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433 results on '"Gower-Rousseau C"'

2. Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: a possible association with Lyme disease?

Author

Dupont, M, Carlier, Claire, Gower-Rousseau, C, Barbier-Lider, P, Botsen, D, Brasseur, M, Burgevin, A, Chourbagi, C, D’Almeida, R, Hautefeuille, V, Hentzien, M, Lambert, A, Lamuraglia, M, Lavau-Denes, S, Lopez, A, Parent, D, Slimano, F, Brugel, M, and Bouché, O

Published
2022
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7. P155 Natural history of anal stricture in pediatric-onset Crohn’s disease: a two-decades population-based study

Author

Mortreux, P, primary, Leroyer, A, additional, Ley, D, additional, Dupont-Lucas, C, additional, Bertrand, V, additional, Wils, P, additional, Coevoet, H, additional, Paupard, T, additional, Gower-Rousseau, C, additional, Siproudhis, L, additional, Guillon, N, additional, Sarter, H, additional, Savoye, G, additional, Turck, D, additional, and Fumery, M, additional

Published
2023
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9. P207 Colonic location at diagnosis of pediatric-onset Crohn’s disease is associated with a pejorative disease course: a two decades population-based study

Author

Fumery, Mathurin, Savoye, G, Ley, D, Dupont-Lucas, C, Bertrand, V, Wils, P, Guillon, N, Sarter, H, Gower-Rousseau, C, Turck, D, Leroyer, A, CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Groupe Hospitalier du Havre, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Maison Régionale de la Recherche Clinique [Lille], Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background Crohn's disease (CD) location would influence the risk of complications and therapeutic strategies. The objective of this study was to compare the clinical presentation at diagnosis and the natural history of colonic CD in comparison to ileal CD and ulcerative colitis (UC) in pediatric-onset inflammatory bowel disease. Methods All children (< 17 years) with a diagnosis of CD or UC made between 1988 and 2011 in a population-based registry were followed retrospectively until 2013. Presentation at diagnosis, risks of complicated disease, surgery, hospitalization and exposure to treatments in ileal CD (L1), colonic CD (L2) and UC were compared. Disease location was defined at diagnosis. In case of extension of the disease (L1 or L2 to L3), follow-up was censored. Results A total of 215 L1 patients, 234 L2 patients and 337 UC patients were included. At diagnosis, the proportion of males (L1 53.5%; L2 53.4%; UC 42.7%; p=0.012), age at diagnosis (15.0; 13.7; 14.0 years; p=0.003), family history of IBD (12.6%; 12.7%; 5.0%; p=0.005), diagnostic delay (3.0; 3.0; 2.0 months; p=0.001) and smoking prevalence (11.6%; 8.1%; 5.6%; p=0.041) were different between the three groups. Bloody stool and diarrhea at diagnosis was observed in respectively 14.9%, 44.4%, and 91.1% (p < 0.001) and 47.0%, 71.8%, and 65.0% (p < 0.001) of L1, L2 and UC. At diagnosis, granuloma was identified in 12.6% of L1 patients and 31.2% of L2 patients (p

Published
2023
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13. Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study

