39 results on '"Graciano, Ana Lia"'
Search Results
2. 107: CURRENT LANDSCAPE OF ADVANCED PRACTICE PROVIDERS IN CRITICAL CARE
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Butcher, Amy, primary, Sandor, Peter, additional, Graciano, Ana Lia, additional, Lizano, Danny, additional, Samanta, Damayanti, additional, Akuamoah-Boateng, Kwame, additional, Avadhani, Amita, additional, and Newman, Christopher, additional
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- 2022
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3. 108: INFLUENCE OF COVID-19 ON BURNOUT AMONG CRITICAL CARE ADVANCED PRACTICE PROVIDERS
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Avadhani, Amita, primary, Akuamoah-Boateng, Kwame, additional, Lizano, Danny, additional, Sandor, Peter, additional, Westwick-Butcher, Amy, additional, Newman, Christopher, additional, Samanta, Damayanti, additional, and Graciano, Ana Lia, additional
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- 2022
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4. 537: BILATERAL CEREBRAL STROKES AND ADRENAL HEMORRHAGE ASSOCIATED WITH MIS-A
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Kandeepan, Aarani, primary, Holloway, Adrian, additional, and Graciano, Ana Lia, additional
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- 2022
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5. Chlorpromazine as Treatment for Refractory Agitation Associated with Pediatric Delirium
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Kim, Shin Young, primary, Simone, Shari, additional, Kishk, Omayma A., additional, Graciano, Ana Lia, additional, Seung, Hyunuk, additional, and Edwards, Sarah, additional
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- 2022
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6. Developmental Cardiac Physiology
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Kocis, Keith C., Graciano, Ana Lia., and Meliones, Jon N.
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- 2009
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7. Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs
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Li, Simon, Hsieh, Ting-Chang, Rehder, Kyle J., Nett, Sholeen, Kamat, Pradip, Napolitano, Natalie, Turner, David A., Adu-Darko, Michelle, Jarvis, J. Dean, Krawiec, Conrad, Derbyshire, Ashley T., Meyer, Keith, Giuliano, John S., Jr, Tala, Joana, Tarquinio, Keiko, Ruppe, Michael D., Sanders, Ronald C., Jr, Pinto, Matthew, Howell, Joy D., Parker, Margaret M., Nuthall, Gabrielle, Shepherd, Michael, Emeriaud, Guillaume, Nagai, Yuki, Saito, Osamu, Lee, Jan Hau, Simon, Dennis W., Orioles, Alberto, Walson, Karen, Vanderford, Paula, Shenoi, Asha, Lee, Anthony, Bird, Geoffrey L., Miksa, Michael, Graciano, Ana Lia, Bain, Jesse, Skippen, Peter W, Polikoff, Lee A., Nadkarni, Vinay, and Nishisaki, Akira
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- 2018
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8. The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary
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Davis, Alan L., Carcillo, Joseph A., Aneja, Rajesh K., Deymann, Andreas J., Lin, John C., Nguyen, Trung C., Okhuysen-Cawley, Regina S., Relvas, Monica S., Rozenfeld, Ranna A., Skippen, Peter W., Stojadinovic, Bonnie J., Williams, Eric A., Yeh, Tim S., Balamuth, Fran, Brierley, Joe, de Caen, Allan R., Cheifetz, Ira M., Choong, Karen, Conway, Edward, Jr, Cornell, Timothy, Doctor, Allan, Dugas, Marc-Andre, Feldman, Jonathan D., Fitzgerald, Julie C., Flori, Heidi R., Fortenberry, James D., Graciano, Ana Lia, Greenwald, Bruce M., Hall, Mark W., Han, Yong Yun, Hernan, Lynn J., Irazuzta, Jose E., Iselin, Elizabeth, van der Jagt, Elise W., Jeffries, Howard E., Kache, Saraswati, Katyal, Chhavi, Kissoon, Niranjan, Kon, Alexander A., Kutko, Martha C., MacLaren, Graeme, Maul, Timothy, Mehta, Renuka, Odetola, Fola, Parbuoni, Kristine, Paul, Raina, Peters, Mark J., Ranjit, Suchitra, Reuter-Rice, Karin E., Schnitzler, Eduardo J., Scott, Halden F., Torres, Adalberto, Jr, Weingarten-Abrams, Jacki, Weiss, Scott L., Zimmerman, Jerry J., and Zuckerberg, Aaron L.
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- 2017
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9. 28 - Cardiac failure and ventricular assist devices
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Graciano, Ana Lia, Philip, Joseph, and Kocis, Keith C.
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- 2022
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10. Incidence and associated factors of difficult tracheal intubations in pediatric ICUs: a report from National Emergency Airway Registry for Children: NEAR4KIDS
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Graciano, Ana Lia, Tamburro, Robert, Thompson, Ann E., Fiadjoe, John, Nadkarni, Vinay M., and Nishisaki, Akira
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- 2014
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11. Chlorpromazine as Treatment for Refractory Agitation Associated with Pediatric Delirium.
