Clinical work with challenging, difficult, or dislikable clients can elicit negative experiences for professional counselors. Using quantitative content analysis methodology embedded in a cross‐sectional, correlational design, we examined the prevalence of challenging client presentations and their influence on latent counselor interpersonal stress profiles using a large sample (n = 1356). Challenging client presentations associated with client expectations and progress, therapy‐interfering behaviors, client traits and behaviors, and counselor concerns and experiences predicted counselor membership in Disconnected, Exasperated, Paralyzed, Anguished, and Distressed Counselor profiles in comparison to the Relaxed Counselor profile. Recommendations for strengthening clinical practice and counselor wellness when working with challenging, difficult, or dislikable clients are provided. [ABSTRACT FROM AUTHOR]