Search

Your search keyword '"Grant, A. Cameron"' showing total 13 results
Start Over Author "Grant, A. Cameron"
13 results on '"Grant, A. Cameron"'

1. Donor–acceptor Stenhouse adduct functionalised polymer microspheres

Author

Justus P. Wesseler, Grant M. Cameron, Peter A. G. Cormack, and Nico Bruns

Subjects
Polymers and Plastics, Organic Chemistry, Bioengineering, Biochemistry
Abstract

DASA functionalised polymer microspheres as light-responsive species modulate polymer–solvent interactions.

Published
2023

2. Emulsion templating as a route to the release of organic micro- and nano- particles

Author

Grant, Neil Cameron

Subjects
615.19
Abstract

Many useful organic molecules such as drugs are poorly soluble in water. Novel ways of the deployment of these molecules are as stable nanodispersions. In our research we aim to produce a method for the creation of nanoparticles via a technique called emulsion-evaporation. These techniques include the creation of emulsions, ~olymerisation and A.,. .•••• ,. • freeze-drying. The production of these nanoparticles in-situ with templated porous polymers by these techniques was used. This avoids the problem of nanoparticle aggregation. These nanoparticles can be released into an aqueous medium by diffusing out of the porous scaffold or by a stimuli-sensitive trigger. We describe here the preparation of porous poly N-isopropylacrylamide. The swelling of the polymer and contraction above a solution temperature were explored for the uptake and release of polymeric colloids. The thesis discusses the application of readily soluble aqueous nanodispersions prepared by using a polyvinyl alcohol/sodium dodecyl sulphate (PVA/SDS) monolith prepared by emulsion templating. The monoliths can be prepared with the in-situ formation of drug nanoparticles which, readily solubilises the drug as nanodispersions. The thesis continues to explore stimuli as a method for the release of the organic nanoparticles: a chitosan based emulsion templated monolith was prepared which can release the formed nanoparticles from the scaffolds via control of pH. Finally, the use of a disulphide crosslinked polymer was explored for the release of organic nanoparticles. The particles could be released from the polymer by using a disulphide bond "cleaver" which degrades the polymer and thus releasing the internal organic nanoparticles. ii

Published
2011

4. Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration

Author

Caitriona O’Rourke, Charlotte Lee-Reeves, Rosemary AL Drake, Grant WW Cameron, A Jane Loughlin, and James B Phillips

Subjects
Biochemistry, QD415-436
Abstract

Neurodegenerative conditions remain difficult to treat, with the continuing failure to see therapeutic research successfully advance to clinical trials. One of the obstacles that must be overcome is to develop enhanced models of disease. Tissue engineering techniques enable us to create organised artificial central nervous system tissue that has the potential to improve the drug development process. This study presents a replicable model of neurodegenerative pathology through the use of engineered neural tissue co-cultures that can incorporate cells from various sources and allow degeneration and protection of neurons to be observed easily and measured, following exposure to neurotoxic compounds – okadaic acid and 1-methyl-4-phenylpyridinium. Furthermore, the technology has been miniaturised through development of a mould with 6 mm length that recreates the advantageous features of engineered neural tissue co-cultures at a scale suitable for commercial research and development. Integration of human-derived induced pluripotent stem cells aids more accurate modelling of human diseases, creating new possibilities for engineered neural tissue co-cultures and their use in drug screening.

Published
2017
Full Text
View/download PDF

5. Measuring the Statistical Capacity of Nations*

Author

Grant J. Cameron, Hai‐Anh H. Dang, Mustafa Dinc, James Foster, and Michael M. Lokshin

Subjects
Statistics and Probability, Economics and Econometrics, Statistics, Probability and Uncertainty, Social Sciences (miscellaneous)
Published
2021

11. Measuring the Statistical Capacity of Nations

Author

Mustafa Dinc, Grant James Cameron, Michael Lokshin, James Stephen Foster, and Hai-Anh H. Dang

Subjects
Sustainable development, Index (economics), Computer science, 05 social sciences, Technical standard, Socioeconomic development, Environmental economics, Good governance, Conceptual framework, Data quality, 0502 economics and business, 050207 economics, International development, 050205 econometrics
Abstract

The international development community has used the World Bank's Statistical Capacity Index since its inception in 2004. The Sustainable Development Goals create new challenges for national statistical systems to produce high-quality and internationally comparable data. This paper reviews measurement methodologies, posits desired attributes, and presents theoretical and empirical frameworks for the new, improved index to monitor progress in the statistical capacity of nations. The paper illustrates the properties of the updated index with global data from 2016.

Published
2019

13. FIELD EXPERIMENTS SHOW THAT ACOUSTIC PINGERS REDUCE MARINE MAMMAL BYCATCH IN THE CALIFORNIA DRIFT GILL NET FISHERY

Author

Jay Barlow and Grant A. Cameron

Subjects
biology, Zalophus californianus, Swordfish, Fishing, Cetacea, Delphinus delphis, Aquatic Science, biology.organism_classification, Fishery, Bycatch, Marine mammal, biology.animal, Controlled experiment, Ecology, Evolution, Behavior and Systematics
Abstract

A controlled experiment was carried out in 19961997 to determine whether acoustic deterrent devices (pingers) reduce marine mammal bycatch in the California drift gill net fishery for swordfish and sharks. Using Fisher’s exact test, bycatch rates with pingers were significantly less for all cetacean species combined (P < 0.001) and for all pinniped species combined (P = 0.003). For species tested separately with this test, bycatch reduction was statistically significant for shortbeaked common dolphins (P = 0.001) and California sea lions (P = 0.02). Bycatch reduction is not statistically significant for the other species tested separately, but sample sizes and statistical power were low, and bycatch rates were lower in pingered nets for six of the eight other cetacean and pinniped species. A log-linear model relating the mean rate of entanglement to the number of pingers deployed was fit to the data for three groups: short-beaked common dolphins, other cetaceans, and pinnipeds. For a net with 40 pingers, the models predict approximately a 12fold decrease in entanglement for short-beaked common dolphins, a 4-fold decrease for other cetaceans, and a 3-fold decrease for pinnipeds. No other variables were found that could explain this effect. The pinger experiment ended when regulations were enacted to make pingers mandatory in this fishery.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results