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1. Long-term mortality and health-related quality of life with lower versus higher oxygenation targets in intensive care unit patients with COVID-19 and severe hypoxaemia

Author

Crescioli, Elena, Nielsen, Frederik Mølgaard, Bunzel, Anne-Marie, Eriksen, Anne Sofie Broberg, Siegemund, Martin, Poulsen, Lone Musaeus, Andreasen, Anne Sofie, Bestle, Morten Heiberg, Iversen, Susanne Andi, Brøchner, Anne Craveiro, Grøfte, Thorbjørn, Hildebrandt, Thomas, Laake, Jon Henrik, Kjær, Maj-Brit Nørregaard, Lange, Theis, Perner, Anders, Klitgaard, Thomas Lass, Schjørring, Olav Lilleholt, and Rasmussen, Bodil Steen

Published
2024
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2. Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial

Author

Asfar, Pierre, Nay, Mai-Anh, Guitton, Christophe, Quenot, Jean-Pierre, Tran-Van, David, Bohe, Julien, Plantefève, Gaëtan, Nseir, Saadalla, Lefrant, Jean-Yves, Monnet, Xavier, Papazian, Laurent, Vinsonneau, Christophe, Constantin, Jean-Michel, Mebazaa, Alexandre, Oueslati, Haikel, Escudero, Dolores, Martinez Sagasti, Fernando, Piacentini, Enrique, Ramirez Galleymore, Paula, Dugernier, Thierry, Fagnoul, David, Michaux, Isabelle, Seibert, Allan, Reinikainen, Matti, Grøfte, Thorbjørn, Martin-Loeches, Ignacio, Laffey, John, François, Bruno, Lambden, Simon, Fivez, Tom, Gibot, Sebastien, Derive, Marc, Grouin, Jean-Marie, Salcedo-Magguilli, Margarita, Lemarié, Jérémie, De Schryver, Nicolas, Jalkanen, Ville, Hicheur, Tarik, Garaud, Jean-Jacques, Cuvier, Valérie, Ferrer, Ricard, Bestle, Morten, Pettilä, Ville, Mira, Jean-Paul, Bouisse, Camille, Mercier, Emmanuelle, Vermassen, Joris, Huberlant, Vincent, Vinatier, Isabelle, Anguel, Nadia, Levy, Mitchell, and Laterre, Pierre-François

Published
2023
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3. Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia

Author

Crescioli, Elena, Klitgaard, Thomas Lass, Poulsen, Lone Musaeus, Brand, Bjørn Anders, Siegemund, Martin, Grøfte, Thorbjørn, and Keus, Frederik

Subjects
Analysis, Health aspects, Mortality -- Denmark -- United Kingdom, Hospital patients -- Analysis -- Health aspects, Medical research -- Analysis -- Health aspects, Medicine, Experimental -- Analysis -- Health aspects
Abstract

Author(s): Elena Crescioli [sup.1] [sup.2] [sup.3], Thomas Lass Klitgaard [sup.1] [sup.2] [sup.3], Lone Musaeus Poulsen [sup.4], Bjørn Anders Brand [sup.5], Martin Siegemund [sup.6], Thorbjørn Grøfte [sup.7], Frederik Keus [sup.8], Ulf [...], Purpose We assessed outcomes after 1 year of lower versus higher oxygenation targets in intensive care unit (ICU) patients with severe hypoxaemia. Methods Pre-planned analyses evaluating 1-year mortality and health-related quality-of-life (HRQoL) outcomes in the previously published Handling Oxygenation Targets in the ICU trial which randomised 2928 adults with acute hypoxaemia to targets of arterial oxygen of 8 kPa or 12 kPa throughout the ICU stay up to 90 days. One-year all-cause mortality was assessed in the intention-to-treat population. HRQoL was assessed using EuroQol 5 dimensions 5 levels (EQ-5D-5L) questionnaire and EQ visual analogue scale score (EQ-VAS), and analyses were conducted in both survivors only and the intention-to-treat population with assignment of the worst scores to deceased patients. Results We obtained 1-year vital status for 2887/2928 (98.6%), and HRQoL for 2600/2928 (88.8%) of the trial population. One year after randomisation, 707/1442 patients (49%) in the lower oxygenation group vs. 704/1445 (48.7%) in the higher oxygenation group had died (adjusted risk ratio 1.00; 95% confidence interval 0.93-1.08, p = 0.92). In total, 1189/1476 (80.4%) 1-year survivors participated in HRQoL interviews: median EQ-VAS scores were 65 (interquartile range 50-80) in the lower oxygenation group versus 67 (50-80) in the higher oxygenation group (p = 0.98). None of the five EQ-5D-5L dimensions differed between groups. Conclusion Among adult ICU patients with severe hypoxaemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa).

