Search

Your search keyword '"Grandhi, Ramesh"' showing total 838 results
Start Over Author "Grandhi, Ramesh"
838 results on '"Grandhi, Ramesh"'

1. The Impact of Postprocedural Anticoagulant Use in Patients Undergoing Woven EndoBridge: A Multicenter Propensity Score-Matched Study

Author

Musmar, Basel, Salim, Hamza Adel, Roy, Joanna M., Adeeb, Nimer, Fuleihan, Antony A., Atallah, Elias, Sizdahkhani, Saman, Koduri, Sravanthi, Karadimas, Spyridon, Baba, Bachar El, Howard, Brian M., Grossberg, Jonathan A., Scott, Kyle W., Burkhardt, Jan-Karl, Srinivasan, Visish M., Erazu, Fernanda, Hanel, Ricardo A., Amllay, Abdelaziz, Matouk, Charles, MacNeil, Andrew, Chalouhi, Nohra, Gomez-Paz, Santiago, Grandhi, Ramesh, Jaikumar, Vinay, Levy, Elad, Siddiqui, Adnan, Klaiman, Max, Delgado, Josser, Hoffman, Haydn, Arthur, Adam, Hasan, David M., Notarianni, Christina, Cuellar, Hugo H., Guthikonda, Bharat, Morcos, Jacques, Tjoumakaris, Stavropoula I., Gooch, Michael Reid, Rosenwasser, Robert H., and Jabbour, Pascal

Published
2024
Full Text
View/download PDF

2. Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study.

Author

Yue, John, Lee, Young, Sun, Xiaoying, van Essen, Thomas, Elguindy, Mahmoud, Belton, Patrick, Pisică, Dana, Mikolic, Ana, Deng, Hansen, Kanter, John, McCrea, Michael, Bodien, Yelena, Satris, Gabriela, Wong, Justin, Ambati, Vardhaan, Grandhi, Ramesh, Puccio, Ava, Mukherjee, Pratik, Valadka, Alex, Tarapore, Phiroz, Huang, Michael, DiGiorgio, Anthony, Markowitz, Amy, Yuh, Esther, Okonkwo, David, Steyerberg, Ewout, Lingsma, Hester, Menon, David, Maas, Andrew, Jain, Sonia, and Manley, Geoffrey

Subjects
Glasgow Outcome Scale, clinical prediction rules, mortality, prognosis, statistical models, traumatic brain injury
Abstract

OBJECTIVE: The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticosteroid Randomization After Significant Head Injury (CRASH) prognostic models for mortality and outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT and CRASH model performances in a contemporary cohort of US patients. METHODS: The prospective 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study (enrollment years 2014-2018) enrolled subjects aged ≥ 17 years who presented to level I trauma centers and received head CT within 24 hours of TBI. Data were extracted from the subjects who met the model criteria (for IMPACT, Glasgow Coma Scale [GCS] score 3-12 with 6-month Glasgow Outcome Scale-Extended [GOSE] data [n = 441]; for CRASH, GCS score 3-14 with 2-week mortality data and 6-month GOSE data [n = 831]). Analyses were conducted in the overall cohort and stratified on the basis of TBI severity (severe/moderate/mild TBI defined as GCS score 3-8/9-12/13-14), age (17-64 years or ≥ 65 years), and the 5 top enrolling sites. Unfavorable outcome was defined as GOSE score 1-4. Original IMPACT and CRASH model coefficients were applied, and model performances were assessed by calibration (intercept [< 0 indicated overprediction; > 0 indicated underprediction] and slope) and discrimination (c-statistic). RESULTS: Overall, the IMPACT models overpredicted mortality (intercept -0.79 [95% CI -1.05 to -0.53], slope 1.37 [1.05-1.69]) and acceptably predicted unfavorable outcome (intercept 0.07 [-0.14 to 0.29], slope 1.19 [0.96-1.42]), with good discrimination (c-statistics 0.84 and 0.83, respectively). The CRASH models overpredicted mortality (intercept -1.06 [-1.36 to -0.75], slope 0.96 [0.79-1.14]) and unfavorable outcome (intercept -0.60 [-0.78 to -0.41], slope 1.20 [1.03-1.37]), with good discrimination (c-statistics 0.92 and 0.88, respectively). IMPACT overpredicted mortality and acceptably predicted unfavorable outcome in the severe and moderate TBI subgroups, with good discrimination (c-statistic ≥ 0.81). CRASH overpredicted mortality in the severe and moderate TBI subgroups and acceptably predicted mortality in the mild TBI subgroup, with good discrimination (c-statistic ≥ 0.86); unfavorable outcome was overpredicted in the severe and mild TBI subgroups with adequate discrimination (c-statistic ≥ 0.78), whereas calibration was nonlinear in the moderate TBI subgroup. In subjects ≥ 65 years of age, the models performed variably (IMPACT-mortality, intercept 0.28, slope 0.68, and c-statistic 0.68; CRASH-unfavorable outcome, intercept -0.97, slope 1.32, and c-statistic 0.88; nonlinear calibration for IMPACT-unfavorable outcome and CRASH-mortality). Model performance differences were observed across the top enrolling sites for mortality and unfavorable outcome. CONCLUSIONS: The IMPACT and CRASH models adequately discriminated mortality and unfavorable outcome. Observed overestimations of mortality and unfavorable outcome underscore the need to update prognostic models to incorporate contemporary changes in TBI management and case-mix. Investigations to elucidate the relationships between increased survival, outcome, treatment intensity, and site-specific practices will be relevant to improve models in specific TBI subpopulations (e.g., older adults), which may benefit from the inclusion of blood-based biomarkers, neuroimaging features, and treatment data.

Published
2024

3. Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study.

Author

Yue, John, Etemad, Leila, Elguindy, Mahmoud, van Essen, Thomas, Belton, Patrick, Nelson, Lindsay, McCrea, Michael, Vreeburg, Rick, Gotthardt, Christine, Tracey, Joye, Coskun, Bukre, Krishnan, Nishanth, Halabi, Cathra, Eagle, Shawn, Korley, Frederick, Robertson, Claudia, Duhaime, Ann-Christine, Satris, Gabriela, Tarapore, Phiroz, Huang, Michael, Madhok, Debbie, Giacino, Joseph, Mukherjee, Pratik, Yuh, Esther, Valadka, Alex, Puccio, Ava, Okonkwo, David, Sun, Xiaoying, Jain, Sonia, Manley, Geoffrey, DiGiorgio, Anthony, Badjatia, Neeraj, Barber, Jason, Bodien, Yelena, Fabian, Brian, Ferguson, Adam, Foreman, Brandon, Gardner, Raquel, Gopinath, Shankar, Grandhi, Ramesh, Russell Huie, J, Dirk Keene, C, Lingsma, Hester, MacDonald, Christine, Markowitz, Amy, Merchant, Randall, Ngwenya, Laura, Rodgers, Richard, Schneider, Andrea, Schnyer, David, Taylor, Sabrina, Temkin, Nancy, Torres-Espin, Abel, Vassar, Mary, Wang, Kevin, Wong, Justin, and Zafonte, Ross

