28 results on '"Gozke E"'
Search Results
2. A database for screening and registering late onset Pompe disease in Turkey
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Gokyigit, M.C., Ekmekci, H., Durmus, H., Karlı, N., Koseoglu, E., Aysal, F., Kotan, D., Ali, A., Koytak, P.K., Karasoy, H., Yaman, A., Sengun, İ.S., Sayin, R., Tiftikcioglu, B.I., Soysal, A., Tutkavul, K., Bayrak, A.O., Kısabay, A., Elci, M.A., Yayla, V., Yılmaz, İ.A., Ozdamar, S.E., Erdoğan, Çağdaş, Tasdemir, N., Serdaroglu Oflazer, P., Deymeer, F., Parman, Y., Kendirci, M., Sayan, S., Celebi, L.G., Uluç, K., Tanrıdağ, T., Yuceyar, N., Ekmekci, O., Colakoglu, B.D., Ozturk, S., Tireli, H., Selcuki, D., Neyal, A.M., Kayran, Y., Aluclu, M.U., Koyuncuoglu, H.R., Tokucoglu, F., Secil, Y., Guney, F., Gozke, E., Balaban, H., Akalın, M.A., Koc, A.F., Mulayim, S., Turgut, N., Turkish Study Group for Late Onset Pompe Disease, Gokyigit, Munevver Celik Sisli Hamidiye Etfal Ed Res Hosp, Dept Neurol, Istanbul, Turkey, Ekmekci, Hakan Selcuk Univ Hosp, Dept Neurol, Konya, Turkey, Durmus, Hacer, Oflazer, Piraye Serdaroglu Istanbul Univ, Istanbul Fac Med, Dept Neurol Istanbul, Istanbul, Turkey, Karll, Necdet Uludag Univ Hosp, Dept Neurol, Bursa, Turkey, Koseoglu, Emel Erciyes Univ Hosp, Dept Neurol, Kayseri, Turkey, Aysal, Fikret Medipol Univ Hosp, Istanbul, Turkey, Kotan, Dilcan Sakarya Univ Hosp, Dept Neurol, Sakarya, Turkey, Ali, Asuman Sevket Yilnzaz Res Hosp, Dept Neurol, Bursa, Turkey, Koytak, Pinar Kahraman Marmara Univ Hosp, Dept Neurol, Istanbul, Turkey, Karasoy, Hatice Ege Univ Hosp, Dept Neurol, Izmir, Turkey, Yaman, Aylin Antalya Ed Res Hosp, Dept Neurol, Antalya, Turkey, Sengun, Ihsan Sukru Dokuz Eylul Univ Hosp, Dept Neurol, Izmir, Turkey, Sayin, Refah Yuzuncu Yil Univ Hosp, Dept Neurol, Van, Turkey, Tiftikcioglu, Bedile Irem Tepecik Ed Res Hosp, Izmir, Turkey, Soysal, Aysun Balarkoy Psychiat & Neurol Hosp, Dept Neurol, Istanbul, Turkey, Tutkavul, Kemal Haydarpa Ed Res Hosp, Dept Neurol, Istanbul, Turkey, Bayrak, Ayse Oytun Ondokuz Maps Univ Hosp, Dept Neurol, Samsun, Turkey, Kisabay, Aysin Celal Bayar Univ Hosp, Dept Neurol Manisa, Manisa, Turkey, Elci, Mehmet Ali Gaziantep Univ Hosp, Dept Neurol Gaziantep, Gaziantep, Turkey, Yayla, Vildan Balarkoy Sadi Konuk Ed Res Hosp, Dept Neurol, Istanbul, Turkey, Yilmaz, Ibrahim Arda Mersin Univ Hosp, Dept Neurol, Mersin, Turkey, Ozdamar, Sevim Erdem Hacettepe Univ Hosp, Dept Neurol, Ankara, Turkey, Erdogan, Cagdas Pamukkale Univ Hosp, Dept Neurol, Denizli, Turkey, Tasdemir, Nebahat Dicle Univ Hosp, Dept Neurol, Diyarbakir, Turkey, Gokyigit, Munevver Celik Beykent Univ, Istanbul, Turkey, Gokyigit, Munevver Celik -- 0000-0002-3395-3460, Uluc, Kayihan -- 0000-0001-6132-2300, Piraye -- 0000-0001-8202-5313, Ekmekci, Hakan -- 0000-0002-5605-2980, Dept. of Neurology, Sisli Hamidiye Etfal Ed. Res. Hosp., Istanbul, Turkey, Dept. of Neurology, Selçuk University Hosp., Konya, Turkey, Dept. of Neurology Istanbul, İstanbul Medical Faculty, University of Istanbul, Istanbul, Turkey, Dept. of Neurology, Uludağ University Hosp., Bursa, Turkey, Dept. of Neurology, Erciyes University Hosp., Kayseri, Turkey, Medipol University Hosp., Istanbul, Turkey, Dept. of Neurology, Sakarya University Hosp., Sakarya, Turkey, Dept. of Neurology, Sevket Yılmaz Ed. Res. Hosp., Bursa, Turkey, Dept. of Neurology, Marmara University Hospital, Istanbul, Turkey, Dept. of Neurology, Ege University Hosp., İzmir, Turkey, Dept. of Neurology, Antalya Ed. Res. Hosp., Antalya, Turkey, Dept. of Neurology, Dokuz Eylül University Hosp., İzmir, Turkey, Dept. of Neurology, Yüzüncü Yil University Hospital, Van, Turkey, Tepecik Ed. Res. Hosp., Izmir, Turkey, Dept. of Neurology, Bakırkoy Psychiatric and Neurological Hosp., Istanbul, Turkey, Dept. of Neurology, Haydarpaşa Ed. Res. Hosp., İstanbul, Turkey, Dept. of Neurology, Ondokuz Mayıs University Hosp., Samsun, Turkey, Dept. of Neurology Manisa, Celal Bayar University Hosp., Manisa, Turkey, Dept. of Neurology Gaziantep, Gaziantep University Hosp., Gaziantep, Turkey, Dept. of Neurology, Bakırkoy Sadi Konuk Ed. Res. Hosp., Istanbul, Turkey, Dept. of Neurology, Mersin University Hosp., Mersin, Turkey, Dept. of Neurology, Hacettepe University Hosp., Ankara, Turkey, Dept. of Neurology, Pamukkale University Hosp., Denizli, Turkey, Dept. of Neurology, Dicle University Hosp., Diyarbakır, Turkey, Istanbul Medical Faculty, Dept. of Neurology, University of Istanbul, Istanbul, Turkey, Dept. of Neurology, Ege University Hosp., Izmir, Turkey, Dept. of Neurology, Dokuz Eylul University Hosp., Izmir, Turkey, Dept. of Neurology, Selcuk University Hospital, Konya, Turkey, Dept. of Neurology, Haydarpasa Ed. Res. Hosp., Istanbul, Turkey, Dept. of Neurology, Celal Bayar University Hosp., Manisa, Turkey, Dept. of Neurology, Gaziantep University Hosp., Gaziantep, Turkey, Dept. of Neurology, Bakirkoy, Sadi Konuk Ed. Res. Hosp., Istanbul, Turkey, Dept. of Neurology, Dicle University Hosp., Diyarbakir, Turkey, Dept. of Neurology, Suleyman Demirel University Hosp., Isparta, Turkey, Dept. of Neurology, Tepecik Ed. Res. Hosp., Izmir, Turkey, Dept of Neurology, Atatürk Ed. Res. Hosp., Izmir, Turkey, Meram Medical Faculty, Dept. of Neurology, Necmettin Erbakan University, Konya, Turkey, Dept. of Neurology, Fatih Sultan Mehmet Ed. Res. Hosp., Istanbul, Turkey, Dept. of Neurology, Cumhuriyet University Hosp., Sivas, Turkey, Cerrahpasa Medical Faculty, Dept. of Neurology, Istanbul University, Istanbul, Turkey, Dept. of Neurology, Cukurova University Hosp., Adana, Turkey, Dept. of Neurology, Kocaeli University Hosp., Izmit, Turkey, Dept. of Neurology, Namık Kemal University Hosp., Tekirdag, Turkey, Beykent University, Turkey, Çukurova Üniversitesi, Ondokuz Mayıs