Published
2022
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4. Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19:The HOT-COVID Randomized Clinical Trial

Author

Nielsen, Frederik M, Klitgaard, Thomas L, Siegemund, Martin, Laake, Jon H, Thormar, Katrin M, Cole, Jade M, Aagaard, Søren R, Bunzel, Anne-Marie G, Vestergaard, Stine R, Langhoff, Peter K, Pedersen, Caroline H, Hejlesen, Josefine Ø, Abdelhamid, Salim, Dietz, Anna, Gebhard, Caroline E, Zellweger, Nuria, Hollinger, Alexa, Poulsen, Lone M, Weihe, Sarah, Andersen-Ranberg, Nina C, Pedersen, Ulf G, Mathiesen, Ole, Andreasen, Anne Sofie, Brix, Helene, Thomsen, Jonas J, Petersen, Christina H, Bestle, Morten H, Wichmann, Sine, Lund, Martin S, Mortensen, Karoline M, Brand, Björn A, Haase, Nicolai, Iversen, Susanne A, Marcussen, Klaus V, Brøchner, Anne C, Borup, Morten, Grøfte, Thorbjørn, Hildebrandt, Thomas, Kjær, Maj-Brit N, Engstrøm, Janus, Lange, Theis, Perner, Anders, Schjørring, Olav L, Rasmussen, Bodil S, Nielsen, Frederik M, Klitgaard, Thomas L, Siegemund, Martin, Laake, Jon H, Thormar, Katrin M, Cole, Jade M, Aagaard, Søren R, Bunzel, Anne-Marie G, Vestergaard, Stine R, Langhoff, Peter K, Pedersen, Caroline H, Hejlesen, Josefine Ø, Abdelhamid, Salim, Dietz, Anna, Gebhard, Caroline E, Zellweger, Nuria, Hollinger, Alexa, Poulsen, Lone M, Weihe, Sarah, Andersen-Ranberg, Nina C, Pedersen, Ulf G, Mathiesen, Ole, Andreasen, Anne Sofie, Brix, Helene, Thomsen, Jonas J, Petersen, Christina H, Bestle, Morten H, Wichmann, Sine, Lund, Martin S, Mortensen, Karoline M, Brand, Björn A, Haase, Nicolai, Iversen, Susanne A, Marcussen, Klaus V, Brøchner, Anne C, Borup, Morten, Grøfte, Thorbjørn, Hildebrandt, Thomas, Kjær, Maj-Brit N, Engstrøm, Janus, Lange, Theis, Perner, Anders, Schjørring, Olav L, and Rasmussen, Bodil S

