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187 results on '"Graf, Heiko"'

3. Adjuvant capecitabine versus nihil in older patients with node-positive/high-risk node-negative early breast cancer receiving ibandronate – The ICE randomized clinical trial

Author

Schmidt, Marcus, Nitz, Ulrike, Reimer, Toralf, Schmatloch, Sabine, Graf, Heiko, Just, Marianne, Stickeler, Elmar, Untch, Michael, Runnebaum, Ingo, Belau, Antje, Huober, Jens, Jackisch, Christian, Hofmann, Manfred, Krocker, Jutta, Nekljudova, Valentina, and Loibl, Sibylle

Published
2023
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9. Sexual Dysfunction Induced by Antidepressants—A Pharmacovigilance Study Using Data from VigiBase TM.

Author

Zeiss, Rene, Malejko, Kathrin, Connemann, Bernhard, Gahr, Maximilian, Durner, Verena, and Graf, Heiko

Subjects
SEROTONIN uptake inhibitors, DRUG side effects, NEUROTRANSMITTER receptors, SEROTONIN transporters, SEXUAL dysfunction, ANTIDEPRESSANTS
Abstract

Sexual dysfunction is a common side effect of antidepressants, significantly impacting patients' quality of life and treatment adherence. This study investigates the relationship between sexual dysfunction and antidepressants by analyzing data from VigiBase™, the World Health Organization's global database of individual case safety reports. In this study, we examined, for the first time, reports related to sexual response—desire, arousal, and orgasm—by grouping appropriate side effect terms and calculated the reporting odds ratios (RORs) for various antidepressants. The findings of this study highlight a high disproportional reporting of sexual dysfunction, particularly with selective serotonin reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors. In contrast, agents such as agomelatine, bupropion, and mirtazapine showed a lower association. Furthermore, we investigated the correlation between reporting odds ratios and the binding affinities of antidepressants to specific neurotransmitter receptors and transporters, unveiling significant relationships that provide insights into the pharmacodynamic pathways underlying these adverse effects. For instance, a positive correlation was observed between the serotonin transporter and side effects in the category desire: r (19) = 0.67, p = 0.001 These insights underscore the necessity for clinicians to consider sexual side effects when prescribing antidepressants and to monitor and address these issues to improve patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis

Author

Saberi, Amin, primary, Ebneabbasi, Amir, additional, Rahimi, Sama, additional, Sarebannejad, Sara, additional, Sen, Zumrut Duygu, additional, Graf, Heiko, additional, Walter, Martin, additional, Sorg, Christian, additional, Camilleri, Julia A, additional, Laird, Angela R., additional, Fox, Peter T, additional, Valk, Sofie L, additional, Eickhoff, Simon B, additional, and Tahmasian, Masoud, additional

Published
2023
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12. Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial

Author

Vandebroek, An, Berliere, Martine, Mitine, Carine, Vuylsteke, Peter, Borms, Marleen, D'Hondt, Randal, Glorieux, Philippe, Mebis, Jeroen, Verhoeven, Didier, Coibion, Michael, Forget, Frederic, Duck, Lionel, Wyendaele, Wim, Barbeaux, Annelore, Salmon, Jean-Paul, Berteloot, Patrick, Vermeij, Joanna, Richard, Vincent, Cinieri, Saverio, Gianni, Lorenzo, Clerico, Mario, Pinotti, Graziella, Bernardo, Antonio, Biganzoli, Leo, Gennari, Alessandra, Graiff, Claudio, Amadori, Dino, Passalacqua, Rodolfo, Forbes, John, Francis, Prudence, Foo, Serene, Boyle, Frances, Redfern, Andrew, van der Westhuizen, Andre, Lewis, Craig, Sharma, Sharad, Beale, Philip, Byard, Ian, Begbie, Stephen, Sardelic, Frank, Abdi, Ehtesham, Clark, David, Chindewere, Aaron, Della-Fiorentina, Stephen, Asghari, Ray, Islam, Mohammed, Na Teo, Lee, White, Shane, Gilbert, Linda, Gardner, Katherine, Uhlmann, Catarina, Rauch, Daniel, Mannhart, Meinrad, Buser, Katharina, Dedes, Konstantin, Mueller, Andreas, Rageth, Christoph, Von Orelli, Stephanie, Senn, Hans Joerg, Pagani, Olivia, Pedrazzini, Augusto, Rochlitz, Christoph, Bodmer, Alexandre, Anchisi, Sandro, Zaman, Khalil, von Moos, Roger, Betticher, Daniel, Kralidas, Elena, Popescu, Razven, Fehr, Mathias, Nyman, Per, Jungquist, Anja, Chamalidou, Chaido, Foukakis, Theodoros, Dabrosin, Charlotta, Valachis, Antonis, Lang, Istvan, Kahan, Zsuzsanna, Retamales, Javier, Torres, Ulloa Roberto, Fritis, Marcela, Sole, Sebastian, Torres, Soledad, Letzkus, Jaime, Escobar, Paula, Vigneaux, Ines, Arancibia, Jorge, Cardemil, Juana Bernardita, Huidobro, Patricio, Gomez, Henry, Wetter, Julie, Vorobiof, Daniel, McMichael, Gary, Apffelstaedt, Justus, Vorotnikov, Igor, Schwartz, Joel, Openshaw, Thomas, Bonnefoi, Herve, Jacquin, Jean-Philippe, Bonichon-Lamichhane, Natalie, Borstner, Simona, Budrukkar, Ashwini, Ewertz, Marianne, Quispe, Oscar Zambrano, Vestlev, Peter Michael, Danø, Hella, Nielsen, Ditte, Jakobsen, Erik, Hoejris, Inger, Bogovic, Jurij Antonovic, Jensen, Britta Bjerregaard, Aage Møller, Knud, Stenbygaard, Eric Lars, Sharma, Ravi, Bedi, Carolyn, Bews-Hair, Maria, Neades, Glyn, McKirdy, Mike, Barber, Matthew, Alhasso, Abdulla, Ritchie, Diana, Fraser, Judith, Scott, Lucy, Yuille, Frances, Lannigan, Alison, Murphy, Dermot, Shere, Mike, Jackisch, Christian, Tomé, Oliver, Steer, Susanne, Augustin, Doris, Lübbe, Kristina, Köcker-Korus, Heike, Deuker, Jörg-Uwe, Stefek, Andrea, Just, Marianne, Rhein, Uwe, Bechtner, Christina, Baerens, Dirk-Toralf, Schrader, Iris, Grischke, Eva-Maria, Lorenz, Ralf, Dietz, Wolfgang, Thomalla, Jörg, Schilling, Jörg, Rempen, Andreas, Graf, Heiko, Doering, Gabriele, Busch, Steffi, Heinrich, Georg, Tesch, Hans, Uleer, Christoph, Krabisch, Petra, Rösel, Siegfried, Kurbacher, Christian, Ostertag, Horst, Josten, Klaus-M, Hielscher, Carsten, Gröll, Isolde, Mattner, Ute Marie, Prechtl, Anita, Lantzsch, Tilmann, Ciruelos, Eva, Garau, Isabel, Bellet, Meritxell, Climent, Miguel Angel, López, Rafael, Virizuela, Juan Antonio, Bermejo, Begoña, Janez, Noelia Martinez, Amillano, Kepa, Márquez, Raúl, Dorca, Joan, Godes, Maria Jose, Gonzalez, Santiago, Ohno, Shinji, Aruga, Tomoyuki, Yotsumoto, Daisuke, Yamamoto, Yutaka, Aihara, Tomohiko, Morimoto, Takashi, Bando, Hiroko, Masuda, Norikazu, Toi, Masakazu, Aogi, Kenjiro, Sato, Nobuaki, Okada, Morihito, Takahashi, Masato, Tokunaga, Eriko, Iwata, Hiroji, Fujita, Takashi, Fridrik, Michael, Pristauz, Gunda, Hackl, Claudia, Singer, Christian, Wette, Victor, Gnant, Michael, Thaler, Josef, Greil, Richard, Abendstein, Burghard, Heck, Dietmar, Manfreda, Diether, Sevelda, Paul, Thiel, Irene, Tuttlies, Frank, Stöger, Herbert, Neunteufel, Walter, Crown, John, Kennedy, John, Hill, Arnold, McCaffrey, John, Murphy, Conleth, Coate, Linda, Keane, Maccon, Martin, Michael, O'Connor, Miriam, Duffy, Karen, Ruepp, Barbara, Piccart, Martine, Zardavas, Dimitrios, Colleoni, Marco, Luo, Weixiu, Karlsson, Per, Chirgwin, Jacquie, Aebi, Stefan, Jerusalem, Guy, Neven, Patrick, Hitre, Erika, Graas, Marie-Pascale, Simoncini, Edda, Kamby, Claus, Thompson, Alastair, Loibl, Sibylle, Gavilá, Joaquín, Kuroi, Katsumasa, Marth, Christian, Müller, Bettina, O'Reilly, Seamus, Di Lauro, Vincenzo, Gombos, Andrea, Ruhstaller, Thomas, Burstein, Harold, Ribi, Karin, Bernhard, Jürg, Viale, Giuseppe, Maibach, Rudolf, Rabaglio-Poretti, Manuela, Gelber, Richard D, Coates, Alan S, Di Leo, Angelo, Regan, Meredith M, and Goldhirsch, Aron