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Shin Young Kim, Simone, Shari, Kishk, Omayma A., Graciano, Ana Lia, Hyunuk Seung, and Edwards, Sarah
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CHLORPROMAZINE ,CRITICALLY ill children ,ARIPIPRAZOLE ,DELIRIUM ,PEDIATRIC intensive care ,INTENSIVE care units - Abstract
OBJECTIVE Delirium and agitation can be devastating and prolong the length of hospitalization. As part of our continuous improvement efforts, we implemented the use of intermittent chlorpromazine therapy to target refractory agitation associated with hyperactive or mixed delirium (RAA-D). The purpose of this study was to evaluate the effectiveness of chlorpromazine on RAA-D and delirium symptoms as well as any adverse effects in critically ill children. METHODS Retrospective chart review was conducted for children admitted to the pediatric intensive care unit who were treated with chlorpromazine for RAA-D from March 2017 to January 2019. The primary end point was to determine differences in Cornell Assessment for Pediatric Delirium (CAPD) and State Behavioral Scale (SBS) scores 24 hours before and after chlorpromazine administration. The secondary end points were the 24-hour cumulative dosing of narcotic and sedative agents before and after chlorpromazine administration and adverse events associated with chlorpromazine use. RESULTS Twenty-six patients were treated with chlorpromazine for RAA-D; 16 (61.5%) were male with a median age of 14.5 months (IQR, 6-48). The mean CAPD (n = 24) and median SBS (n = 23) scores were significantly lower 24 hours after chlorpromazine use when compared to baseline scores, 12 vs 8.9 (p = 0.0021) and 1 vs -1, (p = 0.0005) respectively. No significant adverse effects were observed. CONCLUSIONS Chlorpromazine use in critically ill children with RAA-D was helpful for managing symptoms without adverse events. Further investigation is needed to evaluate the use of chlorpromazine to treat RAA-D to avoid long-term use of an antipsychotic. ABBREVIATIONS CAPD, Cornell Assessment for Pediatric Delirium; EPS, extrapyramidal symptoms; FDA, US Food and Drug Administration; ICU, intensive care unit; IV, intravenous; LOS, length of stay; MV, mechanical ventilation; PICU, pediatric intensive care unit; PIM, Pediatric Index of Mortality; RAA-D, refractory agitation associated with hyperactive or mixed delirium; SBS, State Behavioral Scale [ABSTRACT FROM AUTHOR]
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- 2022
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12. Developmental Cardiac Physiology
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Kocis, Keith C., primary, Graciano, Ana Lia., additional, and Meliones, Jon N., additional
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- 2008
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13. Reduction in paediatric intensive care admissions during COVID-19 lockdown in Maryland, USA
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Graciano, Ana Lia, primary, Bhutta, Adnan T, additional, and Custer, Jason W, additional
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- 2020
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14. Botulism in the Pediatric Intensive Care Units in the United States: Interrogating a National Database
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Howes, Cynthia, additional, Hiatt, Kerith, additional, Turlington, Katherine, additional, Foster, Cortney, additional, Holloway, Adrian, additional, Graciano, Ana Lia, additional, Custer, Jason, additional, Bhutta, Adnan, additional, and Bagdure, Dayanand, additional
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- 2019
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15. Antipsychotic Treatment of Delirium in Critically Ill Children: A Retrospective Matched Cohort Study
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Kishk, Omayma A., primary, Simone, Shari, additional, Lardieri, Allison B., additional, Graciano, Ana Lia, additional, Tumulty, Jamie, additional, and Edwards, Sarah, additional
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- 2019
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16. Contributors
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Abecassis, Isaac Josh, Abeysekera, Jayani, Adelson, P. David, Agbeko, Rachel S., Agus, Michael S.D., Ahmed, Mubbasheer, Akhondi-Asl, Alireza, Albert, Ben D., Alcamo, Alicia, Alder, Matthew N., Alibrahim, Omar, Allareddy, Veerajalandhar, Almodovar, Melvin C., Aminoff, Alexandra, Amlie-Lefond, Catherine, Aneja, Rajesh, Apple, Abigail, Argent, Andrew C., Arvedson, Joan C., Aspesberro, François, Atlas, Nir, Baatz, John E., Baden, Harris P., Bakar, Adnan M., Banker, Katherine, Barker, Piers C.A., Bass, Lee M., Basu, Rajit K., Bayir, Hülya, Becker, Lance B., Bell, Jamie L., Bell, Michael J., Bembea, Melania M., Bender, M.A., Benscoter, Alexis L., Benton, Wade W., Berg, Robert A., Berkman, Emily, Berkowitz, Carol, Biagas, Katherine V., Bishop, Naomi B., Blatt, Julie, Bodilly, Lauren, Bonow, Robert H., Bragg, E. Alexis, Brandom, Barbara W., Brilli, Richard J., Brogan, Thomas V., Bronicki, Ronald A., Browd, Samuel R., Bunchman, Timothy E., Burns, Jeffrey P., Butler, David F., Caglar, Derya, Camitta, Michael W., Campbell, M. Jay, Campbell, Sally, Capek, Karel D., Carboni, Michael P., Carcillo, Joseph A., Cassara, Antonio, Censoplano, Nina, Chadwick, Victoria, Chamberlain, Reid C., Chan, Anny, Charpie, John R., Cheifetz, Ira M., Chiwane, Saurabh, Chun, Robert H., Clark, Jeff, Clark, Jonna D., Clark, Robert S.B., Clawson, April, Clayton, Jason A., Conlon, Thomas, Conrad, Carol, Conway, Edward E., Jr, Coopersmith, Craig M., Corey, Seth J., Dahmer, Mary K., Dalton, Heidi J., Damania, Rahul C., Damian, Mihaela A., Dartois, Lauren, Davis, Peter J., Dervan, Leslie A., Deutschman, Clifford S., Dezfulian, Cameron, Dick, André A.S., Diekema, Douglas S., Dingeldein, Michael, Doctor, Allan, Downes, John J., Duncan, Christine, Edwards, Christopher M., Edwards, Lauren R., Egbuta, Chinyere, Eigen, Howard, Elfassy, Hannah Laure, Ellis, Alison M., Evans, Idris V.R., Farris, Reid W.D., Fineman, Jeffrey R., Fink, Ericka L., Fish, Frank A., Fitzgerald, Tamara N., Fleming, Gregory A., Flores, Saul, Flynn, Joseph T., Forbes, Michael L., Forbess, Joseph M., Franzon, Deborah E., Frazier, W. Joshua, Fuhrman, Bradley P., Ginther, Richard M., Jr, Glaser, Nicole, Graciano, Ana Lia, Gray, Megan M., Greathouse, Kristin C., Greenwald, Bruce M., Grinsell, Matthew M., Grunwell, Jocelyn R., Gunnarsson, Björn, Guzman, Marla, Hahn, Timothy, Hall, Mark W., Harding, Cary O., Hartman, Mary E., Hartmann, Silvia M., Havlin, Kevin M., Hayward, Kristen, Healey, Patrick J., Heard, Christopher M.B., Heneghan, Julia A., Herndon, David N., Hernan, Lynn J., Hill, Kevin D., Hoffman, Julien I., Holinski, Paula, Hong, Sue J., Horslen, Simon, Hoskote, Aparna, Hotz, Justin C., Ibsen, Laura Marie, Ijsselstijn, Hanneke, Jackson, Travis C., Jamal, Shelina M., Joshi, Prashant, Joyce, Emily L., Kallay, Tom, Kamat, Pradip P., Kane, Jason M., Kannankeril, Prince J., Karam, Oliver, Kenningham, Katherine L., Khalatbari, Hedieh, Khemani, Robinder G., Killien, Elizabeth Y., Kim, Yun, Kingsley, Jenny, Kirk, Christa Jefferis, Kirmani, Sonya, Kleinpell, Ruth, Kochanek, Patrick M., Kocis, Keith C., Kocoshis, Samuel A., Koves, Ildiko H., Kudchadkar, Sapna R., Kulik, Thomas J., Lacroix, Jacques, Lebet, Ruth, Lee, Amy, Lenker, Hallie, Levin, Daniel L., Levy, Emily R., Lewis-Newby, Mithya, Lin, John C., Maddux, Aline, Malone, Matthew P., Manole, Mioara, Marsh, Anne, Martin, Richard