Author

Hochart, A, Gower-Rousseau, C, Sarter, H, Fumery, M, Ley, D, Spyckerelle, C, Peyrin-Biroulet, L, Laberenne, J-E, Vasseur, F, Savoye, G, Turck, D, Andre, JM, Antonietti, M, Aouakli, A, Armand, A, Aroichane, I, Assi, F, Aubet, JP, Auxenfants, E, Ayafi-Ramelot, F, Azzouzi, K, Bankovski, D, Barbry, B, Bardoux, N, Baron, P, Baudet, A, Bazin, B, Bebahani, A, Becqwort, JP, Benet, V, Benali, H, Benguigui, C, Ben Soussan, E, Bental, A, Berkelmans, I, Bernet, J, Bernou, K, Bernou-Dron, C, Bertot, P, Bertiaux-Vandaële, N, Bertrand, V, Billoud, E, Biron, N, Bismuth, B, Bleuet, M, Blondel, F, Blondin, V, Bohon, P, Boniface, E, Bonnière, P, Bonvarlet, E, Bonvarlet, P, Boruchowicz, A, Bostvironnois, R, Boualit, M, Bouche, B, Boudaillez, C, Bourgeaux, C, Bourgeois, M, Bourguet, A, Bourienne, A, Branche, J, Bray, G, Brazier, F, Breban, P, Bridenne, M, Brihier, H, Brung-Lefebvre, V, Bulois, P, Burgiere, P, Butel, J, Canva, JY, Canva-Delcambre, V, Capron, JP, Cardot, F, Carpentier, P, Cartier, E, Cassar, JF, Cassagnou, M, Castex, JF, Catala, P, Cattan, S, Catteau, S, Caujolle, B, Cayron, G, Chandelier, C, Chantre, M, Charles, J, Charneau, T, Chavance-Thelu, M, Chirita, D, Choteau, A, Claerbout, JF, Clergue, PY, Coevoet, H, Cohen, G, Collet, R, Colombel, JF, Coopman, S, Corvisart, J, Cortot, A, Couttenier, F, Crinquette, JF, Crombe, V, Dadamessi, I, Dapvril, V, Davion, T, Dautreme, S, Debas, J, Degrave, N, Dehont, F, Delatre, C, Delcenserie, R, Delette, O, Delgrange, T, Delhoustal, L, Delmotte, JS, Demmane, S, Deregnaucourt, G, Descombes, P, Desechalliers, JP, Desmet, P, Desreumaux, P, Desseaux, G, Desurmont, P, Devienne, A, Devouge, E, Devred, M, Devroux, A, Dewailly, A, Dharancy, S, Di Fiore, A, Djeddi, D, Djedir, R, Dreher-Duwat, ML, Dubois, R, Dubuque, C, Ducatillon, P, Duclay, J, Ducrocq, B, Ducrot, F, Ducrotte, P, Dufilho, A, Duhamel, C, Dujardin, D, Dumant-Forest, C, Dupas, JL, Dupont, F, Duranton, Y, Duriez, A, El Achkar, K, El Farisi, M, Elie, C, Elie-Legrand, MC, Elkhaki, A, Eoche, M, Evrard, D, Evrard, JP, Fatome, A, Filoche, B, Finet, L, Flahaut, M, Flamme, C, Foissey, D, Fournier, P, Foutrein-Comes, MC, Foutrein, P, Fremond, D, Frere, T, Gallet, P, Gamblin, C, Ganga, S, Gerard, R, Geslin, G, Gheyssens, Y, Ghossini, N, Ghrib, S, Gilbert, T, Gillet, B, Godard, D, Godard, P, Godchaux, JM, Godchaux, R, Goegebeur, G, Goria, O, Gottrand, F, Gower, P, Grandmaison, B, Groux, M, Guedon, C, Guillard, JF, Guillem, L, Guillemot, F, Guimberd, D, Haddouche, B, Hakim, S, Hanon, D, Hautefeuille, V, Heckestweiller, P, Hecquet, G, Hedde, JP, Hellal, H, Henneresse, PE, Heyman, B, Heraud, M, Herve, S, Hochain, P, Houssin-Bailly, L, Houcke, P, Huguenin, B, Iobagiu, S, Ivanovic, A, Iwanicki-Caron, I, Janicki, E, Jarry, M, Jeu, J, Joly, JP, Jonas, C, Katherin, F, Kerleveo, A, Khachfe, A, Kiriakos, A, Kiriakos, J, Klein, O, Kohut, M, Kornhauser, R, Koutsomanis, D, Laffineur, G, Lagarde, M, Lalanne, A, Lannoy, P, Lapchin, J, Laprand, M, Laude, D, Leblanc, R, Lecieux, P, Leclerc, N, Le Couteulx, C, Ledent, J, Lefebvre, J, Lefiliatre, P, Legrand, C, Le Grix, A, Lelong, P, Leluyer, B, Lenaerts, C, Lepileur, L, Leplat, A, Lepoutre-Dujardin, E, Leroi, H, Leroy, MY, Lesage, JP, Lesage, X, Lesage, J, Lescanne-Darchis, I, Lescut, J, Lescut, D, Leurent, B, Levy, P, Lhermie, M, Lion, A, Lisambert, B, Loire, F, Louf, S, Louvet, A, Luciani, M, Lucidarme, D, Lugand, J, Macaigne, O, Maetz, D, Maillard, D, Mancheron, H, Manolache, O, Marks-Brunel, AB, Marti, R, Martin, F, Martin, G, Marzloff, E, Mathurin, P, Mauillon, J, Maunoury, V, Maupas, JL, Mesnard, B, Metayer, P, Methari, L, Meurisse, B, Meurisse, F, Michaud, L, Mirmaran, X, Modaine, P, Monthe, A, Morel, L, Mortier, PE, Moulin, E, Mouterde, O, Mudry, J, Nachury, M, NʼGuyen Khac, E, Notteghem, B, Ollevier, V, Ostyn, A, Ouraghi, A, Ouvry, D, Paillot, B, Panien-Claudot, N, Paoletti, C, Papazian, A, Parent, B, Pariente, B, Paris, JC, Patrier, P, Paupart, L, Pauwels, B, Pauwels, M, Petit, R, Piat, M, Piotte, S, Plane, C, Plouvier, B, Pollet, E, Pommelet, P, Pop, D, Pordes, C, Pouchain, G, Prades, P, Prevost, A, Prevost, JC, Quesnel, B, Queuniet, AM, Quinton, JF, Rabache, A, Rabelle, P, Raclot, G, Ratajczyk, S, Rault, D, Razemon, V, Reix, N, Revillon, M, Richez, C, Robinson, P, Rodriguez, J, Roger, J, Roux, JM, Rudelli, A, Saber, A, Schlosseberg, P, Segrestin, M, Seguy, D, Serin, M, Seryer, A, Sevenet, F, Shekh, N, Silvie, J, Simon, V, Talbodec, N, Techy, A, Thelu, JL, Thevenin, A, Thiebault, H, Thomas, J, Thorel, JM, Tielman, G, Tode, M, Toisin, J, Tonnel, J, Touchais, JY, Touze, Y, Tranvouez, JL, Triplet, C, Uhlen, S, Vaillant, E, Valmage, C, Vanco, D, Vandamme, H, Vanderbecq, E, Vander Eecken, E, Vandermolen, P, Vandevenne, P, Vandeville, L, Vandewalle, A, Vandewalle, C, Vaneslander, P, Vanhoove, JP, Vanrenterghem, A, Varlet, P, Vasies, I, Verbiese, G, Vernier-Massouille, G, Vermelle, P, Verne, C, Vezilier-Cocq, P, Vigneron, B, Vincendet, M, Viot, J, Voiment, YM, Wacrenier, A, Waeghemaecker, L, Wallez, JY, Wantiez, M, Wartel, F, Weber, J, Willocquet, JL, Wizla, N, Wolschies, E, Zalar, A, Zaouri, B, Zellweger, A, and Ziade, C