Üniversitesi, Gokyigit, M.C., Dept. of Neurology, Sisli Hamidiye Etfal Ed. Res. Hosp., Istanbul, Turkey, Beykent University, Turkey -- Ekmekci, H., Dept. of Neurology, Selçuk University Hosp., Konya, Turkey -- Durmus, H., Dept. of Neurology Istanbul, İstanbul Medical Faculty, University of Istanbul, Istanbul, Turkey -- Karlı, N., Dept. of Neurology, Uludağ University Hosp., Bursa, Turkey -- Koseoglu, E., Dept. of Neurology, Erciyes University Hosp., Kayseri, Turkey -- Aysal, F., Medipol University Hosp., Istanbul, Turkey -- Kotan, D., Dept. of Neurology, Sakarya University Hosp., Sakarya, Turkey -- Ali, A., Dept. of Neurology, Sevket Yılmaz Ed. Res. Hosp., Bursa, Turkey -- Koytak, P.K., Dept. of Neurology, Marmara University Hospital, Istanbul, Turkey -- Karasoy, H., Dept. of Neurology, Ege University Hosp., İzmir, Turkey -- Yaman, A., Dept. of Neurology, Antalya Ed. Res. Hosp., Antalya, Turkey -- Sengun, İ.S., Dept. of Neurology, Dokuz Eylül University Hosp., İzmir, Turkey -- Sayin, R., Dept. of Neurology, Yüzüncü Yil University Hospital, Van, Turkey -- Tiftikcioglu, B.I., Tepecik Ed. Res. Hosp., Izmir, Turkey -- Soysal, A., Dept. of Neurology, Bakırkoy Psychiatric and Neurological Hosp., Istanbul, Turkey -- Tutkavul, K., Dept. of Neurology, Haydarpaşa Ed. Res. Hosp., İstanbul, Turkey -- Bayrak, A.O., Dept. of Neurology, Ondokuz Mayıs University Hosp., Samsun, Turkey -- Kısabay, A., Dept. of Neurology Manisa, Celal Bayar University Hosp., Manisa, Turkey -- Elci, M.A., Dept. of Neurology Gaziantep, Gaziantep University Hosp., Gaziantep, Turkey -- Yayla, V., Dept. of Neurology, Bakırkoy Sadi Konuk Ed. Res. Hosp., Istanbul, Turkey -- Yılmaz, İ.A., Dept. of Neurology, Mersin University Hosp., Mersin, Turkey -- Ozdamar, S.E., Dept. of Neurology, Hacettepe University Hosp., Ankara, Turkey -- Erdogan, C., Dept. of Neurology, Pamukkale University Hosp., Denizli, Turkey -- Tasdemir, N., Dept. of Neurology, Dicle University Hosp., Diyarbakır, Turkey -- Serdaroglu Oflazer, P., Dept. of Neurology Istanbul, İstanbul Medical Faculty, University of Istanbul, Istanbul, Turkey -- Deymeer, F., Istanbul Medical Faculty, Dept. of Neurology, University of Istanbul, Istanbul, Turkey -- Parman, Y., Istanbul Medical Faculty, Dept. of Neurology, University of Istanbul, Istanbul, Turkey -- Kendirci, M., Dept. of Neurology, Erciyes University Hosp., Kayseri, Turkey -- Sayan, S., Dept. of Neurology, Sakarya University Hosp., Sakarya, Turkey -- Celebi, L.G., Dept. of Neurology, Sisli Hamidiye Etfal Ed. Res. Hosp., Istanbul, Turkey -- Uluç, K., Dept. of Neurology, Marmara University Hospital, Istanbul, Turkey -- Tanrıdağ, T., Dept. of Neurology, Marmara University Hospital, Istanbul, Turkey -- Yuceyar, N., Dept. of Neurology, Ege University Hosp., Izmir, Turkey -- Ekmekci, O., Dept. of Neurology, Ege University Hosp., Izmir, Turkey -- Colakoglu, B.D., Dept. of Neurology, Dokuz Eylul University Hosp., Izmir, Turkey -- Ozturk, S., Dept. of Neurology, Selcuk University Hospital, Konya, Turkey -- Tireli, H., Dept. of Neurology, Haydarpasa Ed. Res. Hosp., Istanbul, Turkey -- Selcuki, D., Dept. of Neurology, Celal Bayar University Hosp., Manisa, Turkey -- Neyal, A.M., Dept. of Neurology, Gaziantep University Hosp., Gaziantep, Turkey -- Kayran, Y., Dept. of Neurology, Bakirkoy, Sadi Konuk Ed. Res. Hosp., Istanbul, Turkey -- Aluclu, M.U., Dept. of Neurology, Dicle University Hosp., Diyarbakir, Turkey -- Koyuncuoglu, H.R., Dept. of Neurology, Suleyman Demirel University Hosp., Isparta, Turkey -- Tokucoglu, F., Dept. of Neurology, Tepecik Ed. Res. Hosp., Izmir, Turkey -- Secil, Y., Dept of Neurology, Atatürk Ed. Res. Hosp., Izmir, Turkey -- Guney, F., Meram Medical Faculty, Dept. of Neurology, Necmettin Erbakan University, Konya, Turkey -- Gozke, E., Dept. of Neurology, Fatih Sultan Mehmet Ed. Res. Hosp., Istanbul, Turkey -- Balaban, H., Dept. of Neurology, Cumhuriyet University Hosp., Sivas, Turkey -- Akalın, M.A., Cerrahpasa Medical Faculty, Dept. of Neurology, Istanbul University, Istanbul, Turkey -- Koc, A.F., Dept. of Neurology, Cukurova University Hosp., Adana, Turkey -- Mulayim, S., Dept. of Neurology, Kocaeli University Hosp., Izmit, Turkey -- Turgut, N., Dept. of Neurology, Namık Kemal University Hosp., Tekirdag, Turkey -- Turkish Study Group for Late Onset Pompe Disease, Gokyigit, MC, Ekmekci, H, Durmus, H, Karll, N, Koseoglu, E, Aysal, F, Kotan, D, Ali, A, Koytak, PK, Karasoy, H, Yaman, A, Sengun, IS, Sayin, R, Tiftikcioglu, BI, Soysal, A, Tutkavul, K, Bayrak, AO, Kisabay, A, Elci, MA, Yayla, V, Yilmaz, IA, Ozdamar, SE, Erdogan, C, Tasdemir, N, Oflazer, PS, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, and Kotan Dündar, Dilcan
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0301 basic medicine ,glycogen storage disease type 2 ,Pediatrics ,enzyme assay ,Databases, Factual ,Turkey ,Turkey (republic) ,0302 clinical medicine ,data base ,Glycogen storage disease type II ,Prevalence ,Mass Screening ,creatine kinase blood level ,Registries ,Age of Onset ,Genetics (clinical) ,medicine.diagnostic_test ,Glycogen Storage Disease Type II ,adult ,genetic screening ,Creatine Kinase/blood ,Glycogen Storage Disease Type II/blood/diagnosis/*epidemiology ,Humans ,Turkey/epidemiology ,Dried blood spot ,aged ,female ,Neurology ,priority journal ,LOPD ,Acid alpha-glucosidase ,histopathology ,disease registry ,medicine.symptom ,myopathy ,mutational analysis ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Registry ,electrodiagnosis ,Late onset ,Article ,enzyme blood level ,03 medical and health sciences ,male ,respiratory distress ,medicine ,controlled study ,human ,Myopathy ,Acid alpha glucosidase ,Mass screening ,Genetic testing ,muscle weakness ,business.industry ,creatine kinase ,screening ,glucan 1,4 alpha glucosidase ,medicine.disease ,major clinical study ,human tissue ,late onset disorder ,Limb girdle muscle weakness ,030104 developmental biology ,multicenter study ,Pediatrics, Perinatology and Child Health ,Neurosciences & Neurology ,Neurology (clinical) ,Age of onset ,business ,030217 neurology & neurosurgery - Abstract
