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3. Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial.

Author

Dianti, Jose, Fard, Samira, Wong, Jenna, Chan, Timothy, Del Sorbo, Lorenzo, Fan, Eddy, Amato, Marcelo, Granton, John, Burry, Lisa, Reid, W, Zhang, Binghao, Ratano, Damian, Keshavjee, Shaf, Slutsky, Arthur, Brochard, Laurent, Ferguson, Niall, and Goligher, Ewan

Subjects
Diaphragm-protective ventilation, Hypoxemic respiratory failure, Lung-protective ventilation, Mechanical ventilation, Diaphragm, Humans, Lung, Positive-Pressure Respiration, Respiration, Artificial, Respiratory Insufficiency
Abstract

BACKGROUND: Insufficient or excessive respiratory effort during acute hypoxemic respiratory failure (AHRF) increases the risk of lung and diaphragm injury. We sought to establish whether respiratory effort can be optimized to achieve lung- and diaphragm-protective (LDP) targets (esophageal pressure swing - 3 to - 8 cm H2O; dynamic transpulmonary driving pressure ≤ 15 cm H2O) during AHRF. METHODS: In patients with early AHRF, spontaneous breathing was initiated as soon as passive ventilation was not deemed mandatory. Inspiratory pressure, sedation, positive end-expiratory pressure (PEEP), and sweep gas flow (in patients receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO)) were systematically titrated to achieve LDP targets. Additionally, partial neuromuscular blockade (pNMBA) was administered in patients with refractory excessive respiratory effort. RESULTS: Of 30 patients enrolled, most had severe AHRF; 16 required VV-ECMO. Respiratory effort was absent in all at enrolment. After initiating spontaneous breathing, most exhibited high respiratory effort and only 6/30 met LDP targets. After titrating ventilation, sedation, and sweep gas flow, LDP targets were achieved in 20/30. LDP targets were more likely to be achieved in patients on VV-ECMO (median OR 10, 95% CrI 2, 81) and at the PEEP level associated with improved dynamic compliance (median OR 33, 95% CrI 5, 898). Administration of pNMBA to patients with refractory excessive effort was well-tolerated and effectively achieved LDP targets. CONCLUSION: Respiratory effort is frequently absent  under deep sedation but becomes excessive when spontaneous breathing is permitted in patients with moderate or severe AHRF. Systematically titrating ventilation and sedation can optimize respiratory effort for lung and diaphragm protection in most patients. VV-ECMO can greatly facilitate the delivery of a LDP strategy. TRIAL REGISTRATION: This trial was registered in Clinicaltrials.gov in August 2018 (NCT03612583).

Published
2022

4. Feasibility of Internet-Based Health-Related Quality of Life Data Collection in a Large Patient Cohort

Author

Bhinder, Sacha, Chowdhury, Noori, Granton, John, Krahn, Murray, Tullis, D Elizabeth, Waddell, Thomas K, and Singer, Lianne G

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundPatient registries are commonly used to track survival and medical outcomes in large cohorts. However, large-scale collection of health-related quality of life (HRQOL) data is more challenging because such data must be collected directly from patients. Internet-based HRQOL questionnaires are a potential solution, allowing home data collection with immediate storage in a central database. ObjectivesOur objectives were to investigate the sociodemographic predictors of Internet use and willingness to convey HRQOL information over the Internet in a Canadian tertiary care patient population and to determine whether Internet use patterns of tertiary care patients differ from those of the general Canadian population. Additionally, we sought to identify the success of home completion of Internet-based HRQOL questionnaires, as well as factors hindering home completion. MethodsWe surveyed 644 patients at the Toronto General and St. Michael’s Hospitals from November 2003 through July 2006 within a prospective, longitudinal cohort study of HRQOL in patients with lung disease or lung transplants. Using multiple logistic regression, we assessed patient age, gender, rurality, marital status, and employment or education status as potential sociodemographic predictors of having an Internet-accessible home computer, using email at least weekly, and willingness to complete a quality of life questionnaire over the Internet. Patients electing to complete questionnaires over the Internet were followed from September 2005 through March 2008 to assess completion of HRQOL questionnaires from home, identify barriers for noncompletion, and determine sociodemographic predictors for home completion. ResultsOf the 644 patients, the median age was 51 years, with a similar number of males and females. Most were urban Ontario residents, were unemployed, and were married or in a common-law relationship. Having an Internet-accessible home computer was reported by 79.7% (513/644) of patients and use of email at least weekly by 66.5% (414/623) of patients. A majority of patients (57.1% 368/644) were willing to complete HRQOL questionnaires over the Internet via an emailed link. Of the participating 644 patients, 368 elected to complete future questionnaires from home and, as part of a gradual roll-out of the home HRQOL questionnaire, 211 were sent emails inviting them to do so. Of the invited patients, 78% (165/211) completed at least one questionnaire from home. The most common reason for noncompletion was a lack of or an inability to find time to complete the questionnaire. No statistically significant sociodemographic predictors of Internet use were associated with completion or noncompletion of questionnaires from home. ConclusionsHome, Internet-based HRQOL assessment is feasible in tertiary care patient populations with a high predicted rate of Internet usage based on sociodemographic parameters. A large minority of patients were unwilling or unable to take part in home HRQOL assessments indicating that alternative methods of data collection are still required. However, the majority of patients electing to complete home HRQOL assessments went on to do so over the Internet.