Subjects
mortality, patient outcome assessment, risk factor, traumatic brain injury
Abstract

OBJECTIVES: An estimated 14-23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI (msTBI) is not well delineated. We examined the associations between prior TBI, in-hospital mortality, and outcomes up to 12 months after injury in a prospective US msTBI cohort. METHODS: Data from hospitalized subjects with Glasgow Coma Scale score of 3-12 were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (enrollment period: 2014-2019). Prior TBI with amnesia or alteration of consciousness was assessed using the Ohio State University TBI Identification Method. Competing risk regressions adjusting for age, sex, psychiatric history, cranial injury and extracranial injury severity examined the associations between prior TBI and in-hospital mortality, with hospital discharged alive as the competing risk. Adjusted HRs (aHR (95% CI)) were reported. Multivariable logistic regressions assessed the associations between prior TBI, mortality, and unfavorable outcome (Glasgow Outcome Scale-Extended score 1-3 (vs. 4-8)) at 3, 6, and 12 months after injury. RESULTS: Of 405 acute msTBI subjects, 21.5% had prior TBI, which was associated with male sex (87.4% vs. 77.0%, p=0.037) and psychiatric history (34.5% vs. 20.7%, p=0.010). In-hospital mortality was 10.1% (prior TBI: 17.2%, no prior TBI: 8.2%, p=0.025). Competing risk regressions indicated that prior TBI was associated with likelihood of in-hospital mortality (aHR=2.06 (1.01-4.22)), but not with hospital discharged alive. Prior TBI was not associated with mortality or unfavorable outcomes at 3, 6, and 12 months. CONCLUSIONS: After acute msTBI, prior TBI history is independently associated with in-hospital mortality but not with mortality or unfavorable outcomes within 12 months after injury. This selective association underscores the importance of collecting standardized prior TBI history data early after acute hospitalization to inform risk stratification. Prospective validation studies are needed. LEVEL OF EVIDENCE: IV. TRIAL REGISTRATION NUMBER: NCT02119182.

Published
2024

4. Association of Early Beta-Blocker Exposure and Functional Outcomes in Critically Ill Patients With Moderate to Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Author

Kelly-Hedrick, Margot, Liu, Sunny, Temkin, Nancy, Barber, Jason, Komisarow, Jordan, Ohnuma, Tetsu, Colton, Katharine, Treggiari, Miriam, Monson, Eric, Vavilala, Monica, Grandhi, Ramesh, Laskowitz, Daniel, Mathew, Joseph, Hernandez, Adrian, James, Michael, Raghunathan, Karthik, Goldstein, Ben, Markowitz, Amy, Krishnamoorthy, Vijay, and Manley, Geoff

Subjects
beta blocker, cardioselective, disability, functional, traumatic brain injury
Abstract

OBJECTIVES: We aimed to 1) describe patterns of beta-blocker utilization among critically ill patients following moderate-severe traumatic brain injury (TBI) and 2) examine the association of early beta-blocker exposure with functional and clinical outcomes following injury. DESIGN: Retrospective cohort study. SETTING: ICUs at 18 level I, U.S. trauma centers in the Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) study. PATIENTS: Greater than or equal to 17 years enrolled in the TRACK-TBI study with moderate-severe TBI (Glasgow Coma Scale of

Published
2023

7. Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study

Author

Yue, John K, Kobeissy, Firas H, Jain, Sonia, Sun, Xiaoying, Phelps, Ryan RL, Korley, Frederick K, Gardner, Raquel C, Ferguson, Adam R, Huie, J Russell, Schneider, Andrea LC, Yang, Zhihui, Xu, Haiyan, Lynch, Cillian E, Deng, Hansen, Rabinowitz, Miri, Vassar, Mary J, Taylor, Sabrina R, Mukherjee, Pratik, Yuh, Esther L, Markowitz, Amy J, Puccio, Ava M, Okonkwo, David O, Diaz-Arrastia, Ramon, Manley, Geoffrey T, Wang, Kevin KW, Badjatia, Neeraj, Foreman, Brandon, Gopinath, Shankar, Grandhi, Ramesh, Jha, Ruchira M, Lingsma, Hester F, Madden, Christopher, Madhok, Debbie Y, McCrea, Michael A, Merchant, Randall, Nelson, Lindsay D, Ngwenya, Laura B, Robertson, Claudia S, Rodgers, Richard B, Satris, Gabriela G, Schnyer, David M, Valadka, Alex B, van Essen, Thomas A, and Zafonte, Ross

Subjects
Clinical Research, Brain Disorders, Traumatic Brain Injury (TBI), Traumatic Head and Spine Injury, Physical Injury - Accidents and Adverse Effects, Neurosciences, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, acute phase reactant, alarmin, cytokine, neuroinflammation, prognosis, traumatic brain injury
Abstract

The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis. The prospective TRACK-TBI Pilot (Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot) study enrolled TBI patients triaged to head computed tomography (CT) and received blood draw within 24 h of injury. Healthy controls (HCs) and orthopedic controls (OCs) were included. Thirty-one inflammatory markers were analyzed from plasma. Area under the receiver operating characteristic curve (AUC) was used to evaluate discriminatory ability. AUC >0.7 was considered acceptable. Criteria included: TBI diagnosis (vs. OC/HC); moderate/severe vs. mild TBI (Glasgow Coma Scale; GCS); radiographic TBI (CT positive vs. CT negative); 3- and 6-month Glasgow Outcome Scale-Extended (GOSE) dichotomized to death/greater relative disability versus less relative disability (GOSE 1-4/5-8); and incomplete versus full recovery (GOSE

Published
2023

9. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts

Author

Ackerlund, Cecilia, Adams, Hadie, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McFadyen, Charles, McMahon, Catherine, Melegh, Béla, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Helmrich, Isabel Retel, Rhodes, Jonathan, Richter, Sophie, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Thibaut, Aurore, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Erp, Inge A., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, van Wijk, Roel, Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Peter, Whitehouse, Daniel, Wiegers, Eveline, Williams, Guy, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Adeoye, Opeolu, Badjatia, Neeraj, Barber, Jason, Bergin, Michael, Boase, Kim, Bodien, Yelena, Chesnut, Randall, Corrigan, John, Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Venkata, Ferguson, Adam R., Foreman, Brandon, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Grandhi, Ramesh, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Huie, Russell, Jha, Ruchira, Keene, Dirk C., Kitagawa, Ryan, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B., Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Ben Rodgers, Richard, Rosenthal, Eric, Sander, Angelle, Sandsmark, Danielle, Schneider, Andrea, Schnyer, David, Seabury, Seth, Sherer, Mark, Sugar, Gabriella, Temkin, Nancy, Toga, Arthur, Torres-Espin, Abel, Valadka, Alex, Vassar, Mary, Wang, Kevin, Wang, Vincent, Yue, John K., Yuh, Esther, Zafonte, Ross, Kals, Mart, Wilson, Lindsay, Levey, Daniel F., Parodi, Livia, Steyerberg, Ewout W., Richardson, Sylvia, He, Feng, Sun, Xiaoying, Jain, Sonia, Palotie, Aarno, Ripatti, Samuli, Rosand, Jonathan, Manley, Geoff T., Maas, Andrew I.R., Stein, Murray B., and Menon, David K.

