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1,046 results on '"Graaf, Winette T."'

1. Evaluating the Clinical Impact and Feasibility of Therapeutic Drug Monitoring of Pazopanib in a Real-World Soft-Tissue Sarcoma Cohort

Author

Meertens, Marinda, Giraud, Eline L., van der Kleij, Maud B. A., Westerdijk, Kim, Guchelaar, Niels A. D., Bleckman, Roos F., Rieborn, Amy, Imholz, Alex L. T, Otten, Hans-Martin, Vulink, Annelie, Los, Maartje, Hamberg, Paul, van der Graaf, Winette T. A., Gelderblom, Hans, Moes, Dirk Jan A. R., Broekman, K. Esther, Touw, Daan J., Koolen, Stijn L. W., Mathijssen, Ron H. J., Huitema, Alwin D. R., van Erp, Nielka P., Desar, Ingrid M. E., and Steeghs, Neeltje

Published
2024
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3. Pre-treatment fertility preservation and post-treatment reproduction in long-term survivors of adolescent and young adult (AYA) cancer

Author

Lehmann, Vicky, Vlooswijk, Carla, van der Graaf, Winette T. A., Bijlsma, Rhodé, Kaal, Suzanne E. J., Kerst, Jan Martijn, Tromp, Jacqueline M., Bos, Monique E. M. M., van der Hulle, Tom, Lalisang, Roy I., Nuver, Janine, Kouwenhoven, Mathilde C. M., Lok, Christianne A. R., Beerendonk, Catharina C. M., Dinkelman-Smit, Marij, and Husson, Olga

Published
2024
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4. Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations for cancer prevention in adolescent and young adult (AYA) cancer survivors: results from the SURVAYA study

Author

Gavioli, Costanza, Vlooswijk, Carla, Janssen, Silvie H. M., Kaal, Suzanne E. J., Kerst, J. Martijn, Tromp, Jacqueline M., Bos, Monique E. M. M., van der Hulle, Tom, van der Graaf, Winette T. A., Lalisang, Roy I., Nuver, Janine, Bijlsma, Rhodé M., Kouwenhoven, Mathilde C. M., Husson, Olga, and Beijer, Sandra

Published
2024
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5. Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GISTs) is Effective and Safe: Results from a Prospective Single-Center Study with 108 Patients

Author

van der Burg, Stijn J. C., van de Wal, Deborah, Roets, Evelyne, Steeghs, Neeltje, van Sandick, Johanna W., Kerst, Martijn, van Coevorden, Frits, Hartemink, Koen J., Veenhof, Xander A. A. F. A., Koenen, Anne Miek, Ijzerman, Nikki, van der Graaf, Winette T. A., Schrage, Yvonne M., and van Houdt, Winan J.

Published
2023
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7. Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors

Author

Gounder, Mrinal, Ratan, Ravin, Alcindor, Thierry, Schöffski, Patrick, van der Graaf, Winette T, Wilky, Breelyn A, Riedel, Richard F, Lim, Allison, Smith, L Mary, Moody, Stephanie, Attia, Steven, Chawla, Sant, D’Amato, Gina, Federman, Noah, Merriam, Priscilla, Van Tine, Brian A, Vincenzi, Bruno, Benson, Charlotte, Bui, Nam Quoc, Chugh, Rashmi, Tinoco, Gabriel, Charlson, John, Dileo, Palma, Hartner, Lee, Lapeire, Lore, Mazzeo, Filomena, Palmerini, Emanuela, Reichardt, Peter, Stacchiotti, Silvia, Bailey, Howard H, Burgess, Melissa A, Cote, Gregory M, Davis, Lara E, Deshpande, Hari, Gelderblom, Hans, Grignani, Giovanni, Loggers, Elizabeth, Philip, Tony, Pressey, Joseph G, Kummar, Shivaani, and Kasper, Bernd

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Aging, Pain Research, Clinical Trials and Supportive Activities, Patient Safety, Women's Health, Clinical Research, Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Female, Humans, Amyloid Precursor Protein Secretases, Antineoplastic Agents, Double-Blind Method, Fibromatosis, Aggressive, Gamma Secretase Inhibitors and Modulators, Progression-Free Survival, Quality of Life, Tetrahydronaphthalenes, Valine, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundDesmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments.MethodsWe conducted a phase 3, international, double-blind, randomized, placebo-controlled trial of nirogacestat in adults with progressing desmoid tumors according to the Response Evaluation Criteria in Solid Tumors, version 1.1. Patients were assigned in a 1:1 ratio to receive the oral γ-secretase inhibitor nirogacestat (150 mg) or placebo twice daily. The primary end point was progression-free survival.ResultsFrom May 2019 through August 2020, a total of 70 patients were assigned to receive nirogacestat and 72 to receive placebo. Nirogacestat had a significant progression-free survival benefit over placebo (hazard ratio for disease progression or death, 0.29; 95% confidence interval, 0.15 to 0.55; P