Published
2018
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13. Safety and tolerability of subcutaneous trastuzumab for the adjuvant treatment of human epidermal growth factor receptor 2-positive early breast cancer: SafeHer phase III study's primary analysis of 2573 patients

Author

Koroveshi, Dhurata, Bouzid, Kamel, Casalnuovo, Monica, Cascallar, Diana, Korbenfeld, Ernesto Pablo, Bastick, Patricia, Beith, Jane, Colosimo, Maree, Friedlander, Michael, Ganju, Vinod, Green, Michael, Patterson, Kevin, Redfern, Andrew, Richardson, Gary, Ceric, Timur, Gordana, Kecman, Beato, Carlos Augusto, Ferrari, Marcela, Hegg, Roberto, Helena, Vanessa, Ismael, Gustavo Fernando, Lessa, Alvaro Edson, Mano, Max, Morelle, Alessandra, Nogueira, Jose Alberto, Timcheva, Konstanta, Tomova, Antoaneta, Tsakova, Maya, Zlatareva-Petrova, Ani, Asselah, Jamil, Assi, Hazem, Brezden-Masley, Christine, Chia, Stephen, Freedman, Ori, Harb, Mohammed, Joy, Anil Abraham, Kulkarni, Swati, Prady, Catherine, Gaete, Alejandro Andres Acevedo, Matamala, Luis, Torres, Roberto, Yanez, Eduardo, Franco, Sandra, Urrego, Marcela, Gugić, Damir, Vrbanec, Damir, Melichar, Bohuslav, Prausová, Jana, Vyzula, Rostislav, Pilarte, Rafael Gutierrez, León, María Isabel, Muñoz, Rene, Ramos, Glenda, Azeem, Hamdy Abdel, Aziz, Amr Abdel, El Zawahry, Heba, Osegueda, Finlander Rosales, Alexandre, Jerome, Artignan, Xavier, Barletta, Hugues, Beguier, Emmanuel, Berdah, Jean-François, Marty, Chantal Bernard, Bollet, Marc, Bourgeois, Hugues, Bressac, Claude, Burki, Franck, Campone, Mario, Coeffic, David, Cojocarasu, Oana Zveltlana, Dagada, Corinne, Dalenc, Florence, Del Piano, Francesco, Desauw, Christophe, Desmoulins, Isabelle, Dohollou, Nadine, Egreteau, Joelle, Ferrero, Jean-Marc, Foa, Cyril, Garidi, Reda, Gasnault, Laurent, Gligorov, Joseph, Guardiola, Emmanuel, Hamizi, Salima, Jarcau, Rosana, Jacquin, Jean-Philippe, Jaubert, Dominique, Jolimoy, Geneviève, Mineur, Hortense Laharie, Largillier, Remy, Leduc, Bernard, Martin, Philippe, Melis, Adrien, Monge, Jeremy, Moullet, Isabelle, Mousseau, Mireille, Nguyen, Suzanne, Orfeuvre, Hubert, Petit, Thierry, Pivot, Xavier, Priou, Frank, Bach, Isabelle Sillet, Simon, Helene, Stefani, Laetitia, Uwer, Lionel, Youssef, Ali, Aktas, Bahriye, von der Assen, Albert, Augustin, Doris, Balser, Christina, Bauer, Lelia-Eveline, Bechtner, Christina, Beyer, Greta, Brucker, Cosima, Bückner, Ute, Busch, Steffi, Christensen, Bernd, Deryal, Mustafa, Farrokh, Andre, Faust, Elke, Friedrichs, Kay, Graf, Heiko, Griesshammer, Martin, Grischke, Eva-Maria, Hänle, Claudia, Heider, Andrea, Henschen, Stephan, Hesse, Tobias, Jackisch, Christian, Kisro, Jens, Köhler, Andreas, Kuemmel, Sherko, Lampe, Dieter, Lantzsch, Tilmann, Latos, Kunibert, Lex, Benno, Liedtke, Cornelia, Luedders, Doerte, Maintz, Christoph, Müller, Volkmar, Overkamp, Friedrich, Park-Simon, Tjoung-won, Paul, Marion, Prechtl, Anita, Ringsdorf, Uta, Runnebaum, Ingo, Ruth, Sylvia, Salat, Christoph, Scheffen, Iris, Schilling, Jörg, Schmatloch, Sabine, Schmidt, Marcus, Schneeweiss, Andreas, Schrader, Iris, Seipelt, Gernot, Simon, Elke, Stefek, Andrea, Stickeler, Elmar, Thill, Marc, Tio, Joke, Tuczek, Anna, Warm, Mathias, Weigel, Michael, Wischnik, Arthur, Wojcinski, Sebastian, Ziegler-Löhr, Katja, Aravantinos, Gerasimos, Ardavanis, Alexandros, Fountzilas, George, Gogas, Helen, Kakolyris, Stylianos, Mavroudis, Dimitris, Papadimitriou, Christos, Papandreou, Christos, Papazisis, Konstantinos, Castro, Hugo, Hernandez-Monroy, Cesar Estuardo, Ngan, Roger, Yeo, Winnie, Bittner, Nora, Boer, Katalin, Csejtei, Andras, Horvath, Zsolt, Kocsis, Judit, Mangel, László Csaba, Mezei, Klara, Nagy, Zsuzsanna, Szanto, Janos, Atmakusuma, Djumhana, Fadjari, Heri, Kurnianda, Djohan, Prayogo, Nugroho, Tanggo, Eddie Herman, Coate, Linda, Hennessy, Bryan, Kelly, Cathy, Martin, Michael, Nasim, Saira, O'Connor, Miriam, Aieta, Michele, Allegrini, Giacomo, Amadori, Dino, Bidoli, Paolo, Biti, Giampaolo, Bordonaro, Roberto, Bottini, Alberto, Carterni, Giacomo, Cavanna, Luigi, Cazzaniga, Marina, Cognetti, Francesco, Contu, Antonio, Cruciani, Giorgio, Donadio, Michela, Falcone, Alfredo, Farci, Daniele, Forcignanò, R. Chiara, Frassoldati, Antonio, Gaion, Fernando, Gamucci, Teresa, Giotta, Francesco, de Laurentiis, Michele, Livi, Lorenzo, Lorusso, Vito, Maiello, Evaristo, Marchetti, Paolo, Mariani, Gabriella, Mion, Marta, Moscetti, Luca, Musolino, Antonino, Pazzola, Antonio, Pedrazzoli, Paolo, Pigi, Andrea, de Placido, Sabino, Caremoli, Elena Rota, Santoro, Armando, Tienghi, Amelia, Ahn, Jin-Seok, Jung, Kyung Hae, Lee, Keun Seok, Lee, Soo Hyeon, Seo, Jae Hong, Sohn, Joo-Hyuk, Cesas, Alvydas, Juozaityte, Elona, Cheah, Nellie Lay Chin, Chong, Flora Li Tze, Devi, Beena C.R., Phua, Vincent, Teoh, Darren, Ching, Lee