in favour of the patients with resection with primary anastomosis. Secondary endpoints for both arms are the number of days alive and outside the hospital, health related quality of life, health care utilisation and associated costs., Discussion: The Ladies trial is a nationwide multicentre randomised trial on perforated diverticulitis that will provide evidence on the merits of laparoscopic lavage and drainage for purulent generalised peritonitis and on the optimal resectional strategy for both purulent and faecal generalised peritonitis., Trial Registration: Nederlands Trial Register NTR2037.

Published
2010
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