Published
2023

8. Health-related quality of life of Adolescent and Young Adult Cancer Survivors before and during the COVID-19 pandemic: longitudinal improvements on social functioning and fatigue

Author

Vlooswijk, Carla, Janssen, Silvie H. M., van de Poll-Franse, Lonneke V., Bijlsma, Rhodé, Kaal, Suzanne E. J., Kerst, J. Martijn, Tromp, Jacqueline M., Bos, Monique E. M. M., Lalisang, Roy I., Nuver, Janine, Kouwenhoven, Mathilde C. M., van der Graaf, Winette T. A., and Husson, Olga

Published
2023
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12. Molecular imaging predicts lack of T-DM1 response in advanced HER2-positive breast cancer (final results of ZEPHIR trial)

Author

Mileva, Magdalena, de Vries, Elisabeth G. E., Guiot, Thomas, Wimana, Zéna, Deleu, Anne-Leen, Schröder, Carolien P., Lefebvre, Yolene, Paesmans, Marianne, Stroobants, Sigrid, Huizing, Manon, Aftimos, Philippe, Tol, Jolien, Van der Graaf, Winette T. A., Oyen, Wim J. G., Vugts, Danielle J., Menke-van der Houven van Oordt, C. Willemien, Brouwers, Adrienne H., Piccart-Gebhart, Martine, Flamen, Patrick, and Gebhart, Géraldine

Published
2024
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13. Defining the role of real-world data in cancer clinical research: The position of the European Organisation for Research and Treatment of Cancer

Author

Saesen, Robbe, Van Hemelrijck, Mieke, Bogaerts, Jan, Booth, Christopher M., Cornelissen, Jan J., Dekker, Andre, Eisenhauer, Elizabeth A., Freitas, André, Gronchi, Alessandro, Hernán, Miguel A., Hulstaert, Frank, Ost, Piet, Szturz, Petr, Verkooijen, Helena M., Weller, Michael, Wilson, Roger, Lacombe, Denis, and van der Graaf, Winette T.

Published
2023
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17. ASO Visual Abstract: Prognosis of Patients with Cutaneous Angiosarcoma After Surgical Resection with Curative Intent—Is There a Difference Between the Subtypes?

Author

Reijers, Sophie J. M., Huis in’t Veld, Eva A., Grünhagen, Dirk J., Smith, Myles J. F., van Ginhoven, Tessa M., van Coevorden, Frits, van der Graaf, Winette T. A., Schrage, Yvonne, Strauss, Dirk C., Haas, Rick L. M., Verhoef, Cornelis J., Hayes, Andrew J., and van Houdt, Winan J.

Published
2023
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19. Employment outcomes of adolescent and young adult cancer survivors and their partners: A Dutch population‐based study.

Author

Dankers, Polle W., Janssen, Silvie H. M., van Eenbergen, Mies, Siflinger, Bettina M., van der Graaf, Winette T. A., and Husson, Olga

Subjects
YOUNG adults, CANCER patients, CANCER survivors, EMPLOYMENT statistics, VICTIMS, CENTRAL nervous system tumors, TEENAGERS
Abstract

Background: The aim of this population‐based registry study was to examine the impact of cancer on employment outcomes in adolescent and young adult (AYA) survivors and their partners and associated sociodemographic and clinical characteristics. Methods: A total of 2456 AYA cancer patients, diagnosed in 2013 and aged 18 through 39 years old, were selected from the Netherlands Cancer Registry and linked to employment data from Statistics Netherlands, from which 1252 partners of AYAs could be identified. For both patients and their partners, a control group with same age, migration background, and sex was selected. The impact (i.e., causal effect) was estimated by implementing a doubly robust difference‐in‐differences method, from 3 years before to 5 years after cancer diagnosis. Results: Patients suffered a reduced employment probability (3.8 percentage points) and number of hours worked when employed (3.8%). This effect was larger for females, and individuals with a migration background, high tumor stage, or diagnosed with a central nervous system tumor/hematologic malignancy. In regard to employment, no significant effect could be found for the patients' partners, although a 5.5 percentage‐point increase in employment probability was found in partners who were either unemployed or worked fewer than 400 hours. Conclusions: A cancer diagnosis significantly affects employment outcomes of AYA patients with cancer. Patients at risk should have access to services such as job counseling to help them return into society in the best possible way. No objective impact on partners' employment outcomes was found; however, subjective well‐being was not taken into account. Plain Language Summary: This study estimated the causal effect of a cancer diagnosis on employment outcomes.Adolescent and young adult cancer survivors face a reduction in both employment probability and the number of hours worked when employed.Partners that were unemployed or worked the least number of hours a year before diagnosis had a 5.5 percentage‐point increased employment probability, but for other partners effects are small. This population‐based registry study provides insight in the impact of cancer on employment outcomes in adolescent and young adult (AYA) cancer survivors and their partners until 5 years after diagnosis. AYA cancer survivors and partners at risk should have access to services to help them return into society in the best way possible. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Patient-Reported Outcomes of Accelerated Aging: A Novel Approach to Investigate Second Cancer Risk in Adolescent and Young Adult (18−39 Years) Cancer Survivors.