Published
2024
Full Text
View/download PDF

11. Clinical profile of patients with acute traumatic brain injury undergoing cranial surgery in the United States: report from the 18-centre TRACK-TBI cohort study

Author

Chung, Jason E., Coskun, Bukre, Eagle, Shawn R., Etemad, Leila L., Fabian, Brian, Ramana, Feeser V., Gopinath, Shankar, Gotthardt, Christine J., Grandhi, Ramesh, Hamidi, Sabah, Jha, Ruchira M., Madden, Christopher, Merchant, Randall, Nelson, Lindsay D., Rodgers, Richard B., Schneider, Andrea L.C., Schnyer, David M., Torres-Espin, Abel, Tracey, Joye X., Valadka, Alex B., Zafonte, Ross D., Yue, John K., Kanter, John H., Barber, Jason K., Huang, Michael C., van Essen, Thomas A., Elguindy, Mahmoud M., Foreman, Brandon, Korley, Frederick K., Belton, Patrick J., Pisică, Dana, Lee, Young M., Kitagawa, Ryan S., Vassar, Mary J., Sun, Xiaoying, Satris, Gabriela G., Wong, Justin C., Ferguson, Adam R., Huie, J. Russell, Wang, Kevin K.W., Deng, Hansen, Wang, Vincent Y., Bodien, Yelena G., Taylor, Sabrina R., Madhok, Debbie Y., McCrea, Michael A., Ngwenya, Laura B., DiGiorgio, Anthony M., Tarapore, Phiroz E., Stein, Murray B., Puccio, Ava M., Giacino, Joseph T., Diaz-Arrastia, Ramon, Lingsma, Hester F., Mukherjee, Pratik, Yuh, Esther L., Robertson, Claudia S., Menon, David K., Maas, Andrew I.R., Markowitz, Amy J., Jain, Sonia, Okonkwo, David O., Temkin, Nancy R., and Manley, Geoffrey T.

Published
2024
Full Text
View/download PDF

12. Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury

Author

Badjatia, Neeraj, Diaz-Arrastia, Ramon, Duhaime, Ann-Christine, Feeser, V Ramana, Gopinath, Shankar, Grandhi, Ramesh, Ha, Ruchira J., Keene, Dirk, Madden, Christopher, McCrea, Michael, Merchant, Randall, Ngwenya, Laura B., Rodgers, Richard B., Schnyer, David, Taylor, Sabrina R., Zafonte, Ross, Ackerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Beer, Ronny, Bellander, Bo-Michael, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Beqiri, Erta, Blaabjerg, Morten, Lund, Stine Borgen, Brorsson, Camilla, Buki, Andras, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Ezer, Erzsébet, Fabricius, Martin, Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Galanaud, Damien, Gantner, Dashiell, Ghuysen, Alexandre, Giga, Lelde, Golubović, Jagoš, Gomez, Pedro A., Gravesteijn, Benjamin, Grossi, Francesca, Gupta, Deepak, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Huijben, Jilske, Hutchinson, Peter J., Jankowski, Stefan, Johnson, Faye, Karan, Mladen, Kolias, Angelos G., Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Menon, David, Menovsky, Tomas, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nyirádi, József, Ortolano, Fabrizio, Payen, Jean-François, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Ples, Horia, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rhodes, Jonathan, Richter, Sophie, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandrød, Oddrun, Schirmer-Mikalsen, Kari, Frederik Schou, Rico, Sewalt, Charlie, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Tenovuo, Olli, Thomas, Matt, Tibboel, Dick, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Essen, Thomas A., van Wijk, Roel, Vargiolu, Alessia, Vega, Emmanuel, Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, Vulekovic, Peter, Wiegers, Eveline, Williams, Guy, Winzeck, Stefan, Wolf, Stefan, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Samanta, Romit J., Chiollaz, Anne-Cécile, Needham, Edward, Yue, John K., Helmy, Adel, Zanier, Elisa R., Wang, Kevin K.W., Kobeissy, Firas, Summers, Charlotte, Manley, Geoffrey T., Maas, Andrew IR., Sanchez, Jean-Charles, and Menon, David K.

Published
2024
Full Text
View/download PDF

13. Improving the Precision of the Glasgow Outcome Scale-Extended Using Item Response Theory: A TRACK-TBI Study

Author

Magnus, Brooke E, Balsis, Steve, Giacino, Joseph T, McCrea, Michael A, Temkin, Nancy R, Whyte, John, Manley, Geoffrey T, Nelson, Lindsay D, Badjatia, Neeraj, Diaz-Arrastia, Ramon, Gopinath, Shankar, Grandhi, Ramesh, Jain, Sonia, Jain, Ruchira M, Keene, C Dirk, Donald, Christine Mac, Madden, Christopher, Ngwenya, Laura B, Okonkwo, David, Robertson, Claudia, Rodgers, Richard B, Schnyer, David, Schneider, Andrea, Taylor, Sabrina R, Espin, Abel, Yue, John K, and Zafonte, Ross

Subjects
Psychology, Applied and Developmental Psychology, Physical Injury - Accidents and Adverse Effects, Traumatic Brain Injury (TBI), Brain Disorders, Clinical Research, Traumatic Head and Spine Injury, Neurosciences, Brain Injuries, Traumatic, Disabled Persons, Glasgow Outcome Scale, Humans, Outcome Assessment, Health Care, Quality of Life, Glasgow Outcome Scale-Extended, item response theory, outcome measurement, psychometrics, TRACK-TBI Investigators, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

The Glasgow Outcome Scale-Extended (GOSE) is a functional outcome measure intended to place individuals with traumatic brain injury (TBI) into one of eight broad levels of injury-related disability. This simplicity is not always optimal, particularly when more granular assessment of individuals' injury recovery is desired. The GOSE, however, is customarily assessed using a multi-question interview that contains richer information than is reflected in the GOSE score. Using data from the multi-center Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) study (N = 1544), we used item response theory (IRT) to evaluate whether rescoring the GOSE using IRT, which posits that a continuous latent variable (disability) underlies responses, can yield a more precise index of injury-related functional limitations. We fit IRT models to GOSE interview responses collected at three months post-injury. Each participant's level of functional limitation was estimated from the model (GOSE-IRT) and comparisons were made between IRT-based and standard (GOSE-Ordinal) scores. The IRT scoring resulted in 141 possible scores (vs. 7 GOSE-Ordinal scores in this sample of individuals with GOSE scores ranging between 2 and 8). Moreover, GOSE-IRT scores were significantly more strongly associated with measures of TBI-related symptoms, psychological symptoms, and quality of life. Our findings demonstrate that rescoring the GOSE interview using IRT yields more granular, meaningful measurement of injury-related functional limitations, while adding no additional respondent or examiner burden. This technique may have utility for many applications, such as clinical trials aiming to detect small treatment effects, and small-scale studies that need to maximize statistical efficiency.