Abstract

Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting a Pao2 of 60 mm Hg vs 90 mm Hg in patients with COVID-19 and severe hypoxemia in the intensive care unit (ICU). Design, Setting, and Participants Multicenter randomized clinical trial including 726 adults with COVID-19 receiving at least 10 L/min of oxygen or mechanical ventilation in 11 ICUs in Europe from August 2020 to March 2023. The trial was prematurely stopped prior to outcome assessment due to slow enrollment. End of 90-day follow-up was June 1, 2023. Interventions Patients were randomized 1:1 to a Pao2 of 60 mm Hg (lower oxygenation group; n = 365) or 90 mm Hg (higher oxygenation group; n = 361) for up to 90 days in the ICU. Main Outcomes and Measures The primary outcome was the number of days alive without life support (mechanical ventilation, circulatory support, or kidney replacement therapy) at 90 days. Secondary outcomes included mortality, proportion of patients with serious adverse events, and number of days alive and out of hospital, all at 90 days. Results Of 726 randomized patients, primary outcome data were available for 697 (351 in the lower oxygenation group and 346 in the higher oxygenation group). Median age was 66 years, and 495 patients (68%) were male. At 90 days, the median number of days alive without life support was 80.0 days (IQR, 9.0-89.0 days) in the lower oxygenation group and 72.0 days (IQR, 2.0-88.0 days) in the higher oxygenation group (P = .009 by van Elteren test; supplemental bootstrapped adjusted mean difference, 5.8 days [95% CI, 0.2-11.5 days]; P = .04). Mortality at 90 days was 30.2% in the lower oxygenation group and 34.7% in the higher oxygenation group (risk ratio, 0.86 [98.6% CI, 0.66-1.13]; P = .18). There were no statistically significant differences in proportion of patients with serious adver, IMPORTANCE: Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial.OBJECTIVE: To assess the effects of targeting a Pao2 of 60 mm Hg vs 90 mm Hg in patients with COVID-19 and severe hypoxemia in the intensive care unit (ICU).DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized clinical trial including 726 adults with COVID-19 receiving at least 10 L/min of oxygen or mechanical ventilation in 11 ICUs in Europe from August 2020 to March 2023. The trial was prematurely stopped prior to outcome assessment due to slow enrollment. End of 90-day follow-up was June 1, 2023.INTERVENTIONS: Patients were randomized 1:1 to a Pao2 of 60 mm Hg (lower oxygenation group; n = 365) or 90 mm Hg (higher oxygenation group; n = 361) for up to 90 days in the ICU.MAIN OUTCOMES AND MEASURES: The primary outcome was the number of days alive without life support (mechanical ventilation, circulatory support, or kidney replacement therapy) at 90 days. Secondary outcomes included mortality, proportion of patients with serious adverse events, and number of days alive and out of hospital, all at 90 days.RESULTS: Of 726 randomized patients, primary outcome data were available for 697 (351 in the lower oxygenation group and 346 in the higher oxygenation group). Median age was 66 years, and 495 patients (68%) were male. At 90 days, the median number of days alive without life support was 80.0 days (IQR, 9.0-89.0 days) in the lower oxygenation group and 72.0 days (IQR, 2.0-88.0 days) in the higher oxygenation group (P = .009 by van Elteren test; supplemental bootstrapped adjusted mean difference, 5.8 days [95% CI, 0.2-11.5 days]; P = .04). Mortality at 90 days was 30.2% in the lower oxygenation group and 34.7% in the higher oxygenation group (risk ratio, 0.86 [98.6% CI, 0.66-1.13]; P = .18). There were no statistically significant differences in proportion of patients with serious adverse eve