WOS: 000430763800010 PubMed ID: 29395671 The aim of this study was to search for the frequency of late onset Pompe disease (LOPD) among patients who had a myopathy with unknown diagnosis registered in the pre-diagnostic part of a novel registry for LOPD within a collaborative study of neurologists working throughout Turkey. Included in the study were 350 patients older than 18 years who have a myopathic syndrome without a proven diagnosis by serum creatine kinase (CK) levels, electrodiagnostic studies, and/or muscle pathology, and/or genetic tests for myopathies other than LOPD. Acid alpha glucosidase (GAA) in dried blood spot was measured in each patient at two different university laboratories. LOPD was confirmed by mutation analysis in patients with decreased GAA levels from either both or one of the laboratories. Pre-diagnostic data, recorded by 45 investigators from 32 centers on 350 patients revealed low GAA levels in a total of 21 patients; from both laboratories in 6 and from either one of the laboratories in 15. Among them, genetic testing proved LOPD in 3 of 6 patients and 1 of 15 patients with decreased GAA levels from both or one of the laboratories respectively. Registry was transferred to Turkish Neurological Association after completion of the study for possible future use and development. Our collaborative study enabled collection of a considerable amount of data on the registry in a short time. GAA levels by dried blood spot even from two different laboratories in the same patient may not prove LOPD. LOPD seemed to be rarer in Turkey than in Europe. (C) 2017 Elsevier B.V. All rights reserved.
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- 2018
3. Ulnar nerve entrapment at wrist associated with carpal tunnel syndrome
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Gozke, E, Dortcan, N, Kocer, A, Cetinkaya, M, Akyuz, G, and Us, O
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- 2003
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4. ID 21 – Riche–Cannieu anastomosis: A case report
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Gozke, E., primary, Gurer, R., additional, Gurbuzer, N., additional, and Dortcan, N., additional
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- 2016
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5. Gamma-glutamyl transferase levels and cerebrovascular risk factors in patients with acute ischemic stroke
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Gurbuzer, N., primary, Gozke, E., additional, and Basturk, Z. Ayhan, additional
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- 2013
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6. Nerve conduction studies in chronic venous insufficiency of lower extremities
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Gozke, E, primary, Celebi, D, additional, Biber, S, additional, Baltacioglu, T, additional, and Cetinkaya, M, additional
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- 2005
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7. Hemogram and inflammatory indices in pain-free periods in migraine patients without aura.
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Kömürcü HF, Erkalaycı C, and Gozke E
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- Humans, Female, Male, Adult, Retrospective Studies, Middle Aged, Blood Cell Count, Young Adult, Erythrocyte Indices, Inflammation blood, Migraine without Aura blood, Migraine without Aura physiopathology
- Abstract
Objectives: Since neurogenic inflammation and hemoconcentration have a prominent role in the pathophysiology of migraine, evaluation of hemogram parameters and indices showing inflammation can yield important information. In this study, we have investigated blood cell counts and ratios, systemic inflammation index (SII), systemic inflammation response index (SIRI) and red cell index (RCI) in the painless periods between pain attacks in patients with episodic migraine without aura., Methods: Hemogram data of both 309 patients diagnosed with migraine without aura related to pain-free periods and 199 healthy individuals were retrospectively retrieved from hospital records. Data related to erythrocyte, leukocyte, lymphocyte, platelet, monocyte, eosinophil counts; hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio (MLR), and neutrophil/monocyte ratio, SII, SIRI and RCI values were scanned to reveal intergroup differences in terms of these parameters., Results: A comparison of laboratory parameters revealed that certain indices differed significantly between the migraine and control groups. MLR ( p = 0.005) and RDW ( p < 0.001) values were significantly lower, while platelet ( p = 0.016), MPV ( p < 0.001) and hematocrit ( p = 0.014) were significantly higher in the migraine patient group compared to the control group. There was no significant difference between the two groups regarding other parameters., Discussion: Higher hematocrit, platelet, mean platelet volume and lower monocyte/lymphocyte ratio values in this study support that hemoconcentration and chronic inflammation persist even in the absence of pain attacks in migraine patients without aura.
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- 2025
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8. Cytokines and Other Laboratory Parameters of Hospitalized COVID-19 Patients that Predict Intensive Care Unit Admission.