Published
2022

14. Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate - severe traumatic brain injury: A TRACK-TBI study

Author

Wongsripuemtet, Pattrapun, Ohnuma, Tetsu, Temkin, Nancy, Barber, Jason, Komisarow, Jordan, Manley, Geoffrey T., Hatfield, Jordan, Treggiari, Miriam, Colton, Katharine, Sasannejad, Cina, Chaikittisilpa, Nophanan, Ivins-O’Keefe, Kelly, Grandhi, Ramesh, Laskowitz, Daniel, Mathew, Joseph P., Hernandez, Adrian, James, Michael L., Raghunathan, Karthik, Miller, Joseph, Vavilala, Monica, and Krishnamoorthy, Vijay

Published
2024
Full Text
View/download PDF

18. Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury

Author

Ferguson, Adam R., Manley, Geoffrey T., Markowitz, Amy J., Mukherjee, Pratik, Taylor, Sabrina R., Yue, John K., Yuh, Esther L., Jha, Ruchira, Gopinath, Shankar, Robertson, Claudia S., Giacino, Joseph T., McCrea, Michael A., Nelson, Lindsay D., Diaz-Arrastia, Ramon, Jain, Sonia, Stein, Murray B., Ngwenya, Laura B., Badjatia, Neeraj, Gullapalli, Rao, Korley, Frederick K., Okonkwo, David O., Puccio, Ava M., Schnyer, David, Madden, Christopher, Grandhi, Ramesh, Dirk Keene, C., Mac Donald, Christine, Temkin, Nancy, Merchant, Randall, Cai, Lanya T., Brett, Benjamin L., Palacios, Eva M., Bourla, Ioanna, Wren-Jarvis, Jamie, Wang, Yang, Levin, Harvey S., and Zafonte, Ross D.

Published
2024
Full Text
View/download PDF

19. Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study*

Author

Liu, Sunny Yang, Kelly-Hedrick, Margot, Temkin, Nancy, Barber, Jason, Komisarow, Jordan, Hatfield, Jordan, Ohnuma, Tetsu, Manley, Geoffrey, Treggiari, Miriam M., Colton, Katharine, Vavilala, Monica S., Grandhi, Ramesh, Laskowitz, Daniel T., Mathew, Joseph P., Hernandez, Adrian, James, Michael L., Raghunathan, Karthik, Goldstein, Ben, Markowitz, Amy, Krishnamoorthy, Vijay, Badjatia, Neeraj, Ferguson, Adam R., Foreman, Brandon, Madden, Christopher, McCrea, Michael, Merchant, Randall, Ngwenya, Laura B., Okonkwo, David, Schnyer, David, Yue, John K., and Zafonte, Ross

Published
2024
Full Text
View/download PDF

23. Emerging Utility of Applied Magnetic Resonance Imaging in the Management of Traumatic Brain Injury

Author

Nadel, Jeffrey, McNally, Joseph Scott, DiGiorgio, Anthony, and Grandhi, Ramesh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Bioengineering, Neurosciences, Traumatic Head and Spine Injury, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Traumatic Brain Injury (TBI), Clinical Research, 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Injuries and accidents, Neurological, Brain Injuries, Traumatic, Diffusion Tensor Imaging, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Tomography, X-Ray Computed, MR perfusion, MR spectroscopy, diffusion tensor imaging, functional MRI, magnetic resonance imaging, traumatic brain injury, Biomedical and clinical sciences, Health sciences
Abstract

Traumatic brain injury (TBI) is a widespread and expensive problem globally. The standard diagnostic workup for new TBI includes obtaining a noncontrast computed tomography image of the head, which provides quick information on operative pathologies. However, given the limited sensitivity of computed tomography for identifying subtle but meaningful changes in the brain, magnetic resonance imaging (MRI) has shown better utility for ongoing management and prognostication after TBI. In recent years, advanced applications of MRI have been further studied and are being implemented as clinical tools to help guide care. These include functional MRI, diffusion tensor imaging, MR perfusion, and MR spectroscopy. In this review, we discuss the scientific basis of each of the above techniques, the literature supporting their use in TBI, and how they may be clinically implemented to improve the care of TBI patients.

Published
2021

24. Endovascular Thrombectomy for Pediatric Acute Ischemic Stroke: A Multi-Institutional Experience of Technical and Clinical Outcomes.

Author

Ravindra, Vijay M, Alexander, Matthew, Taussky, Philipp, Bollo, Robert J, Hassan, Ameer E, Scoville, Jonathan P, Griauzde, Julius, Awad, Al-Wala, Jumaa, Mouhammad, Zaidi, Syed, Lee, Jonathan J, Hafeez, Muhammad Ubaid, Nascimento, Fábio A, LoPresti, Melissa A, Couldwell, William T, Hetts, Steven W, Lam, Sandi K, Kan, Peter, and Grandhi, Ramesh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Neurosciences, Brain Disorders, Stroke, Hematology, Clinical Research, Adolescent, Child, Child, Preschool, Cohort Studies, Endovascular Procedures, Female, Humans, Ischemic Stroke, Longitudinal Studies, Male, Reperfusion, Retrospective Studies, Thrombectomy, Treatment Outcome, Cerebrovascular, Endovascular, Anticoagulation, Ischemic stroke, Pediatrics, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

BackgroundEndovascular thrombectomy is a promising treatment for acute ischemic stroke in children, but outcome and technical data in pediatric patients with large-vessel occlusions are lacking.ObjectiveTo assess technical and clinical outcomes of thrombectomy in pediatric patients.MethodsWe undertook a retrospective cohort study of pediatric patients who experienced acute ischemic stroke from April 2017 to April 2019 who had immediate, 30-, and 90-d follow-up. Patients were treated with endovascular thrombectomy at 5 US pediatric tertiary care facilities. We recorded initial and postprocedural modified Thrombolysis in Cerebral Infarction (mTICI) grade ≥ 2b, initial and postprocedural Pediatric National Institutes of Health Stroke Scale (PedNIHSS) score, and pediatric modified Rankin scale (mRS) score 0 to 2 at 90 d.ResultsThere were 23 thrombectomies in 21 patients (mean age 11.6 ± 4.9 yr, median 11.5, range 2.1-19; 52% female). A total of 19 (83%) thrombectomies resulted in mTICI grade ≥ 2b recanalization. The median PedNIHSS score was 13 on presentation (range 4-33) and 2 (range 0-26) at discharge (mean reduction 11.3 ± 6.1). A total of 14 (66%) patients had a mRS score of 0 to 2 at 30-d follow-up; 18/21 (86%) achieved that by 90 d. The median mRS was 1 (range 0-4) at 30 d and 1 (range 0-5) at 90 d. One patient required a blood transfusion after thrombectomy.ConclusionIn this large series of pediatric patients treated with endovascular thrombectomy, successful recanalization was accomplished via a variety of approaches with excellent clinical outcomes; further prospective longitudinal study is needed.