Published
2010
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11. The authors reply

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Martin Carrier, François, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Duquet-Deblois, Estel, Noël-Hunter, Monia, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Tapss, Danielle, Toupin, Guylaine, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Williams, Virginie, Lainer Palacios, Julia, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Lizotte, Patricia, Rochwerg, Bram, Millen, Tina, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Boyd, Tracy, Hunt, Miranda, Mele, Tina, Bentall, Tracey, ElKhatib, Chadia, Shahin, Jason, Khwaja, Kosar, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Mehta, Sangeeta, Detsky, Michael, Shah, Sumesh, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, Bharti, Dalisha, Perez, Adic, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Hewer, Tayne, Thompson, Patrica, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Clarke, France, Copland, Mary, Matic, Karlo, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Abdelhady, Hesham, Romagnuolo, Tina, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, McConnochie, Rachael, Simmonds, Catherine, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Eden, Amie, France, Dawn, Buehner, Ulrike, Erin Williams, Katallah Kramer, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Goodson, Jennifer, Martynoga, Robert, Byrne, Kelly, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Sol Cruz, Raulle, Sol Cruz, Rhoze, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Tirupakuzhi Vijayaraghavan, Bharath Kumar, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
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14. Catheter-associated superior vena cava syndrome

Author

Morriello, Florence, Brown, Andrew, Granton, John, and Bonta, Mark

Subjects
Superior vena cava syndrome -- Risk factors -- Prevention, Colon cancer -- Development and progression -- Care and treatment, Colectomy -- Complications and side effects, Central venous catheters -- Usage -- Complications and side effects, Ostomy -- Risk factors -- Prevention, Health
Abstract

A 53-year-old man presented to the emergency department with a 3-week history of throbbing headaches, dizziness and cyanosis, with worsening symptoms over the previous 7 days. The patient had a [...]

Published
2023
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15. IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Carrier, François Martin, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Duquet-Deblois, Estel, Noël-Hunter, Monia, Tapss, Danielle, Toupin, Guylaine, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Williams, Virginie, Lainer Palacios, Julia, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Rochwerg, Bram, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Mele, Tina, Shahin, Jason, Khwaja, Kosar, Mehta, Sangeeta, Detsky, Michael, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Wood, Gordon, Ovakim, Daniel, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lizotte, Patricia, Millen, Tina, Boyd, Tracy, Hunt, Miranda, Bentall, Tracey, ElKhatib, Chadia, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Shah, Sumesh, Bharti, Dalisha, Perez, Adic, Hewer, Tayne, Thompson, Patrica, Clarke, France, Copland, Mary, Matic, Karlo, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Abdelhady, Hesham, Romagnuolo, Tina, Baig, Nadia, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Buehner, Ulrike, Kramer, Katallah, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Martynoga, Robert, Byrne, Kelly, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, McConnochie, Rachael, Simmonds, Catherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Eden, Amie, France, Dawn, Williams, Erin, Goodson, Jennifer, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Cruz, Raulle Sol, Cruz, Rhoze Sol, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Vijayaraghavan, Bharath Kumar Tirupakuzhi, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
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23. Evaluation and management of patients with chronic thromboembolic pulmonary hypertension - consensus statement from the ISHLT

Author

de Perrot, Marc, Gopalan, Deepa, Jenkins, David, Lang, Irene M., Fadel, Elie, Delcroix, Marion, Benza, Raymond, Heresi, Gustavo A., Kanwar, Manreet, Granton, John T., McInnis, Micheal, Klok, Frederikus A., Kerr, Kim M., Pepke-Zaba, Joanna, Toshner, Mark, Bykova, Anastasia, D’Armini, Andrea M., Robbins, Ivan M., Madani, Michael, McGiffin, David, Wiedenroth, Christoph B., Mafeld, Sebastian, Opitz, Isabelle, Mercier, Olaf, Uber, Patricia A., Frantz, Robert P., and Auger, William R.

