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4. Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis

Author

Muharram, Ghaffar, primary, Thépaut, Marion, additional, Lobert, Pierre-Emmanuel, additional, Grandjean, Teddy, additional, Boulard, Olivier, additional, Delacre, Myriam, additional, Wakeford, Emmrich, additional, Wheeler, Richard, additional, Poulin, Lionel Franz, additional, Boneca, Ivo Gomperts, additional, Lafont, Frank, additional, Michallet, Marie-Cécile, additional, Hober, Didier, additional, Cadwell, Ken, additional, and Chamaillard, Mathias, additional

Published
2023
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6. Activation of Nod2 signalling upon Norovirus infection enhances antiviral immunity and susceptibility to colitis

Author

Muharram, Ghaffar, Thépaut, Marion, Lobert, Pierre-Emmanuel, Grandjean, Teddy, Boulard, Olivier, Delacre, Myriam, Wakeford, Emmrich, Wheeler, Richard, Poulin, Lionel, Gomperts Boneca, Ivo, Lafont, Frank, Michallet, Marie-Cécile, Hober, Didier, Cadwell, Ken, Chamaillard, Mathias, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Pathogenèse virale du diabète de type 1 - ULR 3610 (Laboratoire de Virologie), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 (PHYCELL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall, Institut Pasteur [Paris] (IP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), New York University School of Medicine (NYU Grossman School of Medicine), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-RHUS-0008,LUMIERE,LUMIERE(2016), and ANR-16-CE15-0021,PG-Brain,Modulation de l'activité du cerveau par le peptidoglycan bactérien(2016)

Subjects
Inflammation, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Macrophages, Norovirus, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Signalling, Colitis, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, NOD2
Abstract

International audience; Over 90% of epidemic nonbacterial gastroenteritis are caused by human Noroviruses (NoV) which are persisting in a substantial subset of people allowing their spread worldwide. It leads to a significant number of endemic cases and up to 70,000 children deaths in developing countries. NoVs are primarily transmitted through the fecal-oral route. To date studies have focused on the influence of the gut microbiota on viral clearance by enteric immunity. In this study, the use of the persistent mouse Norovirus S99 strain (MNoV_S99) allowed us to provide evidence that the norovirus-driven exacerbation of colitis severity relied on bacterial sensing by nucleotide-binding oligomerization domain 2 (Nod2). Similarly, another persistent MNoV_CR6 strain failed to exacerbate colitis severity in Nod2-deficient mice. In parallel, the viremia was heightened in these mice in comparison with control animals. Accordingly, a reduced level of phosphorylation of Signal Transducer and Activator of Transcription1 (STAT1) in Nod2-deficient macrophages infected by MNoV_S99 was measured. By contrast, STAT1 phosphorylation was increased in wild-type macrophages and associated with an induction of NOD2 expression. This in turn enhances myeloid cells response to muramyl dipeptide (MDP) resulting in downstream pro-inflammatory cytokine secretion and reduced noroviral production. Hence, our results uncover a previously unidentified virus-host-bacterial interplay that may represent a novel therapeutic target for treating noroviral origin gastroenteritis that may be linked with susceptibility to several common illnesses such as Crohn’s disease.

Published
2023

10. Characterization of the Achromobacter xylosoxidans Type VI Secretion System and Its Implication in Cystic Fibrosis

Author

Le Goff, Mélanie, primary, Vastel, Manon, additional, Lebrun, Régine, additional, Mansuelle, Pascal, additional, Diarra, Ava, additional, Grandjean, Teddy, additional, Triponney, Pauline, additional, Imbert, Geneviève, additional, Gosset, Philippe, additional, Dessein, Rodrigue, additional, Garnier, Fabien, additional, and Durand, Eric, additional

Published
2022
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12. Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

Author

Peyrin-Biroulet, Laurent, Beisner, Julia, Wang, Guoxing, Nuding, Sabine, Oommen, Sajit Thottathil, Kelly, Denise, Parmentier-Decrucq, Erika, Dessein, Rodrigue, Merour, Emilie, Chavatte, Philipe, Grandjean, Teddy, Bressenot, Aude, Desreumaux, Pierre, Colombel, Jean-Frédéric, Desvergne, Béatrice, Stange, Eduard F., Wehkamp, Jan, and Chamaillard, Mathias