Published
2024

6. Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial

Author

François, Bruno, primary, Lambden, Simon, additional, Fivez, Tom, additional, Gibot, Sebastien, additional, Derive, Marc, additional, Grouin, Jean-Marie, additional, Salcedo-Magguilli, Margarita, additional, Lemarié, Jérémie, additional, De Schryver, Nicolas, additional, Jalkanen, Ville, additional, Hicheur, Tarik, additional, Garaud, Jean-Jacques, additional, Cuvier, Valérie, additional, Ferrer, Ricard, additional, Bestle, Morten, additional, Pettilä, Ville, additional, Mira, Jean-Paul, additional, Bouisse, Camille, additional, Mercier, Emmanuelle, additional, Vermassen, Joris, additional, Huberlant, Vincent, additional, Vinatier, Isabelle, additional, Anguel, Nadia, additional, Levy, Mitchell, additional, Laterre, Pierre-François, additional, Asfar, Pierre, additional, Nay, Mai-Anh, additional, Guitton, Christophe, additional, Quenot, Jean-Pierre, additional, Tran-Van, David, additional, Bohe, Julien, additional, Plantefève, Gaëtan, additional, Nseir, Saadalla, additional, Lefrant, Jean-Yves, additional, Monnet, Xavier, additional, Papazian, Laurent, additional, Vinsonneau, Christophe, additional, Constantin, Jean-Michel, additional, Mebazaa, Alexandre, additional, Oueslati, Haikel, additional, Escudero, Dolores, additional, Martinez Sagasti, Fernando, additional, Piacentini, Enrique, additional, Ramirez Galleymore, Paula, additional, Dugernier, Thierry, additional, Fagnoul, David, additional, Michaux, Isabelle, additional, Seibert, Allan, additional, Reinikainen, Matti, additional, Grøfte, Thorbjørn, additional, Martin-Loeches, Ignacio, additional, and Laffey, John, additional

Published
2023
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11. Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm

Author

Rasmussen, Anders Mølgaard, primary, Toft, Mette Helene, additional, Awada, Hussein Nasser, additional, Dirks, Jesper, additional, Brandsborg, Birgitte, additional, Rasmussen, Line Kirkegaard, additional, Kirkegaard, Ellen, additional, Hasfeldt-Hansen, Dorthe, additional, Larsen, Thomas Egemose, additional, Charalampidis, Georgios, additional, Mørk, Emilie Louise Schjøtt, additional, Rosager, Chirstine Linaa, additional, Salam, Idress Ahmad, additional, Rasmussen, Bodil Steen, additional, Jørgensen, Marlene, additional, Skjønnemand, Martin, additional, Lund, Caterina Amanti, additional, Schroder, Save, additional, Sørensen, Johan Kløvgaard, additional, Sølling, Christoffer, additional, Hansen, Kristian Kraft, additional, Rasmussen, Christina Kirkegaard, additional, Steen, Nick Phaff, additional, Nielsen, Anne Staal, additional, Geisler, Anja, additional, Køppen, Kasper Storm, additional, Pælestik, Maria Bolther, additional, Grøfte, Thorbjørn, additional, Meyhoff, Christian Sylvest, additional, Kroh, Charlotte Loumann, additional, Christensen, Amalie Prien, additional, Haugstvedt, Aleksander Fjeld, additional, Hansen, Maria Aagaard, additional, Nielsen, Christian Viggo, additional, Dybdal, Bitten, additional, Falcon, Lars, additional, Hägi-Pedersen, Daniel, additional, Jauho, Kristian, additional, Wolsted, Henrik, additional, Pedersen, Christian Alves Kohler, additional, Sommer, Trine Nyboe, additional, Kromberg, Laurits Schou, additional, Kristensen, Danja Lykke, additional, Svensson, Camilla Kara, additional, Nielsen, Hans Fjeldsøe, additional, Sørensen, Martin Kryspin, additional, Jacobsen, Stig, additional, Sundskard, Martin, additional, Brahe, Nicole, additional, Jakobsen, Karina, additional, Jensen, Mette Skov, additional, Odder, Lillian, additional, Selter, Hansjörg, additional, Mohr, Tróndur Høgnason, additional, Jensen, Elin H, additional, Jensen, Pernille Pia, additional, Skjold, Christine, additional, and Aasvang, Eske Kvanner, additional

Published
2021
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12. Handling oxygenation targets in ICU patients with COVID‐19—Protocol and statistical analysis plan in the HOT‐COVID trial

Author

Mølgaard Nielsen, Frederik, primary, Lass Klitgaard, Thomas, additional, Crescioli, Elena, additional, Rosborg Aagaard, Søren, additional, Andreasen, Anne Sofie, additional, Musaeus Poulsen, Lone, additional, Siegemund, Martin, additional, Craveiro Brøchner, Anne, additional, Bestle, Morten H., additional, Andi Iversen, Susanne, additional, Brand, Björn A., additional, Laake, Jon Henrik, additional, Grøfte, Thorbjørn, additional, Hildebrandt, Thomas, additional, Lange, Theis, additional, Perner, Anders, additional, Lilleholt Schjørring, Olav, additional, and Steen Rasmussen, Bodil, additional