Published
2021
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35. Overnight staffing in Canadian neonatal and pediatric intensive care units

Author

Maratta, Christina, primary, Hutchison, Kristen, additional, Nicoll, Jessica, additional, Bagshaw, Sean M., additional, Granton, John, additional, Kirpalani, Haresh, additional, Stelfox, Henry Thomas, additional, Ferguson, Niall, additional, Cook, Deborah, additional, Parshuram, Christopher S., additional, and Moore, Gregory P., additional

Published
2023
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38. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study

Author

Wallace, Sophie, Thompson, Bruce, Ellis, Mathew, Borg, Brigette, Kerridge, Ross K, Douglas, Jeanene, Brannan, John, Pretto, Jeff, Godsall, Guy, Beauchamp, Nicola, Allen, Sandra, Kennedy, Ann, Wright, Ewan, Malherbe, Johan, Ismail, Hilmy, Riedel, Bernhard, Melville, Andrew, Sivakumar, Harry, Murmane, Andrew, Kenchington, Kay, Kirabiyik, Yesim, Gurunathan, Usha, Stonell, Chris, Brunello, Kate, Steele, Katherine, Tronstad, Oystein, Masel, Philip, Dent, Annette, Smith, Emma, Bodger, Alanna, Abolfathi, Miriam, Sivalingam, Pal, Hall, Adrian, Painter, Thomas W, Macklin, Simon, Elliott, Adrian, Carrera, Anna Maria, Terblanche, Nico CS, Pitt, Simon, Samuel, Joanne, Wilde, Chris, Leslie, Kate, MacCormick, Andrew, Bramley, David, Southcott, Anne Marie, Grant, John, Taylor, Hugh, Bates, Samantha, Towns, Miriam, Tippett, Anna, Marshall, Fiona, Mazer, C David, Kunasingam, Janarthanee, Yagnik, Anmol, Crescini, Charmagne, Yagnik, Sanjay, McCartney, Colin JL, Somascanthan, Priya, Choi, Stephen, Flores, Kathrina, Au, Shelly, Beattie, W Scott, Karkouti, Keyvan, Clarke, Hance A, Jerath, Angela, McCluskey, Stuart A, Wasowicz, Marcin, Day, Lauren, Pazmino-Canizares, Janneth, Oh, Paul, Belliard, Rene, Lee, Leanna, Dobson, Karen, Chan, Vincent, Brull, Richard, Ami, Noam, Stanbrook, Matthew, Hagen, Katherine, Campbell, Douglas, Short, Timothy, Van Der Westhuizen, Joreline, Higgie, Kushlin, Lindsay, Helen, Jang, Ryan, Wong, Chris, McAllister, Davina, Ali, Marlynn, Kumar, Jonathan, Waymouth, Ellen, Kim, Chang Joon, Dimech, Julian, Lorimer, Michael, Tai, Joyce, Miller, Reuben, Sara, Rachel, Collingwood, Andrew, Olliff, Sue, Gabriel, Sharon, Houston, Helen, Dalley, Paul, Hurford, Sally, Hunt, Anna, Andrews, Lynn, Navarra, Leanlove, Jason-Smith, Adelaide, Thompson, Helen, McMillan, Natalie, Back, Geraldine, Lum, Mark, Martin, Daniel, James, Sarah, Filipe, Helder, Pinto, Manuel, Kynaston, Stephen, Phull, Mandeep, Beilstein, Christian, Bodger, Pheobe, Everingham, Kirsty, Hu, Ying, Niebrzegowska, Edyta, Corriea, Carmen, Creary, Thais, Januszewska, Marta, Ahmad, Tahania, Whalley, Jan, Haslop, Richard, McNeil, Jane, Brown, Alistair, MacDonald, Neil, Pakats, Mari Liis, Greaves, Kathryn, Jhanji, Shaman, Raobaikady, Ravishanar, Black, Ethel, Rooms, Martin, Lawrence, Helen, Koutra, Maria, Pirie, Katrina, Gertsman, Michelle, Jack, Sandy, Celinski, Michael, Levett, Denny, Edwards, Mark, Salmon, Karen, Bolger, Clare, Loughney, Lisa, Seaward, Leanne, Collins, Hannah, Tyrell, Bryony, Tantony, Natasha, Golder, Kim, Ackland, Gareth L, Stephens, RCM, Gallego-Paredes, Laura, Reyes, Anna, Gutierrez del Arroyo, Ana, Raj, Ashok, Lifford, Rhiannon, Melo, Magda, Mamdani, Muhammad, Hillis, Graham, Wijeysundera, Harindra C, Wijeysundera, Duminda N, Pearse, Rupert M, Shulman, Mark A, Abbott, Tom E F, Torres, Elizabeth, Ambosta, Althea, Croal, Bernard L, Granton, John T, Thorpe, Kevin E, Grocott, Michael P W, Farrington, Catherine, Myles, Paul S, and Cuthbertson, Brian H