J., Mathur, Mudit, McArthur, Jennifer, McCusker, Christine, McDonald, Ruth A., Mehta, Nilesh M., Melvin, Ann J., Menon, Shina, Monagle, Paul, Morgan, Ryan W., Morgenstern, Peter F., Morowitz, Michael J., Morrison, Wynne, Munshi, Raj, Muszynski, Jennifer A., Nadkarni, Vinay M., Naiditch, Jessica A., Nakagawa, Thomas A., Nguyen, Vu, Nickless, Jenna R., Nishisaki, Akira, Norwood, Victoria F., Notterman, Daniel A., Oishi, Peter, Ojemann, Jeffrey, Olson, Michelle L., O’Neal, Jessie, Orloff, Kirsten, Otteson, Todd, Ouellette, Yves, Parakininkas, Daiva, Parker, Robert I., Peeler, Katherine Ratzen, Perez, Francisco A., Perry, Melvin G., Jr, Peters, Mark J., Pfeiffer, Brent J., Phelan, Rachel, Philip, Joseph, Pinto, Neethi, Pollack, Murray M., Preston, Thomas J., Prodhan, Parthak, Quang, Lawrence, Quasney, Michael W., Raffay, Thomas M., Rajapreyar, Prakadeshwari, Rakes, Lauren, Ramos-Jimenez, Rafael G., Ray, Samiran, Reed, Christopher R., Reese, James J., Jr, Rehder, Kyle J., Remy, Kenneth E., Reyes, Jorge D., Rhee, Eileen, Richardson, Clare, Roberts, Joan S., Guerineau, Luciana Rodriguez, Rogers, Stephen, Rotta, Alexandre T., Rowin, Mark E., Ruppel, Randall, Ryan, Rita M., Said, Ahmed, Sallee, Colin J., Sandler, Britt Julia, Sankar, Jhuma, Sarnaik, Ajit A., Sarnaik, Ashok P., Sawin, Robert, Schenkman, Kenneth A., Schexnayder, Stephen M., Schleien, Charles L., Schwartz, Stephanie P., Schwartz, Steven M., Shah, Jay, Shah, Sareen, Shaw, Dennis W.W., Shein, Steven L., Shoykhet, Michael, Simon, Dennis W., Sivarajan, V. Ben, Slain, Katherine N., Smith, Jodi M., Smith, Lincoln S., Sochet, Anthony A., Sorce, Lauren R., Sousse, Linda E., Spaeder, Michael C., Speicher, Richard H., Spinella, Philip C., Stalets, Erika L., Standage, Stephen Wade, Stark, Rebecca, Starr, Michelle C., Steinhorn, David M., Stenmark, Kurt R., Stewart, Claire A., Stollings, Lindsay M., Stulce, Casey, Su, Erik, Summers, Corinne, Sutton, Robert M., Symons, Jordan M., Sznycer-Taub, Nathaniel R., Tamburro, Robert T., Jr, Tapking, Christian, Tasker, Robert C., Tatum, Gregory H., Tilton, Ann H., Timlin, Matthew R., Tissieres, Pierre, Tobias, Joseph D., Toltzis, Philip, Topjian, Alexis A., Torgerson, Troy, Traube, Chani, Tucci, Marisa, Tuggle, David, Turi, Jennifer L., Turner, David A., Cleave, Alisa Van, van der Velden, Meredith G., Vogel, Adam M., Vohwinkel, Christine, Andre-von Arnim, Amelie von Saint, Vora, Surabhi B., Waghmare, Alpana, Wainwright, Mark S., Wallisch, Jessica S., Watson, R. Scott, Watt, Kevin, Weimer, Maria, Weiss, Scott L., Wenger, Jesse, Wheeler, Derek S., Wieczorek, Beth, Wilhelm, Michael, Wong, Hector R., Woods, Charles R., Jr, Woodward, George A. (Tony), Yang, Amy C., Yu, Heidi, Zane, Nicole R., Zerr, Danielle M., Zhang, Hui, Zheng, Hengqi (Betty), Zimmerman, Jerry J., Zimmerman, Kanecia, Zinter, Matt S., and Zuppa, Athena F.
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- 2022
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17. Chapter 30 - Myocardial Dysfunction, Extracorporeal Life Support, and Ventricular Assist Devices
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Graciano, Ana Lía, Joashi, Umesh, and Kocis, Keith C.
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- 2017
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18. Downward Trend in Pediatric Resident Laryngoscopy Participation in PICUs
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Gabrani, Aayush, primary, Kojima, Taiki, additional, Sanders, Ronald C., additional, Shenoi, Asha, additional, Montgomery, Vicki, additional, Parsons, Simon J., additional, Gangadharan, Sandeep, additional, Nett, Sholeen, additional, Napolitano, Natalie, additional, Tarquinio, Keiko, additional, Simon, Dennis W., additional, Lee, Anthony, additional, Emeriaud, Guillaume, additional, Adu-Darko, Michelle, additional, Giuliano, John S., additional, Meyer, Keith, additional, Graciano, Ana Lia, additional, Turner, David A., additional, Krawiec, Conrad, additional, Bakar, Adnan M., additional, Polikoff, Lee A., additional, Parker, Margaret, additional, Harwayne-Gidansky, Ilana, additional, Crulli, Benjamin, additional, Vanderford, Paula, additional, Breuer, Ryan K., additional, Gradidge, Eleanor, additional, Branca, Aline, additional, Grater-Welt, Lily B., additional, Tellez, David, additional, Wright, Lisa V., additional, Pinto, Matthew, additional, Nadkarni, Vinay, additional, and Nishisaki, Akira, additional
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- 2018
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19. Implementation of an ICU Bundle
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Simone, Shari, primary, Edwards, Sarah, additional, Lardieri, Allison, additional, Walker, L. Kyle, additional, Graciano, Ana Lia, additional, Kishk, Omayma A., additional, and Custer, Jason W., additional
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- 2017
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20. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock
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Davis, Alan L., primary, Carcillo, Joseph A., additional, Aneja, Rajesh K., additional, Deymann, Andreas J., additional, Lin, John C., additional, Nguyen, Trung C., additional, Okhuysen-Cawley, Regina S., additional, Relvas, Monica S., additional, Rozenfeld, Ranna A., additional, Skippen, Peter W., additional, Stojadinovic, Bonnie J., additional, Williams, Eric A., additional, Yeh, Tim S., additional, Balamuth, Fran, additional, Brierley, Joe, additional, de Caen, Allan R., additional, Cheifetz, Ira M., additional, Choong, Karen, additional, Conway, Edward, additional, Cornell, Timothy, additional, Doctor, Allan, additional, Dugas, Marc-Andre, additional, Feldman, Jonathan D., additional, Fitzgerald, Julie C., additional, Flori, Heidi R., additional, Fortenberry, James D., additional, Graciano, Ana Lia, additional, Greenwald, Bruce M., additional, Hall, Mark W., additional, Han, Yong Yun, additional, Hernan, Lynn J., additional, Irazuzta, Jose E., additional, Iselin, Elizabeth, additional, van der Jagt, Elise W., additional, Jeffries, Howard E., additional, Kache, Saraswati, additional, Katyal, Chhavi, additional, Kissoon, Niranjan (Tex), additional, Kon, Alexander A., additional, Kutko, Martha C., additional, MacLaren, Graeme, additional, Maul, Timothy, additional, Mehta, Renuka, additional, Odetola, Fola, additional, Parbuoni, Kristine, additional, Paul, Raina, additional, Peters, Mark J., additional, Ranjit, Suchitra, additional, Reuter-Rice, Karin E., additional, Schnitzler, Eduardo J., additional, Scott, Halden F., additional, Torres, Adalberto, additional, Weingarten-Abrams, Jacki, additional, Weiss, Scott L., additional, Zimmerman, Jerry J., additional, and Zuckerberg, Aaron L., additional
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- 2017
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21. Botulism in the Pediatric Intensive Care Units in the United States: Interrogating a National Database
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Howes, Cynthia, Hiatt, Kerith, Turlington, Katherine, Foster, Cortney, Holloway, Adrian, Graciano, Ana Lia, Custer, Jason, Bhutta, Adnan, and Bagdure, Dayanand
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- 2020
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22. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-[Alpha] transgenic mice
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GRACIANO, ANA LIA, BRYANT, DEBORA D., WHITE, D. JEAN, HORTON, JURETA, BOWLES, NEIL E., and GIROIR, BRETT P.