Published
2021
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13. Handling oxygenation targets in ICU patients with COVID-19—Protocol and statistical analysis plan in the HOT-COVID trial

Author

Mølgaard Nielsen, Frederik, Lass Klitgaard, Thomas, Crescioli, Elena, Rosborg Aagaard, Søren, Andreasen, Anne Sofie, Musaeus Poulsen, Lone, Siegemund, Martin, Craveiro Brøchner, Anne, Bestle, Morten H., Andi Iversen, Susanne, Brand, Björn A., Laake, Jon Henrik, Grøfte, Thorbjørn, Hildebrandt, Thomas, Lange, Theis, Perner, Anders, Lilleholt Schjørring, Olav, Steen Rasmussen, Bodil, Mølgaard Nielsen, Frederik, Lass Klitgaard, Thomas, Crescioli, Elena, Rosborg Aagaard, Søren, Andreasen, Anne Sofie, Musaeus Poulsen, Lone, Siegemund, Martin, Craveiro Brøchner, Anne, Bestle, Morten H., Andi Iversen, Susanne, Brand, Björn A., Laake, Jon Henrik, Grøfte, Thorbjørn, Hildebrandt, Thomas, Lange, Theis, Perner, Anders, Lilleholt Schjørring, Olav, and Steen Rasmussen, Bodil

Published
2021

14. Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm

Author

Rasmussen, Anders Mølgaard, Toft, Mette Helene, Awada, Hussein Nasser, Dirks, Jesper, Brandsborg, Birgitte, Rasmussen, Line Kirkegaard, Kirkegaard, Ellen, Hasfeldt-hansen, Dorthe, Larsen, Thomas Egemose, Charalampidis, Georgios, Mørk, Emilie Louise Schjøtt, Rosager, Chirstine Linaa, Salam, Idress Ahmad, Rasmussen, Bodil Steen, Jørgensen, Marlene, Skjønnemand, Martin, Lund, Caterina Amanti, Schroder, Save, Sørensen, Johan Kløvgaard, Sølling, Christoffer, Hansen, Kristian Kraft, Rasmussen, Christina Kirkegaard, Steen, Nick Phaff, Nielsen, Anne Staal, Geisler, Anja, Køppen, Kasper Storm, Pælestik, Maria Bolther, Grøfte, Thorbjørn, Meyhoff, Christian Sylvest, Kroh, Charlotte Loumann, Christensen, Amalie Prien, Haugstvedt, Aleksander Fjeld, Hansen, Maria Aagaard, Nielsen, Christian Viggo, Dybdal, Bitten, Falcon, Lars, Hägi-pedersen, Daniel, Jauho, Kristian, Wolsted, Henrik, Pedersen, Christian Alves Kohler, Sommer, Trine Nyboe, Kromberg, Laurits Schou, Kristensen, Danja Lykke, Svensson, Camilla Kara, Nielsen, Hans Fjeldsøe, Sørensen, Martin Kryspin, Jacobsen, Stig, Sundskard, Martin, Brahe, Nicole, Jakobsen, Karina, Jensen, Mette Skov, Odder, Lillian, Selter, Hansjörg, Mohr, Tróndur Høgnason, Jensen, Elin H, Jensen, Pernille Pia, Skjold, Christine, Aasvang, Eske Kvanner, Rasmussen, Anders Mølgaard, Toft, Mette Helene, Awada, Hussein Nasser, Dirks, Jesper, Brandsborg, Birgitte, Rasmussen, Line Kirkegaard, Kirkegaard, Ellen, Hasfeldt-hansen, Dorthe, Larsen, Thomas Egemose, Charalampidis, Georgios, Mørk, Emilie Louise Schjøtt, Rosager, Chirstine Linaa, Salam, Idress Ahmad, Rasmussen, Bodil Steen, Jørgensen, Marlene, Skjønnemand, Martin, Lund, Caterina Amanti, Schroder, Save, Sørensen, Johan Kløvgaard, Sølling, Christoffer, Hansen, Kristian Kraft, Rasmussen, Christina Kirkegaard, Steen, Nick Phaff, Nielsen, Anne Staal, Geisler, Anja, Køppen, Kasper Storm, Pælestik, Maria Bolther, Grøfte, Thorbjørn, Meyhoff, Christian Sylvest, Kroh, Charlotte Loumann, Christensen, Amalie Prien, Haugstvedt, Aleksander Fjeld, Hansen, Maria Aagaard, Nielsen, Christian Viggo, Dybdal, Bitten, Falcon, Lars, Hägi-pedersen, Daniel, Jauho, Kristian, Wolsted, Henrik, Pedersen, Christian Alves Kohler, Sommer, Trine Nyboe, Kromberg, Laurits Schou, Kristensen, Danja Lykke, Svensson, Camilla Kara, Nielsen, Hans Fjeldsøe, Sørensen, Martin Kryspin, Jacobsen, Stig, Sundskard, Martin, Brahe, Nicole, Jakobsen, Karina, Jensen, Mette Skov, Odder, Lillian, Selter, Hansjörg, Mohr, Tróndur Høgnason, Jensen, Elin H, Jensen, Pernille Pia, Skjold, Christine, and Aasvang, Eske Kvanner