Published
2018
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41. Myeloid angiogenic cells exhibit impaired migration, reduced expression of endothelial markers, and increased apoptosis in idiopathic pulmonary arterial hypertension

Author

Zhang, Qiuwang, Zucco, Liana, Toshner, Mark, Morrell, Nicholas W., Granton, John, Stewart, Duncan J., and Kutryk, Michael J.B.

Subjects
Cellular therapy -- Methods, Endothelium -- Health aspects -- Physiological aspects, Pulmonary hypertension -- Care and treatment -- Health aspects -- Physiological aspects, Biological sciences
Abstract

Idiopathic pulmonary arterial hypertension (IPAH) is a rare and devastating condition. There is no known cure for IPAH, and current treatment options are not always effective. Autologous myeloid angiogenic cells (MACs) have been explored as a novel therapy for IPAH, but preliminary data from clinical trials show limited beneficial effects. A complete understanding of IPAH MAC function remains elusive. This study was designed to comprehensively compare cell function between IPAH MACs and healthy control MACs. MACs were procured through the culture of peripheral blood mononuclear cells in endothelial selective medium for 7 days. Compared with healthy MACs, IPAH MACs exhibited (1) significantly lower levels of endothelial markers as shown by fluorescence microscopy; (2) a markedly higher rate of apoptosis under both normal culture condition and serum starvation as shown by the TUNEL assay; (3) significantly decreased migration towards vascular endothelial growth factor as shown by a modified Boyden chamber migration assay; and (4) similar vascular endothelial growth factor and endothelial nitric oxide synthase mRNA levels as shown by reverse transcription quantitative PCR. In conclusion, various aspects of IPAH MAC function are impaired. To achieve greater therapeutic benefits, pharmacologic and (or) genetic manipulations to improve IPAH MAC function, particularly to promote cell survival and migration, are warranted. Key words: cell therapy, idiopathic pulmonary artery hypertension, myeloid angiogenic cell, cell apoptosis, cell migration, gene expression. L'hypertension arterielle pulmonaire idiopathique (HTAPI) est une maladie rare et foudroyante. On ne lui connait pas de traitement curatif et les options therapeutiques actuelles ne sont pas toujours efficaces. Nous avons explore la question des cellules myeloides angiogeniques (CMA) autologues en tant que nouveau traitement de l'HTAPI, mais les donnees preliminaires issues d'essais cliniques montrent peu d'effets benefiques. Une comprehension complete du fonctionnement des CMA dans l'HTAPI demeure hors de portee nous echappe toujours. Cette etude a ete concue en vue de comparer en detail le fonctionnement des cellules entre les CMA dans l'HTAPI et des CMA temoins de sujets en bonne sante. Nous avons obtenu les CMA par la culture de cellules mononucleaires de sang peripherique dans un milieu selectif pour l'endothelium pendant 7 jours. Comparativement aux CMA en bonne sante, les CMA dans l'HTAPI presentaient les elements suivants : (1) des taux nettement moins eleves de marqueurs endotheliaux tels que deceles en microscopie par fluorescence; (2) des taux d'apoptose nettement plus importants en cultures tant avec conditionnement normal que privation de serum tels que deceles a l'aide de l'epreuve de TUNEL; (3) une diminution notable de la migration vers le facteur de croissance de l'endothelium vasculaire (ou VEGF pour << vascular endothelial growth factor >>) avec l'epreuve de migration en chambre de Boyden et (4) des taux semblables d'ARNm de VEGF et d'oxyde nitrique synthase endotheliale mesures par technique de PCR quantitatif avec transcriptase inverse. En conclusion, differents aspects du fonctionnement des CMA sont affectes dans l'HTAPI. Des experiences pharmacologiques ou genetiques visant l'amelioration du fonctionnement des CMA dans l'HTAPI sont necessaires en vue d'obtenir des bienfaits therapeutiques plus importants, particulierement en vue de faciliter la survie et la migration des cellules. [Traduit par la Redaction] Mots-cles : therapie cellulaire, hypertension arterielle pulmonaire idiopathique, cellules myeloides angiogeniques, apoptose cellulaire, migration cellulaire, expression genique., Introduction Pulmonary arterial hypertension (PAH) is a rare disease, with an estimated prevalence of 10-50 per million people (Hoeper and Gibbs 2014). The disease is characterized by pathological changes in [...]