Published
2017
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16. P734 The sex ratio of inflammatory bowel disease varies according to age at onset: results from a worldwide survey

Author

Shah, S.C., Khalili, H., Gower-Rousseau, C., Olén, O., Benchimol, E., Lynge, E., Nielsen, K., Ahn, H., Brassard, P., Vutcovici, M., Bitton, A., Bernstein, C., Leddin, D., Tamim, H., Aniwan, S., Chen, C.-Y., Stefánsson, T., Loftus, E.V., Jr., Moum, B., Tang, W., Ng, S., Gearry, R., Sincic, B., Bell, S., Lakatos, P.L., Végh, Z., Ott, C., Kaplan, G., Burisch, J., and Colombel, J.-F.

Published
2017
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19. Long-term effectiveness of anti-TNF therapy in pediatric-onset inflammatory bowel diseases: a population-based study

Author

Fumery, Mathurin, Savoye, G., Ley, D., Dupont, C., Bertrand, V., Spyckerelle, C., Guillon, N., Desreumaux, P., Gower-Rousseau, C., Sarter, H., Turck, D., Leroyer, A., CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Jeanne de Flandre [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Groupe Hospitalier du Havre, Unité Pédiatrique [Saint-Vincent de Paul Lille], Hôpital Saint-Vincent de Paul, Hôpital Claude Huriez [Lille], CHU Lille, Service d'Epidémiologie et de Santé Publique [Lille], Maison Régionale de la Recherche Clinique [Lille], Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Santé et de la Recherche Médicale (INSERM), and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

20. Natural history of anal ulcerations in pediatric-onset Crohn's Disease: A population-based study

Author

Mortreux, P., Leroyer, A., Dupont, C., Ley, D., Bertrand, V., Spyckerelle, C., Guillon, N., Desreumaux, P., Gower-Rousseau, C., Savoye, G., Fumery, Mathurin, Turck, D., Siproudhis, L., Sarter, H., DESSAIVRE, Louise, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Jeanne de Flandre [Lille], Université de Lille, Groupe Hospitalier du Havre, Unité Pédiatrique [Saint-Vincent de Paul Lille], Hôpital Saint-Vincent de Paul, Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Claude Huriez [Lille], CHU Lille, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), SFNCP, GREP, IHFIH UPRES EA 3859, Service d'Epidémiologie et de Santé Publique [Lille], and Maison Régionale de la Recherche Clinique [Lille]

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

22. OP35 Natural history of anal ulcerations in pediatric-onset Crohn’s Disease: A population-based study

Author

Mortreux, P, primary, Leroyer, A, additional, Dupont, C, additional, Ley, D, additional, Bertrand, V, additional, Spyckerelle, C, additional, Guillon, N, additional, Desreumaux, P, additional, Gower-Rousseau, C, additional, Savoye, G, additional, Fumery, M, additional, Turck, D, additional, Siproudhis, L, additional, and Sarter, H, additional

Published
2022
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24. Impact of therapeutic strategies on intestinal resection rate in paediatric inflammatory bowel diseases: A population-based cohort study over a 24-year period (1988-2011)

Author

Ley, D., Leroyer, A., Dupont, C., Sarter, H., Bertrand, V., Spyckerelle, C., Guillon, N., Pariente, B., Savoye, G., Turck, D., Gower-Rousseau, C., Fumery, Mathurin, Grp, Epimad, Hôpital Jeanne de Flandre [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d'Epidémiologie et de Santé Publique [Lille], Groupe Hospitalier du Havre, Unité Pédiatrique [Saint-Vincent de Paul Lille], Hôpital Saint-Vincent de Paul, Hôpital Claude Huriez [Lille], Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020
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25. The changing pattern of inflammatory bowel disease incidence in Northern France: A continuing increase in the young women (1988-2014)

Author

Cretin, T., Sarter, H., Savoye, G., Fumery, Mathurin, Leroyer, A., Dauchet, L., Pariente, B., Gower-Rousseau, C., Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maison Régionale de la Recherche Clinique [Lille], Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Hôpital Claude Huriez [Lille], and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

26. Opposite evolution in incidence of Crohn's disease and ulcerative colitis in Northern France (1988-1999)

Author

Molinie, F., Gower-Rousseau, C., Yzet, T., Merle, V., Grandbastien, B., Cortot, A., Salomez, J-L, Colombel, J-F, Dupas, J-L, Lerebours, E., and Marti, R.

Subjects
Ulcerative colitis -- Risk factors, Ulcerative colitis -- Care and treatment, Crohn's disease -- Risk factors, Crohn's disease -- Care and treatment, Health
Abstract

The trends in the incidence of inflammatory bowel disease (IBD) are examined over a period of 12 year from 1988 to 1999 in areas of Northern France. The incidence of Crohn's disease increased by 23 percent and the incidence of ulcerative colitis (UC) declined by 17 percent during the 12 years.

