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9 results on '"Granger, Alice"'

1. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation

Author

Tan, Zhulin, primary, Ju, Xuan, additional, Wu, Hao, additional, Dong, Weitong, additional, Leung, Joyce C., additional, Hou, Xiaowen, additional, Lee, Heewon, additional, Granger, Alice, additional, Paolillo, Joshua M., additional, DiMeo, Susan V., additional, Chen, Chengsheng, additional, Wu, Linglin, additional, Lorenz, Jon C., additional, Sarvestani, Max, additional, Buono, Frederic, additional, Frutos, Rogelio, additional, Tampone, Thomas G., additional, Huang, Xiaojun, additional, Zhang, Gulin, additional, Wang, Yuwen, additional, Spinelli, Earl, additional, Lei, Zhen, additional, and Song, Jinhua J., additional

Published
2024
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4. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation

Author

Sieber, Joshua D., primary, Rodriguez, Sonia, additional, Frutos, Rogelio, additional, Buono, Frederic, additional, Zhang, Yongda, additional, Li, Ning, additional, Qu, Bo, additional, Premasiri, Ajith, additional, Li, Zhibin, additional, Han, Zhengxu S., additional, Xu, Yibo, additional, Byrne, Denis, additional, Haddad, Nizar, additional, Lorenz, Jon, additional, Grinberg, Nelu, additional, Kurouski, Dmitry, additional, Lee, Heewon, additional, Narayanan, Bikshandarkoil, additional, Nummy, Laurence, additional, Mulder, Jason, additional, Brown, Jack D., additional, Granger, Alice, additional, Gao, Joe, additional, Krawiec, Mariusz, additional, Williams, Zeena, additional, Pennino, Scott, additional, Song, Jinhua J., additional, Hossain, Azad, additional, Yee, Nathan K., additional, Busacca, Carl, additional, Roschangar, Frank, additional, Xin, Yanchao, additional, Mao, Zhantong, additional, Zhang, Xinzhu, additional, Hong, Yaping, additional, and Senanayake, Chris H., additional

Published
2018
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6. Structure elucidation and total synthesis of a unique group of trace impurities in Tipranavir® drug product

Author

Busacca, Carl A., primary, Campbell, Scot, additional, Saha, Anjan, additional, Lorenz, Jon C., additional, Grozinger, Karl, additional, Jones, Paul-James, additional, Grinberg, Nelu, additional, Shen, Sherry, additional, Lee, Heewon, additional, Qiu, Fenghe, additional, Granger, Alice, additional, Yuabova, Zhanna, additional, Norwood, Dan, additional, and Senanayake, Chris H., additional

Published
2005
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9. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF 3 -Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.

Author

Sieber JD, Rodriguez S, Frutos R, Buono F, Zhang Y, Li N, Qu B, Premasiri A, Li Z, Han ZS, Xu Y, Byrne D, Haddad N, Lorenz J, Grinberg N, Kurouski D, Lee H, Narayanan B, Nummy L, Mulder J, Brown JD, Granger A, Gao J, Krawiec M, Williams Z, Pennino S, Song JJ, Hossain A, Yee NK, Busacca C, Roschangar F, Xin Y, Mao Z, Zhang X, Hong Y, and Senanayake CH

Abstract

A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxiliary were achieved with good yield (97%) to enable recycling of the chiral auxiliary. An air-stable crystalline form of the final ligand was identified to enable isolation of the final ligand by crystallization to avoid chromatography. This synthetic route was applied to prepare up to 4 kg of the final ligand. The utility of this material was demonstrated in the asymmetric hydrogenation of trifluoromethyl vinyl acetate at 0.1 mol % Rh loading to access a surrogate for the pharmaceutically relavent chiral trifluoroisopropanol fragment in excellent yield and enantiomeric excess (98.6%).

Published
2018
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