Abstract

Background Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative pain in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed to describe the occurrence and severity of immediate postoperative pain in a large, unselected cohort. Methods This was a prospective cohort study, encompassing all procedures in 31 public hospitals in the Danish Realm, during a 5-day period including the weekend. Data on procedures and anesthesia were collected and the main outcome was occurrence of moderate or severe pain in the OR. Secondary outcomes included pain, sedation and nausea in the OR or during the first 15 min in the postanesthesia care unit (PACU) including relevant risk factors. Descriptive and logistic regression statistics were used. Results A total of 3675 procedures were included for analysis (87% inclusion rate). Moderate or severe pain occurred in 7.4% (95% CI 6.5% to 8.3%) of cases in the OR immediately after awakening, rising to 20.2% in the OR and/or PACU. Large intraprocedure and interprocedure variations occurred (0.0%–37.5%), and in 20% of cases with epidural-general anesthesia patients experienced moderate or severe pain. Independent risk factors were female sex, younger age, preoperative pain, daily opioid use and major surgical procedures. Conclusion Moderate or severe pain in the immediate postoperative phase occurred in 20% of all cases with procedure and anesthesiological technique variations, suggesting a need for identification of relevant procedure-specific risk factors and development of preventive treatments.

Published
2021

16. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

Author

Schjørring, Olav L., primary, Klitgaard, Thomas L., additional, Perner, Anders, additional, Wetterslev, Jørn, additional, Lange, Theis, additional, Siegemund, Martin, additional, Bäcklund, Minna, additional, Keus, Frederik, additional, Laake, Jon H., additional, Morgan, Matthew, additional, Thormar, Katrin M., additional, Rosborg, Søren A., additional, Bisgaard, Jannie, additional, Erntgaard, Annette E.S., additional, Lynnerup, Anne-Sofie H., additional, Pedersen, Rasmus L., additional, Crescioli, Elena, additional, Gielstrup, Theis C., additional, Behzadi, Meike T., additional, Poulsen, Lone M., additional, Estrup, Stine, additional, Laigaard, Jens P., additional, Andersen, Cheme, additional, Mortensen, Camilla B., additional, Brand, Björn A., additional, White, Jonathan, additional, Jarnvig, Inge-Lise, additional, Møller, Morten H., additional, Quist, Lars, additional, Bestle, Morten H., additional, Schønemann-Lund, Martin, additional, Kamper, Maj K., additional, Hindborg, Mathias, additional, Hollinger, Alexa, additional, Gebhard, Caroline E., additional, Zellweger, Núria, additional, Meyhoff, Christian S., additional, Hjort, Mathias, additional, Bech, Laura K., additional, Grøfte, Thorbjørn, additional, Bundgaard, Helle, additional, Østergaard, Lars H.M., additional, Thyø, Maria A., additional, Hildebrandt, Thomas, additional, Uslu, Bülent, additional, Sølling, Christoffer G., additional, Møller-Nielsen, Nette, additional, Brøchner, Anne C., additional, Borup, Morten, additional, Okkonen, Marjatta, additional, Dieperink, Willem, additional, Pedersen, Ulf G., additional, Andreasen, Anne S., additional, Buus, Lone, additional, Aslam, Tayyba N., additional, Winding, Robert R., additional, Schefold, Joerg C., additional, Thorup, Stine B., additional, Iversen, Susanne A., additional, Engstrøm, Janus, additional, Kjær, Maj-Brit N., additional, and Rasmussen, Bodil S., additional