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Cakir N, Gozke E, Ekinci SC, Isik SA, Osken S, Kaya Z, Guner EA, Ak F, Yazicilar HA, Kilic H, Anil BS, and Ozgul M
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Adult, SARS-CoV-2, Biomarkers blood, Hospitalization, COVID-19 blood, COVID-19 diagnosis, COVID-19 epidemiology, COVID-19 immunology, COVID-19 therapy, Intensive Care Units statistics & numerical data, Cytokines blood
- Abstract
Background: This study aimed to investigate the roles of cytokines and other laboratory parameters in determining the need for intensive care in COVID-19 patients., Methods: This is a retrospective observational study. Demographic, clinical, and laboratory parameters of the patients were evaluated. Thirteen cytokines were measured along with baseline laboratory tests at admission and at 48-hour intervals: IL-1β, IFN-α, IFN-β, TNF-α, MCP-1, IL-6, IL -8, IL-10, IL-2p70, IL-17A, IL-18, IL-23, and IL-33., Results: COVID-19 was confirmed by PCR in 116 hospitalized patients. The mean age was 55.3 ± 16.4 years. Seventy-four (63.8%) of the patients were male and 42 (36.2%) were female. Twenty-two (18.9%) patients (16 male, 6 female) were transferred to the intensive care unit. A significant increase in white blood cell (WBC), neutrophil (Neu) and lymphocyte (Lym) counts, Neu/Lym ratio (NLR), lactate dehydrogenase (LDH), INR (international normalized ratio), activated prothrombin time (aPTT), D-dimer (D-D), troponin (Trop), Pro-BNP (BNP), procalcitonin (PCT), ferritin (Fer), and alanine aminotransferase (ALT) values were observed in those requiring intensive care. A significant decrease was found in albumin (Alb) levels and Lym counts. Alb levels appeared to be protective against admission to intensive care. Except for IFN- α, IL-23, and IL-33, the baseline values of other cytokines were above the threshold values. MCP-1 and IL-6 were higher in patients requiring intensive care., Conclusions: High NLR and LDH and low Alb levels, especially with an increase in MCP-1 and IL-6, were found to be the best predictors of a serious COVID-19 infection.
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- 2024
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9. Evaluation of Peripapillary Choroidal Thickness, Retinal Nerve Fiber Layer, and Optic Nerve Head Parameters in Patients with Multiple Sclerosis.
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Garli M, Kurna SA, Gozke E, and Yukselen NP
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Objectives: The objectives of the study are to assess the peripapillary choroidal thickness (PPCT), retinal nerve fiber layer (RNFL), and optic nerve head (ONH) parameters in multiple sclerosis (MS) patients compared to healthy subjects., Methods: One hundred and twenty-eight eyes from 64 patients were included in this cross-sectional study. Eighty-two eyes of 41 MS patients and 46 eyes of 23 healthy subjects were examined. PPCT and RNFL were measured using spectral-domain optical coherence tomography (OCT). PPCT was measured from the four quadrants around the optic disc at a distance of 1 mm (PPCT-1) and 2 mm (PPCT-2) from the edge of the ONH and the beginning of the retinal pigment epithelium. ONH parameters were measured with Heidelberg retinal tomography (HRT-3). Disease duration, the number of episodes, MS subtypes, and Expanded Disability Status Scale (EDSS) scores were recorded., Results: The RNFL measurements and the mean PPCT-1 and PPCT-2 were significantly lower in MS patients compared to healthy individuals. PPCT-1 and PPCT-2 were measured as the thickest in the temporal quadrant, followed by the superior, nasal, and inferior quadrants, respectively, in both groups. When the ONH parameters were evaluated, cup/disc area ratio, cup area, and cup volume values were significantly higher, whereas optic rim volume and rim area values were significantly lower in MS patients compared to healthy subjects (p<0.05). We observed significant changes in RNFL and ONH parameters of MS patients in parallel with disease severity determined by EDSS scores and the presence of optic neuritis., Conclusion: There were significant changes in RNFL thickness, PPCT, and ONH parameters when MS patients were compared with healthy subjects. Assessment of RNFL and PPCT with OCT and ONH with HRT-3 may be useful in the follow-up of MS patients., Competing Interests: Conflict of Interest: None declared.
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- 2024
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10. Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study.
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Tasdemir V, Sirin NG, Cakar A, Culha A, Soysal A, Elmali AD, Gunduz A, Arslan B, Yalcin D, Atakli D, Orhan EK, Sanli E, Tuzun E, Gozke E, Gursoy E, Savrun FK, Uslu FI, Aysal F, Durmus H, Bulbul H, Ertas FI, Uluc K, Tutkavul K, Baysal L, Baslo MB, Kiziltan M, Mercan M, Pazarci N, Uzun N, Akan O, Cokar O, Koytak PK, Sürmeli R, Gunaydin S, Ayas S, Baslo SA, Yayla V, Yilmaz V, Parman Y, Matur Z, Acar ZU, and Oge AE
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- Humans, Prospective Studies, Neural Conduction physiology, Electrodiagnosis methods, Gangliosides, Antibodies, Guillain-Barre Syndrome
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Background and Aims: This study aimed to identify the clinical characteristics and electrodiagnostic subtypes of Guillain-Barré syndrome (GBS) in Istanbul., Methods: Patients with GBS were prospectively recruited between April 2019 and March 2022 and two electrodiagnostic examinations were performed on each patient. The criteria of Ho et al., Hadden et al., Rajabally et al., and Uncini et al. were compared for the differentiation of demyelinating and axonal subtypes, and their relations with anti-ganglioside antibodies were analyzed., Results: One hundred seventy-seven patients were included, 69 before the coronavirus disease 2019 pandemic (April 2019-February 2020) and 108 during the pandemic (March 2020-March 2022), without substantial changes in monthly frequencies. As compared with the criteria of Uncini et al., demyelinating GBS subtype diagnosis was more frequent according to the Ho et al. and Hadden et al. criteria (95/162, 58.6% vs. 110/174, 63.2% and 121/174, 69.5%, respectively), and less frequent according to Rajabally et al.'s criteria (76/174, 43.7%). Fourteen patients' diagnoses made using Rajabally et al.'s criteria were shifted to the other subtype with the second electrodiagnostic examination. Of the 106 analyzed patients, 22 had immunoglobulin G anti-ganglioside antibodies (14 with the axonal subtype). They had less frequent sensory symptoms (54.5% vs. 83.1%, p = 0.009), a more frequent history of previous gastroenteritis (54.5% vs. 22.9%, p = 0.007), and a more severe disease as compared with those without antibodies., Interpretation: Serial electrodiagnostic examinations are more helpful for accurate subtype diagnosis of GBS because of the dynamic pathophysiology of the disease. We observed no significant increase in GBS frequency during the pandemic in this metropolis., (© 2024 Peripheral Nerve Society.)
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- 2024
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11. Warfarin vs doac: Comparative outcomes of mechanical thrombectomy for acute ischemic stroke in atrial fibrillation patients.