Wei, Yusof, Mastura, Corona, Jorge, Dominguez, Adriana, Mendoza, René Lazaro González, Hernandez, Carlos Alberto, Ramiro, Alejandro Juarez, Santos, Juan Matos, Espinosa, Paola Morales, Villarreal Garza, Cynthia Mayte, Errihani, Hassan, Bakker, Sandra, van den Berkmortel, Franchette, Blaisse, R.J.B., Huinink, Daan ten Bokkel, van den Bosch, J., Braun, J.J., Dercksen, M.W., Droogendijk, Helga, Erdkamp, Frans, Haringhuizen, Annebeth, de Jongh, F.E., Kok, T.C., Los, Maartje, Madretsma, Stanley, Terwogt, Jetske M. Meerum, van der Padt, Annemieke, van Rossum-Schornagel, Quirine Clementine, Smilde, T.J., de Valk, Bart, van der Velden, Annette, van Warmerdam, Laurence, van de Wouw, A.J., North, Richard, Kersten, Christian, Mjaaland, Ingvild, Wist, Erik, Aziz, Zeba, Masood, Nehal, Rashid, Kamran, Shah, Mazhar, Alcedo, Juan Carlos, Aleman, Diana, Neciosup, Silvia, Reategui, Rocio, Valdiviezo, Natalia, Vera, Luis, Fernando, Gracieux, Roque, Fernando, Strebel, Heinrik Martin, Krzemieniecki, Krzysztof, Litwiniuk, Maria, Mruk, Andrzej, Pienkowski, Tadeusz, Sawrycki, Piotr, Slomian, Grzegorz, Tomczak, Piotr, Afonso, Noemia, Cardoso, Fátima, Damasceno, Margarida, Nave, Monica, Badulescu, Florinel, Ciule, Larisa, Curescu, Stefan, Eniu, Alexandru, Filip, Dumitru, Grecea, Daniela, Jinga, Dan-Corneliu, Lungulescu, Dan, Oprean, Cristina Marinela, Stanculeanu, Dana Lucia, Turdean, Maria, Dvornichenko, Viktoria, Emelyanov, Sergey, Lichinitser, Mikhail, Manikhas, Alexey, Sakaeva, Dina, Shirinkin, Vadim, Stroyakovskiy, Daniil, Abulkhair, Omalkhair, Zekri, Jamal, Filipovic, Sladjana, Kovcin, Vladimir, Nedovic, Jasmina, Pesic, Jasna, Vasovic, Suzana, Ng, Raymond, Bystricky, Branislav, Leskova, Jaroslava, Mardiak, Jozef, Mišurová, Etela, Wagnerova, Maria, Takač, Iztok, Demetriou, Georgia Savva, Dreosti, Lydia, Govender, Poovandren, Jordaan, Johannes Petrus, Veersamy, Petrosian, Romero, Jose Luis Alonso, Lopez, Norberto Batista, Arias, Carmen Cañabate, Chacon, Jose, Aramburo, Antonio Fernandez, Morales, Luis Antonio Fernandez, Garcia, Mirta, Estevez, Laura Garcia, Garcia-Palomo Perez, Andres, Garcia Saenz, Jose Angel, Garcia Sanchis, Laura, Cubells, Laia Garrigos, Cortijo, Lucia Gonzalez, Santiago, Santiago Gonzalez, De Aranguiz, Blanca Hernando Fernandez, Mañas, José Juan Illarramendi, Gallego, Pedro Jimenez, Cussac, Antonio Llombart, Ferrandiz, Cristina Llorca, Garrido, Maria Lomas, Alvarez, Pilar Lopez, Vega, Jose Manuel Lopez, Del Prado, Purificacion Martinez, Jañez, Noelia Martinez, Murillo, Serafin Morales, Rosales, Adolfo Murias, Jaso, Laura Murillo, Fernandez, Ignacio Pelaez, Martorell, Antonia Perello, Carrion, Ramon Perez, Simon, Sonia Pernas, Alcibar, Arrate Plazaola, Lorenzo, Jose Ponce, Garcia, Vanesa Quiroga, Asensio, Teresa Ramon y Cajal, Maicas, Maria Dolores Torregrosa, Villanueva Silva, Maria Jose, Killander, Fredrika, Svensson, Jan Henry, Fehr, Mathias, Hauser, Nik, Müller, Andreas, Pagani, Olivia, Passmann-Kegel, Heike, Popescu, Razvan, Rabaglio, Manuela, Rauch, Daniel, Schlatter, Christina, Zaman, Khalil, Chang, Tsai-Wang, Huang, Chiun-Sheng, Wang, Hwei-Chung, Yu, Jyh-Cherng, Bandidwattanawong, Chanyoot, Maneechavakajorn, Jedzada, Seetalarom, Kasan, Dejthevaporn, Thitiya (Sirisinha), Somwangprasert, Areewan, Vongsaisuwon, Mawin, Akbulut, Hakan, Altundag, Kadri, Arican, Ali, Bozcuk, Hakan, Eralp, Yesim, Idris, Mohamed, Isikdogan, Abdurrahman, Senol, Coskun Hasan, Sevinc, Alper, Uygun, Kazim, Yucel, Eftal, Yucel, Idris, Yumuk, Fulden, Shparyk, Yaroslav, Voitko, Nataliia, Jaloudi, Mohammed, Adams, Jocelyn, Agrawal, Rajiv, Ahmed, Samreen, Alhasso, Abdulla, Allerton, Rozenn, Anwar, Suhail, Archer, Caroline, Ashford, Richard, Barraclough, Lisa, Bertelli, Gianfilippo, Bishop, Jill, Branson, Tony, Butt, Mohammed, Chakrabarti, Amit, Chakraborti, Prabir, Churn, Mark, Crowley, Clare, Davis, Ruth, Dhadda, Amandeep, Eldeeb, Hany, Fraser, Judith, Hall, Julia, Hickish, Tamas, Hogg, Martin, Howe, Theresa, Joffe, Jonathan, Kelleher, Muireann, Kelly, Stephen, Kendall, Anne, Kristeleit, Hartmut, Lumsden, Graeme, Macmillan, Craig, MacPherson, Iain, Malik, Zafar, Mithal, Natasha, Neal, Anthony, Panwar, Udaiveer, Proctor, Andrew, Proctor, Steven John, Raj, Sanjay, Rehman, Shazza, Sandri, Ines, Scatchard, Kate, Sherwin, Elizabeth, Sims, Eliot, Singer, Julian, Smith, Sarah, Tahir, Saad, Taylor, Wendy, Tsalic, Medy, Verrill, Mark, Wardley, Andrew, Waters, Simon, Wheatley, Duncan, Wright, Kathryn, Yuille, Frances, Alonso, Isabel, Artagaveytia, Nora, Rodriguez, Robinson, Arbona, Esther, Garcia, Yuraima, Lion, Lorena, Marcano, Dalila, Van Thuan, Tran, Gligorov, J., Ataseven, B., Verrill, M., De Laurentiis, M., Jung, K.H., Azim, H.A., Al-Sakaff, N., Lauer, S., Shing, M., and Pivot, X.

