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5. 6. Internet

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

6. Index

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

8. 7. Food

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

10. Resources

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

11. 4. Stealing

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

12. Contents

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

14. Title Page, Copyright

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

15. 1. Introduction

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

16. 5. Sex

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

17. Preface

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

18. 3. Gambling

Author

Grant, Jon E., Odlaug, Brian L., and Chamberlain, Samuel R.

Published
2016

22. Neurobiology of subtypes of trichotillomania and skin picking disorder

Author

Grant, Jon E, Bethlehem, Richard AI, Chamberlain, Samuel R, Peris, Tara S, Ricketts, Emily J, O’Neill, Joseph, Dougherty, Darin D, Stein, Dan, Lochner, Christine, Woods, Douglas W, Piacentini, John, and Keuthen, Nancy J

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Clinical Sciences, Psychology, Prevention, Neurosciences, Mental Health, Clinical Research, Good Health and Well Being, Adult, Humans, Female, Trichotillomania, Brain, Impulsive Behavior, Comorbidity, skin picking disorder, imaging, subtypes, neurobiology, Psychiatry, Clinical sciences, Biological psychology
Abstract

BackgroundTrichotillomania (TTM) and skin picking disorder (SPD) are common and often debilitating mental health conditions, grouped under the umbrella term of body-focused repetitive behaviors (BFRBs). Recent clinical subtyping found that there were three distinct subtypes of TTM and two of SPD. Whether these clinical subtypes map on to any unique neurobiological underpinnings, however, remains unknown.MethodsTwo hundred and fifty one adults [193 with a BFRB (85.5% [n = 165] female) and 58 healthy controls (77.6% [n = 45] female)] were recruited from the community for a multicenter between-group comparison using structural neuroimaging. Differences in whole brain structure were compared across the subtypes of BFRBs, controlling for age, sex, scanning site, and intracranial volume.ResultsWhen the subtypes of TTM were compared, low awareness hair pullers demonstrated increased cortical volume in the lateral occipital lobe relative to controls and sensory sensitive pullers. In addition, impulsive/perfectionist hair pullers showed relative decreased volume near the lingual gyrus of the inferior occipital-parietal lobe compared with controls.ConclusionsThese data indicate that the anatomical substrates of particular forms of BFRBs are dissociable, which may have implications for understanding clinical presentations and treatment response.

Published
2023

26. Neural basis of associative learning in Trichotillomania and skin-picking disorder

Author

Dougherty, Darin D, Peters, Amy T, Grant, Jon E, Peris, Tara S, Ricketts, Emily J, Migó, Marta, Chou, Tina, O'Neill, Joseph, Stein, Dan J, Lochner, Christine, Keuthen, Nancy, Piacentini, John, and Deckersbach, Thilo

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, Basic Behavioral and Social Science, Brain Disorders, Clinical Research, Behavioral and Social Science, Mental Health, Underpinning research, 1.1 Normal biological development and functioning, 1.2 Psychological and socioeconomic processes, Mental health, Neurological, Adolescent, Adult, Bayes Theorem, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Trichotillomania, Young Adult, Skin-picking disorder, Associative learning, Cognitive flexibility, Functional neuroimaging, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Disorders such as Trichotillomania (TTM) and skin-picking disorder (SPD) are associated with reduced flexibility and increased internally focused attention. While the basal ganglia have been hypothesized to play a key role, the mechanisms underlying learning and flexible accommodation of new information is unclear. Using a Bayesian Learning Model, we evaluated the neural basis of learning and accommodation in individuals with TTM and/or SPD. Participants were 127 individuals with TTM and/or SPD (TTM/SPD) recruited from three sites (age 18-57, 84% female) and 26 healthy controls (HC). During fMRI, participants completed a shape-button associative learning and reversal fMRI task. Above-threshold clusters were identified where the Initial Learning-Reversals BOLD activation contrast differed significantly (p

Published
2022

33. Identifying subtypes of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder using mixture modeling in a multicenter sample

Author

Grant, Jon E, Peris, Tara S, Ricketts, Emily J, Lochner, Christine, Stein, Dan J, Stochl, Jan, Chamberlain, Samuel R, Scharf, Jeremiah M, Dougherty, Darin D, Woods, Douglas W, Piacentini, John, and Keuthen, Nancy J

Subjects
Clinical and Health Psychology, Psychology, Clinical Research, Neurosciences, Mental Health, Mental health, Adult, Humans, Trichotillomania, Skin picking disorder, Subtypes, Classification, Treatment, Mixture modeling, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

Body-focused repetitive behavior disorders (BFRBs) include Trichotillomania (TTM; Hair pulling disorder) and Excoriation (Skin Picking) Disorder (SPD). These conditions are prevalent, highly heterogeneous, under-researched, and under-treated. In order for progress to be made in optimally classifying and treating these conditions, it is necessary to identify meaningful subtypes. 279 adults (100 with TTM, 81 with SPD, 40 with both TTM and SPD, and 58 controls) were recruited for an international, multi-center between-group comparison using mixture modeling, with stringent correction for multiple comparisons. The main outcome measure was to examine distinct subtypes (aka latent classes) across all study participants using item-level data from gold-standard instruments assessing detailed clinical measures. Mixture models identified 3 subtypes of TTM (entropy 0.98) and 2 subtypes of SPD (entropy 0.99) independent of the control group. Significant differences between these classes were identified on measures of disability, automatic and focused symptoms, perfectionism, trait impulsiveness, and inattention and hyperactivity. These data indicate the existence of three separate subtypes of TTM, and two separate subtypes of SPD, which are distinct from controls. The identified clinical differences between these latent classes may be useful to tailor future treatments by focusing on particular traits. Future work should examine whether these latent subtypes relate to treatment outcomes, or particular psychobiological findings using neuroimaging techniques.

Published
2021

36. Identifying the most important research, policy and practice questions for substance use, problematic alcohol use and behavioural addictions in autism (SABA-A): A priority setting partnership

Author

Sinclair, Julia M.A., Aslan, Betul, Agabio, Roberta, Anilkumar, Amith, Brosnan, Mark, Day, Ed, Dowling, Nicki A., Flood, Chelsey, Grant, Jon E., Halliday, Robyn, Hofvander, Björn, Howes, Leesa, Moseley, Rachel, Myers, Bronwyn, O'Connor, Vincent, Shaya, Gabriel, Thomas, Shane, Robinson, Janine, and Chamberlain, Samuel R.

Published
2023
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50. Examining the unique relationships between problematic use of the internet and impulsive and compulsive tendencies: network approach

Author

Liu, Chang, primary, Rotaru, Kristian, additional, Ren, Lei, additional, Chamberlain, Samuel R., additional, Christensen, Erynn, additional, Brierley, Mary-Ellen, additional, Richardson, Karyn, additional, Lee, Rico S. C., additional, Segrave, Rebecca, additional, Grant, Jon E., additional, Kayayan, Edouard, additional, Hughes, Sam, additional, Fontenelle, Leonardo F., additional, Lowe, Amelia, additional, Suo, Chao, additional, Freichel, René, additional, Wiers, Reinout W., additional, Yücel, Murat, additional, and Albertella, Lucy, additional

Published
2024
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