Published
2021
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30. Prehospital triage of patients suffering severe dyspnoea using N-terminal pro-brain natriuretic peptide, the PreBNP trial: a randomised controlled clinical trial

Author

Bøtker, Morten T, primary, Jørgensen, Maren T, additional, Stengaard, Carsten, additional, Seidenfaden, Sophie-Charlott, additional, Tarpgaard, Mona, additional, Granfeldt, Asger, additional, Mortensen, Tanja Ø, additional, Grøfte, Thorbjørn, additional, Friesgaard, Kristian D, additional, Mærkedahl, Rikke, additional, Pedersen, Anette B, additional, Lundorff, Simon, additional, Hansen, Troels Martin, additional, Kirkegaard, Hans, additional, Christensen, Erika F, additional, and Terkelsen, Christian J, additional

Published
2017
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32. Pneumothorax med respirationssynkron unilateral mammahævelse

Author

Skaarup, Søren Helbo and Grøfte, Thorbjørn

Subjects
Adult, Rib Fractures/diagnostic imaging, Pneumothorax/diagnosis, Breast Implants, Accidents, Traffic, Humans, Female, skin and connective tissue diseases, Flail Chest/etiology
Abstract

Women with breast implants constitute a growing proportion of the female population in Denmark. Thoracic trauma can result in a different pathology and clinical presentation compared with women without breast implants. This case report illustrates an atypical manifestation of pneumothorax in a breast augmented woman who suffered thoracic trauma with communication between the thorax cavity and the space around the implant.

Published
2014

35. Effects of insulin-like growth factor-I administration on in vivo regulation of urea synthesis in normal subjects and patients with cirrhosis

Author

Sandahl, Thomas D, Aagaard, Niels K, Thomsen, Karen L, Grøfte, Thorbjørn, Greisen, Jacob, Christiansen, Jens S, and Vilstrup, Hendrik

Abstract

Udgivelsesdato: 2010-Oct-29 Background: The anabolic effects of insulin-like growth factor-I (IGF-I) may involve a decrease of hepatic nitrogen (N) clearance, but this has never been studied in humans. Patients with cirrhosis have low levels of IGF-I and might benefit from IGF-I therapy. Conversely, a possible decrease in hepatic N clearance by IGF-I could increase the risk of hepatic encephalopathy. Aims: To examine the effects of 1-week IGF-I administration on the functional hepatic N clearance (FHNC), viz. the linear slope of the relationship between blood-α-amino-N concentration and urea-N synthesis rate as controlled by an infusion of alanine. Methods: A randomized sequence-crossover placebo-controlled study. Eight healthy volunteers and eight patients with alcoholic cirrhosis received injections of saline or IGF-I twice daily (50 μg/kg) for 7 days. Results: IGF-I levels at baseline were lower in the patients than those in the controls. The IGF-I treatment normalized patient levels and caused an increase in the controls to supra-physiological levels. FHNC was lower in patients compared with healthy subjects (23.0 vs 36.5 L/h, P=0.03). IGF-I treatment reduced FHNC by 30% in healthy subjects (from 36.5 to 25.7 L/h, P=0.02), whereas no effect was found in the patients. Conclusion: IGF-I downregulates urea synthesis in normal subjects. This may be part of the explanation behind the anabolic effects of IGF-I. The normalization of IGF-I in cirrhosis patients without an effect on urea synthesis implies that the patients were resistant to IGF-I with regard to reduction of hepatic amino-N elimination. IGF-I treatment of cirrhosis patients evidently carries no risk of N accumulation.