Published
2017
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18. Patients' preferences for subcutaneous trastuzumab versus conventional intravenous infusion for the adjuvant treatment of HER2-positive early breast cancer: final analysis of 488 patients in the international, randomized, two-cohort PrefHer study

Author

Fallowfield, Lesley, Jenkins, Valerie, Kilkerr, Justine, Langridge, Carolyn, Monson, Kathryn, Jakobsen, Erik Hugger, Nielsen, Mette Holck, Linnet, Soeren, Knoop, Ann, Pivot, Xavier, Bonnefoi, Herve, Mousseau, Mireille, Zelek, Laurent, Bourgeois, Hugues, Lefeuvre, Claudia Plesse, Bachelot, Thomas, Petit, Thierry, Brain, Etienne, Levy, Christelle, Gligorov, Joseph, Augustin, Doris, Graf, Heiko, Heinrich, Georg, Kroening, Hendrik, Kuemmel, Sherko, Müller, Volkmar, Overkamp, Friedrich, Park-Simon, Tjoung-Won, Schmidt, Marcus, Perlova-Griff, Lidia, Wolf, Christopher, Colleoni, Marco, Ballestrero, Alberto, Bernardo, Antonio, Ribecco, Angela Stefania, Gianni, Luca, Curigliano, Giuseppe, Brewczynska, Elżbieta, Jassem, Jacek, Shirinkin, Vadim, Manikhas, Alexey, Dvornichenko, Victoria, Lichinitser, Mikhail, Semiglazov, Vladimir, Mukhametshina, Guzel, Bulavina, Irina, Arranz, Enrique Espinosa, Ocon, Francisco Carabantes, Vivanco, Guillermo López, Bofill, Javier Salvador, Quintela, Ignacio Porras, Muñoz, Alfonso Sanchez, Pérez, Yolanda Fernández, Espinosa, Javier Cassinello, Alvarez, José Valero, del Prado, Rodrigo Lastra, De Merino, LuisLa Cruz, García, José Manuel Pérez, Frances, Santos Enrech, Edlund, Per, Norberg, Bengt, Wennstig, Anna-Karin, Lind, Pehr, Hauser, Nik, Tausch, Christoph, Camci, Celalettin, Arpaci, Fikret, Abali, Huseyin, Uslu, Ruchan, Tahir, Saad, Wheatley, Duncan, Chan, Stephen, Barrett-Lee, Peter, McAdam, Karen, Simcock, Richard, Burcombe, Russell, El-Maraghi, Robert, Califaretti, Nadia, Spadafora, Silvana, Sehdev, Sandeep, Sami, Amer, Verma, Sunil, Pivot, X., Gligorov, J., Müller, V., Curigliano, G., Knoop, A., Verma, S., Jenkins, V., Scotto, N., Osborne, S., and Fallowfield, L.

Published
2014
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21. Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis

Author

Saberi, Amin, Ebneabbasi, Amir, Rahimi, Sama, Sarebannejad, Sara, Sen, Zumrut Duygu, Graf, Heiko, Walter, Martin, Sorg, Christian, Camilleri, Julia A., Laird, Angela R., Fox, Peter T., Valk, Sofie L., Eickhoff, Simon B., and Tahmasian, Masoud

Abstract

Background: Neuroimaging studies have provided valuable insights into the macroscale impacts of antidepressants on brain functions in patients with major depressive disorder. However, the findings of individual studies are inconsistent. Here, we aimed to provide a quantitative synthesis of the literature to identify convergence of the reported findings at both regional and network levels and to examine their associations with neurotransmitter systems. Methods: Through a comprehensive search in PubMed and Scopus databases, we reviewed 5258 abstracts and identified 36 eligible functional neuroimaging studies on antidepressant effects in major depressive disorder. Activation likelihood estimation was used to investigate regional convergence of the reported foci of antidepressant effects, followed by functional decoding and connectivity mapping of the convergent clusters. Additionally, utilizing group-averaged data from the Human Connectome Project, we assessed convergent resting-state functional connectivity patterns of the reported foci. Next, we compared the convergent circuit with the circuits targeted by transcranial magnetic stimulation therapy. Last, we studied the association of regional and network-level convergence maps with selected neurotransmitter receptors/transporters maps. Results: No regional convergence was found across foci of treatment-associated alterations in functional imaging. Subgroup analysis in the Treated > Untreated contrast revealed a convergent cluster in the left dorsolateral prefrontal cortex, which was associated with working memory and attention behavioral domains. Moreover, we found network-level convergence of the treatment-associated alterations in a circuit more prominent in the frontoparietal areas. This circuit was co-aligned with circuits targeted by “anti-subgenual” and “Beam F3” transcranial magnetic stimulation therapy. We observed no significant correlations between our meta-analytic findings with the maps of neurotransmitter receptors/transporters. Conclusion: Our findings highlight the importance of the frontoparietal network and the left dorsolateral prefrontal cortex in the therapeutic effects of antidepressants, which may relate to their role in improving executive functions and emotional processing.