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Bacterial infections -- Research ,Congestive heart failure -- Physiological aspects ,Cytokines -- Research ,Endotoxins -- Research ,Biological sciences - Abstract
Graciano, Ana Lia, Debora D. Bryant, D. Jean White, Jureta Horton, Neil E. Bowles, and Brett P. Giroir. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-[Alpha] transgenic mice. Am J Physiol Heart Circ Physiol 280: H1464-H1471, 2001.--We have developed a transgenic mouse model in which tumor necrosis factor (TNF)-[Alpha] is overexpressed exclusively in the heart under the regulation of the [Alpha]-myosin heavy chain promoter. These animals develop chronic heart failure associated with severe leukocyte infiltration in both the atria and the ventricles. The purpose of this study was to investigate the role of adhesion molecules in mediating cardiac dysfunction in the TNF-[Alpha] transgenic model. TNF-[Alpha] transgenic mice were bred with mice null for intercellular adhesion molecule (ICAM)-1 and P-selectin genes to obtain a lineage of ICAM-1 and P-selectin null mice with selective overexpression of TNF-[Alpha] in the heart. TNF-[Alpha] transgenic animals showed marked upregulation of ICAM-1 mRNA and protein; however, P-selectin mRNA and protein remained undetectable despite chronic TNF overexpression. Cardiac function was markedly improved in the [ICAM-1.sup.-/-], [P-selectin.sup.-/-], TNF-[Alpha] transgenic group versus the [ICAM.sup.+/+], [P-selectin.sup.+/+], TNF-[Alpha] transgenic group. Kaplan-Meier survival curves showed statistically significant prolonged survival in the [ICAM-1.sup.-/-], [P-selectin.sup.-/-], TNF-[Alpha] transgenic animals. These data suggest that ICAM-1 mediates at least in part the cardiac dysfunction induced by TNF-[Alpha] expression by cardiac myocytes. sepsis; congestive heart failure; cytokines; endotoxin
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- 2001
23. Coccidioidomycosis in infants: A retrospective case series
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Lee, Jessica M., primary, Graciano, Ana Lia, additional, Dabrowski, Lukasz, additional, Kuzmic, Brenik, additional, and Tablizo, Mary Anne, additional
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- 2016
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24. Harms Associated with Tracheal Reintubation After Unplanned Extubation: A Retrospective Cohort Study
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Malone, Mathew P., Harwayne-Gidansky, Ilana, Sanders, Ronald C., Napolitano, Natalie, Pham, Jennifer, Polikoff, Lee, Register, Melinda, Tarquinio, Keiko M., Shults, Justine, Krawiec, Conrad, Mallory, Palen, Breuer, Ryan K., Shenoi, Asha N., Wollny, Krista, Parsons, Simon J., Kandil, Sarah B., Pinto, Matthew, Gladen, Kelsey M., Dewan, Maya, Graciano, Ana Lia, Nett, Sholeen, Giuliano, John S., Krishna, Ashwin S., Ducharme-Crevier, Laurence, Talukdar, Andrea, Lee, Jan Hau, Miksa, Michael, Lee, Anthony, Ahmed, Aziez, Page-Goertz, Christopher, Jung, Philipp, Scott, Briana L., Kelly, Serena P., Al-Subu, Awni, Spear, Debbie, Allen, Lauren, Sizemore, Johnna, Kasagi, Mioko, Nagai, Yuki, Toal, Megan, Biagas, Katherine, Nadkarni, Vinay, and Nishisaki, Akira
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- 2024
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25. 444
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Lee, Jessica, primary, Tablizo, Mary Anne, additional, McCarthy, James, additional, and Graciano, Ana Lia, additional
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- 2015
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26. Chapter 27 - Myocardial Dysfunction, Ventricular Assist Devices, and Extracorporeal Life Support
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Hanson, Cherissa, Kocis, Keith C., and Graciano, Ana Lía
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- 2011
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27. Contributors
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Abecassis, Isaac Josh, Agbeko, Rachel S., Adelson, P. David, Alder, Matthew N., Al Ibrahim, Omar, Almodovar, Melvin C., Aminoff, Alexandra R., Amlie-LeFond, Catherine, Angus, Derek C., Arvedson, Joan C., Aspesberro, Francois, Baatz, John E., Baden, Harris P., Badugu, Srinivasarao, Bakar, Adnan M., Banker, Katherine, Bass, John L., Bayir, Hülya, Beaulieu, Pierre, Becker, Lance B., Bell, Michael J., Bender, M.A., Benton, Wade W., Berg, Robert A., Biagas, Katherine V., Bishop, Naomi B., Blatt, Julie, Blowey, Douglas L., Blumer, Jeffrey L., Bonow, Robert H., Brandom, Barbara W., Brilli, Richard J., Brogan, Thomas V., Bronicki, Ronald A., Browd, Samuel R., Bunchman, Timothy E., Burns, Jeffrey P., Caglar, Derya, Campbell, Sally, Carcillo, Joseph