Published
2010

13. Pseudomonas aeruginosa Biofilm Dispersion by the Human Atrial Natriuretic Peptide

Author

Louis, Mélissande, primary, Clamens, Thomas, additional, Tahrioui, Ali, additional, Desriac, Florie, additional, Rodrigues, Sophie, additional, Rosay, Thibaut, additional, Harmer, Nicholas, additional, Diaz, Suraya, additional, Barreau, Magalie, additional, Racine, Pierre‐Jean, additional, Kipnis, Eric, additional, Grandjean, Teddy, additional, Vieillard, Julien, additional, Bouffartigues, Emeline, additional, Cornelis, Pierre, additional, Chevalier, Sylvie, additional, Feuilloley, Marc G. J., additional, and Lesouhaitier, Olivier, additional

Published
2022
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15. A Protective Role of NOD2 on Oxazolone-induced Intestinal Inflammation Through IL-1β-mediated Signalling Pathway.

Author

Secher, Thomas, Couturier, Aurélie, Huot, Ludovic, Bouscayrol, Helene, Grandjean, Teddy, Boulard, Olivier, Hot, David, Ryffel, Bernhard, and Chamaillard, Mathias

Abstract

Background and Aims NOD2 has emerged as a critical player in the induction of both Th1 and Th2 responses for potentiation and polarisation of antigen-dependent immunity. Loss-of-function mutations in the NOD2-encoding gene and deregulation of its downstream signalling pathway have been linked to Crohn's disease. Although it is well documented that NOD2 is capable of sensing bacterial muramyl dipeptide, it remains counter-intuitive to link development of overt intestinal inflammation to a loss of bacterial-induced inflammatory response. We hypothesised that a T helper bias could also contribute to an autoimmune-like colitis different from inflammation that is fully fledged by Th1 type cells. Methods An oedematous bowel wall with a mixed Th1/Th2 response was induced in mice by intrarectal instillation of the haptenating agent oxazolone. Survival and clinical scoring were evaluated. At several time points after instillation, colonic damage was assessed by macroscopic and microscopic observations. To evaluate the involvement of NOD2 in immunochemical phenomena, quantitative polymerase chain reaction [PCR] and flow cytometry analysis were performed. Bone marrow chimera experimentation allowed us to evaluate the role of haematopoietic/non-hematopoietic NOD2-expressing cells. Results Herein, we identified a key regulatory circuit whereby NOD2-mediated sensing of a muramyl dipeptide [MDP] by radio-resistant cells improves colitis with a mixed Th1/Th2 response that is induced by oxazolone. Genetic ablation of either Nod2 or Ripk2 precipitated oxazolone colitis that is predominantly linked to a lack of interferon-gamma. Bone marrow chimera experiments revealed that inactivation of Nod2 signalling in non-haematopoietic cells is causing a biased M1-M2 polarisation of macrophages and a decreased frequency of splenic regulatory T cells that correlates with an impaired activation of CD4 + T cells within mesenteric lymph nodes. Mechanistically, mice were protected from oxazolone-induced colitis upon administration of MDP in an interleukin-1- and interleukin-23-dependent manner. Conclusions These findings indicate that Nod2 signalling may prevent pathological conversion of T helper cells for maintenance of tissue homeostasis. [ABSTRACT FROM AUTHOR]

Published
2023
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16. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

Author

Couturier-Maillard, Aurelie, Secher, Thomas, Rehman, Ateequr, Normand, Sylvain, Arcangelis, Adele De, Haesler, Robert, Huot, Ludovic, Grandjean, Teddy, Bressenot, Aude, Delanoye-Crespin, Anne, Gaillot, Olivier, Schreiber, Stefan, Lemoine, Yves, Ryffel, Bernhard, Hot, David, Nunez, Gabriel, Chen, Grace, Rosenstiel, Philip, and Chamaillard, Mathias