Published
2019
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44. The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia

Author

Arnold, Donald M., Lauzier, Francois, Albert, Martin, Williamson, David, Li, Na, Zarychanski, Ryan, Doig, Chip, McIntyre, Lauralyn, Freitag, Andreas, Crowther, Mark, Saunders, Lois, Clarke, France, Bellomo, Rinaldo, Qushmaq, Ismael, Lopes, Renato D., Heels‐Ansdell, Diane, Webert, Kathryn, Cook, Deborah, Hall, Rick, Rocker, Graeme, Julien, Lisa, Wright, Debbie, Roy, Caroline, Theriault, Judy, Pleasance, Susan, Meade, Maureen, Hand, Lori, Wynne, Christine, Duffett, Mark, Kho, Michelle, Zytaruk, Nicole, Granton, John, Matte, Andrea, Farias, Paulina, Chu, Leslie, Brockest, Nancy, Go, Stephanie, McGrath‐Chong, Margaret, Dennis, Madison, Lipkus, Marc, Stern, Emily, Albert, Ryan, Langevin, Stephan, Turgeon, Alexis F, Tremblay, Marie‐Claude, Blais, Martine, Beauparlant, Maxime, Asselin, Julie, Gagne, Chantal, Thibodeau, Marie, Poirier, Germain, Spearson, Sandrine, Neas, Isabelle, Pagliarello, Joe, Hébert, Paul, Watpool, Irene, McArdle, Tracy, Gaudert, Claude, Marchand, Paule, Davidson, Carson, Lewis, Mary‐Jo, Murphy, Erin, Foxall, Julia, Skrobik, Yoanna, Harvey, Johanne, Chitu, Stefania, Williams, Virginie, Sirois, Carole, Nadon, Carole, Dolle, Stephanie, Gosselin, Audrey‐Anne, Deroy, Patrice, Mehta, Geeta, Shah, Sumesh, Ethier, Cheryl, Tirgari, Sam, Steinberg, Lindsay, McDonald, Rod, Sivanantham, Vidhya, Bandayrel, Kristofer, Quittnat Pelletier, Friederike, Kramer‐Kile, Marnie, Brown, Maedean, Kim, Scott, Fowler, Rob, Marinoff, Nicole, Code, Karen, Bojilov, Boris, Parsotam, Derek, Marshall, John, Smith, Orla, Fry, Beth, Porretta, Kerri, Lee, Yoon, Morrissey, Jeanna, Wen, Victoria, Muscedere, John, Hunt, Miranda, Fleury, Susan, Godfrey, Nicole, Hammond, Sharlene, Mann, Elizabeth, Myers, Monica, Robinson, Amber, Griesdale, Donald, Chittock, Dean, Dhingra, Vinay, Foster, Denise, Gardner, Maureen, Logie, Susan, Autio, Roger, Davies, Dara, Ganz, Pia, Smith, Laurie, Dodek, Peter, Alcuaz, Victoria, Ashley, Betty Jean, Mans, Sheilagh, Ferguson, Niall, Stevenson, James, Elman, Joel, Karachi, Timothy, Millen, Tina, Tkaczyk, Andrea, Jacka, Mike, Irwin, Marleen, Chan, Carmen, Sonnema, Leeca, Marsh, Kelly, Maurer, Jennifer, Kreidl, Tamara, Varden, Candice, Kinjerski, Carey, Doig, Christopher, Ruddell, Stacy, Knox, Linda, Wilson, Crystal, Champagne, Kevin, Wood, Gordon, Auld, Fiona, Atkins, Leslie, Paunovic, Bojan, Marten, Nicole, Wiebe, Kym, McDonald, Ellen, Keenan, Sean, Reynolds, Steven, Svetik, Miroslav, Van