Published
2021

25. Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study

Author

Badjatia, Neeraj, Feeser, V. Ramana, Gopinath, Shankar, Grandhi, Ramesh, Keene, C. Dirk, Kitagawa, Ryan, Korley, Frederick K., Donald, Christine Mac, Madden, Christopher, Mukherjee, Pratik, Ngwenya, Laura B., Okonkwo, David, Robertson, Claudia, Rodgers, Richard B., Schnyer, David, Taylor, Sabrina R., Vassar, Mary, Yue, John K., Zafonte, Ross, Ashina, Håkan, Dodick, David W., Barber, Jason, Temkin, Nancy R., Chong, Catherine D., Adler, Jennifer S., Stein, Ken Shubin, Schwedt, Todd J., and Manley, Geoffrey T.

Published
2023
Full Text
View/download PDF

27. Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study

Author

Liu, Sunny Yang, Kelly-Hedrick, Margot, Temkin, Nancy, Barber, Jason, Komisarow, Jordan, Hatfield, Jordan, Ohnuma, Tetsu, Manley, Geoffrey, Treggiari, Miriam M., Colton, Katharine, Vavilala, Monica S., Grandhi, Ramesh, Laskowitz, Daniel T., Mathew, Joseph P., Hernandez, Adrian, James, Michael L., Raghunathan, Karthik, Goldstein, Ben, Markowitz, Amy, Krishnamoorthy, Vijay, Badjatia, Neeraj, Ferguson, Adam R., Foreman, Brandon, Madden, Christopher, McCrea, Michael, Merchant, Randall, Ngwenya, Laura B., Okonkwo, David, Schnyer, David, Yue, John K., and Zafonte, Ross

Published
2023
Full Text
View/download PDF

29. Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study

Author

Adeoye, Opeolu, Badatjia, Neeraj, Duhaime, Ann-Christine, Ferguson, Adam, Foreman, Brandon, Giacino, Joseph T, Gopinath, Shankar, Grandhi, Ramesh, Kitagawa, Ryan, Madden, Christopher, Merchant, Randall, McCrea, Mike, Ngwenya, Laura, Rabinowitz, Miri, Robertson, Claudia, Schnyer, David, Stein, Murray, Vassar, Mary, Wang, Vincent, Valadka, Alex, Zafonte, Ross, Korley, Frederick K, Jain, Sonia, Sun, Xiaoying, Puccio, Ava M, Yue, John K, Gardner, Raquel C, Wang, Kevin K W, Okonkwo, David O, Yuh, Esther L, Mukherjee, Pratik, Nelson, Lindsay D, Taylor, Sabrina R, Markowitz, Amy J, Diaz-Arrastia, Ramon, and Manley, Geoffrey T

Published
2022
Full Text
View/download PDF

31. Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation

Author

Ackerlund, Cecilia, Adams, Hadie, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Carbayo Lozano, Guillermo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Covic, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, den Boogert, Hugo, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McFadyen, Charles, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Retel Helmrich, Isabel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Erp, Inge A., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, van Wijk, Roel, Vande Vyvere, Thijs, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Peter, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Adeoye, Opeolu, Badjatia, Neeraj, Barber, Jason, Bergin, Michael, Boase, Kim, Bodien, Yelena, Chesnut, Randall, Corrigan, John, Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Venkata, Ferguson, Adam R, Foreman, Brandon, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Grandhi, Ramesh, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Huie, Russell, Jha, Ruchira, Keene, C. Dirk, Kitagawa, Ryan, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B., Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rodgers, Richard Ben, Rosand, Jonathan, Rosenthal, Eric, Sander, Angelle, Sandsmark, Danielle, Sugar, Gabriella, Schneider, Andrea, Schnyer, David, Seabury, Seth, Sherer, Mark, Stein, Murray, Temkin, Nancy, Toga, Arthur, Torres-Espin, Abel, Valadka, Alex, Vassar, Mary, Wang, Kevin, Wang, Vincent, Yue, John K., Yuh, Esther, Zafonte, Ross, Galimberti, Stefania, Graziano, Francesca, Maas, Andrew I R, Isernia, Giulia, Lecky, Fiona, Jain, Sonia, Sun, Xiaoying, Gardner, Raquel C, Taylor, Sabrina R, Markowitz, Amy J, Manley, Geoffrey T, Valsecchi, Maria Grazia, Bellelli, Giuseppe, and Citerio, Giuseppe

Published
2022
Full Text
View/download PDF

36. Management of failed flow diversion for intracranial aneurysm beyond the first 6 months of follow-up: an international Delphi consensus.

Author

Chintapalli, Renuka, Nguyen, Sarah, Taussky, Philipp, Grandhi, Ramesh, Dammann, Philipp, Raygor, Kunal, Tonetti, Daniel A., Andersson, Tommy, White, Philip, Ogilvy, Christopher S., Chapot, Rene, Fox, W. Christopher, Tawk, Rabih G., Lanzino, Giuseppe, Hanel, Ricardo, Jadhav, Ashutosh, Hassan, Ameer E., Linfante, Italo, Almefty, Rami, and Mascitelli, Justin

Published
2024
Full Text
View/download PDF

37. Thrombectomy for Stroke With Large Infarct on Noncontrast CT: The TESLA Randomized Clinical Trial.

Author

Yoo, Albert J., Zaidat, Osama O., Sheth, Sunil A., Rai, Ansaar T., Ortega-Gutierrez, Santiago, Given II, Curtis A., Zaidi, Syed F., Grandhi, Ramesh, Cuellar, Hugo, Mokin, Maxim, Katz, Jeffrey M., Alshekhlee, Amer, Taqi, Muhammad A., Ansari, Sameer A., Siddiqui, Adnan H., Barazangi, Nobl, English, Joey D., Maud, Alberto, Kirmani, Jawad, and Gupta, Rishi

Subjects
INTRACRANIAL hemorrhage, MEDICAL care, ENDOVASCULAR surgery, SUBARACHNOID hemorrhage, STROKE
Abstract