Author

Meer, Daniël J van der, Zevenbergen, Susan, Vlooswijk, Carla, Bijlsma, Rhodé M, Kaal, Suzanne E J, Kerst, Jan Martijn, Tromp, Jacqueline M, Bos, Monique E M M, van der Hulle, Tom, Lalisang, Roy I, Nuver, Janine, Kouwenhoven, Mathilde C M, Graaf, Winette T A van der, and Husson, Olga

Subjects
TUMOR treatment, SELF-evaluation, RESEARCH funding, CANCER patients, DESCRIPTIVE statistics, SLEEP duration, AGING, EXERCISE tolerance, HEALTH outcome assessment, SOCIODEMOGRAPHIC factors, DATA analysis software, CONFIDENCE intervals, SECONDARY primary cancer, DISEASE complications
Abstract

Background Adolescent and young adult cancer survivors (AYAs, aged 18-39 years at first diagnosis) have a higher second cancer risk. Accelerated aging is hypothesized as underlying mechanism and has been described clinically by 6 indicators; fatigue, low quality of sleep, low mood, lack of motivation, subjective memory complaints, and poor exercise tolerance. Using patient-reported outcomes, we aimed to identify clusters of accelerated aging among AYA cancer survivors and to investigate their association with second cancer development. Patients and Methods Patient, tumor, and treatment data were obtained from the Netherlands Cancer Registry. Patient-reported clinical indicators and second cancer data were obtained from the SURVivors (5-20 years) of cancer in AYAs (SURVAYA) questionnaire study between 1999 and 2015. Latent class and multivariable logistic regression analyses were performed. Results In total, n  = 3734 AYA survivors with known second cancer status (n  = 278 [7.4%] second cancers) were included. Four latent clusters were identified and named based on their clinical indicator features; (1) high accelerated aging (31.3%), (2) intermediate accelerated aging without poor exercise tolerance (15.1%), (3) intermediate accelerated aging without lack of motivation (27.4%), and (4) low accelerated aging (26.2%). AYAs in the high accelerated aging cluster were more likely to have second cancer (odds ratio: 1.6; 95% CI, 1.1-2.3) compared to the low accelerated aging cluster. Conclusion AYAs with a higher burden of accelerated aging were more likely to develop a second cancer. Validation of the clinical indicators and how to best capture them is needed to improve (early) detection of AYAs at high risk of developing second cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Patient-Reported Outcomes of Accelerated Aging: A Novel Approach to Investigate Second Cancer Risk in Adolescent and Young Adult (18−39 Years) Cancer Survivors

Author

van der Meer, Daniël J, primary, Zevenbergen, Susan, additional, Vlooswijk, Carla, additional, Bijlsma, Rhodé M, additional, Kaal, Suzanne E J, additional, Kerst, Jan Martijn, additional, Tromp, Jacqueline M, additional, Bos, Monique E M M, additional, van der Hulle, Tom, additional, Lalisang, Roy I, additional, Nuver, Janine, additional, Kouwenhoven, Mathilde C M, additional, van der Graaf, Winette T A, additional, and Husson, Olga, additional

Published
2023
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25. Financial difficulties experienced by patients with gastrointestinal stromal tumours (GIST) in the Netherlands: data from a cross-sectional multicenter study

Author

de Wal, Deborah van, primary, Hollander, Dide den, additional, Desar, Ingrid M. E., additional, Gelderblom, Hans, additional, Oosten, Astrid W., additional, Reyners, Anna K. L., additional, Steeghs, Neeltje, additional, Husson, Olga, additional, and Graaf, Winette T. A. van der, additional