Subjects
Microbiota (Symbiotic organisms) -- Physiological aspects -- Genetic aspects -- Research, Colorectal cancer -- Health aspects -- Risk factors -- Genetic aspects -- Care and treatment -- Research, Colitis -- Health aspects -- Risk factors -- Genetic aspects -- Care and treatment -- Research, Health care industry
Abstract

Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, such as Crohn's disease and colorectal cancer. Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice. Loss of either Nod2 or RIP2 resulted in a proinflammatory microenvironment that enhanced epithelial dysplasia following chemically induced injury. The condition could be improved by treatment with antibiotics or an anti-interleukin-6 receptor-neutralizing antibody. Genotype-dependent disease risk was communicable via maternally transmitted microbiota in both Nod2-deficient and WT hosts. Furthermore, reciprocal microbiota transplantation reduced disease risk in Nod2-deficient mice and led to long-term changes in intestinal microbial communities. Conversely, disease risk was enhanced in WT hosts that were recolonized with dysbiotic fecal microbiota from Nod2-deficient mice. Thus, we demonstrated that licensing of dysbiotic microbiota is a critical component of disease risk. Our results demonstrate that NOD2 has an unexpected role in shaping a protective assembly of gut bacterial communities and suggest that manipulation of dysbiosis is a potential therapeutic approach in the treatment of human intestinal disorders., Introduction The gut flora is composed of a huge number of diverse microbial communities, within which Bacteroidetes, Firmicutes, and Proteobacteria are the dominant phyla (1), (2). In humans, the coexistence [...]

Published
2013
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19. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

Author

Sedhom, Mamdouh A K, Pichery, Mélanie, Murdoch, Jenna R, Foligné, Benoit, Ortega, Nathalie, Normand, Sylvain, Mertz, Kirsten, Sanmugalingam, Devika, Brault, Lea, Grandjean, Teddy, Lefrancais, Emma, Fallon, Padraic G, Quesniaux, Valérie, Peyrin-Biroulet, Laurent, Cathomas, Gieri, Junt, Tobias, Chamaillard, Mathias, Girard, Jean-Philippe, and Ryffel, Bernhard

Published
2013
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22. Additional file 2 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Author

Dessein, Rodrigue, Bauduin, Marvin, Grandjean, Teddy, Guern, Rémi Le, Figeac, Martin, Beury, Delphine, Faure, Karine, Faveeuw, Christelle, Benoit Guery, Gosset, Philippe, and Kipnis, Eric

Subjects
human activities
Abstract

Additional file 2 : Supplemental figure 2. Total bacterial 16SrDNA in the stool. Mice (n = 5) were treated by oral vancomycin (VAN) and colistin (CST) or not. Total 16srDNA expressed in relative quantity (fold-decrease) between VAN/CST and untreated controls (reference = 1).

Published
2020
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23. Additional file 5 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Author

Dessein, Rodrigue, Bauduin, Marvin, Grandjean, Teddy, Guern, Rémi Le, Figeac, Martin, Beury, Delphine, Faure, Karine, Faveeuw, Christelle, Benoit Guery, Gosset, Philippe, and Kipnis, Eric

Subjects
human activities
Abstract

Additional file 5 : Supplemental figure 5. Effects of oral non-absorbable antibiotics on hematopoietic factors and bone marrow monocyte/dendritic cell progenitors. (A) ELISA of hematopoietic factors in serum of mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not, (B) Flow cytometry of monocyte/DC progenitors in the bone marrow in mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not. For all experiments, group size 5 mice per group; results are shown as mean ± SD; *: p

Published
2020
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24. Additional file 6 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Author

Dessein, Rodrigue, Bauduin, Marvin, Grandjean, Teddy, Guern, Rémi Le, Figeac, Martin, Beury, Delphine, Faure, Karine, Faveeuw, Christelle, Benoit Guery, Gosset, Philippe, and Kipnis, Eric

Subjects
hemic and lymphatic diseases, embryonic structures, hemic and immune systems, biochemical phenomena, metabolism, and nutrition, human activities
Abstract

Additional file 6 : Supplemental figure 6. Effects of Flt3-Ligand on lung immune cell populations and on outcomes of lung infection. (A) Flow cytometry of monocyte/DC progenitors in the bone marrow of mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not, (B) Flow cytometry of immune cells from lungs of mice with 7-days oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not. For all experiments, group size 5 mice per group; results are shown as mean ± SD; *: p