Published
2024
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22. The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review.

Author

Elsayed, Mohamed, Dardeer, Khaled T., Khehra, Nimrat, Padda, Inderbir, Graf, Heiko, Soliman, Amr, Makram, Abdelrahman M., Zeiss, René, and Schönfeldt-Lecuona, Carlos

Subjects
LEVONORGESTREL intrauterine contraceptives, INTRAUTERINE contraceptives, MENTAL illness, MENTAL depression, SUICIDE risk factors, SYMPTOMS
Abstract

Levonorgestrel (LNG)-intrauterine devices (IUDs) are an effective method of contraception; however, there is growing evidence regarding potential psychiatric side effects such as depressive symptoms, anxiety, and suicidal thoughts. Therefore, we conducted this systematic review to summarise the psychiatric effects of using LNG-IUDs. We searched six databases (MEDLINE, Web of Science, Scopus, Science Direct, Cochrane Library, and PsycInfo), and we included all study designs. The included studies were extracted, quality assessed, and qualitatively summarised. Out of the screened studies, only 22 were finally included. While ten studies showed increased depressive symptoms, two studies showed reduced symptoms. Moreover, one study showed increased anxiety, another one reported an increased risk of suicide, four studies concluded no association with depressive symptoms, and four other studies showed uncertainty about a potential association but mentioned other psychiatric symptoms. Despite unreliable data, many studies report psychiatric symptoms associated with LNG-IUDs, predominantly depression. Gynaecologists, general practitioners, and psychiatrists should therefore be aware of these potential risks, especially depressive symptoms and suicidality. Counselling patients about these risks should be mandatory. Further studies should investigate the absolute risk of mental disorders associated with LNG-IUDs and other hormonal contraceptives. Many researchers are reporting adverse psychiatric events associated with levonorgestrel intrauterine devices (LNG-IUDs). Despite their effectiveness, a proper psychiatric assessment should be done before inserting LNG-IUDs. Proper counselling regarding the depressive symptoms and suicidality should be done by the treating obstetrician. Further studies should investigate the absolute risk of mental disorders associated with LNG-IUDs and other hormonal contraceptives. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin

Author

Healy, David, primary, Bahrick, Audrey, additional, Bak, Maarten, additional, Barbato, Angelo, additional, Calabrò, Rocco Salvatore, additional, Chubak, Barbara M., additional, Cosci, Fiammetta, additional, Csoka, Antonei B., additional, D’Avanzo, Barbara, additional, Diviccaro, Silvia, additional, Giatti, Silvia, additional, Goldstein, Irwin, additional, Graf, Heiko, additional, Hellstrom, Wayne J.G., additional, Irwig, Michael S., additional, Jannini, Emmanuele A., additional, Janssen, Paddy K.C., additional, Khera, Mohit, additional, Kumar, Manoj Therayil, additional, Le Noury, Joanna, additional, Lew-Starowicz, Michał, additional, Linden, David E.J., additional, Lüning, Celine, additional, Mangin, Dee, additional, Melcangi, Roberto Cosimo, additional, Rodríguez, Omar Walid Muquebil Ali Al Shaban, additional, Panicker, Jalesh N., additional, Patacchini, Arianna, additional, Pearlman, Amy M., additional, Pukall, Caroline F., additional, Raj, Sanjana, additional, Reisman, Yacov, additional, Rubin, Rachel S., additional, Schreiber, Rudy, additional, Shipko, Stuart, additional, Vašečková, Barbora, additional, and Waraich, Ahad, additional

Published
2022
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33. Quality of Life in SMA Patients Under Treatment With Nusinersen

Author

Mix, Lucas, Winter, Benedikt, Wurster, Claudia, Platen, Sophia, Witzel, Simon, Uzelac, Zeljko, Graf, Heiko, Ludolph, Albert C, and Lulé, Dorothée

Subjects
antisense oligonucleotide, Quality of life, Muscular atrophy, Spinal, Well-being, Brief Research Report, Oligonucleotides, Antisense, Patient reported outcome, Neurology, Spinale Muskelatrophie, Oligonucleotide, nusinersen (Spinraza), ddc:610, Rusinersen (Spinraza), DDC 610 / Medicine & health, Depressiveness, spinal muscular atrophy, Lebensqualität
Abstract

Background: Spinal Muscular Atrophy (SMA) is a severe neurodegenerative disease, characterized by progressive muscle weakness and atrophy. The approval of the antisense oligonucleotide (ASO) nusinersen now provides an effective pharmacological approach with the potential to slow down or stop disease progression with a potentially major impact on patients' well-being. Objective: This study evaluates quality of life (QoL) in pediatric and adult patients over the course of therapy with nusinersen. Methods: Twenty-six SMA patients treated with nusinersen were evaluated regarding global QoL (gQoL), health-related QoL (HRQoL) and depressiveness. Assessments were conducted three times over the first 6 months of treatment. Applied were different questionnaires: the Anamnestic Comparative Self-Assessment (ACSA) for gQoL, the Short Form-36 Health Survey (SF-36) for HRQoL in adult patients and the ALS Depression Inventory 12 Items (ADI-12) for depressiveness. The sample was matched with 22 healthy controls. Results: Despite severe physical restrictions, patients reported high levels of QoL and low levels of depressiveness at study entry. Early disease onset and low levels of physical functioning were associated with better gQoL and lower levels of depressiveness. A significant decrease of gQoL in patients was evident over the course of the study. Still, adult patients reported a significant increase in perceived health. Conclusions: Our study provides first insight that SMA patients experience a gQoL superior to healthy controls at start of therapy. This might indicate patients' high hopes and expectations toward treatment. gQoL returns to a level similar to that of healthy controls over the course of therapy., publishedVersion

Published
2021
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34. Patientsʼ preferences for subcutaneous trastuzumab versus conventional intravenous infusion for the adjuvant treatment of HER2-positive early breast cancer: final analysis of 488 patients in the international, randomized, two-cohort PrefHer study