Published
2023
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26. The association of having a monitoring or blunting coping style with psychological distress, health-related quality of life and satisfaction with healthcare in gastrointestinal stromal tumour (GIST) patients

Author

van de Wal, Deborah, primary, van Doorn, Britt, additional, den Hollander, Dide, additional, Desar, Ingrid M. E., additional, Gelderblom, Hans, additional, Oosten, Astrid W., additional, Reyners, Anna K. L., additional, Steeghs, Neeltje, additional, van der Graaf, Winette T. A., additional, and Husson, Olga, additional

Published
2023
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29. Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial

Author

Boudewijns, Steve, Bloemendal, Martine, de Haas, Nienke, Westdorp, Harm, Bol, Kalijn F., Schreibelt, Gerty, Aarntzen, Erik H. J. G., Lesterhuis, W. Joost, Gorris, Mark A. J., Croockewit, Alexandra, van der Woude, Lieke L., van Rossum, Michelle M., Welzen, Marieke, de Goede, Anna, Hato, Stanleyson V., van der Graaf, Winette T. A., Punt, Cornelis J. A., Koornstra, Rutger H. T., Gerritsen, Winald R., Figdor, Carl G., and de Vries, I. Jolanda M.

Published
2020
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33. Same Journey, Different Paths: Caregiver Burden among Informal Caregivers of Adolescent and Young Adult Patients with an Uncertain or Poor Cancer Prognosis (UPCP).

Author

Reuvers, Milou J. P., Burgers, Vivian W. G., Vlooswijk, Carla, Verhees, Bram, Husson, Olga, and van der Graaf, Winette T. A.

Subjects
CAREGIVERS, BURDEN of care, YOUNG adults, CANCER prognosis, FAMILIES
Abstract

A minority of adolescent and young adult cancer patients (AYA) live with an uncertain or poor prognosis (UPCP). Caring for a young, advanced cancer patient can lead to caregiver burden. This study aims to provide insight into burden on informal caregivers of AYA cancer patients with UPCP. In-depth, semistructured interviews were conducted with parents (n = 12), siblings (n = 7), friends (n = 7), and partners (n = 13). Thematic analysis was performed to derive themes from the data. Participants reported sleeping problems and stress. They struggle with uncertainty, fear, loss, and negative emotions. Family life is altered due to solely taking care of the children, but also the AYA. Contact with friends and family is changed. The relationship to the AYA can shift positively (e.g., becoming closer) or negatively (e.g., more conflict or no longer being attracted). Participants were under pressure, having to take on many responsibilities and multiple roles. In the financial domain, they report less income and often must continue working. A high amount of caregiver burden is experienced among informal caregivers of AYAs with UPCP. Yet only part of the impact appears to be age specific. Specific, age-adjusted interventions can be developed to lower the burden. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma

Author

Verhoeff, Sarah R., van Es, Suzanne C., Boon, Eline, van Helden, Erik, Angus, Lindsay, Elias, Sjoerd G., Oosting, Sjoukje F., Aarntzen, Erik H., Brouwers, Adrienne H., Kwee, Thomas C., Heskamp, Sandra, Hoekstra, Otto S., Verheul, Henk, van der Veldt, Astrid A. M., de Vries, Elisabeth G. E., Boerman, Otto C., van der Graaf, Winette T. A., Oyen, Wim J. G., and van Herpen, Carla M. L.

Published
2019
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40. Physical symptom burden in patients with desmoid‐type fibromatosis and its impact on health‐related quality of life and healthcare use

Author

Schut, Anne‐Rose W., primary, de Bruin, Leanne E., additional, de Rooij, Belle H., additional, Lidington, Emma, additional, Timbergen, Milea J. M., additional, van der Graaf, Winette T. A., additional, van Houdt, Winan J., additional, Bonenkamp, Johannes J., additional, Jones, Robin L., additional, Grünhagen, Dirk. J., additional, Sleijfer, Stefan, additional, Gennatas, Spyridon, additional, Verhoef, Cornelis, additional, and Husson, Olga, additional

Published
2023
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41. Learning from long‐term adolescent and young adult ( AYA ) cancer survivors regarding their age‐specific care needs to improve current AYA care programs

Author

Janssen, Silvie H. M., primary, Vlooswijk, Carla, additional, Manten‐Horst, Eveliene, additional, Sleeman, Sophia H. E., additional, Bijlsma, Rhodé M., additional, Kaal, Suzanne E. J., additional, Kerst, Jan Martijn, additional, Tromp, Jacqueline M., additional, Bos, Monique E. M. M., additional, van der Hulle, Tom, additional, Lalisang, Roy I., additional, Nuver, Janine, additional, Kouwenhoven, Mathilde C. M., additional, van der Graaf, Winette T. A., additional, and Husson, Olga, additional

