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2. DenseNet and Support Vector Machine classifications of major depressive disorder using vertex-wise cortical features

Author

Belov, Vladimir, Erwin-Grabner, Tracy, Zeng, Ling-Li, Ching, Christopher R. K., Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Brosch, Katharina, Bülow, Robin, Colle, Romain, Connolly, Colm G., Corruble, Emmanuelle, Couvy-Duchesne, Baptiste, Cullen, Kathryn, Dannlowski, Udo, Davey, Christopher G., Dols, Annemiek, Ernsting, Jan, Evans, Jennifer W., Fisch, Lukas, Fuentes-Claramonte, Paola, Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke A., Grotegerd, Dominik, Hahn, Tim, Hamilton, J. Paul, Han, Laura K. M., Harrison, Ben J, Ho, Tiffany C., Jahanshad, Neda, Jamieson, Alec J., Karuk, Andriana, Kircher, Tilo, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Leenings, Ramona, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Meinert, Susanne, Melloni, Elisa, Mueller, Bryon A., Mwangi, Benson, Nenadić, Igor, Ojha, Amar, Okamoto, Yasumasa, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Radua, Joaquim, Rodríguez-Cano, Elena, Sacchet, Matthew D., Salvador, Raymond, Schrantee, Anouk, Sim, Kang, Soares, Jair C., Solanes, Aleix, Stein, Dan J., Stein, Frederike, Stolicyn, Aleks, Thomopoulos, Sophia I., Toenders, Yara J., Uyar-Demir, Aslihan, Vieta, Eduard, Vives-Gilabert, Yolanda, Völzke, Henry, Walter, Martin, Whalley, Heather C., Whittle, Sarah, Winter, Nils, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., and Goya-Maldonado, Roberto

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning, Quantitative Biology - Neurons and Cognition
Abstract

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, likely due to the heterogeneity of this disorder. The application of deep learning tools to neuroimaging data, capable of capturing complex non-linear patterns, has the potential to provide diagnostic and predictive biomarkers for MDD. However, previous attempts to demarcate MDD patients and healthy controls (HC) based on segmented cortical features via linear machine learning approaches have reported low accuracies. In this study, we used globally representative data from the ENIGMA-MDD working group containing an extensive sample of people with MDD (N=2,772) and HC (N=4,240), which allows a comprehensive analysis with generalizable results. Based on the hypothesis that integration of vertex-wise cortical features can improve classification performance, we evaluated the classification of a DenseNet and a Support Vector Machine (SVM), with the expectation that the former would outperform the latter. As we analyzed a multi-site sample, we additionally applied the ComBat harmonization tool to remove potential nuisance effects of site. We found that both classifiers exhibited close to chance performance (balanced accuracy DenseNet: 51%; SVM: 53%), when estimated on unseen sites. Slightly higher classification performance (balanced accuracy DenseNet: 58%; SVM: 55%) was found when the cross-validation folds contained subjects from all sites, indicating site effect. In conclusion, the integration of vertex-wise morphometric features and the use of the non-linear classifier did not lead to the differentiability between MDD and HC. Our results support the notion that MDD classification on this combination of features and classifiers is unfeasible.

Published
2023

3. Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures

Author

Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., and Goya-Maldonado, Roberto

Published
2024
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5. Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures

Author

Belov, Vladimir, Erwin-Grabner, Tracy, Gonul, Ali Saffet, Amod, Alyssa R., Ojha, Amar, Aleman, Andre, Dols, Annemiek, Scharntee, Anouk, Uyar-Demir, Aslihan, Harrison, Ben J, Irungu, Benson M., Besteher, Bianca, Klimes-Dougan, Bonnie, Penninx, Brenda W. J. H., Mueller, Bryon A., Zarate, Carlos, Davey, Christopher G., Ching, Christopher R. K., Connolly, Colm G., Fu, Cynthia H. Y., Stein, Dan J., Dima, Danai, Linden, David E. J., Mehler, David M. A., Pomarol-Clotet, Edith, Pozzi, Elena, Melloni, Elisa, Benedetti, Francesco, MacMaster, Frank P., Grabe, Hans J., Völzke, Henry, Gotlib, Ian H., Soares, Jair C., Evans, Jennifer W., Sim, Kang, Wittfeld, Katharina, Cullen, Kathryn, Reneman, Liesbeth, Oudega, Mardien L., Wright, Margaret J., Portella, Maria J., Sacchet, Matthew D., Li, Meng, Aghajani, Moji, Wu, Mon-Ju, Jaworska, Natalia, Jahanshad, Neda, van der Wee, Nic J. A., Groenewold, Nynke, Hamilton, Paul J., Saemann, Philipp, Bülow, Robin, Poletti, Sara, Whittle, Sarah, Thomopoulos, Sophia I., van, Steven J. A., Werff, der, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Ho, Tiffany C., Yang, Tony T., Basgoze, Zeynep, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., and Goya-Maldonado, Roberto

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (n=5,356) to provide a generalizable ML classification benchmark of major depressive disorder (MDD). Using brain measures from standardized ENIGMA analysis pipelines in FreeSurfer, we were able to classify MDD vs healthy controls (HC) with around 62% balanced accuracy, but when harmonizing the data using ComBat balanced accuracy dropped to approximately 52%. Similar results were observed in stratified groups according to age of onset, antidepressant use, number of episodes and sex. Future studies incorporating higher dimensional brain imaging/phenotype features, and/or using more advanced machine and deep learning methods may achieve more encouraging prospects., Comment: main document 37 pages; supplementary material 24 pages

Published
2022

7. Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Author

Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A, Arango, Celso, Arolt, Volker, Auzias, Guillaume, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Bandeira, Cibele, Başgöze, Zeynep, Cupertino, Renata Basso, Bau, Claiton HD, Bauer, Jochen, Baumeister, Sarah, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Brem, Silvia, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R, Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carmona, Susanna, Carr, Vaughan J, Catts, Stanley V, Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G, Conzelmann, Annette, Craven, Alexander R, Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Dannlowski, Udo, Davey, Christopher G, Deruelle, Christine, Díaz-Caneja, Covadonga M, Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T, Fedor, Jennifer, Fitzgerald, Jacqueline, Foran, William, Ford, Judith M, Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Gao, Bingchen, Gao, Si, Goikolea, Jose M, Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J, Green, Melissa, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Haavik, Jan, Hahn, Tim, Harrison, Ben J, Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J, Hilland, Eva, Hoekstra, Pieter J, Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M, Ipser, Jonathan C, Jahanshad, Neda, Jakobi, Babette, Jansen, Andreas, Janssen, Joost, Jonassen, Rune, Kaiser, Anna, Kaleda, Vasiliy, Karantonis, James, King, Joseph A, Kircher, Tilo, Kochunov, Peter, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, and Lawrie, Stephen