Published
2004

28. CARD4/NOD1 is not involved in inflammatory bowel disease. (Inflammatory Bowel Disease)

Author

Zouali, H., Lesage, S., Merlin, F., Cezard, J-P., Colombel, J-F., Belaiche, J., Almer, S., Tysk, C., O'Morain, C., Gassull, M., Christensen, S., Finkel, Y., Modigliani, R., Gower-Rousseau, C., Macry, J., Chamaillard, M., Thomas, G., and Hugot, J-P.

Subjects
Inflammatory bowel diseases -- Genetic aspects, Health
Abstract

Background and aims: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are complex genetic disorders. CARD15/NOD2, a member of the Ced4 super-family which includes Apaf-1 and [...]

Published
2003

31. OP02 Impact of therapeutic strategies on intestinal resection rate in paediatric inflammatory bowel diseases: A population-based cohort study over a 24-year period (1988–2011)

Author

Ley, D, primary, Leroyer, A, additional, Dupont, C, additional, Sarter, H, additional, Bertrand, V, additional, Spyckerelle, C, additional, Guillon, N, additional, Pariente, B, additional, Savoye, G, additional, Turck, D, additional, Gower-Rousseau, C, additional, and Fumery, M, additional

Published
2020
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32. A novel rare missense variation of the NOD2 gene: Evidences of implication in Crohn's Disease

Author

Frade-Proud'Hon-Clerc, S, Smol, T, Frenois, F, Sand, O, Vaillant, E, Dhennin, V, Bonnefond, A, Froguel, P, Fumery, M, Guillon-Dellac, N, Gower-Rousseau, C, and Vasseur, F

Subjects
SERVER, Crohn’s disease, Biochemistry & Molecular Biology, 0604 Genetics, Science & Technology, Chemical Physics, Chemistry, Multidisciplinary, 0699 Other Biological Sciences, NOD2 gene, SUSCEPTIBILITY, VARIANTS, Chemistry, Crohn's disease, ULCERATIVE-COLITIS, Physical Sciences, 0399 Other Chemical Sciences, WES, variation, Life Sciences & Biomedicine, MUTATION, INFLAMMATORY-BOWEL-DISEASE
Published
2019

33. Incidence of indeterminate colitis in the EPIMAD registry decreases over the period 1988-2014

Author

Mayer, P., Sarter, H., Fumery, Mathurin, Savoye, G., Leroyer, A., Dauchet, L., Gower-Rousseau, C., Pariente, B., Hôpital Claude Huriez [Lille], CHU Lille, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maison Régionale de la Recherche Clinique [Lille], CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; BackgroundInflammatory bowel disease unclassified (IBDU) represents 5–15% of new diagnosis of inflammatory bowel disease. However, IBDU is not well defined and high rate of reclassification in Crohn’s disease (CD) or Ulcerative colitis (UC) is observed during follow-up. The objective of the present study was to evaluate the evolution of the incidence of IBDU over the period 1988–2014 in a population-based study and its reclassification rate during the follow-up.MethodsAll adults (> 17 years old) patients diagnosed with IBDU according to a validated and published algorithm1 in the French population-based registry EPIMAD from 1988 to 2014, were identified. Follow-up was divided in 3 periods of 9 years (1988–1996, 1997–2005, and 2006–2014). Reclassification was defined as a modification of diagnosis during the follow-up.Results24 304 IBD cases (> 17 years) were diagnosed, including 8449 (66.2%) CD, 3839 (30.1%) UC and 476 (3.7%) IBDU. IBDU concerned predominantly males compared with CD and UC population [(51.7% in IBDU population (n = 246) vs. 45.6% in CD plus UC population (n = 5602) (p = 0.009)], with an older age at diagnosis [(36 [26–51] in IBDU population vs. 30 [28–42] in CD plus UC population (p < 0.001)]. IBDU rate among IBD diagnosis decreased significantly during the study period, from 6% (1988–1996) to 2% (2006–2014) (p < 0.0001). In the IBDU cohort, 334 (70.2%) only had one diagnosis; 132 (27.7%) had two and 10 (2.1%) had three during follow-up. IBDU reclassification occurred in 108 patients (22.7%). The median time for reclassification was 1 year (IQR [1 −2]) after the diagnosis. Eighty-nine patients (18.7%) were reclassified to CD or UC after a new flare. There was no significant modification of IBDU reclassification rate in CD or UC during the study period 17% (1988–1996) to 21% (2005–2014) (p = 0.56).ConclusionsIn this population-based study, IBDU incidence decreased significantly between 1988 and 2014, probably because of better diagnosis performances allowing CD and UC identification. These results suggest that IBDU may not be a real and significant clinical entity but a misclassification of colonic inflammatory bowel disease.