Published
2023
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42. Supplementary Data from Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials

Author

Mir, Olivier, primary, Touati, Nathan, primary, Lia, Michela, primary, Litière, Saskia, primary, Le Cesne, Axel, primary, Sleijfer, Stefan, primary, Blay, Jean-Yves, primary, Leahy, Michael, primary, Young, Robin, primary, Mathijssen, Ron H.J., primary, Van Erp, Nielka P., primary, Gelderblom, Hans, primary, Van der Graaf, Winette T., primary, and Gronchi, Alessandro, primary

Published
2023
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45. Therapeutic drug monitoring to personalize dosing of imatinib, sunitinib, and pazopanib: A mixed methods study on barriers and facilitators.

Author

Westerdijk, Kim, Steeghs, Neeltje, Tacke, Casper S. J., van der Graaf, Winette T. A., van Erp, Nielka P., van Oortmerssen, Gerard, Hermens, Rosella P. M. G., and Desar, Ingrid M. E.

Subjects
DRUG monitoring, SUNITINIB, HEALTH insurance companies, IMATINIB, MEDICAL personnel
Abstract

Background: Personalized dosing based on measurement of individual drug levels and adjusting the dose accordingly can improve efficacy and decrease unnecessary toxicity of oncological treatment. For imatinib, sunitinib, and pazopanib, this therapeutic drug monitoring (TDM)‐guided dosing is, however, not routinely used, despite accumulating evidence favoring individualized dosing. Therefore, we aimed to identify and quantify (potential) barriers and facilitators in TDM‐guided dosing for imatinib, sunitinib, and pazopanib. Methods: We performed a mixed methods study among all stakeholders involved: patients, healthcare professionals (HCPs), pharmaceutical companies, and health insurance companies. During the first qualitative part of this study, we performed semi‐structured individual interviews and one focus group interview to identify all (potential) barriers and facilitators, and during the second quantitative part of this study, we used a web‐based survey to quantify these findings. The interviews addressed the six domains of the implementation of change model of Grol and Wensing: (1) the innovation itself; (2) the HCP; (3) the patient; (4) social context; (5) organizational context; and (6) finances, law, and governance. Results: In the qualitative study, we interviewed 20 patients, 18 HCPs and 10 representatives of pharmaceutical and health insurance companies and identified 72 barriers and 90 facilitators. In the quantitative study, the survey was responded by 66 HCPs and 58 patients. Important barriers were on the domain of the HCP, such as a lack of experience with TDM (36.4%), on the domain of the patient, such as lack of awareness of TDM (39.7%), and the processing time for measurement and interpretation of the TDM result (40.9%) (organizational domain). Important facilitators were education of HCPs (95.5%), education of patients (87.9%) and facilitating an overview of when and where TDM measurements are being performed (86.4%). Conclusion: We identified and quantified important barriers and facilitators for the implementation of TDM‐guided dosing for imatinib, sunitinib, and pazopanib. Based on our results, the implementation strategy should mainly focus on educating both HCPs and patients and on the organizational aspect of TDM. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia

Author

Hurkmans, Evelien G. E., primary, Klumpers, Marije J., additional, Dello Russo, Cinzia, additional, De Witte, Ward, additional, Guchelaar, Henk-Jan, additional, Gelderblom, Hans, additional, Cleton-Jansen, Anne-Marie, additional, Vermeulen, Sita H., additional, Kaal, Suzanne, additional, van der Graaf, Winette T. A., additional, Flucke, Uta, additional, Gidding, Corrie E. M., additional, Schreuder, Hendrik W. B., additional, de Bont, Eveline S. J. M., additional, Caron, Huib N., additional, Gattuso, Giovanna, additional, Schiavello, Elisabetta, additional, Terenziani, Monica, additional, Massimino, Maura, additional, McCowage, Geoff, additional, Nagabushan, Sumanth, additional, Limaye, Anuja, additional, Rose, Victoria, additional, Catchpoole, Daniel, additional, Jorgensen, Andrea L., additional, Barton, Christopher, additional, Delaney, Lucy, additional, Hawcutt, Daniel B., additional, Pirmohamed, Munir, additional, Pizer, Barry, additional, Coenen, Marieke J. H., additional, and te Loo, D. Maroeska W. M., additional

Published
2023
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