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Serious Mental Illness, Behavioral and Social Science, Genetics, Women's Health, Neurosciences, Schizophrenia, Brain Disorders, Preterm, Low Birth Weight and Health of the Newborn, Mental Health, Perinatal Period - Conditions Originating in Perinatal Period, Pregnancy, Pediatric, Mental Illness, Prevention, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Reproductive health and childbirth, Mental health, Neurological, Good Health and Well Being, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Bipolar Disorder, Cerebral Cortex, Child, Depressive Disorder, Major, Female, Humans, Infant, Newborn, Magnetic Resonance Imaging, Premature Birth, Cortical growth, Cortical surface area, Mental illness, Neurodevelopment, Neurogenesis, Psychiatric disorders, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences
Abstract

BackgroundMorphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.MethodsInterregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.ResultsAcross the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.ConclusionsOur findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Published
2022

12. Subject-Specific Resting-State Functional Connectivity to Personalize rTMS Interventions In Major Depressive Disorder

Author

Wilkening, Jonas, primary, Jungeblut, Henrike M., additional, Adamovic, Ivana, additional, Belov, Vladimir, additional, Dechent, Peter, additional, Eicke, Lara, additional, Hansen, Niels, additional, Kozyrev, Vladislav, additional, Marten, Lara E., additional, Muschke, Yonca, additional, Riemer, Caspar, additional, Schnell, Knut, additional, Tura, Asude, additional, Wilke, Melanie, additional, Witteler, Fabian, additional, Wiltfang, Jens, additional, Wunderlich, Anna, additional, Zimmeck, Valerie, additional, Zobott, Anna, additional, Schmidt-Samoa, Carsten, additional, Erwin-Grabner, Tracy, additional, and Goya-Maldonado, Roberto, additional

Published
2024
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13. Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

Author

Campos, Adrian I., Thompson, Paul M., Veltman, Dick J., Pozzi, Elena, van Veltzen, Laura S., Jahanshad, Neda, Adams, Mark J., Baune, Bernhard T., Berger, Klaus, Brosch, Katharina, Bülow, Robin, Connolly, Colm G., Dannlowski, Udo, Davey, Christopher G., de Zubicaray, Greig I., Dima, Danai, Erwin-Grabner, Tracy, Evans, Jennifer W., Fu, Cynthia H.Y., Gotlib, Ian H., Goya-Maldonado, Roberto, Grabe, Hans J., Grotegerd, Dominik, Harris, Matthew A., Harrison, Ben J., Hatton, Sean N., Hermesdorf, Marco, Hickie, Ian B., Ho, Tiffany C., Kircher, Tilo, Krug, Axel, Lagopoulos, Jim, Lemke, Hannah, McMahon, Katie, MacMaster, Frank P., Martin, Nicholas G., McIntosh, Andrew M., Medland, Sarah E., Meinert, Susanne, Meller, Tina, Nenadic, Igor, Opel, Nils, Redlich, Ronny, Reneman, Liesbeth, Repple, Jonathan, Sacchet, Matthew D., Schmitt, Simon, Schrantee, Anouk, Sim, Kang, Singh, Aditya, Stein, Frederike, Strike, Lachlan T., van der Wee, Nic J.A., van der Werff, Steven J.A., Völzke, Henry, Waltemate, Lena, Whalley, Heather C., Wittfeld, Katharina, Wright, Margaret J., Yang, Tony T., Zarate, Carlos A., Schmaal, Lianne, and Rentería, Miguel E.

Published
2021
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14. Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo.

Author

da Silva Correia, Angela, Schmitz, Matthias, Fischer, Anna‐Lisa, da Silva Correia, Susana, Simonetti, Franco L., Saher, Gesine, Goya‐Maldonado, Roberto, Arora, Amandeep Singh, Fischer, Andre, Outeiro, Tiago F., and Zerr, Inga

Abstract

INTRODUCTION: Cellular prion protein (PrPC) was implicated in amyloid beta (Aβ)‐induced toxicity in Alzheimer's disease (AD), but the precise molecular mechanisms involved in this process are unclear. METHODS: Double transgenic mice were generated by crossing Prnp knockout (KO) with 5xFAD mice, and light‐sheet microscopy was used for whole brain tissue analyses. PrPC‐overexpressing cells were developed for in vitro studies, and microscopy was used to assess co‐localization of proteins of interest. Surface‐plasmon resonance (SPR) was used to investigate protein‐binding characteristics. RESULTS: In vivo, PrPC levels correlated with reduced lifespan and cognitive and motor function, and its ablation disconnected behavior deficits from Aβ levels. Light‐sheet microscopy showed that PrPC influenced Aβ‐plaque burden but not the distribution of those plaques. Interestingly, caveolin‐1 (Cav‐1) KO neurons significantly reduced intracellular Aβ‐oligomer (Aβo) uptake when compared to wild‐type neurons. DISCUSSION: The findings shed new light on the relevance of intracellular Aβo, suggesting that PrPC and Cav‐1 modulate intracellular Aβ levels and the Aβ‐plaque load. Highlights: PrPC expression adversely affects lifespan and behavior in 5xFAD mice.PrPC increases Aβ1‐40 and Aβ1‐42 levels and Aβ‐plaque load in 5xFAD mice.Cav‐1 interacts with both PrPC and Aβ peptides.Knocking out Cav‐1 leads to a significant reduction in intracellular Aβ levels. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Reactivity of the Reward System in Artists during Acceptance and Rejection of Monetary Rewards

Author

Goya-Maldonado, Roberto, Keil, Maria, Brodmann, Katja, and Gruber, Oliver

Abstract

Humans possess an invaluable ability of self-expression that extends into visual, literary, musical, and many other fields of creation. More than any other profession, artists are in close contact with this subdomain of creativity. Probably one of the most intriguing aspects of creativity is its negative correlation with the availability of monetary reward. The aim of this study was to investigate the reactivity of the dopaminergic reward system in artists and nonartist controls using the desire-reason-dilemma (DRD) paradigm, which allows separate evaluation of reactivity to the acceptance and rejection of rewards. Using fMRI, blood-oxygen-level-dependent (BOLD) responses were measured in key regions of the reward system, namely the ventral striatum (VS), the ventral tegmental area (VTA), and the anterior ventral prefrontal cortex (AVPFC). In contrast to controls, artists presented significantly weaker VS activation in reward acceptance. Additionally, they showed stronger suppression of the VS by the AVPFC in reward rejection. No other differences in demographic or behavioral data were evidenced. These results support the existence of characteristic neural traits in artists, who display reduced reactions to monetary reward acceptance and increased reactions to monetary reward rejection.