A., Carrillo-Lopez, Hector, Cashen, Katherine, Cassara, Antonio, Charpie, John R., Chavez, Adrian, Chun, Robert H., Clark, Jonna Derbenwick, Clark, Robert S.B., Clement, Katherine C., Conlon, Thomas, Conway, Edward E., Jr., Coopersmith, Craig M., Corey, Seth J., Cox, Peter N., Curley, Martha A.Q., Czosnyka, Marek, Dalton, Heidi J., Damian, Mihaela, Davis, Peter J., de Prost, Nicolas, Deutschman, Clifford S., Dezfulian, Cameron, Diekema, Douglas S., Doctor, Allan, Doherty, Meaghan, Dorfman, Molly V., Downes, John J., Dreyfuss, Didier, Duncan, Christine, Dupree, Phylicia D., Eigen, Howard, El-Hassan, Nahed, Eriksson, Carl O., Felmet, Kate, Fineman, Jeffrey R., Fink, Ericka L., Fish, Frank A., Fitzgerald, Tamara N., Flynn, Joseph T., Pérez Fontán, J. Julio, Forbes, Michael J., Forbess, Joseph M., Franzon, Deborah E., Frazier, W. Joshua, Fricker, F. Jay, Fuhrman, Bradley P., Garcia-Casal, Xiomara, Gardner, Rebecca, Gilad, Eli, Ginther, Richard M., Jr., Glaser, Nicole, Goodman, Denise M., Graciano, Ana Lía, Greathouse, Kristin C., Greenwald, Bruce M., Gunnarsson, Björn, Gupta, Punkaj, Hall, Mark W., Han, Yong Y., Harding, Cary O., Hartman, Mary E., Hartmann, Silvia M., Heard, Christopher M.B., Hernan, Lynn J., Heulitt, Mark J., Hoffman, Julien I., Horslen, Simon, Hunyady, Agnes I., Ibsen, Laura Marie, IJsselstijn, Hanneke, Inglis, Andrew, Jr., Irby, Gretchen A. Linggi, Irby, Olivia K., Ishak, Gisele E., Jackson, Travis C., Jacob, Susan, Jamal, Shelina M., Jardine, David, Jarillo, Alberto, Jeziorski, Alison M., Joashi, Umesh, Joshi, Prashant, Kagan, Richard J., Kannankeril, Prince J., Kanter, Robert K., Karam, Oliver, Kaspar, Cristin D.W., Khemani, Robinder G., King, Mary A., Kirk, Christa C. Jefferis, Kissoon, Niranjan (Tex), Kochanek, Patrick M., Kocis, Keith C., Kocoshis, Samuel A., Koh, Tsingyi, Kong, Ada, Koves, Ildiko H., Kulik, Thomas J., Kumar, Vasanth H., Lacroix, Jacques, Lakshminrusimha, Satyan, Lee, Thomas J., Leiner, Marie, Levin, Daniel L., Lewis-Newby, Mithya, Lieh-Lai, Mary W., Litalien, Catherine, Lopez-Magallon, Alejandro, Lynch, Robert, Lyons, John D., Maiyegun, Sitratullah, Makley, Amy T., Maldonado, Alfredo, Markovitz, Barry, Mazur, Paula M., McArthur, Jennifer, McLaughlin, Gwenn E., McLean, Susan F., Mehta, Nilesh M., Mehta, Renuka, Melvin, Ann J., Mian, Ayesa N., Mittal, Rohit, Moloney-Harmon, Patricia A., Monagle, Paul, Moorthy, Chet, Morrison, Wynne, Munoz, Ricardo, Munshi, Raj, Murthy, Srinivas, Muszynski, Jennifer A., Nadkarni, Vinay M., Nakagawa, Thomas A., Naran, Navyn, Neumayr, Tara M., Nishisaki, Akira, Norwood, Victoria F., Notterman, Daniel A., Nugent, Alan W., Oishi, Peter, Ojemann, Jeffrey, Orr, Richard A., Ouellette, Yves, Parakininkas, Daiva, Parker, Robert I., Pasala, Sanjiv, Pearson-Shaver, Tony, Peinado, Jesus, Peters, Mark J., Pfeiffer, Brent J., Phillipi, Carrie A., Pinsk, Maury N., Pollack, Murray M., Pon, Steven, Preston, Tom, Rajapreyar, Prakad, Ray, Samiran, Reade, Erin P., Remy, Kenneth E., Rhee, Eileen, Ricard, Jean-Damien, Richardson, Nicole L., Roberts, Joan S., Rogers, Stephen, Roth, Kimberly R., Rotta, Alexandre T., Rowin, Mark E., Rubin, Lewis P., Ruppel, Randall, Ryan, Rita M., Said, Ahmed, Sainte-Thomas, Nagela, Salonia, Rosanne, Sambalingam, Devaraj, Nelson Sanchez-Pinto, L., Sandquist, Mary, Sarnaik, Ajit A., Sarnaik, Ashok P., Saumon, Georges, Sawin, Robert, Scanlon, Matthew C., Schenkman, Kenneth A., Schexnayder, Stephen M., Schleien, Charles L., Schwartz, George J., Schwartz, Steven M., Schwenk, Hayden T., Seibel, Gabrielle Douthitt, Shaw, Dennis W.W., Shein, Steven L., Shepard, Charles W., Shoykhet, Michael, Simon, Dennis W., Sivarajan, V. Ben, Skippen, Peter, Smith, Lincoln S., Spaeder, Michael C., Speicher, Richard H., Spinella, Philip C., Standage, Stephen, Steinhorn, David M., Stewart, Claire, Storm, Elizabeth A., Stroud, Michael H., Su, Erik, Sutton, Robert M., Symons, Jordan M., Talano, Julie-An, Tamburro, Robert T., Jr., Tasker, Robert C., Thompson, Ann E., Tilton, Ann H., Tobias, Joseph D., Todres, I. David, Torgerson, Troy, Traube, Chani, Tucci, Marisa, Turner, David A., Tyroch, Alan H., Cleave, Alisa Van, van der Velden, Meredith G., Vaughan, David J., Vazquez, Erika, Venkataraman, Shekhar T., Visoiu, Mihaela, von Saint André-von Arnim, Amélie, Vora, Surabhi B., Waghmare, Alpana, Wainwright, Mark S., Wakeham, Martin, Wallace, Carol A., Wallisch, Jessica S., Watson, R. Scott, Webb, Ashley N., Weiss, Scott L., Wenger, Jesse, Wheeler, Derek S., Wilson, Harry, Wong, Hector R., Wood, Ellen Glenn, Woolf, Alan D., Yaghmai, Beryl F., Yanay, Ofer, Zerr, Danielle M., Zheng, Hengqi (Betty), and Zimmerman, Jerry J.
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- 2017
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28. Family Presence During Pediatric Tracheal Intubations.