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Ramazanoglu L, Kalyoncu Aslan I, Akpinar A, Onal Y, Velioglu M, and Gozke E
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- Humans, Warfarin therapeutic use, Anticoagulants therapeutic use, Retrospective Studies, Thrombectomy adverse effects, Administration, Oral, Atrial Fibrillation complications, Atrial Fibrillation drug therapy, Atrial Fibrillation surgery, Ischemic Stroke drug therapy, Ischemic Stroke surgery, Ischemic Stroke complications, Stroke drug therapy, Stroke surgery, Stroke complications
- Abstract
Purpose: To compare outcomes of mechanical thrombectomy (MT) for acute ischemic stroke (AIS) in patients with atrial fibrillation (AF) taking warfarin or direct oral anticoagulants (DOACs)., Methods: A total of 71 consecutive patients with AF who underwent MT due to AIS between January 2018 and December 2021 were retrospectively analyzed. Patients were grouped as warfarin versus DOAC group. CHA
2 DS2 -VASc, HAS-BLED, The National Institutes of Health Stroke Scale (NIHSS) at the time of admission and at 24 h, successful recanalization, post- MT complications and technical properties of MT were evaluated. Patients were divided into a good prognosis group, and a mortality group according to the 90th day mRS., Results: HAS-BLED score was significantly higher in DOAC group (p = 0.006) There were no significant differences in stroke severity, successful recanalization rates, post-procedural complications and mRS 90th day scores between patients with warfarin and DOACs. CHA2 DS2 -VASc, NIHSS at admission and NIHSS on the 24th hour scores were significantly lower in the good mRS group (p = 0.012, p = 0.002, p < 0.001, respectively)., Conclusion: MT is safe and effective in patients receiving warfarin or DOACs. HASBLED and CHA2 DS2 -VASc scores can help to predict functional outcome after MT., Competing Interests: Conflict of interest The authors declare that they have no potential conflict of interest regarding the investigation, authorship, and/or publication of this article., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2023
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12. Prediction of Bleeding by the PRECISE-DAPT Score in Patients with Carotid Artery Stenting.
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Ramazanoglu L, Kalyoncu Aslan I, Bugrul A, Onal Y, Velioglu M, Topcuoglu OM, and Gozke E
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- Humans, Middle Aged, Aged, Platelet Aggregation Inhibitors therapeutic use, Retrospective Studies, Stents, Risk Assessment, Drug Therapy, Combination, Treatment Outcome, Hemorrhage chemically induced, Carotid Arteries, Carotid Stenosis diagnostic imaging, Carotid Stenosis surgery, Percutaneous Coronary Intervention adverse effects
- Abstract
Purpose: The predicting bleeding complications in patients undergoing stent implantation and the subsequent dual antiplatelet therapy (PRECISE-DAPT) score predicts the risk of bleeding in patients with dual antiplatelet therapy (DAPT) after percutaneous coronary interventions (PCIs). Patients with carotid artery stenting (CAS) are also treated with DAPT. In this study, we aimed to investigate the performance of the PRECISE-DAPT score in predicting bleeding in patients with CAS., Methods: Patients who had CAS between January 2018 and December 2020 were retrospectively enrolled. The PRECISE-DAPT score was calculated for each patient. The patients were divided into two groups based on their PRECISE-DAPT score: low < 25 and high ≥ 25. Bleeding and ischemia complications and laboratory data among the two groups were compared., Results: A total of 120 patients with a mean age of 67.3 ± 9.7 years were included. Forty-three patients had high PRECISE-DAPT scores, and 77 patients had low PRECISE-DAPT scores. Six patients developed bleeding events during the six-month follow-up, and five of them were in the PRECISE DAPT score ≥ 25 group. The difference between the two groups regarding bleeding events at six months was significant (P = 0.022)., Conclusion: The PRECISE-DAPT score might be used for predicting the bleeding risk in patients with CAS, and the bleeding rate was significantly higher in patients with a PRECISE-DAPT score ≥ 25., (© 2023. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).)
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- 2023
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13. Thrombectomy with or without Bridging Thrombolysis for Anterior Circulation Stroke.
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Ramazanoglu L, Kocak M, Aslan IK, Onal Y, Velioglu M, and Gozke E
- Subjects
- Humans, Thrombolytic Therapy methods, Retrospective Studies, Prospective Studies, Treatment Outcome, Thrombectomy adverse effects, Thrombectomy methods, Fibrinolytic Agents therapeutic use, Brain Ischemia complications, Stroke drug therapy, Stroke surgery, Stroke complications
- Abstract
Background: Currently, there is still no clear consensus on bridging thrombolysis (BT) before mechanical thrombectomy (MT). In this study, we aimed to compare clinical and procedural outcomes and complication rates of BT versus direct mechanical thrombectomy (d-MT) in anterior circulation stroke., Methods: A total of 359 consecutive anterior circulation stroke patients who received d-MT or BT in our tertiary stroke center between January 2018 and December 2020 were retrospectively analyzed. The patients were divided into two groups as Group d-MT (n = 210) and Group BT (n = 149). The primary outcome was the impact of BT on clinical and procedural outcomes, whereas the secondary outcome was the safety of BT., Results: The incidence of atrial fibrillation was higher in the d-MT group (p = 0.010). The median duration of the procedure was significantly higher in Group d-MT than in Group BT (35 vs 27 min, respectively; P = 0.044). The number of patients achieving good and excellent outcomes was significantly higher in Group BT (p = 0.006 and P = 0.03). The edema/malign infarction rate was higher in the d-MT group (p = 0.003). Successful reperfusion, first-pass effects, symptomatic intra-cranial hemorrhage, and mortality rates were similar between the groups (p > 0.05)., Conclusions: In this study, BT seems to yield better clinical and procedural outcomes with lower complication rates than d-MT. These findings may support the additional value of intravenous alteplase in anterior system strokes. Further large-scale, prospective, randomized-controlled studies will clarify the gray lines in this consensus, but this paper is important for reflecting the real-world data in developing countries., Competing Interests: None
- Published
- 2023
- Full Text
- View/download PDF
14. Delayed radiation-induced motor neuron syndrome: A case report.
- Author
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Giray E, Karayigit M, Senocak KC, Illeez OG, Ozkan FU, Aktas I, and Gozke E
- Subjects
- Male, Humans, Middle Aged, Motor Neurons, Electromyography methods, Diagnosis, Differential, Motor Neuron Disease complications, Motor Neuron Disease diagnosis, Radiculopathy etiology, Radiculopathy complications
- Abstract
Background: Delayed radiation-induced motor neuron syndrome (DRIMNS) is an atypical motor neuron disorder that develops months or years after radiation therapy. In this study we present a case of DRIMNS that developed forty years after radiotherapy and to discuss differential diagnoses., Case Presentation: A 56-year-old male patient was admitted to our clinic with complaints of increasing difficulty in walking for the past year. He had a history of operation and radiotherapy due to testicular tumor. Electroneuromyography (ENMG) and thoracic, lumbosacral, plexus and pelvic magnetic resonance imaging (MRI) were performed considering radiculopathy, plexopathy and motor neuron disease in the differential diagnosis. MRIs revealed no abnormality. Needle EMG of lower extremity and lumbar paraspinal muscles revealed fibrillation and positive sharp waves concomitant with fasciculations and reduced recruitment suggesting anterior horn cell/root involvement. DRIMNS was considered rather than motor neuron disease based on the long duration of symptoms with slow progressive course and history of radiotherapy to the pelvic region., Conclusion: DRIMNS is a rare entity that should be considered in the differential diagnosis of lower extremity muscle weakness in a patient with a history of malignancy and radiotherapy. EMG findings are very valuable in making the diagnosis together with the clinical picture.
