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Acute myocardial infarction is associated with high mortality rates and poor long term prognosis. Due to the post-mitotic state of cardiomyocytes, the heart remodels in response to injury and cardiac function is impaired. In this study we demonstrate, that in a porcine ischemia reperfusion model a single injection of recombinant human agrin into the coronary artery ameliorates hallmarks of adverse cardiac remodeling and preserves global cardiac function via a pleiotropic mechanism of action., Der akute Myokardinfarkt geht mit hoher Sterblichkeitsrate und schlechter Langzeitprognose einher. Da Kardiomyozyten post-mitotisch sind, führen Umbauprozesse im Herzen nach Myokardschädigung zu einer eingeschränkten Herzfunktion. Diese Studie legt anhand eines porzinen Ischämie-Reperfusions-Modells dar, dass eine einzelne Injektion von rekombinanten humanen Agrin über einen pleiotropen Wirkmechanismus Kennzeichen kardialer Umbauprozesse verbessert und die Herzfunktion aufrechterhält.

The European Cooperation in Science and Technology (COST) is an intergovernmental organization dedicated to funding and coordinating scientific and technological research in Europe, fostering collaboration among researchers and institutions across countries. Recently, COST Action funded the “Genome Editing to treat Human Diseases” (GenE-HumDi) network, uniting various stakeholders such as pharmaceutical companies, academic institutions, regulatory agencies, biotech firms, and patient advocacy groups. GenE-HumDi's primary objective is to expedite the application of genome editing for therapeutic purposes in treating human diseases. To achieve this goal, GenE-HumDi is organized in several working groups, each focusing on specific aspects. These groups aim to enhance genome editing technologies, assess delivery systems, address safety concerns, promote clinical translation, and develop regulatory guidelines. The network seeks to establish standard procedures and guidelines for these areas to standardize scientific practices and facilitate knowledge sharing. Furthermore, GenE-HumDi aims to communicate its findings to the public in accessible yet rigorous language, emphasizing genome editing's potential to revolutionize the treatment of many human diseases. The inaugural GenE-HumDi meeting, held in Granada, Spain, in March 2023, featured presentations from experts in the field, discussing recent breakthroughs in delivery methods, safety measures, clinical translation, and regulatory aspects related to gene editing.