Published
2018
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17. ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Author

Schmaal, Lianne, Pozzi, Elena, C. Ho, Tiffany, van Velzen, Laura S., Veer, Ilya M., Opel, Nils, Van Someren, Eus J. W., Han, Laura K. M., Aftanas, Lybomir, Aleman, André, Baune, Bernhard T., Berger, Klaus, Blanken, Tessa F., Capitão, Liliana, Couvy-Duchesne, Baptiste, R. Cullen, Kathryn, Dannlowski, Udo, Davey, Christopher, Erwin-Grabner, Tracy, Evans, Jennifer, Frodl, Thomas, Fu, Cynthia H. Y., Godlewska, Beata, Gotlib, Ian H., Goya-Maldonado, Roberto, Grabe, Hans J., Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gutman, Boris A., Hall, Geoffrey B., Harrison, Ben J., Hatton, Sean N., Hermesdorf, Marco, Hickie, Ian B., Hilland, Eva, Irungu, Benson, Jonassen, Rune, Kelly, Sinead, Kircher, Tilo, Klimes-Dougan, Bonnie, Krug, Axel, Landrø, Nils Inge, Lagopoulos, Jim, Leerssen, Jeanne, Li, Meng, Linden, David E. J., MacMaster, Frank P., M. McIntosh, Andrew, Mehler, David M. A., Nenadić, Igor, Penninx, Brenda W. J. H., Portella, Maria J., Reneman, Liesbeth, Rentería, Miguel E., Sacchet, Matthew D., G. Sämann, Philipp, Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Tozzi, Leonardo, van Der Wee, Nic J. A., van Tol, Marie-José, Vermeiren, Robert, Vives-Gilabert, Yolanda, Walter, Henrik, Walter, Martin, Whalley, Heather C., Wittfeld, Katharina, Whittle, Sarah, Wright, Margaret J., Yang, Tony T., Zarate, Jr, Carlos, Thomopoulos, Sophia I., Jahanshad, Neda, Thompson, Paul M., and Veltman, Dick J.

Published
2020
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19. Accelerated intermittent theta burst stimulation for major depressive disorder or bipolar depression: a systematic review and meta-analysis

Author

Cai, Dong-Bin, primary, Qin, Zhen-Juan, additional, Lan, Xian-Jun, additional, Liu, Qi-Man, additional, Qin, Xiu-De, additional, Jian-Jun, Wang, additional, Goya-Maldonado, Roberto, additional, Huang, Xing-Bing, additional, Ungvari, Gabor S., additional, Ng, Chee H., additional, Zheng, Wei, additional, and Xiang, Yu-Tao, additional

Published
2023
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21. Accelerated intermittent theta burst stimulation in major depressive disorder: A systematic review

Author

Acuut & Intensieve Zorg Med., Brain, Neuteboom, Daan, Zantvoord, Jasper B, Goya-Maldonado, Roberto, Wilkening, Jonas, Dols, Annemieke, van Exel, Eric, Lok, Anja, de Haan, Lieuwe, Scheepstra, Karel W F, Acuut & Intensieve Zorg Med., Brain, Neuteboom, Daan, Zantvoord, Jasper B, Goya-Maldonado, Roberto, Wilkening, Jonas, Dols, Annemieke, van Exel, Eric, Lok, Anja, de Haan, Lieuwe, and Scheepstra, Karel W F

Published
2023

23. Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.

Author

Campos, Adrian I., primary, Van Velzen, Laura S., additional, Veltman, Dick J., additional, Pozzi, Elena, additional, Ambrogi, Sonia, additional, Ballard, Elizabeth D., additional, Banaj, Nerisa, additional, Başgöze, Zeynep, additional, Bellow, Sophie, additional, Benedetti, Francesco, additional, Bollettini, Irene, additional, Brosch, Katharina, additional, Canales-Rodríguez, Erick J., additional, Clarke-Rubright, Emily K., additional, Colic, Lejla, additional, Connolly, Colm G., additional, Courtet, Philippe, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Dauvermann, Maria R., additional, Davey, Christopher G., additional, Deverdun, Jeremy, additional, Dohm, Katharina, additional, Erwin-Grabner, Tracy, additional, Goya-Maldonado, Roberto, additional, Fani, Negar, additional, Fortea, Lydia, additional, Fuentes-Claramonte, Paola, additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Grotegerd, Dominik, additional, Harris, Mathew A., additional, Harrison, Ben J., additional, Haswell, Courtney C., additional, Hawkins, Emma L., additional, Hill, Dawson, additional, Hirano, Yoshiyuki, additional, Ho, Tiffany C., additional, Jollant, Fabrice, additional, Jovanovic, Tanja, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, le Bars, Emmanuelle, additional, Lochner, Christine, additional, McIntosh, Andrew M., additional, Meinert, Susanne, additional, Mekawi, Yara, additional, Melloni, Elisa, additional, Mitchell, Philip, additional, Morey, Rajendra A., additional, Nakagawa, Akiko, additional, Nenadić, Igor, additional, Olié, Emilie, additional, Pereira, Fabricio, additional, Phillips, Rachel D., additional, Piras, Fabrizio, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Ressler, Kerry J., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Sacchet, Matthew D., additional, Salvador, Raymond, additional, Sandu, Anca-Larisa, additional, Shimizu, Eiji, additional, Singh, Aditya, additional, Spalletta, Gianfranco, additional, Steele, J. Douglas, additional, Stein, Dan J., additional, Stein, Frederike, additional, Stevens, Jennifer S., additional, Teresi, Giana I., additional, Uyar-Demir, Aslihan, additional, van der Wee, Nic J., additional, van der Werff, Steven J., additional, van Rooij, Sanne J. H., additional, Vecchio, Daniela, additional, Verdolini, Norma, additional, Vieta, Eduard, additional, Waiter, Gordon D., additional, Whalley, Heather, additional, Whittle, Sarah L., additional, Yang, Tony T., additional, Zarate, Carlos A., additional, Thompson, Paul M., additional, Jahanshad, Neda, additional, van Harmelen, Anne-Laura, additional, Blumberg, Hilary P., additional, Schmaal, Lianne, additional, and Rentería, Miguel E., additional

Published
2023
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24. Imaging Cognition

Author

Goya-Maldonado, Roberto, Gruber, Oliver, Mulert, Christoph, editor, and Shenton, Martha E., editor

Published
2014
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26. A large-scale ENIGMA multisite replication study of brain age in depression