Published
2019
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34. Perianal lesions in Crohn's disease: analysis of Epimad registry from 2007 to 2012

Author

Wils, P., Leroyer, A., Fumery, Mathurin, Nistal, A. Fernandez, Bojic, D., d'Ambrosio, R., Sarter, H., Savoye, G., Gower-Rousseau, C., Pariente, B., Hôpital Claude Huriez [Lille], CHU Lille, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maison Régionale de la Recherche Clinique [Lille], Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019
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35. Fine-scale geographic distribution and ecological studies of Crohn's disease in France (2007-2014)

Author

Génin, M., Fumery, Mathurin, Occelli, F., Savoye, G., Pariente, B., Dauchet, L., Vignal, C., Body-Malapel, M., Giovannelli, J., Sarter, H., Gower-Rousseau, C., Ficheur, G., Santé Publique : épidémiologie et qualité des soins (EA 2694), Faculté de Médecine Henri Warembourg - Université de Lille-Centre d'Etudes et de Recherche en Informatique Médicale [Lille] (CERIM), Université de Lille, CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Claude Huriez [Lille], CHU Lille, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Lille Inflammation Research International Center - U 995 (LIRIC), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV]Life Sciences [q-bio], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Poster n° 741; International audience; BackgroundA significant geographical variation in the incidence of Crohn's disease (CD) suggests the role of environmental factors in its pathogenesis. The objectives of this work were (i) to study the spatial distribution of CD cases in France from the database of the Programme de Médicalisation des Systèmes d'Information (PMSI), (ii) to study the factors associated with spatial heterogeneity and (iii) to identify clusters of high-prevalence.MethodsPatients with a CD diagnostic code were searched in the PMSI database between 2007 and 2014. To study the spatial distribution of prevalence for this period, a fine-scale spatial unit (5610 units at the national level) was used. The results were expressed as standardised prevalence ratio (SPR). An ecological regression measured the association between the risk of CD and spatial unit characteristics, such as access to the nearest reference centre, urbanisation and rurality, deprivation index (FDep index), latitude, and distance from polluting facilities. Elliptical spatial scan statistics were used to search high-prevalence clusters.Results A total of 129089 patients with CD have been identified, with a national prevalence in 2014 of 203/100000 inhabitants. Significant spatial Geographical distribution of age-and-gender Standardised Prevalence Ratios of Crohn’s disease in France, 2007–2014. Conclusions: The French geographical distribution of CD is not uniformly distributed. Sixteen clusters with high-risk of CD have been identified. The poorest populations and industrialised areas were associated with a higher risk of developing CD.

Published
2019
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38. Impact of Extra-Intestinal Manifestations at Diagnosis on Disease Outcome in Pediatric- and Elderly-Onset Crohn′s Disease: A French Population-Based Study

Author

Duricova, Dana, Sarter, H., Savoye, G., Leroyer, A., Pariente, B., Armengol-Debeir, L., Bouguen, G., Ley, D., Turck, D., Templier, C., Buche, S., Peyrin-Biroulet, L., Gower-Rousseau, C., Fumery, Mathurin, CHU Amiens-Picardie, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maison Régionale de la Recherche Clinique [Lille], Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Hôpital Claude Huriez [Lille], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Jeanne de Flandre [Lille], Service d'Hépato-gastroentérologie [CHU Lille], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), and Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Publication dans un congrès; International audience

Published
2018
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42. Anticipation in familial Crohn's disease