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Sanders Jr, Ronald C., Nett, Sholeen T., Davis, Katherine Finn, Parker, Margaret M., Bysani, G. Kris, Adu-Darko, Michelle, Bird, Geoffrey L., Cheifetz, Ira M., Derbyshire, Ashley T., Emeriaud, Guillaume, Giuliano Jr, John S., Graciano, Ana Lia, Yusuke Hagiwara, Hefley, Glenda, Ikeyama, Takanari, Jarvis, J. Dean, Kamat, Pradip, Krishna, Ashwin S., Lee, Anthony, and Jan Hau Lee
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- 2016
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29. 307
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Rodriguez, Raul, primary, Banerjee, Swati, additional, Zuniga, Stephen, additional, and Graciano, Ana Lia, additional
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- 2012
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30. Vitamin D Deficiency Is Associated With Mortality In Patients Admitted To The Pediatric Intensive Care Unit With Community-Acquired Influenza Infection
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Randolph, Adrienne G., primary, Guo, Chao-Yu, additional, Jouvet, Philippe, additional, Ferdinands, Jill, additional, Weiss, Scott T., additional, Flori, Heidi, additional, Loftis, Laura, additional, Yoon, Grace, additional, Anas, Nicholas, additional, Helfaer, Mark, additional, Paden, Matthew, additional, Willson, Douglas, additional, Hall, Mark, additional, Hollis, Bruce W., additional, Dowling, Nicole, additional, Sullivan, Ryan, additional, Carroll, Christopher L., additional, Czaja, Angela, additional, Truemper, Edward, additional, Katyal, Chhavi, additional, Thomas, Neal, additional, Graciano, Ana Lia, additional, Montgomery, Vicky, additional, Markovitz, Barry, additional, Gedeit, Rainer, additional, and Shay, David K., additional
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- 2010
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31. 537: BILATERAL CEREBRAL STROKES AND ADRENAL HEMORRHAGE ASSOCIATED WITH MIS-A.
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Kandeepan, Aarani, Holloway, Adrian, and Graciano, Ana Lia
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- 2023
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32. 108: INFLUENCE OF COVID-19 ON BURNOUT AMONG CRITICAL CARE ADVANCED PRACTICE PROVIDERS.
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Avadhani, Amita, Akuamoah-Boateng, Kwame, Lizano, Danny, Sandor, Peter, Westwick-Butcher, Amy, Newman, Christopher, Samanta, Damayanti, and Graciano, Ana Lia
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- 2023
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33. 107: CURRENT LANDSCAPE OF ADVANCED PRACTICE PROVIDERS IN CRITICAL CARE.
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Butcher, Amy, Sandor, Peter, Graciano, Ana Lia, Lizano, Danny, Samanta, Damayanti, Akuamoah-Boateng, Kwame, Avadhani, Amita, and Newman, Christopher
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- 2023
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34. Development of a Quality Improvement Bundle to Reduce Tracheal Intubation-Associated Events in Pediatric ICUs.
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Li, Simon, Rehder, Kyle J., Giuliano, John S., Apkon, Michael, Kamat, Pradip, Nadkarni, Vinay M., Napolitano, Natalie, Thompson, Ann E., Tucker, Craig, Nishisaki, Akira, Pradip, Kamat, Graciano, Ana Lia, Lee, Anthony, Derbyshire, Ashley, Brown, Calvin A., Goltzman, Carey, Turner, David A., Spear, Debra, Emeriaud, Guillaume, and Cheifetz, Ira M.
- Abstract
Advanced airway management in the pediatric intensive care unit (PICU) is hazardous, with associated adverse outcomes. This report describes a methodology to develop a bundle to improve quality and safety of tracheal intubations. A prospective observational cohort study was performed with expert consensus opinion of 1715 children undergoing tracheal intubation at 15 PICUs. Baseline process and outcomes data in tracheal intubation were collected using the National Emergency Airway Registry for Children reporting system. Univariate analysis was performed to identify risk factors associated with adverse tracheal intubation-associated events. A multidisciplinary quality improvement committee was formed. Workflow analysis of tracheal intubation and pilot testing were performed to develop the Airway Bundle Checklist with 4 parts: (1) risk factor assessment, (2) plan generation, (3) preprocedure time-out to ensure that providers, equipment, and plans are prepared, (4) postprocedure huddle to identify improvement opportunities. The Airway Bundle Checklist developed may lead to improvement in airway management. [ABSTRACT FROM AUTHOR]
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- 2016
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35. The Pediatric Multiple Organ Dysfunction Score (P-MODS): Development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children*
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Graciano, Ana Lia, primary, Balko, James A., additional, Rahn, Donna S., additional, Ahmad, Naveed, additional, and Giroir, Brett P., additional
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- 2005
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36. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-α transgenic mice
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Graciano, Ana Lia, primary, Bryant, Debora D., additional, White, D. Jean, additional, Horton, Jureta, additional, Bowles, Neil E., additional, and Giroir, Brett P., additional
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- 2001
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37. Contributors
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Ackerman, Veda L., Adelson, P. David, Agbeko, Rachel S., Almodovar, Melvin C., Alonso, Estella M., Aneja, Raj K., Angus, Derek C., Argent, Andrew C., Aspesberro, Francois P., Bakar, Adnan M., Bambach, Barbara, Bass, Lee M., Bayir, Hülya, Beaulieu, Pierre, Bell, Michael J., Bender, M.A., Benson, Jeffrey C., Benton, Wade W., Berg, Robert A., Berkowitz, Darryl H., Bhutta, Omar J., Biagas, Katherine C., Blatt, Julie, Blowey, Douglas L., Blumer, Jeffrey L., Bradley, John S, Brandom, Barbara W., Brodsky, Linda, Brogan, Thomas V., Brothers, Adam W., Bunchman, Timothy E., Burd, Randall S., Burns, Jeffrey, Bush, Sean P., Bystrak, Louis L., Campbell, Angela J.P., Cannavino, Christopher R., Carcillo, Joseph A., Carrillo-Lopez, Hector, Cassara, Antonio, Caty, Michael G., Charpie, John R., Chavez, Adrian, Christenson, John C., Clark, Jonna D., Clark, Robert S.B., Clement, Katherine C., Coalson, Jacqueline J., Coopersmith, Craig M., Coppola, Christopher P., Corey, Seth J., Cox, Peter N., Cummings, James