- Published
- 2023
- Full Text
- View/download PDF
15. Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation.
- Author
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Gul SS and Gozke E
- Subjects
- Alcohol Drinking physiopathology, Atrial Fibrillation complications, Atrial Fibrillation physiopathology, Brain Ischemia complications, Brain Ischemia physiopathology, Female, Humans, Hypertension physiopathology, Male, Platelet Count, Risk Factors, Smoking physiopathology, Stroke complications, Stroke physiopathology, Atrial Fibrillation blood, Brain Ischemia blood, Mean Platelet Volume, Stroke blood
- Abstract
Background: Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). Methods: At Fatih Sultan Mehmet Training and Research Hospital, 297 patients diagnosed with acute ischemic stroke were included in the study and two groups were assigned as patients with and without NVAF. In the study, the relationship between MPV and platelet counts in the first 24 hours after the onset of the symptom between the two groups was examined. In addition, the relationship between MPV and hypertension, diabetes, coronary artery disease, smoking and alcohol use, infarct location, and use of antiplatelet or anticoagulant was assessed. Results: MPV levels were significantly higher in acute ischemic stroke patients with NVAF (p = 0.001; p < 0.01). The mean MPV level in patients with NVAF and non-smokers was significantly higher than smokers (p = 0.012; p < 0.05), but there was no significant relationship between MPV and other parameters. Conclusions: In this study, it was shown that MPV levels were significantly higher in patients with acute ischemic stroke and NVAF than those without NVAF. This finding suggested that MPV which shows platelet reactivity can be assumed as a risk factor of AIS in patients with NVAF.
- Published
- 2018
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16. New treatment alternatives in the ulnar neuropathy at the elbow: ultrasound and low-level laser therapy.
- Author
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Ozkan FU, Saygı EK, Senol S, Kapcı S, Aydeniz B, Aktaş İ, and Gozke E
- Subjects
- Adult, Cubital Tunnel Syndrome physiopathology, Evoked Potentials, Motor physiology, Evoked Potentials, Motor radiation effects, Female, Follow-Up Studies, Hand Strength physiology, Humans, Male, Middle Aged, Neural Conduction radiation effects, Patient Satisfaction, Single-Blind Method, Visual Analog Scale, Cubital Tunnel Syndrome diagnostic imaging, Cubital Tunnel Syndrome therapy, Low-Level Light Therapy methods, Ultrasonography
- Abstract
Ulnar nerve entrapment at the elbow (UNE) is the second most common entrapment neuropathy of the arm. Conservative treatment is the treatment of choice in mild to moderate cases. Elbow splints and avoiding flexion of the involved elbow constitute majority of the conservative treatment; indeed, there is no other non-invasive treatment modality. The aim of this study was to investigate the efficacy of ultrasound (US) and low-level laser therapy (LLLT) in the treatment of UNE to provide an alternative conservative treatment method. A randomized single-blind study was carried out in 32 patients diagnosed with UNE. Short-segment conduction study (SSCS) was performed for the localization of the entrapment site. Patients were randomized into US treatment (frequency of 1 MHz, intensity of 1.5 W/cm(2), continuous mode) and LLLT (0.8 J/cm(2) with 905 nm wavelength), both applied five times a week for 2 weeks. Assessments were performed at baseline, at the end of the treatment, and at the first and third months by visual analog scale, hand grip strength, semmes weinstein monofilament test, latency change at SSCS, and patient satisfaction scale. Both treatment groups had significant improvements on clinical and electrophysiological parameters (p < 0.05) at first month with no statistically significant difference between them. Improvements in all parameters were sustained at the third month for the US group, while only changes in grip strength and latency were significant for the LLLT group at third month. The present study demonstrated that both US and LLLT provided improvements in clinical and electrophysiological parameters and have a satisfying short-term effectiveness in the treatment of UNE.
- Published
- 2015
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17. Confocal scanning laser tomography of the optic nerve head on the patients with Alzheimer's disease compared to glaucoma and control.
- Author
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Kurna SA, Akar G, Altun A, Agirman Y, Gozke E, and Sengor T
- Subjects
- Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Microscopy, Confocal, Middle Aged, Nerve Fibers pathology, Ophthalmoscopy methods, Alzheimer Disease pathology, Glaucoma pathology, Optic Disk pathology, Tomography, Optical methods
- Abstract
The purpose of this study was to evaluate optic nerve head (ONH) differences of the patients with Alzheimer's disease (AD) measured by confocal scanning laser tomography [Heidelberg Retina Tomograph (HRT) III] and compare with glaucoma and control subjects. Eighty-four patients were enrolled into the study: 44 eyes of 24 patients with mild to moderate AD (Group 1), 68 eyes of 35 patients with glaucoma (Group 2), and 49 eyes of 25 heathy volunteers as a control (Group 3). A complete ophthalmologic examination as well as a confocal scanning laser ophthalmoscopic assessment with HRT III were performed on all patients. Mean values of the ONH topographic parameters such as rim area (RA), rim volume (RV), height variation contour, linear cup/disc ratio, cup shape measure, and retinal nerve fiber layer (RNFL) were recorded. Mean values of RNFL thickness was 0.23 ± 0.07 in AD, 0.22 ± 0.09 in glaucoma and 0.24 ± 0.07 in the control group (p = 0.323). RA and RV were significantly lower, and linear C/D ratio was significantly higher in the glaucoma group when compared to AD and control (p < 0.05). There was no statistically significant difference between AD and control for the optic disc parameters tested (p > 0.05). We observed a negative correlation of the age with RNFL in all of the groups (p < 0.005). Age was the most important parameter affecting RNFL. Our results suggest that HRT does not demonstrate ONH differences between AD and control group, while it successfully differentiates glaucoma from AD and control cases of older age.
- Published
- 2014
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18. Gamma-glutamyl transferase levels in patients with acute ischemic stroke.
- Author
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Gurbuzer N, Gozke E, and Ayhan Basturk Z
- Abstract
Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P < 0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P < 0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.
- Published
- 2014
- Full Text
- View/download PDF
19. An Observational Study on the Association between Migraines and Tension Type Headaches in Patients Diagnosed with Metabolic Syndrome.