Author

Han, Laura K.M., primary, Dinga, Richard, additional, Leenings, Ramona, additional, Hahn, Tim, additional, Cole, James H., additional, Aftanas, Lyubomir I., additional, Amod, Alyssa R., additional, Besteher, Bianca, additional, Colle, Romain, additional, Corruble, Emmanuelle, additional, Couvy-Duchesne, Baptiste, additional, Danilenko, Konstantin V., additional, Fuentes-Claramonte, Paola, additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Goya-Maldonado, Roberto, additional, Groenewold, Nynke A., additional, Hamilton, Paul, additional, Ichikawa, Naho, additional, Ipser, Jonathan C., additional, Itai, Eri, additional, Koopowitz, Sheri-Michelle, additional, Li, Meng, additional, Okada, Go, additional, Okamoto, Yasumasa, additional, Churikova, Olga S., additional, Osipov, Evgeny A., additional, Penninx, Brenda W.J.H., additional, Pomarol-Clotet, Edith, additional, Rodríguez-Cano, Elena, additional, Sacchet, Matthew D., additional, Shinzato, Hotaka, additional, Sim, Kang, additional, Stein, Dan J., additional, Uyar-Demir, Aslihan, additional, Veltman, Dick J., additional, and Schmaal, Lianne, additional

Published
2022
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28. Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression

Author

Hellmann-Regen, Julian, primary, Clemens, Vera, additional, Grözinger, Michael, additional, Kornhuber, Johannes, additional, Reif, Andreas, additional, Prvulovic, David, additional, Goya-Maldonado, Roberto, additional, Wiltfang, Jens, additional, Gruber, Oliver, additional, Schüle, Cornelius, additional, Padberg, Frank, additional, Ising, Marcus, additional, Uhr, Manfred, additional, Friede, Tim, additional, Huber, Cynthia, additional, Manook, André, additional, Baghai, Thomas C., additional, Rupprecht, Rainer, additional, and Heuser, Isabella, additional

Published
2022
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29. A Large-Scale ENIGMA Multisite Replication Study of Brain Age in Depression

Author

Han, Laura KM, primary, Dinga, Richard, additional, Leenings, Ramona, additional, Hahn, Tim, additional, Cole, James, additional, Aftanas, Lyubomir, additional, Amod, Alyssa, additional, Besteher, Bianca, additional, Colle, Romain, additional, Corruble, Emmanuelle, additional, Couvy-Duchesne, Baptiste, additional, Danilenko, Konstantin, additional, Fuentes-Claramonte, Paola, additional, Saffet Gonul, Ali, additional, Gotlib, Ian, additional, Goya-Maldonado, Roberto, additional, Groenewold, Nynke, additional, Hamilton, Paul, additional, Ichikawa, Naho, additional, Ipser, Jonathan, additional, Itai, Eri, additional, Koopowitz, Sheri-Michelle, additional, Li, Meng, additional, Okada, Go, additional, Okamoto, Yasumasa, additional, Olga, Churikova, additional, Osipov, Evgeny, additional, Penninx, Brenda, additional, Pomarol-Clotet, Edith, additional, Rogriguez-Cano, Elena, additional, Sacchet, Matthew, additional, Shinzato, Hotaka, additional, Sim, Kang, additional, Stein, Dan, additional, Uyar-Demir, Aslihan, additional, Veltman, Dick, additional, and Schmaal, Lianne, additional

Published
2022
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30. The role of educational attainment and brain morphology in major depressive disorder: Findings from the ENIGMA major depressive disorder consortium.

Author

Whittle, Sarah, primary, Rakesh, Divyangana, additional, Schmaal, Lianne, additional, Veltman, Dick J., additional, Thompson, Paul M., additional, Singh, Aditya, additional, Gonul, Ali Saffet, additional, Aleman, Andre, additional, Uyar Demir, Aslıhan, additional, Krug, Axel, additional, Mwangi, Benson, additional, Krämer, Bernd, additional, Baune, Bernhard T., additional, Stein, Dan J., additional, Grotegerd, Dominik, additional, Pomarol-Clotet, Edith, additional, Rodríguez-Cano, Elena, additional, Melloni, Elisa, additional, Benedetti, Francesco, additional, Stein, Frederike, additional, Grabe, Hans J., additional, Völzke, Henry, additional, Gotlib, Ian H., additional, Nenadić, Igor, additional, Soares, Jair C., additional, Repple, Jonathan, additional, Sim, Kang, additional, Brosch, Katharina, additional, Wittfeld, Katharina, additional, Berger, Klaus, additional, Hermesdorf, Marco, additional, Portella, Maria J., additional, Sacchet, Matthew D., additional, Wu, Mon-Ju, additional, Opel, Nils, additional, Groenewold, Nynke A., additional, Gruber, Oliver, additional, Fuentes-Claramonte, Paola, additional, Salvador, Raymond, additional, Goya-Maldonado, Roberto, additional, Sarró, Salvador, additional, Poletti, Sara, additional, Meinert, Susanne L., additional, Kircher, Tilo, additional, Dannlowski, Udo, additional, and Pozzi, Elena, additional

Published
2022
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33. Virtual ontogeny of cortical growth preceding mental illness

Author

German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, Grotegerd, Dominik., German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, and Grotegerd, Dominik.

Abstract

[Background]: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life., [Methods]: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed., [Results]: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth., [Conclusions]: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Published
2022

37. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

Author

Committee, Writing, Disorder, Autism Spectrum, French, Leon, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Guerrero-Pedraza, Amalia, Gur, Raquel E, Gur, Ruben C, Haar, Shlomi, Haarman, Bartholomeus C M, Thomopoulos, Sophia I, Haavik, Jan, Hahn, Tim, Hajek, Tomas, Harrison, Benjamin J, Harrison, Neil A, Hartman, Catharina A, Whalley, Heather C, Heslenfeld, Dirk J, Hibar, Derrek P, Hilland, Eva, Pozzi, Elena, Hirano, Yoshiyuki, Ho, Tiffany C, Hoekstra, Pieter J, Hoekstra, Liesbeth, Hohmann, Sarah, Hong, L. E., Höschl, Cyril, Høvik, Marie F, Howells, Fleur M, Nenadic, Igor, Abe, Yoshinari, Jalbrzikowski, Maria, James, Anthony C, Janssen, Joost, Jaspers-Fayer, Fern, Xu, Jian, Jonassen, Rune, Karkashadze, Georgii, King, Joseph A, Kircher, Tilo, Kirschner, Matthias, Abé, Christoph, Koch, Kathrin, Kochunov, Peter, Kohls, Gregor, Konrad, Kerstin, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Kwon, Jun Soo, Landén, Mikael, Landrø, Nils I, Anticevic, Alan, Lazaro, Luisa, Lebedeva, Irina S, Leehr, Elisabeth J, Lera-Miguel, Sara, Lesch, Klaus-Peter, Lochner, Christine, Louza, Mario R, Luna, Beatriz, Lundervold, Astri J, MacMaster, Frank P, Alda, Martin, Maglanoc, Luigi A, Malpas, Charles B, Portella, Maria J, Marsh, Rachel, Martyn, Fiona M, Mataix-Cols, David, Mathalon, Daniel H, McCarthy, Hazel, McDonald, Colm, McPhilemy, Genevieve, Aleman, Andre, Meinert, Susanne, Menchón, José M, Minuzzi, Luciano, Mitchell, Philip B, Moreno, Carmen, Morgado, Pedro, Muratori, Filippo, Murphy, Clodagh M, Murphy, Declan, Mwangi, Benson, Alloza, Clara, Nabulsi, Leila, Nakagawa, Akiko, Nakamae, Takashi, Namazova, Leyla, Narayanaswamy, Janardhanan, Jahanshad, Neda, Nguyen, Danai D, Nicolau, Rosa, O'Gorman Tuura, Ruth L, O'Hearn, Kirsten, Alonso-Lana, Silvia, Oosterlaan, Jaap, Opel, Nils, Ophoff, Roel A, Oranje, Bob, García de la Foz, Victor Ortiz, Overs, Bronwyn J, Paloyelis, Yannis, Pantelis, Christos, Parellada, Mara, Pauli, Paul, Disorder, Bipolar, Ameis, Stephanie H, Picó-Pérez, Maria, Picon, Felipe A, Piras, Fabrizio, Piras, Federica, Plessen, Kerstin J, Pomarol-Clotet, Edith, Preda, Adrian, Puig, Olga, Quidé, Yann, Radua, Joaquim, Anagnostou, Evdokia, Ramos-Quiroga, J Antoni, Rasser, Paul E, Rauer, Lisa, Reddy, Janardhan, Redlich, Ronny, Reif, Andreas, Reneman, Liesbeth, Repple, Jonathan, Retico, Alessandra, Richarte, Vanesa, McIntosh, Andrew A, Richter, Anja, Rosa, Pedro G P, Rubia, Katya K, Hashimoto, Ryota, Sacchet, Matthew D, Salvador, Raymond, Santonja, Javier, Sarink, Kelvin, Sarró, Salvador, Satterthwaite, Theodore D, Arango, Celso, Sawa, Akira, Schall, Ulrich, Schofield, Peter R, Schrantee, Anouk, Seitz, Jochen, Serpa, Mauricio H, Setién-Suero, Esther, Shaw, Philip, Shook, Devon, Silk, Tim J, Arnold, Paul D, Sim, Kang, Simon, Schmitt, Simpson, Helen Blair, Singh, Aditya, Skoch, Antonin, Skokauskas, Norbert, Soares, Jair C, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Asherson, Philip, Spaniel, Filip, Lawrie, Stephen M, Stern, Emily R, Stewart, S Evelyn, Takayanagi, Yoichiro, Temmingh, Henk S, Tolin, David F, Tomecek, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Assogna, Francesca, Uhlmann, Anne, van Amelsvoort, Therese, van der Wee, Nic J A, van der Werff, Steven J A, van Haren, Neeltje E M, van Wingen, Guido A, Vance, Alasdair, Vázquez-Bourgon, Javier, Vecchio, Daniela, Venkatasubramanian, Ganesan, Auzias, Guillaume, Vieta, Eduard, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Völzke, Henry, von Polier, Georg G, Walton, Esther, Weickert, Thomas W, Weickert, Cynthia Shannon, Weideman, Andrea S, Ayesa-Arriola, Rosa, Wittfeld, Katharina, Wolf, Daniel H, Wu, Mon-Ju, Yang, T. T., Yang, Sikun, Yoncheva, Yuliya, Yun, Je-Yeon, Cheng, Yuqi, Zanetti, Marcus V, Ziegler, Georg C, Bakker, Geor, Franke, Barbara, Hoogman, Martine, Buitelaar, Jan K, van Rooij, Daan, Andreassen, Ole A, Ching, Christopher R K, Veltman, Dick J, Schmaal, Lianne, Stein, Dan J, van den Heuvel, Odile A, Disorder, Major Depressive, Banaj, Nerisa, Turner, Jessica A, van Erp, Theo G M, Pausova, Zdenka, Thompson, Paul M, Paus, Tomáš, Attention-Deficit/Hyperactivity Disorder, Banaschewski, Tobias, Bandeira, Cibele E, Baranov, Alexandr, Bargalló, Núria, Bau, Claiton H D, Baumeister, Sarah, Baune, Bernhard T, Bellgrove, Mark A, Benedetti, Francesco, Disorder, Obsessive-Compulsive, Bertolino, Alessandro, Boedhoe, Premika S W, Boks, Marco, Bollettini, Irene, Del Mar Bonnin, Caterina, Borgers, Tiana, Borgwardt, Stefan, Brandeis, Daniel, Brennan, Brian P, Bruggemann, Jason M, Groups, Schizophrenia ENIGMA Working, Bülow, Robin, Busatto, Geraldo F, Calderoni, Sara, Calhoun, Vince D, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carr, Vaughan J, Cascella, Nicola, Cercignani, Mara, Patel, Yash, Chaim-Avancini, Tiffany M, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Crespo-Facorro, Benedicto, Cubillo, Ana I, Cullen, Kathryn R, Cupertino, Renata B, Daly, Eileen, Dannlowski, Udo, Parker, Nadine, Davey, Christopher G, Denys, Damiaan, Deruelle, Christine, Di Giorgio, Annabella, Dickie, Erin W, Dima, Danai, Dohm, Katharina, Ehrlich, Stefan, Ely, Benjamin A, Erwin-Grabner, Tracy, Shin, Jean, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas, Faraone, Stephen V, Fatjó-Vilas, Mar, Fedor, Jennifer M, Fitzgerald, Kate D, Ford, Judith M, Frodl, Thomas, Fu, Cynthia H Y, Howard, Derek, Fullerton, Janice M, Gabel, Matt C, Glahn, David C, Roberts, Gloria, Gogberashvili, Tinatin, Goikolea, Jose M, Gotlib, Ian H, Goya-Maldonado, Roberto, Grabe, Hans, Green, Melissa J, Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S. I., Pozzi, E., Abe, Y., Abe, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., Ameis, S. H., Anagnostou, E., Mcintosh, A. A., Arango, C., Arnold, P. D., Asherson, P., Assogna, F., Auzias, G., Ayesa-Arriola, R., Bakker, G., Banaj, N., Banaschewski, T., Bandeira, C. E., Baranov, A., Bargallo, N., Bau, C. H. D., Baumeister, S., Baune, B. T., Bellgrove, M. A., Benedetti, F., Bertolino, A., Boedhoe, P. S. W., Boks, M., Bollettini, I., Del Mar Bonnin, C., Borgers, T., Borgwardt, S., Brandeis, D., Brennan, B. P., Bruggemann, J. M., Bulow, R., Busatto, G. F., Calderoni, S., Calhoun, V. D., Calvo, R., Canales-Rodriguez, E. J., Cannon, D. M., Carr, V. J., Cascella, N., Cercignani, M., Chaim-Avancini, T. M., Christakou, A., Coghill, D., Conzelmann, A., Crespo-Facorro, B., Cubillo, A. I., Cullen, K. R., Cupertino, R. B., Daly, E., Dannlowski, U., Davey, C. G., Denys, D., Deruelle, C., Di Giorgio, A., Dickie, E. W., Dima, D., Dohm, K., Ehrlich, S., Ely, B. A., Erwin-Grabner, T., Ethofer, T., Fair, D. A., Fallgatter, A. J., Faraone, S. V., Fatjo-Vilas, M., Fedor, J. M., Fitzgerald, K. D., Ford, J. M., Frodl, T., Fu, C. H. Y., Fullerton, J. M., Gabel, M. C., Glahn, D. C., Roberts, G., Gogberashvili, T., Goikolea, J. M., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Green, M. J., Grevet, E. H., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Guerrero-Pedraza, A., Gur, R. E., Gur, R. C., Haar, S., Haarman, B. C. M., Haavik, J., Hahn, T., Hajek, T., Harrison, B. J., Harrison, N. A., Hartman, C. A., Whalley, H. C., Heslenfeld, D. J., Hibar, D. P., Hilland, E., Hirano, Y., Ho, T. C., Hoekstra, P. J., Hoekstra, L., Hohmann, S., Hong, L. E., Hoschl, C., Hovik, M. F., Howells, F. M., Nenadic, I., Jalbrzikowski, M., James, A. C., Janssen, J., Jaspers-Fayer, F., Xu, J., Jonassen, R., Karkashadze, G., King, J. A., Kircher, T., Kirschner, M., Koch, K., Kochunov, P., Kohls, G., Konrad, K., Kramer, B., Krug, A., Kuntsi, J., Kwon, J. S., Landen, M., Landro, N. I., Lazaro, L., Lebedeva, I. S., Leehr, E. J., Lera-Miguel, S., Lesch, K. -P., Lochner, C., Louza, M. R., Luna, B., Lundervold, A. J., Macmaster, F. P., Maglanoc, L. A., Malpas, C. B., Portella, M. J., Marsh, R., Martyn, F. M., Mataix-Cols, D., Mathalon, D. H., Mccarthy, H., Mcdonald, C., Mcphilemy, G., Meinert, S., Menchon, J. M., Minuzzi, L., Mitchell, P. B., Moreno, C., Morgado, P., Muratori, F., Murphy, C. M., Murphy, D., Mwangi, B., Nabulsi, L., Nakagawa, A., Nakamae, T., Namazova, L., Narayanaswamy, J., Jahanshad, N., Nguyen, D. D., Nicolau, R., O'Gorman Tuura, R. L., O'Hearn, K., Oosterlaan, J., Opel, N., Ophoff, R. A., Oranje, B., Garcia De La Foz, V. O., Overs, B. J., Paloyelis, Y., Pantelis, C., Parellada, M., Pauli, P., Pico-Perez, M., Picon, F. A., Piras, F., Plessen, K. J., Pomarol-Clotet, E., Preda, A., Puig, O., Quide, Y., Radua, J., Ramos-Quiroga, J. A., Rasser, P. E., Rauer, L., Reddy, J., Redlich, R., Reif, A., Reneman, L., Repple, J., Retico, A., Richarte, V., Richter, A., Rosa, P. G. P., Rubia, K. K., Hashimoto, R., Sacchet, M. D., Salvador, R., Santonja, J., Sarink, K., Sarro, S., Satterthwaite, T. D., Sawa, A., Schall, U., Schofield, P. R., Schrantee, A., Seitz, J., Serpa, M. H., Setien-Suero, E., Shaw, P., Shook, D., Silk, T. J., Sim, K., Simon, S., Simpson, H. B., Singh, A., Skoch, A., Skokauskas, N., Soares, J. C., Soreni, N., Soriano-Mas, C., Spalletta, G., Spaniel, F., Lawrie, S. M., Stern, E. R., Stewart, S. E., Takayanagi, Y., Temmingh, H. S., Tolin, D. F., Tomecek, D., Tordesillas-Gutierrez, D., Tosetti, M., Uhlmann, A., Van Amelsvoort, T., Van Der Wee, N. J. A., Van Der Werff, S. J. A., Van Haren, N. E. M., Van Wingen, G. A., Vance, A., Vazquez-Bourgon, J., Vecchio, D., Venkatasubramanian, G., Vieta, E., Vilarroya, O., Vives-Gilabert, Y., Voineskos, A. N., Volzke, H., Von Polier, G. G., Walton, E., Weickert, T. W., Weickert, C. S., Weideman, A. S., Wittfeld, K., Wolf, D. H., Wu, M. -J., Yang, T. T., Yang, K., Yoncheva, Y., Yun, J. -Y., Cheng, Y., Zanetti, M. V., Ziegler, G. C., Franke, B., Hoogman, M., Buitelaar, J. K., Van Rooij, D., Andreassen, O. A., Ching, C. R. K., Veltman, D. J., Schmaal, L., Stein, D. J., Van Den Heuvel, O. A., Turner, J. A., Van Erp, T. G. M., Pausova, Z., Thompson, P. M., Paus, T., Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Pediatric surgery, Radiology and nuclear medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Med Staf Spec Psychiatrie (9), Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, General Paediatrics, ARD - Amsterdam Reproduction and Development, Radiology and Nuclear Medicine, APH - Personalized Medicine, ANS - Brain Imaging, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, University of Zurich, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Child and Adolescent Psychiatry / Psychology, IBBA, and Cognitive Psychology