Key Points: Question: Does endovascular thrombectomy improve functional outcome in patients with a large infarct on noncontrast computed tomographic (CT) scan within 24 hours of stroke onset? Findings: In this randomized trial of 300 patients, thrombectomy did not significantly improve 90-day functional outcome compared with medical management alone for the primary end point (adjusted difference in utility-weighted modified Rankin Scale score, 0.63). Meaning: Among patients with large infarct detected by noncontrast CT and presenting within 24 hours, thrombectomy did not significantly improve functional outcome at 90 days. Importance: Recent large infarct thrombectomy trials used heterogeneous imaging modalities and time windows for patient selection. Noncontrast computed tomographic (CT) scan is the most common stroke imaging approach. It remains uncertain whether thrombectomy is effective for patients with large infarcts identified using noncontrast CT alone within 24 hours of stroke onset. Objective: To evaluate the effect of thrombectomy in patients with a large infarct on a noncontrast CT scan within 24 hours of onset. Design, Setting, and Participants: Open-label, blinded–end point, bayesian-adaptive randomized trial with interim analyses for early stopping (futility or success) or population enrichment, which was conducted at 47 US academic and community-based stroke thrombectomy centers. Three hundred patients presenting within 24 hours with anterior-circulation, large-vessel occlusion and large infarct on noncontrast CT scan, with Alberta Stroke Program Early CT Scores of 2 to 5, were randomized to undergo thrombectomy or usual care. Enrollment occurred July 16, 2019 to October 17, 2022; final follow-up, January 25, 2023. Intervention: The intervention patients (n = 152) underwent endovascular treatment using standard thrombectomy devices and usual medical care. Control patients (n = 148) underwent usual medical care alone. Main Outcomes and Measures: The primary efficacy end point was improvement in 90-day functional outcome measured using mean utility-weighted modified Rankin Scale (UW-mRS) scores (range, 0 [death or severe disability] to 10 [no symptoms]; minimum clinically important difference, 0.3). A bayesian model determined the posterior probability that the intervention would be superior to usual care; statistical significance was a 1-sided posterior probability of.975 or more. The primary adverse event end point was 90-day mortality; secondary adverse event end points included symptomatic intracranial hemorrhage and radiographic intracranial hemorrhage. Results: The trial enrolled 300 patients (152 intervention, 148 control; 138 females [46%]; median age, 67 years), without early stopping or enrichment; 297 patients completed the 90-day follow-up. The mean (SD) 90-day UW-mRS score was 2.93 (3.39) for the intervention group vs 2.27 (2.98) for the control group with an adjusted difference of 0.63 (95% credible interval [CrI], −0.09 to 1.34; posterior probability for superiority of thrombectomy,.96). The 90-day mortality was similar between groups: 35.3% (53 of 150) for the intervention group vs 33.3% (49 of 147) for the control group. Six of 151 patients (4.0%) in the intervention group and 2 of 149 (1.3%) in the control group experienced 24-hour symptomatic intracranial hemorrhage. Fourteen patients of 148 (9.5%) in the intervention group vs 4 of 146 (2.7%) in the control group experienced parenchymal hematoma type 1 hemorrhages; 14 (9.5%) in the intervention group vs 5 (3.4%) in the control group experienced parenchymal hematoma type 2 hemorrhages; and 24 (16.2%) in the intervention group vs 9 (6.2%) in the control group experienced subarachnoid hemorrhages. Conclusions and Relevance: Among patients with a large infarct on noncontrast CT within 24 hours, thrombectomy did not demonstrate improvement in functional outcomes. But the width of the credible interval around the effect estimate includes the possibility of both no important effect and a clinically relevant benefit, so the potential role of thrombectomy with this imaging approach and time window will likely require additional study. Trial Registration: ClinicalTrials.gov Identifier: NCT03805308 This clinical trial evaluates whether endovascular thrombectomy and usual medical care vs medical care alone improves functional outcomes among patients who present within 24 hours after symptom onset with anterior-circulation, large-vessel occlusion, and large infarct detected by noncontrast CT scan. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. Impact of Race on Outcomes in the Endovascular and Microsurgical Treatment in Patients With Intracranial Aneurysms.

Author

Hidetoshi Matsukawa, Kazutaka Uchida, Sowlat, Mohammad-Mahdi, Elawady, Sameh Samir, Cunningham, Conor, Alawieh, Ali, Kasab, Sami Al, Jabbour, Pascal, Mascitelli, Justin, Levitt, Michael R., Cuellar, Hugo, Brinjikji, Waleed, Samaniego, Edgar, Burkhardt, Jan-Karl, Kan, Peter, Fox, W. Christopher, Moss, Mark, Ezzeldin, Mohamad, Grandhi, Ramesh, and Altschul, David J.

Published
2024
Full Text
View/download PDF

41. Impact of Race on Outcomes in the Endovascular and Microsurgical Treatment in Patients With Intracranial Aneurysms

Author

Matsukawa, Hidetoshi, primary, Uchida, Kazutaka, additional, Sowlat, Mohammad-Mahdi, additional, Elawady, Sameh Samir, additional, Cunningham, Conor, additional, Alawieh, Ali, additional, Al Kasab, Sami, additional, Jabbour, Pascal, additional, Mascitelli, Justin, additional, Levitt, Michael R., additional, Cuellar, Hugo, additional, Brinjikji, Waleed, additional, Samaniego, Edgar, additional, Burkhardt, Jan-Karl, additional, Kan, Peter, additional, Fox, W. Christopher, additional, Moss, Mark, additional, Ezzeldin, Mohamad, additional, Grandhi, Ramesh, additional, Altschul, David J., additional, Spiotta, Alejandro M, additional, and Yoshimura, Shinichi, additional

Published
2024
Full Text
View/download PDF

42. The Influence of Coagulopathy on Radiographic and Clinical Outcomes in Patients Undergoing Middle Meningeal Artery Embolization as Standalone Treatment for Non-acute Subdural Hematomas

Author

Salah, Walid K., primary, Findlay, Matthew C., additional, Baker, Cordell M., additional, Scoville, Jonathan P., additional, Bounajem, Michael T., additional, Ogilvy, Christopher S., additional, Moore, Justin M., additional, Riina, Howard A., additional, Levy, Elad I., additional, Siddiqui, Adnan H., additional, Spiotta, Alejandro M., additional, Cawley, C. Michael, additional, Khalessi, Alexander A., additional, Tanweer, Omar, additional, Hanel, Ricardo, additional, Gross, Bradley A., additional, Kuybu, Okkes, additional, Howard, Brian M., additional, Hoang, Alex N., additional, Baig, Ammad A., additional, Khorasanizadeh, MirHojjat, additional, Mendez Ruiz, Aldo A., additional, Cortez, Gustavo, additional, Davies, Jason M., additional, Lang, Michael J., additional, Thomas, Ajith J., additional, Tonetti, Daniel A., additional, Khalife, Jane, additional, Sioutas, Georgios S., additional, Carroll, Kate, additional, Abecassis, Zachary A., additional, Jankowitz, Brian T., additional, Ruiz Rodriguez, Juan, additional, Levitt, Michael R., additional, Kan, Peter T., additional, Burkhardt, Jan-Karl, additional, Srinivasan, Visish, additional, Salem, Mohamed M., additional, and Grandhi, Ramesh, additional