J., Curley, Martha A.Q., Czosnyka, Marek, D’Angelis, Christopher A., Dahmer, Mary K., Dalton, Heidi J., Davis, Peter J., Morena, M. Theresa de la, Oliveira, Cláudio Flauzino de, Dhanani, Sonny, Dobyns, Emily L., Donner, Elizabeth J., Doughty, Lesley, Dreyfuss, Didier, Duncan, Christine, Durand, Philippe, Duthie, Susan, Eigen, Howard, Maamoun El-Dawy, Waleed M., Elliott, Steven, Emery, Helen M., Escobar, Mauricio A., Jr., Evans, Jacqueline M., Felmet, Kate, Fineman, Jeffrey R., Fink, Ericka L., Fiser, Richard T., Fish, Frank A., Fletcher, James E., Forbes, Michael J., Fort, Amber E., Fost, Norman, Frader, Joel E., Franzon, Deborah E., Fricker, F. Jay, Friess, Stuart, Fuhrman, Bradley P., Garcia-Casal, Xiomara, Gauvin, France, Gaynor, J. William, Gilad, Eli, Gilbert, James C., Glaser, Nicole S., Goldstein, Stuart L., Goodman, Denise M., Graciano, Ana Lía, Gunnarsson, Björn, Hahn, Cecil D., Hall, Mark, Hamilton, Melinda Fiedor, Han, Yong Y., Hanson, Cherissa, Harding, Cary O., Hartman, Mary E., Hazelzet, Jan A., Heard, Christopher M.B., Heine, Ann Marie, Hernan, Lynn J., Hertzig, Jeremy S., Heulitt, Mark J., Hoffman, Julien I.E., Huhta, James C., Ichord, Rebecca, Inglis, Andrew, Linggi Irby, Gretchen A., Jacobs, Brian, Jardine, David, Jarillo-Quijada, Alberto, Javouey, Etienne, Jefferis Kirk, Christa C., Johns, James A., Joshi, Prashant, Kagan, Richard J., Kannankeril, Prince J., Kanter, Robert K., Karam, Oliver, Kasten, Kevin R., Kelly, Michael, Khanna, Paritosh C., Kochanek, Patrick M., Kocis, Keith C., Kocoshis, Samuel A., Koves, Ildiko H., Kulik, Thomas J., Kumar, Vasanth H., Lacroix, Jacques, Lakshminrusimha, Satyan, Langley, Joanne M., Laussen, Peter C., Levin, Daniel L., Lewis-Newby, Mithya, Lieh-Lai, Mary W., Lindsey, Daphne, Litalien, Catherine, Lynch, Robert E., Makley, Amy T., Marcin, James P., Mariscalco, Mary Michele, Markovitz, Barry, Martin, Lynn D., Maxvold, Norma J., Mazur, Paula M., McArthur, Jennifer A., McLaughlin, Jerry, McLaughlin, Gwenn E., Redwine, Karen McNiece, Mehta, Nilesh M., Mehta, Renuka, Melvin, Ann J., Menon, Sharad, Mian, Ayesa N., Michelson, Kelly, Michienzi, Kelly A., Moloney-Harmon, Patricia A., Monagle, Paul, Moss, Michele M., Mou, Steven S., Muenzer, Jared T., Nadkarni, Vinay, Nakagawa, Thomas A., Naran, Navyn, Nguyen, Trung, Nicholson, Carol E., Nielsen, Katie R., Northway, Tracie, Norwood, Victoria F., Notterman, Daniel A., Nowak, Jeffrey E., Oishi, Peter, Orr, Richard A., Ouellette, Yves, Parakininkas, Daiva, Parker, Margaret M., Pearson-Shaver, Tony, Pérez Fontán, J. Julio, Peters, Mark, Pihoker, Catherine, Pinsk, Maury N., Pollack, Murray M., Pon, Steven, Quasney, Michael, Rajasekaran, Surender, Rampersad, Sally E., Ranjit, Suchitra, Reade, Erin P., Reese Jr., James J., Relvas, Monica, Remy, Kenneth E., Ricard, Jean-Damien, Rice, Tom B., Ridling, Debra Ann, Roberts, Joan S., Ross, Ashley S., Roth, Kimberly R., Rotta, Alexandre T., Rowin, Mark E., Roy, John, Rubino, Christopher M., Ruppel, Randall A., Rushton, Cynda H., Ryan, Rita M., Salonia, Rosanne, Salvin, Joshua, Sanders Jr., Ronald C., Sarnaik, Ajit A., Sarnaik, Ashok P., Saumon, Georges, Sawin, Robert, Scanlon, Matthew C., Schenkman, Kenneth A., Schexnayder, Stephen M., Schleien, Charles L., Schwartz, George J., Schwartz, Steven M., Shann, Frank, Shaw, Dennis W.W., Shemie, Sam D., Shoykhet, Mish, Sivarajan, V. Ben, Skippen, Peter W., Slonim, Anthony D., Smith, Laurie, Smith, Lincoln S., Standage, Stephen W., Steinberg, Joel B., Steinhorn, David M., Stojanovski, Sasko D., Storm, Elizabeth A., Stroud, Michael H., Sturgill, Marc G., Sutton, Robert M., Symons, Jordan M., Tailounie, Muayyad, Talano, Julie-An, Tamburro Jr., Robert, Tasker, Robert C., Thompson, Ann E., Tilton, Ann H., Tinmouth, Alan, Tobias, Joseph D., Tobin, Nicole H., Todres, I. David, Tucci, Marisa, Ulate, Kalia P., Valentine, Kevin M., Vaughan, David J., Venkataraman, Shekhar T., Visoiu, Mihaela, von Saint André–von Arnim, Amélie, Wainwright, Mark S., Wakeham, Martin K., Watson, R. Scott, Webb, Ashley N., Weigle, Carl, Weimer, Maria B., Wessel, David L., Wetzel, Randall C., Wong, Hector R., Wood, Ellen G., Woolf, Alan D., Woytash, James J., Yanay, Ofer, Zaritsky, Arno, Zerr, Danielle M., and Zimmerman, Jerry J.
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- 2011
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38. Extracorporeal Membrane Oxygenation Characteristics and Outcomes in Children and Adolescents With COVID-19 or Multisystem Inflammatory Syndrome Admitted to U.S. ICUs.
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Bembea MM, Loftis LL, Thiagarajan RR, Young CC, McCadden TP, Newhams MM, Kucukak S, Mack EH, Fitzgerald JC, Rowan CM, Maddux AB, Kolmar AR, Irby K, Heidemann S, Schwartz SP, Kong M, Crandall H, Havlin KM, Singh AR, Schuster JE, Hall MW, Wellnitz KA, Maamari M, Gaspers MG, Nofziger RA, Lim PPC, Carroll RW, Coronado Munoz A, Bradford TT, Cullimore ML, Halasa NB, McLaughlin GE, Pannaraj PS, Cvijanovich NZ, Zinter MS, Coates BM, Horwitz SM, Hobbs CV, Dapul H, Graciano AL, Butler AD, Patel MM, Zambrano LD, Campbell AP, and Randolph AG
- Subjects
- Adult, Humans, Child, Adolescent, SARS-CoV-2, Hospitalization, Intensive Care Units, Retrospective Studies, COVID-19 therapy, Extracorporeal Membrane Oxygenation
- Abstract
Objectives: Extracorporeal membrane oxygenation (ECMO) has been used successfully to support adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related cardiac or respiratory failure refractory to conventional therapies. Comprehensive reports of children and adolescents with SARS-CoV-2-related ECMO support for conditions, including multisystem inflammatory syndrome in children (MIS-C) and acute COVID-19, are needed., Design: Case series of patients from the Overcoming COVID-19 public health surveillance registry., Setting: Sixty-three hospitals in 32 U.S. states reporting to the registry between March 15, 2020, and December 31, 2021., Patients: Patients less than 21 years admitted to the ICU meeting Centers for Disease Control criteria for MIS-C or acute COVID-19., Interventions: None., Measurements and Main Results: The final cohort included 2,733 patients with MIS-C ( n = 1,530; 37 [2.4%] requiring ECMO) or acute COVID-19 ( n = 1,203; 71 [5.9%] requiring ECMO). ECMO patients in both groups were older than those without ECMO support (MIS-C median 15.4 vs 9.9 yr; acute COVID-19 median 15.3 vs 13.6 yr). The body mass index percentile was similar in the MIS-C ECMO versus no ECMO groups (89.9 vs 85.8; p = 0.22) but higher in the COVID-19 ECMO versus no ECMO groups (98.3 vs 96.5; p = 0.03). Patients on ECMO with MIS-C versus COVID-19 were supported more often with venoarterial ECMO (92% vs 