Subjects
Male, Obsessive-Compulsive Disorder, Bipolar Disorder, Autism Spectrum Disorder, Autism, [SDV]Life Sciences [q-bio], Gene Expression, cytology [Cerebral Cortex], Cohort Studies, Fetal Development, physiology [Gene Expression], 2738 Psychiatry and Mental Health, 0302 clinical medicine, diagnostic imaging [Cerebral Cortex], SCHIZOPHRENIA, BRAIN, Child, Obsessive-compulsive disorder (OCD), Original Investigation, Aged, 80 and over, Cerebral Cortex, 0303 health sciences, pathology [Depressive Disorder, Major], Principal Component Analysis, Adolescent psychiatry, 10058 Department of Child and Adolescent Psychiatry, Middle Aged, diagnostic imaging [Obsessive-Compulsive Disorder], REGIONS, Magnetic Resonance Imaging, 3. Good health, FALSE DISCOVERY RATE, Psychiatry and Mental health, Autism spectrum disorder, Schizophrenia, growth & development [Cerebral Cortex], Child, Preschool, Major depressive disorder, diagnostic imaging [Schizophrenia], Esquizofrènia, Female, Psiquiatria infantil, Psiquiatria de l'adolescència, diagnostic imaging [Autism Spectrum Disorder], Adult, medicine.medical_specialty, Adolescent, Human Development, 610 Medicine & health, diagnostic imaging [Bipolar Disorder], pathology [Autism Spectrum Disorder], diagnostic imaging [Depressive Disorder, Major], 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Neuroimaging, SDG 3 - Good Health and Well-being, CEREBRAL-CORTEX, Child psychiatry, medicine, Attention deficit hyperactivity disorder, Humans, Bipolar disorder, ddc:610, Psychiatry, pathology [Schizophrenia], 030304 developmental biology, Aged, Depressive Disorder, Major, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, DENDRITE, Computational Biology, Correction, pathology [Attention Deficit Disorder with Hyperactivity], physiology [Fetal Development], medicine.disease, PATHOLOGY, pathology [Bipolar Disorder], pathology [Obsessive-Compulsive Disorder], 10036 Medical Clinic, Attention Deficit Disorder with Hyperactivity, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Case-Control Studies, DENSITY, ORIGINS, HIPPOCAMPUS, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], pathology [Cerebral Cortex], Autisme, business, Neuroscience, 030217 neurology & neurosurgery, physiology [Human Development]
Abstract