Published
2020
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25. Additional file 3 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Author

Dessein, Rodrigue, Bauduin, Marvin, Grandjean, Teddy, Guern, Rémi Le, Figeac, Martin, Beury, Delphine, Faure, Karine, Faveeuw, Christelle, Benoit Guery, Gosset, Philippe, and Kipnis, Eric

Subjects
biochemical phenomena, metabolism, and nutrition
Abstract

Additional file 3 : Supplemental figure 3. Bacterial family as percentages of sequenced 16S rDNA in the lung and gut. Mice were treated or not by oral vancomycin (VAN), and colistin (CST) followed or not by fecal microbiota transplant (FMT) and infected or not by P. aeruginosa PAO1 (n = 2 per group).

Published
2020
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26. Additional file 4 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Author

Dessein, Rodrigue, Bauduin, Marvin, Grandjean, Teddy, Guern, Rémi Le, Figeac, Martin, Beury, Delphine, Faure, Karine, Faveeuw, Christelle, Benoit Guery, Gosset, Philippe, and Kipnis, Eric

Subjects
biochemical phenomena, metabolism, and nutrition, human activities
Abstract

Additional file 4 : Supplemental figure 4. Effects of oral non-absorbable antibiotics on lung and spleen immune cell populations. (A) Flow cytometry of immune cells from lung homogenates in mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not. (B) Flow cytometry of immune cells from spleen homogenates in mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not. All experiments, group size 5 mice per group, results are shown as mean ± SD; *: p

Published
2020
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27. Additional file 1 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Author

Dessein, Rodrigue, Bauduin, Marvin, Grandjean, Teddy, Guern, Rémi Le, Figeac, Martin, Beury, Delphine, Faure, Karine, Faveeuw, Christelle, Benoit Guery, Gosset, Philippe, and Kipnis, Eric

Abstract

Additional file 1 : Supplemental figure 1. Gating strategy for neutrophils, antigen-presenting cells, and the significant populations of lymphocytes in the lung. The percentages of natural killer (NK), invariant NKT cells (iNKT), and T Lc with a TCRgd were determined. Among APC, we identified alveolar macrophages (AM), inflammatory monocytes, patrolling monocytes, interstitial macrophages (IM), and conventional dendritic cells (cDC)1 and 2.

Published
2020
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30. Nouvelles fonctions pour les produits de l’opéron ami de Pseudomonas aeruginosa: Régulation de la virulence et du biofilm bactérien

Author

Clamens, Thomas, Rosay, T., Grandjean, Teddy, Hardouin, Julie, Cosette, Pascal, Dufour, Alain, Guery, Benoit, Bouffartigues, Emeline, Chevalier, Sylvie, Feuilloley, Marc, Lesouhaitier, Olivier, Laboratoire de Microbiologie Signaux et Microenvironnement (LMSM), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Polymères Biopolymères Surfaces (PBS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Plate-forme de Protéomique PISSARO, Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biotechnologie et Chimie Marines (LBCM), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Lesouhaitier, Olivier, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université de Brest (UBO)-Université de Bretagne Sud (UBS)-Institut Universitaire Européen de la Mer (IUEM)

Subjects
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

33. Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis

Author

Faure, Emmanuel, Faure, Karine, Figeac, Martin, Kipnis, Eric, Grandjean, Teddy, Dubucquoi, Sylvain, Villenet, Céline, Grandbastien, Bruno, Brabant, Gilles, Subtil, Damien, and Dessein, Rodrigue

Subjects
Adult, Pregnancy, Pregnancy Outcome, Observational Study, Homeostasis, Humans, Female, Pilot Projects, Vaginosis, Bacterial, Pregnancy Complications, Infectious, Immunity, Mucosal, Research Article
Abstract

Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcomes. A total of 402 vaginal self-samples from pregnant women in their first trimester were screened by Nugent score. In this population, we enrolled 23 pregnant women with BV but without APO, 5 pregnant women with BV and developing APO, 21 pregnant women with intermediate flora, and 28 random control samples from pregnant women without BV or APO. BV without APO in pregnant women was associated with 28-fold interleukin-8, 5-fold interleukin-10, and 40-fold interleukin-22 increases in expression compared to controls. BV associated with APO in pregnant women shared 4-fold increase in tumor necrosis factor, 100-fold decrease in interleukin-10, and no variation in interleukin-22 expressions compared to controls. Next-generation sequencing of vaginal microbiota revealed a shift from obligate anaerobic bacteria dominance in BV without APO pregnant women to Lactobacillus dominance microbiota in BV with APO. Our results show that the anti-inflammatory and mucosal homeostatic responses to BV may determine outcome of pregnancy in the setting of BV possibly through effects on the vaginal microbiota.

Published
2016

34. Additional file 1: of Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship

Author

Bortolotti, Perrine, Hennart, Benjamin, Thieffry, Camille, Jausions, Guillaume, Faure, Emmanuel, Grandjean, Teddy, Thepaut, Marion, Dessein, Rodrigue, Allorge, Delphine, Benoit Guery, Faure, Karine, Kipnis, Eric, Toussaint, Bertrand, and Gouellec, Audrey Le

Abstract

Metabolites produced by the Pa kynurenine pathway of a clinical strain. 1. Tryptophan (A), kynurenine (B), kynurenic acid (C), anthranilate (D), and 3-0H-kynurenine (E) concentrations in growth medium supernatants of a clinical strain as determined by UPLC-MS-MS. All data from one experiment in duplicate (PPTX 164Â kb)

Published
2016
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36. A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP 1 and TLR adaptors

Author

Imbert, Paul RC, primary, Louche, Arthur, additional, Luizet, Jean‐Baptiste, additional, Grandjean, Teddy, additional, Bigot, Sarah, additional, Wood, Thomas E, additional, Gagné, Stéphanie, additional, Blanco, Amandine, additional, Wunderley, Lydia, additional, Terradot, Laurent, additional, Woodman, Philip, additional, Garvis, Steve, additional, Filloux, Alain, additional, Guery, Benoit, additional, and Salcedo, Suzana P, additional

Published
2017
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37. The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence

Author

Clamens, Thomas, primary, Rosay, Thibaut, additional, Crépin, Alexandre, additional, Grandjean, Teddy, additional, Kentache, Takfarinas, additional, Hardouin, Julie, additional, Bortolotti, Perrine, additional, Neidig, Anke, additional, Mooij, Marlies, additional, Hillion, Mélanie, additional, Vieillard, Julien, additional, Cosette, Pascal, additional, Overhage, Joerg, additional, O’Gara, Fergal, additional, Bouffartigues, Emeline, additional, Dufour, Alain, additional, Chevalier, Sylvie, additional, Guery, Benoit, additional, Cornelis, Pierre, additional, Feuilloley, Marc G. J., additional, and Lesouhaitier, Olivier, additional

Published
2017
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38. Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: synthesis, binding studies and anti-adhesive properties

Author

Donnier-Maréchal, Marion, primary, Galanos, Nicolas, additional, Grandjean, Teddy, additional, Pascal, Yoann, additional, Ji, Ding-Kun, additional, Dong, Lei, additional, Gillon, Emilie, additional, He, Xiao-Peng, additional, Imberty, Anne, additional, Kipnis, Eric, additional, Dessein, Rodrigue, additional, and Vidal, Sébastien, additional

Published
2017
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39. Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship

Author

Bortolotti, Perrine, primary, Hennart, Benjamin, additional, Thieffry, Camille, additional, Jausions, Guillaume, additional, Faure, Emmanuel, additional, Grandjean, Teddy, additional, Thepaut, Marion, additional, Dessein, Rodrigue, additional, Allorge, Delphine, additional, Guery, Benoit P., additional, Faure, Karine, additional, Kipnis, Eric, additional, Toussaint, Bertrand, additional, and Le Gouellec, Audrey, additional

Published
2016
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42. Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