- Author
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Gozke E, Unal M, Engin H, and Gurbuzer N
- Abstract
Background. Our aim was to investigate the association between migraine, tension type headache, and metabolic syndrome. Methods. Presence of tension type headache and migraine was investigated in 120 patients diagnosed as metabolic syndrome. The severity of the headache was recorded according to the visual analog scale. Results. Mean age of the patients was 54.41 ± 11.60 years (range, 29-84 yrs). Diagnoses of tension type headache and migraine without aura were made for 39 (32.5%) and 18 (15%) patients, respectively. Mean age of migraine patients was significantly lower relative to the patients with tension type headache and no headache. Incidence of hypertriglyceridemia was significantly higher in migraine patients when compared with cases tension type headache and without headache. In the tension type headache group, requirement for analgesics decreased as HDL cholesterol levels increased, while need for analgesic drugs increased in line with higher diastolic blood pressures. In the migraine group duration of headache was found to be prolonged with decreasing HDL cholesterol levels. Conclusion. In patients presenting with headache, its association with metabolic syndrome should be considered, and the patients should be especially observed with respect to response to analgesic and the presence of hypertension and hyperlipidemia.
- Published
- 2013
- Full Text
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20. Postcoital internal carotid artery dissection presenting as isolated painful horner syndrome: a case report.
- Author
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Gozke E, Tastekin Toz H, Kahraman Koytak P, and Alparslan F
- Abstract
Postcoital artery dissection is a rare condition. Here we report a 40-year-old male patient with painful Horner syndrome related to postcoital internal carotid artery (ICA) dissection. In neurologic examination of the patient, semiptosis, enophthalmus, and myosis were observed on the left side. There were no carotid bruits. On T1-weighted and fat-suppressed cranial MRI, hyperintensity consistent with intramural hematoma was observed within cervical and temporal petrous segments of left ICA. On cervical and cranial MRA, marked decrease in the calibration of C1 and C2 segments of the left ICA was remarkable. The patient was diagnosed as left ICA dissection and anticoagulant therapy was initiated. A prominent improvement was noted in clinical findings during two months of followup period.
- Published
- 2013
- Full Text
- View/download PDF
21. Ocular vestibular evoked myogenic potentials in patients with migraine.
- Author
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Gozke E, Erdal N, and Ozkarakas H
- Subjects
- Acoustic Stimulation, Adolescent, Adult, Electromyography methods, Female, Functional Laterality, Humans, Male, Middle Aged, Reaction Time physiology, Young Adult, Migraine Disorders physiopathology, Vestibular Evoked Myogenic Potentials physiology
- Abstract
Background: Subclinical cerebello-vestibular impairment has been described in migraine patients., Objectives: Our aim was to investigate the presence of subclinical vestibulopathy in migraine patients using ocular vestibular evoked myogenic potentials (oVEMP)., Patients and Methods: Forty-three patients suffering from migraine without aura who had no vestibular complaints and 29 healthy controls were included in the study. The responses were recorded from contralateral lower eyelid just above of the inferior oblique muscle during 120 dB click stimulation., Results: Eight migraine patients (18.6%) disclosed no response. Bilateral or unilateral response rates in the migraine group were 46.5% (n = 20) and 34.9% (n = 15) respectively. In controls, bilateral or unilateral responses could be obtained from 25 (86.7%), and 4 (13.2%) cases, respectively. In migraineurs group mean latencies of N1 and P1 were significantly longer, while N1-P1 amplitudes were found meaningfully lower., Conclusion: These data demonstrate that using oVEMP subclinical vestibular dysfunction can be elicited in migraine patients without vestibular complaints.
- Published
- 2010
22. Creutzfeldt-Jacob Disease: a case report.
- Author
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Gozke E, Erdal N, and Unal M
- Abstract
Introduction: Creutzfeldt-Jacob Disease is the most frequently seen type of prion diseases. Its clinical findings consist of predominantly progressive dementia with a rapid onset, myoclonus, and also cerebellar, pyramidal, extrapyramidal and visual signs. Definitive diagnosis is established with histological examination of brain biopsy or autopsy materials. Occurrence of periodical spikes in EEG, observation of cortical signal alterations during diffusion weighted (DW) MRI studies, and detection of protein 14-3-3 in cerebrospinal fluid (CSF) substantiate the diagnosis., Case Presentation: Seventy year-old male patient referred with complaints of weakness and involuntary movements in left arm, changes in behavior, and forgetfulness. He also developed akinetic mutism after nearly three months. In EEG periodic triphasic waves were seen. Despite the absence of any apparent pathological finding in T2 and FLAIR MRI, excluding signs of atrophy, on DW MRI hyperintense signal changes in cortical regions (cortical ribboning) were observed. Protein 14-3-3 in CSF was detected., Conclusion: Patients who have progressive dementia and associated atypical features should be investigated especially with DW MRI. Cortical ribboning is a very useful diagnostic sign for CJD.
- Published
- 2008
- Full Text
- View/download PDF
23. The evaluation of the tensor veli palatini muscle function with electromyography in chronic middle ear diseases.
- Author
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Sapci T, Mercangoz E, Evcimik MF, Karavus A, and Gozke E
- Subjects
- Adult, Chronic Disease, Female, Humans, Male, Middle Aged, Prospective Studies, Ear Diseases physiopathology, Electromyography, Eustachian Tube physiopathology, Muscle, Skeletal physiopathology
- Abstract
Unlabelled: Although there are several factors affecting the pathogenesis of chronic otitis, the pathological process has not been entirely defined yet. One of the theories suggested for the development of middle ear diseases is tubal dysfunction. The aim of the study is to analyze the function of the tensor veli palatini (TVP) muscle electromyographically in chronic middle ear pathologies and to evaluate the role of this muscle in eustachian tube dysfunction and pathogenesis of associated middle ear diseases by comparing with the results of healthy individuals., Study Design: A prospective, controlled, clinical trial. We enrolled 24 patients with chronic middle ear pathologies into our study and 18 controls without any previous ear problem. Electromyographic (EMG) needle was inserted into the TVP muscles in all patients transnasally. Functions of the TVP muscle were analyzed by using the amplitudes of the motor unit potential (MUP) and MUP durations detected on EMG. MUP amplitudes and MUP durations were compared statistically in all groups. When the mean MUP amplitudes and durations obtained from TVP muscles of all ears from the patient group were compared to the mean MUP amplitudes and durations obtained from healthy individuals, no statistically significant difference was observed between sick ears and control ears. Values obtained from the sick ears needed to be compared with mean values obtained from the control group separately, since absence of statistically significant difference cannot mean that we should ignore individual muscle dysfunction. The results we obtained from our study support that in the formation of different middle ear pathologies, myogenic defects in the eustachian tube have limited effects, except for existence of a predisposing factor like palate pathology. In all patients with chronic middle ear disease it is not appropriate to expect functional muscle dysfunction, however evaluation of TVP muscle function correctly may be helpful for bringing up the underlying possible muscle and nerve pathologies not in all patients.