Published
2011
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36. Abstract 16229: The Performance of Dispatcher Assisted Cardiopulmonary Resuscitation Among Elderly Laypersons is Inferior Compared to Young Laypersons: A Simulation Study

Author

Nebsbjerg, Mette A, primary, Rasmussen, Stinne E, additional, Bjørnshave, Katrine, additional, Krogh, Lise Q, additional, Krogh, Kristian, additional, Povlsen, Jonas A, additional, Riddervold, Ingunn S, additional, Grøfte, Thorbjørn, additional, Kirkegaard, Hans, additional, and Løfgren, Bo, additional

Published
2015
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37. Abstract 16179: A Novel Protocol for Dispatcher Assisted Cardiopulmonary Resuscitation Improves Quality of Cardiopulmonary Resuscitation: A Randomized Controlled Simulation Study

Author

Rasmussen, Stinne E, primary, Nebsbjerg, Mette A, additional, Bjørnshave, Katrine, additional, Krogh, Lise Q, additional, Krogh, Kristian, additional, Povlsen, Jonas A, additional, Riddervold, Ingunn S, additional, Grøfte, Thorbjørn, additional, Kirkegaard, Hans, additional, and Løfgren, Bo, additional

Published
2015
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44. Prehospital triage of patients suffering severe dyspnoea using N-terminal pro-brain natriuretic peptide, the PreBNP trial: a randomised controlled clinical trial

Author

Bøtker, Morten T, Jørgensen, Maren T, Stengaard, Carsten, Seidenfaden, Sophie-Charlott, Tarpgaard, Mona, Granfeldt, Asger, Mortensen, Tanja Ø, Grøfte, Thorbjørn, Friesgaard, Kristian D, Mærkedahl, Rikke, Pedersen, Anette B, Lundorff, Simon, Hansen, Troels Martin, Kirkegaard, Hans, Christensen, Erika F, and Terkelsen, Christian J

Abstract

Purpose: The purpose of this study was to examine whether the addition of brain natriuretic peptide measurement to the routine diagnostic work-up by prehospital critical care team physicians improves triage in patients with severe dyspnoea.Methods: Prehospital critical care team physicians randomly assigned patients older than 18 years with severe dyspnoea to routine diagnostic work-up or diagnostic work-up with incorporated point-of-care N-terminal pro-brain natriuretic peptide (NT-proBNP) measurement. The primary endpoint was the proportion of patients with dyspnoea of primary cardiac origin triaged directly to a department of cardiology.Results: A total of 747 patients were randomly assigned and 711 patients consented to participate, 350 were randomly assigned to the NT-proBNP group and 361 to the routine work-up group. NT-proBNP was measured in 90% (315/350) of patients in the NT-proBNP group and in 19% (70/361) of patients in the routine work-up group. There was no difference in the proportion of patients with dyspnoea of primary cardiac origin triaged directly to a department of cardiology between the NT-proBNP group and the routine work-up group (75% vs. 69%, P=0.22) in the intention-to-treat analysis. Sensitivity analysis according to the de facto diagnostics performed showed results consistent with this. No differences in hospital length of stay, intensive care unit admission rates or mortality between the NT-proBNP group and the routine work-up group were observed.Conclusion: Routine supplementary point-of-care measurement of NT-proBNP in patients with severe dyspnoea did not improve triage of patients with dyspnoea primarily caused by heart disease. ClinicalTrials.govidentifier NCT02050282.

Published
2018
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