41%) for primary cardiac indications (87% vs 23%), had ECMO initiated earlier (median 1 vs 5 d from hospitalization), shorter ECMO courses (median 3.9 vs 14 d), shorter hospital length of stay (median 20 vs 52 d), lower in-hospital mortality (27% vs 37%), and less major morbidity at discharge in survivors (new tracheostomy, oxygen or mechanical ventilation need or neurologic deficit; 0% vs 11%, 0% vs 20%, and 8% vs 15%, respectively). Most patients with MIS-C requiring ECMO support (87%) were admitted during the pre-Delta (variant B.1.617.2) period, while most patients with acute COVID-19 requiring ECMO support (70%) were admitted during the Delta variant period., Conclusions: ECMO support for SARS-CoV-2-related critical illness was uncommon, but type, initiation, and duration of ECMO use in MIS-C and acute COVID-19 were markedly different. Like pre-pandemic pediatric ECMO cohorts, most patients survived to hospital discharge., Competing Interests: Dr. Bembea’s institution received funding from the National Institute of Neurological Disorders and Stroke (R01NS106292) and Grifols Investigator Sponsored Research Grant. Drs. Bembea, Heidemann, Zinter, and Randolph received support for article research from the National Institutes of Health (NIH). Dr. Thiagarjan’s institution received funding from the U.S. Department of Defense (Peer Reviewed Medical Research Project Clinical Trial Award No. W81XWH2210301 Trial of Indication-based Transfusion of Red blood cells in Extracorporeal Membrane Oxygenation); he received funding from Society of Critical Care Medicine and the Extracorporeal Life Support Organization. Drs. Young’s, McCadden’s, Newhams’s, Kucuak’s, Mack’s, Fitzgerald’s, Rowan’s, Maddux’s, Kolmar’s, Heidemann’s, Schwartz’s, Kong’s, Crandall’s, Singh’s, Schuster’s, Hall’s, Wellnitz’s, Maamari’s, Gaspers’s, Nofziger’s, Cullimore’s, Halasa’s, McLaughlin’s, Pannaraj’s, Cvijanovich’s, Coates’s, Horwitz’s, Hobbs’s, Dapul’s, and Randolph’s institutions received funding from the U.S. Centers for Disease Control and Prevention (CDC). Dr. McCadden disclosed work for hire. Dr. Newhams’ institution received funding from the National Institute of Allergy and Infectious Diseases. Drs. Fitzgerald’s, Kong’s, Cullimore’s, Cvijanovich’s, and Randolph’s institutions received funding from the NIH. Dr. Rowan’s institution received funding from the National Heart, Lung, and Blood Institute (NHLBI) (K23HL150244). Dr. Maddux’s institution received funding from the National Institute of Child Health and Human Development (K23HD096018). Drs. Irby, Crandall, Singh, Wellnitz, Nofziger, Bradford, McLaughlin, Coates, Hobbs, and Zambrano received support for article research from the CDC. Dr. Schuster’s institution received funding from Merck. Dr. Hall received funding from Abbvie, Kiadis, and the American Board of Pediatrics. Dr. Wellnitz’s institution received funding from the University of Pennsylvania (prime sponsor NIH) and the University of Nebraska (prime sponsor Administration for Strategic Preparedness and Response). Dr. Gaspers received funding from Abbott Laboratories. Dr. Munoz’s institution received funding from Boston’s Children’s Hospital; he received funding from the University of Texas Health Science Center at Houston. Dr. Halasa’s institution received funding from Sanofi. Dr. McLaughlin received funding from expert witness fees from two entities. Dr. Pannaraj’s institution received funding from AstraZeneca and Pfizer. Dr. Coates’ institution received funding from the NHLBI and the American Lung Association; she received funding from Sobi. Drs. Hobbs and Randolph received funding from UpToDate. Dr. Hobbs received funding from Dynamed.com; she disclosed that she was a speaker for Biomerieux 2021–2022. Drs. Zambrano and Campbell disclosed government work. Dr. Randolph had full access to all the data in the investigation and takes responsibility for the integrity of the data and the accuracy of the data analysis. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
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- 2023
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39. Critically ill children during the 2009-2010 influenza pandemic in the United States.
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Randolph AG, Vaughn F, Sullivan R, Rubinson L, Thompson BT, Yoon G, Smoot E, Rice TW, Loftis LL, Helfaer M, Doctor A, Paden M, Flori H, Babbitt C, Graciano AL, Gedeit R, Sanders RC, Giuliano JS, Zimmerman J, and Uyeki TM
- Subjects
- Adolescent, Child, Child, Preschool, Critical Illness, Female, Humans, Infant, Influenza, Human complications, Influenza, Human diagnosis, Male, Retrospective Studies, United States epidemiology, Young Adult, Influenza A Virus, H1N1 Subtype, Influenza, Human epidemiology, Pandemics
- Abstract
Background: The 2009 pandemic influenza A (H1N1) (pH1N1) virus continues to circulate worldwide. Determining the roles of chronic conditions and bacterial coinfection in mortality is difficult because of the limited data for children with pH1N1-related critical illness., Methods: We identified children (<21 years old) with confirmed or probable pH1N1 admitted to 35 US PICUs from April 15, 2009, through April 15, 2010. We collected data on demographics, baseline health, laboratory results, treatments, and outcomes., Results: Of 838 children with pH1N1 admitted to a PICU, the median age was 6 years, 58% were male, 70% had ≥1 chronic health condition, and 88.2% received oseltamivir (5.8% started before PICU admission). Most patients had respiratory failure with 564 (67.3%) receiving mechanical ventilation; 162 (19.3%) received vasopressors, and 75 (8.9%) died. Overall, 71 (8.5%) of the patients had a presumed diagnosis of early (within 72 hours after PICU admission) Staphylococcus aureus coinfection of the lung with 48% methicillin-resistant S aureus (MRSA). In multivariable analyses, preexisting neurologic conditions or immunosuppression, encephalitis (1.7% of cases), myocarditis (1.4% of cases), early presumed MRSA lung coinfection, and female gender were mortality risk factors. Among 251 previously healthy children, only early presumed MRSA coinfection of the lung (relative risk: 8 [95% confidence interval: 3.1-20.6]; P < .0001) remained a mortality risk factor., Conclusions: Children with preexisting neurologic conditions and immune compromise were at increased risk of pH1N1-associated death after PICU admission. Secondary complications of pH1N1, including myocarditis, encephalitis, and clinical diagnosis of early presumed MRSA coinfection of the lung, were mortality risk factors.
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- 2011
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