Author

Boukerb, Amine M., primary, Rousset, Audric, additional, Galanos, Nicolas, additional, Méar, Jean-Baptiste, additional, Thépaut, Marion, additional, Grandjean, Teddy, additional, Gillon, Emilie, additional, Cecioni, Samy, additional, Abderrahmen, Claire, additional, Faure, Karine, additional, Redelberger, David, additional, Kipnis, Eric, additional, Dessein, Rodrigue, additional, Havet, Stéphane, additional, Darblade, Benoit, additional, Matthews, Susan E., additional, de Bentzmann, Sophie, additional, Guéry, Benoit, additional, Cournoyer, Benoit, additional, Imberty, Anne, additional, and Vidal, Sébastien, additional

Published
2014
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43. CCL17 Production by Dendritic Cells Is Required for NOD1-mediated Exacerbation of Allergic Asthma

Author

Yahia, Saliha Ait, primary, Azzaoui, Imane, additional, Everaere, Laetitia, additional, Vorng, Han, additional, Chenivesse, Cécile, additional, Marquillies, Philippe, additional, Duez, Catherine, additional, Delacre, Myriam, additional, Grandjean, Teddy, additional, Balsamelli, Joanne, additional, Fanton d'Andon, Martine, additional, Fan, Ying, additional, Ple, Coline, additional, Werts, Catherine, additional, Boneca, Ivo Gomperts, additional, Wallaert, Benoit, additional, Chamaillard, Mathias, additional, and Tsicopoulos, Anne, additional

Published
2014
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45. Pancreatitis-Associated Protein Does Not Predict Disease Relapse in Inflammatory Bowel Disease Patients

Author

Nunes, Tiago, primary, Etchevers, Maria Josefina, additional, Sandi, Maria Jose, additional, Pinó Donnay, Susana, additional, Grandjean, Teddy, additional, Pellisé, Maria, additional, Panés, Julián, additional, Ricart, Elena, additional, Iovanna, Juan Lucio, additional, Dagorn, Jean-Charles, additional, Chamaillard, Mathias, additional, and Sans, Miquel, additional

Published
2014
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46. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

Author

Sedhom, Mamdouh A K, primary, Pichery, Mélanie, additional, Murdoch, Jenna R, additional, Foligné, Benoit, additional, Ortega, Nathalie, additional, Normand, Sylvain, additional, Mertz, Kirsten, additional, Sanmugalingam, Devika, additional, Brault, Lea, additional, Grandjean, Teddy, additional, Lefrancais, Emma, additional, Fallon, Padraic G, additional, Quesniaux, Valérie, additional, Peyrin-Biroulet, Laurent, additional, Cathomas, Gieri, additional, Junt, Tobias, additional, Chamaillard, Mathias, additional, Girard, Jean-Philippe, additional, and Ryffel, Bernhard, additional

Published
2012
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48. Antiadhesive Properties ofGlycoclusters against Pseudomonas aeruginosaLungInfection.

Author

Boukerb, Amine M., Rousset, Audric, Galanos, Nicolas, Méar, Jean-Baptiste, Thépaut, Marion, Grandjean, Teddy, Gillon, Emilie, Cecioni, Samy, Abderrahmen, Claire, Faure, Karine, Redelberger, David, Kipnis, Eric, Dessein, Rodrigue, Havet, Stéphane, Darblade, Benoit, Matthews, Susan E., de Bentzmann, Sophie, Guéry, Benoit, Cournoyer, Benoit, and Imberty, Anne

Published
2014
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49. Impact of the Timing of Antibiotic Administration on Digestive Colonization with Carbapenemase-Producing Enterobacteriaceaein a Murine Model

Author

Le Guern, Rémi, Grandjean, Teddy, Bauduin, Marvin, Figeac, Martin, Millot, Guillaume, Loquet, Aurore, Faure, Karine, Kipnis, Eric, and Dessein, Rodrigue

Abstract

While antibiotic use is a risk factor of carbapenemase-producing Enterobacteriaceae(CPE) acquisition, the importance of timing of antibiotic administration relative to CPE exposure remains unclear. In a murine model of gut colonization by New Delhi metallo-beta-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae, a single injection of clindamycin within at most 1 week before or after CPE exposure induced colonization persisting up to 100 days.

Published
2019
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