[Importance] Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood., [Objective] To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia., [Design, Setting, and Participants] Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244., [Main Outcomes and Measures] Interregional profiles of group difference in cortical thickness between cases and controls., [Results] A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders., [Conclusions and Relevance] In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.

Published
2021
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38. Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

Author

Campos, Adrian I, Thompson, Paul M., Veltman, Dick J, Pozzi, Elena, van Veltzen, Laura S, Jahanshad, Neda, Adams, Mark J, Baune, Bernhard T, Berger, Klaus, Brosch, Katharina, Bülow, Robin, Connolly, Colm G, Dannlowski, Udo, Davey, Christopher G, de Zubicaray, Greig I, Dima, Danai, Erwin-Grabner, Tracy, Evans, Jennifer W, Fu, Cynthia H Y, Gotlib, Ian H, Goya-Maldonado, Roberto, Grabe, Hans J, Grotegerd, Dominik, Harris, Matthew A, Harrison, Ben J, Hatton, Sean N, Hermesdorf, Marco, Hickie, Ian B, Ho, Tiffany C, Kircher, Tilo, Krug, Axel, Lagopoulos, Jim, Lemke, Hannah, McMahon, Katie, MacMaster, Frank P, Martin, Nicholas G, McIntosh, Andrew M, Medland, Sarah E, Meinert, Susanne, Meller, Tina, Nenadic, Igor, Opel, Nils, Redlich, Ronny, Reneman, Liesbeth, Repple, Jonathan, Sacchet, Matthew D, Schmitt, Simon, Schrantee, Anouk, Sim, Kang, Singh, Aditya, Stein, Frederike, Strike, Lachlan T, van der Wee, Nic J A, van der Werff, Steven J A, Völzke, Henry, Waltemate, Lena, Whalley, Heather C, Wittfeld, Katharina, Wright, Margaret J., Yang, Tony T, Zarate, Carlos A, Schmaal, Lianne, Rentería, Miguel E, other, and, Campos, Adrian I, Thompson, Paul M., Veltman, Dick J, Pozzi, Elena, van Veltzen, Laura S, Jahanshad, Neda, Adams, Mark J, Baune, Bernhard T, Berger, Klaus, Brosch, Katharina, Bülow, Robin, Connolly, Colm G, Dannlowski, Udo, Davey, Christopher G, de Zubicaray, Greig I, Dima, Danai, Erwin-Grabner, Tracy, Evans, Jennifer W, Fu, Cynthia H Y, Gotlib, Ian H, Goya-Maldonado, Roberto, Grabe, Hans J, Grotegerd, Dominik, Harris, Matthew A, Harrison, Ben J, Hatton, Sean N, Hermesdorf, Marco, Hickie, Ian B, Ho, Tiffany C, Kircher, Tilo, Krug, Axel, Lagopoulos, Jim, Lemke, Hannah, McMahon, Katie, MacMaster, Frank P, Martin, Nicholas G, McIntosh, Andrew M, Medland, Sarah E, Meinert, Susanne, Meller, Tina, Nenadic, Igor, Opel, Nils, Redlich, Ronny, Reneman, Liesbeth, Repple, Jonathan, Sacchet, Matthew D, Schmitt, Simon, Schrantee, Anouk, Sim, Kang, Singh, Aditya, Stein, Frederike, Strike, Lachlan T, van der Wee, Nic J A, van der Werff, Steven J A, Völzke, Henry, Waltemate, Lena, Whalley, Heather C, Wittfeld, Katharina, Wright, Margaret J., Yang, Tony T, Zarate, Carlos A, Schmaal, Lianne, Rentería, Miguel E, and other, and

Abstract

Background: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. Methods: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects. Results: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe. Conclusions: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.

Published
2021

39. Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Author

Hansen, Niels, Singh, Aditya, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dobisch, Laura, Dechent, Peter, Ertl-Wagner, Birgit B., Fliessbach, Klaus, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Priller, Josef, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Tscheuschler, Maike, Vukovich, Ruth, Wiltfang, Jens, Duezel, Emrah, Jessen, Frank, Goya-Maldonado, Roberto, Hansen, Niels, Singh, Aditya, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dobisch, Laura, Dechent, Peter, Ertl-Wagner, Birgit B., Fliessbach, Klaus, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Priller, Josef, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Tscheuschler, Maike, Vukovich, Ruth, Wiltfang, Jens, Duezel, Emrah, Jessen, Frank, and Goya-Maldonado, Roberto

Abstract

Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.

Published
2021

40. Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Author

Hansen, Niels, primary, Singh, Aditya, additional, Bartels, Claudia, additional, Brosseron, Frederic, additional, Buerger, Katharina, additional, Cetindag, Arda C., additional, Dobisch, Laura, additional, Dechent, Peter, additional, Ertl-Wagner, Birgit B., additional, Fliessbach, Klaus, additional, Haynes, John D., additional, Heneka, Michael T., additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Laske, Christoph, additional, Metzger, Coraline D., additional, Munk, Matthias H., additional, Peters, Oliver, additional, Priller, Josef, additional, Roy, Nina, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Spottke, Annika, additional, Spruth, Eike J., additional, Teipel, Stefan, additional, Tscheuschler, Maike, additional, Vukovich, Ruth, additional, Wiltfang, Jens, additional, Duezel, Emrah, additional, Jessen, Frank, additional, and Goya-Maldonado, Roberto, additional

Published
2021
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44. Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI

Author

Komorowski, Arkadiusz, primary, Vidal, Ramon, additional, Singh, Aditya, additional, Murgaš, Matej, additional, Pena-Centeno, Tonatiuh, additional, Gryglewski, Gregor, additional, Kasper, Siegfried, additional, Wiltfang, Jens, additional, Lanzenberger, Rupert, additional, and Goya-Maldonado, Roberto, additional