- Published
- 2008
- Full Text
- View/download PDF
24. Sympathetic skin responses in patients with hyperthyroidism.
- Author
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Gozke E, Ozyurt Z, Dortcan N, Ore O, Kocer A, and Ozer E
- Subjects
- Adolescent, Adult, Aged, Autonomic Nervous System Diseases diagnosis, Female, Humans, Hyperthyroidism diagnosis, Male, Middle Aged, Autonomic Nervous System Diseases physiopathology, Electric Stimulation methods, Electromyography methods, Hyperthyroidism physiopathology, Skin innervation, Skin physiopathology, Sympathetic Nervous System physiopathology
- Abstract
Background: The aim of this study was to investigate the disorders of sympathetic nervous system in patients with hyperthyroidism using sympathetic skin response (SSR)., Material and Methods: Twenty-two newly diagnosed cases with hyperthyroidism were included in the study. The results were compared with those of 20 healthy controls. SSR was recorded with the contralateral electrical stimulation of the median nerve (of the upper extremities) and tibial nerve (of the lower extremities) with active electrodes placed on palms and soles and reference electrodes attached on the dorsal aspects of hands and feet., Results: Ages of the cases with hyperthyroidism and controls ranged between 15-65 years (mean: 46.7 +/- 15.0 years) and 24-62 years (mean: 39.6 +/- 9.8 years) respectively (p > 0.05). In all the control subjects SSR could be obtained, while from the lower extremities of 4 cases with hyperthyroidism (18.0%) SSR could not be elicited. Mean SSR latencies of lower extremities were found significantly longer than control group (p < 0. 05). No difference was detected between mean amplitudes of SSR in upper and lower extremities., Conclusion: These findings suggest that SSR is useful for investigation of sympathetic nervous system involvement in cases with hyperthyroidism.
- Published
- 2007
25. Primary orthostatic tremor: analysis of three cases.
- Author
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Gozke E, Ore O, Ozyurt Z, and Cetinkaya M
- Subjects
- Aged, Electromyography, Female, Humans, Muscle, Skeletal physiology, Posture, Weight-Bearing, Leg physiology, Tremor physiopathology
- Abstract
Primary orthostatic tremor (POT) is a rare form of tremor characterized by unsteadiness and quivering of lower extremities while standing. These symptoms relieve when sitting or reclining It is much less apparent when leaning against an object or during walking. The rhythmic tremor activity with a frequency of 13-18 Hz can be obtained electromyography recordings. Here we report three cases that have typical clinical and electrophysiological findings of POT.
- Published
- 2004
26. Cranial magnetic resonance imaging findings in patients with migraine.
- Author
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Gozke E, Ore O, Dortcan N, Unal Z, and Cetinkaya M
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Migraine with Aura pathology, Brain pathology, Magnetic Resonance Imaging, Migraine Disorders pathology
- Abstract
Objective: To investigate the frequency of cranial magnetic resonance imaging abnormalities in patients with migraine and their relationship to type, duration, and frequency of migraine attacks., Methods: Forty-five patients (43 women, 2 men) with migraine whose ages ranged between 19 and 53 years (mean, 40.91 [SD, 7.69]) were evaluated. Of the 45 patients, 20 had migraine with aura and 25 had migraine without aura, according to the diagnostic criteria of the International Headache Society., Results: In 13 (28.8%) of 45 patients, white matter foci were present on magnetic resonance imaging. Eight of these patients (61.5%) had migraine with aura, and 5 patients (38.4%) had migraine without aura. The presence of white matter foci was significantly higher in the patients with aura (8 [40%] of 20) than in those without aura (5 [20%] of 25). It was found that as the frequency of attacks per month increased, the number of patients with white matter foci also increased. Although the mean duration of migraine was longer in patients with white matter foci (149.5 months [SD, 87.9]) than in those without white matter foci (134.1 months [SD, 88.3]), there was no significant difference (P >.05)., Conclusion: Although there are no specific magnetic resonance imaging findings peculiar to migraine, detection of white matter foci should be taken into consideration in patients with migraine (especially migraine with aura). Frequency of attacks is an important indicator of existence of white matter foci.
- Published
- 2004
- Full Text
- View/download PDF
27. Sympathetic skin response and R-R interval variation in cases with rheumatoid arthritis.
- Author
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Gozke E, Erdogan N, Akyuz G, Turan B, Akyuz E, and Us O
- Subjects
- Adult, Aged, Electromyography, Female, Foot innervation, Foot physiology, Hand innervation, Hand physiology, Humans, Median Nerve physiopathology, Middle Aged, Respiratory Physiological Phenomena, Rest physiology, Skin innervation, Tibial Nerve physiopathology, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid physiopathology, Autonomic Nervous System Diseases complications, Autonomic Nervous System Diseases physiopathology, Reaction Time physiology, Skin physiopathology, Sympathetic Nervous System physiopathology
- Abstract
To investigate the autonomic nervus system involvement in cases with rheumatoid arthritis (RA) by assesing sympathetic skin response (SSR) and R-R interval variation (RRIV), 14 healthy women and 10 women with RA, all of them without clinic dysautonomies were examined. SSR's were recorded palmar surface of both hands and soles of both feet, after stimulating median and tibial nerves individually. RRIV's were assessed at rest and during six deep breathing in one minute with electrodes placed on dorsal surfaces of both hands. SSR could not be obtained from lower extremities of one case with RA. We could not find any significant difference between two groups in terms of SSR latencies. RRIV values obtained during deep breathing to those recorded at rest (D%/R%) was found to be significantly lower in RA cases than healthy controls. RRIV values increased with deep breathing in healthy subjects, while they decreased in 50% of the RA cases. We conclude that assessment of SSR and RRIV are valuble methods for revelation of subclinical autonomic involvement in cases with RA.
- Published
- 2003
28. A-waves and electrophysiologically established diagnoses.
- Author
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Gozke E, Celebi D, Dortcan N, Deniz E, Us O, and Akyuz G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Reaction Time physiology, Transcutaneous Electric Nerve Stimulation, Electrophysiology, Motor Neurons physiology, Radiculopathy physiopathology
- Abstract
The aim of this study was to investigate the presence of A-waves in cases referred to our electromyography laboratory with various diagnoses and documentation of electrophysiologic diagnoses with A-waves. In cases where at least 3 motor nerves were analysed, during F response studies, A-waves having stabile latencies and amplitudes from minimum one third of submaximal and supramaximal stimuli were evaluated. Electrophysiologic diagnoses and the related nerves of cases with A-waves were recorded. A-waves were obtained from 38 out of 1604 cases (2.36%). Most of the cases (57.8%) with established A-waves consisted of patients with radiculopathies. A-waves were detected mostly in tibial nerve. Electrophysiologic analysis of 5 cases with A-waves has given normal results. Although mechanism of A-waves is not known completely, we suggest when obtained it must be remarked during routine electrophysiologic examination.
- Published
- 2003
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