Author

Pivot, X., Gligorov, J., Müller, V., Curigliano, G., Knoop, A., Verma, S., Jenkins, V., Scotto, N., Osborne, S., Fallowfield, L., Fallowfield, Lesley, Jenkins, Valerie, Kilkerr, Justine, Langridge, Carolyn, Monson, Kathryn, Jakobsen, Erik Hugger, Nielsen, Mette Holck, Linnet, Soeren, Knoop, Ann, Pivot, Xavier, Bonnefoi, Herve, Mousseau, Mireille, Zelek, Laurent, Bourgeois, Hugues, Lefeuvre, Claudia Plesse, Bachelot, Thomas, Petit, Thierry, Brain, Etienne, Levy, Christelle, Gligorov, Joseph, Augustin, Doris, Graf, Heiko, Heinrich, Georg, Kroening, Hendrik, Kuemmel, Sherko, Müller, Volkmar, Overkamp, Friedrich, Park-Simon, Tjoung-Won, Schmidt, Marcus, Perlova-Griff, Lidia, Wolf, Christopher, Colleoni, Marco, Ballestrero, Alberto, Bernardo, Antonio, Ribecco, Angela Stefania, Gianni, Luca, Curigliano, Giuseppe, Brewczynska, Elżbieta, Jassem, Jacek, Shirinkin, Vadim, Manikhas, Alexey, Dvornichenko, Victoria, Lichinitser, Mikhail, Semiglazov, Vladimir, Mukhametshina, Guzel, Bulavina, Irina, Arranz, Enrique Espinosa, Ocon, Francisco Carabantes, Vivanco, Guillermo López, Bofill, Javier Salvador, Quintela, Ignacio Porras, Muñoz, Alfonso Sanchez, Pérez, Yolanda Fernández, Espinosa, Javier Cassinello, Alvarez, José Valero, del Prado, Rodrigo Lastra, Merino, Luis De La Cruz, García, José Manuel Pérez, Frances, Santos Enrech, Edlund, Per, Norberg, Bengt, Wennstig, Anna-Karin, Lind, Pehr, Hauser, Nik, Tausch, Christoph, Camci, Celalettin, Arpaci, Fikret, Abali, Huseyin, Uslu, Ruchan, Tahir, Saad, Wheatley, Duncan, Chan, Stephen, Barrett-Lee, Peter, McAdam, Karen, Simcock, Richard, Burcombe, Russell, El-Maraghi, Robert, Califaretti, Nadia, Spadafora, Silvana, Sehdev, Sandeep, Sami, Amer, and Verma, Sunil

Published
2014
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35. Depressive Disorder With Panic Attacks After Replacement of an Intrauterine Device Containing Levonorgestrel: A Case Report

Author

Zeiss, René, Schönfeldt Lecuona, Carlos José, Gahr, Maximilian, and Graf, Heiko

Subjects
Psychiatry, endocrine system, levonorgestrel, Depression, lcsh:RC435-571, Levonorgestrel, Anxiety, Empfängnisverhütungsmittel, intrauterine device, anxiety, Contraception, lcsh:Psychiatry, Intrauterine devices, depression, case report, ddc:610, Arzneimittelnebenwirkung, Intrauterinpessar
Abstract

The levonorgestrel-releasing intrauterine system (LNG-IUS) is used as hormonal contraception by millions of women worldwide. It is considered as a safe device with low rates of systemic adverse drug reactions (ADRs). However, an emerging evidence suggest mood changes as ADRs. Whereas most of these studies report psychiatric ADRs after the first implantation of the LNG-IUS, it has to be considered that these may also occur after replacement, even when psychiatric symptoms were not evident at the time of the initial insertion. A potential explanation for the development of psychiatric ADRs in subsequent LNG-IUS may rely on fluctuations of sex hormones throughout the female life cycle with changing windows of vulnerabilities for developing mood disorders. Thus, the reliable contraception for women remains a continual challenge. We present the case of a 41-year-old woman that used the LNG-IUS (Mirena®) for contraception over 5 years without any complaints. Within the first weeks after insertion of the second LNG-IUS, she developed a depressive syndrome and anxieties. An extensive somatic, including gynecological examination revealed no pathological findings and a mental disorder was suggested. Due to the patient´s request and the recommendation of her psychiatrist, the device was removed and led to a remission of her mental complaints up to a 6- and 12-months follow-up. Beyond the mood changes considerably affecting her quality of life, the patient raised the concerns that she has never been informed about potential ADRs on mental health and her remarks regarding the potential association between psychiatric symptoms and the LNG-IUS were considered as groundless. With this case, we strengthen previous observations regarding mood changes under LNG-IUS. Moreover, we illustrate that psychiatric symptoms may also occur as ADRs during the subsequent insertion. Thus, we emphasize that psychiatric symptoms have to be clearly communicated as ADRs to patients with LNG-IUS within a written informed consent and should be routinely examined by gynecologists.

Published
2020
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41. Emotional components of pain perception in borderline personality disorder and major depression : a repetitive Peripheral Magnetic Stimulation (rPMS) study

Author

Malejko, Kathrin, Huss, André Michael, Schönfeldt Lecuona, Carlos José, Braun, Maren Sophie, and Graf, Heiko

Subjects
Borderline personality disorder, Depression, mental disorders, Pain, Borderline-Persönlichkeitsstörung, ddc:610, repetitive peripheral magnetic stimulation, rPMS, Schmerz, behavioral disciplines and activities, DDC 610 / Medicine & health, Magnetische Stimulation
Abstract

Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus intensities using repetitive peripheral magnetic stimulation (rPMS) and observed alterations in emotional rather than somatosensory components in BPD. However, conclusions on disorder specific alterations in these components of pain perception are often limited due to comorbid depression and medication in BPD. Here, we compared 10 patients with BPD and comorbid MD, 12 patients with MD without BPD, and 12 HC. We applied unpleasant somatosensory stimuli with increasing intensities by rPMS and assessed pain threshold (PT), cutaneous sensation, emotional valence, and arousal by a Self-Assessments Manikins scale. PTs in BPD were significantly higher compared to HC. The somatosensory discrimination of stimulus intensities did not differ between groups. Though elevated rPMS intensities led to increased subjective aversion and arousal in MD and HC, these emotional responses among intensity levels remained unchanged in BPD. Our data give further evidence for disorder-specific alterations in emotional components of pain perception in BPD with an absent emotional modulation among varying aversive intensity levels, publishedVersion

Published
2020
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42. Complementary and alternative medicine and musculoskeletal pain in the first year of adjuvant aromatase inhibitor treatment in early breast cancer patients

Author

Hack, Carolin C., Häberle, Lothar, Brucker, Sara Y., Janni, Wolfgang J., Volz, Bernhard, Loehberg, Christian R., Hartkopf, Andreas Daniel, Walter, Christina-Barbara, Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Lux, Michael P., Bayer, Christian Michael, Rauh, Claudia, Almstedt, Katrin, Gaß, Paul, Heindl, Felix, Brodkorb, Tobias Franz, Willer, L., Lindner, C., Kolberg, Hans Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Rack, Brigitte K., Beckmann, Matthias Wilhelm, Fehm, Tanja Natascha, Rody, Achim R., Maass, Nicolai, Hein, Alexander, Fasching, Peter Andreas, and Nabieva, Naiba

Subjects
Complementary Therapies, Aromatase Inhibitors, Medizin, Breast Neoplasms, Myalgia, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Arthralgia, Postmenopause, Breast cancer, Complementary and alternative medicine, Medizinische Fakultät, Musculoskeletal Pain, Germany, Letrozole, Humans, Female, Original Article, ddc:610, Integrative medicine, Endocrine therapy/treatment, Aged
Abstract