Published
2020
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45. Hippocampal Subfields in Alzheimer's Disease Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline, Unipolar and Bipolar Depression

Author

Hansen, Niels, primary, Singh, Aditya, additional, Vogelgsang, Jonathan, additional, Fischer, Andre, additional, Schneider, Anja, additional, Spottke, Annika, additional, Laske, Christoph, additional, Jessen, Frank, additional, Priller, Joseph, additional, Buerger, Katharina, additional, Peters, Oliver, additional, Teipel, Stefan, additional, Duezel, Emrah, additional, Wiltfang, Jens, additional, and Goya-Maldonado, Roberto, additional

Published
2020
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46. Hippocampal Subfields in Alzheimer's Disease Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline, Unipolar and Bipolar Depression

Author

Hansen, Niels, Singh, Aditya, Vogelgsang, Jonathan, Fischer, Andre, Schneider, Anja, Spottke, Annika, Laske, Christoph, Jessen, Frank, Priller, Joseph, Buerger, Katharina, Peters, Oliver, Teipel, Stefan, Duezel, Emrah, Wiltfang, Jens, Goya-Maldonado, Roberto, Hansen, Niels, Singh, Aditya, Vogelgsang, Jonathan, Fischer, Andre, Schneider, Anja, Spottke, Annika, Laske, Christoph, Jessen, Frank, Priller, Joseph, Buerger, Katharina, Peters, Oliver, Teipel, Stefan, Duezel, Emrah, Wiltfang, Jens, and Goya-Maldonado, Roberto

Published
2020

47. No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

Author

de Kovel, Carolien G.F., primary, Aftanas, Lyubomir, additional, Aleman, André, additional, Alexander-Bloch, Aaron F., additional, Baune, Bernhard T., additional, Brack, Ivan, additional, Bülow, Robin, additional, Busatto Filho, Geraldo, additional, Carballedo, Angela, additional, Connolly, Colm G., additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Davey, Christopher G., additional, Dima, Danai, additional, Dohm, Katharina, additional, Erwin-Grabner, Tracy, additional, Frodl, Thomas, additional, Fu, Cynthia H.Y., additional, Hall, Geoffrey B., additional, Glahn, David C., additional, Godlewska, Beata, additional, Gotlib, Ian H., additional, Goya-Maldonado, Roberto, additional, Grabe, Hans Jörgen, additional, Groenewold, Nynke A., additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Harris, Mathew A., additional, Harrison, Ben J., additional, Hatton, Sean N., additional, Hickie, Ian B., additional, Ho, Tiffany C., additional, Jahanshad, Neda, additional, Kircher, Tilo, additional, Krämer, Bernd, additional, Krug, Axel, additional, Lagopoulos, Jim, additional, Leehr, Elisabeth J., additional, Li, Meng, additional, MacMaster, Frank P., additional, MacQueen, Glenda, additional, McIntosh, Andrew M., additional, McLellan, Quinn, additional, Medland, Sarah E., additional, Mueller, Bryon A., additional, Nenadic, Igor, additional, Osipov, Evgeny, additional, Papmeyer, Martina, additional, Portella, Maria J., additional, Reneman, Liesbeth, additional, Rosa, Pedro G.P., additional, Sacchet, Matthew D., additional, Schnell, Knut, additional, Schrantee, Anouk, additional, Sim, Kang, additional, Simulionyte, Egle, additional, Sindermann, Lisa, additional, Singh, Aditya, additional, Stein, Dan J., additional, Ubani, Benjamin N., additional, Van der Wee, Nic J.A., additional, Van der Werff, Steven J.A., additional, Veer, Ilya M., additional, Vives-Gilabert, Yolanda, additional, Völzke, Henry, additional, Walter, Henrik, additional, Walter, Martin, additional, Schreiner, Melinda Westlund, additional, Whalley, Heather, additional, Winter, Nils, additional, Wittfeld, Katharina, additional, Yang, Tony T., additional, Yüksel, Dilara, additional, Zaremba, Dario, additional, Thompson, Paul M., additional, Veltman, Dick J., additional, Schmaal, Lianne, additional, and Francks, Clyde, additional

Published
2019
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48. ENIGMA MDD: Seven Years of Global Neuroimaging Studies of Major Depression through Worldwide Data Sharing

Author

Schmaal, Lianne, primary, Pozzi, Elena, additional, Ho, Tiffany, additional, van Velzen, Laura S., additional, Veer, Ilya, additional, Opel, Nils, additional, Van Someren, Eus, additional, Han, Laura K. M., additional, Aftanas, Lybomir, additional, Aleman, Andre, additional, Baune, Bernhard T., additional, Berger, Klaus, additional, Blanken, Tessa, additional, Capitao, Liliana, additional, Couvy-Duchesne, Baptiste, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Davey, Christopher, additional, Erwin-Grabner, Tracy, additional, Evans, Jennifer, additional, Frodl, Thomas, additional, Fu, Cynthia H.Y., additional, Godlewska, Beata, additional, Gotlib, Ian, additional, Goya-Maldonado, Roberto, additional, Grabe, Hans J., additional, Groenewold, Nynke A., additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Gutman, Boris A., additional, Hall, Geoffrey, additional, Harrison, Ben, additional, Hatton, Sean N, additional, Hermesdorf, Marco, additional, Hickie, Ian, additional, Hilland, Eva, additional, Irungu, Benson, additional, Jonassen, Rune, additional, Kelly, Sinead, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, Krug, Axel, additional, Landrø, Nils Inge, additional, Lagopoulos, Jim, additional, Leerssen, Jeanne, additional, Li, Meng, additional, Linden, David, additional, MacMaster, Frank, additional, Mcintosh, Andrew, additional, Mehler, David Marc Anton, additional, Nenadic, Igor, additional, Penninx, Brenda, additional, Portella, Maria, additional, Reneman, Liesbeth, additional, Rentería, Miguel E., additional, Sacchet, Matthew, additional, Sämann, Philipp Gero, additional, Schrantee, Anouk, additional, Sim, Kang, additional, Soares, Jair, additional, Stein, Dan J., additional, Tozzi, Leonardo, additional, van der Wee, Nic, additional, van Tol, Marie-José, additional, Vermeiren, Robert, additional, Vives-Gilabert, Yolanda, additional, Walter, Henrik, additional, Walter, Martin, additional, Whalley, Heather C, additional, Wittfeld, Katharina, additional, Whittle, Sarah, additional, Wright, Margaret J., additional, Yang, Tony, additional, Zarate, Carlos A., additional, Thomopoulos, Sophia I, additional, Jahanshad, Neda, additional, Thompson, Paul, additional, and Veltman, Dick, additional

Published
2019
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