Published
2024
Full Text
View/download PDF

46. Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study

Author

Yue, John K., primary, Lee, Young M., additional, Sun, Xiaoying, additional, van Essen, Thomas A., additional, Elguindy, Mahmoud M., additional, Belton, Patrick J., additional, Pisică, Dana, additional, Mikolic, Ana, additional, Deng, Hansen, additional, Kanter, John H., additional, McCrea, Michael A., additional, Bodien, Yelena G., additional, Satris, Gabriela G., additional, Wong, Justin C., additional, Ambati, Vardhaan S., additional, Grandhi, Ramesh, additional, Puccio, Ava M., additional, Mukherjee, Pratik, additional, Valadka, Alex B., additional, Tarapore, Phiroz E., additional, Huang, Michael C., additional, DiGiorgio, Anthony M., additional, Markowitz, Amy J., additional, Yuh, Esther L., additional, Okonkwo, David O., additional, Steyerberg, Ewout W., additional, Lingsma, Hester F., additional, Menon, David K., additional, Maas, Andrew I. R., additional, Jain, Sonia, additional, Manley, Geoffrey T., additional, _, _, additional, Badjatia, Neeraj, additional, Barber, Jason, additional, Chesnut, Randall M., additional, Diaz-Arrastia, Ramon, additional, Duhaime, Ann-Christine, additional, Eagle, Shawn R., additional, Etemad, Leila L., additional, Fabian, Brian, additional, Ferguson, Adam R., additional, Foreman, Brandon, additional, Gardner, Raquel C., additional, Giacino, Joseph T., additional, Gopinath, Shankar, additional, Gotthardt, Christine J., additional, Hamidi, Sabah, additional, Huie, J. Russell, additional, Keene, C. Dirk, additional, Korley, Frederick K., additional, Madhok, Debbie Y., additional, Madden, Christopher, additional, Merchant, Randall, additional, Nelson, Lindsay D., additional, Ngwenya, Laura B., additional, Robertson, Claudia S., additional, Rodgers, Richard B, additional, Schneider, Andrea L. C., additional, Schnyer, David M., additional, Stein, Murray B., additional, Taylor, Sabrina R., additional, Temkin, Nancy R., additional, Torres-Espin, Abel, additional, Tracey, Joye X., additional, Vassar, Mary J., additional, Wang, Kevin K. W., additional, and Zafonte, Ross D., additional