Author

Grandbastien, B, Peeters, M, Franchimont, D, Gower-Rousseau, C, Speckel, D, Rutgeerts, P, Belaiche, J, Cortot, A, Vlietinck, R, and Colombel, J-F

Published
1998

43. Systematic review and meta-analysis:assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index

Author

Lo, B, Prosberg, M V, Gluud, L L, Chan, W, Leong, R W, van der List, E, van der Have, M, Sarter, H, Gower-Rousseau, C, Peyrin-Biroulet, L, Vind, I, Burisch, J, Lo, B, Prosberg, M V, Gluud, L L, Chan, W, Leong, R W, van der List, E, van der Have, M, Sarter, H, Gower-Rousseau, C, Peyrin-Biroulet, L, Vind, I, and Burisch, J

Abstract

BACKGROUND: The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed for patients with Crohn's disease (CD) and ulcerative colitis (UC).AIM: To assess the severity of disability and associated factors using the IBD-DI, and review the validity of the IBD-DI as a tool.METHOD: Systematic review of cross-sectional studies. Patients included had UC or CD and were classified as active, in remission, or needing surgery, biological and/or steroid treatment. We included studies assessing disability using the IBD-DI and that were captured by electronic and manual searches (January 2017). The possibility of bias was evaluated with the Newcastle-Ottawa Scale.RESULTS: Nine studies were included with 3167 patients. Comparatively, patients with active disease had higher disability rates than those in remission (SMD [CI95] = 1.49[1.11, 1.88], I(2) = 94%, P<.01), while patients on biological treatment had lower disability rates than those receiving corticosteroid treatment (SMD [CI95] = -0.22[-0.36, -0.08], I(2) = 0%, P<.01). Disease activity and unemployment were found to be associated factors. The IBD-DI scored "good" for internal consistency, "fair" to "excellent" for intra-rater reliability and "excellent" for inter-rater reliability. Construct validity was "moderately strong" to "very strong" and structural validity was found to be mainly unidimensional. The IBD-DI had excellent responsiveness, while its interpretability was only useful on a group level.CONCLUSIONS: This systematic review and meta-analysis found a significant association between disease activity, treatment received and disability; although significant heterogeneity was found. The IBD-DI is reliable and valid, but further studies are needed to measure its interpretability.

Published
2018

44. Diagnosing rare inherited disorders using targeted next generation sequencing in patients with early-onset inflammatory bowel disease: a population-based study

Author

Broly, F., Fumery, M., Vasseur, F., Savoye, G., Ley, D., Sarter, H., Dupas, J. L., Dominique Turck, Gower-Rousseau, C., CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Hôpital Jeanne de Flandre [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Hépato-gastroentérologie [CHU Lille], Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

48. P822 Impact of extra-intestinal manifestations at diagnosis on disease outcome in paediatric- and elderly-onset Crohn′s Disease: A French population-based study

Author

Duricová, D, primary, Sarter, H, additional, Savoye, G, additional, Leroyer, A, additional, Pariente, B, additional, Armengol-Debeir, L, additional, Bouguen, G, additional, Ley, D, additional, Turck, D, additional, Templier, C, additional, Buche, S, additional, Peyrin-Biroulet, L, additional, Gower-Rousseau, C, additional, and Fumery, M, additional

Published
2018
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49. Highlighting of epidemic areas of Crohn's disease in a population-based registry over 22 years: genetic or environmental cause?

Author

Genin, M., Cécile Vignal, Vasseur, F., Fumery, M., Savoye, G., Body-Malapel, M., Preda, C., Sarter, H., Peyrin-Biroulet, L., Desreumaux, P., Gower-Rousseau, C., Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Laboratoire Paul Painlevé (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Claude Huriez [Lille], and CHU Lille

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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50. Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index

Author

Lo, B., primary, Prosberg, M. V., additional, Gluud, L. L., additional, Chan, W., additional, Leong, R. W., additional, van der List, E., additional, van der Have, M., additional, Sarter, H., additional, Gower-Rousseau, C., additional, Peyrin-Biroulet, L., additional, Vind, I., additional, and Burisch, J., additional

Published
2017
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