Background Patients with breast cancer (BC) show strong interest in complementary and alternative medicine (CAM), particularly for adverse effects of adjuvant endocrine treatment — e.g., with letrozole. Letrozole often induces myalgia/limb pain and arthralgia, with potential noncompliance and treatment termination. This analysis investigated whether CAM before aromatase inhibitor (AI) therapy is associated with pain development and the intensity of AI-induced musculoskeletal syndrome (AIMSS) during the first year of treatment. Patients and methods The multicenter phase IV PreFace study evaluated letrozole therapy in postmenopausal, hormone receptor–positive patients with early BC. Patients were asked about CAM use before, 6 months after, and 12 months after treatment started. They recorded pain every month for 1 year in a diary including questions about pain and numeric pain rating scales. Data were analyzed for patients who provided pain information for all time points. Results Of 1396 patients included, 901 (64.5%) had used CAM before AI treatment. Throughout the observation period, patients with CAM before AI treatment had higher pain values, for both myalgia/limb pain and arthralgia, than non-users. Pain increased significantly in both groups over time, with the largest increase during the first 6 months. No significant difference of pain increase was noted regarding CAM use. Conclusions CAM use does not prevent or improve the development of AIMSS. Pain intensity was generally greater in the CAM group. Therefore, because of the risk of non-compliance and treatment discontinuation due to the development of higher pain levels, special attention must be paid to patient education and aftercare in these patients., Highlights • Pain levels of myalgia/limb pain and arthralgia increase under letrozole intake. • Within one year pain levels increase in both, CAM users as well as non-CAM users. • In CAM users pain levels were higher at all time points than in non-CAM users. • The greatest increase of pain levels was noted in the first six treatment months. • CAM does not prevent or improve the development of myalgia/limb pain and arthralgia.

Published
2020

43. Somatosensory stimulus intensity encoding in borderline personality disorder

Author

Malejko, Kathrin, Neff, Dominik, Brown, Rebecca Corinna, Plener, Paul L., Bonenberger, Martina, Abler, Birgit, Grön, Georg, and Graf, Heiko

Subjects
Magnetic resonance imaging, ddc:150, stimulus processing, Borderline personality disorder, Funktionelle Kernspintomografie, borderline, fMRI, pain, Borderline-Persönlichkeitsstörung, parametric
Published
2018

44. Differential noradrenergic modulation of monetary reward and visual erotic stimulus processing

Author

Graf, Heiko, Wiegers, Maike, Metzger, Coraline D., Walter, Martin, and Abler, Birgit

Subjects
Psychiatry, Psychotropic drugs, reboxetine, fMRI, healthy, Amisulprid, Reboxetin, Psychiatry and Mental health, amisulpride, Magnetic resonance imaging, Psychopharmakon, primary reward, Funktionelle Kernspintomografie, money, ddc:610, secondary reward, psychological phenomena and processes, erotic, Original Research
Abstract

We recently investigated the effects of the noradrenergic antidepressant reboxetine and the antipsychotic amisulpride compared to placebo on neural correlates of primary reinforcers by visual erotic stimulation in healthy subjects. Whereas, amisulpride left subjective sexual functions and corresponding neural activations unimpaired, attenuated neural activations were observed under reboxetine within the nucleus accumbens (Nacc) along with diminished behavioral sexual functioning. However, a global dampening of the reward system under reboxetine seemed not intuitive considering the complementary role of the noradrenergic to the dopamine system in reward-related learning mediated by prediction error processing. We therefore investigated the sample of 17 healthy males in a mean age of 23.8 years again by functional magnetic resonance imaging (fMRI), to explore the noradrenergic effects on neural reward prediction error signaling. Participants took reboxetine (4 mg/d), amisulpride (200 mg/d), and placebo each for 7 days within a randomized, double-blind, within-subject cross-over design. During fMRI, we used an established monetary incentive task to assess neural reward expectation and prediction error signals within the bilateral Nacc using an independent anatomical mask for a region of interest (ROI) analysis. Activations within the same ROI were also assessed for the erotic picture paradigm. We confirmed our previous results from the whole brain analysis for the selected ROI by significant (p < 0.05 FWE-corrected) attenuated activations within the Nacc during visual sexual stimulation under reboxetine compared to placebo. However, activations in the Nacc concerning prediction error processing and monetary reward expectation were unimpaired under reboxetine compared to placebo, along with unimpaired reaction times in the reward task. For both tasks, neural activations and behavioral processing were not altered by amisulpride compared to placebo. The observed attenuated neural activations within the Nacc during visual erotic stimulation along with unimpaired neural prediction error and monetary reward expectation processing provide evidence for a differential modulation of the neural reward system by the noradrenergic agent reboxetine depending on the presence of primary reinforcers such as erotic stimuli in contrast to secondary such as monetary rewards.

Published
2018
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45. Preexisting musculoskeletal burden and its development under letrozole treatment in early breast cancer patients

Author

Nabieva, Naiba, primary, Häberle, Lothar, additional, Brucker, Sara Y., additional, Janni, Wolfgang, additional, Volz, Bernhard, additional, Loehberg, Christian R., additional, Hartkopf, Andreas D., additional, Walter, Christina‐Barbara, additional, Baake, Gerold, additional, Fridman, Alexander, additional, Malter, Wolfram, additional, Wuerstlein, Rachel, additional, Harbeck, Nadia, additional, Hoffmann, Oliver, additional, Kuemmel, Sherko, additional, Martin, Bernhard, additional, Thomssen, Christoph, additional, Graf, Heiko, additional, Wolf, Christopher, additional, Lux, Michael P., additional, Bayer, Christian M., additional, Rauh, Claudia, additional, Hack, Carolin C., additional, Almstedt, Katrin, additional, Gass, Paul, additional, Heindl, Felix, additional, Brodkorb, Tobias, additional, Lindner, Christoph, additional, Kolberg, Hans‐Christian, additional, Krabisch, Petra, additional, Weigel, Michael, additional, Steinfeld‐Birg, Dieter, additional, Kohls, Andreas, additional, Brucker, Cosima, additional, Schulz, Volker, additional, Fischer, Gunnar, additional, Pelzer, Volker, additional, Rack, Brigitte, additional, Beckmann, Matthias W., additional, Fehm, Tanja, additional, Rody, Achim, additional, Maass, Nicolai, additional, Hein, Alexander, additional, and Fasching, Peter A., additional

Published
2019
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47. Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer

Author

Wunderle, Marius, Pretscher, Jutta, Brucker, Sara Y., Volz, Bernhard, Hartmann, Arndt, Fiessler, Cornelia, Hein, Alexander, Haeberle, Lothar, Jud, Sebastian M., Lux, Michael P., Janni, Wolfgang, Loehberg, Christian R., Hartkopf, Andreas D., Walter, Christina B., Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Bayer, Christian M., Hack, Carolin C., Almstedt, Katrin, Gass, Paul, Heindl, Felix, Brodkorb, Tobias F., Nabieva, Naiba, Lindner, Christoph, Kolberg, Hans-Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Wallwiener, Diethelm, Rack, Brigitte, Fehm, Tanja, Rody, Achim, Maass, Nicolai, Beckmann, Matthias W., Fasching, Peter A., Rauh, Claudia, Wunderle, Marius, Pretscher, Jutta, Brucker, Sara Y., Volz, Bernhard, Hartmann, Arndt, Fiessler, Cornelia, Hein, Alexander, Haeberle, Lothar, Jud, Sebastian M., Lux, Michael P., Janni, Wolfgang, Loehberg, Christian R., Hartkopf, Andreas D., Walter, Christina B., Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Bayer, Christian M., Hack, Carolin C., Almstedt, Katrin, Gass, Paul, Heindl, Felix, Brodkorb, Tobias F., Nabieva, Naiba, Lindner, Christoph, Kolberg, Hans-Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Wallwiener, Diethelm, Rack, Brigitte, Fehm, Tanja, Rody, Achim, Maass, Nicolai, Beckmann, Matthias W., Fasching, Peter A., and Rauh, Claudia

Abstract

PurposeEvidence shows that genetic and non-genetic risk factors for breast cancer (BC) differ relative to the molecular subtype. This analysis aimed to investigate associations between epidemiological risk factors and immunohistochemical subtypes in a cohort of postmenopausal, hormone receptor-positive BC patients.MethodsThe prospective, single-arm, multicenter phase IV PreFace study (Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy) included 3529 postmenopausal patients with hormone receptor-positive early BC. Data on their epidemiological risk factors were obtained from patients' diaries and their medical histories. Data on estrogen receptor, progesterone receptor, and HER2 receptor status were obtained from pathology reports. Patients with incomplete information were excluded. Data were analyzed using conditional inference regression analysis, analysis of variance, and the chi-squared test.ResultsIn a cohort of 3392 patients, the strongest association with the molecular subtypes of BC was found for hormone replacement therapy (HRT) before diagnosis of early BC. The analysis showed that patients who took HRT at diagnosis had luminal A-like BC more often (83.7%) than those who had never taken HRT or had stopped taking it (75.5%). Luminal B-like BC and HER2-positive BC were diagnosed more often in women who had never taken HRT or had stopped taking it (13.3% and 11.2%, respectively) than in women who were taking HRT at diagnosis of BC (8.3% and 8.0%, respectively).ConclusionsThis analysis shows an association between HRT and the distribution of molecular subtypes of BC. However, no associations between other factors (e.g., age at diagnosis, body mass index, smoking status, age at menopause, number of deliveries, age at first delivery, breastfeeding history, or family history) were noted.

Published
2019

48. Preexisting musculoskeletal burden and its development under letrozole treatment in early breast cancer patients

Author

Nabieva, Naiba, Haeberle, Lothar, Brucker, Sara Y., Janni, Wolfgang, Volz, Bernhard, Loehberg, Christian R., Hartkopf, Andreas D., Walter, Christina-Barbara, Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Lux, Michael P., Bayer, Christian M., Rauh, Claudia, Hack, Carotin C., Almstedt, Katrin, Gass, Paul, Heindl, Felix, Brodkorb, Tobias, Lindner, Christoph, Kolberg, Hans-Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Rack, Brigitte, Beckmann, Matthias W., Fehm, Tanja, Rody, Achim, Maass, Nicolai, Hein, Alexander, Fasching, Peter A., Nabieva, Naiba, Haeberle, Lothar, Brucker, Sara Y., Janni, Wolfgang, Volz, Bernhard, Loehberg, Christian R., Hartkopf, Andreas D., Walter, Christina-Barbara, Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Lux, Michael P., Bayer, Christian M., Rauh, Claudia, Hack, Carotin C., Almstedt, Katrin, Gass, Paul, Heindl, Felix, Brodkorb, Tobias, Lindner, Christoph, Kolberg, Hans-Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Rack, Brigitte, Beckmann, Matthias W., Fehm, Tanja, Rody, Achim, Maass, Nicolai, Hein, Alexander, and Fasching, Peter A.

Abstract

One of the most common adverse events (AEs) occurring during treatment with aromatase inhibitors (AIs) is musculoskeletal pain. The aim of our study was to analyze the influence of preexisting muscle/limb pain and joint pain on the development of AI-induced musculoskeletal AEs. Women eligible for upfront adjuvant endocrine therapy with letrozole were included in the PreFace study, a multicenter phase IV trial. During the first treatment year, they were asked to record musculoskeletal AEs monthly by answering questions regarding pain symptoms and rating the pain intensity on a numeric rating scale from 0 (no pain) to 10 (very strong pain). Pain values were compared using nonparametric statistical tests. Overall, 1,416 patients were evaluable. The average pain value over all time points in women with preexisting muscle/limb pain was 4.3 (median 4.3); in those without preexisting pain, it was 2.0 (median 1.7). In patients without preexisting muscle/limb pain, pain levels increased relatively strongly within the first 6 months (mean increase +0.9, p < 0.00001) in comparison with those with preexisting pain (mean increase +0.3, p < 0.001), resulting in a statistically significant difference (p < 0.00001) between the two groups. The development of joint pain was similar in the two groups. Women without preexisting muscle/limb pain or joint pain have the greatest increase in pain after the start of adjuvant AI therapy. Women with preexisting pain have significantly higher pain values. The main increase in pain values takes place during the first 6 months of treatment.

Published
2019

49. Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer

Author

Wunderle, Marius, primary, Pretscher, Jutta, additional, Brucker, Sara Y., additional, Volz, Bernhard, additional, Hartmann, Arndt, additional, Fiessler, Cornelia, additional, Hein, Alexander, additional, Häberle, Lothar, additional, Jud, Sebastian M., additional, Lux, Michael P., additional, Janni, Wolfgang, additional, Loehberg, Christian R., additional, Hartkopf, Andreas D., additional, Walter, Christina B., additional, Baake, Gerold, additional, Fridman, Alexander, additional, Malter, Wolfram, additional, Wuerstlein, Rachel, additional, Harbeck, Nadia, additional, Hoffmann, Oliver, additional, Kümmel, Sherko, additional, Martin, Bernhard, additional, Thomssen, Christoph, additional, Graf, Heiko, additional, Wolf, Christopher, additional, Bayer, Christian M., additional, Hack, Carolin C., additional, Almstedt, Katrin, additional, Gass, Paul, additional, Heindl, Felix, additional, Brodkorb, Tobias F., additional, Nabieva, Naiba, additional, Lindner, Christoph, additional, Kolberg, Hans-Christian, additional, Krabisch, Petra, additional, Weigel, Michael, additional, Steinfeld-Birg, Dieter, additional, Kohls, Andreas, additional, Brucker, Cosima, additional, Schulz, Volker, additional, Fischer, Gunnar, additional, Pelzer, Volker, additional, Wallwiener, Diethelm, additional, Rack, Brigitte, additional, Fehm, Tanja, additional, Rody, Achim, additional, Maass, Nicolai, additional, Beckmann, Matthias W., additional, Fasching, Peter A., additional, and Rauh, Claudia, additional

Published
2019
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