Published
2024
Full Text
View/download PDF

50. Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury

Author

Samanta, R, Chiollaz, A, Needham, E, Yue, J, Helmy, A, Zanier, E, Wang, K, Kobeissy, F, Posti, J, Summers, C, Manley, G, Maas, A, Tenovuo, O, Sanchez, J, Menon, D, Badjatia, N, Diaz-Arrastia, R, Duhaime, A, Feeser, V, Gopinath, S, Grandhi, R, Ha, R, Keene, D, Madden, C, Mccrea, M, Merchant, R, Ngwenya, L, Rodgers, R, Schnyer, D, Taylor, S, Zafonte, R, Ackerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Beer, R, Bellander, B, Benali, H, Berardino, M, Beretta, L, Beqiri, E, Blaabjerg, M, Lund, S, Brorsson, C, Buki, A, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Castaño-León, A, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, De Keyser, V, Degos, V, Della Corte, F, Boogert, H, Depreitere, B, Đilvesi, Đ, Dixit, A, Dreier, J, Dulière, G, Ercole, A, Ezer, E, Fabricius, M, Foks, K, Frisvold, S, Furmanov, A, Galanaud, D, Gantner, D, Ghuysen, A, Giga, L, Golubović, J, Gomez, P, Gravesteijn, B, Grossi, F, Gupta, D, Haitsma, I, Helbok, R, Helseth, E, Huijben, J, Hutchinson, P, Jankowski, S, Johnson, F, Karan, M, Kolias, A, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovács, N, Kowark, A, Lagares, A, Laureys, S, Lecky, F, Ledoux, D, Lightfoot, R, Lingsma, H, Manara, A, Maréchal, H, Martino, C, Mattern, J, Mcmahon, C, Menovsky, T, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nyirádi, J, Ortolano, F, Payen, J, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Ples, H, Pomposo, I, Puybasset, L, Rădoi, A, Ragauskas, A, Raj, R, Rhodes, J, Richter, S, Rocka, S, Roe, C, Roise, O, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandrød, O, Schirmer-Mikalsen, K, Frederik Schou, R, Sewalt, C, Smielewski, P, Sorinola, A, Stamatakis, E, Steyerberg, E, Stocchetti, N, Sundström, N, Takala, R, Tamás, V, Tamosuitis, T, Thomas, M, Tibboel, D, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Valeinis, E, Vallance, S, Vámos, Z, Van der Steen, G, van Dijck, J, van Essen, T, van Wijk, R, Vargiolu, A, Vega, E, Vik, A, Vilcinis, R, Volovici, V, Vulekovic, P, Wiegers, E, Williams, G, Winzeck, S, Wolf, S, Younsi, A, Zeiler, F, Ziverte, A, Zoerle, T, Samanta, Romit J., Chiollaz, Anne-Cécile, Needham, Edward, Yue, John K., Helmy, Adel, Zanier, Elisa R., Wang, Kevin K. W., Kobeissy, Firas, Posti, Jussi P., Summers, Charlotte, Manley, Geoffrey T., Maas, Andrew IR., Tenovuo, Olli, Sanchez, Jean-Charles, Menon, David K., Badjatia, Neeraj, Diaz-Arrastia, Ramon, Duhaime, Ann-Christine, Feeser, V Ramana, Gopinath, Shankar, Grandhi, Ramesh, Ha, Ruchira J., Keene, Dirk, Madden, Christopher, McCrea, Michael, Merchant, Randall, Ngwenya, Laura B., Rodgers, Richard B., Schnyer, David, Taylor, Sabrina R., Zafonte, Ross, Ackerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Beer, Ronny, Bellander, Bo-Michael, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Beqiri, Erta, Blaabjerg, Morten, Lund, Stine Borgen, Brorsson, Camilla, Buki, Andras, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Ezer, Erzsébet, Fabricius, Martin, Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Galanaud, Damien, Gantner, Dashiell, Ghuysen, Alexandre, Giga, Lelde, Golubović, Jagoš, Gomez, Pedro A., Gravesteijn, Benjamin, Grossi, Francesca, Gupta, Deepak, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Huijben, Jilske, Hutchinson, Peter J., Jankowski, Stefan, Johnson, Faye, Karan, Mladen, Kolias, Angelos G., Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I. R., Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Menon, David, Menovsky, Tomas, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nyirádi, József, Ortolano, Fabrizio, Payen, Jean-François, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Ples, Horia, Pomposo, Inigo, Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rhodes, Jonathan, Richter, Sophie, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandrød, Oddrun, Schirmer-Mikalsen, Kari, Frederik Schou, Rico, Sewalt, Charlie, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Thomas, Matt, Tibboel, Dick, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Steen, Gregory, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel, Vargiolu, Alessia, Vega, Emmanuel, Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, Vulekovic, Peter, Wiegers, Eveline, Williams, Guy, Winzeck, Stefan, Wolf, Stefan, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Samanta, R, Chiollaz, A, Needham, E, Yue, J, Helmy, A, Zanier, E, Wang, K, Kobeissy, F, Posti, J, Summers, C, Manley, G, Maas, A, Tenovuo, O, Sanchez, J, Menon, D, Badjatia, N, Diaz-Arrastia, R, Duhaime, A, Feeser, V, Gopinath, S, Grandhi, R, Ha, R, Keene, D, Madden, C, Mccrea, M, Merchant, R, Ngwenya, L, Rodgers, R, Schnyer, D, Taylor, S, Zafonte, R, Ackerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Beer, R, Bellander, B, Benali, H, Berardino, M, Beretta, L, Beqiri, E, Blaabjerg, M, Lund, S, Brorsson, C, Buki, A, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Castaño-León, A, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, De Keyser, V, Degos, V, Della Corte, F, Boogert, H, Depreitere, B, Đilvesi, Đ, Dixit, A, Dreier, J, Dulière, G, Ercole, A, Ezer, E, Fabricius, M, Foks, K, Frisvold, S, Furmanov, A, Galanaud, D, Gantner, D, Ghuysen, A, Giga, L, Golubović, J, Gomez, P, Gravesteijn, B, Grossi, F, Gupta, D, Haitsma, I, Helbok, R, Helseth, E, Huijben, J, Hutchinson, P, Jankowski, S, Johnson, F, Karan, M, Kolias, A, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovács, N, Kowark, A, Lagares, A, Laureys, S, Lecky, F, Ledoux, D, Lightfoot, R, Lingsma, H, Manara, A, Maréchal, H, Martino, C, Mattern, J, Mcmahon, C, Menovsky, T, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nyirádi, J, Ortolano, F, Payen, J, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Ples, H, Pomposo, I, Puybasset, L, Rădoi, A, Ragauskas, A, Raj, R, Rhodes, J, Richter, S, Rocka, S, Roe, C, Roise, O, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandrød, O, Schirmer-Mikalsen, K, Frederik Schou, R, Sewalt, C, Smielewski, P, Sorinola, A, Stamatakis, E, Steyerberg, E, Stocchetti, N, Sundström, N, Takala, R, Tamás, V, Tamosuitis, T, Thomas, M, Tibboel, D, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Valeinis, E, Vallance, S, Vámos, Z, Van der Steen, G, van Dijck, J, van Essen, T, van Wijk, R, Vargiolu, A, Vega, E, Vik, A, Vilcinis, R, Volovici, V, Vulekovic, P, Wiegers, E, Williams, G, Winzeck, S, Wolf, S, Younsi, A, Zeiler, F, Ziverte, A, Zoerle, T, Samanta, Romit J., Chiollaz, Anne-Cécile, Needham, Edward, Yue, John K., Helmy, Adel, Zanier, Elisa R., Wang, Kevin K. W., Kobeissy, Firas, Posti, Jussi P., Summers, Charlotte, Manley, Geoffrey T., Maas, Andrew IR., Tenovuo, Olli, Sanchez, Jean-Charles, Menon, David K., Badjatia, Neeraj, Diaz-Arrastia, Ramon, Duhaime, Ann-Christine, Feeser, V Ramana, Gopinath, Shankar, Grandhi, Ramesh, Ha, Ruchira J., Keene, Dirk, Madden, Christopher, McCrea, Michael, Merchant, Randall, Ngwenya, Laura B., Rodgers, Richard B., Schnyer, David, Taylor, Sabrina R., Zafonte, Ross, Ackerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Beer, Ronny, Bellander, Bo-Michael, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Beqiri, Erta, Blaabjerg, Morten, Lund, Stine Borgen, Brorsson, Camilla, Buki, Andras, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Ezer, Erzsébet, Fabricius, Martin, Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Galanaud, Damien, Gantner, Dashiell, Ghuysen, Alexandre, Giga, Lelde, Golubović, Jagoš, Gomez, Pedro A., Gravesteijn, Benjamin, Grossi, Francesca, Gupta, Deepak, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Huijben, Jilske, Hutchinson, Peter J., Jankowski, Stefan, Johnson, Faye, Karan, Mladen, Kolias, Angelos G., Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I. R., Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Menon, David, Menovsky, Tomas, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nyirádi, József, Ortolano, Fabrizio, Payen, Jean-François, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Ples, Horia, Pomposo, Inigo, Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rhodes, Jonathan, Richter, Sophie, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandrød, Oddrun, Schirmer-Mikalsen, Kari, Frederik Schou, Rico, Sewalt, Charlie, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Thomas, Matt, Tibboel, Dick, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Steen, Gregory, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel, Vargiolu, Alessia, Vega, Emmanuel, Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, Vulekovic, Peter, Wiegers, Eveline, Williams, Guy, Winzeck, Stefan, Wolf, Stefan, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, and Zoerle, Tommaso

Abstract

Background: The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes. Methods: Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover (Collaborative European NeuroTrauma Effectiveness Research [CENTER-TBI], Europe) and validate (Transforming Research and Clinical Knowledge in Traumatic Brain Injury [TRACK-TBI] Pilot, USA) individual variations in the immune response using a multiplex panel of 30 inflammatory mediators. Mediators that were associated with unfavourable outcomes (Glasgow outcome score-extended [GOS-E] ≤ 4) were used for hierarchical clustering to identify patients with similar signatures. Findings: Two clusters were identified in both the discovery and validation cohorts, termed early-inflammatory and pauci-inflammatory. The early-inflammatory phenotype had higher concentrations of interleukin-6 (IL-6), IL-15, and monocyte chemoattractant protein 1 (MCP1). Patients with the early-inflammatory phenotype were older and more likely to have an unfavourable GOS-E at 6 months. There were no differences in the baseline injury severity scores between patients in each phenotype. A combined IL-15 and MCP1 signature identified patients with the early-inflammatory phenotype in both cohorts. Inflammatory processes mediated outcomes in older patients with moderate-severe TBI. Interpretation: Our findings offer a precision medicine approach for future clinical trials of immunomodulation in patients with TBI, by using inflammatory signatures to stratify patients.

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results