Osch, Mary, Kutsogiannis, Jim, Thompson, Patrica, Whalen, Norine, Lellouche, Francois, Ferland, Marie‐Claude, Dussault, Patrick, Jacob, Caroline, Morneau, Marie‐Eve, Laberge, Nancy, Khwaja, Kosar, Banici, Laura, Havell, Lena, Lesur, Olivier, Lamontagne, Francois, Proulx, Sandra, Hollinger, Gerald, Shende, Vasanti, Belcastro, Vanessa, Plaxton, Bill, Foss, Anders, Eisenstat, Jonathan, Doerle, Tammy, Sharpe, Michael, Madady, Mona, Cooper, Jamie, Davies, Andrew, Vallance, Shirley, Weatherburn, Cindy, Board, Jasmin, Bennett, Victoria, Finfer, Simon, Ramakrishnan, Naresh, Bird, Simon, Potter, Julie, O’Connor, Anne, Ankers, Susan, Cade, Jack, Barge, Deborah, Caf, Tania, Howe, Belinda, Eastwood, Glenn, Peck, Leah, Goldsmith, Donna, O’Sullivan, Kim, Ernest, David, Radford, Sam, Whitfield, Ann, Cross, Anthony, Eliott, Suzanne, Sidhu, Jaspreet, Mercer, Inga, Hamilton, Angela, Botha, John, Vuat, Jodi, Allsop, Sharon, Fowler, Nina, Crozier, Tim, Barrett, Jonathan, Wright, Chris, Galt, Pauline, Culhane, Carly, Ioannidis, Rebecca, Burton, Sue, Reily, Marnie, Weeraratna, Cyveen, Seppelt, Ian, Weisbrodt, Leonie, Bond, Robyn, Hospital, Nepean, Rivett, Justine, O’Connor, Stephanie, Poole, Alex, Woolfe, Clive, Rajbhandari, Dorrilyn, Rees, Caitlin, Edington, John, Fletcher, Jason, Smith, Julie, Boschert, Catherine, Reece, Graham, Sara, Treena, Nand, Kiran, Bersten, Andrew, Gallus, Alex, Matheson, Elisha, O’Callaghan, Margie, Orford, Neil, Elderkin, Tania, Fraser, Melissa, Bone, Allison, Salerno, Tania, Kinmonth, Anne, Arora, Subhash, O’Bree, Bridget, Shepherd, Katherine, –Quinn, Alan, Sterba, Martin, Johnson, Bronwyn Ruth, Xu, Renee, Hill, Francisco, Ramadoss, Rajaram, Wood, Josette, da Rocha, Marcelo Garcia, Kramer, Andréa, Hädrich, Martha, Brandao, Nilton, Teixeira, Cassiano, Roehrig, Cíntia, Zeni, Juliana, da Silva, Suzana Alves, Filho, Rubens Costa, Correa, Renato, Moreira, Alves, Gomes, Plínio N., Biondi, Rodrigo, Berwanger, Otavio, Romano, Edson, Buehler, Anna Maria, Guimarães, Helio Penna, Truffa, Adriano, Nakamura, Rosana, Barbosa, Lillian Mazza, Brennick, Jean, Bassi, Sawsan, Alsultan, Mohammed, Arabi, Yaseen, Brits, Riette, Alhashemi, Jamal, Shalabi, Sanaa, Mandourah, Yasser, Shaikh, Nadeem, Al‐Hazmi, Manal, Ali Al‐Azem, M., Wyngaard, Trevor, Smithson, Barbara, Vlahakis, Nicholas E, Meade, Laurie, Cox, Michael, O’Brien, Jackie, Krause, Catherine, Nates, Joseph, Haque, Sajid, Mooring, Deidre, Erfe, Rose, Nickerson, Paula, Sherry, Tony, Smith, John, Sanderson, Barnaby, Ng, Josephine, Brooks, John, Lim, Ling, and Lei, Katie

Published
2017
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